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Alain Rupin

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Alain Rupin; Marie-Odile Vallez; Guillaume De Nanteuil; P Gloanec; I Marx; P Mennecier; Tony J Verbeuren
S35972, a direct-acting thrombin inhibitor with high oral bioavailability and antithrombotic efficacy.
Nicolas Clavreul; Delphine Magard; Patricia Sansilvestri-Morel; Tony J Verbeuren; Alain Rupin
(Pro)renin promotes fibrosis gene expression in HEK cells through a Nox4-dependent mechanism.
Amandine Jaulmes; Patricia Sansilvestri-Morel; Gaëlle Rolland-Valognes; Fabienne Bernhardt; Roger Gaertner; Brian P Lockhart; Alex Cordi; Michel Wierzbicki; Alain Rupin; Tony J Verbeuren
Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells.

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All Publications

2011: Alain Rupin; Marie-Odile Vallez; Guillaume De Nanteuil; P Gloanec; I Marx; P Mennecier; Tony J Verbeuren
S35972, a direct-acting thrombin inhibitor with high oral bioavailability and antithrombotic efficacy.
Journal of thrombosis and haemostasis : JTH 2011;9(7):1375-82.
2011: Nicolas Clavreul; Delphine Magard; Patricia Sansilvestri-Morel; Tony J Verbeuren; Alain Rupin
(Pro)renin promotes fibrosis gene expression in HEK cells through a Nox4-dependent mechanism.
American journal of physiology. Renal physiology 2011;300(6):F1310-8.
2009: Amandine Jaulmes; Patricia Sansilvestri-Morel; Gaëlle Rolland-Valognes; Fabienne Bernhardt; Roger Gaertner; Brian P Lockhart; Alex Cordi; Michel Wierzbicki; Alain Rupin; Tony J Verbeuren
Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells.
Thrombosis research 2009;124(4):439-46.
2009: Erwan Ayral; Philippe Gloanec; Gilbert Bergé; Guillaume De Nanteuil; Philippe Mennecier; Alain Rupin; Tony J Verbeuren; Pierre Fulcrand; Jean Martinez; Jean-François Hernandez
Design, synthesis, and biological evaluation of 1,5-benzothiazepine-4-one derivatives targeting factor VIIa/tissue factor.
Bioorganic & medicinal chemistry letters 2009;19(5):1386-91.
2008: Isabelle Marx; Olivier D Christophe; Peter J Lenting; Alain Rupin; Marie-Odile Vallez; Tony J Verbeuren; Cécile V Denis
Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa.
Blood 2008;112(3):603-9.
2008: Olivier Chose; Patricia Sansilvestri-Morel; Cécile Badier-Commander; Fabienne Bernhardt; Jean-Noël Fabiani; Alain Rupin; Tony J Verbeuren
Distinct role of nox1, nox2, and p47phox in unstimulated versus angiotensin II-induced NADPH oxidase activity in human venous smooth muscle cells.
Journal of cardiovascular pharmacology 2008;51(2):131-9.
2008: Stephen Hanessian; Sébastien Guesné; Ludivine Riber; Julien Marin; Alain Benoist; Philippe Mennecier; Alain Rupin; Tony J Verbeuren; Guillaume De Nanteuil
Targeting ACE and ECE with dual acting inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(3):1058-62.
2008: Alain Rupin; Roger Gaertner; Philippe Mennecier; Isabelle Richard; Alain Benoist; Guillaume De Nanteuil; Tony J Verbeuren
S35225 is a direct inhibitor of Plasminogen Activator Inhibitor type-1 activity in the blood.
Thrombosis research 2008;122(2):265-70.
2007: Patricia Sansilvestri-Morel; Florence Fioretti; Alain Rupin; Karim Senni; Jean-Noël Fabiani; Gaston Godeau; Tony J Verbeuren
Comparison of extracellular matrix in skin and saphenous veins from patients with varicose veins: does the skin reflect venous matrix changes?
Clinical science (London, England : 1979) 2007;112(4):229-39.
2006: Guillaume De Nanteuil; Philippe Gloanec; Suzette Béguin; peter giesen; Coenraad Hemker; Philippe Mennecier; Alain Rupin; Tony J Verbeuren
Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders.
Journal of medicinal chemistry 2006;49(17):5047-50.
2005: Patricia Sansilvestri-Morel; Alain Rupin; Nicolas D Jullien; Nathalie Lembrez; Patricia Mestries-Dubois; Jean-Noël Fabiani; Tony J Verbeuren
Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3.
Journal of vascular research 2005;42(5):388-98.
2004: Volker O Melichar; Delphine Behr-Roussel; Ulrike Zabel; L Otto Uttenthal; José Rodrigo; Alain Rupin; Tony J Verbeuren; Arun Kumar H S; Harald Schmidt
Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16671-6.
2004: Alain Rupin; Jérôme Paysant; Patricia Sansilvestri-Morel; Nathalie Lembrez; Jean-Michel Lacoste; Alex Cordi; Tony J Verbeuren
Role of NADPH oxidase-mediated superoxide production in the regulation of E-selectin expression by endothelial cells subjected to anoxia/reoxygenation.
Cardiovascular research 2004;63(2):323-30.
2004: Serge Simonet; Alain Rupin; Cécile Badier-Commander; Sophie Coumailleau; Delphine Behr-Roussel; Tony J Verbeuren
Evidence for superoxide anion generation in aortas of cholesterol-fed rabbits treated with L-arginine.
European journal of pharmacology 2004;492(2-3):211-6.
2003: Patricia Sansilvestri-Morel; Alain Rupin; Cécile Badier-Commander; Jean-Noël Fabiani; Tony J Verbeuren
Chronic venous insufficiency: dysregulation of collagen synthesis.
Angiology 2003;54 Suppl 1():S13-8.
2003: Guillaume De Nanteuil; Christine Lila-Ambroise; Alain Rupin; Marie-Odile Vallez; Tony J Verbeuren
New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation.
Bioorganic & medicinal chemistry letters 2003;13(10):1705-8.
2003: Axelle Arrault; Marlène Dubuisson; Sonia Gharbi; Cécile Marchand; Tony J Verbeuren; Alain Rupin; Alex Cordi; Eliete Bouskela; Jean-François Rees; Jacqueline Marchand-Brynaert
Protective effect of imidazolopyrazinone antioxidants on ischemia/reperfusion injury.
Bioorganic & medicinal chemistry letters 2003;13(4):653-6.
2002: Patricia Sansilvestri-Morel; Alain Rupin; Stéphane Jaisson; Jean-Noël Fabiani; Tony J Verbeuren; Paul M Vanhoutte
Synthesis of collagen is dysregulated in cultured fibroblasts derived from skin of subjects with varicose veins as it is in venous smooth muscle cells.
Circulation 2002;106(4):479-83.
2002: Delphine Behr-Roussel; Jacques Bernabe; Sandrine Compagnie; Alain Rupin; Tony J Verbeuren; Laurent Alexandre; François Giuliano
Distinct mechanisms implicated in atherosclerosis-induced erectile dysfunction in rabbits.
Atherosclerosis 2002;162(2):355-62.
2002: Jérôme Paysant; Alain Rupin; Tony J Verbeuren
Effect of NADPH oxidase inhibition on E-selectin expression induced by concomitant anoxia/reoxygenation and TNF-alpha.
Endothelium : journal of endothelial cell research 2002;9(4):263-71.
2001: Alain Rupin; F Martin; Marie-Odile Vallez; E Bonhomme; Tony J Verbeuren
Inactivation of plasminogen activator inhibitor-1 accelerates thrombolysis of a platelet-rich thrombus in rat mesenteric arterioles.
Thrombosis and haemostasis 2001;86(6):1528-31.
2001: Patricia Sansilvestri-Morel; Alain Rupin; Cécile Badier-Commander; P Kern; Jean-Noël Fabiani; Tony J Verbeuren; Paul M Vanhoutte
Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veins.
Journal of vascular research 2001;38(6):560-8.
2001: Antonio Cayatte; Alain Rupin; Jennifer M Oliver-Krasinski; Karlene A Maitland; Patricia Sansilvestri-Morel; Marie-Françoise Boussard; Michel Wierzbicki; Tony J Verbeuren; Richard A Cohen
S17834, a new inhibitor of cell adhesion and atherosclerosis that targets nadph oxidase.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(10):1577-84.
2001: Jérôme Paysant; Alain Rupin; Serge Simonet; Jean-Noël Fabiani; Tony J Verbeuren
Comparison of the contractile responses of human coronary bypass grafts and monkey arteries to human urotensin-II.
Fundamental & clinical pharmacology 2001;15(4):227-31.
2000: Alain Rupin; Delphine Behr-Roussel; Tony J Verbeuren
Long-lasting cyclic guanosine-3',5'-monophosphate accumulation in the medium of cultured smooth muscle cells from atherosclerotic rabbit aortas in response to exogenous or endogenous nitric oxide.
Fundamental & clinical pharmacology 2000;14(5):453-9.
2000: Delphine Behr-Roussel; Alain Rupin; Serge Simonet; E Bonhomme; S Coumailleau; Alex Cordi; B Serkiz; Jean-Noël Fabiani; Tony J Verbeuren
Effect of chronic treatment with the inducible nitric oxide synthase inhibitor N-iminoethyl-L-lysine or with L-arginine on progression of coronary and aortic atherosclerosis in hypercholesterolemic rabbits.
Circulation 2000;102(9):1033-8.
2000: Delphine Behr-Roussel; Alain Rupin; Serge Simonet; Jean-Noël Fabiani; Tony J Verbeuren
Urinary nitrate excretion in cholesterol-fed rabbits: effect of a chronic treatment by N-iminoethyl-L-lysine, a selective inhibitor of inducible nitric oxide synthase.
European journal of pharmacology 2000;388(3):275-9.
2000: Delphine Behr-Roussel; Alain Rupin; Patricia Sansilvestri-Morel; Jean-Noël Fabiani; Tony J Verbeuren
Histochemical evidence for inducible nitric oxide synthase in advanced but non-ruptured human atherosclerotic carotid arteries.
The Histochemical journal 2000;32(1):41-51.
1999: Delphine Behr-Roussel; Alain Rupin; Jean-Noël Fabiani; Tony J Verbeuren
Distribution and prevalence of inducible nitric oxide synthase in atherosclerotic vessels of long-term cholesterol-fed rabbits.
Atherosclerosis 1999;142(2):335-44.
1998: Patricia Sansilvestri-Morel; I Nonotte; M P Fournet-Bourguignon; Alain Rupin; Jean-Noël Fabiani; Tony J Verbeuren; Paul M Vanhoutte
Abnormal deposition of extracellular matrix proteins by cultured smooth muscle cells from human varicose veins.
Journal of vascular research 1998;35(2):115-23.
1997: Alain Rupin; P Mennecier; C Lila; Guillaume De Nanteuil; Tony J Verbeuren
Selection of S18326 as a new potent and selective boronic acid direct thrombin inhibitor.
Thrombosis and haemostasis 1997;78(4):1221-7.
1996: Alain Rupin; Delphine Behr-Roussel; Tony J Verbeuren
Increased activity of guanylate cyclase in the atherosclerotic rabbit aorta: role of non-endothelial nitric oxide synthases.
British journal of pharmacology 1996;119(6):1233-8.
1995: Guillaume De Nanteuil; P Gloanec; C Lila; B Portevin; A Boudon; Alain Rupin; Tony J Verbeuren
New tripeptidic thrombin inhibitors. Influence of P2 and P3 residues on activity and selectivity.
Bioorganic & medicinal chemistry 1995;3(8):1019-24.
1995: Alain Rupin; P Mennecier; Guillaume De Nanteuil; Michel Laubie; Tony J Verbeuren
A screening procedure to evaluate the anticoagulant activity and the kinetic behaviour of direct thrombin inhibitors.
Thrombosis research 1995;78(3):217-25.