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Kanaga Sabapathy

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Sabine Pietkiewicz; Kanaga Sabapathy; Dennis Sohn; Wilfried Budach; Susanne Grether-Beck; Roland P Piekorz; Reiner U Jänicke
Oppositional Regulation of Noxa by JNK1 and JNK2 during Apoptosis Induced by Proteasomal Inhibitors.
Ming Kei Lee; Beng Hooi Phang; Wei Wei Teoh; Wei Min Tong; Zhao Qi Wang; Kanaga Sabapathy
Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
Ludovica Ciuffreda; Francesco Cognetti; Ruggero De Maria; Donatella Del Bufalo; Marianna Desideri; Cristina Di Sanza; Adriana Eramo; Italia Falcone; James A McCubrey; Andrea Anichini; Paola Bergamo; Francesca Biagioni; Giovanni Blandino; Ursula Cesta Incani; Augusto Orlandi; Daniela Passeri; Maria Rosaria Ricciardi; Kanaga Sabapathy; Giovanni Sette; Agostino Tafuri; Michele Milella
The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms.

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All Publications

2013: Sabine Pietkiewicz; Kanaga Sabapathy; Dennis Sohn; Wilfried Budach; Susanne Grether-Beck; Roland P Piekorz; Reiner U Jänicke
Oppositional Regulation of Noxa by JNK1 and JNK2 during Apoptosis Induced by Proteasomal Inhibitors.
PloS one 2013;8(4):e61438.
2012: Ming Kei Lee; Beng Hooi Phang; Wei Wei Teoh; Wei Min Tong; Zhao Qi Wang; Kanaga Sabapathy
Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
Cancer cell 2012;22(6):751-64.
2012: Ludovica Ciuffreda; Francesco Cognetti; Ruggero De Maria; Donatella Del Bufalo; Marianna Desideri; Cristina Di Sanza; Adriana Eramo; Italia Falcone; James A McCubrey; Andrea Anichini; Paola Bergamo; Francesca Biagioni; Giovanni Blandino; Ursula Cesta Incani; Augusto Orlandi; Daniela Passeri; Maria Rosaria Ricciardi; Kanaga Sabapathy; Giovanni Sette; Agostino Tafuri; Michele Milella
The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms.
Journal of molecular medicine (Berlin, Germany) 2012;90(6):667-79.
2012: Moorthy Anbalagan; Kanaga Sabapathy
JNK1 and JNK2 play redundant functions in Myc-induced B cell lymphoma formation.
International journal of cancer. Journal international du cancer 2012;130(8):1967-9.
2012: Madhavi P Kadakia; C C de-Fromentel; C Caron de Fromentel; Kanaga Sabapathy
The 5th International p63/p73 Workshop: much more than just tumour suppression.
Cell death and differentiation 2012;19(3):549-50.
2012: Qi-En Wang; Chunhua Han; Kanaga Sabapathy; Bo Zhang; Altaf A Wani
Nucleotide excision repair factor XPC enhances DNA damage-induced apoptosis by downregulating the antiapoptotic short isoform of caspase-2.
Cancer research 2012;72(3):666-75.
2012: Kanaga Sabapathy
Role of the JNK pathway in human diseases.
Progress in molecular biology and translational science 2012;106():145-69.
2011: Alvin Wen Choong Chua; Zhenying Fu; Shu Uin Gan; LIM CHE KANG; Kanaga Sabapathy; Colin Song; Yixin Ting; Toan-Thang Phan
Keloid fibroblasts are more sensitive to Wnt3a treatment in terms of elevated cellular growth and fibronectin expression.
Journal of dermatological science 2011;64(3):199-209.
2011: Byong Hoon Yoo; Laurent Corcos; Mete Erdogan; Kanaga Sabapathy; Takehiko Sasazuki; Senji Shirasawa; Yanfei Wang; Kirill V Rosen
Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.
The Journal of biological chemistry 2011;286(45):38894-903.
2011: Alvin W C Chua; Dongrui Ma; Shu U Gan; Zhenying Fu; Hwan C Han; Colin Song; Kanaga Sabapathy; Toan T Phan
The role of R-spondin2 in keratinocyte proliferation and epidermal thickening in keloid scarring.
The Journal of investigative dermatology 2011;131(3):644-54.
2011: Ming Kei Lee; W M Tong; Z Q Wang; Kanaga Sabapathy
Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo.
Cell death and differentiation 2011;18(2):214-21.
2011: Beng Hooi Phang; Hui Wan Chua; Huihua Li; Yeh Ching Linn; Kanaga Sabapathy
Characterization of novel and uncharacterized p53 SNPs in the Chinese population--intron 2 SNP co-segregates with the common codon 72 polymorphism.
PloS one 2011;6(1):e15320.
2010: Wen Hong Toh; S Y Nam; Kanaga Sabapathy
An essential role for p73 in regulating mitotic cell death.
Cell death and differentiation 2010;17(5):787-800.
2010: Ji-young Song; Hye-Sook Han; Kanaga Sabapathy; Byung-Moo Lee; Eunsil Yu; Jene Choi
Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation.
The Journal of biological chemistry 2010;285(12):9067-76.
2010: Iqbal Dulloo; Ganesan Gopalan; Gerry Melino; Kanaga Sabapathy
The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):4902-7.
2010: Min Xie; Kanaga Sabapathy
Tyrosine 170 is dispensable for c-Jun turnover.
Cellular signalling 2010;22(2):330-7.
2010: Daniel J Gough; Nicole L Messina; Linda Hii; Jodee A Gould; Kanaga Sabapathy; Ashley P S Robertson; Joseph A Trapani; David E Levy; Paul J Hertzog; chris clarke; Ricky Johnstone
Functional crosstalk between type I and II interferon through the regulated expression of STAT1.
PLoS biology 2010;8(4):e1000361.
2010: Hui Wan Chua; Daniel Ng; Serena Choo; San San Lum; Huihua Li; Li Ying Soh; Kanaga Sabapathy; Adeline Seow
Effect of MDM2 SNP309 and p53 codon 72 polymorphisms on lung cancer risk and survival among non-smoking Chinese women in Singapore.
BMC cancer 2010;10():88.
2009: Sonyo Shin; Takayuki Asano; Yixin Yao; Ronghua Zhang; Francois Claret; Murray Korc; Kanaga Sabapathy; David G Menter; James L Abbruzzese; Shrikanth A G Reddy
Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.
Molecular cancer research : MCR 2009;7(5):745-54.
2008: Kanaga Sabapathy; S Y Nam
Defective MHC class I antigen surface expression promotes cellular survival through elevated ER stress and modulation of p53 function.
Cell death and differentiation 2008;15(9):1364-74.
2008: Wen Hong Toh; Emmanuelle Logette; Laurent Corcos; Kanaga Sabapathy
TAp73beta and DNp73beta activate the expression of the pro-survival caspase-2S.
Nucleic acids research 2008;36(13):4498-509.
2008: Ming Kei Lee; Kanaga Sabapathy
The R246S hot-spot p53 mutant exerts dominant-negative effects in embryonic stem cells in vitro and in vivo.
Journal of cell science 2008;121(Pt 11):1899-906.
2008: Sergey Kolomeichuk; David T Terrano; Christopher S Lyle; Kanaga Sabapathy; Timothy C Chambers
Distinct signaling pathways of microtubule inhibitors--vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively.
The FEBS journal 2008;275(8):1889-99.
2008: San San Lum; Hui Wan Chua; Huihua Li; Wen-Feng Li; Nanyan Rao; Jin Wei; Zhiming Shao; Kanaga Sabapathy
MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population.
Carcinogenesis 2008;29(4):754-61.
2008: Beng Hooi Phang; Yeh Ching Linn; Huihua Li; Kanaga Sabapathy
MDM2 SNP309 G allele decreases risk but does not affect onset age or survival of Chinese leukaemia patients.
European journal of cancer (Oxford, England : 1990) 2008;44(5):760-6.
2008: Shin Yuen Nam; Ming Kei Lee; Kanaga Sabapathy
The tumour-suppressor p53 is not required for pancreatic beta cell death during diabetes and upon irradiation.
The Journal of physiology 2008;586(2):407-17.
2007: Ming Kei Lee; Kanaga Sabapathy
Phosphorylation at carboxyl-terminal S373 and S375 residues and 14-3-3 binding are not required for mouse p53 function.
Neoplasia (New York, N.Y.) 2007;9(9):690-8.
2007: Faina Vikhanskaya; Wen Hong Toh; Iqbal Dulloo; Qiang Wu; Lakshmanane Boominathan; Huck-Hui Ng; Karen H Vousden; Kanaga Sabapathy
p73 supports cellular growth through c-Jun-dependent AP-1 transactivation.
Nature cell biology 2007;9(6):698-705.
2007: B H Phang; Kanaga Sabapathy
The codon 72 polymorphism-specific effects of human p53 are absent in mouse cells: implications on generation of mouse models.
Oncogene 2007;26(21):2964-74.
2007: Matthew Whiteman; Siew Hwa Chu; Jia Ling Siau; Peter Rose; Kanaga Sabapathy; Jan-Thorsten Schantz; Nam Sang Cheung; Jeremy P E Spencer; Jeffrey S Armstrong
The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways.
Cellular signalling 2007;19(4):705-14.
2007: K Hettinger; Faina Vikhanskaya; M K Poh; Ming Kei Lee; I de Belle; J-T Zhang; S A G Reddy; Kanaga Sabapathy
c-Jun promotes cellular survival by suppression of PTEN.
Cell death and differentiation 2007;14(2):218-29.
2007: Daniel J Gough; Kanaga Sabapathy; Enoch Yi-No Ko; Helen A Arthur; Robert D Schreiber; Joseph A Trapani; chris clarke; Ricky Johnstone
A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes.
The Journal of biological chemistry 2007;282(2):938-46.
2007: Faina Vikhanskaya; Ming Kei Lee; Marco Mazzoletti; Massimo Broggini; Kanaga Sabapathy
Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.
Nucleic acids research 2007;35(6):2093-104.
2007: Xin-Mei Li; Chen-Chen Li; Shan-Shan Yu; Ju-Tao Chen; Kanaga Sabapathy; Di-Yun Ruan
JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the mice area hippocampal CA1.
The European journal of neuroscience 2007;25(2):391-6.
2006: Wei-Min Tong; Ming Kei Lee; Dominique Galendo; Zhao-Qi Wang; Kanaga Sabapathy
Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice.
International journal of cancer. Journal international du cancer 2006;119(4):745-9.
2006: Mobin M Siddique; Kanaga Sabapathy
Trp53-dependent DNA-repair is affected by the codon 72 polymorphism.
Oncogene 2006;25(25):3489-500.
2006: Linda Strandberg Ihrlund; Emma Hernlund; Kristina Viktorsson; Theocharis Panaretakis; Gabor Barna; Kanaga Sabapathy; Stig Linder; Maria C Shoshan
Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1.
Experimental cell research 2006;312(9):1581-9.
2005: Mobin M Siddique; Chowbay Balram; Lucja Fiszer-Maliszewska; Amit Aggarwal; Angie Tan; Patrick Tan; Khee Chee Soo; Kanaga Sabapathy
Evidence for selective expression of the p53 codon 72 polymorphs: implications in cancer development.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(9):2245-52.
2005: Iqbal Dulloo; Kanaga Sabapathy
Transactivation-dependent and -independent regulation of p73 stability.
The Journal of biological chemistry 2005;280(31):28203-14.
2005: Yuanyu Hu; Xueying Wang; Li Zeng; De-Yu Cai; Kanaga Sabapathy; Stephen P Goff; Eduardo J Firpo; Baojie Li
ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress.
Molecular biology of the cell 2005;16(8):3705-18.
2005: Faina Vikhanskaya; Mobin M Siddique; Ming Kei Lee; Massimo Broggini; Kanaga Sabapathy
Evaluation of the combined effect of p53 codon 72 polymorphism and hotspot mutations in response to anticancer drugs.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(12):4348-56.
2005: Wen Hong Toh; Satoru Kyo; Kanaga Sabapathy
Relief of p53-mediated telomerase suppression by p73.
The Journal of biological chemistry 2005;280(17):17329-38.
2005: Ju-Tao Chen; Da-Hua Lu; Chern-Pang Chia; Di-Yun Ruan; Kanaga Sabapathy; Zhi-Cheng Xiao
Impaired long-term potentiation in c-Jun N-terminal kinase 2-deficient mice.
Journal of neurochemistry 2005;93(2):463-73.
2005: Ming Kei Lee; M Prakash Hande; Kanaga Sabapathy
Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosis.
Journal of cell science 2005;118(Pt 4):819-29.
2004: Kanaga Sabapathy; Erwin F Wagner
JNK2: a negative regulator of cellular proliferation.
Cell cycle (Georgetown, Tex.) 2004;3(12):1520-3.
2004: Wen Hong Toh; Mobin M Siddique; Lakshmanane Boominathan; Kai Wei Lin; Kanaga Sabapathy
c-Jun regulates the stability and activity of the p53 homologue, p73.
The Journal of biological chemistry 2004;279(43):44713-22.
2004: Kanaga Sabapathy; Konrad Hochedlinger; Shin Yuen Nam; anton bauer; Michael Karin; Erwin F Wagner
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation.
Molecular cell 2004;15(5):713-25.
2004: Kai Wei Lin; Shin Yuen Nam; Wen Hong Toh; Iqbal Dulloo; Kanaga Sabapathy
Multiple stress signals induce p73beta accumulation.
Neoplasia (New York, N.Y.) 2004;6(5):546-57.
2004: Geqiang Li; Ying Xiang; Kanaga Sabapathy; Robert H Silverman
An apoptotic signaling pathway in the interferon antiviral response mediated by RNase L and c-Jun NH2-terminal kinase.
The Journal of biological chemistry 2004;279(2):1123-31.
2002: Jean-Pierre David; Kanaga Sabapathy; Oskar Hoffmann; Maria-Helena Idarraga; Erwin F Wagner
JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms.
Journal of cell science 2002;115(Pt 22):4317-25.
2002: Konrad Hochedlinger; Erwin F Wagner; Kanaga Sabapathy
Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis.
Oncogene 2002;21(15):2441-5.
2002: Chowbay Balram; Kanaga Sabapathy; Gao Fei; Kei-Siong Khoo; Edmund J D Lee
Genetic polymorphisms of UDP-glucuronosyltransferase in Asians: UGT1A1*28 is a common allele in Indians.
Pharmacogenetics 2002;12(1):81-3.
2001: A Behrens; Kanaga Sabapathy; ISabella Graef; M Cleary; Gerald R Crabtree; Erwin F Wagner
Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1769-74.
2001: Kanaga Sabapathy; T Kallunki; Jean-Pierre David; ISabella Graef; Michael Karin; Erwin F Wagner
c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation.
The Journal of experimental medicine 2001;193(3):317-28.
1999: Kanaga Sabapathy; W Jochum; Konrad Hochedlinger; L Chang; Michael Karin; Erwin F Wagner
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.
Mechanisms of development 1999;89(1-2):115-24.
1999: Kanaga Sabapathy; Y Hu; T Kallunki; M Schreiber; Jean-Pierre David; W Jochum; Erwin F Wagner; Michael Karin
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.
Current biology : CB 1999;9(3):116-25.