FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Ivan Rusyn

Research Profile

Anatomy

Living Beings

Chemicals & Drugs

Disorders

Co-author Network

Publications

TOP 3
Takeki Uehara; Jyoji Yamate; Svitlana Shymonyak; Garrett R Ainslie; Ramon Bataller; Gary A Boorman; Blair U Bradford; Takeshi Izawa; Oksana Kosyk; Kristi Kutanzi; Levan Muskhelishvili; Igor P Pogribny; Ivan Rusyn
Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.
Takeki Uehara; Katherine Tech; Volodymyr Tryndyak; Gary A Boorman; Blair U Bradford; Saurabh Chatterjee; Emmanuelle Jeannot; Oksana Kosyk; Jeffrey Macdonald; Ronald P Mason; Stepan Melnyk; Igor P Pogribny; Ivan Rusyn
Acetaminophen-induced acute liver injury in HCV transgenic mice.
Igor P Pogribny; Ivan Rusyn
Environmental toxicants, epigenetics, and cancer.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Ivan Rusyn (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Takeki Uehara; Jyoji Yamate; Svitlana Shymonyak; Garrett R Ainslie; Ramon Bataller; Gary A Boorman; Blair U Bradford; Takeshi Izawa; Oksana Kosyk; Kristi Kutanzi; Levan Muskhelishvili; Igor P Pogribny; Ivan Rusyn
Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.
Toxicological sciences : an official journal of the Society of Toxicology 2013;132(1):53-63.
2013: Takeki Uehara; Katherine Tech; Volodymyr Tryndyak; Gary A Boorman; Blair U Bradford; Saurabh Chatterjee; Emmanuelle Jeannot; Oksana Kosyk; Jeffrey Macdonald; Ronald P Mason; Stepan Melnyk; Igor P Pogribny; Ivan Rusyn
Acetaminophen-induced acute liver injury in HCV transgenic mice.
Toxicology and applied pharmacology 2013;266(2):224-32.
2013: Igor P Pogribny; Ivan Rusyn
Environmental toxicants, epigenetics, and cancer.
Advances in experimental medicine and biology 2013;754():215-32.
2012: Volodymyr Tryndyak; Sharon A Ross; Ivan Rusyn; Frederick A Beland; John R Latendresse; Beverly Montgomery; Igor P Pogribny
Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet.
Toxicology and applied pharmacology 2012;262(1):52-9.
2012: Masato Tsuchiya; Svitlana Shymonyak; Volodymyr Tryndyak; Cheng Ji; Neil Kaplowitz; Hiroshi Kono; Oksana Kosyk; Stepan Melnyk; Levan Muskhelishvili; Igor P Pogribny; Ivan Rusyn
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice.
Hepatology (Baltimore, Md.) 2012;56(1):130-9.
2012: Ivan Rusyn; Alexander Sedykh; Kathryn Z Guyton; Yen Low; Alexander Tropsha
Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(1):1-9.
2012: Karin Yeatts; Taoufik Zoubeidi; Ivan Rusyn; Chris B Trent; Fatma Al-maskari; Maryanne G Boundy; Ronna L Chan; David Couper; Christopher A Davidson; Mohamed El-Sadig; William E Funk; Jacqueline MacDonald Gibson; Mohamed Y Hasan; William Kalsbeek; Maamoon M Kassab; David Leith; Andrew F Olshan
Indoor air pollutants and health in the United Arab Emirates.
Environmental health perspectives 2012;120(5):687-94.
2012: Karin Yeatts; Barry Popkin; Lisa Reeves; Ivan Rusyn; Habiba I Ali; Fatma Al-maskari; Maryanne G Boundy; Alan Campbell; Ronna L Chan; Christopher A Davidson; Mohamed El-Sadig; William E Funk; Jacqueline Macdonald Gibson; David Leith; Shu Wen Ng; Andrew F Olshan
Conducting environmental health research in the Arabian Middle East: lessons learned and opportunities.
Environmental health perspectives 2012;120(5):632-6.
2012: Eric F Lock; Shannon H O'Shea; Nour Abdo; Christopher P Austin; Ruili Huang; Oksana Kosyk; Alexander Sedykh; Raymond R Tice; Alexander Tropsha; Fred A Wright; Menghang Xia; Yi-Hui Zhou; Ivan Rusyn
Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(2):578-88.
2012: Ivan Rusyn; J Christopher Corton
Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate.
Mutation research 2012;750(2):141-58.
2012: Emmanuelle Jeannot; Oksana Kosyk; Stepan B Melnyk; Igor P Pogribny; Svitlana Shymoniak; Volodymyr Tryndyak; Batbayar Tumurbaatar; Steven A Weinman; Gary A Boorman; Blair U Bradford; Ivan Rusyn
Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice.
International journal of cancer. Journal international du cancer 2012;130(6):1347-56.
2012: Fred A Wright; Andrey A Shabalin; Ivan Rusyn
Computational tools for discovery and interpretation of expression quantitative trait loci.
Pharmacogenomics 2012;13(3):343-52.
2011: Anne M Hakenewerth; Amy H Herring; Robert C Millikan; Kari E North; Jill S Barnholtz-Sloan; William F Funkhouser; Ivan Rusyn; Mark C Weissler; Andrew F Olshan
Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011;20(11):2438-49.
2011: Daniel M Gatti; Lu Lu; Wei Sun; David W Threadgill; Robert W Williams; Fred A Wright; Ivan Rusyn
MicroRNA expression in the livers of inbred mice.
Mutation research 2011;714(1-2):126-33.
2011: Yen Low; Yohsuke Minowa; Eugene Muratov; Yasuo Ohno; Ivan Rusyn; Alexander Sedykh; Takeki Uehara; Tetsuro Urushidani; Hiroshi Yamada; Hao Zhu; Denis Fourches; Viktor Kuz'min; Alexander Tropsha
Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches.
Chemical research in toxicology 2011;24(8):1251-62.
2011: Igor Koturbash; Fernando Pardo-Manuel Devillena; Frederick A Beland; Wanda Bodnar; Ivan Rusyn; Anne Scherhag; Kenneth Sexton; Jessica Sorrentino; James A Swenberg; Igor P Pogribny
Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(2):448-56.
2011: Igor Koturbash; Anne Scherhag; Jessica Sorrentino; Kenneth Sexton; Wanda Bodnar; Volodymyr Tryndyak; John R Latendresse; James A Swenberg; Frederick A Beland; Igor P Pogribny; Ivan Rusyn
Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene.
Environmental health perspectives 2011;119(5):635-40.
2011: Blair U Bradford; Eric F Lock; Oksana Kosyk; Sungkyoon Kim; Takeki Uehara; David Harbourt; Michelle DeSimone; David Threadgill; Volodymyr Tryndyak; Igor P Pogribny; Lisa Bleyle; Dennis R Koop; Ivan Rusyn
Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice.
Toxicological sciences : an official journal of the Society of Toxicology 2011;120(1):206-17.
2011: Alexander Sedykh; Hao Zhu; Hao Tang; Liying Zhang; Ann Richard; Ivan Rusyn; Alexander Tropsha
Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity.
Environmental health perspectives 2011;119(3):364-70.
2011: Emmanuelle Jeannot; Igor P Pogribny; Frederick A Beland; Ivan Rusyn
Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells.
Cancer letters 2011;301(2):161-7.
2011: Shannon H O'Shea; John Schwarz; Oksana Kosyk; Pamela K Ross; Min Jin Ha; Fred A Wright; Ivan Rusyn
In vitro screening for population variability in chemical toxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(2):398-407.
2010: Stephanie M Martinez; Blair U Bradford; Valerie Y Soldatow; Oksana Kosyk; Amelia Sandot; Rafal Witek; Robert Kaiser; Todd Stewart; Kirsten Amaral; Kimberly Freeman; Chris Black; Edward LeCluyse; Stephen S Ferguson; Ivan Rusyn
Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity.
Toxicology and applied pharmacology 2010;249(3):208-16.
2010: Eric J Formeister; Masato Tsuchiya; Hideki Fujii; Svitlana Shpyleva; Igor P Pogribny; Ivan Rusyn
Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma.
Mutation research 2010;692(1-2):26-33.
2010: Rachael B Cowherd; Rachael B Cowerd; Melissa M Asmar; J McKee Alderman; Elizabeth A Alderman; Alaina L Garland; Walker H Busby; Wanda M Bodnar; Ivan Rusyn; Benjamin D Medoff; Roland Tisch; Elizabeth Mayer-Davis; James A Swenberg; Steven H Zeisel; Terry P Combs
Adiponectin lowers glucose production by increasing SOGA.
The American journal of pathology 2010;177(4):1936-45.
2010: Igor P Pogribny; Athena Starlard-Davenport; Volodymyr Tryndyak; Tao Han; Sharon A Ross; Ivan Rusyn; Frederick A Beland
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice.
Laboratory investigation; a journal of technical methods and pathology 2010;90(10):1437-46.
2010: Ivan Rusyn; Daniel M Gatti; Timothy Wiltshire; Timothy Wilshire; Steven R Kleeberger; David W Threadgill
Toxicogenetics: population-based testing of drug and chemical safety in mouse models.
Pharmacogenomics 2010;11(8):1127-36.
2010: Daniel M Gatti; Ni Zhao; Elissa J Chesler; Blair U Bradford; Andrey A Shabalin; Roumyana Yordanova; Lu Lu; Ivan Rusyn
Sex-specific gene expression in the BXD mouse liver.
Physiological genomics 2010;42(3):456-68.
2010: Ivan Rusyn; George P Daston
Computational toxicology: realizing the promise of the toxicity testing in the 21st century.
Environmental health perspectives 2010;118(8):1047-50.
2010: Emmanuelle Jeannot; Lucille Mellottee; Paulette Bioulac-Sage; Charles Balabaud; Jean-Yves Scoazec; Jeanne Tran Van Nhieu; Yannick Bacq; Sophie Michalak; David Buob; Pierre Laurent-Puig; Ivan Rusyn; Jessica Zucman-Rossi
Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage.
Diabetes 2010;59(7):1836-44.
2010: Christine L Powell; Blair U Bradford; Christopher Patrick Craig; Masato Tsuchiya; Takeki Uehara; Thomas M O'Connell; Igor P Pogribny; Stepan Melnyk; Dennis R Koop; Lisa Bleyle; David Threadgill; Ivan Rusyn
Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors.
Toxicological sciences : an official journal of the Society of Toxicology 2010;115(1):131-9.
2010: Amie D Rodgers; Hao Zhu; Denis Fourches; Ivan Rusyn; Alexander Tropsha
Modeling liver-related adverse effects of drugs using knearest neighbor quantitative structure-activity relationship method.
Chemical research in toxicology 2010;23(4):724-32.
2010: Athena Starlard-Davenport; Volodymyr Tryndyak; Oksana Kosyk; Sharon R Ross; Ivan Rusyn; Frederick A Beland; Igor P Pogribny
Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.
Journal of nutrigenetics and nutrigenomics 2010;3(4-6):259-66.
2010: Daniel M Gatti; William T Barry; Andrew B Nobel; Ivan Rusyn; Fred A Wright
Heading down the wrong pathway: on the influence of correlation within gene sets.
BMC genomics 2010;11():574.
2010: Athena Starlard-Davenport; Volodymyr Tryndyak; Oksana Kosyk; Sharon R Ross; Ivan Rusyn; Frederick A Beland; Igor P Pogribny
Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.
World review of nutrition and dietetics 2010;101():123-30.
2010: Masato Tsuchiya; Joel Parker; Hiroshi Kono; Masanori Matsuda; Hideki Fujii; Ivan Rusyn
Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma.
Molecular cancer 2010;9():74.
2009: Alison Hege Harrill; Paul B Watkins; Stephen Su; Pamela K Ross; David E Harbourt; Ioannis M Stylianou; Gary A Boorman; Mark W Russo; Richard S Sackler; Stephen C Harris; Philip C Smith; Raymond Tennant; Molly Bogue; Kenneth Paigen; Christopher Harris; Tanupriya Contractor; Timothy Wiltshire; Ivan Rusyn; David Threadgill
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.
Genome research 2009;19(9):1507-15.
2009: Sungkyoon Kim; Leonard B Collins; Gunnar Boysen; James A Swenberg; Avram Gold; Louise M Ball; Blair U Bradford; Ivan Rusyn
Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
Toxicology 2009;262(3):230-8.
2009: Hao Zhu; Lin Ye; Ann Richard; Alexander Golbraikh; Fred A Wright; Ivan Rusyn; Alexander Tropsha
A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents.
Environmental health perspectives 2009;117(8):1257-64.
2009: Daniel M Gatti; Alison Hege Harrill; Fred A Wright; David Threadgill; Ivan Rusyn
Replication and narrowing of gene expression quantitative trait loci using inbred mice.
Mammalian genome : official journal of the International Mammalian Genome Society 2009;20(7):437-46.
2009: Igor P Pogribny; Volodymyr Tryndyak; Tetyana V Bagnyukova; Stepan Melnyk; Beverly Montgomery; Sharon A Ross; John R Latendresse; Ivan Rusyn; Frederick A Beland
Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.
Journal of hepatology 2009;51(1):176-86.
2009: Alison Hege Harrill; Pamela K Ross; Daniel M Gatti; David Threadgill; Ivan Rusyn
Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(1):235-43.
2009: Sungkyoon Kim; David Kim; Gary M Pollack; Leonard B Collins; Ivan Rusyn
Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
Toxicology and applied pharmacology 2009;238(1):90-9.
2009: Pamela K Ross; courtney woods; Blair U Bradford; Oksana Kosyk; Daniel M Gatti; Michael L Cunningham; Ivan Rusyn
Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver.
Toxicology and applied pharmacology 2009;235(2):199-207.
2009: Daniel M Gatti; Myroslav Sypa; Ivan Rusyn; Fred A Wright; William T Barry
SAFEGUI: resampling-based tests of categorical significance in gene expression data made easy.
Bioinformatics (Oxford, England) 2009;25(4):541-2.
2009: Daniel M Gatti; Andrey A Shabalin; Tieu-Chong Lam; Fred A Wright; Ivan Rusyn; Andrew B Nobel
FastMap: fast eQTL mapping in homozygous populations.
Bioinformatics (Oxford, England) 2009;25(4):482-9.
2008: Masato Tsuchiya; Hiroshi Kono; Masanori Matsuda; Hideki Fujii; Ivan Rusyn
Protective effect of Juzen-taiho-to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell-induced oxidative stress.
International journal of cancer. Journal international du cancer 2008;123(11):2503-11.
2008: Alison Hege Harrill; Ivan Rusyn
Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity.
Expert opinion on drug metabolism & toxicology 2008;4(11):1379-89.
2008: Blair U Bradford; Thomas O Connell; Jun Han; Oksana Kosyk; Svitlana Shymonyak; Pamela K Ross; Jason Winnike; Hiroshi Kono; Ivan Rusyn
Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease.
Toxicology and applied pharmacology 2008;232(2):236-43.
2008: Igor P Pogribny; Volodymyr Tryndyak; Anna Boureiko; Stepan Melnyk; Tetyana V Bagnyukova; Beverly Montgomery; Ivan Rusyn
Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.
Mutation research 2008;644(1-2):17-23.
2008: Hao Zhu; Ivan Rusyn; Ann Richard; Alexander Tropsha
Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity.
Environmental health perspectives 2008;116(4):506-13.
2008: Igor P Pogribny; Ivan Rusyn; Frederick A Beland
Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents.
Environmental and molecular mutagenesis 2008;49(1):9-15.
2007: courtney woods; Oksana Kosyk; Blair U Bradford; Pamela K Ross; Amanda M Burns; Michael L Cunningham; Pingping Qu; Joseph G Ibrahim; Ivan Rusyn
Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression.
Toxicology and applied pharmacology 2007;225(3):267-77.
2007: Igor P Pogribny; Volodymyr Tryndyak; courtney woods; Sarah E Witt; Ivan Rusyn
Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha.
Mutation research 2007;625(1-2):62-71.
2007: Richard P Beyer; Rebecca Fry; Michael R Lasarev; Lisa A McConnachie; Lisiane Meira; Valerie S Palmer; Christine L Powell; Pamela K Ross; Theo K Bammler; Blair U Bradford; Alex B Cranson; Michael L Cunningham; Rickie D Fannin; Gregory M Higgins; Patrick Hurban; Robert J Kayton; Kathleen F Kerr; Oksana Kosyk; Edward K Lobenhofer; Stella O Sieber; Portia A Vliet; Brenda K Weis; Russel Wolfinger; courtney woods; Jonathan H Freedman; Elwood Linney; William K Kaufmann; Terrance J Kavanagh; Richard S Paules; Ivan Rusyn; Leona D Samson; Peter S Spencer; William Suk; Raymond J Tennant; Helmut Zarbl
Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses.
Toxicological sciences : an official journal of the Society of Toxicology 2007;99(1):326-37.
2007: Richard Peffer; Jonathan G Moggs; Timothy Pastoor; Richard A Currie; Jayne Wright; Gill Milburn; Felix Waechter; Ivan Rusyn
Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor.
Toxicological sciences : an official journal of the Society of Toxicology 2007;99(1):315-25.
2007: Daniel Gatti; Akira Maki; Elissa J Chesler; Roumyana Kirova; Oksana Kosyk; Lu Lu; Kenneth F Manly; Robert Williams; Andy Perkins; Michael A Langston; David Threadgill; Ivan Rusyn
Genome-level analysis of genetic regulation of liver gene expression networks.
Hepatology (Baltimore, Md.) 2007;46(2):548-57.
2007: courtney woods; Amanda M Burns; Blair U Bradford; Pamela K Ross; Oksana Kosyk; James A Swenberg; Michael L Cunningham; Ivan Rusyn
WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(2):366-74.
2007: Adam Roberts; Leonard McMillan; Wei Wang; Joel Parker; Ivan Rusyn; David Threadgill
Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows.
Bioinformatics (Oxford, England) 2007;23(13):i401-7.
2007: Shunhei Yamashina; Kenichi Ikejima; Ivan Rusyn; Nobuhiro Sato
Glycine as a potent anti-angiogenic nutrient for tumor growth.
Journal of gastroenterology and hepatology 2007;22 Suppl 1():S62-4.
2007: courtney woods; John P Vanden Heuvel; Ivan Rusyn
Genomic profiling in nuclear receptor-mediated toxicity.
Toxicologic pathology 2007;35(4):474-94.
2007: Linda E Hammond; Craig D Albright; Lihua He; Ivan Rusyn; Steven M Watkins; Scott D Doughman; John J Lemasters; Rosalind A Coleman
Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice.
Experimental and molecular pathology 2007;82(2):210-9.
2007: Akira Maki; Hiroshi Kono; Mayetri Gupta; Masami Asakawa; Tetsuya Suzuki; Masanori Matsuda; Hideki Fujii; Ivan Rusyn
Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma.
Annals of surgical oncology 2007;14(3):1182-90.
2007: Ruth A Roberts; Patricia E Ganey; Cynthia Ju; Lisa M Kamendulis; Ivan Rusyn; James Klaunig
Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis.
Toxicological sciences : an official journal of the Society of Toxicology 2007;96(1):2-15.
2007: courtney woods; Amanda M Burns; Akira Maki; Blair U Bradford; Michael L Cunningham; Henry D Connor; Maria B Kadiiska; Ronald P Mason; Jeffrey M Peters; Ivan Rusyn
Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase.
Free radical biology & medicine 2007;42(3):335-42.
2007: Ivan Rusyn; Rebecca Fry; Thomas Begley; Joanna Klapacz; J Peter Svensson; Mark Ambrose; Leona D Samson
Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates.
PloS one 2007;2(11):e1252.
2007: Igor P Pogribny; Volodymyr Tryndyak; Levan Muskhelishvili; Ivan Rusyn; Sharon A Ross
Methyl deficiency, alterations in global histone modifications, and carcinogenesis.
The Journal of nutrition 2007;137(1 Suppl):216S-222S.
2006: Christine L Powell; Oksana Kosyk; Pamela K Ross; Robert Schoonhoven; Gunnar Boysen; James A Swenberg; Alexandra N Heinloth; Gary A Boorman; Michael L Cunningham; Richard S Paules; Ivan Rusyn
Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver.
Toxicological sciences : an official journal of the Society of Toxicology 2006;93(1):213-22.
2006: Hiroshi Kono; courtney woods; Akira Maki; Henry D Connor; Ronald P Mason; Ivan Rusyn; Hideki Fujii
Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage.
Free radical research 2006;40(6):579-88.
2006: Ivan Rusyn; Jeffrey M Peters; Michael L Cunningham
Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver.
Critical reviews in toxicology 2006;36(5):459-79.
2005: Christine L Powell; James A Swenberg; Ivan Rusyn
Expression of base excision DNA repair genes as a biomarker of oxidative DNA damage.
Cancer letters 2005;229(1):1-11.
2005: Christine L Powell; Oksana Kosyk; Blair U Bradford; Joel Parker; Edward K Lobenhofer; Ayumi Denda; Fumiyuki Uematsu; Dai Nakae; Ivan Rusyn
Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury.
Hepatology (Baltimore, Md.) 2005;42(5):1137-47.
2005: Ivan Rusyn; Shoji Asakura; Yutai Li; Oksana Kosyk; Hasan Koc; Jun Nakamura; Patricia B Upton; James A Swenberg
Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver.
DNA repair 2005;4(10):1099-110.
2005: Fumiyuki Uematsu; Masakazu Takahashi; Midori Yoshida; Maki Igarashi; Naoto Watanabe; Noriko Suzuki; Masayoshi Abe; Ivan Rusyn; Robert A Floyd; Dai Nakae
Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non-cancerous, cirrhotic liver tissues in rats fed a choline-deficient, L-amino acid-defined diet.
Cancer science 2005;96(7):414-24.
2005: Theodore Bammler; Richard P Beyer; Sanchita Bhattacharya; Gary A Boorman; Abee Boyles; Blair U Bradford; Roger Bumgarner; Pierre R Bushel; Kabir Chaturvedi; Dongseok Choi; Michael L Cunningham; Shibing Deng; Holly K Dressman; Rickie D Fannin; Fredrico M Farin; Jonathan H Freedman; Rebecca Fry; Angel Harper; Michael C Humble; Patrick Hurban; Terrance J Kavanagh; William K Kaufmann; Kathleen F Kerr; Li Jing; Jodi A Lapidus; Michael R Lasarev; Jianying Li; Yi-Ju Li; Edward K Lobenhofer; Xinfang Lu; Renae L Malek; Sean Milton; Srinivasa R Nagalla; Jean P O'malley; Valerie S Palmer; Patrick Pattee; Richard S Paules; Charles M Perou; Ken Phillips; Li-Xuan Qin; Yang Qiu; Sean D Quigley; Matthew Rodland; Ivan Rusyn; Leona D Samson; David A Schwartz; Yan Shi; Jung-Lim Shin; Stella O Sieber; Susan Slifer; Marcy C Speer; Peter S Spencer; Dean I Sproles; James A Swenberg; William A Suk; Robert C Sullivan; Ru Tian; Raymond W Tennant; Signe A Todd; Charles J Tucker; Bennett Van Houten; Brenda K Weis; Shirley Xuan; Helmut Zarbl
Standardizing global gene expression analysis between laboratories and across platforms.
Nature methods 2005;2(5):351-6.
2005: Blair U Bradford; Hiroshi Kono; Fuyumi Isayama; Oksana Kosyk; Michael D Wheeler; Taro E Akiyama; Lisa Bleye; Kristopher W Krausz; Frank J Gonzalez; Dennis R Koop; Ivan Rusyn
Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver.
Hepatology (Baltimore, Md.) 2005;41(2):336-44.
2005: Blair U Bradford; Ivan Rusyn
Swift increase in alcohol metabolism (SIAM): understanding the phenomenon of hypermetabolism in liver.
Alcohol (Fayetteville, N.Y.) 2005;35(1):13-7.
2005: Thomas Hays; Ivan Rusyn; Amanda M Burns; Mary J. Kennett; Jerrold M Ward; Frank J Gonzalez; Jeffrey M Peters
Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.
Carcinogenesis 2005;26(1):219-27.
2004: Ivan Rusyn; Shoji Asakura; Brian F Pachkowski; Blair U Bradford; Mikhail F Denissenko; Jeffrey M Peters; Steven M Holland; Janardan K Reddy; Michael L Cunningham; James A Swenberg
Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators.
Cancer research 2004;64(3):1050-7.
2003: Michael D Wheeler; Olivia M Smutney; Jennifer F Check; Ivan Rusyn; R Schulte-Hermann; Ronald G Thurman
Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomy.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(2):G302-12.
2002: Hiroshi Kono; Hideki Fujii; Masami Asakawa; Masayuki Yamamoto; Akira Maki; Masanori Matsuda; Ivan Rusyn; Yoshiro Matsumoto
Functional heterogeneity of the kupffer cell population is involved in the mechanism of gadolinium chloride in rats administered endotoxin.
The Journal of surgical research 2002;106(1):179-87.
2002: Ming Yin; Zhi Zhong; Henry D Connor; Hartwig Bunzendahl; William F Finn; Ivan Rusyn; Xiangli Li; James Raleigh; Ronald P Mason; Ronald G Thurman
Protective effect of glycine on renal injury induced by ischemia-reperfusion in vivo.
American journal of physiology. Renal physiology 2002;282(3):F417-23.
2001: Michael D Wheeler; Hiroshi Kono; M Yin; M Nakagami; Takehiko Uesugi; Gavin E Arteel; Erwin Gäbele; Ivan Rusyn; S Yamashina; Matthias Froh; Y Adachi; Yuji Iimuro; Blair U Bradford; Olivia M Smutney; Henry D Connor; Ronald P Mason; Sanna Goyert; J M Peters; F J Gonzalez; R Jude Samulski; Ronald G Thurman
The role of Kupffer cell oxidant production in early ethanol-induced liver disease.
Free radical biology & medicine 2001;31(12):1544-9.
2001: Ivan Rusyn
In memoriam: Ronald G. Thurman (1941-2001).
Carcinogenesis 2001;22(12):1899-901.
2001: M Yin; Erwin Gäbele; Michael D Wheeler; Henry D Connor; Blair U Bradford; Anna Dikalova; Ivan Rusyn; R Mason; Ronald G Thurman
Alcohol-induced free radicals in mice: direct toxicants or signaling molecules?
Hepatology (Baltimore, Md.) 2001;34(5):935-42.
2001: Shiyao Xu; Bao Ting Zhu; VK Turan; Ivan Rusyn; R Thurman; J M Peters; F J Gonzalez; Allan H Conney
PPARalpha-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator.
Endocrinology 2001;142(8):3554-7.
2001: Hiroshi Kono; Takehiko Uesugi; Matthias Froh; Ivan Rusyn; Blair U Bradford; Ronald G Thurman
ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(6):G1289-95.
2001: Hiroshi Kono; M Nakagami; Ivan Rusyn; Henry D Connor; Branko Stefanovic; David A Brenner; Ronald P Mason; Gavin E Arteel; Ronald G Thurman
Development of an animal model of chronic alcohol-induced pancreatitis in the rat.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(6):G1178-86.
2001: Hiroshi Kono; Ivan Rusyn; Takehiko Uesugi; S Yamashina; Henry D Connor; Anna Dikalova; Ronald P Mason; Ronald G Thurman
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(5):G1005-12.
2001: Michael D Wheeler; S Yamashina; Matthias Froh; Ivan Rusyn; Ronald G Thurman
Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF-kappaB activation and cytokine production.
Journal of leukocyte biology 2001;69(4):622-30.
2001: Michael D Wheeler; Hiroshi Kono; M Yin; Ivan Rusyn; Matthias Froh; Henry D Connor; Ronald P Mason; R Jude Samulski; Ronald G Thurman
Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats.
Gastroenterology 2001;120(5):1241-50.
2001: Ivan Rusyn; Maria B Kadiiska; Anna Dikalova; Hiroshi Kono; M Yin; K Tsuchiya; Ronald P Mason; J M Peters; F J Gonzalez; BH Segal; SM Holland; Ronald G Thurman
Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells.
Molecular pharmacology 2001;59(4):744-50.
2001: Hiroshi Kono; Gavin E Arteel; Ivan Rusyn; Helmut Sies; Ronald G Thurman
Ebselen prevents early alcohol-induced liver injury in rats.
Free radical biology & medicine 2001;30(4):403-11.
2001: S Yamashina; A Konno; Michael D Wheeler; Ivan Rusyn; Elena V Rusyn; Adrienne D Cox; Ronald G Thurman
Endothelial cells contain a glycine-gated chloride channel.
Nutrition and cancer 2001;40(2):197-204.
2000: Ivan Rusyn; Mikhail F Denissenko; Victoria A Wong; Byron E Butterworth; Michael L Cunningham; Patricia B Upton; Ronald G Thurman; James A Swenberg
Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency.
Carcinogenesis 2000;21(12):2141-5.
2000: S Yamashina; Michael D Wheeler; Ivan Rusyn; Kenichi Ikejima; Nobuhiro Sato; Ronald G Thurman
Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor-associated kinase.
Biochemical and biophysical research communications 2000;277(3):686-90.
2000: Michael D Wheeler; Hiroshi Kono; Ivan Rusyn; Gavin E Arteel; Douglass Mccarty; R Jude Samulski; Ronald G Thurman
Chronic ethanol increases adeno-associated viral transgene expression in rat liver via oxidant and NFkappaB-dependent mechanisms.
Hepatology (Baltimore, Md.) 2000;32(5):1050-9.
2000: Hiroshi Kono; Ivan Rusyn; M Yin; Erwin Gäbele; S Yamashina; Anna Dikalova; Maria B Kadiiska; Henry D Connor; Ronald P Mason; BH Segal; Blair U Bradford; SM Holland; Ronald G Thurman
NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.
The Journal of clinical investigation 2000;106(7):867-72.
2000: Ivan Rusyn; S Yamashina; BH Segal; Robert Schoonhoven; SM Holland; Russell C Cattley; James A Swenberg; Ronald G Thurman
Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.
Cancer research 2000;60(17):4798-803.
2000: Hiroshi Kono; Michael D Wheeler; Ivan Rusyn; M Lin; VITOR SEABRA; CA Rivera; Blair U Bradford; Donald Forman; Ronald G Thurman
Gender differences in early alcohol-induced liver injury: role of CD14, NF-kappaB, and TNF-alpha.
American journal of physiology. Gastrointestinal and liver physiology 2000;278(4):G652-61.
2000: Jeffrey M Peters; Ivan Rusyn; M L Rose; Frank J Gonzalez; R G Thurman
Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.
Carcinogenesis 2000;21(4):823-6.
2000: Hiroshi Kono; Ivan Rusyn; Blair U Bradford; Henry D Connor; Ronald P Mason; Ronald G Thurman
Allopurinol prevents early alcohol-induced liver injury in rats.
The Journal of pharmacology and experimental therapeutics 2000;293(1):296-303.
2000: ML Rose; Ivan Rusyn; HK Bojes; J Belyea; Russell C Cattley; Ronald G Thurman
Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation.
Mutation research 2000;448(2):179-92.
2000: M Yin; Ivan Rusyn; Robert Schoonhoven; Lee M Graves; Elena V Rusyn; X Li; F Li; Adrienne D Cox; T W Harding; Hartwig Bunzendahl; James A Swenberg; Ronald G Thurman
Inhibition of chronic rejection of aortic allografts by dietary glycine.
Transplantation 2000;69(5):773-80.
2000: Yuji Iimuro; Blair U Bradford; S Yamashina; Ivan Rusyn; M Nakagami; N Enomoto; Hiroshi Kono; W Frey; Donald Forman; David A Brenner; Ronald G Thurman
The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat.
Hepatology (Baltimore, Md.) 2000;31(2):391-8.
2000: Ivan Rusyn; ML Rose; HK Bojes; Ronald G Thurman
Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators.
Antioxidants & redox signaling 2000;2(3):607-21.
2000: Hiroshi Kono; Blair U Bradford; Ivan Rusyn; H Fujii; Y Matsumoto; M Yin; Ronald G Thurman
Development of an intragastric enteral model in the mouse: studies of alcohol-induced liver disease using knockout technology.
Journal of hepato-biliary-pancreatic surgery 2000;7(4):395-400.
1999: Michael D Wheeler; K Ikejema; N Enomoto; R F Stacklewitz; VITOR SEABRA; Zhi Zhong; M Yin; Peter Schemmer; ML Rose; Ivan Rusyn; Blair U Bradford; Ronald G Thurman
Glycine: a new anti-inflammatory immunonutrient.
Cellular and molecular life sciences : CMLS 1999;56(9-10):843-56.
1999: Ivan Rusyn; Cynthia A Bradham; L Cohn; Robert Schoonhoven; James A Swenberg; David A Brenner; Ronald G Thurman
Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms.
Carcinogenesis 1999;20(11):2095-100.
1999: Gavin E Arteel; Maria B Kadiiska; Ivan Rusyn; Blair U Bradford; Ronald P Mason; James Raleigh; Ronald G Thurman
Oxidative stress occurs in perfused rat liver at low oxygen tension by mechanisms involving peroxynitrite.
Molecular pharmacology 1999;55(4):708-15.
1999: Robert Stachlewitz; VITOR SEABRA; Blair U Bradford; Cynthia A Bradham; Ivan Rusyn; Dori R Germolec; Ronald G Thurman
Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: role of Kupffer cells.
Hepatology (Baltimore, Md.) 1999;29(3):737-45.
1999: ML Rose; Ivan Rusyn; HK Bojes; Dori R Germolec; M Luster; Ronald G Thurman
Role of Kupffer cells in peroxisome proliferator-induced hepatocyte proliferation.
Drug metabolism reviews 1999;31(1):87-116.
1998: M Yin; Kenichi Ikejima; Gavin E Arteel; VITOR SEABRA; Blair U Bradford; Hiroshi Kono; Ivan Rusyn; Ronald G Thurman
Glycine accelerates recovery from alcohol-induced liver injury.
The Journal of pharmacology and experimental therapeutics 1998;286(2):1014-9.
1998: Ivan Rusyn; H Tsukamoto; Ronald G Thurman
WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes.
Carcinogenesis 1998;19(7):1217-22.
1996: Bernd Epe; Daniel Ballmaier; Ivan Rusyn; K Briviba; Helmut Sies
DNA damage by peroxynitrite characterized with DNA repair enzymes.
Nucleic acids research 1996;24(21):4105-10.
1996: K Briviba; Ivan Rusyn; V S Sharov; Helmut Sies
Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen.
The Biochemical journal 1996;319 ( Pt 1)():13-5.
1996: Ivan Rusyn; K Briviba; H Masumoto; Helmut Sies
Selenium-containing compounds protect DNA from single-strand breaks caused by peroxynitrite.
Archives of biochemistry and biophysics 1996;330(1):216-8.