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René Bindels

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Ramon Sonneveld; Johan Van der Vlag; Jack F M Wetzels; Jo H M Berden; René J M Bindels; Henry B P M Dijkman; Silvia Ferrè; Joost G J Hoenderop; Tom Nijenhuis
Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease.
Annelies A van Angelen; Annemiete W C M van der Kemp; Bob Glaudemans; Joost G J Hoenderop; René J M Bindels
Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice.
B C J van der Eerden; Ulrich Zügel; René J M Bindels; Nadja Fratzl-Zelman; Joost G J Hoenderop; Klaus Klaushofer; Tom Nijenhuis; Paul Roschger; Andreas Steinmeyer; Johannes P T M van Leeuwen
The vitamin D analog ZK191784 normalizes decreased bone matrix mineralization in mice lacking the calcium channel TRPV5.

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2013: Ramon Sonneveld; Johan Van der Vlag; Jack F M Wetzels; Jo H M Berden; René J M Bindels; Henry B P M Dijkman; Silvia Ferrè; Joost G J Hoenderop; Tom Nijenhuis
Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease.
The American journal of pathology 2013;182(4):1196-204.
2013: Annelies A van Angelen; Annemiete W C M van der Kemp; Bob Glaudemans; Joost G J Hoenderop; René J M Bindels
Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013;28(4):879-89.
2013: B C J van der Eerden; Ulrich Zügel; René J M Bindels; Nadja Fratzl-Zelman; Joost G J Hoenderop; Klaus Klaushofer; Tom Nijenhuis; Paul Roschger; Andreas Steinmeyer; Johannes P T M van Leeuwen
The vitamin D analog ZK191784 normalizes decreased bone matrix mineralization in mice lacking the calcium channel TRPV5.
Journal of cellular physiology 2013;228(2):402-7.
2013: Nellie Y Loh; Sian E Piret; Michael J Stechman; Paolo Tammaro; Sjoerd Verkaart; Bushra N Ahmad; Frances M Ashcroft; Ilaria Bellantuono; Liz Bentley; René J M Bindels; Steve D M Brown; Roger D Cox; Henrik Dimke; Holly Evans; William D Fraser; Caroline M Gorvin; Fadil M Hannan; Joost G J Hoenderop; Tertius A Hough; Rajesh V Thakker
Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5.
PloS one 2013;8(1):e55412.
2012: Silvia Ferrè; Joost G J Hoenderop; René J M Bindels
Sensing mechanisms involved in Ca2+ and Mg2+ homeostasis.
Kidney international 2012;82(11):1157-66.
2012: Kukiat Tudpor; Annemiete W C M van der Kemp; Siebe van Genesen; Sjoerd Verkaart; Nadezda V Kovalevskaya; Arjan J Kwakernaak; Sergio Laínez; gerjan navis; René J M Bindels; Joost G J Hoenderop
Urinary plasmin inhibits TRPV5 in nephrotic-range proteinuria.
Journal of the American Society of Nephrology : JASN 2012;23(11):1824-34.
2012: Titia E Woudenberg-Vrenken; René J M Bindels; B C J van der Eerden; Annemiete W C M van der Kemp; Johannes P T M van Leeuwen; Joost G J Hoenderop
Characterization of vitamin D-deficient klotho(-/-) mice: do increased levels of serum 1,25(OH)2D3 cause disturbed calcium and phosphate homeostasis in klotho(-/-) mice?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27(11):4061-8.
2012: Titia E Woudenberg-Vrenken; Anke L Lameris; Jenny Olausson; Petra Weissgerber; René J M Bindels; Veit Flockerzi; Marc Freichel; Joost G J Hoenderop
Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption.
American journal of physiology. Gastrointestinal and liver physiology 2012;303(7):G879-85.
2012: Nicolas Markadieu; Anil V Nair; Pedro San-Cristobal; Kukiat Tudpor; Femke van Zeeland; Sjoerd Verkaart; René J M Bindels; Ellen Lenssen; Johannes Loffing; Joost G J Hoenderop
A primary culture of distal convoluted tubules expressing functional thiazide-sensitive NaCl transport.
American journal of physiology. Renal physiology 2012;303(6):F886-92.
2012: B C J van der Eerden; Petra Weissgerber; René J M Bindels; H Chiba; Teun J de Vries; Marco Eijken; Veit Flockerzi; Nadja Fratzl-Zelman; Marc Freichel; Joost G J Hoenderop; Klaus Klaushofer; Jenny Olausson; Paul Roschger; Marijke Schreuders-Koedam; Johannes P T M van Leeuwen
The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice.
Journal of cellular physiology 2012;227(5):1951-9.
2012: Jeroen H F de Baaij; René J M Bindels; Kathrin Kopplin; Sergio Lainez; Iwan C Meij; Dominik Müller; Marchel Stuiver; Hanka Venselaar; Joost G J Hoenderop
Membrane topology and intracellular processing of cyclin M2 (CNNM2).
The Journal of biological chemistry 2012;287(17):13644-55.
2012: Olivier Devuyst; Francesco Emma; Ron Gansevoort; Patrick H Maxwell; Albert C M Ong; Giuseppe Remuzzi; Pierre Ronco; Corinne Antignac; René J M Bindels; Dominique Chauveau; Franz Schaefer
The ERA-EDTA Working Group on inherited kidney disorders.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27(1):67-9.
2011: Theun de Groot; Veronika A M te Boekhorst; Eline A E van der Hagen; Sjoerd Verkaart; René J M Bindels; Joost G J Hoenderop
Role of the transient receptor potential vanilloid 5 (TRPV5) protein N terminus in channel activity, tetramerization, and trafficking.
The Journal of biological chemistry 2011;286(37):32132-9.
2011: Silvia Ferrè; Joost J G Hoenderop; René J M Bindels
Role of the distal convoluted tubule in renal Mg2+ handling: molecular lessons from inherited hypomagnesemia.
Magnesium research : official organ of the International Society for the Development of Research on Magnesium 2011;24(3):S101-8.
2011: Kirsten Y Renkema; René J M Bindels; Joost G J Hoenderop
Role of the calcium-sensing receptor in reducing the risk for calcium stones.
Clinical journal of the American Society of Nephrology : CJASN 2011;6(8):2076-82.
2011: Theun de Groot; Marco Felici; René J M Bindels; Nadezda V Kovalevskaya; Nathalie Schilderink; Eline A E van der Hagen; Sjoerd Verkaart; Geerten W Vuister; Joost G J Hoenderop
Molecular mechanisms of calmodulin action on TRPV5 and modulation by parathyroid hormone.
Molecular and cellular biology 2011;31(14):2845-53.
2011: Henrik Dimke; Joost G J Hoenderop; René J M Bindels
Molecular basis of epithelial Ca2+ and Mg2+ transport: insights from the TRP channel family.
The Journal of physiology 2011;589(Pt 7):1535-42.
2011: Silvia Ferrè; Joost G J Hoenderop; René J M Bindels
Insight into renal Mg2+ transporters.
Current opinion in nephrology and hypertension 2011;20(2):169-76.
2011: Henrik Dimke; Pedro San-Cristobal; Mark de Graaf; Jacques W Lenders; jaap deinum; Joost G J Hoenderop; René J M Bindels
γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter.
Journal of the American Society of Nephrology : JASN 2011;22(3):508-17.
2011: Silvia Ferrè; Gert Jan C Veenstra; Rianne Bouwmeester; Joost G J Hoenderop; René J M Bindels
HNF-1B specifically regulates the transcription of the γa-subunit of the Na+/K+-ATPase.
Biochemical and biophysical research communications 2011;404(1):284-90.
2011: Titia E Woudenberg-Vrenken; Arjaree Sukinta; Annemiete W van der Kemp; René J M Bindels; Joost G J Hoenderop
Transient receptor potential melastatin 6 knockout mice are lethal whereas heterozygous deletion results in mild hypomagnesemia.
Nephron. Physiology 2011;117(2):p11-9.
2010: kyu pil lee; Anil V Nair; Christian Grimm; Femke van Zeeland; Stefan Heller; René J M Bindels; Joost G J Hoenderop
A helix-breaking mutation in the epithelial Ca(2+) channel TRPV5 leads to reduced Ca(2+)-dependent inactivation.
Cell calcium 2010;48(5):275-87.
2010: Anke L L Lameris; Sylvie Huybers; John R Burke; Leo A Monnens; René J M Bindels; Joost G J Hoenderop
Involvement of claudin 3 and claudin 4 in idiopathic infantile hypercalcaemia: a novel hypothesis?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010;25(11):3504-9.
2010: Theun de Groot; Sjoerd Verkaart; Qi Xi; René J M Bindels; Joost G J Hoenderop
The identification of Histidine 712 as a critical residue for constitutive TRPV5 internalization.
The Journal of biological chemistry 2010;285(37):28481-7.
2010: Pedro San-Cristobal; Henrik Dimke; Joost G J Hoenderop; René J M Bindels
Novel molecular pathways in renal Mg2+ transport: a guided tour along the nephron.
Current opinion in nephrology and hypertension 2010;19(5):456-62.
2010: Gang Cao; kyu pil lee; Jenny van der Wijst; Mark de Graaf; Annemiete W C M van der Kemp; René J M Bindels; Joost G J Hoenderop
Methionine sulfoxide reductase B1 (MsrB1) recovers TRPM6 channel activity during oxidative stress.
The Journal of biological chemistry 2010;285(34):26081-7.
2010: Henrik Dimke; Jenny van der Wijst; Todd R Alexander; Inez M J Meijer; Gemma M Mulder; Harry van Goor; Sabine Tejpar; Joost G J Hoenderop; René J M Bindels
Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling.
Journal of the American Society of Nephrology : JASN 2010;21(8):1309-16.
2010: René J M Bindels
2009 Homer W. Smith Award: Minerals in motion: from new ion transporters to new concepts.
Journal of the American Society of Nephrology : JASN 2010;21(8):1263-9.
2010: Yu-Juei Hsu; Henrik Dimke; Joost G J Hoenderop; René J M Bindels
Calcitonin-stimulated renal Ca2+ reabsorption occurs independently of TRPV5.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010;25(5):1428-35.
2010: Yu-Juei Hsu; Henrik Dimke; Joost P H Schoeber; Shih-Che Hsu; Shih-Hua Lin; Pauling Chu; Joost G J Hoenderop; René J M Bindels
Testosterone increases urinary calcium excretion and inhibits expression of renal calcium transport proteins.
Kidney international 2010;77(7):601-8.
2010: Jenny van der Wijst; Bob Glaudemans; Hanka Venselaar; Anil V Nair; Anna-Lena Forst; Joost G J Hoenderop; René J M Bindels
Functional analysis of the Kv1.1 N255D mutation associated with autosomal dominant hypomagnesemia.
The Journal of biological chemistry 2010;285(1):171-8.
2010: Bob Glaudemans; Nine V A M Knoers; Joost G J Hoenderop; René J M Bindels
New molecular players facilitating Mg(2+) reabsorption in the distal convoluted tubule.
Kidney international 2010;77(1):17-22.
2009: R Todd Alexander; Titia E Woudenberg-Vrenken; Jan Buurman; Henry Dijkman; B C J van der Eerden; Johannes P T M van Leeuwen; René J M Bindels; Joost G J Hoenderop
Klotho prevents renal calcium loss.
Journal of the American Society of Nephrology : JASN 2009;20(11):2371-9.
2009: Jenny van der Wijst; Joost G J Hoenderop; René J M Bindels
Epithelial Mg2+ channel TRPM6: insight into the molecular regulation.
Magnesium research : official organ of the International Society for the Development of Research on Magnesium 2009;22(3):127-32.
2009: Titia E Woudenberg-Vrenken; René J M Bindels; Joost G J Hoenderop
The role of transient receptor potential channels in kidney disease.
Nature reviews. Nephrology 2009;5(8):441-9.
2009: Kirsten Y Renkema; Ana Velic; Henry B P M Dijkman; Sjoerd Verkaart; Annemiete W C M van der Kemp; Marta Nowik; Kim Timmermans; Alain Doucet; Carsten A Wagner; René J M Bindels; Joost G J Hoenderop
The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis.
Journal of the American Society of Nephrology : JASN 2009;20(8):1705-13.
2009: Zhimin Miao; Yufang Gao; René J M Bindels; Wendong Yu; Yanhua Lang; Nan Chen; Hong Ren; Fang Sun; Yushan Li; Xianghua Wang; Leping Shao
Coexistence of normotensive primary aldosteronism in two patients with Gitelman's syndrome and novel thiazide-sensitive Na-Cl cotransporter mutations.
European journal of endocrinology / European Federation of Endocrine Societies 2009;161(2):275-83.
2009: Theun de Groot; Kyupil Lee; Michiel Langeslag; Qi Xi; Kees Jalink; René J M Bindels; Joost G J Hoenderop
Parathyroid hormone activates TRPV5 via PKA-dependent phosphorylation.
Journal of the American Society of Nephrology : JASN 2009;20(8):1693-704.
2009: René J M Bindels
A molecularly guided tour along the nephron.
Pflügers Archiv : European journal of physiology 2009;458(1):1-3.
2009: Sandor Boros; René J M Bindels; Joost G J Hoenderop
Active Ca(2+) reabsorption in the connecting tubule.
Pflügers Archiv : European journal of physiology 2009;458(1):99-109.
2009: Qi Xi; Joost G J Hoenderop; René J M Bindels
Regulation of magnesium reabsorption in DCT.
Pflügers Archiv : European journal of physiology 2009;458(1):89-98.
2009: Catalin N Topala; Joost P Schoeber; Lydia E Searchfield; Daniela Riccardi; Joost G J Hoenderop; René J M Bindels
Activation of the Ca2+-sensing receptor stimulates the activity of the epithelial Ca2+ channel TRPV5.
Cell calcium 2009;45(4):331-9.
2009: Joost P H Schoeber; Stan F J van de Graaf; kyu pil lee; Hanneke G M Wittgen; Joost G J Hoenderop; René J M Bindels
Conditional fast expression and function of multimeric TRPV5 channels using Shield-1.
American journal of physiology. Renal physiology 2009;296(1):F204-11.
2008: Theun de Groot; René J M Bindels; Joost G J Hoenderop
TRPV5: an ingeniously controlled calcium channel.
Kidney international 2008;74(10):1241-6.
2008: Joost P Schoeber; Catalin N Topala; kyu pil lee; Tim T Lambers; Guénola Ricard; Annemiete W C M van der Kemp; Martijn A Huynen; Joost G J Hoenderop; René J M Bindels
Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity.
Pflügers Archiv : European journal of physiology 2008;457(1):91-101.
2008: Stéphanie Thébault; Gang Cao; Hanka Venselaar; Qi Xi; René J M Bindels; Joost G J Hoenderop
Role of the alpha-kinase domain in transient receptor potential melastatin 6 channel and regulation by intracellular ATP.
The Journal of biological chemistry 2008;283(29):19999-20007.
2008: Gang Cao; Joost G J Hoenderop; René J M Bindels
Insight into the molecular regulation of the epithelial magnesium channel TRPM6.
Current opinion in nephrology and hypertension 2008;17(4):373-8.
2008: Sylvie Huybers; Maria Apostolaki; Bram C J van der Eerden; george kollias; Ton H J Naber; René J M Bindels; Joost G J Hoenderop
Murine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca2+ transporters.
Inflammatory bowel diseases 2008;14(6):803-11.
2008: Stan F J van de Graaf; Ursula Rescher; Joost G J Hoenderop; Sjoerd Verkaart; René J M Bindels; Volker Gerke
TRPV5 is internalized via clathrin-dependent endocytosis to enter a Ca2+-controlled recycling pathway.
The Journal of biological chemistry 2008;283(7):4077-86.
2008: Gang Cao; Stéphanie Thébault; Jenny van der Wijst; Annemiete W C M van der Kemp; Edwin Lasonder; René J M Bindels; Joost G J Hoenderop
RACK1 inhibits TRPM6 activity via phosphorylation of the fused alpha-kinase domain.
Current biology : CB 2008;18(3):168-76.
2008: Joost G J Hoenderop; René J M Bindels
Calciotropic and magnesiotropic TRP channels.
Physiology (Bethesda, Md.) 2008;23():32-40.
2008: Edinio R Cairo; Thomas Friedrich; Herman G P Swarts; Nine V Knoers; René J M Bindels; Leo A Monnens; Peter H G M Willems; Jan Joep H H M de Pont; Jan B Koenderink
Impaired routing of wild type FXYD2 after oligomerisation with FXYD2-G41R might explain the dominant nature of renal hypomagnesemia.
Biochimica et biophysica acta 2008;1778(2):398-404.
2007: Sylvie Huybers; René J M Bindels
Vascular calcification in chronic kidney disease: new developments in drug therapy.
Kidney international 2007;72(6):663-5.
2007: Wouter M Tiel Groenestege; Stéphanie Thébault; Jenny van der Wijst; Dennis van den Berg; Rob Janssen; Sabine Tejpar; Lambert P van den Heuvel; Eric Van Cutsem; Joost G J Hoenderop; Nine V A M Knoers; René J M Bindels
Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia.
The Journal of clinical investigation 2007;117(8):2260-7.
2007: Yu-Juei Hsu; Joost G J Hoenderop; René J M Bindels
TRP channels in kidney disease.
Biochimica et biophysica acta 2007;1772(8):928-36.
2007: Catalin N Topala; René J M Bindels; Joost G J Hoenderop
Regulation of the epithelial calcium channel TRPV5 by extracellular factors.
Current opinion in nephrology and hypertension 2007;16(4):319-24.
2007: Catalin N Topala; Wouter Tiel Groenestege; Stéphanie Thébault; Dennis van den Berg; Bernd Nilius; Joost G J Hoenderop; René J M Bindels
Molecular determinants of permeation through the cation channel TRPM6.
Cell calcium 2007;41(6):513-23.
2007: Joost P Schoeber; Joost G J Hoenderop; René J M Bindels
Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.
Biochemical Society transactions 2007;35(Pt 1):115-9.
2007: Tim T Lambers; Elena Oancea; Theun de Groot; Catalin N Topala; Joost G J Hoenderop; René J M Bindels
Extracellular pH dynamically controls cell surface delivery of functional TRPV5 channels.
Molecular and cellular biology 2007;27(4):1486-94.
2007: Stan F J van de Graaf; René J M Bindels; Joost G J Hoenderop
Physiology of epithelial Ca2+ and Mg2+ transport.
Reviews of physiology, biochemistry and pharmacology 2007;158():77-160.
2007: Arjen Mensenkamp; Joost G J Hoenderop; René J M Bindels
TRPV5, the gateway to Ca2+ homeostasis.
Handbook of experimental pharmacology 2007;(179):207-20.
2007: Sylvie Huybers; Ton H J Naber; René J M Bindels; Joost G J Hoenderop
Prednisolone-induced Ca2+ malabsorption is caused by diminished expression of the epithelial Ca2+ channel TRPV6.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(1):G92-7.
2006: Monique Van Abel; Sylvie Huybers; Joost G J Hoenderop; Annemiete W C M van der Kemp; Johannes P T M van Leeuwen; René J M Bindels
Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.
American journal of physiology. Renal physiology 2006;291(6):F1177-83.
2006: Dimitra Gkika; Yu-Juei Hsu; Annemiete W C M van der Kemp; Sylvia Christakos; René J M Bindels; Joost G J Hoenderop
Critical role of the epithelial Ca2+ channel TRPV5 in active Ca2+ reabsorption as revealed by TRPV5/calbindin-D28K knockout mice.
Journal of the American Society of Nephrology : JASN 2006;17(11):3020-7.
2006: Dimitra Gkika; Catalin N Topala; Qing Chang; Nicolas Picard; Stéphanie Thébault; Pascal Houillier; Joost G J Hoenderop; René J M Bindels
Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5.
The EMBO journal 2006;25(20):4707-16.
2006: Joost P Schoeber; Catalin N Topala; Xinhua Wang; Robin J W Diepens; Tim T Lambers; Joost G J Hoenderop; René J M Bindels
RGS2 inhibits the epithelial Ca2+ channel TRPV6.
The Journal of biological chemistry 2006;281(40):29669-74.
2006: Tom Nijenhuis; B C J van der Eerden; Ulrich Zügel; Andreas Steinmeyer; Harrie Weinans; Joost G J Hoenderop; Johannes P T M van Leeuwen; René J M Bindels
The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2171-3.
2006: Arjen Mensenkamp; Joost G J Hoenderop; René J M Bindels
Recent advances in renal tubular calcium reabsorption.
Current opinion in nephrology and hypertension 2006;15(5):524-9.
2006: Tim T Lambers; Frank Mahieu; Elena Oancea; Louis J C Hoofd; Frank de Lange; Arjen Mensenkamp; Thomas Voets; Bernd Nilius; David E Clapham; Joost G J Hoenderop; René J M Bindels
Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.
The EMBO journal 2006;25(13):2978-88.
2006: Math P Cuajungco; Christian Grimm; Kazuo Oshima; Dieter D'hoedt; Bernd Nilius; Arjen Mensenkamp; René J M Bindels; Markus Plomann; Stefan Heller
PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.
The Journal of biological chemistry 2006;281(27):18753-62.
2006: Stan F J van de Graaf; Joost G J Hoenderop; Annemiete W C M van der Kemp; Serge M Gisler; René J M Bindels
Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.
Pflügers Archiv : European journal of physiology 2006;452(4):407-17.
2006: Stan F J van de Graaf; Joost G J Hoenderop; René J M Bindels
Regulation of TRPV5 and TRPV6 by associated proteins.
American journal of physiology. Renal physiology 2006;290(6):F1295-302.
2006: Dimitra Gkika; Catalin N Topala; Joost G J Hoenderop; René J M Bindels
The immunophilin FKBP52 inhibits the activity of the epithelial Ca2+ channel TRPV5.
American journal of physiology. Renal physiology 2006;290(5):F1253-9.
2006: Stéphanie Thébault; Joost G J Hoenderop; René J M Bindels
Epithelial Ca2+ and Mg2+ channels in kidney disease.
Advances in chronic kidney disease 2006;13(2):110-7.
2006: Wouter M Tiel Groenestege; Joost G J Hoenderop; Lambert van Den Heuvel; Nine V A M Knoers; René J M Bindels
The epithelial Mg2+ channel transient receptor potential melastatin 6 is regulated by dietary Mg2+ content and estrogens.
Journal of the American Society of Nephrology : JASN 2006;17(4):1035-43.
2006: Tom Nijenhuis; Kirsten Y Renkema; Joost G J Hoenderop; René J M Bindels
Acid-base status determines the renal expression of Ca2+ and Mg2+ transport proteins.
Journal of the American Society of Nephrology : JASN 2006;17(3):617-26.
2006: Tim T Lambers; René J M Bindels; Joost G J Hoenderop
Coordinated control of renal Ca2+ handling.
Kidney international 2006;69(4):650-4.
2006: Stan F J van de Graaf; Annemiete W C M van der Kemp; Dennis van den Berg; Mijke van Oorschot; Joost G J Hoenderop; René J M Bindels
Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity.
Journal of the American Society of Nephrology : JASN 2006;17(1):26-30.
2006: Stan F J van de Graaf; Qing Chang; Arjen Mensenkamp; Joost G J Hoenderop; René J M Bindels
Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane.
Molecular and cellular biology 2006;26(1):303-12.
2005: Nicolas Picard; Monique Van Abel; Christelle Campone; Michelle Seiler; May Bloch-Faure; Joost G J Hoenderop; Johannes Loffing; Pierre Meneton; René J M Bindels; Michel Paillard; François Alhenc-Gelas; Pascal Houillier
Tissue kallikrein-deficient mice display a defect in renal tubular calcium absorption.
Journal of the American Society of Nephrology : JASN 2005;16(12):3602-10.
2005: B C J van der Eerden; Joost G J Hoenderop; Teun J de Vries; Ton Schoenmaker; Cok J Buurman; André G Uitterlinden; Huibert A P Pols; René J M Bindels; Johannes P T M van Leeuwen
The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(48):17507-12.
2005: Kirsten Y Renkema; Tom Nijenhuis; B C J van der Eerden; Annemiete W C M van der Kemp; Harrie Weinans; Johannes P T M van Leeuwen; René J M Bindels; Joost G J Hoenderop
Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice.
Journal of the American Society of Nephrology : JASN 2005;16(11):3188-95.
2005: Qing Chang; Susan Hoefs; Annemiete W C M van der Kemp; Catalin N Topala; René J M Bindels; Joost G J Hoenderop
The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.
Science (New York, N.Y.) 2005;310(5747):490-3.
2005: Monique Van Abel; Joost G J Hoenderop; Annemiete W C M van der Kemp; Michael M Friedlaender; Johannes P T M van Leeuwen; René J M Bindels
Coordinated control of renal Ca(2+) transport proteins by parathyroid hormone.
Kidney international 2005;68(4):1708-21.
2005: Tom Nijenhuis; Joost G J Hoenderop; René J M Bindels
TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate.
Pflügers Archiv : European journal of physiology 2005;451(1):181-92.
2005: Els den Dekker; Joost P Schoeber; Catalin N Topala; Stan F J van de Graaf; Joost G J Hoenderop; René J M Bindels
Characterization of a Madin-Darby canine kidney cell line stably expressing TRPV5.
Pflügers Archiv : European journal of physiology 2005;450(4):236-44.
2005: Elisabeth A M Cornelissen; René J M Bindels; Lies Hoefsloot; Nine V A M Knoers
[From gene to disease; mutations in the SLC12A3 gene as the cause of Gitelman's syndrome].
Nederlands tijdschrift voor geneeskunde 2005;149(24):1330-3.
2005: Tom Nijenhuis; Volker Vallon; Annemiete W C M van der Kemp; Johannes Loffing; Joost G J Hoenderop; René J M Bindels
Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia.
The Journal of clinical investigation 2005;115(6):1651-8.
2005: Joost Lensen; Angelique L W M M Rops; Tessa J M Wijnhoven; Theo Hafmans; W F J Feitz; Egbert Oosterwijk; Bernhard Banas; René J M Bindels; Lambert P van den Heuvel; Johan Van der Vlag; Jo H M Berden; Toin H van Kuppevelt
Localization and functional characterization of glycosaminoglycan domains in the normal human kidney as revealed by phage display-derived single chain antibodies.
Journal of the American Society of Nephrology : JASN 2005;16(5):1279-88.
2005: Joost G J Hoenderop; René J M Bindels
Is vitamin D indispensable for Ca2+ homeostasis: lessons from knockout mouse models?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005;20(5):864-7.
2005: Monique Van Abel; Joost G J Hoenderop; René J M Bindels
The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease.
Naunyn-Schmiedeberg's archives of pharmacology 2005;371(4):295-306.
2005: Monica Palmada; Susanne Poppendieck; Hamdy M Embark; Stan F J van de Graaf; Christoph Boehmer; René J M Bindels; Florian Lang
Requirement of PDZ domains for the stimulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase SGK1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2005;15(1-4):175-82.
2005: Joost G J Hoenderop; Bernd Nilius; René J M Bindels
Calcium absorption across epithelia.
Physiological reviews 2005;85(1):373-422.
2005: Joost G J Hoenderop; René J M Bindels
Epithelial Ca2+ and Mg2+ channels in health and disease.
Journal of the American Society of Nephrology : JASN 2005;16(1):15-26.
2004: Qing Chang; Emmanouela Gyftogianni; Stan F J van de Graaf; Susan Hoefs; Freek A Weidema; René J M Bindels; Joost G J Hoenderop
Molecular determinants in TRPV5 channel assembly.
The Journal of biological chemistry 2004;279(52):54304-11.
2004: Joost G J Hoenderop; Annemiete W C M van der Kemp; Colleen M Urben; Stephen A Strugnell; René J M Bindels
Effects of vitamin D compounds on renal and intestinal Ca2+ transport proteins in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice.
Kidney international 2004;66(3):1082-9.
2004: Tim T Lambers; A Freek Weidema; Bernd Nilius; Joost G J Hoenderop; René J M Bindels
Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin.
The Journal of biological chemistry 2004;279(28):28855-61.
2004: Dimitra Gkika; Frank Mahieu; Bernd Nilius; Joost G J Hoenderop; René J M Bindels
80K-H as a new Ca2+ sensor regulating the activity of the epithelial Ca2+ channel transient receptor potential cation channel V5 (TRPV5).
The Journal of biological chemistry 2004;279(25):26351-7.
2004: Stan F J van de Graaf; Inge Boullart; Joost G J Hoenderop; René J M Bindels
Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):303-8.
2004: Joke C De Jong; Peter H G M Willems; Monique Goossens; Alain Vandewalle; Lambert P van den Heuvel; Nine V A M Knoers; René J M Bindels
Effects of chemical chaperones on partially retarded NaCl cotransporter mutants associated with Gitelman's syndrome in a mouse cortical collecting duct cell line.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2004;19(5):1069-76.
2004: Tom Nijenhuis; Joost G J Hoenderop; René J M Bindels
Downregulation of Ca(2+) and Mg(2+) transport proteins in the kidney explains tacrolimus (FK506)-induced hypercalciuria and hypomagnesemia.
Journal of the American Society of Nephrology : JASN 2004;15(3):549-57.
2004: Robin J W Diepens; Els den Dekker; Marcelle Bens; A Freek Weidema; Alain Vandewalle; René J M Bindels; Joost G J Hoenderop
Characterization of a murine renal distal convoluted tubule cell line for the study of transcellular calcium transport.
American journal of physiology. Renal physiology 2004;286(3):F483-9.
2004: Joost G J Hoenderop; Helena Chon; Dimitra Gkika; Hans A R Bluyssen; Frank C P Holstege; René St-Arnaud; Branko Braam; René J M Bindels
Regulation of gene expression by dietary Ca2+ in kidneys of 25-hydroxyvitamin D3-1 alpha-hydroxylase knockout mice.
Kidney international 2004;65(2):531-9.
2004: Thomas Voets; Bernd Nilius; Susan Hoefs; Annemiete W C M van der Kemp; Guy Droogmans; René J M Bindels; Joost G J Hoenderop
TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption.
The Journal of biological chemistry 2004;279(1):19-25.
2004: Hamdy M Embark; Iwan Setiawan; Susanne Poppendieck; Stan F J van de Graaf; Christoph Boehmer; Monica Palmada; Thomas Wieder; Rüdiger Gerstberger; Philip Cohen; C Chris Yun; René J M Bindels; Florian Lang
Regulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3 expressed in Xenopus oocytes.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2004;14(4-6):203-12.
2003: Joost G J Hoenderop; Johannes P T M van Leeuwen; B C J van der Eerden; Ferry F J Kersten; Annemiete W C M van der Kemp; Anne-Marie Mérillat; Jan H Waarsing; Bernard C Rossier; Volker Vallon; Edith Hummler; René J M Bindels
Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5.
The Journal of clinical investigation 2003;112(12):1906-14.
2003: René J M Bindels
A molecular switch controlling renal sodium and potassium excretion.
Nature genetics 2003;35(4):302-3.
2003: Patrick Starremans; Ferry F J Kersten; Lambert P van den Heuvel; Nine V A M Knoers; René J M Bindels
Dimeric architecture of the human bumetanide-sensitive Na-K-Cl Co-transporter.
Journal of the American Society of Nephrology : JASN 2003;14(12):3039-46.
2003: Tom Nijenhuis; Joost G J Hoenderop; Annemiete W C M van der Kemp; René J M Bindels
Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney.
Journal of the American Society of Nephrology : JASN 2003;14(11):2731-40.
2003: Joke C De Jong; Peter H G M Willems; Lambert P van den Heuvel; Nine V A M Knoers; René J M Bindels
Functional expression of the human thiazide-sensitive NaCl cotransporter in Madin-Darby canine kidney cells.
Journal of the American Society of Nephrology : JASN 2003;14(10):2428-35.
2003: Tom Nijenhuis; Joost G J Hoenderop; Johannes Loffing; Annemiete W C M van der Kemp; Carel H van Os; René J M Bindels
Thiazide-induced hypocalciuria is accompanied by a decreased expression of Ca2+ transport proteins in kidney.
Kidney international 2003;64(2):555-64.
2003: Joke C De Jong; Peter H G M Willems; Fieke J M Mooren; Lambert P van den Heuvel; Nine V A M Knoers; René J M Bindels
The structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer.
The Journal of biological chemistry 2003;278(27):24302-7.
2003: Tom Nijenhuis; Joost G J Hoenderop; Bernd Nilius; René J M Bindels
(Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6.
Pflügers Archiv : European journal of physiology 2003;446(4):401-9.
2003: Monique Van Abel; Joost G J Hoenderop; Annemiete W C M van der Kemp; Johannes P T M van Leeuwen; René J M Bindels
Regulation of the epithelial Ca2+ channels in small intestine as studied by quantitative mRNA detection.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(1):G78-85.
2003: Patrick Starremans; Ferry F J Kersten; Nine V A M Knoers; Lambert P van den Heuvel; René J M Bindels
Mutations in the human Na-K-2Cl cotransporter (NKCC2) identified in Bartter syndrome type I consistently result in nonfunctional transporters.
Journal of the American Society of Nephrology : JASN 2003;14(6):1419-26.
2003: Joost G J Hoenderop; Bernd Nilius; René J M Bindels
Epithelial calcium channels: from identification to function and regulation.
Pflügers Archiv : European journal of physiology 2003;446(3):304-8.
2003: Els den Dekker; Joost G J Hoenderop; Bernd Nilius; René J M Bindels
The epithelial calcium channels, TRPV5 & TRPV6: from identification towards regulation.
Cell calcium 2003;33(5-6):497-507.
2003: Stan F J van de Graaf; Joost G J Hoenderop; Dimitra Gkika; Dennis Lamers; Jean Prenen; Ursula Rescher; Volker Gerke; Olivier Staub; Bernd Nilius; René J M Bindels
Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex.
The EMBO journal 2003;22(7):1478-87.
2003: Nine V A M Knoers; Joke C De Jong; Iwan C Meij; Lambert P van den Heuvel; René J M Bindels
Genetic renal disorders with hypomagnesemia and hypocalciuria.
Journal of nephrology 2003;16(2):293-6.
2003: Joost G J Hoenderop; Thomas Voets; Susan Hoefs; Freek A Weidema; Jean Prenen; Bernd Nilius; René J M Bindels
Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.
The EMBO journal 2003;22(4):776-85.
2003: Bernd Nilius; Freek A Weidema; Jean Prenen; Joost G J Hoenderop; Rudi Vennekens; Susan Hoefs; Guy Droogmans; René J M Bindels
The carboxyl terminus of the epithelial Ca(2+) channel ECaC1 is involved in Ca(2+)-dependent inactivation.
Pflügers Archiv : European journal of physiology 2003;445(5):584-8.
2002: Joost G J Hoenderop; Bernd Nilius; René J M Bindels
ECaC: the gatekeeper of transepithelial Ca2+ transport.
Biochimica et biophysica acta 2002;1600(1-2):6-11.
2002: Joost G J Hoenderop; Olivier Dardenne; Monique Van Abel; Annemiete W C M van der Kemp; Carel H van Os; René St Arnaud; René J M Bindels
Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(11):1398-406.
2002: Bernd Nilius; Jean Prenen; Joost G J Hoenderop; Rudi Vennekens; Susan Hoefs; A Freek Weidema; Guy Droogmans; René J M Bindels
Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.
The Journal of biological chemistry 2002;277(34):30852-8.
2002: Harriet S Tenenhouse; Claude Gauthier; Josée Martel; Joost G J Hoenderop; Anita Hartog; Martha H Meyer; Ralph A Meyer; René J M Bindels
Na/P(i) cotransporter ( Npt2) gene disruption increases duodenal calcium absorption and expression of epithelial calcium channels 1 and 2.
Pflügers Archiv : European journal of physiology 2002;444(5):670-6.
2002: Monique Van Abel; Joost G J Hoenderop; Olivier Dardenne; René St Arnaud; Carel H van Os; Hans J P T M Van Leeuwen; René J M Bindels
1,25-dihydroxyvitamin D(3)-independent stimulatory effect of estrogen on the expression of ECaC1 in the kidney.
Journal of the American Society of Nephrology : JASN 2002;13(8):2102-9.
2002: Lisette Dijkink; Anita Hartog; Carel H van Os; René J M Bindels
The epithelial sodium channel (ENaC) is intracellularly located as a tetramer.
Pflügers Archiv : European journal of physiology 2002;444(4):549-55.
2002: Rudi Vennekens; Thomas Voets; René J M Bindels; Guy Droogmans; Bernd Nilius
Current understanding of mammalian TRP homologues.
Cell calcium 2002;31(6):253-64.
2002: Joke C De Jong; Walter A Van Der Vliet; Lambert P van den Heuvel; Peter H G M Willems; Nine V A M Knoers; René J M Bindels
Functional expression of mutations in the human NaCl cotransporter: evidence for impaired routing mechanisms in Gitelman's syndrome.
Journal of the American Society of Nephrology : JASN 2002;13(6):1442-8.
2002: Susan W J Janssen; Joost G J Hoenderop; Ad R M M Hermus; Fred C G J Sweep; Gerard J M Martens; René J M Bindels
Expression of the novel epithelial Ca2+ channel ECaC1 in rat pancreatic islets.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002;50(6):789-98.
2002: Rémon A M H van Aubel; Pascal H E Smeets; Janny G P Peters; René J M Bindels; Frans G M Russel
The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP.
Journal of the American Society of Nephrology : JASN 2002;13(3):595-603.
2002: Joost G J Hoenderop; Bernd Nilius; René J M Bindels
Molecular mechanism of active Ca2+ reabsorption in the distal nephron.
Annual review of physiology 2002;64():529-49.
2002: Patrick Starremans; Annemiete W C M van der Kemp; Nine V A M Knoers; Lambert P van den Heuvel; René J M Bindels
Functional implications of mutations in the human renal outer medullary potassium channel (ROMK2) identified in Bartter syndrome.
Pflügers Archiv : European journal of physiology 2002;443(3):466-72.
2001: Thomas Voets; Jean Prenen; Andrea Fleig; Rudi Vennekens; Hiroyuki Watanabe; Joost G J Hoenderop; René J M Bindels; Guy Droogmans; Reinhold Penner; Bernd Nilius
CaT1 and the calcium release-activated calcium channel manifest distinct pore properties.
The Journal of biological chemistry 2001;276(51):47767-70.
2001: Joost G J Hoenderop; Rudi Vennekens; Dominik Müller; Jean Prenen; Guy Droogmans; René J M Bindels; Bernd Nilius
Function and expression of the epithelial Ca(2+) channel family: comparison of mammalian ECaC1 and 2.
The Journal of physiology 2001;537(Pt 3):747-61.
2001: Sophie van Cromphaut; Mieke Dewerchin; Joost G J Hoenderop; Ingrid Stockmans; Erik Van Herck; S Kato; René J M Bindels; Désiré Collen; Peter Carmeliet; Roger Bouillon; Geert Carmeliet
Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13324-9.
2001: Bernd Nilius; Jean Prenen; Rudi Vennekens; Joost G J Hoenderop; René J M Bindels; Guy Droogmans
Pharmacological modulation of monovalent cation currents through the epithelial Ca2+ channel ECaC1.
British journal of pharmacology 2001;134(3):453-62.
2001: Lisette Dijkink; Anita Hartog; Carel H van Os; René J M Bindels
Modulation of aldosterone-induced stimulation of ENaC synthesis by changing the rate of apical Na+ entry.
American journal of physiology. Renal physiology 2001;281(4):F687-92.
2001: Joost G J Hoenderop; Dominik Müller; Annemiete W C M van der Kemp; Anita Hartog; M Suzuki; K Ishibashi; M Imai; Fred C G J Sweep; Peter H G M Willems; Carel H van Os; René J M Bindels
Calcitriol controls the epithelial calcium channel in kidney.
Journal of the American Society of Nephrology : JASN 2001;12(7):1342-9.
2001: Bernd Nilius; Jean Prenen; Rudi Vennekens; Joost G J Hoenderop; René J M Bindels; Guy Droogmans
Modulation of the epithelial calcium channel, ECaC, by intracellular Ca2+.
Cell calcium 2001;29(6):417-28.
2001: Rudi Vennekens; Jean Prenen; Joost G J Hoenderop; René J M Bindels; Guy Droogmans; Bernd Nilius
Modulation of the epithelial Ca2+ channel ECaC by extracellular pH.
Pflügers Archiv : European journal of physiology 2001;442(2):237-42.
2001: Remko R Bosch; Joost G J Hoenderop; L van der Heijden; Jan Joep H H M de Pont; René J M Bindels; Peter H G M Willems
Hormonal regulation of phospholipase D activity in Ca(2+) transporting cells of rabbit connecting tubule and cortical collecting duct.
Biochimica et biophysica acta 2001;1538(2-3):329-38.
2001: Rudi Vennekens; Jean Prenen; Joost G J Hoenderop; René J M Bindels; Guy Droogmans; Bernd Nilius
Pore properties and ionic block of the rabbit epithelial calcium channel expressed in HEK 293 cells.
The Journal of physiology 2001;530(Pt 2):183-91.
2001: Bernd Nilius; Rudi Vennekens; Jean Prenen; Joost G J Hoenderop; Guy Droogmans; René J M Bindels
The single pore residue Asp542 determines Ca2+ permeation and Mg2+ block of the epithelial Ca2+ channel.
The Journal of biological chemistry 2001;276(2):1020-5.
2000: Iwan C Meij; Jan B Koenderink; Hans van Bokhoven; Karin Assink; W T Groenestege; Jan Joep H H M de Pont; René J M Bindels; Leo A H Monnens; Lambert P van den Heuvel; Nine V A M Knoers
Dominant isolated renal magnesium loss is caused by misrouting of the Na(+),K(+)-ATPase gamma-subunit.
Nature genetics 2000;26(3):265-6.
2000: Bernd Nilius; Rudi Vennekens; Jean Prenen; Joost G J Hoenderop; René J M Bindels; Guy Droogmans
Whole-cell and single channel monovalent cation currents through the novel rabbit epithelial Ca2+ channel ECaC.
The Journal of physiology 2000;527 Pt 2():239-48.
2000: Dominik Müller; Joost G J Hoenderop; Gerard F M Merkx; Carel H van Os; René J M Bindels
Gene structure and chromosomal mapping of human epithelial calcium channel.
Biochemical and biophysical research communications 2000;275(1):47-52.
2000: Rémon A M H van Aubel; Anita Hartog; René J M Bindels; Carel H van Os; Frans G M Russel
Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine.
European journal of pharmacology 2000;400(2-3):195-8.
2000: Dominik Müller; Joost G J Hoenderop; Iwan C Meij; Lambert P van den Heuvel; Nine V A M Knoers; Anneke I den Hollander; Paul Eggert; Víctor García-Nieto; Félix Claverie-Martín; René J M Bindels
Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1).
Genomics 2000;67(1):48-53.
2000: Joost G J Hoenderop; D Müller; M Suzuki; Carel H van Os; René J M Bindels
Epithelial calcium channel: gate-keeper of active calcium reabsorption.
Current opinion in nephrology and hypertension 2000;9(4):335-40.
2000: Joost G J Hoenderop; Anita Hartog; M Stuiver; A Doucet; Peter H G M Willems; René J M Bindels
Localization of the epithelial Ca(2+) channel in rabbit kidney and intestine.
Journal of the American Society of Nephrology : JASN 2000;11(7):1171-8.
2000: Joost G J Hoenderop; P H Willems; René J M Bindels
Toward a comprehensive molecular model of active calcium reabsorption.
American journal of physiology. Renal physiology 2000;278(3):F352-60.
2000: Rudi Vennekens; Joost G J Hoenderop; Jean Prenen; M Stuiver; P H Willems; Guy Droogmans; Bernd Nilius; René J M Bindels
Permeation and gating properties of the novel epithelial Ca(2+) channel.
The Journal of biological chemistry 2000;275(6):3963-9.
2000: I Matskevitch; C Stegen; Carsten A Wagner; I Moschén; René J M Bindels; C Van Os; Stefan Broer; Florian Lang
Acute regulation of the betaine/GABA transporter BGT-1 expressed in Xenopus oocytes by extracellular pH.
Kidney & blood pressure research 2000;23(6):356-9.
2000: René J M Bindels
Molecular pathophysiology of renal calcium handling.
Kidney & blood pressure research 2000;23(3-5):183-4.
1999: J van Baal; Joost G J Hoenderop; M Groenendijk; Carel H van Os; René J M Bindels; Peter H G M Willems
Hormone-stimulated Ca2+ transport in rabbit kidney: multiple sites of inhibition by exogenous ATP.
The American journal of physiology 1999;277(6 Pt 2):F899-906.
1999: Joost G J Hoenderop; Annemiete W C M van der Kemp; Anita Hartog; Carel H van Os; Peter H G M Willems; René J M Bindels
The epithelial calcium channel, ECaC, is activated by hyperpolarization and regulated by cytosolic calcium.
Biochemical and biophysical research communications 1999;261(2):488-92.
1999: Lisette Dijkink; Anita Hartog; Peter M T Deen; Carel H van Os; René J M Bindels
Time-dependent regulation by aldosterone of the amiloride-sensitive Na+ channel in rabbit kidney.
Pflügers Archiv : European journal of physiology 1999;438(3):354-60.
1999: Joost G J Hoenderop; Arie B Vaandrager; Lisette Dijkink; Albert Smolenski; Stepan Gambaryan; Suzanne M Lohmann; Hugo R de Jonge; Peter H G M Willems; René J M Bindels
Atrial natriuretic peptide-stimulated Ca2+ reabsorption in rabbit kidney requires membrane-targeted, cGMP-dependent protein kinase type II.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6084-9.
1999: Joost G J Hoenderop; Annemiete W C M van der Kemp; Anita Hartog; Stan F J van de Graaf; Carel H van Os; Peter H G M Willems; René J M Bindels
Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia.
The Journal of biological chemistry 1999;274(13):8375-8.
1999: Joost G J Hoenderop; Jan Joep H H M de Pont; René J M Bindels; Peter H G M Willems
Hormone-stimulated Ca2+ reabsorption in rabbit kidney cortical collecting system is cAMP-independent and involves a phorbol ester-insensitive PKC isotype.
Kidney international 1999;55(1):225-33.
1998: Joost G J Hoenderop; Anita Hartog; Peter H G M Willems; René J M Bindels
Adenosine-stimulated Ca2+ reabsorption is mediated by apical A1 receptors in rabbit cortical collecting system.
The American journal of physiology 1998;274(4 Pt 2):F736-43.
1998: SM Peters; U Rauen; MJ Tijsen; René J M Bindels; Carel H van Os; H de Groot; Jack F M Wetzels
Cold preservation of isolated rabbit proximal tubules induces radical-mediated cell injury.
Transplantation 1998;65(5):625-32.
1998: SM Peters; MJ Tijsen; Carel H van Os; Jack F M Wetzels; René J M Bindels
Hypoxia decreases calcium influx into rat proximal tubules.
Kidney international 1998;53(3):703-8.
1998: SM Peters; M D de Jong; René J M Bindels; Carel H van Os; Jack F M Wetzels
Effects of renal cytoprotective agents on erythrocyte membrane stability.
Life sciences 1998;63(11):975-83.
1997: MJ Tijsen; SM Peters; René J M Bindels; Carel H van Os; Jack F M Wetzels
Glycine protection against hypoxic injury in isolated rat proximal tubules: the role of proteases.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997;12(12):2549-56.
1997: G Raber; Peter H G M Willems; F Lang; Roland Nitschke; Carel H van Os; René J M Bindels
Co-ordinated control of apical calcium influx and basolateral calcium efflux in rabbit cortical collecting system.
Cell calcium 1997;22(3):157-66.
1997: SM Mulders; JP Rijss; Anita Hartog; René J M Bindels; Carel H van Os; Peter M T Deen
Importance of the mercury-sensitive cysteine on function and routing of AQP1 and AQP2 in oocytes.
The American journal of physiology 1997;273(3 Pt 2):F451-6.
1997: Peter M T Deen; Søren Nielsen; René J M Bindels; Carel H van Os
Apical and basolateral expression of aquaporin-1 in transfected MDCK and LLC-PK cells and functional evaluation of their transcellular osmotic water permeabilities.
Pflügers Archiv : European journal of physiology 1997;433(6):780-7.
1997: M A van Kuijck; Marcel Kool; Gerard F M Merkx; Ad Geurts van Kessel; René J M Bindels; Peter M T Deen; Carel H van Os
Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization.
Cytogenetics and cell genetics 1997;77(3-4):285-7.
1996: J van Baal; M D de Jong; Freek Jan Zijlstra; Peter H G M Willems; René J M Bindels
Endogenously produced prostanoids stimulate calcium reabsorption in the rabbit cortical collecting system.
The Journal of physiology 1996;497 ( Pt 1)():229-39.
1996: J van Baal; G Raber; J de Slegte; R Pieters; René J M Bindels; Peter H G M Willems
Vasopressin-stimulated Ca2+ reabsorption in rabbit cortical collecting system: effects on cAMP and cytosolic Ca2+.
Pflügers Archiv : European journal of physiology 1996;433(1-2):109-15.
1996: SM Peters; M J Tijsen; René J M Bindels; Carel H van Os; Jack F M Wetzels
Rise in cytosolic Ca2+ and collapse of mitochondrial potential in anoxic, but not hypoxic, rat proximal tubules.
Journal of the American Society of Nephrology : JASN 1996;7(11):2348-56.
1996: J Van Baal; A Yu; Anita Hartog; J A Fransen; Peter H G M Willems; Jonathan Lytton; René J M Bindels
Localization and regulation by vitamin D of calcium transport proteins in rabbit cortical collecting system.
The American journal of physiology 1996;271(5 Pt 2):F985-93.
1996: S L Abrahamse; R J Bridges; M D De Jong; René J M Bindels; Carel H van Os
Apical membrane isolation of surface and crypt cells from rabbit distal colon.
Analytical biochemistry 1996;242(1):112-22.
1996: René J M Bindels; A M Engbersen; Anita Hartog; B L Blazer-Yost
Aldosterone-induced proteins in primary cultures of rabbit renal cortical collecting system.
Biochimica et biophysica acta 1996;1284(1):63-8.
1996: N J Raat; Patrick De Smet; W van Driessche; René J M Bindels; Carel H van Os
Measuring volume perturbation of proximal tubular cells in primary culture with three different techniques.
The American journal of physiology 1996;271(1 Pt 1):C235-41.
1996: M A van Kuijck; Rémon A M H van Aubel; A E Busch; F Lang; Frans G M Russel; René J M Bindels; Carel H van Os; Peter M T Deen
Molecular cloning and expression of a cyclic AMP-activated chloride conductance regulator: a novel ATP-binding cassette transporter.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5401-6.
1996: Jonathan Lytton; S L Lee; W S Lee; J van Baal; René J M Bindels; Rachel Kilav; Tally Naveh-Many; J Silver
The kidney sodium-calcium exchanger.
Annals of the New York Academy of Sciences 1996;779():58-72.
1996: H P Koster; Anita Hartog; Carel H van Os; René J M Bindels
Inhibition of Na+ and Ca2+ reabsorption by P2u purinoceptors requires PKC but not Ca2+ signaling.
The American journal of physiology 1996;270(1 Pt 2):F53-60.
1996: N J Raat; E Delpire; Carel H van Os; René J M Bindels
Culturing induced expression of basolateral Na+-K+-2Cl- cotransporter BSC2 in proximal tubule, aortic endothelium, and vascular smooth muscle.
Pflügers Archiv : European journal of physiology 1996;431(3):458-60.
1995: SM Peters; M J Tijsen; René J M Bindels; Carel H van Os; Jack F M Wetzels
Protection against hypoxic injury of rat proximal tubules by felodipine via a calcium-independent mechanism.
Pflügers Archiv : European journal of physiology 1995;431(1):20-7.
1995: H P Koster; Anita Hartog; Carel H van Os; René J M Bindels
Calbindin-D28K facilitates cytosolic calcium diffusion without interfering with calcium signaling.
Cell calcium 1995;18(3):187-96.
1995: N J Raat; Carel H van Os; René J M Bindels
Effects of osmotic perturbation on [Ca2+]i and pHi in rabbit proximal tubular cells in primary culture.
The American journal of physiology 1995;269(2 Pt 2):F205-11.
1995: J A Timmermans; René J M Bindels; Carel H van Os
Stimulation of plasma membrane Ca2+ pump by calbindin-D28k and calmodulin is additive in EGTA-free solutions.
The Journal of nutrition 1995;125(7 Suppl):1981S-1986S.
1995: U M Rose; S L Abrahamse; J W Jansen; René J M Bindels; Carel H van Os
Cellular acidification occurs during anoxia in cultured, but not in freshly isolated, rabbit proximal tubular cells.
Pflügers Archiv : European journal of physiology 1995;429(5):722-8.
1995: S I Abrahamse; Hugo R de Jonge; René J M Bindels; Carel H van Os
Two distinct K(+)-ATPase activities in rabbit distal colon.
Biochemical and biophysical research communications 1995;207(3):1003-8.
1994: AA Benders; J Li; Robert A C Lock; René J M Bindels; S E Bonga; J H Veerkamp
Copper toxicity in cultured human skeletal muscle cells: the involvement of Na+/K(+)-ATPase and the Na+/Ca(2+)-exchanger.
Pflügers Archiv : European journal of physiology 1994;428(5-6):461-7.
1994: U M Rose; P Couwenberg; J W Jansen; René J M Bindels; Carel H van Os
Effects of substrate-free anoxia and veratridine on intracellular calcium concentration in isolated rat ventricular cardiomyocytes.
Pflügers Archiv : European journal of physiology 1994;428(2):142-9.
1994: S L Abrahamse; A Vis; René J M Bindels; Carel H van Os
Regulation of intracellular pH in crypt cells from rabbit distal colon.
The American journal of physiology 1994;267(3 Pt 1):G409-15.
1994: AA Benders; J H Veerkamp; Arie Oosterhof; P J Jongen; René J M Bindels; L M Smit; H F Busch; Ron A Wevers
Ca2+ homeostasis in Brody's disease. A study in skeletal muscle and cultured muscle cells and the effects of dantrolene an verapamil.
The Journal of clinical investigation 1994;94(2):741-8.
1994: U M Rose; Anita Hartog; J W Jansen; Carel H van Os; René J M Bindels
Anoxia-induced increases in intracellular calcium concentration in primary cultures of rabbit thick ascending limb of Henle's loop.
Biochimica et biophysica acta 1994;1226(3):291-9.
1994: N J Raat; Anita Hartog; Carel H van Os; René J M Bindels
Regulation of Na(+)-K(+)-2Cl- cotransport activity in rabbit proximal tubule primary culture.
The American journal of physiology 1994;267(1 Pt 2):F63-9.
1994: U M Rose; René J M Bindels; J W Jansen; Carel H van Os
Effects of Ca2+ channel blockers, low Ca2+ medium and glycine on cell Ca2+ and injury in anoxic rabbit proximal tubules.
Kidney international 1994;46(1):223-9.
1994: Rosalinde Masereeuw; E J van den Bergh; René J M Bindels; Frans G M Russel
Characterization of fluorescein transport in isolated proximal tubular cells of the rat: evidence for mitochondrial accumulation.
The Journal of pharmacology and experimental therapeutics 1994;269(3):1261-7.
1994: René J M Bindels; Anita Hartog; S L Abrahamse; Carel H van Os
Effects of pH on apical calcium entry and active calcium transport in rabbit cortical collecting system.
The American journal of physiology 1994;266(4 Pt 2):F620-7.
1993: U M Rose; René J M Bindels; A Vis; J W Jansen; Carel H van Os
The effect of L-type Ca2+ channel blockers on anoxia-induced increases in intracellular Ca2+ concentration in rabbit proximal tubule cells in primary culture.
Pflügers Archiv : European journal of physiology 1993;423(5-6):378-86.
1993: H P Koster; Carel H van Os; René J M Bindels
Ca2+ oscillations in the rabbit renal cortical collecting system induced by Na+ free solutions.
Kidney international 1993;43(4):828-36.
1993: René J M Bindels; J A Dempster; P L Ramakers; Peter H G M Willems; Carel H van Os
Effect of protein kinase C activation and down-regulation on active calcium transport.
Kidney international 1993;43(2):295-300.
1992: S L Abrahamse; René J M Bindels; Carel H van Os
The colon carcinoma cell line Caco-2 contains an H+/K(+)-ATPase that contributes to intracellular pH regulation.
Pflügers Archiv : European journal of physiology 1992;421(6):591-7.
1992: René J M Bindels; P L Ramakers; J A Dempster; Anita Hartog; Carel H van Os
Role of Na+/Ca2+ exchange in transcellular Ca2+ transport across primary cultures of rabbit kidney collecting system.
Pflügers Archiv : European journal of physiology 1992;420(5-6):566-72.
1991: René J M Bindels; J A Timmermans; Anita Hartog; wilko coers; Carel H van Os
Calbindin-D9k and parvalbumin are exclusively located along basolateral membranes in rat distal nephron.
Journal of the American Society of Nephrology : JASN 1991;2(6):1122-9.
1991: René J M Bindels; Anita Hartog; J Timmermans; Carel H van Os
Active Ca2+ transport in primary cultures of rabbit kidney CCD: stimulation by 1,25-dihydroxyvitamin D3 and PTH.
The American journal of physiology 1991;261(5 Pt 2):F799-807.
1991: J A Timmermans; R Kaune; René J M Bindels; Carel H van Os
Quantification of Ca(2+)-ATPases in porcine duodenum. Effects of 1,25(OH)2D3 deficiency.
Biochimica et biophysica acta 1991;1065(2):177-84.
1991: René J M Bindels; Anita Hartog; J A Timmermans; Carel H van Os
Immunocytochemical localization of calbindin-D28k, calbindin-D9k and parvalbumin in rat kidney.
Contributions to nephrology 1991;91():7-13.
1988: René J M Bindels; Lambertus van den Broek; Carel H van Os
Phosphate and calcium homeostasis in young spontaneously hypertensive rats.
Progress in clinical and biological research 1988;252():93-8.
1988: René J M Bindels; Lambertus van den Broek; Carel H van Os
Effect of pH on the low and high affinity Na+-phosphate co-transport system in rat renal cortex.
Progress in clinical and biological research 1988;252():359-64.
1987: R J Bindels; René J M Bindels; M J Jongen; W H Hackeng; C W Löwik; Lambertus van den Broek
Increased plasma calcitonin levels in young spontaneously hypertensive rats: role in disturbed phosphate homeostasis.
Pflügers Archiv : European journal of physiology 1987;408(4):395-400.
1987: René J M Bindels; L A van den Broek; Lambertus van den Broek
Effect of pH on the kinetics of Na+-dependent phosphate transport in rat renal brush-border membranes.
Biochimica et biophysica acta 1987;897(1):83-92.