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Jürgen Ruland

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Katrin Schweneker; Marc Schweneker; Jürg Tschopp; Oliver Gorka; Christian Peschel; Hendrik Poeck; Jürgen Ruland; Olaf Gross
The mycobacterial cord factor adjuvant analogue trehalose-6,6'-dibehenate (TDB) activates the Nlrp3 inflammasome.
Gloria Lutzny; Robert Oostendorp; Christian Peschel; Jan Dürig; Alexander Egle; Andrew J Finch; Claudia Haferlach; Ludger Klein-Hitpass; Thomas Kocher; Alexander Kohlmann; Toni Kuhnt; Benedikt Lampl; Michael Leitges; Martina Rudelius; Jürgen Ruland; Yvonne Schäfer; Marc Schmidt-Supprian; Susanne Schnittger; Marc Seifert; Michaela Wagner; Stefan Wanninger; Nadja Zaborsky; Ingo Ringshausen
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.
Sabrina Marion; Julie Mazzolini; Jürgen Ruland; Martin Sachse; Margot Thome; Alexandre Benmerah; Pierre Bourdoncle; Arnaud Echard; Stephan Hailfinger; Floriane Herit; Nadège Kambou-Pene; Florence Niedergang
The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles.

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All Publications

2013: Katrin Schweneker; Marc Schweneker; Jürg Tschopp; Oliver Gorka; Christian Peschel; Hendrik Poeck; Jürgen Ruland; Olaf Gross
The mycobacterial cord factor adjuvant analogue trehalose-6,6'-dibehenate (TDB) activates the Nlrp3 inflammasome.
Immunobiology 2013;218(4):664-73.
2013: Gloria Lutzny; Robert Oostendorp; Christian Peschel; Jan Dürig; Alexander Egle; Andrew J Finch; Claudia Haferlach; Ludger Klein-Hitpass; Thomas Kocher; Alexander Kohlmann; Toni Kuhnt; Benedikt Lampl; Michael Leitges; Martina Rudelius; Jürgen Ruland; Yvonne Schäfer; Marc Schmidt-Supprian; Susanne Schnittger; Marc Seifert; Michaela Wagner; Stefan Wanninger; Nadja Zaborsky; Ingo Ringshausen
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.
Cancer cell 2013;23(1):77-92.
2012: Sabrina Marion; Julie Mazzolini; Jürgen Ruland; Martin Sachse; Margot Thome; Alexandre Benmerah; Pierre Bourdoncle; Arnaud Echard; Stephan Hailfinger; Floriane Herit; Nadège Kambou-Pene; Florence Niedergang
The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles.
Developmental cell 2012;23(5):954-67.
2012: Zeinab Abdullah; Winfried Barchet; Jan Böttcher; Trinad Chakraborty; Filiz Civril; Jörg H Fritz; Sergej Geiger; Torsten Hain; Gunther Hartmann; Yoshihiro Hayakawa; Karl-Peter Hopfner; Christian Kurts; Mobarak Abu Mraheil; Susanne Roth; Jürgen Ruland; Martin Schlee; Percy A Knolle
RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids.
The EMBO journal 2012;31(21):4153-64.
2012: Dominikus Strasser; Henning Urlaub; Gottfried Baier; Hanna Bergmann; Frank Brombacher; Gordon D Brown; Reto Guler; Karl-Peter Hopfner; Michael Leitges; Mohlopheni J Marakalala; Konstantin Neumann; Anna Rojowska; Jürgen Ruland
Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity.
Immunity 2012;36(1):32-42.
2012: Susanne Kratzat; Cornelius Miething; Viktoriya Nikolova; Jonas Nilsson; Christian Peschel; Elke Pietschmann; Jürgen Ruland; Stephanie Schoeffmann; Justus Duyster; Oliver Gorka; Alexander Hoellein; Anna-Lena Illert; Ulrich Keller
Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies.
PloS one 2012;7(5):e37433.
2012: Hendrik Poeck; Jürgen Ruland
From virus to inflammation: mechanisms of RIG-I-induced IL-1β production.
European journal of cell biology 2012;91(1):59-64.
2011: Susanne Roth; Jürgen Ruland
Caspase-8: clipping off RIG-I signaling.
Immunity 2011;34(3):283-5.
2010: Manuel Ritter; Olaf Gross; Sarah Kays; Jürgen Ruland; Falk Nimmerjahn; Shinobu Saijo; Jürg Tschopp; Laura E Layland; Clarissa Prazeres da Costa
Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(47):20459-64.
2010: Hendrik Poeck; Jürgen Ruland
SYK kinase signaling and the NLRP3 inflammasome in antifungal immunity.
Journal of molecular medicine (Berlin, Germany) 2010;88(8):745-52.
2010: Hendrik Poeck; Jürgen Ruland
ITAM receptor signaling and the NLRP3 inflammasome in antifungal immunity.
Journal of clinical immunology 2010;30(4):496-501.
2010: Konstanze Pechloff; Julian Holch; Uta Ferch; Marc Schweneker; Kristina Brunner; Markus Kremer; Tim D. Sparwasser; Leticia Quintanilla-Martinez; Ursula Zimber-Strobl; Berthold Streubel; Andreas Gewies; Christian Peschel; Jürgen Ruland
The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.
The Journal of experimental medicine 2010;207(5):1031-44.
2010: Hanne Schoenen; Barbara Bodendorfer; Kelly Jane Hitchens; Silvia Manzanero; Kerstin Werninghaus; Falk Nimmerjahn; Else Marie Agger; Steffen Stenger; Peter Andersen; Jürgen Ruland; Gordon D Brown; Christine Wells; Roland Lang
Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(6):2756-60.
2010: Hendrik Poeck; Michael Bscheider; Olaf Gross; Katrin Finger; Susanne Roth; Manuele Rebsamen; Nicole Hannesschläger; Martin Schlee; Simon Rothenfusser; Winfried Barchet; Hiroki Kato; Shizuo Akira; Satoshi Inoue; Stefan Endres; Christian Peschel; Gunther Hartmann; Veit Hornung; Jürgen Ruland
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.
Nature immunology 2010;11(1):63-9.
2009: Erik-Oliver Glocker; Andre Hennigs; Mohammad Nabavi; Alejandro A Schäffer; Cristina Woellner; Ulrich Salzer; Dietmar Pfeifer; Hendrik Veelken; Klaus Warnatz; Fariba Tahami; Sarah Jamal; Annabelle Manguiat; Nima Rezaei; Ali Akbar Amirzargar; Alessandro Plebani; Nicole Hannesschläger; Olaf Gross; Jürgen Ruland; Bodo Grimbacher
A homozygous CARD9 mutation in a family with susceptibility to fungal infections.
The New England journal of medicine 2009;361(18):1727-35.
2009: Uta Ferch; Bernhard Kloo; Andreas Gewies; Vera Pfänder; Michael Düwel; Christian Peschel; Daniel Krappmann; Jürgen Ruland
Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells.
The Journal of experimental medicine 2009;206(11):2313-20.
2009: Matthew J Robinson; Fabiola Osorio; Marcela Rosas; Rui P Freitas; Edina Schweighoffer; Olaf Gross; Sjef Verbeek; Jürgen Ruland; Victor L J Tybulewicz; Gordon D Brown; Luis Ferreira Moita; Philip R Taylor; Caetano Reis e Sousa
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.
The Journal of experimental medicine 2009;206(9):2037-51.
2009: Olaf Gross; Hendrik Poeck; Michael Bscheider; Catherine Dostert; Nicole Hannesschläger; Stefan Endres; Gunther Hartmann; Aubry Tardivel; Edina Schweighoffer; Victor L J Tybulewicz; Attila Mócsai; Jürg Tschopp; Jürgen Ruland
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
Nature 2009;459(7245):433-6.
2009: Christian Steinberg; Katharina Eisenächer; Olaf Gross; Wolfgang Reindl; Frank Schmitz; Jürgen Ruland; Anne Krug
The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection.
European journal of immunology 2009;39(4):1007-18.
2009: Kerstin Werninghaus; Anna Babiak; Olaf Gross; Christoph Hölscher; Harald Dietrich; Else Marie Agger; Jörg Mages; Attila Mócsai; Hanne Schoenen; Katrin Finger; Falk Nimmerjahn; Gordon D Brown; Carsten J Kirschning; Antje Heit; Peter Andersen; Hermann Wagner; Jürgen Ruland; Roland Lang
Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation.
The Journal of experimental medicine 2009;206(1):89-97.
2008: Olaf Gross; Christina Grupp; Christian Steinberg; Stephanie Zimmermann; Dominikus Strasser; Nicole Hannesschläger; Wolfgang Reindl; Helena Jonsson; Hairong Huo; Dan R Littman; Christian Peschel; Wayne M Yokoyama; Anne Krug; Jürgen Ruland
Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production.
Blood 2008;112(6):2421-8.
2008: Martin Schaefer; Norbert Reiling; Cornelia Fessler; Johannes Stephani; Ichiro Taniuchi; Farahnaz Hatam; Ali Oender Yildirim; Heinz Fehrenbach; Kerstin Walter; Jürgen Ruland; Hermann Wagner; Stefan Ehlers; Tim D. Sparwasser
Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6836-45.
2007: Andrea Oeckinghaus; Elmar Wegener; Verena Welteke; Uta Ferch; Seda Cöl Arslan; Jürgen Ruland; Claus Scheidereit; Daniel Krappmann
Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation.
The EMBO journal 2007;26(22):4634-45.
2007: Uta Ferch; Christian Meyer zum Büschenfelde; Andreas Gewies; Elmar Wegener; Sandra Rauser; Christian Peschel; Daniel Krappmann; Jürgen Ruland
MALT1 directs B cell receptor-induced canonical nuclear factor-kappaB signaling selectively to the c-Rel subunit.
Nature immunology 2007;8(9):984-91.
2007: Ravi S Misra; Jennifer Q Russell; Andreas Koenig; Jennifer A Hinshaw-Makepeace; Renren Wen; Demin Wang; Hairong Huo; Dan R Littman; Uta Ferch; Jürgen Ruland; Margot Thome; Ralph C Budd
Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.
The Journal of biological chemistry 2007;282(27):19365-74.
2007: Salomé LeibundGut-Landmann; Olaf Gross; Matthew J Robinson; Fabiola Osorio; Emma C Slack; S Vicky Tsoni; Edina Schweighoffer; Victor L J Tybulewicz; Gordon D Brown; Jürgen Ruland; Caetano Reis e Sousa
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.
Nature immunology 2007;8(6):630-8.
2007: Daniel Rueda; Olivier Gaide; Liza Ho; Elodie Lewkowicz; Florence Niedergang; Stephan Hailfinger; Fabien Rebeaud; Montserrat Guzzardi; Béatrice Conne; Marcus Thelen; Jérôme Delon; Uta Ferch; Tak W Mak; Jürgen Ruland; Juerg Schwaller; Margot Thome
Bcl10 controls TCR- and FcgammaR-induced actin polymerization.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4373-84.
2007: Philipp J Jost; Jürgen Ruland
Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications.
Blood 2007;109(7):2700-7.
2007: Philipp J Jost; Stephanie Weiss; Uta Ferch; Olaf Gross; Tak W Mak; Christian Peschel; Jürgen Ruland
Bcl10/Malt1 signaling is essential for TCR-induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):953-60.
2007: Stefanie Klemm; Stephanie Zimmermann; Christian Peschel; Tak W Mak; Jürgen Ruland
Bcl10 and Malt1 control lysophosphatidic acid-induced NF-kappaB activation and cytokine production.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):134-8.
2006: Philipp J Jost; Christian Peschel; Jürgen Ruland
The Bcl10/Malt1 signaling pathway as a drug target in lymphoma.
Current drug targets 2006;7(10):1335-40.
2006: Olaf Gross; Andreas Gewies; Katrin Finger; Martin Schäfer; Tim D. Sparwasser; Christian Peschel; Irmgard Förster; Jürgen Ruland
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.
Nature 2006;442(7103):651-6.
2006: Elmar Wegener; Andrea Oeckinghaus; Nikoletta Papadopoulou; Liron Lavitas; Marc Schmidt-Supprian; Uta Ferch; Tak W Mak; Jürgen Ruland; Vigo Heissmeyer; Daniel Krappmann
Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.
Molecular cell 2006;23(1):13-23.
2006: Stefanie Klemm; Jan Gutermuth; Lothar Hültner; Tim D. Sparwasser; Heidrun Behrendt; Christian Peschel; Tak W Mak; Thilo Jakob; Jürgen Ruland
The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation.
The Journal of experimental medicine 2006;203(2):337-47.
2006: Stefanie Klemm; Jürgen Ruland
Inflammatory signal transduction from the Fc epsilon RI to NF-kappa B.
Immunobiology 2006;211(10):815-20.