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Erkki Ruoslahti

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Scott Jenning; Tri Pham; Erkki Ruoslahti; Shubha Kale Ireland; Hector Biliran
Bit1 in anoikis resistance and tumor metastasis.
Renwei Chen; Xiuquan Luo; Kazuki N Sugahara; Tambet Teesalu; Gary B Braun; Erkki Ruoslahti
Application of a proapoptotic peptide to intratumorally spreading cancer therapy.
Luca Alberici; Claudio Bordignon; Venkata R Kotamraju; Gian-Paolo Rizzardi; Lise Roth; Kazuki N Sugahara; Tambet Teesalu; Catia Traversari; Lilach Agemy; Erkki Ruoslahti
De novo design of a tumor-penetrating peptide.

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All Publications

2013: Scott Jenning; Tri Pham; Erkki Ruoslahti; Shubha Kale Ireland; Hector Biliran
Bit1 in anoikis resistance and tumor metastasis.
Cancer letters 2013;333(2):147-51.
2013: Renwei Chen; Xiuquan Luo; Kazuki N Sugahara; Tambet Teesalu; Gary B Braun; Erkki Ruoslahti
Application of a proapoptotic peptide to intratumorally spreading cancer therapy.
Cancer research 2013;73(4):1352-61.
2013: Luca Alberici; Claudio Bordignon; Venkata R Kotamraju; Gian-Paolo Rizzardi; Lise Roth; Kazuki N Sugahara; Tambet Teesalu; Catia Traversari; Lilach Agemy; Erkki Ruoslahti
De novo design of a tumor-penetrating peptide.
Cancer research 2013;73(2):804-12.
2013: Abraham Rothman; Erkki Ruoslahti; Valeri Sarukhanov; Robert G Wiencek; Roy Williams; Stephanie Davidson; William N Evans; Humberto Restrepo; David Mann
Vascular histomolecular analysis by sequential endoarterial biopsy in a shunt model of pulmonary hypertension.
Pulmonary circulation 2013;3(1):50-7.
2013: David Zanuy; Lilach Agemy; Gema Ballano; Carlos Cativiela; Ana I Jiménez; Venkata Ramana Kotamraju; Ruth Nussinov; Guillem Revilla-López; Erkki Ruoslahti; April M Sawvel; Francisco J Sayago; Galen Stucky; Carlos Alemán
Engineering strategy to improve peptide analogs: from structure-based computational design to tumor homing.
Journal of computer-aided molecular design 2013;27(1):31-43.
2012: Chris Brunquell; Renwei Chen; Shubha Kale Ireland; Scott Jennings; Hector Biliran; Erkki Ruoslahti
TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells.
Molecular cancer research : MCR 2012;10(11):1482-95.
2012: Yin Ren; David E Root; Erkki Ruoslahti; Pablo Tamayo; Geoffrey von Maltzhan; Barbara A Weir; Amit Agrawal; Jesse S Boehm; Hiu Wing Cheung; Glenn S Cowley; Ronny Drapkin; Valentina Fogal; William C Hahn; Michelle S Hirsch; Alison M Karst; Joyce F Liu; Justin Lo; Jill P Mesirov; Sangeeta N Bhatia
Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4.
Science translational medicine 2012;4(147):147ra112.
2012: Junko Sawada; Akane Urakami; Takeo Urakami; Weiquan Zhu; Minoru Fukuda; Dean Y Li; Fangfei Li; Erkki Ruoslahti; Masanobu Komatsu
Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels.
Cancer cell 2012;22(2):235-49.
2012: Oran Erster; Jennifer A Getz; Sejal S Hall; Juliana Hamzah; Abeer M Jabaiah; Erkki Ruoslahti; Tobias D Schoep; Jerry M Thomas; Patrick S Daugherty
Site-specific targeting of antibody activity in vivo mediated by disease-associated proteases.
Journal of controlled release : official journal of the Controlled Release Society 2012;161(3):804-12.
2012: Erkki Ruoslahti
Peptides as targeting elements and tissue penetration devices for nanoparticles.
Advanced materials (Deerfield Beach, Fla.) 2012;24(28):3747-56.
2012: Priya Prakash Karmali; Ji-Ho Park; Erkki Ruoslahti; Michael J Sailor; Ying Chao; Sadik C Esener; Dmitri Simberg
Different effect of hydrogelation on antifouling and circulation properties of dextran-iron oxide nanoparticles.
Molecular pharmaceutics 2012;9(3):539-45.
2011: Lilach Agemy; Dinorah Friedmann-Morvinski; Olivier M Girard; Venkata Ramana Kotamraju; Robert F Mattrey; Lise Roth; Kazuki N Sugahara; Inder M Verma; Erkki Ruoslahti
Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(42):17450-5.
2011: Joseph M Kinsella; Erkki Ruoslahti; Miriam Scadeng; Shalini Ananda; Jennifer S Andrew; Miao-Ping Chien; Nathan C Gianneschi; Joel F Grondek; Michael J Sailor
Enhanced magnetic resonance contrast of Fe₃O₄ nanoparticles trapped in a porous silicon nanoparticle host.
Advanced materials (Deerfield Beach, Fla.) 2011;23(36):H248-53.
2011: Ying-Hua Yang; Rajesh Rajaiah; Erkki Ruoslahti; Kamal D Moudgil
Peptides targeting inflamed synovial vasculature attenuate autoimmune arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(31):12857-62.
2011: Geoffrey von Maltzahn; Wolfgang E Berdel; Kevin Y Lin; Rolf Mesters; Ji-Ho Park; Erkki Ruoslahti; Michael J Sailor; Christian Schwöppe; Neetu Singh; Sangeeta N Bhatia
Nanoparticles that communicate in vivo to amplify tumour targeting.
Nature materials 2011;10(7):545-52.
2011: Takeo Urakami; Tero A H Järvinen; Michie Toba; Junko Sawada; Namasivayam Ambalavanan; David Mann; Ivan McMurtry; Masahiko Oka; Erkki Ruoslahti; Masanobu Komatsu
Peptide-directed highly selective targeting of pulmonary arterial hypertension.
The American journal of pathology 2011;178(6):2489-95.
2011: O M Girard; Jiang Du; L Agemy; K N Sugahara; V R Kotamraju; Erkki Ruoslahti; Graeme M Bydder; Robert F Mattrey
Optimization of iron oxide nanoparticle detection using ultrashort echo time pulse sequences: comparison of T1, T2*, and synergistic T1- T2* contrast mechanisms.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2011;65(6):1649-60.
2011: Jean-Luc Fraikin; Tambet Teesalu; Christopher M McKenney; Erkki Ruoslahti; Andrew N Cleland
A high-throughput label-free nanoparticle analyser.
Nature nanotechnology 2011;6(5):308-13.
2011: Jinpeng Wang; Yanli Liu; Tambet Teesalu; Kazuki N Sugahara; Venkata Ramana Kotamrajua; Jonathan D Adams; Brian S Ferguson; Qiang Gong; Seung Soo Oh; Andrew T Csordas; Minseon Cho; Erkki Ruoslahti; Yi Xiao; Hyongsok T Soh
Selection of phage-displayed peptides on live adherent cells in microfluidic channels.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):6909-14.
2011: Juliana Hamzah; Venkata R Kotamraju; Jai W Seo; Lilach Agemy; Valentina Fogal; Lisa M Mahakian; David Peters; Lise Roth; M Karen J Gagnon; Katherine W Ferrara; Erkki Ruoslahti
Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):7154-9.
2011: Nurit Haspel; David Zanuy; Ruth Nussinov; Tambet Teesalu; Erkki Ruoslahti; Carlos Aleman
Binding of a C-end rule peptide to the neuropilin-1 receptor: a molecular modeling approach.
Biochemistry 2011;50(10):1755-62.
2011: David Sánchez-Martín; Angel M Cuesta; Valentina Fogal; Erkki Ruoslahti; Luis Alvarez-Vallina
The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies.
The Journal of biological chemistry 2011;286(7):5197-203.
2011: Priya Prakash Karmali; Erkki Ruoslahti; Hau Tram; Chris Brunquell; Shubha Kale Ireland; Hector Biliran
Metastasis of tumor cells is enhanced by downregulation of Bit1.
PloS one 2011;6(8):e23840.
2010: Tero A H Järvinen; Erkki Ruoslahti
Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in mice.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21671-6.
2010: Luo Gu; Ji-Ho Park; Kim H Duong; Erkki Ruoslahti; Michael J Sailor
Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads.
Small (Weinheim an der Bergstrasse, Germany) 2010;6(22):2546-52.
2010: Lilach Agemy; Kazuki N Sugahara; Venkata Ramana Kotamraju; Kunal Gujraty; Olivier M Girard; Yuko Kono; Robert F Mattrey; Ji-Ho Park; Michael J Sailor; Ana I Jimenez; Carlos Cativiela; David Zanuy; Francisco J Sayago; Carlos Aleman; Ruth Nussinov; Erkki Ruoslahti
Nanoparticle-induced vascular blockade in human prostate cancer.
Blood 2010;116(15):2847-56.
2010: Gunjan Malik; Lynn M Knowles; Rajiv Dhir; Shuping Xu; Shuting Yang; Erkki Ruoslahti; Jan Pilch
Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion.
Cancer research 2010;70(11):4327-34.
2010: Kazuki N Sugahara; Tambet Teesalu; Priya Prakash Karmali; Venkata Ramana Kotamraju; Lilach Agemy; Daniel R Greenwald; Erkki Ruoslahti
Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs.
Science (New York, N.Y.) 2010;328(5981):1031-5.
2010: Poornima Kolhar; Venkata Ramana Kotamraju; Sherry T Hikita; Dennis O Clegg; Erkki Ruoslahti
Synthetic surfaces for human embryonic stem cell culture.
Journal of biotechnology 2010;146(3):143-6.
2010: Erkki Ruoslahti; Sangeeta N Bhatia; Michael J Sailor
Targeting of drugs and nanoparticles to tumors.
The Journal of cell biology 2010;188(6):759-68.
2010: Valentina Fogal; Adam Richardson; Priya P Karmali; Immo E Scheffler; Jeffrey W Smith; Erkki Ruoslahti
Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation.
Molecular and cellular biology 2010;30(6):1303-18.
2010: Ji-Ho Park; Geoffrey von Maltzahn; Luvena L Ong; Andrea Centrone; T Alan Hatton; Erkki Ruoslahti; Sangeeta N Bhatia; Michael J Sailor
Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery.
Advanced materials (Deerfield Beach, Fla.) 2010;22(8):880-5.
2010: Ji-Ho Park; Geoffrey von Maltzahn; Mary Jue Xu; Valentina Fogal; Venkata Ramana Kotamraju; Erkki Ruoslahti; Sangeeta N Bhatia; Michael J Sailor
Cooperative nanomaterial system to sensitize, target, and treat tumors.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(3):981-6.
2009: Dmitri Simberg; Wan-Ming Zhang; Sergei Merkulov; Keith McCrae; Ji-Ho Park; Michael J Sailor; Erkki Ruoslahti
Contact activation of kallikrein-kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivo.
Journal of controlled release : official journal of the Controlled Release Society 2009;140(3):301-5.
2009: Kazuki N Sugahara; Tambet Teesalu; Priya Prakash Karmali; Venkata Ramana Kotamraju; Lilach Agemy; Olivier M Girard; Douglas Hanahan; Robert F Mattrey; Erkki Ruoslahti
Tissue-penetrating delivery of compounds and nanoparticles into tumors.
Cancer cell 2009;16(6):510-20.
2009: Tambet Teesalu; Kazuki N Sugahara; Venkata Ramana Kotamraju; Erkki Ruoslahti
C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16157-62.
2009: Yu Zhang; Mo Yang; Ji-Ho Park; Jennifer Singelyn; Huiqing Ma; Michael J Sailor; Erkki Ruoslahti; Mihrimah Ozkan; Cengiz S Ozkan
A surface-charge study on cellular-uptake behavior of F3-peptide-conjugated iron oxide nanoparticles.
Small (Weinheim an der Bergstrasse, Germany) 2009;5(17):1990-6.
2009: Dmitri Simberg; Ji-Ho Park; Priya P Karmali; Wan-Ming Zhang; Sergei Merkulov; Keith McCrae; Sangeeta N Bhatia; Michael Sailor; Erkki Ruoslahti
Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance.
Biomaterials 2009;30(23-24):3926-33.
2009: Mark Kastantin; Badriprasad Ananthanarayanan; Priya Karmali; Erkki Ruoslahti; Matthew Tirrell
Effect of the lipid chain melting transition on the stability of DSPE-PEG(2000) micelles.
Langmuir : the ACS journal of surfaces and colloids 2009;25(13):7279-86.
2009: David Peters; Mark Kastantin; Venkata Ramana Kotamraju; Priya Prakash Karmali; Kunal Gujraty; Matthew Tirrell; Erkki Ruoslahti
Targeting atherosclerosis by using modular, multifunctional micelles.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9815-9.
2009: David Zanuy; Alejandra Flores-Ortega; Ana I Jiménez; M Isabel Calaza; Carlos Cativiela; Ruth Nussinov; Erkki Ruoslahti; Carlos Alemán
In silico molecular engineering for a targeted replacement in a tumor-homing peptide.
The journal of physical chemistry. B 2009;113(22):7879-89.
2009: Ji-Ho Park; Luo Gu; Geoffrey von Maltzahn; Erkki Ruoslahti; Sangeeta N Bhatia; Michael J Sailor
Biodegradable luminescent porous silicon nanoparticles for in vivo applications.
Nature materials 2009;8(4):331-6.
2009: Ji-Ho Park; Geoffrey von Maltzahn; Lianglin Zhang; Austin M Derfus; Dmitri Simberg; Todd J Harris; Erkki Ruoslahti; Sangeeta N Bhatia; Michael J Sailor
Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting.
Small (Weinheim an der Bergstrasse, Germany) 2009;5(6):694-700.
2009: Priya Prakash Karmali; Venkata Ramana Kotamraju; Mark Kastantin; Matthew Black; Dimitris Missirlis; Matthew Tirrell; Erkki Ruoslahti
Targeting of albumin-embedded paclitaxel nanoparticles to tumors.
Nanomedicine : nanotechnology, biology, and medicine 2009;5(1):73-82.
2009: Valentina Fogal; Kazuki N Sugahara; Erkki Ruoslahti; Sven Christian
Cell surface nucleolin antagonist causes endothelial cell apoptosis and normalization of tumor vasculature.
Angiogenesis 2009;12(1):91-100.
2008: Hector Biliran; Yiwen Jan; Renwei Chen; Elena B Pasquale; Erkki Ruoslahti
Protein kinase D is a positive regulator of Bit1 apoptotic function.
The Journal of biological chemistry 2008;283(42):28029-37.
2008: Valentina Fogal; Lianglin Zhang; Stan Krajewski; Erkki Ruoslahti
Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma.
Cancer research 2008;68(17):7210-8.
2008: Geoffrey von Maltzahn; Yin Ren; Ji-Ho Park; Dal-Hee Min; Venkata Ramana Kotamraju; Jayanthi Jayakumar; Valentina Fogal; Michael J Sailor; Erkki Ruoslahti; Sangeeta N Bhatia
In vivo tumor cell targeting with "click" nanoparticles.
Bioconjugate chemistry 2008;19(8):1570-8.
2008: Hua Zhang; Jiro Kusunose; Azadeh Kheirolomoom; Jai W Seo; Jinyi Qi; Katherine D Watson; Heather A Lindfors; Erkki Ruoslahti; Julie L Sutcliffe; Katherine W Ferrara
Dynamic imaging of arginine-rich heart-targeted vehicles in a mouse model.
Biomaterials 2008;29(12):1976-88.
2008: Rania Kairouz-Wahbe; Hector Biliran; Xiuquan Luo; Ingwei Khor; Miriam Wankell; Cynthia Besch-Williford; Jaime Pascual; Robert Glen Oshima; Erkki Ruoslahti
Anoikis effector Bit1 negatively regulates Erk activity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1528-32.
2008: Ji-Ho Park; Geoffrey von Maltzahn; Erkki Ruoslahti; Sangeeta N Bhatia; Michael J Sailor
Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery.
Angewandte Chemie (International ed. in English) 2008;47(38):7284-8.
2008: Pirjo Laakkonen; Lianglin Zhang; Erkki Ruoslahti
Peptide targeting of tumor lymph vessels.
Annals of the New York Academy of Sciences 2008;1131():37-43.
2007: Austin M Derfus; Alice A Chen; Dal-Hee Min; Erkki Ruoslahti; Sangeeta N Bhatia
Targeted quantum dot conjugates for siRNA delivery.
Bioconjugate chemistry 2007;18(5):1391-6.
2007: Tero A H Järvinen; Erkki Ruoslahti
Molecular changes in the vasculature of injured tissues.
The American journal of pathology 2007;171(2):702-11.
2007: Kazuhiro Sugihara; Daijiro Sugiyama; James Byrne; Don P Wolf; Kevin P Lowitz; Yoichi Kobayashi; Maryam Kabir-Salmani; Daita Nadano; Daisuke Aoki; Shiro Nozawa; Jun Nakayama; Tomas Mustelin; Erkki Ruoslahti; Naoto Yamaguchi; Michiko N Fukuda
Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3799-804.
2007: Dmitri Simberg; Tasmia Duza; Ji Ho Park; Markus Essler; Jan Pilch; Lianglin Zhang; Austin M Derfus; Meng Yang; Robert M Hoffman; Sangeeta Bhatia; Michael J Sailor; Erkki Ruoslahti
Biomimetic amplification of nanoparticle homing to tumors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):932-6.
2007: Seung-Min Lee; Eun-Ju Lee; Hai-Yan Hong; Mi-Kyung Kwon; Tae-Hwan Kwon; Je-Yong Choi; Rang-Woon Park; Tae-Gyun Kwon; Eun-Sang Yoo; Gil-Suk Yoon; In-San Kim; Erkki Ruoslahti; Byung-Heon Lee
Targeting bladder tumor cells in vivo and in the urine with a peptide identified by phage display.
Molecular cancer research : MCR 2007;5(1):11-9.
2006: Anna R Mäkelä; Heli Matilainen; Daniel J White; Erkki Ruoslahti; Christian Oker-Blom
Enhanced baculovirus-mediated transduction of human cancer cells by tumor-homing peptides.
Journal of virology 2006;80(13):6603-11.
2006: Lianglin Zhang; Enrico Giraudo; Jason A Hoffman; Douglas Hanahan; Erkki Ruoslahti
Lymphatic zip codes in premalignant lesions and tumors.
Cancer research 2006;66(11):5696-706.
2006: Todd J Harris; Geoffrey von Maltzahn; Austin M Derfus; Erkki Ruoslahti; Sangeeta N Bhatia
Proteolytic actuation of nanoparticle self-assembly.
Angewandte Chemie (International ed. in English) 2006;45(19):3161-5.
2006: Jan Pilch; Carla M Franzin; Lynn M Knowles; Fernando J Ferrer; Francesca M Marassi; Erkki Ruoslahti
The anti-angiogenic peptide anginex disrupts the cell membrane.
Journal of molecular biology 2006;356(4):876-85.
2006: Jan Pilch; Darren M Brown; Masanobu Komatsu; Tero A H Järvinen; Meng Yang; David Peters; Robert M Hoffman; Erkki Ruoslahti
Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2800-4.
2005: Masanobu Komatsu; Erkki Ruoslahti
R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis.
Nature medicine 2005;11(12):1346-50.
2005: Lianglin Zhang; Jason A Hoffman; Erkki Ruoslahti
Molecular profiling of heart endothelial cells.
Circulation 2005;112(11):1601-11.
2005: Byung-Heon Lee; Erkki Ruoslahti
alpha5beta1 integrin stimulates Bcl-2 expression and cell survival through Akt, focal adhesion kinase, and Ca2+/calmodulin-dependent protein kinase IV.
Journal of cellular biochemistry 2005;95(6):1214-23.
2005: Jih-Tung Pai; Erkki Ruoslahti
Identification of endothelial genes up-regulated in vivo.
Gene 2005;347(1):21-33.
2005: Maria E Akerman; Jan Pilch; David Peters; Erkki Ruoslahti
Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2040-5.
2005: Erkki Ruoslahti; Tasmia Duza; Lianglin Zhang
Vascular homing peptides with cell-penetrating properties.
Current pharmaceutical design 2005;11(28):3655-60.
2004: Kari Alitalo; Suresh Mohla; Erkki Ruoslahti
Lymphangiogenesis and cancer: meeting report.
Cancer research 2004;64(24):9225-9.
2004: Pirjo Laakkonen; Maria E Akerman; Hector Biliran; Meng Yang; Fernando Ferrer; Terhi Karpanen; Robert M Hoffman; Erkki Ruoslahti
Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9381-6.
2004: Darren M Brown; Surya De; Erkki Ruoslahti
Drug identification through in vivo screening of chemical libraries.
Chembiochem : a European journal of chemical biology 2004;5(6):871-5.
2004: Darren M Brown; Erkki Ruoslahti
Metadherin, a cell surface protein in breast tumors that mediates lung metastasis.
Cancer cell 2004;5(4):365-74.
2004: Yiwen Jan; Michelle Matter; Jih-tung Pai; Yen-Liang Chen; Jan Pilch; Masanobu Komatsu; Edgar Ong; Minoru Fukuda; Erkki Ruoslahti
A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors.
Cell 2004;116(5):751-62.
2004: Jose M de Pereda; William F Waas; Yiwen Jan; Erkki Ruoslahti; Paul Schimmel; Jaime Pascual
Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity.
The Journal of biological chemistry 2004;279(9):8111-5.
2004: Ghiabe H Guibinga; Frederick L Hall; Erlinda M Gordon; Erkki Ruoslahti; Theodore Friedmann
Ligand-modified vesicular stomatitis virus glycoprotein displays a temperature-sensitive intracellular trafficking and virus assembly phenotype.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(1):76-84.
2003: Sven Christian; Jan Pilch; Maria E Akerman; Kimmo Porkka; Pirjo Laakkonen; Erkki Ruoslahti
Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels.
The Journal of cell biology 2003;163(4):871-8.
2003: Erkki Ruoslahti
The RGD story: a personal account.
Matrix biology : journal of the International Society for Matrix Biology 2003;22(6):459-65.
2003: Johanna A Joyce; Pirjo Laakkonen; Michele Bernasconi; Gabriele Bergers; Erkki Ruoslahti; Douglas Hanahan
Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis.
Cancer cell 2003;4(5):393-403.
2003: Jason A Hoffman; Enrico Giraudo; Mallika Singh; Lianglin Zhang; Masahiro Inoue; Kimmo Porkka; Douglas Hanahan; Erkki Ruoslahti
Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma.
Cancer cell 2003;4(5):383-91.
2003: Ming Yi; Takao Sakai; Reinhard Fassler; Erkki Ruoslahti
Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11435-8.
2003: Klára Briknarová; Maria E Akerman; David W Hoyt; Erkki Ruoslahti; Kathryn R Ely
Anastellin, an FN3 fragment with fibronectin polymerization activity, resembles amyloid fibril precursors.
Journal of molecular biology 2003;332(1):205-15.
2003: Naoki Itano; Shu-ichi Okamoto; Dongxian Zhang; Stuart A Lipton; Erkki Ruoslahti
Cell spreading controls endoplasmic and nuclear calcium: a physical gene regulation pathway from the cell surface to the nucleus.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5181-6.
2002: Erkki Ruoslahti
Drug targeting to specific vascular sites.
Drug discovery today 2002;7(22):1138-43.
2002: Maria E Akerman; Warren C W Chan; Pirjo Laakkonen; Sangeeta N Bhatia; Erkki Ruoslahti
Nanocrystal targeting in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12617-21.
2002: Erkki Ruoslahti
Antiangiogenics meet nanotechnology.
Cancer cell 2002;2(2):97-8.
2002: Pirjo Laakkonen; Kimmo Porkka; Jason A Hoffman; Erkki Ruoslahti
A tumor-homing peptide with a targeting specificity related to lymphatic vessels.
Nature medicine 2002;8(7):751-5.
2002: Kimmo Porkka; Pirjo Laakkonen; Jason A Hoffman; Michele Bernasconi; Erkki Ruoslahti
A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7444-9.
2002: Markus Essler; Erkki Ruoslahti
Molecular specialization of breast vasculature: a breast-homing phage-displayed peptide binds to aminopeptidase P in breast vasculature.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2252-7.
2002: Wadih Arap; Wolfgang Haedicke; Michele Bernasconi; Renate Kain; Daniel Rajotte; Stan Krajewski; H Michael Ellerby; Dale E Bredesen; Renata Pasqualini; Erkki Ruoslahti
Targeting the prostate for destruction through a vascular address.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1527-31.
2002: Erkki Ruoslahti
Specialization of tumour vasculature.
Nature reviews. Cancer 2002;2(2):83-90.
2002: June X Zou; Yanqiu Liu; Elena B Pasquale; Erkki Ruoslahti
Activated SRC oncogene phosphorylates R-ras and suppresses integrin activity.
The Journal of biological chemistry 2002;277(3):1824-7.
2001: Michelle Matter; Erkki Ruoslahti
A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription.
The Journal of biological chemistry 2001;276(30):27757-63.
2001: Nuria Assa-Munt; Xin Jia; Pirjo Laakkonen; Erkki Ruoslahti
Solution structures and integrin binding activities of an RGD peptide with two isomers.
Biochemistry 2001;40(8):2373-8.
2001: M Yi; Erkki Ruoslahti
A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):620-4.
2001: Danielle M Gerlag; E Borges; Paul P Tak; H Michael Ellerby; Dale E Bredesen; Renata Pasqualini; Erkki Ruoslahti; Gary S Firestein
Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature.
Arthritis research 2001;3(6):357-61.
2000: E Borges; Yiwen Jan; Erkki Ruoslahti
Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain.
The Journal of biological chemistry 2000;275(51):39867-73.
2000: B Wang; June X Zou; B Ek-Rylander; Erkki Ruoslahti
R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras.
The Journal of biological chemistry 2000;275(7):5222-7.
2000: Renata Pasqualini; Erkki Koivunen; Renate Kain; Johanna Lahdenranta; M Sakamoto; A Stryhn; R A Ashmun; Linda H. Shapiro; Wadih Arap; Erkki Ruoslahti
Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.
Cancer research 2000;60(3):722-7.
2000: M N Fukuda; Chikara Ohyama; Kevin P Lowitz; O Matsuo; Renata Pasqualini; Erkki Ruoslahti; Michiko N Fukuda
A peptide mimic of E-selectin ligand inhibits sialyl Lewis X-dependent lung colonization of tumor cells.
Cancer research 2000;60(2):450-6.
2000: Andreas H Zisch; C Pazzagli; Andrew L Freeman; M Schneller; M Hadman; J W Smith; Erkki Ruoslahti; Elena B Pasquale
Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses.
Oncogene 2000;19(2):177-87.
2000: Erkki Ruoslahti; Daniel Rajotte
An address system in the vasculature of normal tissues and tumors.
Annual review of immunology 2000;18():813-27.
1999: June X Zou; B Wang; Matthew S Kalo; Andreas H Zisch; Elena B Pasquale; Erkki Ruoslahti
An Eph receptor regulates integrin activity through R-Ras.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):13813-8.
1999: H Michael Ellerby; Wadih Arap; Lisa M Ellerby; Renate Kain; RL Andrusiak; G D Rio; Stan Krajewski; C R Lombardo; R Rao; Erkki Ruoslahti; Dale E Bredesen; Renata Pasqualini
Anti-cancer activity of targeted pro-apoptotic peptides.
Nature medicine 1999;5(9):1032-8.
1999: Erkki Koivunen; Wadih Arap; Heli Valtanen; A Rainisalo; Oula Penate Medina; Päivi Heikkilä; C Kantor; Carl G Gahmberg; Tuula Salo; Yrjö T Konttinen; Timo Sorsa; Erkki Ruoslahti; Renata Pasqualini
Tumor targeting with a selective gelatinase inhibitor.
Nature biotechnology 1999;17(8):768-74.
1999: MA Burg; Renata Pasqualini; Wadih Arap; Erkki Ruoslahti; William B Stallcup
NG2 proteoglycan-binding peptides target tumor neovasculature.
Cancer research 1999;59(12):2869-74.
1999: Daniel Rajotte; Erkki Ruoslahti
Membrane dipeptidase is the receptor for a lung-targeting peptide identified by in vivo phage display.
The Journal of biological chemistry 1999;274(17):11593-8.
1999: Erkki Ruoslahti
Fibronectin and its integrin receptors in cancer.
Advances in cancer research 1999;76():1-20.
1998: Wadih Arap; Renata Pasqualini; Erkki Ruoslahti
Chemotherapy targeted to tumor vasculature.
Current opinion in oncology 1998;10(6):560-5.
1998: S Bourdoulous; G Orend; D A MacKenna; R Pasqualini; Erkki Ruoslahti
Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression.
The Journal of cell biology 1998;143(1):267-76.
1998: Daniel Rajotte; Wadih Arap; Martin Hagedorn; Erkki Koivunen; Renata Pasqualini; Erkki Ruoslahti
Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display.
The Journal of clinical investigation 1998;102(2):430-7.
1998: Michelle Matter; Zhuohua Zhang; C Nordstedt; Erkki Ruoslahti
The alpha5beta1 integrin mediates elimination of amyloid-beta peptide and protects against apoptosis.
The Journal of cell biology 1998;141(4):1019-30.
1998: G Orend; Tony Hunter; Erkki Ruoslahti
Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells.
Oncogene 1998;16(20):2575-83.
1998: Wadih Arap; Renata Pasqualini; Erkki Ruoslahti
Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model.
Science (New York, N.Y.) 1998;279(5349):377-80.
1998: D A MacKenna; F Dolfi; Kristiina Vuori; Erkki Ruoslahti
Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts.
The Journal of clinical investigation 1998;101(2):301-10.
1997: Erkki Ruoslahti; Eva Engvall
Integrins and vascular extracellular matrix assembly.
The Journal of clinical investigation 1997;100(11 Suppl):S53-6.
1997: A Aspberg; R Miura; S Bourdoulous; M Shimonaka; D Heinegârd; Melitta Schachner; Erkki Ruoslahti; Yu Yamaguchi
The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10116-21.
1997: M Schneller; Kristiina Vuori; Erkki Ruoslahti
Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF.
The EMBO journal 1997;16(18):5600-7.
1997: Renata Pasqualini; Erkki Koivunen; Erkki Ruoslahti
Alpha v integrins as receptors for tumor targeting by circulating ligands.
Nature biotechnology 1997;15(6):542-6.
1997: Erkki Ruoslahti; Eva Engvall
Integrins and vascular extracellular matrix assembly.
The Journal of clinical investigation 1997;99(6):1149-52.
1996: Renata Pasqualini; Erkki Ruoslahti
Searching for a molecular address in the brain.
Molecular psychiatry 1996;1(6):421-2.
1996: Renata Pasqualini; S Bourdoulous; Erkki Koivunen; V L Woods; Erkki Ruoslahti
A polymeric form of fibronectin has antimetastatic effects against multiple tumor types.
Nature medicine 1996;2(11):1197-203.
1996: Erkki Ruoslahti
Brain extracellular matrix.
Glycobiology 1996;6(5):489-92.
1996: Kristiina Vuori; H Hirai; S Aizawa; Erkki Ruoslahti
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.
Molecular and cellular biology 1996;16(6):2606-13.
1996: Zhuohua Zhang; Kristiina Vuori; Hong-Gang Wang; John C Reed; Erkki Ruoslahti
Integrin activation by R-ras.
Cell 1996;85(1):61-9.
1996: Renata Pasqualini; Erkki Ruoslahti
Organ targeting in vivo using phage display peptide libraries.
Nature 1996;380(6572):364-6.
1989: E M Salonen; Antti Vaheri; J Pöllänen; R Stephens; P Andreasen; Michael Mayer; Keld Danø; J Gailit; Erkki Ruoslahti
Interaction of plasminogen activator inhibitor (PAI-1) with vitronectin.
The Journal of biological chemistry 1989;264(11):6339-43.