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Gary Ruvkun

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Chemicals & Drugs

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Physiology

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RNA Interference

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Christian G Riedel; Jason A West; John M Asara; Sarah K Bowman; Andrew Dillin; Robert H Dowen; Thomas Heimbucher; Robert E Kingston; Natalia V Kirienko; Guinevere F Lourenco; Gary Ruvkun
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.
Taiowa A Montgomery; Gary Ruvkun
MicroRNAs Visit the ER.
Natalia V Kirienko; Jonah Larkins-Ford; Gary Ruvkun; Carolina Wählby; Daniel R Kirienko; Frederick M Ausubel
Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.

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All Publications

2013: Christian G Riedel; Jason A West; John M Asara; Sarah K Bowman; Andrew Dillin; Robert H Dowen; Thomas Heimbucher; Robert E Kingston; Natalia V Kirienko; Guinevere F Lourenco; Gary Ruvkun
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.
Nature cell biology 2013;15(5):491-501.
2013: Taiowa A Montgomery; Gary Ruvkun
MicroRNAs Visit the ER.
Cell 2013;153(3):511-2.
2013: Natalia V Kirienko; Jonah Larkins-Ford; Gary Ruvkun; Carolina Wählby; Daniel R Kirienko; Frederick M Ausubel
Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.
Cell host & microbe 2013;13(4):406-16.
2013: Zhen Shi; Taiowa A Montgomery; Yan Qi; Gary Ruvkun
High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes.
Genome research 2013;23(3):497-508.
2013: Eyleen J O'Rourke; Petric Kuballa; Ramnik Xavier; Gary Ruvkun
ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.
Genes & development 2013;27(4):429-40.
2013: Yuval Tabach; Keren Yacoby; Or Zuk; Allison C Billi; Mark Borowsky; Brad Chapman; Harrison Gabel; Susana M Garcia; Gabriel D Hayes; Ravi Kamath; John K Kim; Martin A Newman; Gary Ruvkun
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence.
Nature 2013;493(7434):694-8.
2013: Christopher E Carr; Ethan Cascio; Clarissa S Lui; Holli Rowedder; Cyrus Vafadari; Maria T Zuber; Gary Ruvkun
Radiation resistance of biological reagents for in situ life detection.
Astrobiology 2013;13(1):68-78.
2012: Chi Zhang; Gary Ruvkun
New insights into siRNA amplification and RNAi.
RNA biology 2012;9(8):1045-9.
2012: Carolyn M Phillips; Peter C Breen; Taiowa A Montgomery; Gary Ruvkun
MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline.
Genes & development 2012;26(13):1433-44.
2012: Carolina Wählby; Frederick M Ausubel; Annie L Conery; Polina Golland; Javier E Irazoqui; Lee Kamentsky; Zihan H Liu; Vebjorn Ljosa; Eyleen J O'Rourke; Tammy Riklin-Raviv; Gary Ruvkun; Katherine L Sokolnicki; Orane Visvikis; Anne E Carpenter
An image analysis toolbox for high-throughput C. elegans assays.
Nature methods 2012;9(7):714-6.
2012: Chi Zhang; Christopher M Sullivan; James C Carrington; Noah Fahlgren; Sylvia E J Fischer; Susana M D A Garcia; Taiowa A Montgomery; Christian G Riedel; Gary Ruvkun
The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification.
Current biology : CB 2012;22(10):881-90.
2012: Justine A Melo; Gary Ruvkun
Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses.
Cell 2012;149(2):452-66.
2012: Zhen Shi; Gary Ruvkun
The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(12):4568-73.
2012: Robi Tacutu; Arie Budovsky; João Pedro de Magalhães; Vadim Fraifeld; Gary Ruvkun; David E Shore; Sean P Curran
Prediction of C. elegans longevity genes by human and worm longevity networks.
PloS one 2012;7(10):e48282.
2012: David E Shore; Christopher E Carr; Gary Ruvkun
Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways.
PLoS genetics 2012;8(7):e1002792.
2012: Taiowa A Montgomery; Carolyn M Phillips; Young-Soo Rim; Robert H Dowen; Sylvia E J Fischer; Chi Zhang; Gary Ruvkun
PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1.
PLoS genetics 2012;8(4):e1002616.
2012: Xiaoyun Wu; Zhen Shi; Mingxue Cui; Min Han; Gary Ruvkun
Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes.
PLoS genetics 2012;8(3):e1002542.
2011: Sascha Russel; Alison R Frand; Gary Ruvkun
Regulation of the C. elegans molt by pqn-47.
Developmental biology 2011;360(2):297-309.
2011: Sylvia E J Fischer; Alexia Hwang; Taiowa A Montgomery; Peter C Breen; James C Carrington; Noah Fahlgren; Christopher M Sullivan; Chi Zhang; Gary Ruvkun
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.
PLoS genetics 2011;7(11):e1002369.
2011: Gabriel D Hayes; Christian G Riedel; Gary Ruvkun
The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.
Genes & development 2011;25(19):2079-92.
2011: Meng C Wang; Wei Min; Christian W Freudiger; Gary Ruvkun; X Sunney Xie
RNAi screening for fat regulatory genes with SRS microscopy.
Nature methods 2011;8(2):135-8.
2011: Chi Zhang; Taiowa A Montgomery; Harrison W Gabel; Sylvia E J Fischer; Carolyn M Phillips; Noah Fahlgren; Christopher M Sullivan; James C Carrington; Gary Ruvkun
mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1201-8.
2010: Xiaoyun Wu; Gary Ruvkun
Cancer. Germ cell genes and cancer.
Science (New York, N.Y.) 2010;330(6012):1761-2.
2010: Vijaykumar S Meli; Beatriz Osuna; Gary Ruvkun; Alison R Frand
MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.
Molecular biology of the cell 2010;21(10):1648-61.
2009: Eyleen J O'Rourke; Alexander A Soukas; Christopher E Carr; Gary Ruvkun
C. elegans major fats are stored in vesicles distinct from lysosome-related organelles.
Cell metabolism 2009;10(5):430-5.
2009: Sean P Curran; Xiaoyun Wu; Christian G Riedel; Gary Ruvkun
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.
Nature 2009;459(7250):1079-84.
2009: Alexander A Soukas; Elizabeth A Kane; Christopher E Carr; Justine A Melo; Gary Ruvkun
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.
Genes & development 2009;23(4):496-511.
2009: Rebecca A Butcher; Justin R Ragains; Weiqing Li; Gary Ruvkun; Jon Clardy; Ho Yi Mak
Biosynthesis of the Caenorhabditis elegans dauer pheromone.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1875-9.
2009: Paola Sebastiani; Monty Montano; Annibale Puca; Nadia Solovieff; Toshio Kojima; Meng C Wang; Efthymia Melista; Micah Meltzer; Sylvia E J Fischer; Stacy Andersen; Stephen H Hartley; Amanda Sedgewick; Yasumichi Arai; Aviv Bergman; Nir Barzilai; Dellara F Terry; Alberto Riva; Chiara Viviani Anselmi; Alberto Malovini; Aya Kitamoto; Motoji Sawabe; Tomio Arai; Yasuyuki Gondo; Martin H Steinberg; Nobuyoshi Hirose; Gil Atzmon; Gary Ruvkun; Clinton T Baldwin; Thomas T Perls
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.
PloS one 2009;4(12):e8210.
2008: Thomas A Isenbarger; Christopher E Carr; Sarah Stewart Johnson; Michael Finney; George M Church; Walter Gilbert; Maria T Zuber; Gary Ruvkun
The most conserved genome segments for life detection on Earth and other planets.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 2008;38(6):517-33.
2008: Meng C Wang; Eyleen J O'Rourke; Gary Ruvkun
Fat metabolism links germline stem cells and longevity in C. elegans.
Science (New York, N.Y.) 2008;322(5903):957-60.
2008: Gary Ruvkun
The perfect storm of tiny RNAs.
Nature medicine 2008;14(10):1041-5.
2008: Sylvia E J Fischer; Maurice D Butler; Qi Pan; Gary Ruvkun
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.
Nature 2008;455(7212):491-6.
2008: Gary Ruvkun
Tiny RNA: Where do we come from? What are we? Where are we going?
Trends in plant science 2008;13(7):313-6.
2008: Dhaval S Patel; Lily L Fang; Danika K Svy; Gary Ruvkun; Weiqing Li
Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.
Development (Cambridge, England) 2008;135(13):2239-49.
2008: David J Simon; Jon M Madison; Annie L Conery; Katherine L Thompson-Peer; Michael Soskis; Gary Ruvkun; Joshua M Kaplan; John Kim
The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.
Cell 2008;133(5):903-15.
2008: Harrison W Gabel; Gary Ruvkun
The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.
Nature structural & molecular biology 2008;15(5):531-3.
2008: Thomas A Isenbarger; Michael Finney; Carlos Ríos-Velázquez; Jo Handelsman; Gary Ruvkun
Miniprimer PCR, a new lens for viewing the microbial world.
Applied and environmental microbiology 2008;74(3):840-9.
2008: Marsha L Pierce; Michael D Weston; Bernd Fritzsch; Harrison W Gabel; Gary Ruvkun; garrett soukup
MicroRNA-183 family conservation and ciliated neurosensory organ expression.
Evolution & development 2008;10(1):106-13.
2007: Devin H Parry; Jinling Xu; Gary Ruvkun
A whole-genome RNAi Screen for C. elegans miRNA pathway genes.
Current biology : CB 2007;17(23):2013-22.
2007: Andrew V Samuelson; Christopher E Carr; Gary Ruvkun
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
Genes & development 2007;21(22):2976-94.
2007: Nahui Kim; Catherine M Dempsey; Chih-Jen Kuan; Jim V Zoval; Eyleen O'Rourke; Gary Ruvkun; Marc J Madou; Ji Ying Sze
Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans.
Genetics 2007;177(2):835-45.
2007: Sean P Curran; Gary Ruvkun
Lifespan regulation by evolutionarily conserved genes essential for viability.
PLoS genetics 2007;3(4):e56.
2007: Ilya Ruvinsky; Uwe Ohler; Christopher B Burge; Gary Ruvkun
Detection of broadly expressed neuronal genes in C. elegans.
Developmental biology 2007;302(2):617-26.
2007: A V Samuelson; R R Klimczak; D B Thompson; C E Carr; Gary Ruvkun
Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.
Cold Spring Harbor symposia on quantitative biology 2007;72():489-97.
2006: Gabriel D Hayes; Alison R Frand; Gary Ruvkun
The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25.
Development (Cambridge, England) 2006;133(23):4631-41.
2006: Patrick J Hu; Jinling Xu; Gary Ruvkun
Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.
PLoS genetics 2006;2(7):e99.
2006: Gisela M Sandoval; Janet S Duerr; Jonathan Hodgkin; James B Rand; Gary Ruvkun
A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans.
Nature neuroscience 2006;9(5):599-601.
2006: Ho Yi Mak; Laura S Nelson; Michael Basson; Carl D Johnson; Gary Ruvkun
Polygenic control of Caenorhabditis elegans fat storage.
Nature genetics 2006;38(3):363-8.
2006: Thomas F Duchaine; James Wohlschlegel; Scott Kennedy; Yanxia Bei; Darryl Conte; Kaming Pang; Daniel R Brownell; Sandra Harding; Shohei Mitani; Gary Ruvkun; John R Yates; Craig C Mello
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
Cell 2006;124(2):343-54.
2006: Gary Ruvkun
Clarifications on miRNA and cancer.
Science (New York, N.Y.) 2006;311(5757):36-7.
2006: Gabriel D Hayes; Gary Ruvkun
Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs.
Cold Spring Harbor symposia on quantitative biology 2006;71():21-7.
2005: Alison R Frand; Sascha Russel; Gary Ruvkun
Functional genomic analysis of C. elegans molting.
PLoS biology 2005;3(10):e312.
2005: Duo Wang; Scott Kennedy; Darryl Conte; John Kim; Harrison W Gabel; Ravi S Kamath; Craig C Mello; Gary Ruvkun
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.
Nature 2005;436(7050):593-7.
2005: Derek Sieburth; QueeLim Ch'ng; Michael Dybbs; Masoud Tavazoie; Scott Kennedy; Duo Wang; Denis Dupuy; Jean-François Rual; David E Hill; Marc Vidal; Gary Ruvkun; Joshua M Kaplan
Systematic analysis of genes required for synapse structure and function.
Nature 2005;436(7050):510-7.
2005: Benjamin Hamilton; Yuqing Dong; Mami Shindo; Wenyu Liu; Ian Odell; Gary Ruvkun; Siu Sylvia Lee
A systematic RNAi screen for longevity genes in C. elegans.
Genes & development 2005;19(13):1544-55.
2005: John Kim; Harrison W Gabel; Ravi S Kamath; Muneesh Tewari; Amy E Pasquinelli; Jean-François Rual; Scott Kennedy; Michael Dybbs; Nicolas Bertin; Joshua M Kaplan; Marc Vidal; Gary Ruvkun
Functional genomic analysis of RNA interference in C. elegans.
Science (New York, N.Y.) 2005;308(5725):1164-7.
2005: Evgeni Efimenko; Kerry Bubb; Ho Yi Mak; Ted Holzman; Michel R Leroux; Gary Ruvkun; James H Thomas; Peter Swoboda
Analysis of xbx genes in C. elegans.
Development (Cambridge, England) 2005;132(8):1923-34.
2004: Jennifer H Mansfield; Brian D Harfe; Robert Nissen; John Obenauer; Jalagani Srineel; Aadel Chaudhuri; Raphael Farzan-Kashani; Michael Zuker; Amy E Pasquinelli; Gary Ruvkun; Phillip A Sharp; Clifford J Tabin; Michael McManus
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression.
Nature genetics 2004;36(10):1079-83.
2004: Ho Yi Mak; Gary Ruvkun
Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450.
Development (Cambridge, England) 2004;131(8):1777-86.
2004: Muneesh Tewari; Patrick J Hu; Jin Sook Ahn; Nono Ayivi-Guedehoussou; Pierre-Olivier Vidalain; Siming Li; Stuart Milstein; Chris M Armstrong; Mike Boxem; Maurice D Butler; Svetlana Busiguina; Jean-François Rual; Nieves Ibarrola; Sabrina Theresa Chaklos; Nicolas Bertin; Philippe Vaglio; Mark L Edgley; Kevin V King; Patrice S Albert; Jean Vandenhaute; Akhilesh Pandey; Donald L Riddle; Gary Ruvkun; Marc Vidal
Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network.
Molecular cell 2004;13(4):469-82.
2004: Scott Kennedy; Duo Wang; Gary Ruvkun
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.
Nature 2004;427(6975):645-9.
2004: Gary Ruvkun; Bruce Wightman; Ilho Ha
The 20 years it took to recognize the importance of tiny RNAs.
Cell 2004;116(2 Suppl):S93-6, 2 p following S96.
2004: John Kim; Anna M Krichevsky; Yonatan Grad; Gabriel D Hayes; Kenneth S Kosik; George M Church; Gary Ruvkun
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):360-5.
2004: Duo Wang; Gary Ruvkun
Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway.
Cold Spring Harbor symposia on quantitative biology 2004;69():429-31.
2003: Anthony L Komaroff; Gary Ruvkun
Unraveling the secrets of the cell.
Newsweek 2003;142(23):96.
2003: Ilya Ruvinsky; Gary Ruvkun
Functional tests of enhancer conservation between distantly related species.
Development (Cambridge, England) 2003;130(21):5133-42.
2003: Ji Ying Sze; Gary Ruvkun
Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9560-5.
2003: Gudrun Aspöck; Gary Ruvkun; Thomas R Bürglin
The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function.
Development (Cambridge, England) 2003;130(15):3369-78.
2003: Amy E Pasquinelli; Adam McCoy; Eva Jiménez; Emili Saló; Gary Ruvkun; Mark Q Martindale; Jaume Baguñà
Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?
Evolution & development 2003;5(4):372-8.
2003: Arash Bashirullah; Amy E Pasquinelli; Amy A Kiger; Norbert Perrimon; Gary Ruvkun; Carl S Thummel
Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis.
Developmental biology 2003;259(1):1-8.
2003: Danielle A Garsin; Jacinto M Villanueva; Jakob Begun; Dennis H Kim; Costi D Sifri; Stephen B Calderwood; Gary Ruvkun; Frederick M Ausubel
Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.
Science (New York, N.Y.) 2003;300(5627):1921.
2003: Yonatan Grad; John Aach; Gabriel D Hayes; Brenda J Reinhart; George M Church; Gary Ruvkun; John Kim
Computational and experimental identification of C. elegans microRNAs.
Molecular cell 2003;11(5):1253-63.
2003: Siu Sylvia Lee; Scott Kennedy; Andrew C Tolonen; Gary Ruvkun
DAF-16 target genes that control C. elegans life-span and metabolism.
Science (New York, N.Y.) 2003;300(5619):644-7.
2003: Weiqing Li; Scott G Kennedy; Gary Ruvkun
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway.
Genes & development 2003;17(7):844-58.
2003: Victor Ambros; Bonnie Bartel; David P Bartel; Christopher B Burge; James C Carrington; Xuemei Chen; Gideon Dreyfuss; Sean R Eddy; Sam Griffiths-Jones; Mhairi Marshall; Marjori Matzke; Gary Ruvkun; Thomas Tuschl
A uniform system for microRNA annotation.
RNA (New York, N.Y.) 2003;9(3):277-9.
2003: Kaveh Ashrafi; Francesca Y Chang; Jennifer L Watts; Andrew G Fraser; Ravi S Kamath; Julie Ahringer; Gary Ruvkun
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.
Nature 2003;421(6920):268-72.
2003: Gary Ruvkun
The tiny RNA world.
Harvey lectures 2003;99():1-21.
2003: Siu Sylvia Lee; Raymond Y N Lee; Andrew G Fraser; Ravi S Kamath; Julie Ahringer; Gary Ruvkun
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.
Nature genetics 2003;33(1):40-8.
2002: Catherine A Wolkow; Manuel J Muñoz; Donald L Riddle; Gary Ruvkun
Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway.
The Journal of biological chemistry 2002;277(51):49591-7.
2002: Ji Ying Sze; Shenyuan Zhang; Jie Li; Gary Ruvkun
The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.
Development (Cambridge, England) 2002;129(16):3901-11.
2002: Siu Sylvia Lee; Gary Ruvkun
Longevity: don't hold your breath.
Nature 2002;418(6895):287-8.
2002: Amy E Pasquinelli; Gary Ruvkun
Control of developmental timing by micrornas and their targets.
Annual review of cell and developmental biology 2002;18():495-513.
2001: Gary Ruvkun
Molecular biology. Glimpses of a tiny RNA world.
Science (New York, N.Y.) 2001;294(5543):797-9.
2001: Alla Grishok; Amy E Pasquinelli; Darryl Conte; N Li; Susan Parrish; I Ha; David Baillie; Andrew Fire; Gary Ruvkun; Craig C Mello
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.
Cell 2001;106(1):23-34.
2001: C M Cahill; Guri Tzivion; N Nasrin; S Ogg; J Dore; Gary Ruvkun; MC Alexander-Bridges
Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways.
The Journal of biological chemistry 2001;276(16):13402-10.
2001: S B Pierce; M Costa; R Wisotzkey; S Devadhar; S A Homburger; A R Buchman; K C Ferguson; J Heller; D M Platt; A A Pasquinelli; L X Liu; Steve Doberstein; Gary Ruvkun
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
Genes & development 2001;15(6):672-86.
2001: Thomas R Bürglin; Gary Ruvkun
Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6.
Development (Cambridge, England) 2001;128(5):779-90.
2001: Brenda J Reinhart; Gary Ruvkun
Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning.
Genetics 2001;157(1):199-209.
2000: Amy E Pasquinelli; Brenda J Reinhart; FJ Slack; Mark Q Martindale; Mitzi I Kuroda; B Maller; David C Hayward; Eldon E Ball; B Degnan; P Müller; J Spring; A Srinivasan; M Fishman; John R Finnerty; Joseph C Corbo; M Levine; P Leahy; E Davidson; Gary Ruvkun
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.
Nature 2000;408(6808):86-9.
2000: Hiroshi Kagoshima; R Sommer; Brenda J Reinhart; giuseppe cassata; Gary Ruvkun; Thomas R Bürglin
Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal.
Development genes and evolution 2000;210(11):564-9.
2000: C A Wolkow; K D Kimura; M S Lee; Gary Ruvkun
Regulation of C. elegans life-span by insulinlike signaling in the nervous system.
Science (New York, N.Y.) 2000;290(5489):147-50.
2000: N Nasrin; S Ogg; C M Cahill; W Biggs; S Nui; J Dore; Dominica Calvo; Yang Shi; Gary Ruvkun; MC Alexander-Bridges
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10412-7.
2000: FJ Slack; Michael Basson; Z Liu; Victor Ambros; H Robert Horvitz; Gary Ruvkun
The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.
Molecular cell 2000;5(4):659-69.
2000: Brenda J Reinhart; FJ Slack; Michael Basson; Amy E Pasquinelli; JC Bettinger; Ann E Rougvie; H Robert Horvitz; Gary Ruvkun
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.
Nature 2000;403(6772):901-6.
2000: Ji Ying Sze; Martin Victor; C Loer; Yang Shi; Gary Ruvkun
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant.
Nature 2000;403(6769):560-4.
2000: Heidi A Tissenbaum; John M Hawdon; M Perregaux; Peter Hotez; Leonard Guarente; Gary Ruvkun
A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):460-5.
1999: Alvaro Sagasti; Oliver Hobert; ER Troemel; Gary Ruvkun; Cornelia I Bargmann
Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4.
Genes & development 1999;13(14):1794-806.
1999: S Paradis; Michael Ailion; A Toker; James H Thomas; Gary Ruvkun
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
Genes & development 1999;13(11):1438-52.
1999: Oliver Hobert; K Tessmar; Gary Ruvkun
The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons.
Development (Cambridge, England) 1999;126(7):1547-62.
1999: Oliver Hobert; Donald G Moerman; Kathleen A Clark; Mary C Beckerle; Gary Ruvkun
A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans.
The Journal of cell biology 1999;144(1):45-57.
1998: Gary Ruvkun; Oliver Hobert
The taxonomy of developmental control in Caenorhabditis elegans.
Science (New York, N.Y.) 1998;282(5396):2033-41.
1998: Oliver Hobert; Gary Ruvkun
A common theme for LIM homeobox gene function across phylogeny?
The Biological bulletin 1998;195(3):377-80.
1998: FJ Slack; Gary Ruvkun
Heterochronic genes in development and evolution.
The Biological bulletin 1998;195(3):375-6.
1998: S Ogg; Gary Ruvkun
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.
Molecular cell 1998;2(6):887-93.
1998: FJ Slack; Gary Ruvkun
A novel repeat domain that is often associated with RING finger and B-box motifs.
Trends in biochemical sciences 1998;23(12):474-5.
1998: Leonard Guarente; Gary Ruvkun; R Amasino
Aging, life span, and senescence.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11034-6.
1998: S Paradis; Gary Ruvkun
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.
Genes & development 1998;12(16):2488-98.
1998: Oliver Hobert; T D'Alberti; Y Liu; Gary Ruvkun
Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(6):2084-96.
1998: Heidi A Tissenbaum; Gary Ruvkun
An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.
Genetics 1998;148(2):703-17.
1997: S Ogg; S Paradis; S Gottlieb; G I Patterson; L Lee; Heidi A Tissenbaum; Gary Ruvkun
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.
Nature 1997;389(6654):994-9.
1997: G I Patterson; A Koweek; A Wong; Yang Liu; Gary Ruvkun
The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway.
Genes & development 1997;11(20):2679-90.
1997: K D Kimura; Heidi A Tissenbaum; Yang Liu; Gary Ruvkun
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
Science (New York, N.Y.) 1997;277(5328):942-6.
1997: Oliver Hobert; I Mori; Y Yamashita; H Honda; Y Ohshima; Y Liu; Gary Ruvkun
Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene.
Neuron 1997;19(2):345-57.
1997: Ji Ying Sze; Yang Liu; Gary Ruvkun
VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth.
Development (Cambridge, England) 1997;124(6):1159-68.
1997: FJ Slack; Gary Ruvkun
Temporal pattern formation by heterochronic genes.
Annual review of genetics 1997;31():611-34.
1996: I Ha; B Wightman; Gary Ruvkun
A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.
Genes & development 1996;10(23):3041-50.
1996: J Z Morris; Heidi A Tissenbaum; Gary Ruvkun
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.
Nature 1996;382(6591):536-9.
1996: Ralf Baumeister; Y Liu; Gary Ruvkun
Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis.
Genes & development 1996;10(11):1395-410.
1994: D Greenstein; S Hird; Ronald H Plasterk; Y Andachi; Y Kohara; B Wang; M Finney; Gary Ruvkun
Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation.
Genes & development 1994;8(16):1935-48.
1994: S Gottlieb; Gary Ruvkun
daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.
Genetics 1994;137(1):107-20.
1993: B Wightman; I Ha; Gary Ruvkun
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.
Cell 1993;75(5):855-62.
1993: T R Bürglin; Gary Ruvkun
The Caenorhabditis elegans homeobox gene cluster.
Current opinion in genetics & development 1993;3(4):615-20.
1992: D Xue; M Finney; Gary Ruvkun; Martin Chalfie
Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3.
The EMBO journal 1992;11(13):4969-79.
1992: T R Bürglin; Gary Ruvkun
New motif in PBX genes.
Nature genetics 1992;1(5):319-20.
1992: D M Miller; M M Shen; C E Shamu; T R Bürglin; Gary Ruvkun; M L Dubois; M Ghee; L Wilson
C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.
Nature 1992;355(6363):841-5.
1991: P Arasu; B Wightman; Gary Ruvkun
Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.
Genes & development 1991;5(10):1825-33.
1991: B Wightman; T R Bürglin; J Gatto; P Arasu; Gary Ruvkun
Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.
Genes & development 1991;5(10):1813-24.
1991: T R Bürglin; Gary Ruvkun; A Coulson; N C Hawkins; J D McGhee; D Schaller; C Wittmann; Fritz Müller; Robert H Waterston
Nematode homeobox cluster.
Nature 1991;351(6329):703.
1991: Gary Ruvkun; M Finney
Regulation of transcription and cell identity by POU domain proteins.
Cell 1991;64(3):475-8.
1991: Gary Ruvkun; B Wightman; T Bürglin; P Arasu
Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes.
Development (Cambridge, England). Supplement 1991;1():47-54.
1990: M Finney; Gary Ruvkun
The unc-86 gene product couples cell lineage and cell identity in C. elegans.
Cell 1990;63(5):895-905.
1990: Gary Ruvkun; Walter Gilbert; H Robert Horvitz
Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization.
Nucleic acids research 1990;18(4):809-15.
1989: T R Bürglin; M Finney; A Coulson; Gary Ruvkun
Caenorhabditis elegans has scores of homoeobox-containing genes.
Nature 1989;341(6239):239-43.
1989: Gary Ruvkun; J Giusto
The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch.
Nature 1989;338(6213):313-9.
1989: Gary Ruvkun; V Ambros; A Coulson; Robert H Waterston; John E Sulston; H Robert Horvitz
Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14.
Genetics 1989;121(3):501-16.
1988: M Finney; Gary Ruvkun; H Robert Horvitz
The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors.
Cell 1988;55(5):757-69.
1988: Winship Herr; R A Sturm; R G Clerc; L M Corcoran; David Baltimore; Phillip A Sharp; H A Ingraham; M G Rosenfeld; M Finney; Gary Ruvkun
The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.
Genes & development 1988;2(12A):1513-6.