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Michael Russell

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Jason M Elliott; Robert W Carling; Mark Chambers; Gary G Chicchi; Peter H Hutson; A Brian Jones; Angus MacLeod; Rose Marwood; Georgina Meneses-Lorente; Elena Mezzogori; Fraser Murray; Michael Rigby; Inmaculada Royo; Michael G N Russell; Bindi Sohal; Kwei-Lan Tsao; Brian Williams
N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists.
Jason M Elliott; Robert W Carling; Gary G Chicchi; James Crawforth; Peter H Hutson; A Brian Jones; Sarah Kelly; Rose Marwood; Georgina Meneses-Lorente; Elena Mezzogori; Fraser Murray; Michael Rigby; Inmaculada Royo; Michael G N Russell; Duncan Shaw; Bindi Sohal; Kwei-Lan Tsao; Brian Williams
N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II.
Robert W Carling; Michael G N Russell; Kevin W Moore; Andrew Mitchinson; Alec Guiblin; Alison Smith; Keith A Wafford; George Marshall; John R Atack; Leslie J Street
2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: functionally selective GABAA alpha3-subtype agonists.

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All Publications

2006: Jason M Elliott; Robert W Carling; Mark Chambers; Gary G Chicchi; Peter H Hutson; A Brian Jones; Angus MacLeod; Rose Marwood; Georgina Meneses-Lorente; Elena Mezzogori; Fraser Murray; Michael Rigby; Inmaculada Royo; Michael G N Russell; Bindi Sohal; Kwei-Lan Tsao; Brian Williams
N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(22):5748-51.
2006: Jason M Elliott; Robert W Carling; Gary G Chicchi; James Crawforth; Peter H Hutson; A Brian Jones; Sarah Kelly; Rose Marwood; Georgina Meneses-Lorente; Elena Mezzogori; Fraser Murray; Michael Rigby; Inmaculada Royo; Michael G N Russell; Duncan Shaw; Bindi Sohal; Kwei-Lan Tsao; Brian Williams
N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II.
Bioorganic & medicinal chemistry letters 2006;16(22):5752-6.
2006: Robert W Carling; Michael G N Russell; Kevin W Moore; Andrew Mitchinson; Alec Guiblin; Alison Smith; Keith A Wafford; George Marshall; John R Atack; Leslie J Street
2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: functionally selective GABAA alpha3-subtype agonists.
Bioorganic & medicinal chemistry letters 2006;16(13):3550-4.
2006: Andrew S R Jennings; Richard T Lewis; Michael G N Russell; David J Hallett; Leslie J Street; José L Castro; John R Atack; Susan M Cook; Rachael Lincoln; Joanna Stanley; Alison J Smith; David S Reynolds; Bindi Sohal; Andrew Pike; George R Marshall; Keith A Wafford; Wayne F A Sheppard; Spencer J Tye
Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
Bioorganic & medicinal chemistry letters 2006;16(6):1477-80.
2006: Michael G N Russell; Robert W Carling; Leslie J Street; David J Hallett; Simon C Goodacre; Elena Mezzogori; Michael Reader; Susan M Cook; Frances A Bromidge; Robert Newman; Alison J Smith; Keith A Wafford; George R Marshall; David S Reynolds; Rebecca Dias; Pushpinder Ferris; Joanna Stanley; Rachael Lincoln; Spencer J Tye; Wayne F A Sheppard; Bindi Sohal; Andrew Pike; Maria Dominguez; John R Atack; José L Castro
Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.
Journal of medicinal chemistry 2006;49(4):1235-8.
2005: Robert W Carling; Andrew Madin; Alec Guiblin; Michael G N Russell; Kevin W Moore; Andrew Mitchinson; Bindi Sohal; Andrew Pike; Susan M Cook; Ian C Ragan; Ruth M McKernan; Kathleen Quirk; Pushpinder Ferris; George Marshall; Sally-Anne Thompson; Keith A Wafford; Gerard R Dawson; John R Atack; Timothy Harrison; José L Castro; Leslie J Street
7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.
Journal of medicinal chemistry 2005;48(23):7089-92.
2005: Wesley P Blackaby; John R Atack; Frances A Bromidge; Richard Lewis; Michael G N Russell; Alison Smith; Keith A Wafford; Ruth M McKernan; Leslie J Street; José L Castro
Pyrazolopyridinones as functionally selective GABAA ligands.
Bioorganic & medicinal chemistry letters 2005;15(22):4998-5002.
2005: Michael G N Russell; Robert W Carling; John R Atack; Frances A Bromidge; Susan M Cook; Peter Hunt; Catherine Isted; Matt Lucas; Ruth M McKernan; Andrew Mitchinson; Kevin W Moore; Robert Narquizian; Alison Macaulay; David Thomas; Sally-Anne Thompson; Keith A Wafford; José L Castro
Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit.
Journal of medicinal chemistry 2005;48(5):1367-83.
2004: Andrew Mitchinson; John R Atack; Peter Blurton; Robert W Carling; José L Castro; Karen S Curley; Michael G N Russell; George Marshall; Ruth M McKernan; Kevin W Moore; Robert Narquizian; Alison Smith; Leslie J Street; Sally-Anne Thompson; Keith A Wafford
2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor.
Bioorganic & medicinal chemistry letters 2004;14(13):3441-4.
2002: Michael G N Russell; Rebecca Dias
Memories are made of this (perhaps): a review of serotonin 5-HT(6) receptor ligands and their biological functions.
Current topics in medicinal chemistry 2002;2(6):643-54.
2001: Michael G N Russell; R J Baker; L Barden; Margaret S Beer; Linda J Bristow; Howard B Broughton; M Knowles; George McAllister; Smita Patel; José L Castro
N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.
Journal of medicinal chemistry 2001;44(23):3881-95.
2000: Fraser Murray; J Kennedy; Peter H Hutson; J Elliot; Ian T Huscroft; K Mohnen; Michael G N Russell; Sarah Grimwood
Modulation of [3H]MK-801 binding to NMDA receptors in vivo and in vitro.
European journal of pharmacology 2000;397(2-3):263-70.
2000: Susan Boyce; Janine K Webb; Sara Shepheard; Michael G N Russell; Raymond G Hill; Nadia M J Rupniak
Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats.
Pain 2000;85(3):443-50.
1999: Michael G N Russell; VG Matassa; R R Pengilley; Monique B van Niel; Bindi Sohal; Alan P Watt; Laure Hitzel; Margaret S Beer; Josephine A Stanton; Howard B Broughton; José L Castro
3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.
Journal of medicinal chemistry 1999;42(24):4981-5001.
1999: Michael G N Russell; Margaret S Beer; Josephine A Stanton; Bindi Sohal; Russell Mortishire-Smith; José L Castro
2,7-diazabicyclo[3.3.0]octanes as novel h5-HT receptor agonists.
Bioorganic & medicinal chemistry letters 1999;9(17):2491-6.
1999: Monique B van Niel; Ian Collins; Margaret S Beer; Howard B Broughton; Susan K F Cheng; Simon C Goodacre; A Heald; Karen Locker; Angus M MacLeod; Denise Morrison; Christopher Moyes; desmond oconnor; Andrew Pike; Michael Rowley; Michael G N Russell; Bindi Sohal; Josephine A Stanton; Steven Thomas; H Verrier; Alan P Watt; José L Castro
Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.
Journal of medicinal chemistry 1999;42(12):2087-104.
1999: Michael G N Russell
Recent developments in 5-HT(1D) agonists.
IDrugs : the investigational drugs journal 1999;2(1):37-43.
1998: José L Castro; Ian Collins; Michael G N Russell; Alan P Watt; Bindi Sohal; D Rathbone; Margaret S Beer; Josephine A Stanton
Enhancement of oral absorption in selective 5-HT1D receptor agonists: fluorinated 3-[3-(piperidin-1-yl)propyl]indoles.
Journal of medicinal chemistry 1998;41(15):2667-70.
1997: José L Castro; Leslie J Street; Alec Guiblin; Richard A Jelley; Michael G N Russell; Francine Sternfeld; Margaret S Beer; Josephine A Stanton; VG Matassa
3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype.
Journal of medicinal chemistry 1997;40(22):3497-500.
1997: José L Castro; Howard B Broughton; Michael G N Russell; D Rathbone; Alan P Watt; Richard G Ball; Kerry L Chapman; Smita Patel; Alison J Smith; George R Marshall; VG Matassa
5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.
Journal of medicinal chemistry 1997;40(16):2491-501.
1996: José L Castro; R G Ball; Howard B Broughton; Michael G N Russell; D Rathbone; Alan P Watt; R Baker; Kerry L Chapman; A E Fletcher; Smita Patel; A J Smith; George R Marshall; W Ryecroft; VG Matassa
Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas.
Journal of medicinal chemistry 1996;39(4):842-9.
1994: José L Castro; R Baker; Alec Guiblin; S C Hobbs; M R Jenkins; Michael G N Russell; Margaret S Beer; Josephine A Stanton; K Scholey; Richard Hargreaves
Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin- 2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT1D receptor.
Journal of medicinal chemistry 1994;37(19):3023-32.
1992: Michael G N Russell; R Baker; david billington
The synthesis of 2-O-alkyl-myo-inositol 1-phosphates as competitive inhibitors of inositol monophosphatase.
Carbohydrate research 1992;234():263-8.
1992: Michael G N Russell; R Baker; david billington; A K Knight; D N Middlemiss; A J Noble
Benz[f]isoquinoline analogues as high-affinity sigma ligands.
Journal of medicinal chemistry 1992;35(11):2025-33.