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Pardis Sabeti

Research Profile

Genes & Molecular Sequences

Physiology

Concepts & Ideas

Phenomena

Evolution, Molecular

Disorders

Lassa Fever

Living Beings

Occupations

Genetics, Population

Chemicals & Drugs

Base Sequence

Procedures

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Publications

TOP 3
Sharon R Grossman; Adrian V S Hill; Elinor K. Karlsson; Eric S Lander; Daniel J Park; John L Rinn; Richard A Adegbola; Kristian G Andersen; Rameshwar N K Bamezai; Moran Cabili; Dustin Griesemer; Stephen F Schaffner; Ilya Shlyakhter; Shervin Tabrizi; Fredrik O Vannberg; Sarah Winnicki; Sunny H Wong; Angela Yen; Pardis C Sabeti
Identifying recent adaptations in large-scale genomic data.
Yana G Kamberov; Shilin Li; Daniel E Lieberman; Jason Lohmueller; Junhao Mao; Andrew P McMahon; Bruce A Morgan; Madeline Paymer; Adam Powell; Melissa Burnett; Elizabeth Byrne; Hua Chen; Dorian Fuller; Pascale Gerbault; Elizabeth Hostetter; Yuval Itan; Li Jin; Asa Schachar; Clifford J Tabin; Jingze Tan; Longzhi Tan; Kun Tang; Mark Thomas; Sijia Wang; Abigail Wark; Yajun Yang; Pardis C Sabeti
Modeling recent human evolution in mice by expression of a selected EDAR variant.
Rachel Daniels; Elizabeth J Hamilton; Daniel L Hartl; Amanda K Lukens; Souleymane MBoup; Daouda Ndiaye; Daniel E Neafsey; Danny C Park; Pardis C Sabeti; Stephen F Schaffner; Papa Diogoye Séne; Daria Van Tyne; Hsiao-Han Chang; Dyann F Wirth; Sarah K Volkman
Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal.

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All Publications

2013: Sharon R Grossman; Adrian V S Hill; Elinor K. Karlsson; Eric S Lander; Daniel J Park; John L Rinn; Richard A Adegbola; Kristian G Andersen; Rameshwar N K Bamezai; Moran Cabili; Dustin Griesemer; Stephen F Schaffner; Ilya Shlyakhter; Shervin Tabrizi; Fredrik O Vannberg; Sarah Winnicki; Sunny H Wong; Angela Yen; Pardis C Sabeti
Identifying recent adaptations in large-scale genomic data.
Cell 2013;152(4):703-13.
2013: Yana G Kamberov; Shilin Li; Daniel E Lieberman; Jason Lohmueller; Junhao Mao; Andrew P McMahon; Bruce A Morgan; Madeline Paymer; Adam Powell; Melissa Burnett; Elizabeth Byrne; Hua Chen; Dorian Fuller; Pascale Gerbault; Elizabeth Hostetter; Yuval Itan; Li Jin; Asa Schachar; Clifford J Tabin; Jingze Tan; Longzhi Tan; Kun Tang; Mark Thomas; Sijia Wang; Abigail Wark; Yajun Yang; Pardis C Sabeti
Modeling recent human evolution in mice by expression of a selected EDAR variant.
Cell 2013;152(4):691-702.
2013: Rachel Daniels; Elizabeth J Hamilton; Daniel L Hartl; Amanda K Lukens; Souleymane MBoup; Daouda Ndiaye; Daniel E Neafsey; Danny C Park; Pardis C Sabeti; Stephen F Schaffner; Papa Diogoye Séne; Daria Van Tyne; Hsiao-Han Chang; Dyann F Wirth; Sarah K Volkman
Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal.
PloS one 2013;8(4):e60780.
2012: Stephen K Gire; Christian Happi; Lisa Hensley; Eric S Lander; Joseph B McCormick; Kathleen Rubins; Kristian G Andersen; Zach Bjornson; Robert F Garry; Stephen F Schaffner; Matthew Stremlau; Pardis C Sabeti
Epidemiology. Emerging disease or diagnosis?
Science (New York, N.Y.) 2012;338(6108):750-2.
2012: Hsiao-Han Chang; Kevin J Galinsky; Souleymane MBoup; Daouda Ndiaye; Omar Ndir; Daniel E Neafsey; Daniel J Park; Pardis C Sabeti; Stephen F Schaffner; Sarah K Volkman; Roger C Wiegand; Dyann F Wirth; Daniel L Hartl
Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population.
Molecular biology and evolution 2012;29(11):3427-39.
2012: Daniel J Park; Ulf Ribacke; Pardis C Sabeti; Stephen F Schaffner; Clarissa Valim; Daria Van Tyne; Roger C Wiegand; Dyann F Wirth; Justin S Becker; Hsiao-Han Chang; Kevin Galinsky; Meghan Galligan; Daniel L Hartl; Amanda K Lukens; Souleymane MBoup; Daouda Ndiaye; Daniel E Neafsey; Sarah K Volkman
Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(32):13052-7.
2012: Rachel Daniels; Souleymane MBoup; Jason McKinney; Daouda Ndiaye; Pardis C Sabeti; Papa Diogoye Séne; Sarah K Volkman; Mikeal Wall; Dyann F Wirth
Rapid, field-deployable method for genotyping and discovery of single-nucleotide polymorphisms associated with drug resistance in Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2012;56(6):2976-86.
2012: Meghan A Baker; Nisha Broodie; Sunali D Goonesekera; Oleg Iartchouk; Pardis C Sabeti; Andreas Sandgren; Kristina Wallengren; Douglas Wilson; Megan B Murray
Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to tuberculosis.
The Journal of infectious diseases 2012;205(7):1043-7.
2012: Kristian G Andersen; Steven R Grossman; Christian T Happi; Ilya Shylakhter; Shervin Tabrizi; Pardis C Sabeti
Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2012;367(1590):868-77.
2012: Joseph J Vitti; Sarah A Tishkoff; Mildred K Cho; Pardis C Sabeti
Human evolutionary genomics: ethical and interpretive issues.
Trends in genetics : TIG 2012;28(3):137-45.
2012: Sarah K Volkman; Rachel F Daniels; Mahamadou DIAKITE; Daniel L Hartl; Ousmane A Koita; Donald J Krogstad; Marc A T Muskavitch; Daouda Ndiaye; Daniel E Neafsey; Davis Nwakanma; Daniel J Park; Pardis C Sabeti; Dyann F Wirth
Application of genomics to field investigations of malaria by the international centers of excellence for malaria research.
Acta tropica 2012;121(3):324-32.
2012: Danny A Asogun; Beate Becker-Ziaja; Andrew Dongo; Philomena E Ehiane; Jacqueline Ehimuan; Onikepe Folarin; Martin Gabriel; Stephen Gire; Donatus I Adomeh; Odigie Charles Akhuemokhan; George O Akpede; Sylvester O Alikah; Kristian Andersen; Christian T Happi; Meike Hass; Veritas E Ifeh; Peter Imomeh; Mojeed Momoh; Ekene B Muoebonam; Ikponmwonsa Odia; Maxy A C Odike; Sylvanus A Okogbenin; Peter O Okokhere; Yemisi T Oladapo; Stephan Olschläger; Osagie Osunde; Eric Phelan; Pardis C Sabeti; Eghosasere A Uyigue; Stephan Günther
Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation.
PLoS neglected tropical diseases 2012;6(9):e1839.
2012: Rachel Sealfon; Stephen Calderwood; Crystal Ellis; Stephen Gire; Jason B Harris; Lisa Hensley; Manolis Kellis; Regina C LaRocque; Firdausi Qadri; Edward T Ryan; Pardis C Sabeti
High depth, whole-genome sequencing of cholera isolates from Haiti and the Dominican Republic.
BMC genomics 2012;13():468.
2012: Danny A Milner; Malcolm E Molyneux; Jacqui Montgomery; Daniel E Neafsey; Daniel J Park; David M Rosen; Pardis C Sabeti; Stephen F Schaffner; Karl Boynton Seydel; Terrie E Taylor; Clarissa Valim; Jimmy Vareta; Sarah K Volkman; Roger C Wiegand; Kayla G Barnes; Rachel F Daniels; Simon J Glover; Steve Kamiza; Amanda K Lukens; Nira C Mahesh; Daria Van Tyne; Dyann F Wirth
Human cerebral malaria and Plasmodium falciparum genotypes in Malawi.
Malaria journal 2012;11():35.
2011: Luis Branco; Mbalu Fonnie; Kristian G Andersen; James J Bangura; Matt L Boisen; Donald S Grant; Jessica N Grove; Lee A Henderson; Lina M Moses; Ivana J Muncy; Vanessa N Raabe; James E Robinson; Pardis C Sabeti; John S Schieffellin; Eleina M Zaitsev; Robert F Garry
Lassa hemorrhagic fever in a late term pregnancy from northern Sierra Leone with a positive maternal outcome: case report.
Virology journal 2011;8():404.
2011: Kate M Broadbent; Manoj T Duraisingh; Daniel Park; Ulf Ribacke; Pardis C Sabeti; Jennifer S Sims; Daria Van Tyne; Sarah K Volkman; Dyann Wirth; Ashley R Wolf; John L Rinn
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs.
Genome biology 2011;12(6):R56.
2010: Ann Demogines; Alysia M East; Ji-Hoon Lee; Sharon R Grossman; Pardis C Sabeti; Tanya T Paull; Sara L Sawyer
Ancient and recent adaptive evolution of primate non-homologous end joining genes.
PLoS genetics 2010;6(10):e1001169.
2010: Steven R Grossman; Ilya Shylakhter; Elinor K Karlsson; Elizabeth H Byrne; Shannon Morales; Gabriel Frieden; Elizabeth Hostetter; Elaine Angelino; Manuel Garber; Or Zuk; Eric S Lander; Stephen F Schaffner; Ilya Shlyakhter; Pardis C Sabeti
A composite of multiple signals distinguishes causal variants in regions of positive selection.
Science (New York, N.Y.) 2010;327(5967):883-6.
2009: Taane G Clark; Andrew E Fry; Sarah Auburn; Susana Campino; Mahamadou DIAKITE; Angela Green; Anna Richardson; Yik Y Teo; Kerrin S Small; Jonathan Wilson; Muminatou Jallow; Fatoumatta Sisay-Joof; Margaret Pinder; Pardis C Sabeti; Dominic P Kwiatkowski; Kirk Rockett
Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility.
European journal of human genetics : EJHG 2009;17(8):1080-5.
2009: Andrew E Fry; Anita Ghansa; Kerrin S Small; Alejandro Palma; Sarah Auburn; Mahamadou DIAKITE; Angela Green; Susana Campino; Yik Y Teo; Taane G Clark; Anna E Jeffreys; Jonathan Wilson; Muminatou Jallow; Fatoumatta Sisay-Joof; Margaret Pinder; Michael J Griffiths; Norbert Peshu; Thomas N Williams; Charles Newton; Kevin Marsh; Malcolm E Molyneux; Terrie E Taylor; Kwadwo Koram; Abraham R Oduro; William O Rogers; Kirk Rockett; Pardis C Sabeti; Dominic P Kwiatkowski
Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes.
Human molecular genetics 2009;18(14):2683-92.
2009: Regina C LaRocque; Pardis C Sabeti; Priya Duggal; Fahima Chowdhury; Ashraful I Khan; L M Lebrun; Jason B Harris; Edward T Ryan; Firdausi Qadri; Stephen B Calderwood
A variant in long palate, lung and nasal epithelium clone 1 is associated with cholera in a Bangladeshi population.
Genes and immunity 2009;10(3):267-72.
2008: Daniel E Neafsey; Stephen F Schaffner; Sarah K Volkman; Daniel Park; Philip Montgomery; Danny A Milner; Amanda Lukens; David Rosen; Rachel Daniels; Nathan Houde; Joseph F Cortese; Erin Tyndall; Casey Gates; Nicole Stange-Thomann; Ousmane Sarr; Daouda Ndiaye; Omar Ndir; Soulyemane Mboup; Marcelo U Ferreira; Sandra do Lago Moraes; Aditya P Dash; Chetan E Chitnis; Roger C Wiegand; Daniel L Hartl; Bruce W Birren; Eric S Lander; Pardis C Sabeti; Dyann F Wirth
Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.
Genome biology 2008;9(12):R171.
2008: Rachel Daniels; Sarah K Volkman; Danny A Milner; Nira Mahesh; Daniel E Neafsey; Daniel J Park; David Rosen; Elaine Angelino; Pardis C Sabeti; Dyann F Wirth; Roger C Wiegand
A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking.
Malaria journal 2008;7():223.
2007: Michelle M A Fernando; Christine R Stevens; Pardis C Sabeti; Emily C Walsh; Alasdair J M McWhinnie; Anila Shah; Todd Green; John D Rioux; Timothy J Vyse
Identification of two independent risk factors for lupus within the MHC in United Kingdom families.
PLoS genetics 2007;3(11):e192.
2007: Fuli Yu; R Sean Hill; Stephen F Schaffner; Pardis C Sabeti; Eric T Wang; Andre A Mignault; Russell J Ferland; Robert K Moyzis; Christopher Walsh; David Reich
Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".
Science (New York, N.Y.) 2007;316(5823):370.
2007: Vincent Butty; Matt Roy; Pardis C Sabeti; Whitney Besse; Christophe Benoist; Diane Mathis
Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(2):570-5.
2007: Sarah K Volkman; Pardis C Sabeti; David DeCaprio; Daniel E Neafsey; Stephen F Schaffner; Danny A Milner; Johanna Daily; Ousmane Sarr; Daouda Ndiaye; Omar Ndir; Souleymane MBoup; Manoj T Duraisingh; Amanda Lukens; Alan Derr; Nicole Stange-Thomann; Skye Waggoner; Robert Onofrio; Liuda Ziaugra; Evan Mauceli; Sante Gnerre; David B Jaffe; Joanne Zainoun; Roger C Wiegand; Bruce Birren; Daniel L Hartl; James E Galagan; Eric S Lander; Dyann F Wirth
A genome-wide map of diversity in Plasmodium falciparum.
Nature genetics 2007;39(1):113-9.
2006: Paul I W de Bakker; Gil McVean; Pardis C Sabeti; Marcos M Miretti; Todd Green; Jonathan Marchini; Xiayi Ke; Alienke J Monsuur; Pamela Whittaker; Marcos Delgado; Jonathan Morrison; Angela Richardson; Emily C Walsh; Xiaojiang Gao; Luana Galver; John Hart; David A Hafler; Margaret Pericak-Vance; John A Todd; Mark J Daly; John Trowsdale; Cisca Wijmenga; Timothy J Vyse; Stephan Beck; Sarah Shaw Murray; Mary Carrington; Simon Gregory; Panos Deloukas; John D Rioux
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.
Nature genetics 2006;38(10):1166-72.
2006: Pardis C Sabeti; Stephen F Schaffner; Ben Fry; Jason Lohmueller; Patrick Varilly; O Shamovsky; A Palma; Tarjei S Mikkelsen; David Altshuler; Eric S Lander
Positive natural selection in the human lineage.
Science (New York, N.Y.) 2006;312(5780):1614-20.
2006: Yali Xue; Allan Daly; Bryndis Yngvadottir; Mengning Liu; Graham Coop; Yuseob Kim; Pardis C Sabeti; Yuan Chen; Jim Stalker; Elizabeth Huckle; John Burton; Steven Leonard; Jane Rogers; Chris Tyler-Smith
Spread of an inactive form of caspase-12 in humans is due to recent positive selection.
American journal of human genetics 2006;78(4):659-70.
2006: Etienne Patin; Luis B Barreiro; Pardis C Sabeti; Frédéric Austerlitz; Francesca Luca; Antti Sajantila; Doron M Behar; Ornella Semino; Anavaj Sakuntabhai; Nicole Guiso; Brigitte Gicquel; Ken McElreavey; Rosalind M Harding; Evelyne Heyer; Lluis Quintana-Murci
Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.
American journal of human genetics 2006;78(3):423-36.
2006: Emily C Walsh; Pardis C Sabeti; Holli B Hutcheson; Ben Fry; Stephen F Schaffner; Paul I W de Bakker; Patrick Varilly; Alejandro A Palma; Jessica Roy; Richard Cooper; Cheryl Winkler; Yi Zeng; Guy de The; Eric S Lander; Stephen O'Brien; David Altshuler
Searching for signals of evolutionary selection in 168 genes related to immune function.
Human genetics 2006;119(1-2):92-102.
2006: Steven A McCarroll; Tracy N Hadnott; George H Perry; Pardis C Sabeti; Michael C Zody; Jeffrey C Barrett; Stephanie Dallaire; Stacey B Gabriel; Charles Lee; Mark J Daly; David Altshuler
Common deletion polymorphisms in the human genome.
Nature genetics 2006;38(1):86-92.
2005: Pardis C Sabeti; Emily Walsh; Stephen F Schaffner; Patrick Varilly; Ben Fry; Holli B Hutcheson; Michael Cullen; Tarjei S Mikkelsen; Jessica Roy; Nick Patterson; Richard Cooper; David Reich; David Altshuler; Stephen O'Brien; Eric S Lander
The case for selection at CCR5-Delta32.
PLoS biology 2005;3(11):e378.
2005: Fuli Yu; Pardis C Sabeti; Paul Hardenbol; Qing Fu; Ben Fry; Xiuhua Lu; Sy Ghose; Richard Vega; Ag Perez; Shiran Pasternak; Suzanne M Leal; Thomas D Willis; David L Nelson; John W Belmont; Richard A Gibbs
Positive selection of a pre-expansion CAG repeat of the human SCA2 gene.
PLoS genetics 2005;1(3):e41.
2005: Nicole Soranzo; Bernd Bufe; Pardis C Sabeti; James Wilson; Michael E Weale; Richard Marguerie; Wolfgang Meyerhof; David B Goldstein
Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16.
Current biology : CB 2005;15(14):1257-65.
2004: Giorgio Sirugo; Elizabeth A Schaefer; Alieu Mendy; Beryl West; Robin Bailey; Gijs Walraven; Pardis C Sabeti; Fabio Macciardi; Laura A Zonta
Is G6PD A- deficiency associated with recurrent stillbirths in The Gambia?
American journal of medical genetics. Part A 2004;128A(1):104-5.
2004: Todd Bersaglieri; Pardis C Sabeti; Nick Patterson; Trisha Vanderploeg; Stephen F Schaffner; Jared A Drake; Matthew Rhodes; David E Reich; Joel N Hirschhorn
Genetic signatures of strong recent positive selection at the lactase gene.
American journal of human genetics 2004;74(6):1111-20.
2003: Sarah J Campbell; Pardis C Sabeti; Katherine Fielding; Jackson Sillah; Boubacar Bah; Per Gustafson; Kebba Manneh; Ida Maria Lisse; Giorgio Sirugo; Richard Bellamy; Steve Bennett; Peter Aaby; Keith P W J McAdam; Oumou Bah-Sow; Christian Lienhardt; Adrian V S Hill
Variants of the CD40 ligand gene are not associated with increased susceptibility to tuberculosis in West Africa.
Immunogenetics 2003;55(7):502-7.
2002: Pardis C Sabeti; David E Reich; John M Higgins; Haninah Z P Levine; Daniel J Richter; Stephen F Schaffner; Stacey B Gabriel; Jill Platko; Nick Patterson; Gavin J McDonald; Hans C Ackerman; Sarah J Campbell; David Altshuler; Richard Cooper; Dominic Kwiatkowski; Ryk Ward; Eric S Lander
Detecting recent positive selection in the human genome from haplotype structure.
Nature 2002;419(6909):832-7.
2002: Pardis C Sabeti; Stanley Usen; S Farhadian; Muminatou Jallow; T Doherty; Melanie J Newport; Margaret Pinder; Ryk Ward; Dominic Kwiatkowski
CD40L association with protection from severe malaria.
Genes and immunity 2002;3(5):286-91.
2001: David E Reich; M Cargill; S Bolk; J Ireland; Pardis C Sabeti; Daniel J Richter; T Lavery; R Kouyoumjian; S F Farhadian; Ryk Ward; Eric S Lander
Linkage disequilibrium in the human genome.
Nature 2001;411(6834):199-204.