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Alexey Ruzin

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TOP 3
C Hal Jones; Margareta Tuckman; David Keeney; Alexey Ruzin; Patricia A Bradford
Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials.
Alexey Ruzin; Frederick W Immermann; Patricia A Bradford
Real-time PCR and statistical analyses of acrAB and ramA expression in clinical isolates of Klebsiella pneumoniae.
David Keeney; Alexey Ruzin; Fionnuala McAleese; Ellen Murphy; Patricia A Bradford
MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli.

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All Publications

2009: C Hal Jones; Margareta Tuckman; David Keeney; Alexey Ruzin; Patricia A Bradford
Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials.
Antimicrobial agents and chemotherapy 2009;53(2):465-75.
2008: Alexey Ruzin; Frederick W Immermann; Patricia A Bradford
Real-time PCR and statistical analyses of acrAB and ramA expression in clinical isolates of Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy 2008;52(9):3430-2.
2008: David Keeney; Alexey Ruzin; Fionnuala McAleese; Ellen Murphy; Patricia A Bradford
MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli.
The Journal of antimicrobial chemotherapy 2008;61(1):46-53.
2007: Alexey Ruzin; David Keeney; Patricia A Bradford
AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex.
The Journal of antimicrobial chemotherapy 2007;59(5):1001-4.
2007: David Keeney; Alexey Ruzin; Patricia A Bradford
RamA, a transcriptional regulator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae.
Microbial drug resistance (Larchmont, N.Y.) 2007;13(1):1-6.
2006: Matthew W Olson; Alexey Ruzin; Eric Feyfant; Thomas S Rush; John O'Connell; Patricia A Bradford
Functional, biophysical, and structural bases for antibacterial activity of tigecycline.
Antimicrobial agents and chemotherapy 2006;50(6):2156-66.
2005: Fionnuala McAleese; Peter Petersen; Alexey Ruzin; Paul Dunman; Ellen Murphy; Steven Projan; Patricia A Bradford
A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline.
Antimicrobial agents and chemotherapy 2005;49(5):1865-71.
2005: Alexey Ruzin; Melissa A Visalli; David Keeney; Patricia A Bradford
Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy 2005;49(3):1017-22.
2005: Alexey Ruzin; David Keeney; Patricia A Bradford
AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii.
Antimicrobial agents and chemotherapy 2005;49(2):791-3.
2004: Lee D Jennings; Kenneth W Foreman; Thomas S Rush; Desirée H H Tsao; Lidia Mosyak; Scott L Kincaid; Mohani N Sukhdeo; Alan G Sutherland; Weidong Ding; Cynthia Hess Kenny; Chantel L Sabus; Hanlan Liu; Elizabeth G Dushin; Soraya L Moghazeh; Pornpen Labthavikul; Peter J Petersen; Margareta Tuckman; Steven A Haney; Alexey Ruzin
Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction.
Bioorganic & medicinal chemistry 2004;12(19):5115-31.
2004: Lee D Jennings; Kenneth W Foreman; Thomas S Rush; Desirée H H Tsao; Lidia Mosyak; Yuanhong Li; Mohani N Sukhdeo; Weidong Ding; Elizabeth G Dushin; Cynthia Hess Kenny; Soraya L Moghazeh; Peter J Petersen; Alexey Ruzin; Margareta Tuckman; Alan G Sutherland
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction.
Bioorganic & medicinal chemistry letters 2004;14(6):1427-31.
2004: Alexey Ruzin; Guy Singh; Anatoly Severin; Youjun Yang; Russell G Dushin; Alan G Sutherland; Albert A Minnick; Michael Greenstein; Michael K May; David M Shlaes; Patricia A Bradford
Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria.
Antimicrobial agents and chemotherapy 2004;48(3):728-38.
2003: Alan G Sutherland; Juan Alvarez; Weidong Ding; Kenneth W Foreman; Cynthia Hess Kenny; Pornpen Labthavikul; Lidia Mosyak; Peter J Petersen; Thomas S Rush; Alexey Ruzin; Desirée H H Tsao; Karen L Wheless
Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.
Organic & biomolecular chemistry 2003;1(23):4138-40.
2003: Alexey Ruzin; Anatoly Severin; Soraya L Moghazeh; Jerome Etienne; Patricia A Bradford; Steven Projan; David M Shlaes
Inactivation of mprF affects vancomycin susceptibility in Staphylococcus aureus.
Biochimica et biophysica acta 2003;1621(2):117-21.
2002: Alexey Ruzin; Anatoly Severin; Frank Ritacco; Keiko Tabei; Guy Singh; Patricia A Bradford; Marshall M Siegel; Steven Projan; David M Shlaes
Further evidence that a cell wall precursor [C(55)-MurNAc-(peptide)-GlcNAc] serves as an acceptor in a sorting reaction.
Journal of bacteriology 2002;184(8):2141-7.