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Nelson Ruiz-Opazo

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Victoria L M Herrera; Khristine A Pasion; Glaiza A Tan; Nelson Ruiz-Opazo
Dahl (S × R) rat congenic strain analysis confirms and defines a chromosome 17 spatial navigation quantitative trait locus to <10 Mbp.
Victoria L M Herrera; Ann Marie Moran; Khristine A Pasion; Nelson Ruiz-Opazo
Worse renal disease in postmenopausal F2[Dahl S x R]-intercross rats: detection of novel QTLs affecting hypertensive kidney disease.
Julius L Decano; Nicholas Giordano; Ann Marie Moran; Nelson Ruiz-Opazo; Victoria L M Herrera
Analysis of CD45- [CD34+/KDR+] endothelial progenitor cells as juvenile protective factors in a rat model of ischemic-hemorrhagic stroke.

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All Publications

2013: Victoria L M Herrera; Khristine A Pasion; Glaiza A Tan; Nelson Ruiz-Opazo
Dahl (S × R) rat congenic strain analysis confirms and defines a chromosome 17 spatial navigation quantitative trait locus to <10 Mbp.
PloS one 2013;8(2):e58280.
2013: Victoria L M Herrera; Ann Marie Moran; Khristine A Pasion; Nelson Ruiz-Opazo
Worse renal disease in postmenopausal F2[Dahl S x R]-intercross rats: detection of novel QTLs affecting hypertensive kidney disease.
PloS one 2013;8(2):e56096.
2013: Julius L Decano; Nicholas Giordano; Ann Marie Moran; Nelson Ruiz-Opazo; Victoria L M Herrera
Analysis of CD45- [CD34+/KDR+] endothelial progenitor cells as juvenile protective factors in a rat model of ischemic-hemorrhagic stroke.
PloS one 2013;8(1):e55222.
2012: Victoria L M Herrera; Yuichi Matsubara; Lorenz R B Ponce; Nelson Ruiz-Opazo
Distinct QTLs cosegregate with worse hypertension and renal disease in ovariectomized F2[Dahl S × R]-intercross rats.
Journal of hypertension 2012;30(8):1572-80.
2012: Victoria L M Herrera; Ann Marie Moran; Khristine A Pasion; Nelson Ruiz-Opazo
Differential genetic basis for pre-menopausal and post-menopausal salt-sensitive hypertension.
PloS one 2012;7(8):e43160.
2012: Victoria L M Herrera; Ann Marie Moran; Khristine A Pasion; Nelson Ruiz-Opazo
Dahl (S x R) congenic strain analysis confirms and defines a chromosome 5 female-specific blood pressure quantitative trait locus to <7 Mbp.
PloS one 2012;7(7):e42214.
2011: Julius L Decano; Anne Marie Moran; Nelson Ruiz-Opazo; Victoria L M Herrera
Molecular imaging of vasa vasorum neovascularization via DEspR-targeted contrast-enhanced ultrasound micro-imaging in transgenic atherosclerosis rat model.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2011;13(6):1096-106.
2011: Nicola Glorioso; Victoria L M Herrera; Chiara Troffa; Giuseppe Argiolas; Emanuela Bulla; Patrizia Bulla; Tamara Didishvili; Nelson Ruiz-Opazo
DEspR T/CATAAAA-box promoter variant decreases DEspR transcription and is associated with increased BP in Sardinian males.
Physiological genomics 2011;43(21):1219-25.
2011: Victoria L M Herrera; Pia Bagamasbad; Julius L Decano; Nelson Ruiz-Opazo
AVR/NAVR deficiency lowers blood pressure and differentially affects urinary concentrating ability, cognition, and anxiety-like behavior in male and female mice.
Physiological genomics 2011;43(1):32-42.
2009: Julius L Decano; Jason C Viereck; Ann C McKee; James A Hamilton; Nelson Ruiz-Opazo; Victoria L M Herrera
Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein.
Circulation 2009;119(11):1501-9.
2009: Victoria L M Herrera; Julius L Decano; Martin Steffen; Nelson Ruiz-Opazo
Autophagy: insights from DEspR-deficiency and haploinsufficiency.
Autophagy 2009;5(2):259-62.
2008: Victoria L M Herrera; Julius L Decano; Pia Bagamasbad; Timothy Kufahl; Martin Steffen; Nelson Ruiz-Opazo
Sex-specific hippocampus-dependent cognitive deficits and increased neuronal autophagy in DEspR haploinsufficiency in mice.
Physiological genomics 2008;35(3):316-29.
2008: Victoria L M Herrera; Pia Bagamasbad; Tamara Didishvili; Julius L Decano; Nelson Ruiz-Opazo
Overlapping genes in Nalp6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR.
Physiological genomics 2008;34(1):65-77.
2007: Victoria L M Herrera; Lorenz R B Ponce; Nelson Ruiz-Opazo
Genome-wide scan for interacting loci affecting human cholesteryl ester transfer protein-induced hypercholesterolemia in transgenic human cholesteryl ester transfer protein F2-intercross rats.
Journal of hypertension 2007;25(8):1608-12.
2007: Nicola Glorioso; Victoria L M Herrera; Pia Bagamasbad; Fabiana Filigheddu; Chiara Troffa; Giuseppe Argiolas; Emanuela Bulla; Julius L Decano; Nelson Ruiz-Opazo
Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects.
Circulation research 2007;100(10):1522-9.
2007: Kumar U. Kotlo; Douglas E Hughes; Victoria L M Herrera; Nelson Ruiz-Opazo; Robert H Costa; R Brooks Robey; Robert S Danziger
Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat.
Hypertension 2007;49(3):467-72.
2006: Victoria L M Herrera; Aristides Tsikoudakis; Lorenz R B Ponce; Yuichi Matsubara; Nelson Ruiz-Opazo
Sex-specific QTLs and interacting loci underlie salt-sensitive hypertension and target organ complications in Dahl S/jrHS hypertensive rats.
Physiological genomics 2006;26(3):172-9.
2006: Nelson Ruiz-Opazo; John Tonkiss
Genome-wide scan for quantitative trait loci influencing spatial navigation and social recognition memory in Dahl rats.
Physiological genomics 2006;26(2):145-51.
2005: Victoria L M Herrera; Lorenz R B Ponce; Pia Bagamasbad; Benjamin D VanPelt; Tamara Didishvili; Nelson Ruiz-Opazo
Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis.
Physiological genomics 2005;23(3):257-68.
2005: Yuji Kaneko; Jean-Francois Cloix; Victoria L M Herrera; Nelson Ruiz-Opazo
Corroboration of Dahl S Q276L alpha1Na,K-ATPase protein sequence: impact on affinities for ligands and on E1 conformation.
Journal of hypertension 2005;23(4):745-52.
2005: Victoria L M Herrera; Nelson Ruiz-Opazo
Genetic studies in rat models: insights into cardiovascular disease.
Current opinion in lipidology 2005;16(2):179-91.
2005: Yuji Kaneko; Victoria L M Herrera; Tamara Didishvili; Nelson Ruiz-Opazo
Sex-specific effects of dual ET-1/ANG II receptor (Dear) variants in Dahl salt-sensitive/resistant hypertension rat model.
Physiological genomics 2005;20(2):157-64.
2004: Victoria L M Herrera; Aristides Tsikoudakis; Tamara Didishvili; Lorenz R B Ponce; Pia Bagamasbad; Donald L Gantz; Haya Herscovitz; Arie Van Tol; Nelson Ruiz-Opazo
Analysis of gender-specific atherosclerosis susceptibility in transgenic[hCETP]25DS rat model.
Atherosclerosis 2004;177(1):9-18.
2004: Nelson Ruiz-Opazo; Lyle V Lopez; John Tonkiss
Modulation of learning and memory in Dahl rats by dietary salt restriction.
Hypertension 2004;43(4):797-802.
2004: Victoria L M Herrera; Tamara Didishvili; Lyle V Lopez; Richard H Myers; Nelson Ruiz-Opazo
Genome-wide scan identifies novel QTLs for cholesterol and LDL levels in F2[Dahl RxS]-intercross rats.
Circulation research 2004;94(4):446-52.
2004: Nelson Ruiz-Opazo; John Tonkiss
X-linked loci influence spatial navigation performance in Dahl rats.
Physiological genomics 2004;16(3):329-33.
2004: Nelson Ruiz-Opazo; Kenneth S Kosik; Lyle V Lopez; Pia Bagamasbad; Lorenz R B Ponce; Victoria L M Herrera
Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats.
Molecular medicine (Cambridge, Mass.) 2004;10(1-6):36-44.
2003: Victoria L M Herrera; Li Shen; Lyle V Lopez; Tamara Didishvili; You-Xun Zhang; Nelson Ruiz-Opazo
Chlamydia pneumoniae accelerates coronary artery disease progression in transgenic hyperlipidemia-genetic hypertension rat model.
Molecular medicine (Cambridge, Mass.) 2003;9(5-8):135-42.
2003: Victoria L M Herrera; Sarah Traverse; Lyle V Lopez; Nelson Ruiz-Opazo
X-linked locus associated with hypertensive renal disease susceptibility in Dahl rats.
Journal of hypertension 2003;21(1):67-71.
2002: Victoria M L Herrera; Tamara Didishvili; Lyle V Lopez; Nelson Ruiz-Opazo
Differential regulation of functional gene clusters in overt coronary artery disease in a transgenic atherosclerosis-hypertensive rat model.
Molecular medicine (Cambridge, Mass.) 2002;8(7):367-75.
2002: Nelson Ruiz-Opazo; Lyle V Lopez; Victoria L M Herrera
The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model.
Molecular medicine (Cambridge, Mass.) 2002;8(1):24-32.
2001: V M Herrera; Tamara Didishvili; Lyle V Lopez; Kimberly Zander; S Traverse; Donald L Gantz; Haya Herscovitz; Nelson Ruiz-Opazo
Hypertension exacerbates coronary artery disease in transgenic hyperlipidemic Dahl salt-sensitive hypertensive rats.
Molecular medicine (Cambridge, Mass.) 2001;7(12):831-44.
2001: Y Song; Victoria L M Herrera; Fabiana Filigheddu; Chiara Troffa; Lyle V Lopez; Nicola Glorioso; Nelson Ruiz-Opazo
Non-association of the thiazide-sensitive Na,Cl-cotransporter gene with polygenic hypertension in both rats and humans.
Journal of hypertension 2001;19(9):1547-51.
2001: Nicola Glorioso; Fabiana Filigheddu; Chiara Troffa; Aldo Soro; Paolo Pinna Parpaglia; Aristides Tsikoudakis; Richard H Myers; Victoria L M Herrera; Nelson Ruiz-Opazo
Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension.
Hypertension 2001;38(2):204-9.
2001: Victoria L M Herrera; Nelson Ruiz-Opazo
Identification of a novel V1-type AVP receptor based on the molecular recognition theory.
Molecular medicine (Cambridge, Mass.) 2001;7(7):499-506.
2001: Victoria L M Herrera; Lyle V Lopez; Nelson Ruiz-Opazo
Alpha1 Na,K-ATPase and Na,K,2Cl-cotransporte/D3mit3 loci interact to increase susceptibility to salt-sensitive hypertension in Dahl S(HSD) rats.
Molecular medicine (Cambridge, Mass.) 2001;7(2):125-34.
1999: Victoria L M Herrera; S C Makrides; Hou-Xiang Xie; H Adari; R M Krauss; Una S Ryan; Nelson Ruiz-Opazo
Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein.
Nature medicine 1999;5(12):1383-9.
1998: Victoria L M Herrera; Hou-Xiang Xie; Lyle V Lopez; N J Schork; Nelson Ruiz-Opazo
The alpha1 Na,K-ATPase gene is a susceptibility hypertension gene in the Dahl salt-sensitiveHSD rat.
The Journal of clinical investigation 1998;102(6):1102-11.
1998: John Tonkiss; M Trzcińska; Janina R Galler; Nelson Ruiz-Opazo; Victoria L M Herrera
Prenatal malnutrition-induced changes in blood pressure: dissociation of stress and nonstress responses using radiotelemetry.
Hypertension 1998;32(1):108-14.
1998: Nelson Ruiz-Opazo; K Hirayama; K Akimoto; Victoria L M Herrera
Molecular characterization of a dual endothelin-1/Angiotensin II receptor.
Molecular medicine (Cambridge, Mass.) 1998;4(2):96-108.
1998: Nelson Ruiz-Opazo
Identification of a novel dual angiotensin II/vasopressin receptor.
Néphrologie 1998;19(7):417-20.
1997: Nelson Ruiz-Opazo; J F Cloix; M G Melis; XH Xiang; Victoria L M Herrera
Characterization of a sodium-response transcriptional mechanism.
Hypertension 1997;30(2 Pt 1):191-8.
1997: C B Gonzalez; Victoria L M Herrera; Nelson Ruiz-Opazo
Renal immunocytochemical distribution and pharmacological properties of the dual angiotensin II/AVP receptor.
Hypertension 1997;29(4):957-61.
1997: Nelson Ruiz-Opazo; XH Xiang; Victoria L M Herrera
Pressure-overload deinduction of human alpha 2 Na,K-ATPase gene expression in transgenic rats.
Hypertension 1997;29(2):606-12.
1995: Nelson Ruiz-Opazo; K Akimoto; Victoria L M Herrera
Identification of a novel dual angiotensin II/vasopressin receptor on the basis of molecular recognition theory.
Nature medicine 1995;1(10):1074-81.
1994: Nelson Ruiz-Opazo; F Barany; K Hirayama; Victoria L M Herrera
Confirmation of mutant alpha 1 Na,K-ATPase gene and transcript in Dahl salt-sensitive/JR rats.
Hypertension 1994;24(3):260-70.
1994: Victoria L M Herrera; Nelson Ruiz-Opazo
Beyond genetic markers: hypertension genes.
Journal of hypertension 1994;12(8):847-56.
1994: Victoria L M Herrera; T Cova; D Sassoon; Nelson Ruiz-Opazo
Developmental cell-specific regulation of Na(+)-K(+)-ATPase alpha 1-, alpha 2-, and alpha 3-isoform gene expression.
The American journal of physiology 1994;266(5 Pt 1):C1301-12.
1994: Nelson Ruiz-Opazo; J F Cloix; Victoria L M Herrera
Differential interaction of the dual alpha tropomyosin/N5 enhancer with multiple DNA binding proteins: N5 is a putative novel z-ZIP DNA binding protein.
Cellular & molecular biology research 1994;40(4):265-72.
1994: Victoria L M Herrera; Nelson Ruiz-Opazo
Genetic analysis of hypertension in animal models and human hypertensive patients.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1994;12(7):S47-55.
1993: M Canessa; Jose R Romero; Nelson Ruiz-Opazo; Victoria L M Herrera
The alpha 1 Na(+)-K+ pump of the Dahl salt-sensitive rat exhibits altered Na+ modulation of K+ transport in red blood cells.
The Journal of membrane biology 1993;134(2):107-22.
1992: Nelson Ruiz-Opazo; Victoria L M Herrera
Analysis of Na+ pump genes.
Hypertension 1992;19(5):495-6.
1990: Victoria L M Herrera; Nelson Ruiz-Opazo
Alteration of alpha 1 Na+,K(+)-ATPase 86Rb+ influx by a single amino acid substitution.
Science (New York, N.Y.) 1990;249(4972):1023-6.
1990: Victoria L M Herrera; Nelson Ruiz-Opazo
Regulation of alpha-tropomyosin and N5 genes by a shared enhancer. Modular structure and hierarchical organization.
The Journal of biological chemistry 1990;265(16):9555-62.
1988: Victoria L M Herrera; Aram V Chobanian; Nelson Ruiz-Opazo
Isoform-specific modulation of Na+, K+-ATPase alpha-subunit gene expression in hypertension.
Science (New York, N.Y.) 1988;241(4862):221-3.
1988: S C Makrides; Nelson Ruiz-Opazo; M Hayden; A L Nussbaum; J L Breslow; Vassilis I Zannis
Sequence and expression of Tangier apoA-I gene.
European journal of biochemistry / FEBS 1988;173(2):465-71.
1988: Nelson Ruiz-Opazo; Vassilis I Zannis
Expression of the human apolipoprotein A-I gene in rat myogenic L6E9 cells. DNA methylation and regulation of gene activity.
The Journal of biological chemistry 1988;263(4):1739-44.
1987: K P Claffey; Victoria L M Herrera; Peter Brecher; Nelson Ruiz-Opazo
Cloning and tissue distribution of rat heart fatty acid binding protein mRNA: identical forms in heart and skeletal muscle.
Biochemistry 1987;26(24):7900-4.
1987: Victoria L M Herrera; J R Emanuel; Nelson Ruiz-Opazo; R Levenson; B Nadal-Ginard
Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.
The Journal of cell biology 1987;105(4):1855-65.