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Martin Ruthardt

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Annette Romanski; Jessica Roos; Martin Ruthardt; Kerstin Schwarz; Hubert Serve; Anja Vogel; Sarah Wietbrauk; Boris Brill; Maren Keller; Oliver H Krämer; Claudia Oancea; Gesine Bug
Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.
Afsar A Mian; Yousef Najajreh; Oliver G Ottmann; Jamal Mahajna; Anna Metodieva; Martin Ruthardt
p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia.
Mamduh Khateb; Hazem Khamisie; Anna Metodieva; Afsar Mian; Yousef Najajreh; Nili Ruimi; Martin Ruthardt; Jamal Mahajna
Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism.

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2012: Annette Romanski; Jessica Roos; Martin Ruthardt; Kerstin Schwarz; Hubert Serve; Anja Vogel; Sarah Wietbrauk; Boris Brill; Maren Keller; Oliver H Krämer; Claudia Oancea; Gesine Bug
Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.
Cell cycle (Georgetown, Tex.) 2012;11(17):3219-26.
2012: Afsar A Mian; Yousef Najajreh; Oliver G Ottmann; Jamal Mahajna; Anna Metodieva; Martin Ruthardt
p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia.
Haematologica 2012;97(2):251-7.
2012: Mamduh Khateb; Hazem Khamisie; Anna Metodieva; Afsar Mian; Yousef Najajreh; Nili Ruimi; Martin Ruthardt; Jamal Mahajna
Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism.
BMC cancer 2012;12():563.
2012: Afsar Ali Mian; Yousef Najajreh; Oliver Gerhard Ottmann; Nili Ruimi; Susanne Badura; Mamduh Khateb; Jamal Mahajna; Anna Metodieva; Martin Ruthardt
Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I.
BMC cancer 2012;12():411.
2011: Gunnar Steinert; Jessica Roos; Martin Ruthardt; Heike Hagemeyer; Thorsten Maier; Claudia Oancea; Elena Puccetti
Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARα and PLZF/RARα.
PloS one 2011;6(7):e22540.
2011: Hazem Khamaisie; Sherbel Sussan; Michael Tal; Yousef Najajreh; Martin Ruthardt; Jamal Mahajna
Oleic acid is the active component in the mushroom Daedalea gibbosa inhibiting Bcr-Abl kinase autophosphorylation activity.
Anticancer research 2011;31(1):177-83.
2010: C Oancea; Brigitte Rüster; Reinhard Henschler; Elena Puccetti; Martin Ruthardt
The t(6;9) associated DEK/CAN fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation.
Leukemia 2010;24(11):1910-9.
2010: Adelheid Bursen; Karen Schwabe; Brigitte Rüster; Reinhard Henschler; Martin Ruthardt; Theo Dingermann; Rolf Marschalek
The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.
Blood 2010;115(17):3570-9.
2010: Dieter Steinhilber; Astrid Stefanie Fischer; Julia Metzner; Jessica Roos; Martin Ruthardt; Svenja Dorothea Steinbrink; Thorsten J Maier
5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis.
Frontiers in pharmacology 2010;1():143.
2009: A A Mian; C Oancea; Z Zhao; Oliver G Ottmann; Martin Ruthardt
Oligomerization inhibition, combined with allosteric inhibition, abrogates the transformation potential of T315I-positive BCR/ABL.
Leukemia 2009;23(12):2242-7.
2009: A A Mian; M Schüll; Z Zhao; C Oancea; A Hundertmark; Tim Beissert; Oliver G Ottmann; Martin Ruthardt
The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL.
Leukemia 2009;23(9):1614-21.
2009: Xiaomin Zheng; Claudia Oancea; Reinhard Henschler; Martin Ruthardt
Cooperation between constitutively activated c-Kit signaling and leukemogenic transcription factors in the determination of the leukemic phenotype in murine hematopoietic stem cells.
International journal of oncology 2009;34(6):1521-31.
2009: Xiaomin Zheng; Claudia Oancea; Reinhard Henschler; Malcolm A S Moore; Martin Ruthardt
Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment.
PloS one 2009;4(10):e7661.
2009: Patricia Mambou Gwanmesia; Annette Romanski; Kerstin Schwarz; Biserka Bacic; Martin Ruthardt; Oliver G Ottmann
The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines.
BMC cancer 2009;9():53.
2008: Tim Beissert; Alena Hundertmark; Velina Kaburova; Lorena Travaglini; Afsar A Mian; Clara Nervi; Martin Ruthardt
Targeting of the N-terminal coiled coil oligomerization interface by a helix-2 peptide inhibits unmutated and imatinib-resistant BCR/ABL.
International journal of cancer. Journal international du cancer 2008;122(12):2744-52.
2008: Kallal Pramanik; Sandra Trüpschuch; Axel Greiner; Martin Ruthardt; Reinhard Henschler; Albrecht M Müller
The aorta-gonad-mesonephros-derived stroma cell line DAS104-4 induces differentiation of leukemic cells.
Leukemia research 2008;32(5):781-9.
2007: Daniel Nowak; Simone Boehrer; Simone Hochmuth; Bettina Trepohl; Wencke Hofmann; Dieter Hoelzer; Wolf-Karsten Hofmann; Paris S Mitrou; Martin Ruthardt; Kai Uwe Chow
Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells.
Anti-cancer drugs 2007;18(9):981-95.
2007: Gesine Bug; Kerstin Schwarz; Claudia Schoch; Manuela Kampfmann; Reinhard Henschler; Dieter Hoelzer; Oliver G Ottmann; Martin Ruthardt
Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.
Haematologica 2007;92(4):542-5.
2007: Xiaomin Zheng; Anita Seshire; Brigitte Rüster; Gesine Bug; Tim Beissert; Elena Puccetti; Dieter Hoelzer; Reinhard Henschler; Martin Ruthardt
Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells.
Haematologica 2007;92(3):323-31.
2007: Asumi Yokota; Shinya Kimura; Satohiro Masuda; Eishi Ashihara; Junya Kuroda; Kiyoshi Sato; Yuri Kamitsuji; Eri Kawata; Yasuyuki Deguchi; Yoshimasa URASAKI; Yasuhito Terui; Martin Ruthardt; Takanori Ueda; Kiyohiko Hatake; Ken-ichi Inui; Taira Maekawa
INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity.
Blood 2007;109(1):306-14.
2006: Simone Boehrer; Daniel Nowak; Elena Puccetti; Martin Ruthardt; Nicole Sattler; Bettina Trepohl; Bernd Schneider; Dieter Hoelzer; Paris S Mitrou; Kai Uwe Chow
Prostate-apoptosis-response-gene-4 increases sensitivity to TRAIL-induced apoptosis.
Leukemia research 2006;30(5):597-605.
2006: Xiaomin Zheng; Saskia Güller; Tim Beissert; Elena Puccetti; Martin Ruthardt
BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility.
BMC cancer 2006;6():262.
2005: Gesine Bug; Markus Ritter; Barbara Wassmann; Claudia Schoch; Thorsten Heinzel; Kerstin Schwarz; Annette Romanski; Oliver H Kramer; Manuela Kampfmann; Dieter Hoelzer; Andreas Neubauer; Martin Ruthardt; Oliver G Ottmann
Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia.
Cancer 2005;104(12):2717-25.
2005: Elena Puccetti; Xiaomin Zheng; Daria Brambilla; Anita Seshire; Tim Beissert; Simone Boehrer; Heike Nürnberger; Dieter Hoelzer; Oliver G Ottmann; Clara Nervi; Martin Ruthardt
The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.
Cancer research 2005;65(14):6080-8.
2005: Gesine Bug; Hilal Gül; Kerstin Schwarz; Heike Pfeifer; Manuela Kampfmann; Xiaomin Zheng; Tim Beissert; Simone Boehrer; Dieter Hoelzer; Oliver G Ottmann; Martin Ruthardt
Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells.
Cancer research 2005;65(7):2537-41.
2004: Simone Boehrer; Angela Brieger; Simone Schaaf; Natasa Kukoc-Zivojnov; Daniel Nowak; Martin Ruthardt; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann; Kai Uwe Chow
In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis.
Leukemia & lymphoma 2004;45(7):1445-51.
2004: Natasa Kukoc-Zivojnov; Elena Puccetti; Kai Uwe Chow; Marion Bergmann; Martin Ruthardt; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann; Simone Boehrer
Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells.
Experimental hematology 2004;32(7):649-56.
2004: Angela Brieger; Simone Boehrer; Simone Schaaf; Daniel Nowak; Martin Ruthardt; Soo-Zin Kim; Peter Atadja; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann; Kai Uwe Chow
In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors.
Biochemical pharmacology 2004;68(1):85-93.
2004: Elena Puccetti; Martin Ruthardt
Acute promyelocytic leukemia: PML/RARalpha and the leukemic stem cell.
Leukemia 2004;18(7):1169-75.
2004: Xiaomin Zheng; Tim Beissert; Natasa Kukoc-Zivojnov; Elena Puccetti; Joachim Altschmied; Corinna Strolz; Simone Boehrer; Hilal Gul; Orinta Schneider; Oliver G Ottmann; Dieter Hoelzer; Reinhard Henschler; Martin Ruthardt
Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.
Blood 2004;103(9):3535-43.
2004: Chuanbing Zang; Hongyu Liu; Maximilian Posch; Maries Waechter; Margit Facklam; Martin Fenner; Martin Ruthardt; Kurt Possinger; H Phillip Koeffler; Elena Elstner
Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia.
Leukemia research 2004;28(4):387-97.
2004: Annette Romanski; Biserka Bacic; Gesine Bug; Heike Pfeifer; Hilal Gul; Stacy W Remiszewski; Dieter Hoelzer; Peter Atadja; Martin Ruthardt; Oliver G Ottmann
Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia.
Haematologica 2004;89(4):419-26.
2004: Carsten Müller-Tidow; Björn Steffen; Thomas Cauvet; Lara Tickenbrock; Ping Ji; Sven Diederichs; Bülent Sargin; Gabriele Köhler; Matthias Stelljes; Elena Puccetti; Martin Ruthardt; Sven deVos; Scott W Hiebert; H Phillip Koeffler; Wolfgang E Berdel; Hubert Serve
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
Molecular and cellular biology 2004;24(7):2890-904.
2003: Tim Beissert; Elena Puccetti; Andrea Bianchini; Saskia Güller; Simone Boehrer; Dieter Hoelzer; Oliver G Ottmann; Clara Nervi; Martin Ruthardt
Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571.
Blood 2003;102(8):2985-93.
2003: Elena Puccetti; Tim Beissert; Saskia Güller; Jun E Li; Dieter Hoelzer; Oliver G Ottmann; Martin Ruthardt
Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis.
Oncogene 2003;22(44):6900-8.
2003: Kai Uwe Chow; Daniel Nowak; Simone Boehrer; Martin Ruthardt; Andrea Knau; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation.
Biochemical pharmacology 2003;66(5):711-24.
2002: Elena Puccetti; Darja Obradovic; Tim Beissert; Andrea Bianchini; Birgit Washburn; Ferdinando Chiaradonna; Simone Boehrer; Dieter Hoelzer; Oliver G Ottmann; Pier Giuseppe Pelicci; Clara Nervi; Martin Ruthardt
AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor.
Cancer research 2002;62(23):7050-8.
2002: Simone Boehrer; Kai Uwe Chow; Martin Ruthardt; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
Expression and function of prostate-apoptosis-response-gene-4 in lymphatic cells.
Leukemia & lymphoma 2002;43(9):1737-41.
2002: Burkhard Möller; Natasa Kukoc-Zivojnov; Stella Okamgba; Uta Kessler; Elena Puccetti; Oliver G Ottmann; Joachim Peter Kaltwasser; Dieter Hoelzer; Martin Ruthardt
Folinic acid antagonizes methotrexate-induced differentiation of monocyte progenitors.
Rheumatology international 2002;22(2):60-7.
2002: Alexander B Maurer; Christian Wichmann; Alexandra Gross; Hana Kunkel; Thorsten Heinzel; Martin Ruthardt; Bernd Groner; Manuel Grez
The Stat5-RARalpha fusion protein represses transcription and differentiation through interaction with a corepressor complex.
Blood 2002;99(8):2647-52.
2002: Simone Boehrer; Kai Uwe Chow; Florian Beske; Natasa Kukoc-Zivojnov; Elena Puccetti; Martin Ruthardt; Christine Baum; Vivek M Rangnekar; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation.
Cancer research 2002;62(6):1768-75.
2001: Elena Puccetti; B Sennewald; F Fosca-Ferrara; Simone Boehrer; Andrea Bianchini; Dieter Hoelzer; Oliver G Ottmann; Clara Nervi; Martin Ruthardt
Down-stream regions of the POZ-domain influence the interaction of the t(11;17)-associated PLZF/RARalpha fusion protein with the histone-deacetylase recruiting co-repressor complex.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(6):385-92.
2001: Simone Boehrer; Kai Uwe Chow; Elena Puccetti; Martin Ruthardt; S Godzisard; A Krapohl; B Schneider; Dieter Hoelzer; Paris S Mitrou; Vivek M Rangnekar; Eckhart Weidmann
Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(2):103-7.
2000: Elena Puccetti; Saskia Güller; Annette Orleth; Nicole Brüggenolte; Dieter Hoelzer; Oliver G Ottmann; Martin Ruthardt
BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity.
Cancer research 2000;60(13):3409-13.
1999: Thomas Sternsdorf; Elena Puccetti; Kirsten Jensen; Dieter Hoelzer; Hans Will; Oliver G Ottmann; Martin Ruthardt
PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
Molecular and cellular biology 1999;19(7):5170-8.
1998: Clara Nervi; Felicetto Ferrara; Mirco Fanelli; Maria Rita Rippo; Barbara Tomassini; Pier Francesco Ferrucci; Martin Ruthardt; Vania Gelmetti; Carlo Gambacorti-Passerini; Daniela Diverio; Francesco Grignani; Pier Giuseppe Pelicci; Roberto Testi
Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein.
Blood 1998;92(7):2244-51.
1998: Martin Ruthardt; Annette Orleth; L Tomassoni; Elena Puccetti; Daniela Riganelli; Myriam Alcalay; Roberta Mannucci; Ildo Nicoletti; Francesco Grignani; Marta Fagioli; Pier Giuseppe Pelicci
The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies.
Oncogene 1998;16(15):1945-53.
1998: Francesco Grignani; S De Matteis; Clara Nervi; L Tomassoni; Vania Gelmetti; Mario Cioce; Mirco Fanelli; Martin Ruthardt; Felicetto Ferrara; I Zamir; C Seiser; F Grignani; Mitchell Lazar; Saverio Minucci; Pier Giuseppe Pelicci
Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.
Nature 1998;391(6669):815-8.
1997: L Benedetti; A A Levin; bianca maria scicchitano; Francesco Grignani; G Allenby; Daniela Diverio; Francesco Lo Coco; Giuseppe Avvisati; Martin Ruthardt; Sergio Adamo; Pier Giuseppe Pelicci; Clara Nervi
Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells.
Blood 1997;90(3):1175-85.
1997: Martin Ruthardt; U Testa; Clara Nervi; Pier Francesco Ferrucci; F Grignani; Elena Puccetti; Francesco Grignani; Cesare Peschle; Pier Giuseppe Pelicci
Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.
Molecular and cellular biology 1997;17(8):4859-69.