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Lany Ruslim

Research Profile

Concepts & Ideas

Chemicals & Drugs

Living Beings

Mouse

Anatomy

Genes & Molecular Sequences

Molecular Structure

Physiology

Cell Membrane Permeability

Occupations

Drug Design

Phenomena

Phosphorylation

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Co-author Network

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Publications

TOP 3
Ying-Zi Xu; Jiangli Yan; Nanhua Yao; Shendong Yuan; Yong L Zhu; Paul Beroza; Michael P Bova; Simeon Bowers; Eric Brecht; Wayman Chan; Roy K Hom; Julie Lougheed; Hu Pan; Zhao Ren; Lany Ruslim; Hing L Sham; Danny Tam; Dean R Artis
Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
Simeon Bowers; Eric Brecht; Wayman Chan; Roy K Hom; Andrei W Konradi; Julie Lougheed; Hu Pan; Gary D Probst; Zhao Ren; Lany Ruslim; Hing L Sham; Danny Tam; Ying-zi Xu; Nanhua Yao; Shendong Yuan; Yong L Zhu; Paul Beroza; Michael P Bova; Dean R Artis
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Albert W Garofalo; Erich Goldbach; Grace T Kwong; Ruth Motter; Gary D Probst; Kevin P Quinn; Marc Adler; Danielle L Aubele; Elizabeth F Brigham; David Chian; Maurizio Franzini; Lany Ruslim; Hing L Sham; Danny Tam; Pearl Tanaka; Anh P Truong; Xiaocong M Ye; Zhao Ren
Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.

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All Publications

2013: Ying-Zi Xu; Jiangli Yan; Nanhua Yao; Shendong Yuan; Yong L Zhu; Paul Beroza; Michael P Bova; Simeon Bowers; Eric Brecht; Wayman Chan; Roy K Hom; Julie Lougheed; Hu Pan; Zhao Ren; Lany Ruslim; Hing L Sham; Danny Tam; Dean R Artis
Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
Bioorganic & medicinal chemistry letters 2013;23(10):3075-80.
2013: Simeon Bowers; Eric Brecht; Wayman Chan; Roy K Hom; Andrei W Konradi; Julie Lougheed; Hu Pan; Gary D Probst; Zhao Ren; Lany Ruslim; Hing L Sham; Danny Tam; Ying-zi Xu; Nanhua Yao; Shendong Yuan; Yong L Zhu; Paul Beroza; Michael P Bova; Dean R Artis
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bioorganic & medicinal chemistry letters 2013;23(7):2181-6.
2013: Albert W Garofalo; Erich Goldbach; Grace T Kwong; Ruth Motter; Gary D Probst; Kevin P Quinn; Marc Adler; Danielle L Aubele; Elizabeth F Brigham; David Chian; Maurizio Franzini; Lany Ruslim; Hing L Sham; Danny Tam; Pearl Tanaka; Anh P Truong; Xiaocong M Ye; Zhao Ren
Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.
Bioorganic & medicinal chemistry letters 2013;23(7):1974-7.
2011: R Jeffrey Neitz; Andrei W Konradi; Hing L Sham; Wes Zmolek; Karina Wong; Ann Qin; Colin Lorentzen; David Nakamura; Kevin P Quinn; John-Michael Sauer; Kyle Powell; Lany Ruslim; David Chereau; Zhao Ren; John Anderson; Frédérique Bard; Ted A Yednock; Irene Griswold-Prenner
Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement.
Bioorganic & medicinal chemistry letters 2011;21(12):3726-9.
2011: Simeon Bowers; Anh P Truong; R Jeffrey Neitz; Martin Neitzel; Gary D Probst; Roy K Hom; Brian Peterson; Robert Anthony Galemmo; Andrei W Konradi; Hing L Sham; Gergley Tóth; Hu Pan; Nanhua Yao; Dean R Artis; Elizabeth F Brigham; Kevin P Quinn; John-Michael Sauer; Kyle Powell; Lany Ruslim; Zhao Ren; Frédérique Bard; Ted Yednock; Irene Griswold-Prenner
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Bioorganic & medicinal chemistry letters 2011;21(6):1838-43.
2011: Gary D Probst; Simeon Bowers; Jennifer M Sealy; Anh P Truong; Roy K Hom; Robert Anthony Galemmo; Andrei W Konradi; Hing L Sham; David A Quincy; Hu Pan; Nanhua Yao; May Lin; Gergley Tóth; Dean R Artis; Wes Zmolek; Karina Wong; Ann Qin; Colin Lorentzen; David F Nakamura; Kevin P Quinn; John-Michael Sauer; Kyle Powell; Lany Ruslim; Sarah Wright; David Chereau; Zhao Ren; John P Anderson; Frédérique Bard; Ted A Yednock; Irene Griswold-Prenner
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Bioorganic & medicinal chemistry letters 2011;21(1):315-9.
2010: Anh P Truong; Gary D Probst; Jose Aquino; Larry Fang; Louis Brogley; Jennifer M Sealy; Roy K Hom; John A Tucker; Varghese John; jay tung; Michael A Pleiss; Andrei W Konradi; Hing L Sham; Michael S Dappen; Gergley Tóth; Nanhua Yao; Eric Brecht; Hu Pan; Dean R Artis; Lany Ruslim; Michael P Bova; Sukanto Sinha; Ted A Yednock; Wes Zmolek; Kevin P Quinn; John-Michael Sauer
Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents.
Bioorganic & medicinal chemistry letters 2010;20(16):4789-94.
2009: Jennifer M Sealy; Anh P Truong; Luke Tso; Gary D Probst; Jose Aquino; Roy K Hom; Barbara M Jagodzinska; Darren Dressen; David W G Wone; Louis Brogley; Varghese John; jay tung; Michael A Pleiss; John A Tucker; Andrei W Konradi; Michael S Dappen; Gergely Toth; Hu Pan; Lany Ruslim; Jim Miller; Michael P Bova; Sukanto Sinha; Kevin P Quinn; John-Michael Sauer
Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents.
Bioorganic & medicinal chemistry letters 2009;19(22):6386-91.
2007: Jon E Hawkinson; Balazs G Szoke; Albert W Garofalo; Dennis S Hom; Hongbing Zhang; Mark Dreyer; Juri Y Fukuda; Linda Chen; Bhushan Samant; Stellanie Simmonds; Karla P Zeitz; Angie Wadsworth; Anna Liao; Raymond A Chavez; Wes Zmolek; Lany Ruslim; Michael P Bova; Ryan Holcomb; Eduardo R Butelman; Mei-Chuan Ko; Annika B Malmberg
Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.
The Journal of pharmacology and experimental therapeutics 2007;322(2):619-30.
2003: James G Christensen; Randall E Schreck; Jon Burrows; Poonam Kuruganti; Emily Chan; Phuong Le; Jeffrey Chen; Xueyan Wang; Lany Ruslim; Robert Blake; Kenneth E Lipson; John Ramphal; Steven Do; Jingrong J Cui; Julie M Cherrington; Dirk B Mendel
A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.
Cancer research 2003;63(21):7345-55.
2003: Deborah J Moshinsky; Lany Ruslim; Robert Blake; Flora Tang
A widely applicable, high-throughput TR-FRET assay for the measurement of kinase autophosphorylation: VEGFR-2 as a prototype.
Journal of biomolecular screening 2003;8(4):447-52.

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