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Helen Sabzevari

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Shinji Takai; Benedetto Farsaci; Helen Sabzevari; Jeffrey Schlom; John W Greiner
Distinct effects of saracatinib on memory CD8+ T cell differentiation.
Noriko Sato; Helen Sabzevari; Song Fu; Wei Ju; Michael N Petrus; Richard N Bamford; Thomas A Waldmann; Yutaka Tagaya
Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα.
Benedetto Farsaci; Helen Sabzevari; Jack P Higgins; Maria Giovanna Di Bari; Shinji Takai; Jeffrey Schlom; James W Hodge
Effect of a small molecule BCL-2 inhibitor on immune function and use with a recombinant vaccine.

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All Publications

2012: Shinji Takai; Benedetto Farsaci; Helen Sabzevari; Jeffrey Schlom; John W Greiner
Distinct effects of saracatinib on memory CD8+ T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(9):4323-33.
2011: Noriko Sato; Helen Sabzevari; Song Fu; Wei Ju; Michael N Petrus; Richard N Bamford; Thomas A Waldmann; Yutaka Tagaya
Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα.
Blood 2011;117(15):4032-40.
2010: Benedetto Farsaci; Helen Sabzevari; Jack P Higgins; Maria Giovanna Di Bari; Shinji Takai; Jeffrey Schlom; James W Hodge
Effect of a small molecule BCL-2 inhibitor on immune function and use with a recombinant vaccine.
International journal of cancer. Journal international du cancer 2010;127(7):1603-13.
2009: Maria Giovanna di Bari; M E Christine Lutsiak; Shinji Takai; Sven Mostböck; Benedetto Farsaci; Roshanak Tolouei Semnani; Lalage M Wakefield; Jeffrey Schlom; Helen Sabzevari
TGF-beta modulates the functionality of tumor-infiltrating CD8+ T cells through effects on TCR signaling and Spred1 expression.
Cancer immunology, immunotherapy : CII 2009;58(11):1809-18.
2009: Mary Litzinger; Kenneth A Foon; Helen Sabzevari; Kwong-Yok Tsang; Jeffrey Schlom; Claudia Palena
Chronic lymphocytic leukemia (CLL) cells genetically modified to express B7-1, ICAM-1, and LFA-3 confer APC capacity to T cells from CLL patients.
Cancer immunology, immunotherapy : CII 2009;58(6):955-65.
2009: Cinzia Remondo; Vittore Cereda; Sven Mostböck; Helen Sabzevari; Alex Franzusoff; Jeffrey Schlom; Kwong-Y Tsang
Human dendritic cell maturation and activation by a heat-killed recombinant yeast (Saccharomyces cerevisiae) vector encoding carcinoembryonic antigen.
Vaccine 2009;27(7):987-94.
2008: Roshanak Tolouei Semnani; Priyanka Goel Venugopal; Cynthia A Leifer; Sven Mostböck; Helen Sabzevari; Thomas B Nutman
Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites.
Blood 2008;112(4):1290-8.
2008: Jeong-Seok Nam; Masaki Terabe; Mizuko Mamura; Mi-Jin Kang; Helen Chae; Christina Stuelten; Ethan Kohn; Binwu Tang; Helen Sabzevari; Miriam R Anver; Scott Lawrence; David Danielpour; Scott Lonning; Jay A Berzofsky; Lalage M Wakefield
An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments.
Cancer research 2008;68(10):3835-43.
2008: M E Christine Lutsiak; Yutaka Tagaya; Anthony J Adams; Jeffrey Schlom; Helen Sabzevari
Tumor-induced impairment of TCR signaling results in compromised functionality of tumor-infiltrating regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):5871-81.
2008: Sven Mostböck; M E Christine Lutsiak; Diane E Milenic; Kwamena Baidoo; Jeffrey Schlom; Helen Sabzevari
IL-2/anti-IL-2 antibody complex enhances vaccine-mediated antigen-specific CD8+ T cell responses and increases the ratio of effector/memory CD8+ T cells to regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):5118-29.
2008: Rebecca E Sadun; Wen-En Hsu; Nan Zhang; Yu-Chih Nien; Scott A Bergfeld; Helen Sabzevari; M E Christine Lutsiak; Leslie Khawli; Peisheng Hu; Alan L Epstein
Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2008;31(3):235-45.
2008: Michael B Bernstein; Mala Chakraborty; Elizabeth K Wansley; Zhimin Guo; Alex Franzusoff; Sven Mostböck; Helen Sabzevari; Jeffrey Schlom; James W Hodge
Recombinant Saccharomyces cerevisiae (yeast-CEA) as a potent activator of murine dendritic cells.
Vaccine 2008;26(4):509-21.
2008: Peisheng Hu; Robyn S Arias; Rebecca E Sadun; Yu-Chih Nien; Nan Zhang; Helen Sabzevari; M E Christine Lutsiak; Leslie A Khawli; Alan L Epstein
Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):579-88.
2007: Sven Mostböck; Silvia Vidal; Jeffrey Schlom; Helen Sabzevari
Enhanced levels of costimulation lead to reduced effector/memory CD8+ T cell functionality.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3524-34.
2007: Sven Mostböck; Marta Catalfamo; Yutaka Tagaya; Jeffrey Schlom; Helen Sabzevari
Acquisition of antigen presentasome (APS), an MHC/costimulatory complex, is a checkpoint of memory T-cell homeostasis.
Blood 2007;109(6):2488-95.
2006: James W Hodge; John W Greiner; Kwong-Yok Tsang; Helen Sabzevari; Chie Kudo-Saito; Douglas W Grosenbach; James L Gulley; Philip M Arlen; John L Marshall; Dennis Panicali; Jeffrey Schlom
Costimulatory molecules as adjuvants for immunotherapy.
Frontiers in bioscience : a journal and virtual library 2006;11():788-803.
2005: Jun Zhou; Yutaka Tagaya; Roshanak Tolouei-Semnani; Jeffrey Schlom; Helen Sabzevari
Physiological relevance of antigen presentasome (APS), an acquired MHC/costimulatory complex, in the sustained activation of CD4+ T cells in the absence of APCs.
Blood 2005;105(8):3238-46.
2005: M E Christine Lutsiak; Roshanak Tolouei Semnani; Roberto De Pascalis; Syed V S Kashmiri; Jeffrey Schlom; Helen Sabzevari
Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide.
Blood 2005;105(7):2862-8.
2005: Hisataka Kobayashi; Sigrid Dubois; Noriko Sato; Helen Sabzevari; Yoshio Sakai; Thomas Waldmann; Yutaka Tagaya
Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance.
Blood 2005;105(2):721-7.
2004: Dale C Slavin-Chiorini; Marta Catalfamo; Chie Kudo-Saito; James W Hodge; Jeffrey Schlom; Helen Sabzevari
Amplification of the lytic potential of effector/memory CD8+ cells by vector-based enhancement of ICAM-1 (CD54) in target cells: implications for intratumoral vaccine therapy.
Cancer gene therapy 2004;11(10):665-80.
2004: Jeffrey Schlom; Claudia Palena; John W Greiner; Kwong-Yok Tsang; Douglas W Grosenbach; Helen Sabzevari; James L Gulley; Philip M Arlen; Erik S Kass; James W Hodge
Combinatorial vaccine strategies and the use of molecular arrays to characterize T-cell activation.
Developments in biologicals 2004;116():27-47.
2003: Roshanak Tolouei Semnani; Anne Y Liu; Helen Sabzevari; Joseph Kubofcik; Jun Zhou; Julia Gilden; Thomas B Nutman
Brugia malayi microfilariae induce cell death in human dendritic cells, inhibit their ability to make IL-12 and IL-10, and reduce their capacity to activate CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1950-60.
2003: Jeffrey Schlom; Helen Sabzevari; Douglas W Grosenbach; James W Hodge
A triad of costimulatory molecules synergize to amplify T-cell activation in both vector-based and vector-infected dendritic cell vaccines.
Artificial cells, blood substitutes, and immobilization biotechnology 2003;31(2):193-228.
2002: Zohreh Tatari-Calderone; Roshanak Tolouei Semnani; Thomas B Nutman; Jeffrey Schlom; Helen Sabzevari
Acquisition of CD80 by human T cells at early stages of activation: functional involvement of CD80 acquisition in T cell to T cell interaction.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6162-9.
2002: Urban J Scheuring; Helen Sabzevari; Argyrios N Theofilopoulos
Proliferative arrest and cell cycle regulation in CD8(+)CD28(-) versus CD8(+)CD28(+) T cells.
Human immunology 2002;63(11):1000-9.
2001: Roshanak Tolouei Semnani; Helen Sabzevari; R Iyer; Thomas B Nutman
Filarial antigens impair the function of human dendritic cells during differentiation.
Infection and immunity 2001;69(9):5813-22.
2001: James W Hodge; Douglas W Grosenbach; Ariel Rad; Mariateresa Giuliano; Helen Sabzevari; Jeffrey Schlom
Enhancing the potency of peptide-pulsed antigen presenting cells by vector-driven hyperexpression of a triad of costimulatory molecules.
Vaccine 2001;19(25-26):3552-67.
2001: Helen Sabzevari; J Kantor; A Jaigirdar; Yutaka Tagaya; M Naramura; J Hodge; J Bernon; Jeffrey Schlom
Acquisition of CD80 (B7-1) by T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2505-13.
2000: J Marks-Konczalik; Sigrid Dubois; J M Losi; Helen Sabzevari; N Yamada; Lionel Feigenbaum; Thomas Waldmann; Yutaka Tagaya
IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11445-50.
2000: James W Hodge; Ariel Rad; Douglas W Grosenbach; Helen Sabzevari; Alicia Gómez Yafal; Linda Gritz; Jeffrey Schlom
Enhanced activation of T cells by dendritic cells engineered to hyperexpress a triad of costimulatory molecules.
Journal of the National Cancer Institute 2000;92(15):1228-39.
1999: James W Hodge; Helen Sabzevari; Alicia Gómez Yafal; Linda Gritz; MG Lorenz; Jeffrey Schlom
A triad of costimulatory molecules synergize to amplify T-cell activation.
Cancer research 1999;59(22):5800-7.
1999: Urban J Scheuring; Helen Sabzevari; Jacques Corbeil; Argyrios N Theofilopoulos
Differential expression profiles of apoptosis-affecting genes in HIV-infected cell lines and patient T cells.
AIDS (London, England) 1999;13(2):167-75.
1997: Helen Sabzevari; S Propp; Dwight H Kono; Argyrios N Theofilopoulos
G1 arrest and high expression of cyclin kinase and apoptosis inhibitors in accumulated activated/memory phenotype CD4+ cells of older lupus mice.
European journal of immunology 1997;27(8):1901-10.
1994: Helen Sabzevari; S D Gillies; Barbara M Mueller; J D Pancook; Ralph A Reisfeld
A recombinant antibody-interleukin 2 fusion protein suppresses growth of hepatic human neuroblastoma metastases in severe combined immunodeficiency mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9626-30.
1993: Helen Sabzevari; Ralph A Reisfeld
Human cytotoxic T-cells suppress the growth of spontaneous melanoma metastases in SCID/hu mice.
Cancer research 1993;53(20):4933-7.
1993: Anthony M P Montgomery; Helen Sabzevari; Ralph A Reisfeld
Production and regulation of gelatinase B by human T-cells.
Biochimica et biophysica acta 1993;1176(3):265-8.