FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Heikki Ruskoaho

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Disorders

Physiology

Co-author Network

Publications

TOP 3
J Aro; Mika Ilves; E Koivisto; V-P Ronkainen; Heikki Ruskoaho; István Szokodi; Olli Tenhunen; Heikki Tokola; Jaana Rysä
Regulation of cardiac melusin gene expression by hypertrophic stimuli in the rat.
Erja Mustonen; Heikki Ruskoaho; Jaana Rysä
Thrombospondins, potential drug targets for cardiovascular diseases.
Erja Mustonen; Heikki Ruskoaho; Jaana Rysä
Thrombospondin-4, tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14: novel extracellular matrix modulating factors in cardiac remodelling.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Heikki Ruskoaho (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: J Aro; Mika Ilves; E Koivisto; V-P Ronkainen; Heikki Ruskoaho; István Szokodi; Olli Tenhunen; Heikki Tokola; Jaana Rysä
Regulation of cardiac melusin gene expression by hypertrophic stimuli in the rat.
Acta physiologica (Oxford, England) 2013;207(3):470-84.
2013: Erja Mustonen; Heikki Ruskoaho; Jaana Rysä
Thrombospondins, potential drug targets for cardiovascular diseases.
Basic & clinical pharmacology & toxicology 2013;112(1):4-12.
2012: Erja Mustonen; Heikki Ruskoaho; Jaana Rysä
Thrombospondin-4, tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14: novel extracellular matrix modulating factors in cardiac remodelling.
Annals of medicine 2012;44(8):793-804.
2012: A Perjés; Heikki Ruskoaho; Réka Skoumal; Sándor Szabados; Attila Cziráki; Attila Kónyi; A M Kubin; István Szokodi
Physiological regulation of cardiac contractility by endogenous reactive oxygen species.
Acta physiologica (Oxford, England) 2012;205(1):26-40.
2012: Laura Vainio; Tarja Alakoski; Leena Kaikkonen; Johanna Magga; Abel Perjes; Jarkko Piuhola; Heikki Ruskoaho; Niilo Ryti; Raisa Serpi; Istvan Szokodi; Risto Kerkelä
Neuronostatin, a novel peptide encoded by somatostatin gene, regulates cardiac contractile function and cardiomyocyte survival.
The Journal of biological chemistry 2012;287(7):4572-80.
2012: Anne-Mari Moilanen; Erja Mustonen; Juha Näpänkangas; Jaana Rysä; Tuula Salo; Raisa Serpi; M Sutinen; Zoltán Szabò; Olli Tenhunen; Jani Aro; Heikki Ruskoaho
(Pro)renin receptor triggers distinct angiotensin II-independent extracellular matrix remodeling and deterioration of cardiac function.
PloS one 2012;7(7):e41404.
2012: Hannu-Ville Leskelä; Tuomas Peltonen; Heikki Ruskoaho; Panu Taskinen; Olli Vuolteenaho; Marja-Kaisa Koivula; Petri Lehenkari
Tezosentan inhibits uptake of proinflammatory endothelin-1 in stenotic aortic valves.
The Journal of heart valve disease 2012;21(1):23-30.
2012: Virva Pohjolainen; Ilkka Pörsti; Jaana Rysä; Raisa Serpi; Arttu Eräranta; Mika Ilves; Peeter Kööbi; Juha Näpänkangas; Heikki Ruskoaho
Left ventricular periostin gene expression is associated with fibrogenesis in experimental renal insufficiency.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27(1):115-22.
2011: Liisa Laatio; Elisa Lappi-Blanco; Paivi Myllynen; Heikki Ruskoaho; Jaana Rysä; Raisa Serpi; Kirsi Vähäkangas; Mika Ilves; Ulla Puistola
BMP-4 expression has prognostic significance in advanced serous ovarian carcinoma and is affected by cisplatin in OVCAR-3 cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2011;32(5):985-95.
2011: Tuomas Peltonen; Heikki Ruskoaho; Juha Näpänkangas; Pasi Ohtonen; Pauli Ohukainen; Panu Taskinen
Statin treatment and gene expression of anti-atherogenic factor C-type natriuretic peptide system in stenotic aortic valves.
The Journal of heart valve disease 2011;20(5):545-51.
2011: Elina Koivisto; Theresa Majalahti; Jani Aro; Laura Karkkola; Risto Kerkelä; Heikki Tokola; Heikki Ruskoaho
M-CAT element mediates mechanical stretch-activated transcription of B-type natriuretic peptide via ERK activation.
Canadian journal of physiology and pharmacology 2011;89(8):539-50.
2011: Anne-Mari Moilanen; Erja Mustonen; Jani Aro; Hanna Leskinen; Jouko Mikael Levijoki; Aki Manninen; Jaana Rysä; Raisa Serpi; Heikki Tokola; Olli Vuolteenaho; Heikki Ruskoaho
Intramyocardial BNP gene delivery improves cardiac function through distinct context-dependent mechanisms.
Circulation. Heart failure 2011;4(4):483-95.
2011: Elina Koivisto; Leena Kaikkonen; Heikki Tokola; Sampsa Pikkarainen; Jani Aro; Harri Pennanen; Teemu Karvonen; Jaana Rysä; Risto Kerkelä; Heikki Ruskoaho
Distinct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms.
Molecular and cellular endocrinology 2011;338(1-2):18-27.
2011: Anna-Maria Kubin; Réka Skoumal; Pasi Tavi; Attila Kónyi; Abel Perjés; Hanna Leskinen; Heikki Ruskoaho; István Szokodi
Role of reactive oxygen species in the regulation of cardiac contractility.
Journal of molecular and cellular cardiology 2011;50(5):884-93.
2011: Tuomas Peltonen; Juha Näpänkangas; Pasi Ohtonen; Jani Aro; Jenni Peltonen; Ylermi Soini; Tatu Juvonen; Jari Satta; Heikki Ruskoaho; Panu Taskinen
(Pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis.
Atherosclerosis 2011;216(1):35-43.
2011: Réka Skoumal; Miklós Tóth; Raisa Serpi; Jaana Rysä; Hanna Leskinen; Johanna Ulvila; Tarja Saiho; Jani Aro; Heikki Ruskoaho; István Szokodi; Risto Kerkelä
Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity.
Journal of molecular and cellular cardiology 2011;50(4):634-41.
2011: Risto Kerkelä; Mika Ilves; Sampsa Pikkarainen; Heikki Tokola; Veli-Pekka Ronkainen; Theresa Majalahti; Juhani Leppäluoto; Olli Vuolteenaho; Heikki Ruskoaho
Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;300(1):R140-9.
2011: Raisa Serpi; Anna-Maria Tolonen; Jenni Huusko; Jaana Rysä; Olli Tenhunen; Seppo Ylä-Herttuala; Heikki Ruskoaho
Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats.
Cardiovascular research 2011;89(1):204-13.
2010: Minna Ala-Kopsala; Anne-Mari Moilanen; Jaana Rysä; Heikki Ruskoaho; Olli Vuolteenaho
Characterization of molecular forms of N-terminal B-type natriuretic peptide in vitro.
Clinical chemistry 2010;56(12):1822-9.
2010: Karolina Rasi; Jarkko Piuhola; Marcus Czabanka; Raija Sormunen; Mika Ilves; Hanna Leskinen; Jaana Rysä; Risto Kerkelä; Paul Janmey; Ritva Heljasvaara; Keijo Peuhkurinen; Olli Vuolteenaho; Heikki Ruskoaho; Peter Vajkoczy; Taina Pihlajaniemi; Lauri Eklund
Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy.
Circulation research 2010;107(10):1241-52.
2010: Erja Mustonen; Hanna Leskinen; Jani Aro; Marja Luodonpää; Olli Vuolteenaho; Heikki Ruskoaho; Jaana Rysä
Metoprolol treatment lowers thrombospondin-4 expression in rats with myocardial infarction and left ventricular hypertrophy.
Basic & clinical pharmacology & toxicology 2010;107(3):709-17.
2010: Jaana Rysä; Olli Tenhunen; Raisa Serpi; Ylermi Soini; Mona Nemer; Hanna Leskinen; Heikki Ruskoaho
GATA-4 is an angiogenic survival factor of the infarcted heart.
Circulation. Heart failure 2010;3(3):440-50.
2010: E Mustonen; H Säkkinen; H Tokola; E Isopoussu; J Aro; Hanna Leskinen; Heikki Ruskoaho; Jaana Rysä
Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats.
Acta physiologica (Oxford, England) 2010;199(1):11-22.
2010: Hanne Luosujärvi; Jani Aro; Heikki Tokola; Hanna Leskinen; Olli Tenhunen; Réka Skoumal; István Szokodi; Heikki Ruskoaho; Jaana Rysä
A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart.
Blood pressure 2010;19(1):54-63.
2010: A Ola; Risto Kerkelä; Heikki Tokola; Sampsa Pikkarainen; R Skoumal; Olli Vuolteenaho; Heikki Ruskoaho
The mixed-lineage kinase 1-3 signalling pathway regulates stress response in cardiac myocytes via GATA-4 and AP-1 transcription factors.
British journal of pharmacology 2010;159(3):717-25.
2010: Attila Kónyi; Réka Skoumal; Anna-Maria Kubin; Gábor Füredi; Abel Perjés; Klára Farkasfalvi; Zsolt Sárszegi; Ferenc Horkay; Iván G Horváth; Miklós Tóth; Heikki Ruskoaho; István Szokodi
Prolactin-releasing peptide regulates cardiac contractility.
Regulatory peptides 2010;159(1-3):9-13.
2009: Raisa Serpi; Anna-Maria Tolonen; Olli Tenhunen; Oskari Pieviläinen; Anna-Maria Kubin; Tommi Vaskivuo; Ylermi Soini; Risto Kerkelä; Hanna Leskinen; Heikki Ruskoaho
Divergent effects of losartan and metoprolol on cardiac remodeling, c-kit+ cells, proliferation and apoptosis in the left ventricle after myocardial infarction.
Clinical and translational science 2009;2(6):422-30.
2009: Tuomas Peltonen; Juha Näpänkangas; Olli Vuolteenaho; Pasi Ohtonen; Ylermi Soini; Tatu Juvonen; Jari Satta; Heikki Ruskoaho; Panu Taskinen
Apelin and its receptor APJ in human aortic valve stenosis.
The Journal of heart valve disease 2009;18(6):644-52.
2009: inka liesmaa; Hanna Leskinen; Jorma O Kokkonen; Heikki Ruskoaho; Petri T Kovanen; Ken A Lindstedt
Hypoxia-induced expression of bradykinin type-2 receptors in endothelial cells triggers NO production, cell migration, and angiogenesis.
Journal of cellular physiology 2009;221(2):359-66.
2009: T Majalahti; Heikki Tokola; Heikki Ruskoaho; Olli Vuolteenaho
Characterization of promoter elements required for cardiac chamber-specific expression.
Molecular and cellular endocrinology 2009;307(1-2):50-6.
2009: Sudhir Kurl; Minna Ala-Kopsala; Heikki Ruskoaho; Timo H Mäkikallio; Kristiina Nyyssönen; Olli Vuolteenaho; Juhani Sivenius; Jukka T Salonen; Jari A Laukkanen
Plasma N-terminal fragments of natriuretic peptides predict the risk of stroke and atrial fibrillation in men.
Heart (British Cardiac Society) 2009;95(13):1067-71.
2009: Erja Mustonen; Virva Pohjolainen; Jani Aro; Sampsa Pikkarainen; Hanna Leskinen; Heikki Ruskoaho; Jaana Rysä
Upregulation of cardiac matrix Gla protein expression in response to hypertrophic stimuli.
Blood pressure 2009;18(5):286-93.
2009: Suvi T Ruohonen; Eriika Savontaus; Petteri Rinne; Joana Rosmaninho-Salgado; Claudia Cavadas; Heikki Ruskoaho; Markku Koulu; Ullamari Pesonen
Stress-induced hypertension and increased sympathetic activity in mice overexpressing neuropeptide Y in noradrenergic neurons.
Neuroendocrinology 2009;89(3):351-60.
2009: Tuomas Peltonen; Panu Taskinen; Juha Näpänkangas; Hanna Leskinen; Pasi Ohtonen; Ylermi Soini; Tatu Juvonen; Jari Satta; Olli Vuolteenaho; Heikki Ruskoaho
Increase in tissue endothelin-1 and ETA receptor levels in human aortic valve stenosis.
European heart journal 2009;30(2):242-9.
2008: Virva Pohjolainen; Panu Taskinen; Ylermi Soini; Jaana Rysä; Mika Ilves; Tatu Juvonen; Heikki Ruskoaho; Hanna Leskinen; Jari Satta
Noncollagenous bone matrix proteins as a part of calcific aortic valve disease regulation.
Human pathology 2008;39(11):1695-701.
2008: István Szokodi; Risto Kerkelä; Anna-Maria Kubin; Balázs Sármán; Sampsa Pikkarainen; Attila Kónyi; Iván G Horváth; Lajos Papp; Miklós Tóth; Réka Skoumal; Heikki Ruskoaho
Functionally opposing roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the regulation of cardiac contractility.
Circulation 2008;118(16):1651-8.
2008: Erja Mustonen; Jani Aro; Jutta Puhakka; Mika Ilves; Ylermi Soini; Hanna Leskinen; Heikki Ruskoaho; Jaana Rysä
Thrombospondin-4 expression is rapidly upregulated by cardiac overload.
Biochemical and biophysical research communications 2008;373(2):186-91.
2008: Hanna Leskinen; Tanja Rauma-Pinola; István Szokodi; Risto Kerkelä; Sampsa Pikkarainen; Paavo Uusimaa; Timo Hautala; Olli Vuolteenaho; Heikki Ruskoaho
Adaptive or maladaptive response to adenoviral adrenomedullin gene transfer is context-dependent in the heart.
The journal of gene medicine 2008;10(8):867-77.
2008: Pirkko Sallinen; Satu Mänttäri; Hanna Leskinen; Olli Vakkuri; Heikki Ruskoaho; Seppo Saarela
Long-term postinfarction melatonin administration alters the expression of DHPR, RyR2, SERCA2, and MT2 and elevates the ANP level in the rat left ventricle.
Journal of pineal research 2008;45(1):61-9.
2008: Emmanouil Karavalakis; Arttu Eräranta; Tuija I Vehmas; Jenni K Koskela; Peeter Kööbi; Jukka Mustonen; Onni Niemelä; Jaana Rysä; Heikki Ruskoaho; Ilkka Pörsti
Paricalcitol treatment and arterial tone in experimental renal insufficiency.
Nephron. Experimental nephrology 2008;109(3):e84-93.
2007: J M Repo; Immo Rantala; Teemu Honkanen; Jukka Mustonen; Peeter Kööbi; Anna Tahvanainen; Onni Niemelä; Ilkka Tikkanen; Jaana Rysä; Heikki Ruskoaho; Ilkka Pörsti
Paricalcitol aggravates perivascular fibrosis in rats with renal insufficiency and low calcitriol.
Kidney international 2007;72(8):977-84.
2007: Tuomas O Peltonen; Panu Taskinen; Ylermi Soini; Jaana Rysä; Jarkko Ronkainen; Pasi Ohtonen; Jari Satta; Tatu Juvonen; Heikki Ruskoaho; Hanna Leskinen
Distinct downregulation of C-type natriuretic peptide system in human aortic valve stenosis.
Circulation 2007;116(11):1283-9.
2007: Balázs Sármán; Réka Skoumal; Hanna Leskinen; Jaana Rysä; Mika Ilves; Ylermi Soini; Juha Tuukkanen; Sampsa Pikkarainen; Zoltán Lakó-Futó; Beatrix Sármán; Lajos Papp; Rudolf de Châtel; Miklós Tóth; Heikki Ruskoaho; István Szokodi
Nuclear factor-kappaB signaling contributes to severe, but not moderate, angiotensin II-induced left ventricular remodeling.
Journal of hypertension 2007;25(9):1927-39.
2007: Pirkko Sallinen; Satu Mänttäri; Hanna Leskinen; Mika Ilves; Heikki Ruskoaho; Seppo Saarela
Time course of changes in the expression of DHPR, RyR(2), and SERCA2 after myocardial infarction in the rat left ventricle.
Molecular and cellular biochemistry 2007;303(1-2):97-103.
2007: Tamás Breuer; Erzsébet Sápi; Réka Skoumal; Miklós Tóth; Minna Ala-Kopsala; Olli Vuolteenaho; Juhani Leppäluoto; Heikki Ruskoaho; András Szatmári; Andrea Székely
N-terminal probrain natriuretic peptide level inversely correlates with cardiac index after arterial switch operation in neonates.
Paediatric anaesthesia 2007;17(8):782-8.
2007: Theresa Majalahti; Maria Suo-Palosaari; Balázs Sármán; Nina Hautala; Sampsa Pikkarainen; Heikki Tokola; Olli Vuolteenaho; Jun Wang; Pierre Paradis; Mona Nemer; Heikki Ruskoaho
Cardiac BNP gene activation by angiotensin II in vivo.
Molecular and cellular endocrinology 2007;273(1-2):59-67.
2007: Pirkko Sallinen; Satu Mänttäri; Hanna Leskinen; Mika Ilves; Olli Vakkuri; Heikki Ruskoaho; Seppo Saarela
The effect of myocardial infarction on the synthesis, concentration and receptor expression of endogenous melatonin.
Journal of pineal research 2007;42(3):254-60.
2007: Réka Skoumal; István Szokodi; Jani Aro; Gábor Földes; Mónika Göoz; Leila Seres; Balázs Sármán; Zoltán Lakó-Futó; Lajos Papp; Olli Vuolteenaho; Juhani Leppäluoto; Rudolf de Châtel; Heikki Ruskoaho; Miklós Tóth
Involvement of endogenous ouabain-like compound in the cardiac hypertrophic process in vivo.
Life sciences 2007;80(14):1303-10.
2007: Jarkko Piuhola; István Szokodi; Heikki Ruskoaho
Endothelin-1 and angiotensin II contribute to BNP but not c-fos gene expression response to elevated load in isolated mice hearts.
Biochimica et biophysica acta 2007;1772(3):338-44.
2006: Peeter Kööbi; Tuija I Vehmas; Pasi Jolma; Jarkko Kalliovalkama; Meng Fan; Onni Niemelä; Heikki Saha; Mika Kähönen; Pauli Ylitalo; Jaana Rysä; Heikki Ruskoaho; Ilkka Pörsti
High-calcium vs high-phosphate intake and small artery tone in advanced experimental renal insufficiency.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006;21(10):2754-61.
2006: Olli Tenhunen; Jaana Rysä; Mika Ilves; Ylermi Soini; Heikki Ruskoaho; Hanna Leskinen
Identification of cell cycle regulatory and inflammatory genes as predominant targets of p38 mitogen-activated protein kinase in the heart.
Circulation research 2006;99(5):485-93.
2006: Olli Tenhunen; Ylermi Soini; Mika Ilves; Jaana Rysä; Juha Tuukkanen; Raisa Serpi; Harri Pennanen; Heikki Ruskoaho; Hanna Leskinen
p38 Kinase rescues failing myocardium after myocardial infarction: evidence for angiogenic and anti-apoptotic mechanisms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(11):1907-9.
2006: Heidi Vierimaa; Jarkko Ronkainen; Heikki Ruskoaho; Olli Vuolteenaho
Synergistic activation of salmon cardiac function by endothelin and beta-adrenergic stimulation.
American journal of physiology. Heart and circulatory physiology 2006;291(3):H1360-70.
2006: Gábor Földes; Szilvia Vajda; Zoltán Lakó-Futó; Balázs Sármán; Réka Skoumal; Mika Ilves; Rudolf de Châtel; István Karádi; Miklós Tóth; Heikki Ruskoaho; István Leprán
Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type.
Journal of lipid research 2006;47(6):1219-26.
2006: Sampsa Pikkarainen; Heikki Tokola; Risto Kerkelä; Mika Ilves; Markus Makinen; Hans-Dieter Orzechowski; Martin Paul; Olli Vuolteenaho; Heikki Ruskoaho
Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(6):R1639-45.
2006: Jari A Laukkanen; Sudhir Kurl; Minna Ala-Kopsala; Olli Vuolteenaho; Heikki Ruskoaho; Kristiina Nyyssönen; Jukka T Salonen
Plasma N-terminal fragments of natriuretic propeptides predict the risk of cardiovascular events and mortality in middle-aged men.
European heart journal 2006;27(10):1230-7.
2006: Tanja Rauma-Pinola; Paavo Pääkkö; Mika Ilves; Raisa Serpi; Hannu Romppanen; Olli Vuolteenaho; Heikki Ruskoaho; Timo Hautala
Adrenomedullin gene transfer induces neointimal apoptosis and inhibits neointimal hyperplasia in injured rat artery.
The journal of gene medicine 2006;8(4):452-8.
2006: Jaana Rysä; Jani Aro; Heikki Ruskoaho
Early left ventricular gene expression profile in response to increase in blood pressure.
Blood pressure 2006;15(6):375-83.
2005: Olli Tenhunen; István Szokodi; Heikki Ruskoaho
Posttranscriptional activation of BNP gene expression in response to increased left ventricular wall stress: role of calcineurin and PKC.
Regulatory peptides 2005;128(3):187-96.
2005: Jaana Rysä; Hanna Leskinen; Mika Ilves; Heikki Ruskoaho
Distinct upregulation of extracellular matrix genes in transition from hypertrophy to hypertensive heart failure.
Hypertension 2005;45(5):927-33.
2005: Minna Ala-Kopsala; Heikki Ruskoaho; Juhani Leppäluoto; Leila Seres; Reka Skoumal; Miklós Tóth; Ferenc Horkay; Olli Vuolteenaho
Single assay for amino-terminal fragments of cardiac A- and B-type natriuretic peptides.
Clinical chemistry 2005;51(4):708-18.
2005: Olli Vuolteenaho; Minna Ala-Kopsala; Heikki Ruskoaho
BNP as a biomarker in heart disease.
Advances in clinical chemistry 2005;40():1-36.
2004: Réka Skoumal; Leila Seres; Pál Soós; Eva Balogh; Tìmea Kovàts; Jaana Rysa; Heikki Ruskoaho; Miklós Tóth; Ferenc Horkay
Endothelin levels in experimental diabetes combined with cardiac hypertrophy.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S195-7.
2004: Paavo Uusimaa; Heikki Tokola; Antti Ylitalo; Olli Vuolteenaho; Heikki Ruskoaho; Juha Risteli; Markku Linnaluoto; Keijo Peuhkurinen
Plasma B-type natriuretic peptide reflects left ventricular hypertrophy and diastolic function in hypertension.
International journal of cardiology 2004;97(2):251-6.
2004: Chris J Pemberton; Heikki Tokola; Zsolt Bagi; Ákos Koller; Juhani Pöntinen; Antti Ola; Olli Vuolteenaho; István Szokodi; Heikki Ruskoaho
Ghrelin induces vasoconstriction in the rat coronary vasculature without altering cardiac peptide secretion.
American journal of physiology. Heart and circulatory physiology 2004;287(4):H1522-9.
2004: Minna Ala-Kopsala; Jarkko Magga; Keijo Peuhkurinen; Jaana A Leipälä; Heikki Ruskoaho; Juhani Leppäluoto; Olli Vuolteenaho
Molecular heterogeneity has a major impact on the measurement of circulating N-terminal fragments of A- and B-type natriuretic peptides.
Clinical chemistry 2004;50(9):1576-88.
2004: Sampsa Pikkarainen; Heikki Tokola; Risto Kerkelä; Heikki Ruskoaho
GATA transcription factors in the developing and adult heart.
Cardiovascular research 2004;63(2):196-207.
2004: Olli Tenhunen; Balázs Sármán; Risto Kerkelä; István Szokodi; Lajos Papp; Miklós Tóth; Heikki Ruskoaho
Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart.
The Journal of biological chemistry 2004;279(23):24852-60.
2004: Eva Ruzicska; Gábor Földes; Zoltan Lako-Futo; Balazs Sarman; Janos Wellmann; Gabor Szenasi; Zsolt Tulassay; Heikki Ruskoaho; Miklos Toth; Anikó Somogyi
Cardiac gene expression of natriuretic substances is altered in streptozotocin-induced diabetes during angiotensin II-induced pressure overload.
Journal of hypertension 2004;22(6):1191-200.
2004: Marja Luodonpää; Hanna Leskinen; Mika Ilves; Olli Vuolteenaho; Heikki Ruskoaho
Adrenomedullin modulates hemodynamic and cardiac effects of angiotensin II in conscious rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;286(6):R1085-92.
2004: Jarkko Magga; Mikko Puhakka; Seppo Hietakorpi; Kari Punnonen; Paavo Uusimaa; Juha Risteli; Olli Vuolteenaho; Heikki Ruskoaho; Keijo Peuhkurinen
Atrial natriuretic peptide, B-type natriuretic peptide, and serum collagen markers after acute myocardial infarction.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(4):1306-11.
2004: Anna H Karjalainen; Heikki Ruskoaho; Olli Vuolteenaho; Jorma Heikkinen; Ann-Christine Bäckström; Markku Savolainen; Y Antero Kesäniemi
Effects of estrogen replacement therapy on natriuretic peptides and blood pressure.
Maturitas 2004;47(3):201-8.
2004: Pasi Tavi; Sampsa Pikkarainen; Jarkko Ronkainen; Perttu Niemelä; Mika Ilves; Matti Weckstrom; Olli Vuolteenaho; Joseph D Bruton; Håkan Westerblad; Heikki Ruskoaho
Pacing-induced calcineurin activation controls cardiac Ca2+ signalling and gene expression.
The Journal of physiology 2004;554(Pt 2):309-20.
2003: Zoltán Lakó-Futó; István Szokodi; Balázs Sármán; Gábor Földes; Heikki Tokola; Mika Ilves; Hanna Leskinen; Olli Vuolteenaho; Réka Skoumal; Rudolf de Châtel; Heikki Ruskoaho; Miklós Tóth
Evidence for a functional role of angiotensin II type 2 receptor in the cardiac hypertrophic process in vivo in the rat heart.
Circulation 2003;108(19):2414-22.
2003: Naotaka Shiota; Jaana Rysä; Petri T Kovanen; Heikki Ruskoaho; Jorma O Kokkonen; Ken A Lindstedt
A role for cardiac mast cells in the pathogenesis of hypertensive heart disease.
Journal of hypertension 2003;21(10):1935-44.
2003: Antti Kuoppala; Naotaka Shiota; Ken A Lindstedt; Jaana Rysä; Hanna Leskinen; Marja Luodonpää; inka liesmaa; Heikki Ruskoaho; Risto Kaaja; Petri T Kovanen; Jorma O Kokkonen
Expression of bradykinin receptors in the left ventricles of rats with pressure overload hypertrophy and heart failure.
Journal of hypertension 2003;21(9):1729-36.
2003: Gábor Földes; Ferenc Horkay; István Szokodi; Olli Vuolteenaho; Mika Ilves; Ken A Lindstedt; Mikko I Mäyränpää; Balázs Sármán; Leila Seres; Réka Skoumal; Zoltán Lakó-Futó; Rudolf de Châtel; Heikki Ruskoaho; Miklós Tóth
Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure.
Biochemical and biophysical research communications 2003;308(3):480-5.
2003: Jarkko Piuhola; Markus Makinen; István Szokodi; Heikki Ruskoaho
Dual role of endothelin-1 via ETA and ETB receptors in regulation of cardiac contractile function in mice.
American journal of physiology. Heart and circulatory physiology 2003;285(1):H112-8.
2003: Sampsa Pikkarainen; Heikki Tokola; Theresa Majalahti-Palviainen; Risto Kerkela; Nina Hautala; Suparna S Bhalla; Frédéric Charron; Mona Nemer; Olli Vuolteenaho; Heikki Ruskoaho
GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program.
The Journal of biological chemistry 2003;278(26):23807-16.
2003: István Szokodi; Jarkko Piuhola; Heikki Ruskoaho
Endothelin receptor blockade and exacerbation of heart failure.
Circulation 2003;107(22):e211.
2003: Heikki Ruskoaho
Cardiac hormones as diagnostic tools in heart failure.
Endocrine reviews 2003;24(3):341-56.
2003: Peeter Kööbi; Jarkko Kalliovalkama; Pasi Jolma; Jaana Rysä; Heikki Ruskoaho; Olli Vuolteenaho; Mika Kähönen; Ilkka Tikkanen; Meng Fan; Pauli Ylitalo; Ilkka Pörsti
AT1 receptor blockade improves vasorelaxation in experimental renal failure.
Hypertension 2003;41(6):1364-71.
2003: Marja Luodonpää; Jaana Rysä; Sampsa Pikkarainen; Olli Tenhunen; Heikki Tokola; Jutta Puhakka; Minna Marttila; Olli Vuolteenaho; Heikki Ruskoaho
Mechanisms regulating adrenomedullin gene expression in the left ventricle: role of mechanical load.
Regulatory peptides 2003;112(1-3):153-9.
2003: Olli Vuolteenaho; Heikki Ruskoaho
Gender matters: estrogen protects from cardiac hypertrophy.
Trends in endocrinology and metabolism: TEM 2003;14(2):52-4.
2003: Sampsa Pikkarainen; Heikki Tokola; Risto Kerkelä; Theresa Majalahti-Palviainen; Olli Vuolteenaho; Heikki Ruskoaho
Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors.
The Journal of biological chemistry 2003;278(6):3969-75.
2003: Jarkko Piuhola; István Szokodi; Pietari Kinnunen; Mika Ilves; Rudolf de Châtel; Olli Vuolteenaho; Heikki Ruskoaho
Endothelin-1 contributes to the Frank-Starling response in hypertrophic rat hearts.
Hypertension 2003;41(1):93-8.
2002: Risto Kerkelä; Mika Ilves; Sampsa Pikkarainen; Heikki Tokola; Jarkko Ronkainen; Olli Vuolteenaho; Juhani Leppäluoto; Heikki Ruskoaho
Identification of PKCalpha isoform-specific effects in cardiac myocytes using antisense phosphorothioate oligonucleotides.
Molecular pharmacology 2002;62(6):1482-91.
2002: Pál Soós; Alexander Juhász-Nagy; Heikki Ruskoaho; István Hartyánszky; Béla Merkely; Miklós Tóth; Ferenc Horkay
Locally different role of atrial natriuretic peptide (ANP) in the pericardial fluid.
Life sciences 2002;71(21):2563-73.
2002: István Szokodi; Pasi Tavi; Gábor Földes; Sari Voutilainen-Myllylä; Mika Ilves; Heikki Tokola; Sampsa Pikkarainen; Jarkko Piuhola; Jaana Rysä; Miklós Tóth; Heikki Ruskoaho
Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility.
Circulation research 2002;91(5):434-40.
2002: Maria Suo; Jarkko Kalliovalkama; Ilkka Pörsti; Pasi Jolma; Jari-Petteri Tolvanen; Olli Vuolteenaho; Heikki Ruskoaho
N(G)-nitro-L-arginine methyl ester-induced hypertension and natriuretic peptide gene expression: inhibition by angiotensin II type 1 receptor antagonism.
Journal of cardiovascular pharmacology 2002;40(3):478-86.
2002: Virpi Tervonen; Heikki Ruskoaho; Tiina Lecklin; Mika Ilves; Olli Vuolteenaho
Salmon cardiac natriuretic peptide is a volume-regulating hormone.
American journal of physiology. Endocrinology and metabolism 2002;283(2):E353-61.
2002: Ilkka Pörsti; Mika Kähönen; Xiumin Wu; Pertti Arvola; Heikki Ruskoaho
Long-term physical exercise and atrial natriuretic peptide in obese Zucker rats.
Pharmacology & toxicology 2002;91(1):8-12.
2002: Risto Kerkelä; Sampsa Pikkarainen; Theresa Majalahti-Palviainen; Heikki Tokola; Heikki Ruskoaho
Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene.
The Journal of biological chemistry 2002;277(16):13752-60.
2002: Heidi Vierimaa; Minna Hirvinen; Virpi Tervonen; Olli Arjamaa; Heikki Ruskoaho; Olli Vuolteenaho
Pronatriuretic peptide is a sensitive marker of the endocrine function of teleost heart.
American journal of physiology. Endocrinology and metabolism 2002;282(4):E843-50.
2002: Maria Suo; Nina Hautala; Gábor Földes; István Szokodi; Miklós Tóth; Hanna Leskinen; Paavo Uusimaa; Olli Vuolteenaho; Mona Nemer; Heikki Ruskoaho
Posttranscriptional control of BNP gene expression in angiotensin II-induced hypertension.
Hypertension 2002;39(3):803-8.
2002: Sampsa Pikkarainen; Risto Kerkelä; Juhani Pöntinen; Theresa Majalahti-Palviainen; Heikki Tokola; Sinikka Eskelinen; Olli Vuolteenaho; Heikki Ruskoaho
Decoy oligonucleotide characterization of GATA-4 transcription factor in hypertrophic agonist induced responses of cardiac myocytes.
Journal of molecular medicine (Berlin, Germany) 2002;80(1):51-60.
2002: Nina Hautala; Olli Tenhunen; István Szokodi; Heikki Ruskoaho
Direct left ventricular wall stretch activates GATA4 binding in perfused rat heart: involvement of autocrine/paracrine pathways.
Pflügers Archiv : European journal of physiology 2002;443(3):362-9.
2001: Marja Luodonpää; Olli Vuolteenaho; Sinikka Eskelinen; Heikki Ruskoaho
Effects of adrenomedullin on hypertrophic responses induced by angiotensin II, endothelin-1 and phenylephrine.
Peptides 2001;22(11):1859-66.
2001: Minna Marttila; Nina Hautala; Pierre Paradis; M Toth; Olli Vuolteenaho; Mona Nemer; Heikki Ruskoaho
GATA4 mediates activation of the B-type natriuretic peptide gene expression in response to hemodynamic stress.
Endocrinology 2001;142(11):4693-700.
2001: Virpi Tervonen; K Kokkonen; Heidi Vierimaa; Heikki Ruskoaho; Olli Vuolteenaho
Temperature has a major influence on cardiac natriuretic peptide in salmon.
The Journal of physiology 2001;536(Pt 1):199-209.
2001: Gábor Földes; Maria Suo; István Szokodi; Zoltán Lakó-Futó; Rudolf de Châtel; Olli Vuolteenaho; P Huttunen; Heikki Ruskoaho; Miklós Tóth
Factors derived from adrenals are required for activation of cardiac gene expression in angiotensin II-induced hypertension.
Endocrinology 2001;142(10):4256-63.
2001: Pietari Kinnunen; Jarkko Piuhola; Heikki Ruskoaho; István Szokodi
AM reverses pressor response to ET-1 independently of NO in rat coronary circulation.
American journal of physiology. Heart and circulatory physiology 2001;281(3):H1178-83.
2001: Jarkko Piuhola; Annette Hammes; Kai Schuh; Ludwig Neyses; Olli Vuolteenaho; Heikki Ruskoaho
Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(3):R699-705.
2001: Paavo Uusimaa; Heikki Tokola; Heikki Ruskoaho; Olli Vuolteenaho; Juha Risteli; Antti Ylitalo; Keijo Peuhkurinen
Vasoactive peptides and procollagen propeptides in patients with hypertension in relation to cardiac hypertrophy and diastolic heart failure: design of the study and patient characteristics.
Journal of human hypertension 2001;15 Suppl 1():S19-22.
2001: Heikki Tokola; Nina Hautala; Minna Marttila; Jarkko Magga; Sampsa Pikkarainen; Risto Kerkelä; Olli Vuolteenaho; Heikki Ruskoaho
Mechanical load-induced alterations in B-type natriuretic peptide gene expression.
Canadian journal of physiology and pharmacology 2001;79(8):646-53.
2001: MB Spalding; Tero I Ala-Kokko; Kai Kiviluoma; Heikki Ruskoaho; Seppo Alahuhta
The haemodynamic effects of losartan after right ventricle infarct in young pigs.
Pharmacology & toxicology 2001;88(6):325-30.
2001: Pasi Tavi; M Laine; Matti Weckstrom; Heikki Ruskoaho
Cardiac mechanotransduction: from sensing to disease and treatment.
Trends in pharmacological sciences 2001;22(5):254-60.
2001: Nina Hautala; Heikki Tokola; Marja Luodonpää; Jutta Puhakka; Hannu Romppanen; Olli Vuolteenaho; Heikki Ruskoaho
Pressure overload increases GATA4 binding activity via endothelin-1.
Circulation 2001;103(5):730-5.
2001: Lauri Eklund; Jarkko Piuhola; Jyrki Komulainen; Raija Sormunen; C Ongvarrasopone; R Fássler; Anu Muona; Mika Ilves; Heikki Ruskoaho; T E S Takala; Taina Pihlajaniemi
Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1194-9.
2001: Lászlo Köhidai; K Tóth; Heikki Ruskoaho; György Csaba
Effect of vasoactive peptides on Tetrahymena. chemotactic properties of endothelins (ET-1, ET-2, ET-3, fragment 11-21 of ET-1 and big endothelin-1): a short-term inducible signalling mechanism of chemotaxis.
Cell biology international 2001;25(11):1173-7.
2000: Pasi Tavi; Matti Weckstrom; Heikki Ruskoaho
cAMP- and cGMP-independent stretch-induced changes in the contraction of rat atrium.
Pflügers Archiv : European journal of physiology 2000;441(1):65-8.
2000: Pietari Kinnunen; István Szokodi; M G Nicholls; Heikki Ruskoaho
Impact of NO on ET-1- and AM-induced inotropic responses: potentiation by combined administration.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(2):R569-75.
2000: Virpi Tervonen; Heikki Ruskoaho; Olli Vuolteenaho
Novel cardiac peptide hormone in several teleosts.
The Journal of endocrinology 2000;166(2):407-18.
2000: MB Spalding; Tero I Ala-Kokko; Kai Kiviluoma; Heikki Ruskoaho; Seppo Alahuhta
The effect of aminophylline on right heart function in young pigs after ligation of the right coronary artery.
Pharmacology & toxicology 2000;86(4):192-6.
2000: K Kokkonen; Heidi Vierimaa; S Bergström; Virpi Tervonen; Olli Arjamaa; Heikki Ruskoaho; Matti Järvilehto; Olli Vuolteenaho
Novel salmon cardiac peptide hormone is released from the ventricle by regulated secretory pathway.
American journal of physiology. Endocrinology and metabolism 2000;278(2):E285-92.
2000: Theresa Majalahti-Palviainen; M Hirvinen; Virpi Tervonen; Mika Ilves; Heikki Ruskoaho; Olli Vuolteenaho
Gene structure of a new cardiac peptide hormone: a model for heart-specific gene expression.
Endocrinology 2000;141(2):731-40.
2000: MB Spalding; Tero I Ala-Kokko; Kai Kiviluoma; Heikki Ruskoaho; Seppo Alahuhta
The hemodynamic effects of adenosine infusion after experimental right heart infarct in young swine.
Journal of cardiovascular pharmacology 2000;35(1):93-9.
1999: Jarkko Magga; Jarkko Kalliovalkama; Hannu Romppanen; Olli Vuolteenaho; Ilkka Pörsti; Mika Kähönen; Jari-Petteri Tolvanen; Heikki Ruskoaho
Differential regulation of cardiac adrenomedullin and natriuretic peptide gene expression by AT1 receptor antagonism and ACE inhibition in normotensive and hypertensive rats.
Journal of hypertension 1999;17(11):1543-52.
1999: Panu Taskinen; M Toth; Olli Vuolteenaho; Jarkko Magga; Heikki Ruskoaho
Inhibition of atrial wall stretch-induced cardiac hormone secretion by lavendustin A, a potent tyrosine kinase inhibitor.
Endocrinology 1999;140(9):4198-207.
1999: Kari Ylitalo; Paavo Uusimaa; Olli Vuolteenaho; Heikki Ruskoaho; Keijo Peuhkurinen
Vasoactive peptide release in relation to hemodynamic and metabolic changes during rapid ventricular pacing.
Pacing and clinical electrophysiology : PACE 1999;22(7):1064-70.
1999: Pasi Tavi; M Laine; S Voutilainen; Petri Lehenkari; Olli Vuolteenaho; Heikki Ruskoaho; Matti Weckstrom
Potentiation of stretch-induced atrial natriuretic peptide secretion by intracellular acidosis.
The American journal of physiology 1999;277(1 Pt 2):H405-12.
1999: Paavo Uusimaa; Heikki Ruskoaho; Olli Vuolteenaho; Matti Niemelä; Jaakko Lumme; Markku Ikäheimo; A Jounela; Keijo Peuhkurinen
Plasma vasoactive peptides after acute myocardial infarction in relation to left ventricular dysfunction.
International journal of cardiology 1999;69(1):5-14.
1999: Minna Marttila; Jutta Puhakka; Marja Luodonpää; Olli Vuolteenaho; U Ganten; Heikki Ruskoaho
Augmentation of BNP gene expression in atria by pressure overload in transgenic rats harbouring human renin and angiotensinogen genes.
Blood pressure 1999;8(5-6):308-16.
1999: Paavo Uusimaa; Kerttu Huttunen; Heikki Ruskoaho; Markku Linnaluoto; Markku Ikäheimo
Neurohumoral responses to a single haemodialysis in chronic renal patients.
Acta physiologica Scandinavica 1999;165(1):25-31.
1998: Xiumin Wu; Jari-Petteri Tolvanen; Nina Hutri-Kähönen; Mika Kähönen; H Mäkynen; Riitta Korpela; Heikki Ruskoaho; Kirsi Karjala; Ilkka Pörsti
Comparison of the effects of supplementation with whey mineral and potassium on arterial tone in experimental hypertension.
Cardiovascular research 1998;40(2):364-74.
1998: Virpi Tervonen; Olli Arjamaa; K Kokkonen; Heikki Ruskoaho; Olli Vuolteenaho
A novel cardiac hormone related to A-, B- and C-type natriuretic peptides.
Endocrinology 1998;139(9):4021-5.
1998: Jarkko Magga; Olli Vuolteenaho; Heikki Tokola; Minna Marttila; Heikki Ruskoaho
B-type natriuretic peptide: a myocyte-specific marker for characterizing load-induced alterations in cardiac gene expression.
Annals of medicine 1998;30 Suppl 1():39-45.
1998: István Szokodi; Ferenc Horkay; Béla Merkely; F Solti; László Gellér; P Kiss; László Selmeci; Violetta Kékesi; Olli Vuolteenaho; Heikki Ruskoaho; Alexander Juhász-Nagy; Miklós Tóth
Intrapericardial infusion of endothelin-1 induces ventricular arrhythmias in dogs.
Cardiovascular research 1998;38(2):356-64.
1998: Jari-Petteri Tolvanen; H Mäkynen; Xiumin Wu; Nina Hutri-Kähönen; Heikki Ruskoaho; Kirsi Karjala; Ilkka Pörsti
Effects of calcium and potassium supplements on arterial tone in vitro in spontaneously hypertensive rats.
British journal of pharmacology 1998;124(1):119-28.
1998: István Szokodi; Pietari Kinnunen; Pasi Tavi; Matti Weckstrom; Miklós Tóth; Heikki Ruskoaho
Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide.
Circulation 1998;97(11):1062-70.
1998: Jarkko Magga; Markus Makinen; Hannu Romppanen; Olli Vuolteenaho; Heikki Tokola; Minna Marttila; Heikki Ruskoaho
Coronary pressure as a determinant of B-type natriuretic peptide gene expression in isolated perfused adult rat heart.
Life sciences 1998;63(12):1005-15.
1998: István Szokodi; Ferenc Horkay; P Kiss; László Selmeci; I Horváth; Olli Vuolteenaho; Heikki Ruskoaho; Alexander Juhász-Nagy; Miklós Tóth
Characterization of canine pericardial fluid endothelin-1 levels.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S399-400.
1998: Ferenc Horkay; István Szokodi; László Selmeci; Béla Merkely; Violetta Kékesi; T Vecsey; Olli Vuolteenaho; Heikki Ruskoaho; Alexander Juhász-Nagy; Miklós Tóth
Presence of immunoreactive endothelin-1 and atrial natriuretic peptide in human pericardial fluid.
Life sciences 1998;62(3):267-74.
1997: Jarkko Magga; Olli Vuolteenaho; Minna Marttila; Heikki Ruskoaho
Endothelin-1 is involved in stretch-induced early activation of B-type natriuretic peptide gene expression in atrial but not in ventricular myocytes: acute effects of mixed ET(A)/ET(B) and AT1 receptor antagonists in vivo and in vitro.
Circulation 1997;96(9):3053-62.
1997: Heikki Ruskoaho; Hanna Leskinen; Jarkko Magga; Panu Taskinen; Pentti Mäntymaa; Olli Vuolteenaho; Juhani Leppäluoto
Mechanisms of mechanical load-induced atrial natriuretic peptide secretion: role of endothelin, nitric oxide, and angiotensin II.
Journal of molecular medicine (Berlin, Germany) 1997;75(11-12):876-85.
1997: Jarkko Magga; Olli Vuolteenaho; Heikki Tokola; Minna Marttila; Heikki Ruskoaho
Involvement of transcriptional and posttranscriptional mechanisms in cardiac overload-induced increase of B-type natriuretic peptide gene expression.
Circulation research 1997;81(5):694-702.
1997: M Perhonen; W Wang; X Han; Heikki Ruskoaho; T E S Takala
Right ventricular collagen type III and IV gene expression increases during early phases of endurance training in hypobaric hypoxic condition.
Basic research in cardiology 1997;92(5):299-309.
1997: M Perhonen; T E S Takala; Olli Vuolteenaho; Pentti Mäntymaa; Juhani Leppäluoto; Heikki Ruskoaho
Induction of cardiac natriuretic peptide gene expression in rats trained in hypobaric hypoxic conditions.
The American journal of physiology 1997;273(1 Pt 2):R344-52.
1997: Hannu Romppanen; Minna Marttila; Jarkko Magga; Olli Vuolteenaho; Pietari Kinnunen; István Szokodi; Heikki Ruskoaho
Adrenomedullin gene expression in the rat heart is stimulated by acute pressure overload: blunted effect in experimental hypertension.
Endocrinology 1997;138(6):2636-9.
1997: Hanna Leskinen; Olli Vuolteenaho; M Toth; Heikki Ruskoaho
Atrial natriuretic peptide (ANP) inhibits its own secretion via ANP(A) receptors: altered effect in experimental hypertension.
Endocrinology 1997;138(5):1893-902.
1997: István Szokodi; Ferenc Horkay; P Kiss; László Selmeci; Béla Merkely; Violetta Kékesi; Olli Vuolteenaho; Juhani Leppäluoto; Heikki Ruskoaho; Alexander Juhász-Nagy; Miklós Tóth
Characterization and stimuli for production of pericardial fluid atrial natriuretic peptide in dogs.
Life sciences 1997;61(14):1349-59.
1997: Hanna Leskinen; Olli Vuolteenaho; Heikki Ruskoaho
Combined inhibition of endothelin and angiotensin II receptors blocks volume load-induced cardiac hormone release.
Circulation research 1997;80(1):114-23.
1996: Minna Marttila; Olli Vuolteenaho; D Ganten; K Nakao; Heikki Ruskoaho
Synthesis and secretion of natriuretic peptides in the hypertensive TGR(mREN-2)27 transgenic rat.
Hypertension 1996;28(6):995-1004.
1996: Miklós Tóth; Panu Taskinen; Heikki Ruskoaho
Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart.
The Journal of endocrinology 1996;150(3):487-95.
1996: Kari Ylitalo; J Airaksinen; Markku Ikäheimo; Heikki Ruskoaho; Keijo Peuhkurinen
No evidence for ischemic preconditioning during repeated vessel occlusion in coronary angioplasty.
International journal of cardiology 1996;55(3):227-37.
1996: Panu Taskinen; Heikki Ruskoaho
Stretch-induced increase in atrial natriuretic peptide secretion is blocked by thapsigargin.
European journal of pharmacology 1996;308(3):295-300.
1996: M Pelkonen; M Luodonpää; Olli Vuolteenaho; Markku Pasanen; Heikki Ruskoaho
Cocaine increases circulating levels of atrial natriuretic peptide and pro atrial natriuretic peptide N-terminal fragment in conscious rats.
European journal of pharmacology 1996;304(1-3):55-62.
1996: K Sallinen; Pertti Arvola; H Wuorela; Heikki Ruskoaho; Heikki Vapaatalo; Ilkka Pörsti
High calcium diet reduces blood pressure in exercised and nonexercised hypertensive rats.
American journal of hypertension 1996;9(2):144-56.
1996: István Szokodi; Pietari Kinnunen; Heikki Ruskoaho
Inotropic effect of adrenomedullin in the isolated perfused rat heart.
Acta physiologica Scandinavica 1996;156(2):151-2.
1995: R Klemola; M Laine; Matti Weckstrom; Olli Vuolteenaho; Heikki Ruskoaho; Pirkko Huttunen; Juhani Leppäluoto
High concentrations of atrial natriuretic peptide and brain natriuretic peptide in rat pericardial fluid and their reduction by reserpine in vivo.
Naunyn-Schmiedeberg's archives of pharmacology 1995;352(3):331-6.
1995: Hanna Leskinen; Olli Vuolteenaho; Juhani Leppäluoto; Heikki Ruskoaho
Role of nitric oxide on cardiac hormone secretion: effect of NG-nitro-L-arginine methyl ester on atrial natriuretic peptide and brain natriuretic peptide release.
Endocrinology 1995;136(3):1241-9.
1995: Ferenc Horkay; M Laine; István Szokodi; J Leppäluoto; Olli Vuolteenaho; Heikki Ruskoaho; Alexander Juhász-Nagy; Miklós Tóth
Human pericardial fluid contains the highest amount of endothelin-1 of all mammalian biologic fluids thus far tested.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S502-4.
1995: Keijo Peuhkurinen; Paavo Uusimaa; Heikki Ruskoaho; Markku Linnaluoto; H Huikuri
Hemodynamic recovery, atrial natriuretic peptide, and catecholamines during simulated ventricular tachycardia: effects of ventriculoatrial conduction.
Pacing and clinical electrophysiology : PACE 1995;18(1 Pt 1):75-82.
1994: M Laine; Olli Arjamaa; Olli Vuolteenaho; Heikki Ruskoaho; Matti Weckstrom
Block of stretch-activated atrial natriuretic peptide secretion by gadolinium in isolated rat atrium.
The Journal of physiology 1994;480 ( Pt 3)():553-61.
1994: Jarkko Magga; Minna Marttila; Pentti Mäntymaa; Olli Vuolteenaho; Heikki Ruskoaho
Brain natriuretic peptide in plasma, atria, and ventricles of vasopressin- and phenylephrine-infused conscious rats.
Endocrinology 1994;134(6):2505-15.
1994: Hanna Leskinen; Heikki Ruskoaho; P Huttunen; Juhani Leppäluoto; Olli Vuolteenaho
Hemorrhage effects on plasma ANP, NH2-terminal pro-ANP, and pressor hormones in anesthetized and conscious rats.
The American journal of physiology 1994;266(6 Pt 2):R1933-43.
1994: Panu Taskinen; M Tóth; Heikki Ruskoaho
Effects of genistein on cardiac contractile force and atrial natriuretic peptide secretion in the isolated perfused rat heart.
European journal of pharmacology 1994;256(3):251-61.
1994: Heikki Tokola; K Salo; Olli Vuolteenaho; Heikki Ruskoaho
Basal and acidic fibroblast growth factor-induced atrial natriuretic peptide gene expression and secretion is inhibited by staurosporine.
European journal of pharmacology 1994;267(2):195-206.
1994: M Tóth; KH Vuorinen; Olli Vuolteenaho; Ilmo E Hassinen; Paavo Uusimaa; Juhani Leppäluoto; Heikki Ruskoaho
Hypoxia stimulates release of ANP and BNP from perfused rat ventricular myocardium.
The American journal of physiology 1994;266(4 Pt 2):H1572-80.
1994: Pentti Mäntymaa; Jari P A Arokoski; Ilkka Pörsti; M Perhonen; Pertti Arvola; Heikki J Helminen; T E S Takala; Juhani Leppäluoto; Heikki Ruskoaho
Effect of endurance training on atrial natriuretic peptide gene expression in normal and hypertrophied hearts.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(3):1184-94.
1993: Paavo Uusimaa; Kai Kiviluoma; M Tóth; Ilmo E Hassinen; Keijo Peuhkurinen; Heikki Ruskoaho
Adenosine inhibits the release of atrial natriuretic peptide from the perfused rat heart.
European journal of pharmacology 1993;242(2):199-203.
1993: Pentti Mäntymaa; Olli Vuolteenaho; Minna Marttila; Heikki Ruskoaho
Atrial stretch induces rapid increase in brain natriuretic peptide but not in atrial natriuretic peptide gene expression in vitro.
Endocrinology 1993;133(3):1470-3.
1993: Paavo Uusimaa; Markku Ikäheimo; Heikki Ruskoaho; K E Juhani Airaksinen; Heikki V Huikuri; Markku Linnaluoto; J T Takkunen; Keijo Peuhkurinen
Release of atrial natriuretic peptide in relation to metabolic changes during myocardial ischaemia induced by coronary angioplasty.
European heart journal 1993;14(5):682-6.
1993: Pietari Kinnunen; Olli Vuolteenaho; Heikki Ruskoaho
Mechanisms of atrial and brain natriuretic peptide release from rat ventricular myocardium: effect of stretching.
Endocrinology 1993;132(5):1961-70.
1993: Pertti Arvola; Heikki Ruskoaho; H Wuorela; A Pekki; Heikki Vapaatalo; Ilkka Pörsti
Quinapril treatment and arterial smooth muscle responses in spontaneously hypertensive rats.
British journal of pharmacology 1993;108(4):980-90.
1993: Pertti Arvola; Heikki Ruskoaho; Ilkka Pörsti
Effects of high calcium diet on arterial smooth muscle function and electrolyte balance in mineralocorticoid-salt hypertensive rats.
British journal of pharmacology 1993;108(4):948-58.
1992: Pietari Kinnunen; Olli Vuolteenaho; Paavo Uusimaa; Heikki Ruskoaho
Passive mechanical stretch releases atrial natriuretic peptide from rat ventricular myocardium.
Circulation research 1992;70(6):1244-53.
1992: Juhani Leppäluoto; Heikki Ruskoaho
Endothelin peptides: biological activities, cellular signalling and clinical significance.
Annals of medicine 1992;24(3):153-61.
1992: Paavo Uusimaa; Ilmo E Hassinen; Olli Vuolteenaho; Heikki Ruskoaho
Endothelin-induced atrial natriuretic peptide release from cultured neonatal cardiac myocytes: the role of extracellular calcium and protein kinase-C.
Endocrinology 1992;130(5):2455-64.
1992: Paavo Uusimaa; Keijo Peuhkurinen; Olli Vuolteenaho; Heikki Ruskoaho; Ilmo E Hassinen
Role of myocardial redox and energy states in ischemia-stimulated release of atrial natriuretic peptide.
Journal of molecular and cellular cardiology 1992;24(2):191-205.
1992: Juhani Leppäluoto; Olli Vuolteenaho; Olli Arjamaa; Heikki Ruskoaho
Plasma immunoreactive atrial natriuretic peptide and vasopressin after ethanol intake in man.
Acta physiologica Scandinavica 1992;144(2):121-7.
1992: P Kukkonen; Olli Vuolteenaho; Heikki Ruskoaho
Basal and volume expansion-stimulated plasma atrial natriuretic peptide concentrations and hemodynamics in conscious rats: effects of SCH 39.370, an endopeptidase inhibitor, and C-ANF-(4-23), a clearance receptor ligand.
Endocrinology 1992;130(2):755-65.
1992: Paavo Uusimaa; Keijo Peuhkurinen; Ilmo E Hassinen; Olli Vuolteenaho; Heikki Ruskoaho
Ischemia stimulates the release of atrial natriuretic peptide from rat cardiac ventricular myocardium in vitro.
Life sciences 1992;50(5):365-73.
1991: Heikki Ruskoaho; Pietari Kinnunen; Pentti Mäntymaa; Paavo Uusimaa; T Taskinen; Olli Vuolteenaho; Juhani Leppäluoto
Cellular signals regulating the release of ANF.
Canadian journal of physiology and pharmacology 1991;69(10):1514-24.
1991: Heikki Tokola; Paavo Uusimaa; T Taskinen; Ilmo E Hassinen; Heikki Ruskoaho
Effect of hypo-osmolality on atrial natriuretic peptide gene expression in neonatal cultured cardiomyocytes.
Acta physiologica Scandinavica 1991;143(2):223-4.
1991: Juhani Leppäluoto; Olli Arjamaa; Olli Vuolteenaho; Heikki Ruskoaho
Passive heat exposure leads to delayed increase in plasma levels of atrial natriuretic peptide in humans.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(2):716-20.
1991: M Pitkänen; Pentti Mäntymaa; Heikki Ruskoaho
Staurosporine, a protein kinase C inhibitor, inhibits atrial natriuretic peptide secretion induced by sarafotoxin, endothelin and phorbol ester.
European journal of pharmacology 1991;195(3):307-15.
1991: T E S Takala; Heikki Kainulainen; Jyrki Komulainen; Heikki Ruskoaho
Coronary pressure determines regional glucose uptake in the left ventricular wall of the heart.
Journal of molecular and cellular cardiology 1991;23(3):381-5.
1991: Pietari Kinnunen; T Taskinen; M Järvinen; Heikki Ruskoaho
Effect of phorbol ester on the release of atrial natriuretic peptide from the hypertrophied rat myocardium.
British journal of pharmacology 1991;102(2):453-61.
1990: Heikki Ruskoaho; Olli Vuolteenaho; Juhani Leppäluoto
Phorbol esters enhance stretch-induced atrial natriuretic peptide secretion.
Endocrinology 1990;127(5):2445-55.
1990: Paavo Uusimaa; Heikki Ruskoaho; Juhani Leppäluoto; Ilmo E Hassinen
Cytosolic Ca2+ during atrial natriuretic peptide secretion from cultured neonatal cardiomyocytes.
Molecular and cellular endocrinology 1990;73(2-3):153-63.
1990: A Pesonen; Juhani Leppäluoto; Heikki Ruskoaho
Mechanism of opioid-induced atrial natriuretic peptide release in conscious rats.
The Journal of pharmacology and experimental therapeutics 1990;254(2):690-5.
1990: Juhani Leppäluoto; Heikki Ruskoaho
Atrial natriuretic peptide, renin activity, aldosterone, urine volume and electrolytes during a 24-h sleep-wake cycle in man.
Acta physiologica Scandinavica 1990;139(1):47-53.
1990: Pietari Kinnunen; T Taskinen; Juhani Leppäluoto; Heikki Ruskoaho
Release of atrial natriuretic peptide from rat myocardium in vitro: effect of minoxidil-induced hypertrophy.
British journal of pharmacology 1990;99(4):701-8.
1990: Pentti Mäntymaa; Juhani Leppäluoto; Heikki Ruskoaho
Endothelin stimulates basal and stretch-induced atrial natriuretic peptide secretion from the perfused rat heart.
Endocrinology 1990;126(1):587-95.
1989: Heikki Kainulainen; P Virtanen; Heikki Ruskoaho; T E S Takala
Training increases cardiac glucose uptake during rest and exercise in rats.
The American journal of physiology 1989;257(3 Pt 2):H839-45.
1989: M Lilja; Markku Ikäheimo; H Juustila; H Pirttiaho; A Pakarinen; J Leppäluoto; A J Jounela; Heikki Ruskoaho
Abrupt change from a beta-adrenoceptor blocking drug to enalapril in hypertension.
Journal of internal medicine 1989;226(3):143-8.
1989: Heikki Ruskoaho; Pietari Kinnunen; T Taskinen; Olli Vuolteenaho; Juhani Leppäluoto; T E S Takala
Regulation of ventricular atrial natriuretic peptide release in hypertrophied rat myocardium. Effects of exercise.
Circulation 1989;80(2):390-400.
1989: Heikki Ruskoaho; Juhani Leppäluoto
The effect of medetomidine, an alpha 2-adrenoceptor agonist, on plasma atrial natriuretic peptide levels, haemodynamics and renal excretory function in spontaneously hypertensive and Wistar-Kyoto rats.
British journal of pharmacology 1989;97(1):125-32.
1989: Heikki Ruskoaho; T Taskinen; A Pesonen; Olli Vuolteenaho; Juhani Leppäluoto; L Tuomisto
Atrial natriuretic peptide in plasma, atria, ventricles, and hypothalamus of Long-Evans and vasopressin-deficient Brattleboro rats.
Endocrinology 1989;124(5):2595-603.
1989: J A Leipälä; P Virtanen; Heikki Ruskoaho; Ilmo E Hassinen; T E S Takala
Transmural distribution of left ventricular glucose uptake in spontaneously hypertensive rats during rest and exercise.
Acta physiologica Scandinavica 1989;135(4):435-42.
1989: Markku Ikäheimo; Heikki Ruskoaho; K E Juhani Airaksinen; Heikki V Huikuri; U R Korhonen; P J Leppäluoto; M O Tuominen; J T Takkunen
Plasma levels of atrial natriuretic peptide during myocardial ischemia induced by percutaneous transluminal coronary angioplasty or dynamic exercise.
American heart journal 1989;117(4):837-41.
1989: Heikki Ruskoaho; O Vakkuri; Olli Arjamaa; Olli Vuolteenaho; Juhani Leppäluoto
Pressor hormones regulate atrial-stretch-induced release of atrial natriuretic peptide in the pithed rat.
Circulation research 1989;64(3):482-92.
1988: J A Leipälä; T E S Takala; Heikki Ruskoaho; Raili Myllylä; Heikki Kainulainen; Ilmo E Hassinen; H Anttinen; Veikko Vihko
Transmural distribution of biochemical markers of total protein and collagen synthesis, myocardial contraction speed and capillary density in the rat left ventricle in angiotensin II-induced hypertension.
Acta physiologica Scandinavica 1988;133(3):325-33.
1988: Olli Vuolteenaho; Olli Arjamaa; O Vakkuri; T Maksniemi; L Nikkilä; J Kangas; J Puurunen; Heikki Ruskoaho; Juhani Leppäluoto
Atrial natriuretic peptide (ANP) in rat gastrointestinal tract.
FEBS letters 1988;233(1):79-82.
1988: Heikki Ruskoaho
Effect of atenolol and pindolol on the phorbol ester-induced coronary vasoconstriction in the isolated perfused heart of the rat.
British journal of pharmacology 1988;94(2):573-83.
1988: Heikki Ruskoaho; J Leppäluoto
Adrenergic effect on the atrial natriuretic peptide secretion and vasoconstriction induced in the perfused rat heart by phorbol ester.
European journal of pharmacology 1988;148(3):317-25.
1988: Heikki Ruskoaho; Juhani Leppäluoto
Immunoreactive atrial natriuretic peptide in ventricles, atria, hypothalamus, and plasma of genetically hypertensive rats.
Circulation research 1988;62(2):384-94.
1988: Olli Arjamaa; Heikki Ruskoaho; M Tuominen; O Vakkuri; Juhani Leppäluoto
The concentration of atrial natriuretic peptide (ANP) is decreased in plasma but not in atria in hypophysectomised rats.
Life sciences 1988;42(5):589-96.
1988: Juha-Matti Savola; Heikki Ruskoaho; J S Salonen; J Puurunen; A Karjalainen; K Kurkela; N T Kärki
Cardiovascular and sedative alpha-adrenoceptor effects of detomidine-like arylalkyl imidazoles and associated derivatives.
Arzneimittel-Forschung 1988;38(1):29-35.
1987: J Puurunen; Heikki Ruskoaho
Vagal-dependent stimulation of gastric acid secretion by intracerebroventricularly administered atrial natriuretic peptide in anaesthetized rats.
European journal of pharmacology 1987;141(3):493-5.
1986: Juha-Matti Savola; Heikki Ruskoaho; J Puurunen; J S Salonen; N T Kärki
Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoreceptors.
Journal of autonomic pharmacology 1986;6(4):275-84.
1986: Juha-Matti Savola; Raine Virtanen; A Karjalainen; Heikki Ruskoaho; J Puurunen; N T Kärki
Re-evaluation of drug-interaction with alpha-adrenoceptors in vivo and in vitro using imidazole derivatives.
Life sciences 1986;38(15):1409-15.
1985: Juha-Matti Savola; Heikki Ruskoaho; J Puurunen; N T Kärki
Cardiovascular action of detomidine, a sedative and analgesic imidazole derivative with alpha-agonistic properties.
European journal of pharmacology 1985;118(1-2):69-76.
1985: Juha-Matti Savola; J Puurunen; Heikki Ruskoaho; N T Kärki
Peripheral cardiovascular alpha- and beta-adrenergic effects of some hypotensive and bradycardic arylalkyl imidazole derivatives in the rat.
The Journal of pharmacy and pharmacology 1985;37(6):410-4.
1985: Raine Virtanen; Heikki Ruskoaho; L Nyman
Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic.
Journal of veterinary pharmacology and therapeutics 1985;8(1):30-7.
1983: Heikki Ruskoaho; Juha-Matti Savola; S Kaipiainen; J Puurunen; N Kärki
The cardiovascular effects of MPV 295 [4(5)-2-(2,6-dimethylphenyl)ethylimidazole], a new antihypertensive agent with alpha 2-adrenoceptor agonistic properties.
Naunyn-Schmiedeberg's archives of pharmacology 1983;322(4):279-85.
1983: J Puurunen; Heikki Ruskoaho; N T Kärki; A Karjalainen; K Kurkela
A comparative study on hypotensive and bradycardic effects of some new imidazole derivatives with possible central mechanism of action.
Archives internationales de pharmacodynamie et de thérapie 1983;261(1):102-8.