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James Sacchettini

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Concepts & Ideas

Procedures

X-Ray Crystallography

Genes & Molecular Sequences

Amino Acid Sequence

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Chemicals & Drugs

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Co-Publications
Name
32
Jacobs Jr., William R.
21
Ioerger, Thomas
14
Scapin, Giovanna
10
Kremer, Laurent
10
Kelly, Jeffery
10
Palaninathan, Satheesh
9
Young, AC
9
Vilchèze, Catherine
8
David, Fidock
8
Besra, Gurdyal
8
Gokulan, Kuppan
8
Grubmeyer, Charles
6
Freundlich, Joel
6
Nathenson, Stanley
6
Klabunde, Thomas

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Publications

TOP 3
Sun Qingan; Kuty Gabriel F; Arockiasamy Arulandu; Xu Min; Young Ry; Sacchettini James C
Regulation of a muralytic enzyme by dynamic membrane topology.
Swanson Stephanie; Gokulan Kuppan; Sacchettini James C
KasA, another brick in the mycobacterial cell wall.
Ioerger Thomas R; Sacchettini James C
Structural genomics approach to drug discovery for Mycobacterium tuberculosis.

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All Publications

2009: Sun Qingan; Kuty Gabriel F; Arockiasamy Arulandu; Xu Min; Young Ry; Sacchettini James C
Regulation of a muralytic enzyme by dynamic membrane topology.
Nature structural & molecular biology 2009;16(11):1192-4.
2009: Swanson Stephanie; Gokulan Kuppan; Sacchettini James C
KasA, another brick in the mycobacterial cell wall.
Structure (London, England : 1993) 2009;17(7):914-5.
2009: Ioerger Thomas R; Sacchettini James C
Structural genomics approach to drug discovery for Mycobacterium tuberculosis.
Current opinion in microbiology 2009;12(3):318-25.
2009: Barkan Daniel; Liu Zhen; Sacchettini James C; Glickman Michael S
Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.
Chemistry & biology 2009;16(5):499-509.
2009: Freundlich Joel S; Wang Feng; Vilchèze Catherine; Gulten Gulcin; Langley Robert; Schiehser Guy A; Jacobus David P; Jacobs William R; Sacchettini James C
Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis.
ChemMedChem 2009;4(2):241-8.
2009: Ioerger Thomas R; Koo Sunwoo; No Eun-Gyu; Chen Xiaohua; Larsen Michelle H; Jacobs William R; Pillay Manormoney; Sturm A Willem; Sacchettini James C
Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.
PloS one 2009;4(11):e7778.
2009: Palaninathan Satheesh K; Mohamedmohaideen Nilofar N; Orlandini Elisabetta; Ortore Gabriella; Nencetti Susanna; Lapucci Annalina; Rossello Armando; Freundlich Joel S; Sacchettini James C
Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis.
PloS one 2009;4(7):e6290.
2008: Yu Min; Kumar T R Santha; Nkrumah Louis J; Coppi Alida; Retzlaff Silke; Li Celeste D; Kelly Brendan J; Moura Pedro A; Lakshmanan Viswanathan; Freundlich Joel S; Valderramos Juan-Carlos; Vilcheze Catherine; Siedner Mark; Tsai Jennifer H-C; Falkard Brie; Sidhu Amar Bir Singh; Purcell Lisa A; Gratraud Paul; Kremer Laurent; Waters Andrew P; Schiehser Guy; Jacobus David P; Janse Chris J; Ager Arba; Jacobs William R; Sacchettini James C; Heussler Volker; Sinnis Photini; Fidock David A
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Cell host & microbe 2008;4(6):567-78.
2008: Reddy Manchi C M; Kuppan Gokulan; Shetty Nishant D; Owen Joshua L; Ioerger Thomas R; Sacchettini James C
Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein science : a publication of the Protein Society 2008;17(12):2134-44.
2008: Cho Yoonsang; Ioerger Thomas R; Sacchettini James C
Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening.
Journal of medicinal chemistry 2008;51(19):5984-92.
2008: Palaninathan Satheesh K; Mohamedmohaideen Nilofar N; Snee William C; Kelly Jeffery W; Sacchettini James C
Structural insight into pH-induced conformational changes within the native human transthyretin tetramer.
Journal of molecular biology 2008;382(5):1157-67.
2008: Vilchèze Catherine; Av-Gay Yossef; Attarian Rodgoun; Liu Zhen; Hazbón Manzour H; Colangeli Roberto; Chen Bing; Liu Weijun; Alland David; Sacchettini James C; Jacobs William R
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.
Molecular microbiology 2008;69(5):1316-29.
2008: Dey Sanghamitra; Burton Rodney L; Grant Gregory A; Sacchettini James C
Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase.
Biochemistry 2008;47(32):8271-82.
2008: Chinnaswamy Sreedhar; Yarbrough Ian; Palaninathan Satheesh; Kumar C T Ranjith; Vijayaraghavan Vinodhini; Demeler Borries; Lemon Stanley M; Sacchettini James C; Kao C Cheng
A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase.
The Journal of biological chemistry 2008;283(29):20535-46.
2008: Javid-Majd Farah; Yang Dong; Ioerger Thomas R; Sacchettini James C
The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 6):627-35.
2008: Mohamedmohaideen Nilofar N; Palaninathan Satheesh K; Morin Paul M; Williams Brad J; Braunstein Miriam; Tichy Shane E; Locker Joseph; Russell David H; Jacobs William R; Sacchettini James C
Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis.
Biochemistry 2008;47(23):6092-102.
2008: Bhardwaj Kanchan; Palaninathan Satheesh; Alcantara Joanna Maria Ortiz; Yi Lillian Li; Guarino Linda; Sacchettini James C; Kao C Cheng
Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15.
The Journal of biological chemistry 2008;283(6):3655-64.
2008: Sacchettini James C; Rubin Eric J; Freundlich Joel S
Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis.
Nature reviews. Microbiology 2008;6(1):41-52.
2008: Reddy Manchi C M; Gokulan Kuppan; Jacobs William R; Ioerger Thomas R; Sacchettini James C
Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response.
Protein science : a publication of the Protein Society 2008;17(1):159-70.
2008: Zwart Peter H; Afonine Pavel V; Grosse-Kunstleve Ralf W; Hung Li-Wei; Ioerger Thomas R; McCoy Airlie J; McKee Erik; Moriarty Nigel W; Read Randy J; Sacchettini James C; Sauter Nicholas K; Storoni Laurent C; Terwilliger Thomas C; Adams Paul D
Automated structure solution with the PHENIX suite.
Methods in molecular biology (Clifton, N.J.) 2008;426():419-35.
2007: Kang Hyojeung; Bhardwaj Kanchan; Li Yi; Palaninathan Satheesh; Sacchettini James; Guarino Linda; Leibowitz Julian L; Kao C Cheng
Biochemical and genetic analyses of murine hepatitis virus Nsp15 endoribonuclease.
Journal of virology 2007;81(24):13587-97.
2007: Reddy Manchi C M; Palaninathan Satheesh K; Shetty Nishant D; Owen Joshua L; Watson Misty D; Sacchettini James C
High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme.
The Journal of biological chemistry 2007;282(37):27334-42.
2007: Freundlich Joel S; Wang Feng; Tsai Han-Chun; Kuo Mack; Shieh Hong-Ming; Anderson John W; Nkrumah Louis J; Valderramos Juan-Carlos; Yu Min; Kumar T R Santha; Valderramos Stephanie G; Jacobs William R; Schiehser Guy A; Jacobus David P; Fidock David A; Sacchettini James C
X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
The Journal of biological chemistry 2007;282(35):25436-44.
2007: Tsai Chi-Lin; Gokulan Kuppan; Sobrado Pablo; Sacchettini James C; Fitzpatrick Paul F
Mechanistic and structural studies of H373Q flavocytochrome b2: effects of mutating the active site base.
Biochemistry 2007;46(26):7844-51.
2007: Cai Xiaomin; Lorraine Fuller A; McDougald Larry R; Tan Xiangshi; Cai Jianping; Wang Feng; Sacchettini James C; Zhu Guan
Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa).
FEMS microbiology letters 2007;272(2):238-44.
2007: Nicola George; Smith Colin A; Lucumi Edinson; Kuo Mack R; Karagyozov Luchezar; Fidock David A; Sacchettini James C; Abagyan Ruben
Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening.
Biochemical and biophysical research communications 2007;358(3):686-91.
2007: Murillo A C; Li H Y; Alber T; Baker E N; Berger J M; Cherney L T; Cherney M M; Cho Yoon Song; Eisenberg D; Garen C R; Goulding C W; Hung L W; Ioerger T R; Jacobs W R; James M N G; Kim C; Krieger I; Lott J S; Sankaranarayanan R; Segelke B W; Terwilliger T C; Wang F; Wang S; Sacchettini J C
High throughput crystallography of TB drug targets.
Infectious disorders drug targets 2007;7(2):127-39.
2007: Dey Sanghamitra; Hu Zhiqin; Xu Xiao Lan; Sacchettini James C; Grant Gregory A
The effect of hinge mutations on effector binding and domain rotation in Escherichia coli D-3-phosphoglycerate dehydrogenase.
The Journal of biological chemistry 2007;282(25):18418-26.
2007: Wang Feng; Langley Robert; Gulten Gulcin; Wang Lei; Sacchettini James C
Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence.
Chemistry & biology 2007;14(5):543-51.
2007: Ramesh Arati; Savva Christos G; Holzenburg Andreas; Sacchettini James C
Crystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA binding activity.
The Journal of biological chemistry 2007;282(20):14960-7.
2007: Sridharan Sudharsan; Wang Lei; Brown Alistair K; Dover Lynn G; Kremer Laurent; Besra Gurdyal S; Sacchettini James C
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).
Journal of molecular biology 2007;366(2):469-80.
2007: Gopal Kreshna; McKee Erik; Romo Tod; Pai Reetal; Smith Jacob; Sacchettini James; Ioerger Thomas
Crystallographic protein model-building on the web.
Bioinformatics (Oxford, England) 2007;23(3):375-7.
2007: Wang Feng; Langley Robert; Gulten Gulcin; Dover Lynn G; Besra Gurdyal S; Jacobs William R; Sacchettini James C
Mechanism of thioamide drug action against tuberculosis and leprosy.
The Journal of experimental medicine 2007;204(1):73-8.
2007: Liu Tong; Ramesh Arati; Ma Zhen; Ward Sarah K; Zhang Limei; George Graham N; Talaat Adel M; Sacchettini James C; Giedroc David P
CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.
Nature chemical biology 2007;3(1):60-8.
2007: Sidhu Amar Bir Singh; Sun Qingan; Nkrumah Louis J; Dunne Michael W; Sacchettini James C; Fidock David A
In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin.
The Journal of biological chemistry 2007;282(4):2494-504.
2007: Alahari Anuradha; Trivelli Xavier; Guérardel Yann; Dover Lynn G; Besra Gurdyal S; Sacchettini James C; Reynolds Robert C; Coxon Geoffrey D; Kremer Laurent
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.
PloS one 2007;2(12):e1343.
2006: Romo Tod D; Sacchettini James C; Ioerger Thomas R
Improving amino-acid identification, fit and C(alpha) prediction using the Simplex method in automated model building.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 11):1401-6.
2006: Pai Reetal; Sacchettini James; Ioerger Thomas
Identifying non-crystallographic symmetry in protein electron-density maps: a feature-based approach.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 9):1012-21.
2006: Vilchèze Catherine; Wang Feng; Arai Masayoshi; Hazbón Manzour Hernando; Colangeli Roberto; Kremer Laurent; Weisbrod Torin R; Alland David; Sacchettini James C; Jacobs William R
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.
Nature medicine 2006;12(9):1027-9.
2006: Gould Ty A; van de Langemheen Helmus; Muñoz-Elías Ernesto J; McKinney John D; Sacchettini James C
Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis.
Molecular microbiology 2006;61(4):940-7.
2006: Wang Feng; Cassidy Craig; Sacchettini James C
Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics.
Antimicrobial agents and chemotherapy 2006;50(8):2762-71.
2006: Gaffin Robert D; Gokulan Kuppan; Sacchettini James C; Hewett Timothy E; Klevitsky Raisa; Robbins Jeffrey; Sarin Vandana; Zawieja David C; Meininger Gerald A; Muthuchamy Mariappan
Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics.
American journal of physiology. Heart and circulatory physiology 2006;291(2):H552-63.
2006: Owens Róisín M; Hsu Fong Fu; VanderVen Brian C; Purdy Georgiana E; Hesteande Elizabeth; Giannakas Peter; Sacchettini James C; McKinney John D; Hill Preston J; Belisle John T; Butcher Barbara A; Pethe Kevin; Russell David G
M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs).
Molecular microbiology 2006;60(5):1152-63.
2006: Zhao Xiangbo; Yu Hong; Yu Shengwei; Wang Feng; Sacchettini James C; Magliozzo Richard S
Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant.
Biochemistry 2006;45(13):4131-40.
2006: Freundlich Joel S; Yu Min; Lucumi Edinson; Kuo Mack; Tsai Han-Chun; Valderramos Juan-Carlos; Karagyozov Luchezar; Jacobs William R; Schiehser Guy A; Fidock David A; Jacobus David P; Sacchettini James C
Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.
Bioorganic & medicinal chemistry letters 2006;16(8):2163-9.
2006: Morbidoni Hector R; Vilchèze Catherine; Kremer Laurent; Bittman Robert; Sacchettini James C; Jacobs William R
Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids.
Chemistry & biology 2006;13(3):297-307.
2005: Trevino Saul R; Gokulan Kuppan; Newsom Stephanie; Thurlkill Richard L; Shaw Kevin L; Mitkevich Vladimir A; Makarov Alexander A; Sacchettini James C; Scholtz J Martin; Pace C Nick
Asp79 makes a large, unfavorable contribution to the stability of RNase Sa.
Journal of molecular biology 2005;354(4):967-78.
2005: Freundlich Joel S; Anderson John W; Sarantakis Dimitri; Shieh Hong-Ming; Yu Min; Valderramos Juan-Carlos; Lucumi Edinson; Kuo Mack; Jacobs William R; Fidock David A; Schiehser Guy A; Jacobus David P; Sacchettini James C
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.
Bioorganic & medicinal chemistry letters 2005;15(23):5247-52.
2005: Paricharttanakul N Monique; Ye Sheng; Menefee Ann L; Javid-Majd Farah; Sacchettini James C; Reinhart Gregory D
Kinetic and structural characterization of phosphofructokinase from Lactobacillus bulgaricus.
Biochemistry 2005;44(46):15280-6.
2005: Bhatt Apoorva; Kremer Laurent; Dai Annie Z; Sacchettini James C; Jacobs William R
Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.
Journal of bacteriology 2005;187(22):7596-606.
2005: McKee E W; Kanbi L D; Childs K L; Grosse-Kunstleve R W; Adams P D; Sacchettini J C; Ioerger T R
FINDMOL: automated identification of macromolecules in electron-density maps.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 11):1514-20.
2005: Brown Alistair K; Sridharan Sudharsan; Kremer Laurent; Lindenberg Sandra; Dover Lynn G; Sacchettini James C; Besra Gurdyal S
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
The Journal of biological chemistry 2005;280(37):32539-47.
2005: Gao Tiyu; Zhang Xiaofan; Xia Youlin; Cho Yoonsang; Sacchettini James C; Golden Susan S; Liwang Andy C
1H, 13C and 15N chemical shift assignments of the C-terminal, 133-residue pseudo-receiver domain of circadian input kinase (CikA) in Synechococcus elongatus.
Journal of biomolecular NMR 2005;32(3):259.
2005: Gokulan Kuppan; Khare Sangeeta; Ronning Donald R; Linthicum Scott D; Sacchettini James C; Rupp Bernhard
Cocrystal structures of NC6.8 Fab identify key interactions for high potency sweetener recognition: implications for the design of synthetic sweeteners.
Biochemistry 2005;44(29):9889-98.
2005: Gopal Kreshna; Romo Tod D; Sacchettini James C; Ioerger Thomas R
Determining relevant features to recognize electron density patterns in x-ray protein crystallography.
Journal of bioinformatics and computational biology 2005;3(3):645-76.
2005: Dey Sanghamitra; Hu Zhiqin; Xu Xiao Lan; Sacchettini James C; Grant Gregory A
D-3-Phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes.
The Journal of biological chemistry 2005;280(15):14884-91.
2005: Dey Sanghamitra; Grant Gregory A; Sacchettini James C
Crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits.
The Journal of biological chemistry 2005;280(15):14892-9.
2005: Colangeli Roberto; Helb Danica; Sridharan Sudharsan; Sun Jingchuan; Varma-Basil Mandira; Hazbón Manzour Hernando; Harbacheuski Ryhor; Megjugorac Nicholas J; Jacobs William R; Holzenburg Andreas; Sacchettini James C; Alland David
The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol.
Molecular microbiology 2005;55(6):1829-40.
2005: Johnson Steven M; Petrassi H Michael; Palaninathan Satheesh K; Mohamedmohaideen Nilofar N; Purkey Hans E; Nichols Christopher; Chiang Kyle P; Walkup Traci; Sacchettini James C; Sharpless K Barry; Kelly Jeffery W
Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
Journal of medicinal chemistry 2005;48(5):1576-87.
2005: Lee Jeongeun Eun; Kim Kyounghyun; Sacchettini James C; Smith Clare V; Safe Stephen
DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.
The Journal of biological chemistry 2005;280(10):8819-30.
2005: Sridharan Sudharsan; Razvi Abbas; Scholtz J Martin; Sacchettini James C
The HPr proteins from the thermophile Bacillus stearothermophilus can form domain-swapped dimers.
Journal of molecular biology 2005;346(3):919-31.
2005: Vilchèze Catherine; Weisbrod Torin R; Chen Bing; Kremer Laurent; Hazbón Manzour H; Wang Feng; Alland David; Sacchettini James C; Jacobs William R
Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.
Antimicrobial agents and chemotherapy 2005;49(2):708-20.
2005: Xu Min; Arulandu Arockiasamy; Struck Douglas K; Swanson Stephanie; Sacchettini James C; Young Ry
Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme.
Science (New York, N.Y.) 2005;307(5706):113-7.
2004: Purkey Hans E; Palaninathan Satheesh K; Kent Kathleen C; Smith Craig; Safe Stephen H; Sacchettini James C; Kelly Jeffery W
Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity.
Chemistry & biology 2004;11(12):1719-28.
2004: Ronning Donald R; Vissa Varalakshmi; Besra Gurdyal S; Belisle John T; Sacchettini James C
Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity.
The Journal of biological chemistry 2004;279(35):36771-7.
2004: Ye Sheng; Vakonakis Ioannis; Ioerger Thomas R; LiWang Andy C; Sacchettini James C
Crystal structure of circadian clock protein KaiA from Synechococcus elongatus.
The Journal of biological chemistry 2004;279(19):20511-8.
2004: Gaffin Robert D; Gokulan Kuppan; Sacchettini James C; Hewett Timothy; Klevitsky Raisa; Robbins Jeffrey; Muthuchamy Mariappan
Charged residue changes in the carboxy-terminus of alpha-tropomyosin alter mouse cardiac muscle contractility.
The Journal of physiology 2004;556(Pt 2):531-43.
2004: Adamski-Werner Sara L; Palaninathan Satheesh K; Sacchettini James C; Kelly Jeffery W
Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
Journal of medicinal chemistry 2004;47(2):355-74.
2004: Adams Paul D; Gopal Kreshna; Grosse-Kunstleve Ralf W; Hung Li-Wei; Ioerger Thomas R; McCoy Airlie J; Moriarty Nigel W; Pai Reetal K; Read Randy J; Romo Tod D; Sacchettini James C; Sauter Nicholas K; Storoni Laurent C; Terwilliger Thomas C
Recent developments in the PHENIX software for automated crystallographic structure determination.
Journal of synchrotron radiation 2004;11(Pt 1):53-5.
2004: Gopal Kreshna; Romo Tod D; Sacchettini James C; Ioerger Thomas R
Weighting features to recognize 3D patterns of electron density in X-ray protein crystallography.
Proceedings / IEEE Computational Systems Bioinformatics Conference, CSB. IEEE Computational Systems Bioinformatics Conference 2004;():255-65.
2004: Smith Clare V; Sharma Vivek; Sacchettini James C
TB drug discovery: addressing issues of persistence and resistance.
Tuberculosis (Edinburgh, Scotland) 2004;84(1-2):45-55.
2003: Smith Clare V; Sacchettini James C
Mycobacterium tuberculosis: a model system for structural genomics.
Current opinion in structural biology 2003;13(6):658-64.
2003: Reddy Vinod; Swanson Stanley M; Segelke Brent; Kantardjieff Katherine A; Sacchettini James C; Rupp Bernhard
Effective electron-density map improvement and structure validation on a Linux multi-CPU web cluster: The TB Structural Genomics Consortium Bias Removal Web Service.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2200-10.
2003: Green Nora S; Palaninathan Satheesh K; Sacchettini James C; Kelly Jeffery W
Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization.
Journal of the American Chemical Society 2003;125(44):13404-14.
2003: Eicken Christoph; Pennella Mario A; Chen Xiaohua; Koshlap Karl M; VanZile Michael L; Sacchettini James C; Giedroc David P
A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins.
Journal of molecular biology 2003;333(4):683-95.
2003: Takano Kazufumi; Scholtz J Martin; Sacchettini James C; Pace C Nick
The contribution of polar group burial to protein stability is strongly context-dependent.
The Journal of biological chemistry 2003;278(34):31790-5.
2003: Razavi Hossein; Palaninathan Satheesh K; Powers Evan T; Wiseman R Luke; Purkey Hans E; Mohamedmohaideen Nilofar N; Deechongkit Songpon; Chiang Kyle P; Dendle Maria T A; Sacchettini James C; Kelly Jeffery W
Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action.
Angewandte Chemie (International ed. in English) 2003;42(24):2758-61.
2003: Zhang Fengli; Lücke Christian; Baier Leslie J; Sacchettini James C; Hamilton James A
Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism.
Biochemistry 2003;42(24):7339-47.
2003: Kremer Laurent; Dover Lynn G; Morbidoni Hector R; Vilchèze Catherine; Maughan William N; Baulard Alain; Tu Shiao-Chun; Honoré Nadine; Deretic Vojo; Sacchettini James C; Locht Camille; Jacobs William R; Besra Gurdyal S
Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.
The Journal of biological chemistry 2003;278(23):20547-54.
2003: Kuo Mack R; Morbidoni Hector R; Alland David; Sneddon Scott F; Gourlie Brian B; Staveski Mark M; Leonard Marina; Gregory Jill S; Janjigian Andrew D; Yee Christopher; Musser James M; Kreiswirth Barry; Iwamoto Hiroyuki; Perozzo Remo; Jacobs William R; Sacchettini James C; Fidock David A
Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data.
The Journal of biological chemistry 2003;278(23):20851-9.
2003: Gokulan Kuppan; Rupp Bernhard; Pavelka Martin S; Jacobs William R; Sacchettini James C
Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis.
The Journal of biological chemistry 2003;278(20):18588-96.
2003: Sharma Vivek; Arockiasamy Arulandu; Ronning Donald R; Savva Christos G; Holzenburg Andreas; Braunstein Miriam; Jacobs William R; Sacchettini James C
Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2243-8.
2003: Cho Yoonsang; Sharma Vivek; Sacchettini James C
Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis.
The Journal of biological chemistry 2003;278(10):8333-9.
2003: Smith Clare V; Huang Chih-chin; Miczak Andras; Russell David G; Sacchettini James C; Höner zu Bentrup Kerstin
Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis.
The Journal of biological chemistry 2003;278(3):1735-43.
2003: Ioerger Thomas R; Sacchettini James C
TEXTAL system: artificial intelligence techniques for automated protein model building.
Methods in enzymology 2003;374():244-70.
2002: Ioerger Thomas R; Sacchettini James C
Automatic modeling of protein backbones in electron-density maps via prediction of Calpha coordinates.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 12):2043-54.
2002: Adams Paul D; Grosse-Kunstleve Ralf W; Hung Li Wei; Ioerger Thomas R; McCoy Airlie J; Moriarty Nigel W; Read Randy J; Sacchettini James C; Sauter Nicholas K; Terwilliger Thomas C
PHENIX: building new software for automated crystallographic structure determination.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 11):1948-54.
2002: Larsen Michelle H; Vilchèze Catherine; Kremer Laurent; Besra Gurdyal S; Parsons Linda; Salfinger Max; Heifets Leonid; Hazbon Manzour H; Alland David; Sacchettini James C; Jacobs William R
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.
Molecular microbiology 2002;46(2):453-66.
2002: Riley-Lovingshimer Michelle R; Ronning Donald R; Sacchettini James C; Reinhart Gregory D
Reversible ligand-induced dissociation of a tryptophan-shift mutant of phosphofructokinase from Bacillus stearothermophilus.
Biochemistry 2002;41(43):12967-74.
2002: Goulding Celia W; Apostol Marcin; Anderson Daniel H; Gill Harindarpal S; Smith Clare V; Kuo Mack R; Yang Jin Kuk; Waldo Geoffrey S; Suh Se Won; Chauhan Radha; Kale Avinash; Bachhawat Nandita; Mande Shekhar C; Johnston Jodie M; Lott J Shaun; Baker Edward N; Arcus Vickery L; Leys David; McLean Kirsty J; Munro Andrew W; Berendzen Joel; Sharma Vivek; Park Min S; Eisenberg David; Sacchettini James; Alber Tom; Rupp Bernhard; Jacobs William; Terwilliger Thomas C
The TB structural genomics consortium: providing a structural foundation for drug discovery.
Current drug targets. Infectious disorders 2002;2(2):121-41.
2002: Eicken Christoph; Sharma Vivek; Klabunde Thomas; Lawrenz Matthew B; Hardham John M; Norris Steven J; Sacchettini James C
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi.
The Journal of biological chemistry 2002;277(24):21691-6.
2002: Sacchettini James C; Kelly Jeffery W
Therapeutic strategies for human amyloid diseases.
Nature reviews. Drug discovery 2002;1(4):267-75.
2002: Perozzo Remo; Kuo Mack; Sidhu Amar bir Singh; Valiyaveettil Jacob T; Bittman Robert; Jacobs William R; Fidock David A; Sacchettini James C
Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase.
The Journal of biological chemistry 2002;277(15):13106-14.
2002: Huang Chih-chin; Smith Clare V; Glickman Michael S; Jacobs William R; Sacchettini James C
Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis.
The Journal of biological chemistry 2002;277(13):11559-69.
2002: Yang Dong; Shipman Lance W; Roessner Charles A; Scott A Ian; Sacchettini James C
Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily.
The Journal of biological chemistry 2002;277(11):9462-7.
2001: Jiang X; Smith C S; Petrassi H M; Hammarström P; White J T; Sacchettini J C; Kelly J W
An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured.
Biochemistry 2001;40(38):11442-52.
2001: Shipman L W; Li D; Roessner C A; Scott A I; Sacchettini J C
Crystal structure of precorrin-8x methyl mutase.
Structure (London, England : 1993) 2001;9(7):587-96.
2001: Sacchettini J C; Baum L G; Brewer C F
Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction.
Biochemistry 2001;40(10):3009-15.
2001: Thomson C T; Kalergis A M; Sacchettini J C; Nathenson S G
A structural difference limited to one residue of the antigenic peptide can profoundly alter the biological outcome of the TCR-peptide/MHC class I interaction.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3994-7.
2001: Eicken C; Sharma V; Klabunde T; Owens R T; Pikas D S; Höök M; Sacchettini J C
Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi.
The Journal of biological chemistry 2001;276(13):10010-5.
2000: Sacchettini J C; Ronning D R
The mycobacterial antigens 85 complex--from structure to function: response.
Trends in microbiology 2000;8(10):441.
2000: Balendiran G K; Schnutgen F; Scapin G; Borchers T; Xhong N; Lim K; Godbout R; Spener F; Sacchettini J C
Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein.
The Journal of biological chemistry 2000;275(35):27045-54.
2000: McKinney J D; Höner zu Bentrup K; Muñoz-Elías E J; Miczak A; Chen B; Chan W T; Swenson D; Sacchettini J C; Jacobs W R; Russell D G
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.
Nature 2000;406(6797):735-8.
2000: Sharma V; Sharma S; Hoener zu Bentrup K; McKinney J D; Russell D G; Jacobs W R; Sacchettini J C
Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.
Nature structural biology 2000;7(8):663-8.
2000: Vilchèze C; Morbidoni H R; Weisbrod T R; Iwamoto H; Kuo M; Sacchettini J C; Jacobs W R
Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis.
Journal of bacteriology 2000;182(14):4059-67.
2000: Holton T; Ioerger T R; Christopher J A; Sacchettini J C
Determining protein structure from electron-density maps using pattern matching.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 6):722-34.
2000: Klabunde T; Petrassi H M; Oza V B; Raman P; Kelly J W; Sacchettini J C
Rational design of potent human transthyretin amyloid disease inhibitors.
Nature structural biology 2000;7(4):312-21.
2000: Ronning D R; Klabunde T; Besra G S; Vissa V D; Belisle J T; Sacchettini J C
Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.
Nature structural biology 2000;7(2):141-6.
1999: Eicken C; Krebs B; Sacchettini J C
Catechol oxidase - structure and activity.
Current opinion in structural biology 1999;9(6):677-83.
1999: Balendiran G K; Molina J A; Xu Y; Torres-Martinez J; Stevens R; Focia P J; Eakin A E; Sacchettini J C; Craig S P
Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding.
Protein science : a publication of the Protein Society 1999;8(5):1023-31.
1999: Rozwarski D A; Vilchèze C; Sugantino M; Bittman R; Sacchettini J C
Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate.
The Journal of biological chemistry 1999;274(22):15582-9.
1999: Ioerger T R; Holton T; Christopher J A; Sacchettini J C
TEXTAL: a pattern recognition system for interpreting electron density maps.
Proceedings / ... International Conference on Intelligent Systems for Molecular Biology ; ISMB. International Conference on Intelligent Systems for Molecular Biology 1999;():130-7.
1998: Sharma V; Grubmeyer C; Sacchettini J C
Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target.
Structure (London, England : 1993) 1998;6(12):1587-99.
1998: Klabunde T; Eicken C; Sacchettini J C; Krebs B
Crystal structure of a plant catechol oxidase containing a dicopper center.
Nature structural biology 1998;5(12):1084-90.
1998: Rozwarski D A; Swami B M; Brewer C F; Sacchettini J C
Crystal structure of the lectin from Dioclea grandiflora complexed with core trimannoside of asparagine-linked carbohydrates.
The Journal of biological chemistry 1998;273(49):32818-25.
1998: Banerjee A; Sugantino M; Sacchettini J C; Jacobs W R
The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.
Microbiology (Reading, England) 1998;144 ( Pt 10)():2697-704.
1998: Peterson S A; Klabunde T; Lashuel H A; Purkey H; Sacchettini J C; Kelly J W
Inhibiting transthyretin conformational changes that lead to amyloid fibril formation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):12956-60.
1998: Lim K; Owens S M; Arnold L; Sacchettini J C; Linthicum D S
Crystal structure of monoclonal 6B5 Fab complexed with phencyclidine.
The Journal of biological chemistry 1998;273(44):28576-82.
1998: Degano M; Almo S C; Sacchettini J C; Schramm V L
Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor.
Biochemistry 1998;37(18):6277-85.
1998: Klabunde T; Sharma S; Telenti A; Jacobs W R; Sacchettini J C
Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing.
Nature structural biology 1998;5(1):31-6.
1998: Rozwarski D A; Grant G A; Barton D H; Jacobs W R; Sacchettini J C
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
Science (New York, N.Y.) 1998;279(5347):98-102.
1998: Miesel L; Rozwarski D A; Sacchettini J C; Jacobs W R
Mechanisms for isoniazid action and resistance.
Novartis Foundation symposium 1998;217():209-20; discussion 220-1.
1997: Young A C; Valadon P; Casadevall A; Scharff M D; Sacchettini J C
The three-dimensional structures of a polysaccharide binding antibody to Cryptococcus neoformans and its complex with a peptide from a phage display library: implications for the identification of peptide mimotopes.
Journal of molecular biology 1997;274(4):622-34.
1997: Olsen L R; Dessen A; Gupta D; Sabesan S; Sacchettini J C; Brewer C F
X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin.
Biochemistry 1997;36(49):15073-80.
1997: Balendiran G K; Solheim J C; Young A C; Hansen T H; Nathenson S G; Sacchettini J C
The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6880-5.
1997: Zhang F; Lücke C; Baier L J; Sacchettini J C; Hamilton J A
Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit.
Journal of biomolecular NMR 1997;9(3):213-28.
1997: Xu Y; Eads J; Sacchettini J C; Grubmeyer C
Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: rapid phosphoribosyl transfer chemistry.
Biochemistry 1997;36(12):3700-12.
1997: Eads J C; Ozturk D; Wexler T B; Grubmeyer C; Sacchettini J C
A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase.
Structure (London, England : 1993) 1997;5(1):47-58.
1996: Tarshis L C; Proteau P J; Kellogg B A; Sacchettini J C; Poulter C D
Regulation of product chain length by isoprenyl diphosphate synthases.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15018-23.
1996: Irigoyen M; Kowal C; Young A C; Sacchettini J C; Diamond B
Molecular mapping of the 8.12 SLE-associated idiotype specificity at the single amino acid level.
Molecular immunology 1996;33(16):1255-65.
1996: Lücke C; Zhang F; Rüterjans H; Hamilton J A; Sacchettini J C
Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein.
Structure (London, England : 1993) 1996;4(7):785-800.
1996: Degano M; Gopaul D N; Scapin G; Schramm V L; Sacchettini J C
Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata.
Biochemistry 1996;35(19):5971-81.
1996: Gopaul D N; Meyer S L; Degano M; Sacchettini J C; Schramm V L
Inosine-uridine nucleoside hydrolase from Crithidia fasciculata. Genetic characterization, crystallization, and identification of histidine 241 as a catalytic site residue.
Biochemistry 1996;35(19):5963-70.
1996: Baier L J; Bogardus C; Sacchettini J C
A polymorphism in the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells.
The Journal of biological chemistry 1996;271(18):10892-6.
1996: Sacchettini J C; Blanchard J S
The structure and function of the isoniazid target in M. tuberculosis.
Research in microbiology 1996;147(1-2):36-43.
1995: Ozturk D H; Dorfman R H; Scapin G; Sacchettini J C; Grubmeyer C
Structure and function of Salmonella typhimurium orotate phosphoribosyltransferase: protein complementation reveals shared active sites.
Biochemistry 1995;34(34):10764-70.
1995: Ozturk D H; Dorfman R H; Scapin G; Sacchettini J C; Grubmeyer C
Locations and functional roles of conserved lysine residues in Salmonella typhimurium orotate phosphoribosyltransferase.
Biochemistry 1995;34(34):10755-63.
1995: Scapin G; Ozturk D H; Grubmeyer C; Sacchettini J C
The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate.
Biochemistry 1995;34(34):10744-54.
1995: Quémard A; Sacchettini J C; Dessen A; Vilcheze C; Bittman R; Jacobs W R; Blanchard J S
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.
Biochemistry 1995;34(26):8235-41.
1995: Dessen A; Gupta D; Sabesan S; Brewer C F; Sacchettini J C
X-ray crystal structure of the soybean agglutinin cross-linked with a biantennary analog of the blood group I carbohydrate antigen.
Biochemistry 1995;34(15):4933-42.
1995: Scapin G; Blanchard J S; Sacchettini J C
Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase.
Biochemistry 1995;34(11):3502-12.
1995: Reddy S G; Sacchettini J C; Blanchard J S
Expression, purification, and characterization of Escherichia coli dihydrodipicolinate reductase.
Biochemistry 1995;34(11):3492-501.
1995: Dessen A; Quémard A; Blanchard J S; Jacobs W R; Sacchettini J C
Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Science (New York, N.Y.) 1995;267(5204):1638-41.
1995: Baier L J; Sacchettini J C; Knowler W C; Eads J; Paolisso G; Tataranni P A; Mochizuki H; Bennett P H; Bogardus C; Prochazka M
An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.
The Journal of clinical investigation 1995;95(3):1281-7.
1995: Young A C; Nathenson S G; Sacchettini J C
Structural studies of class I major histocompatibility complex proteins: insights into antigen presentation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(1):26-36.
1995: Young A C; Zhang W; Sacchettini J C; Nathenson S G
MHC class I-peptide interactions and TCR recognition.
Cancer surveys 1995;22():17-36.
1994: Dewan J C; Grant G A; Sacchettini J C
Crystal structure of kappa-bungarotoxin at 2.3-A resolution.
Biochemistry 1994;33(44):13147-54.
1994: Tarshis L C; Yan M; Poulter C D; Sacchettini J C
Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution.
Biochemistry 1994;33(36):10871-7.
1994: Eads J C; Scapin G; Xu Y; Grubmeyer C; Sacchettini J C
The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP.
Cell 1994;78(2):325-34.
1994: Mikami B; Degano M; Hehre E J; Sacchettini J C
Crystal structures of soybean beta-amylase reacted with beta-maltose and maltal: active site components and their apparent roles in catalysis.
Biochemistry 1994;33(25):7779-87.
1994: Young A C; Scapin G; Kromminga A; Patel S B; Veerkamp J H; Sacchettini J C
Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids.
Structure (London, England : 1993) 1994;2(6):523-34.
1994: Maatman R G; Degano M; Van Moerkerk H T; Van Marrewijk W J; Van der Horst D J; Sacchettini J C; Veerkamp J H
Primary structure and binding characteristics of locust and human muscle fatty-acid-binding proteins.
European journal of biochemistry / FEBS 1994;221(2):801-10.
1994: Scapin G; Grubmeyer C; Sacchettini J C
Crystal structure of orotate phosphoribosyltransferase.
Biochemistry 1994;33(6):1287-94.
1994: Young A C; Zhang W; Sacchettini J C; Nathenson S G
The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection.
Cell 1994;76(1):39-50.
1993: Eads J; Sacchettini J C; Kromminga A; Gordon J I
Escherichia coli-derived rat intestinal fatty acid binding protein with bound myristate at 1.5 A resolution and I-FABPArg106-->Gln with bound oleate at 1.74 A resolution.
The Journal of biological chemistry 1993;268(35):26375-85.
1993: Dewan J C; Mikami B; Hirose M; Sacchettini J C
Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release.
Biochemistry 1993;32(45):11963-8.
1993: Sacchettini J C; Gordon J I
Rat intestinal fatty acid binding protein. A model system for analyzing the forces that can bind fatty acids to proteins.
The Journal of biological chemistry 1993;268(25):18399-402.
1993: Mikami B; Hehre E J; Sato M; Katsube Y; Hirose M; Morita Y; Sacchettini J C
The 2.0-A resolution structure of soybean beta-amylase complexed with alpha-cyclodextrin.
Biochemistry 1993;32(27):6836-45.
1993: Scapin G; Young A C; Kromminga A; Veerkamp J H; Gordon J I; Sacchettini J C
High resolution X-ray studies of mammalian intestinal and muscle fatty acid-binding proteins provide an opportunity for defining the chemical nature of fatty acid: protein interactions.
Molecular and cellular biochemistry 1993;123(1-2):3-13.
1993: Scapin G; Sacchettini J C; Dessen A; Bhatia M; Grubmeyer C
Primary structure and crystallization of orotate phosphoribosyltransferase from Salmonella typhimurium.
Journal of molecular biology 1993;230(4):1304-8.
1992: Sacchettini J C; Scapin G; Gopaul D; Gordon J I
Refinement of the structure of Escherichia coli-derived rat intestinal fatty acid binding protein with bound oleate to 1.75-A resolution. Correlation with the structures of the apoprotein and the protein with bound palmitate.
The Journal of biological chemistry 1992;267(33):23534-45.
1992: Zanotti G; Scapin G; Spadon P; Veerkamp J H; Sacchettini J C
Three-dimensional structure of recombinant human muscle fatty acid-binding protein.
The Journal of biological chemistry 1992;267(26):18541-50.
1992: Zhang W; Young A C; Imarai M; Nathenson S G; Sacchettini J C
Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8403-7.
1992: Scapin G; Gordon J I; Sacchettini J C
Refinement of the structure of recombinant rat intestinal fatty acid-binding apoprotein at 1.2-A resolution.
The Journal of biological chemistry 1992;267(6):4253-69.
1990: Sacchettini J C; Hauft S M; Van Camp S L; Cistola D P; Gordon J I
Developmental and structural studies of an intracellular lipid binding protein expressed in the ileal epithelium.
The Journal of biological chemistry 1990;265(31):19199-207.
1990: Sacchettini J C; Banaszak L J; Gordon J I
Expression of rat intestinal fatty acid binding protein in E. coli and its subsequent structural analysis: a model system for studying the molecular details of fatty acid-protein interaction.
Molecular and cellular biochemistry 1990;98(1-2):81-93.
1990: Cistola D P; Sacchettini J C; Gordon J I
13C NMR studies of fatty acid-protein interactions: comparison of homologous fatty acid-binding proteins produced in the intestinal epithelium.
Molecular and cellular biochemistry 1990;98(1-2):101-10.
1989: Sacchettini J C; Gordon J I; Banaszak L J
Refined apoprotein structure of rat intestinal fatty acid binding protein produced in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7736-40.
1989: Sacchettini J C; Gordon J I; Banaszak L J
Crystal structure of rat intestinal fatty-acid-binding protein. Refinement and analysis of the Escherichia coli-derived protein with bound palmitate.
Journal of molecular biology 1989;208(2):327-39.
1989: Cistola D P; Sacchettini J C; Banaszak L J; Walsh M T; Gordon J I
Fatty acid interactions with rat intestinal and liver fatty acid-binding proteins expressed in Escherichia coli. A comparative 13C NMR study.
The Journal of biological chemistry 1989;264(5):2700-10.

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