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Gary Ruvkun

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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RNA Interference

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Co-Publications
Name
8
Pasquinelli, Amy
7
Hobert, Oliver
6
Slack, FJ
5
Sze, Ji Ying
5
Reinhart, Brenda
5
Tissenbaum, Heidi
5
Horvitz, Robert
5
Kennedy, Scott
4
Kamath, Ravi
4
Hayes, Gabriel
4
Wang, Duo
4
Ogg, S
4
Lee, Siu Sylvia
4
Mak, Ho Yi
3
Mello, Craig

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Publications

TOP 3
O'Rourke Eyleen J; Soukas Alexander A; Carr Christopher E; Ruvkun Gary
C. elegans major fats are stored in vesicles distinct from lysosome-related organelles.
Curran Sean P; Wu Xiaoyun; Riedel Christian G; Ruvkun Gary
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.
Soukas Alexander A; Kane Elizabeth A; Carr Christopher E; Melo Justine A; Ruvkun Gary
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.

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All Publications

2009: O'Rourke Eyleen J; Soukas Alexander A; Carr Christopher E; Ruvkun Gary
C. elegans major fats are stored in vesicles distinct from lysosome-related organelles.
Cell metabolism 2009;10(5):430-5.
2009: Curran Sean P; Wu Xiaoyun; Riedel Christian G; Ruvkun Gary
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.
Nature 2009;459(7250):1079-84.
2009: Soukas Alexander A; Kane Elizabeth A; Carr Christopher E; Melo Justine A; Ruvkun Gary
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.
Genes & development 2009;23(4):496-511.
2009: Butcher Rebecca A; Ragains Justin R; Li Weiqing; Ruvkun Gary; Clardy Jon; Mak Ho Yi
Biosynthesis of the Caenorhabditis elegans dauer pheromone.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1875-9.
2008: Isenbarger Thomas A; Carr Christopher E; Johnson Sarah Stewart; Finney Michael; Church George M; Gilbert Walter; Zuber Maria T; Ruvkun Gary
The most conserved genome segments for life detection on Earth and other planets.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 2008;38(6):517-33.
2008: Wang Meng C; O'Rourke Eyleen J; Ruvkun Gary
Fat metabolism links germline stem cells and longevity in C. elegans.
Science (New York, N.Y.) 2008;322(5903):957-60.
2008: Ruvkun Gary
The perfect storm of tiny RNAs.
Nature medicine 2008;14(10):1041-5.
2008: Fischer Sylvia E J; Butler Maurice D; Pan Qi; Ruvkun Gary
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.
Nature 2008;455(7212):491-6.
2008: Ruvkun Gary
Tiny RNA: Where do we come from? What are we? Where are we going?
Trends in plant science 2008;13(7):313-6.
2008: Patel Dhaval S; Fang Lily L; Svy Danika K; Ruvkun Gary; Li Weiqing
Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.
Development (Cambridge, England) 2008;135(13):2239-49.
2008: Simon David J; Madison Jon M; Conery Annie L; Thompson-Peer Katherine L; Soskis Michael; Ruvkun Gary B; Kaplan Joshua M; Kim John K
The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.
Cell 2008;133(5):903-15.
2008: Gabel Harrison W; Ruvkun Gary
The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.
Nature structural & molecular biology 2008;15(5):531-3.
2008: Isenbarger Thomas A; Finney Michael; Ríos-Velázquez Carlos; Handelsman Jo; Ruvkun Gary
Miniprimer PCR, a new lens for viewing the microbial world.
Applied and environmental microbiology 2008;74(3):840-9.
2008: Pierce Marsha L; Weston Michael D; Fritzsch Bernd; Gabel Harrison W; Ruvkun Gary; Soukup Garrett A
MicroRNA-183 family conservation and ciliated neurosensory organ expression.
Evolution & development 2008;10(1):106-13.
2007: Parry Devin H; Xu Jinling; Ruvkun Gary
A whole-genome RNAi Screen for C. elegans miRNA pathway genes.
Current biology : CB 2007;17(23):2013-22.
2007: Samuelson Andrew V; Carr Christopher E; Ruvkun Gary
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
Genes & development 2007;21(22):2976-94.
2007: Kim Nahui; Dempsey Catherine M; Kuan Chih-Jen; Zoval Jim V; O'Rourke Eyleen; Ruvkun Gary; Madou Marc J; Sze Ji Y
Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans.
Genetics 2007;177(2):835-45.
2007: Curran Sean P; Ruvkun Gary
Lifespan regulation by evolutionarily conserved genes essential for viability.
PLoS genetics 2007;3(4):e56.
2007: Ruvinsky Ilya; Ohler Uwe; Burge Christopher B; Ruvkun Gary
Detection of broadly expressed neuronal genes in C. elegans.
Developmental biology 2007;302(2):617-26.
2007: Samuelson A V; Klimczak R R; Thompson D B; Carr C E; Ruvkun G
Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.
Cold Spring Harbor symposia on quantitative biology 2007;72():489-97.
2006: Hayes Gabriel D; Frand Alison R; Ruvkun Gary
The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25.
Development (Cambridge, England) 2006;133(23):4631-41.
2006: Hu Patrick J; Xu Jinling; Ruvkun Gary
Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.
PLoS genetics 2006;2(7):e99.
2006: Sandoval Gisela M; Duerr Janet S; Hodgkin Jonathan; Rand James B; Ruvkun Gary
A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans.
Nature neuroscience 2006;9(5):599-601.
2006: Mak Ho Yi; Nelson Laura S; Basson Michael; Johnson Carl D; Ruvkun Gary
Polygenic control of Caenorhabditis elegans fat storage.
Nature genetics 2006;38(3):363-8.
2006: Duchaine Thomas F; Wohlschlegel James A; Kennedy Scott; Bei Yanxia; Conte Darryl; Pang Kaming; Brownell Daniel R; Harding Sandra; Mitani Shohei; Ruvkun Gary; Yates John R; Mello Craig C
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
Cell 2006;124(2):343-54.
2006: Ruvkun Gary
Clarifications on miRNA and cancer.
Science (New York, N.Y.) 2006;311(5757):36-7.
2006: Hayes G D; Ruvkun G
Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs.
Cold Spring Harbor symposia on quantitative biology 2006;71():21-7.
2005: Frand Alison R; Russel Sascha; Ruvkun Gary
Functional genomic analysis of C. elegans molting.
PLoS biology 2005;3(10):e312.
2005: Wang Duo; Kennedy Scott; Conte Darryl; Kim John K; Gabel Harrison W; Kamath Ravi S; Mello Craig C; Ruvkun Gary
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.
Nature 2005;436(7050):593-7.
2005: Sieburth Derek; Ch'ng QueeLim; Dybbs Michael; Tavazoie Masoud; Kennedy Scott; Wang Duo; Dupuy Denis; Rual Jean-François; Hill David E; Vidal Marc; Ruvkun Gary; Kaplan Joshua M
Systematic analysis of genes required for synapse structure and function.
Nature 2005;436(7050):510-7.
2005: Hamilton Benjamin; Dong Yuqing; Shindo Mami; Liu Wenyu; Odell Ian; Ruvkun Gary; Lee Siu Sylvia
A systematic RNAi screen for longevity genes in C. elegans.
Genes & development 2005;19(13):1544-55.
2005: Kim John K; Gabel Harrison W; Kamath Ravi S; Tewari Muneesh; Pasquinelli Amy; Rual Jean-François; Kennedy Scott; Dybbs Michael; Bertin Nicolas; Kaplan Joshua M; Vidal Marc; Ruvkun Gary
Functional genomic analysis of RNA interference in C. elegans.
Science (New York, N.Y.) 2005;308(5725):1164-7.
2005: Efimenko Evgeni; Bubb Kerry; Mak Ho Yi; Holzman Ted; Leroux Michel R; Ruvkun Gary; Thomas James H; Swoboda Peter
Analysis of xbx genes in C. elegans.
Development (Cambridge, England) 2005;132(8):1923-34.
2004: Mansfield Jennifer H; Harfe Brian D; Nissen Robert; Obenauer John; Srineel Jalagani; Chaudhuri Aadel; Farzan-Kashani Raphael; Zuker Michael; Pasquinelli Amy E; Ruvkun Gary; Sharp Phillip A; Tabin Clifford J; McManus Michael T
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression.
Nature genetics 2004;36(10):1079-83.
2004: Mak Ho Yi; Ruvkun Gary
Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450.
Development (Cambridge, England) 2004;131(8):1777-86.
2004: Tewari Muneesh; Hu Patrick J; Ahn Jin Sook; Ayivi-Guedehoussou Nono; Vidalain Pierre-Olivier; Li Siming; Milstein Stuart; Armstrong Chris M; Boxem Mike; Butler Maurice D; Busiguina Svetlana; Rual Jean-François; Ibarrola Nieves; Chaklos Sabrina T; Bertin Nicolas; Vaglio Philippe; Edgley Mark L; King Kevin V; Albert Patrice S; Vandenhaute Jean; Pandey Akhilesh; Riddle Donald L; Ruvkun Gary; Vidal Marc
Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network.
Molecular cell 2004;13(4):469-82.
2004: Kennedy Scott; Wang Duo; Ruvkun Gary
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.
Nature 2004;427(6975):645-9.
2004: Ruvkun Gary; Wightman Bruce; Ha Ilho
The 20 years it took to recognize the importance of tiny RNAs.
Cell 2004;116(2 Suppl):S93-6, 2 p following S96.
2004: Kim John; Krichevsky Anna; Grad Yonatan; Hayes Gabriel D; Kosik Kenneth S; Church George M; Ruvkun Gary
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):360-5.
2004: Wang D; Ruvkun G
Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway.
Cold Spring Harbor symposia on quantitative biology 2004;69():429-31.
2003: Komaroff Anthony L; Ruvkun Gary
Unraveling the secrets of the cell.
Newsweek 2003;142(23):96.
2003: Ruvinsky Ilya; Ruvkun Gary
Functional tests of enhancer conservation between distantly related species.
Development (Cambridge, England) 2003;130(21):5133-42.
2003: Sze Ji Ying; Ruvkun Gary
Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9560-5.
2003: Aspöck Gudrun; Ruvkun Gary; Bürglin Thomas R
The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function.
Development (Cambridge, England) 2003;130(15):3369-78.
2003: Pasquinelli Amy E; McCoy Adam; Jiménez Eva; Saló Emili; Ruvkun Gary; Martindale Mark Q; Baguñà Jaume
Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?
Evolution & development 2003;5(4):372-8.
2003: Bashirullah Arash; Pasquinelli Amy E; Kiger Amy A; Perrimon Norbert; Ruvkun Gary; Thummel Carl S
Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis.
Developmental biology 2003;259(1):1-8.
2003: Garsin Danielle A; Villanueva Jacinto M; Begun Jakob; Kim Dennis H; Sifri Costi D; Calderwood Stephen B; Ruvkun Gary; Ausubel Frederick M
Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.
Science (New York, N.Y.) 2003;300(5627):1921.
2003: Grad Yonatan; Aach John; Hayes Gabriel D; Reinhart Brenda J; Church George M; Ruvkun Gary; Kim John
Computational and experimental identification of C. elegans microRNAs.
Molecular cell 2003;11(5):1253-63.
2003: Lee Siu Sylvia; Kennedy Scott; Tolonen Andrew C; Ruvkun Gary
DAF-16 target genes that control C. elegans life-span and metabolism.
Science (New York, N.Y.) 2003;300(5619):644-7.
2003: Li Weiqing; Kennedy Scott G; Ruvkun Gary
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway.
Genes & development 2003;17(7):844-58.
2003: Ambros Victor; Bartel Bonnie; Bartel David P; Burge Christopher B; Carrington James C; Chen Xuemei; Dreyfuss Gideon; Eddy Sean R; Griffiths-Jones Sam; Marshall Mhairi; Matzke Marjori; Ruvkun Gary; Tuschl Thomas
A uniform system for microRNA annotation.
RNA (New York, N.Y.) 2003;9(3):277-9.
2003: Ashrafi Kaveh; Chang Francesca Y; Watts Jennifer L; Fraser Andrew G; Kamath Ravi S; Ahringer Julie; Ruvkun Gary
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.
Nature 2003;421(6920):268-72.
2003: Lee Siu Sylvia; Lee Raymond Y N; Fraser Andrew G; Kamath Ravi S; Ahringer Julie; Ruvkun Gary
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.
Nature genetics 2003;33(1):40-8.
2003: Ruvkun Gary B
The tiny RNA world.
Harvey lectures 2003;99():1-21.
2002: Wolkow Catherine A; Muñoz Manuel J; Riddle Donald L; Ruvkun Gary
Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway.
The Journal of biological chemistry 2002;277(51):49591-7.
2002: Sze Ji Ying; Zhang Shenyuan; Li Jie; Ruvkun Gary
The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.
Development (Cambridge, England) 2002;129(16):3901-11.
2002: Lee Siu Sylvia; Ruvkun Gary
Longevity: don't hold your breath.
Nature 2002;418(6895):287-8.
2002: Pasquinelli Amy E; Ruvkun Gary
Control of developmental timing by micrornas and their targets.
Annual review of cell and developmental biology 2002;18():495-513.
2001: Ruvkun G
Molecular biology. Glimpses of a tiny RNA world.
Science (New York, N.Y.) 2001;294(5543):797-9.
2001: Grishok A; Pasquinelli A E; Conte D; Li N; Parrish S; Ha I; Baillie D L; Fire A; Ruvkun G; Mello C C
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.
Cell 2001;106(1):23-34.
2001: Cahill C M; Tzivion G; Nasrin N; Ogg S; Dore J; Ruvkun G; Alexander-Bridges M
Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways.
The Journal of biological chemistry 2001;276(16):13402-10.
2001: Pierce S B; Costa M; Wisotzkey R; Devadhar S; Homburger S A; Buchman A R; Ferguson K C; Heller J; Platt D M; Pasquinelli A A; Liu L X; Doberstein S K; Ruvkun G
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
Genes & development 2001;15(6):672-86.
2001: Bürglin T R; Ruvkun G
Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6.
Development (Cambridge, England) 2001;128(5):779-90.
2001: Reinhart B J; Ruvkun G
Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning.
Genetics 2001;157(1):199-209.
2000: Kagoshima H; Sommer R; Reinhart B J; Cassata G; Ruvkun G; Bürglin T R
Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal.
Development genes and evolution 2000;210(11):564-9.
2000: Pasquinelli A E; Reinhart B J; Slack F; Martindale M Q; Kuroda M I; Maller B; Hayward D C; Ball E E; Degnan B; Müller P; Spring J; Srinivasan A; Fishman M; Finnerty J; Corbo J; Levine M; Leahy P; Davidson E; Ruvkun G
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.
Nature 2000;408(6808):86-9.
2000: Wolkow C A; Kimura K D; Lee M S; Ruvkun G
Regulation of C. elegans life-span by insulinlike signaling in the nervous system.
Science (New York, N.Y.) 2000;290(5489):147-50.
2000: Nasrin N; Ogg S; Cahill C M; Biggs W; Nui S; Dore J; Calvo D; Shi Y; Ruvkun G; Alexander-Bridges M C
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10412-7.
2000: Slack F J; Basson M; Liu Z; Ambros V; Horvitz H R; Ruvkun G
The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.
Molecular cell 2000;5(4):659-69.
2000: Reinhart B J; Slack F J; Basson M; Pasquinelli A E; Bettinger J C; Rougvie A E; Horvitz H R; Ruvkun G
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.
Nature 2000;403(6772):901-6.
2000: Sze J Y; Victor M; Loer C; Shi Y; Ruvkun G
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant.
Nature 2000;403(6769):560-4.
2000: Tissenbaum H A; Hawdon J; Perregaux M; Hotez P; Guarente L; Ruvkun G
A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):460-5.
1999: Sagasti A; Hobert O; Troemel E R; Ruvkun G; Bargmann C I
Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4.
Genes & development 1999;13(14):1794-806.
1999: Paradis S; Ailion M; Toker A; Thomas J H; Ruvkun G
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
Genes & development 1999;13(11):1438-52.
1999: Hobert O; Tessmar K; Ruvkun G
The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons.
Development (Cambridge, England) 1999;126(7):1547-62.
1999: Hobert O; Moerman D G; Clark K A; Beckerle M C; Ruvkun G
A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans.
The Journal of cell biology 1999;144(1):45-57.
1998: Hobert O; Ruvkun G
A common theme for LIM homeobox gene function across phylogeny?
The Biological bulletin 1998;195(3):377-80.
1998: Slack F; Ruvkun G
Heterochronic genes in development and evolution.
The Biological bulletin 1998;195(3):375-6.
1998: Ogg S; Ruvkun G
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.
Molecular cell 1998;2(6):887-93.
1998: Slack F J; Ruvkun G
A novel repeat domain that is often associated with RING finger and B-box motifs.
Trends in biochemical sciences 1998;23(12):474-5.
1998: Ruvkun G; Hobert O
The taxonomy of developmental control in Caenorhabditis elegans.
Science (New York, N.Y.) 1998;282(5396):2033-41.
1998: Guarente L; Ruvkun G; Amasino R
Aging, life span, and senescence.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11034-6.
1998: Paradis S; Ruvkun G
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.
Genes & development 1998;12(16):2488-98.
1998: Hobert O; D'Alberti T; Liu Y; Ruvkun G
Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(6):2084-96.
1998: Tissenbaum H A; Ruvkun G
An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.
Genetics 1998;148(2):703-17.
1997: Ogg S; Paradis S; Gottlieb S; Patterson G I; Lee L; Tissenbaum H A; Ruvkun G
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.
Nature 1997;389(6654):994-9.
1997: Patterson G I; Koweek A; Wong A; Liu Y; Ruvkun G
The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway.
Genes & development 1997;11(20):2679-90.
1997: Hobert O; Mori I; Yamashita Y; Honda H; Ohshima Y; Liu Y; Ruvkun G
Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene.
Neuron 1997;19(2):345-57.
1997: Kimura K D; Tissenbaum H A; Liu Y; Ruvkun G
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
Science (New York, N.Y.) 1997;277(5328):942-6.
1997: Sze J Y; Liu Y; Ruvkun G
VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth.
Development (Cambridge, England) 1997;124(6):1159-68.
1997: Slack F; Ruvkun G
Temporal pattern formation by heterochronic genes.
Annual review of genetics 1997;31():611-34.
1996: Ha I; Wightman B; Ruvkun G
A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.
Genes & development 1996;10(23):3041-50.
1996: Morris J Z; Tissenbaum H A; Ruvkun G
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.
Nature 1996;382(6591):536-9.
1996: Baumeister R; Liu Y; Ruvkun G
Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis.
Genes & development 1996;10(11):1395-410.
1994: Greenstein D; Hird S; Plasterk R H; Andachi Y; Kohara Y; Wang B; Finney M; Ruvkun G
Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation.
Genes & development 1994;8(16):1935-48.
1994: Gottlieb S; Ruvkun G
daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.
Genetics 1994;137(1):107-20.
1993: Wightman B; Ha I; Ruvkun G
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.
Cell 1993;75(5):855-62.
1993: Bürglin T R; Ruvkun G
The Caenorhabditis elegans homeobox gene cluster.
Current opinion in genetics & development 1993;3(4):615-20.
1992: Xue D; Finney M; Ruvkun G; Chalfie M
Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3.
The EMBO journal 1992;11(13):4969-79.
1992: Bürglin T R; Ruvkun G
New motif in PBX genes.
Nature genetics 1992;1(5):319-20.
1992: Miller D M; Shen M M; Shamu C E; Bürglin T R; Ruvkun G; Dubois M L; Ghee M; Wilson L
C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.
Nature 1992;355(6363):841-5.
1991: Arasu P; Wightman B; Ruvkun G
Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.
Genes & development 1991;5(10):1825-33.
1991: Wightman B; Bürglin T R; Gatto J; Arasu P; Ruvkun G
Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.
Genes & development 1991;5(10):1813-24.
1991: Bürglin T R; Ruvkun G; Coulson A; Hawkins N C; McGhee J D; Schaller D; Wittmann C; Müller F; Waterston R H
Nematode homeobox cluster.
Nature 1991;351(6329):703.
1991: Ruvkun G; Finney M
Regulation of transcription and cell identity by POU domain proteins.
Cell 1991;64(3):475-8.
1991: Ruvkun G; Wightman B; Bürglin T; Arasu P
Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes.
Development (Cambridge, England). Supplement 1991;1():47-54.
1990: Finney M; Ruvkun G
The unc-86 gene product couples cell lineage and cell identity in C. elegans.
Cell 1990;63(5):895-905.
1990: Ruvkun G; Gilbert W; Horvitz H R
Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization.
Nucleic acids research 1990;18(4):809-15.
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Nature 1989;341(6239):239-43.
1989: Ruvkun G; Giusto J
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The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors.
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