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Hisataka Sabe

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TOP 3
Yuichi Mazaki; Yasuharu Nishimura; Hisataka Sabe
GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production.
Toshi Menju; Eiji Ogawa; Yutaro Otsuka; Hiroshi Date; Haruka Handa; Ari Hashimoto; Shigeru Hashimoto; Yoshinobu Toda; Hiromi Wada; Hisataka Sabe
Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma.
Ari Hashimoto; Shigeru Hashimoto; Mayumi Hirose; Susumu Ishida; Hirokazu Kotani; Toshiaki Manabe; Toshi Menju; Masaki Morishige; Kosuke Noda; Eiji Ogawa; Ryo Ando; Yoshinobu Toda; Hisataka Sabe
GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.

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All Publications

2012: Yuichi Mazaki; Yasuharu Nishimura; Hisataka Sabe
GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production.
Molecular biology of the cell 2012;23(13):2457-67.
2011: Toshi Menju; Eiji Ogawa; Yutaro Otsuka; Hiroshi Date; Haruka Handa; Ari Hashimoto; Shigeru Hashimoto; Yoshinobu Toda; Hiromi Wada; Hisataka Sabe
Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma.
PloS one 2011;6(9):e25301.
2011: Ari Hashimoto; Shigeru Hashimoto; Mayumi Hirose; Susumu Ishida; Hirokazu Kotani; Toshiaki Manabe; Toshi Menju; Masaki Morishige; Kosuke Noda; Eiji Ogawa; Ryo Ando; Yoshinobu Toda; Hisataka Sabe
GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.
PloS one 2011;6(8):e23359.
2009: Hisataka Sabe; Shigeru Hashimoto; Masaki Morishige; Eiji Ogawa; Ari Hashimoto; Jin-Min Nam; Koichi Miura; Hajime Yano; Yasuhito Onodera
The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis.
Traffic (Copenhagen, Denmark) 2009;10(8):982-93.
2009: Koichi Miura; Jin-Min Nam; Chie Kojima; Naoki Mochizuki; Hisataka Sabe
EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts.
Molecular biology of the cell 2009;20(7):1949-59.
2008: Mariko Miyata; Jennifer F Raven; Dionissios Baltzis; Antonis E Koromilas; Hisataka Sabe
IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells.
Cell cycle (Georgetown, Tex.) 2008;7(20):3273-81.
2008: Mariko Hirano; Shigeru Hashimoto; Shigenobu Yonemura; Hisataka Sabe; Shinichi Aizawa
EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition.
The Journal of cell biology 2008;182(6):1217-30.
2008: Shunsuke Kon; Kenji Tanabe; Toshio Watanabe; Hisataka Sabe; Masanobu Satake
Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1.
Experimental cell research 2008;314(7):1415-28.
2008: Hisataka Sabe; Shigeru Hashimoto; Masaki Morishige; Ari Hashimoto; Eiji Ogawa
The EGFR-GEP100-Arf6 pathway in breast cancer: Full invasiveness is not from the inside.
Cell adhesion & migration 2008;2(2):71-3.
2008: Tobias Bauer; Nami Motosugi; Koichi Miura; Hisataka Sabe; Takashi Hiiragi
Dynamic rearrangement of surface proteins is essential for cytokinesis.
Genesis (New York, N.Y. : 2000) 2008;46(3):152-62.
2008: Hajime Yano; Itaru Kobayashi; Yasuhito Onodera; Frédéric Luton; Michel Franco; Yuichi Mazaki; Shigeru Hashimoto; Kazuhiro Iwai; Ze'ev Ronai; Hisataka Sabe
Fbx8 makes Arf6 refractory to function via ubiquitination.
Molecular biology of the cell 2008;19(3):822-32.
2008: Masaki Morishige; Shigeru Hashimoto; Eiji Ogawa; Yoshinobu Toda; Hirokazu Kotani; Mayumi Hirose; Shumei Wei; Ari Hashimoto; Atsuko Yamada; Hajime Yano; Yuichi Mazaki; Hiroshi Kodama; Yoshinori Nio; Toshiaki Manabe; Hiromi Wada; Hidenori Kobayashi; Hisataka Sabe
GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.
Nature cell biology 2008;10(1):85-92.
2007: Jin-Min Nam; Yasuhito Onodera; Yuichi Mazaki; Hiroyuki Miyoshi; Shigeru Hashimoto; Hisataka Sabe
CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.
The EMBO journal 2007;26(3):647-56.
2006: Hisataka Sabe; Yasuhito Onodera; Yuichi Mazaki; Shigeru Hashimoto
ArfGAP family proteins in cell adhesion, migration and tumor invasion.
Current opinion in cell biology 2006;18(5):558-64.
2006: Yuichi Mazaki; Shigeru Hashimoto; Tohru Tsujimura; Masaki Morishige; Ari Hashimoto; Kosuke Aritake; Atsuko Yamada; Jin-Min Nam; Hiroshi Kiyonari; Kazuki Nakao; Hisataka Sabe
Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2.
Nature immunology 2006;7(7):724-31.
2006: Shigeru Hashimoto; Mayumi Hirose; Ari Hashimoto; Masaki Morishige; Atsuko Yamada; Harumi Hosaka; Ken-ichi Akagi; Eiji Ogawa; Chitose Oneyama; Tsutomu Agatsuma; Masato Okada; Hidenori Kobayashi; Hiromi Wada; Hirofumi Nakano; Takahisa Ikegami; Atsushi Nakagawa; Hisataka Sabe
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):7036-41.
2005: Alison J Woods; Theo Kantidakis; Hisataka Sabe; David R Critchley; Jim C Norman
Interaction of paxillin with poly(A)-binding protein 1 and its role in focal adhesion turnover and cell migration.
Molecular and cellular biology 2005;25(9):3763-73.
2005: Yasuhito Onodera; Shigeru Hashimoto; Ari Hashimoto; Masaki Morishige; Yuichi Mazaki; Atsuko Yamada; Eiji Ogawa; Masashi Adachi; Takaki Sakurai; Toshiaki Manabe; Hiromi Wada; Nariaki Matsuura; Hisataka Sabe
Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.
The EMBO journal 2005;24(5):963-73.
2005: Shigeru Hashimoto; Ari Hashimoto; Atsuko Yamada; Yasuhito Onodera; Hisataka Sabe
Assays and properties of the ArfGAPs, AMAP1 and AMAP2, in Arf6 function.
Methods in enzymology 2005;404():216-31.
2004: Chie Kojima; Ari Hashimoto; Izumi Yabuta; Mayumi Hirose; Shigeru Hashimoto; Yasunori Kanaho; Hideki Sumimoto; Takahisa Ikegami; Hisataka Sabe
Regulation of Bin1 SH3 domain binding by phosphoinositides.
The EMBO journal 2004;23(22):4413-22.
2004: Shigeru Hashimoto; Ari Hashimoto; Atsuko Yamada; Chie Kojima; Hiroko Yamamoto; Tomonari Tsutsumi; Mikito Higashi; Akira Mizoguchi; Ryohei Yagi; Hisataka Sabe
A novel mode of action of an ArfGAP, AMAP2/PAG3/Papa lpha, in Arf6 function.
The Journal of biological chemistry 2004;279(36):37677-84.
2004: Larisa Y Romanova; Shigeru Hashimoto; Kee-Oh Chay; Mikhail V Blagosklonny; Hisataka Sabe; J Frederic Mushinski
Phosphorylation of paxillin tyrosines 31 and 118 controls polarization and motility of lymphoid cells and is PMA-sensitive.
Journal of cell science 2004;117(Pt 17):3759-68.
2004: Hajime Yano; Yuichi Mazaki; Kazuo Kurokawa; Steven K Hanks; Michiyuki Matsuda; Hisataka Sabe
Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion.
The Journal of cell biology 2004;166(2):283-95.
2004: Shigeru Hashimoto; Yasuhito Onodera; Ari Hashimoto; Miwa Tanaka; Michinari Hamaguchi; Atsuko Yamada; Hisataka Sabe
Requirement for Arf6 in breast cancer invasive activities.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6647-52.
2004: Hirokazu Watanabe; Tadamichi Shimizu; Jun Nishihira; Riichiro Abe; Toshinori Nakayama; Masaru Taniguchi; Hisataka Sabe; Teruo Ishibashi; Hiroshi Shimizu
Ultraviolet A-induced production of matrix metalloproteinase-1 is mediated by macrophage migration inhibitory factor (MIF) in human dermal fibroblasts.
The Journal of biological chemistry 2004;279(3):1676-83.
2003: Hisataka Sabe
Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion.
Journal of biochemistry 2003;134(4):485-9.
2003: Christine Didier; Limor Broday; Anindita Bhoumik; Sharon Israeli; Shoichi Takahashi; Koh Nakayama; Sheila M Thomas; Christopher E Turner; Scott Henderson; Hisataka Sabe; Ze'ev Ronai
RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization.
Molecular and cellular biology 2003;23(15):5331-45.
2002: Hisataka Sabe
[Ensemble of membrane and cytoskeleton remodelings in cell migration].
Seikagaku. The Journal of Japanese Biochemical Society 2002;74(12):1429-40.
2002: Yurie Yamamoto; Tetsuo Maruyama; Nozomi Sakai; Rei Sakurai; Aki Shimizu; Toshio Hamatani; Hirotaka Masuda; Hiroshi Uchida; Hisataka Sabe; Yasunori Yoshimura
Expression and subcellular distribution of the active form of c-Src tyrosine kinase in differentiating human endometrial stromal cells.
Molecular human reproduction 2002;8(12):1117-24.
2002: Asako Tsubouchi; Junko Sakakura; Ryohei Yagi; Yuichi Mazaki; Erik M Schaefer; Hajime Yano; Hisataka Sabe
Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration.
The Journal of cell biology 2002;159(4):673-83.
2002: Takafumi Oshiro; Shinya Koyama; Shinichiro Sugiyama; Akiko Kondo; Yasuhito Onodera; Toshimasa Asahara; Hisataka Sabe; Akira Kikuchi
Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.
The Journal of biological chemistry 2002;277(41):38618-26.
2002: Alison J Woods; Marnie S Roberts; Jyoti Choudhary; Simon T Barry; Yuichi Mazaki; Hisataka Sabe; Simon J Morley; David R Critchley; Jim C Norman
Paxillin associates with poly(A)-binding protein 1 at the dense endoplasmic reticulum and the leading edge of migrating cells.
The Journal of biological chemistry 2002;277(8):6428-37.
2002: Teruo Iwasaki; Atsushi Nakata; Mutsuko Mukai; Kiyoko Shinkai; Hajime Yano; Hisataka Sabe; Erik M Schaefer; Masaharu Tatsuta; Tohru Tsujimura; Nobuyuki Terada; Eizo Kakishita; Hitoshi Akedo
Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration.
International journal of cancer. Journal international du cancer 2002;97(3):330-5.
2001: Ryohei Yagi; S Ishimaru; Hajime Yano; Ulrike Gaul; Hidesaburo Hanafusa; Hisataka Sabe
A novel muscle LIM-only protein is generated from the paxillin gene locus in Drosophila.
EMBO reports 2001;2(9):814-20.
2001: K Nakamura; Hajime Yano; Erik M Schaefer; Hisataka Sabe
Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies.
Oncogene 2001;20(21):2626-35.
2001: H Uchida; A Kondo; Y Yoshimura; Yuichi Mazaki; Hisataka Sabe
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
The Journal of experimental medicine 2001;193(8):955-66.
2001: Yuichi Mazaki; Shigeru Hashimoto; K Okawa; Asako Tsubouchi; K Nakamura; Ryohei Yagi; Hajime Yano; A Kondo; A Iwamatsu; A Mizoguchi; Hisataka Sabe
An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization.
Molecular biology of the cell 2001;12(3):645-62.
2001: Shigeru Hashimoto; Asako Tsubouchi; Yuichi Mazaki; Hisataka Sabe
Interaction of paxillin with p21-activated Kinase (PAK). Association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3.
The Journal of biological chemistry 2001;276(8):6037-45.
2000: K Nakamura; Hajime Yano; H Uchida; Shigeru Hashimoto; Erik M Schaefer; Hisataka Sabe
Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells.
The Journal of biological chemistry 2000;275(35):27155-64.
2000: Hajime Yano; H Uchida; T Iwasaki; M Mukai; Hitoshi Akedo; K Nakamura; Shigeru Hashimoto; Hisataka Sabe
Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9076-81.
2000: T Kanazawa; S Nakamura; M Momoi; Toshiyuki Yamaji; Hiromu Takematsu; H Yano; Hisataka Sabe; A Yamamoto; Toshisuke Kawasaki; Yasunori Kozutsumi
Inhibition of cytokinesis by a lipid metabolite, psychosine.
The Journal of cell biology 2000;149(4):943-50.
2000: A Kondo; Shigeru Hashimoto; Hajime Yano; K Nagayama; Yuichi Mazaki; Hisataka Sabe
A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration.
Molecular biology of the cell 2000;11(4):1315-27.
2000: A Ito; T R Kataoka; M Watanabe; K Nishiyama; Yuichi Mazaki; Hisataka Sabe; Y Kitamura; H Nojima
A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation.
The EMBO journal 2000;19(4):562-71.
1999: T Hiiragi; Hiroyuki Sasaki; A Nagafuchi; Hisataka Sabe; S C Shen; M Matsuki; K Yamanishi; Shoichiro Tsukita
Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells.
The Journal of biological chemistry 1999;274(48):34148-54.
1999: T Maruyama; Y Yoshimura; Junji Yodoi; Hisataka Sabe
Activation of c-Src kinase is associated with in vitro decidualization of human endometrial stromal cells.
Endocrinology 1999;140(6):2632-6.
1998: Yuichi Mazaki; H Uchida; O Hino; Shigeru Hashimoto; Hisataka Sabe
Paxillin isoforms in mouse. Lack of the gamma isoform and developmentally specific beta isoform expression.
The Journal of biological chemistry 1998;273(35):22435-41.
1997: R Yamaguchi; Yuichi Mazaki; K Hirota; S Hashimoto; Hisataka Sabe
Mitosis specific serine phosphorylation and downregulation of one of the focal adhesion protein, paxillin.
Oncogene 1997;15(15):1753-61.
1997: Hisataka Sabe
[Cell to substratum adhesion signaling].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(10 Suppl):1541-50.
1997: Hisataka Sabe; M Hamaguchi; Hidesaburo Hanafusa
Cell to substratum adhesion is involved in v-Src-induced cellular protein tyrosine phosphorylation: implication for the adhesion-regulated protein tyrosine phosphatase activity.
Oncogene 1997;14(15):1779-88.
1997: Yuichi Mazaki; S Hashimoto; Hisataka Sabe
Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins.
The Journal of biological chemistry 1997;272(11):7437-44.
1994: M Asano; Y Ishida; Hisataka Sabe; M Kondo; K Sugamura; Tasuku Honjo
IL-2 can support growth of CD8+ T cells but not CD4+ T cells of human IL-2 receptor beta-chain transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5373-81.
1994: R Yamaguchi; M Maki; M Hatanaka; Hisataka Sabe
Unphosphorylated and tyrosine-phosphorylated forms of a focal adhesion protein, paxillin, are substrates for calpain II in vitro: implications for the possible involvement of calpain II in mitosis-specific degradation of paxillin.
FEBS letters 1994;356(1):114-6.
1991: Yoshihiko Saito; H Tada; Hisataka Sabe; Tasuku Honjo
Biochemical evidence for a third chain of the interleukin-2 receptor.
The Journal of biological chemistry 1991;266(33):22186-91.
1991: Hisataka Sabe; Junko Kuno; A Koromilas; Y Saito; T Kinashi; M Ueda; T Takamatsu; M Hamaguchi; T Kawakami; Tasuku Honjo
Comparison of protein tyrosine phosphorylation and morphological changes induced by IL-2 and IL-3.
International immunology 1991;3(11):1137-48.
1990: H Kanamori; N Suzuki; H Siomi; T Nosaka; A Sato; Hisataka Sabe; M Hatanaka; Tasuku Honjo
HTLV-1 p27rex stabilizes human interleukin-2 receptor alpha chain mRNA.
The EMBO journal 1990;9(12):4161-6.
1990: Y Saito; T Ogura; M Kamio; Hisataka Sabe; Takashi Uchiyama; Tasuku Honjo
Stepwise formation of the high-affinity complex of the interleukin 2 receptor.
International immunology 1990;2(12):1167-77.
1988: Y Saito; Hisataka Sabe; N Suzuki; S Kondo; T Ogura; Akira Shimizu; Tasuku Honjo
A larger number of L chains (Tac) enhance the association rate of interleukin 2 to the high affinity site of the interleukin 2 receptor.
The Journal of experimental medicine 1988;168(5):1563-72.
1988: Hisataka Sabe; A Tanaka; H Siomi; S Koyasu; S Yonehara; I Yahara; Yutaka Tagaya; K Sugie; Keisuke Teshigawara; Junji Yodoi
Differential effects on expression of IL-2 receptors (p55 and p70) by the HTLV-I pX DNA.
International journal of cancer. Journal international du cancer 1988;41(6):880-5.
1988: T Ogura; M Konishi; N Suzuki; S Kondo; Hisataka Sabe; T Honjo
Molecular mechanism for the formation of the high-affinity complex of interleukin 2 and its receptor.
Molecular biology & medicine 1988;5(2):123-38.
1987: K Tsuboi; K Hirayoshi; K Takeuchi; Hisataka Sabe; Y Shimada; G Ohshio; T Tobe; M Hatanaka
Expression of the c-myc gene in human gastrointestinal malignancies.
Biochemical and biophysical research communications 1987;146(2):699-704.
1987: K Mori; Hisataka Sabe; H Siomi; T Iino; A Tanaka; K Takeuchi; K Hirayoshi; M Hatanaka
Expression of a provirus of human T cell leukaemia virus type I by DNA transfection.
The Journal of general virology 1987;68 ( Pt 2)():499-506.
1986: M Hatanaka; Hisataka Sabe; A Tanaka; K Mori; H Siomi; S Nam; Y Adachi; S Itamura; K Hirayoshi
Genomic expressions of human T-lymphotropic virus (HTLV-I).
AIDS research 1986;2 Suppl 1():S79-85.
1986: T Iino; K Takeuchi; S H Nam; H Siomi; Hisataka Sabe; N Kobayashi; M Hatanaka
Structural analysis of p28 adult T-cell leukaemia-associated antigen.
The Journal of general virology 1986;67 ( Pt 7)():1373-9.
1986: H Kanamori; S Kondo; M Kinoshita; N Suzuki; Y Saito; Hisataka Sabe; N Matsunami; N Ishida; A Shimizu; T Honjo
Interleukin-2 receptor: structure, function, and expression.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():739-49.
1984: Hisataka Sabe; S Kondo; A Shimizu; Yutaka Tagaya; J Yodoi; N Kobayashi; M Hatanaka; N Matsunami; M Maeda; T Noma
Properties of human interleukin-2 receptors expressed on non-lymphoid cells by cDNA transfection.
Molecular biology & medicine 1984;2(6):379-96.
1984: T Nikaido; A Shimizu; N Ishida; Hisataka Sabe; Keisuke Teshigawara; M Maeda; T Uchiyama; J Yodoi; T Honjo
Molecular cloning of cDNA encoding human interleukin-2 receptor.
Nature 1984;311(5987):631-5.