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James Sacchettini

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Michael A DeJesus; Eric J Rubin; James C Sacchettini; Christopher M Sassetti; Yanjia J Zhang; Thomas R Ioerger
Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries.
John W Anderson; Sean Ekins; Fidock David; Arba Ager; William R Jacobs; David P Jacobus; Mack Kuo; James C Sacchettini; Dimitri Sarantakis; Guy A Schiehser; Jacek Terpinski; Han-Chun Tsai; T R Santha Kumar; Joel S Freundlich
Novel diaryl ureas with efficacy in a mouse model of malaria.
Krishnamoorthy Gopinath; Thomas R Ioerger; John D McKinney; Valerie Mizrahi; James C Sacchettini; Ceslovas Venclovas; Digby F Warner
A vitamin B₁₂ transporter in Mycobacterium tuberculosis.

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2013: Michael A DeJesus; Eric J Rubin; James C Sacchettini; Christopher M Sassetti; Yanjia J Zhang; Thomas R Ioerger
Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries.
Bioinformatics (Oxford, England) 2013;29(6):695-703.
2013: John W Anderson; Sean Ekins; Fidock David; Arba Ager; William R Jacobs; David P Jacobus; Mack Kuo; James C Sacchettini; Dimitri Sarantakis; Guy A Schiehser; Jacek Terpinski; Han-Chun Tsai; T R Santha Kumar; Joel S Freundlich
Novel diaryl ureas with efficacy in a mouse model of malaria.
Bioorganic & medicinal chemistry letters 2013;23(4):1022-5.
2013: Krishnamoorthy Gopinath; Thomas R Ioerger; John D McKinney; Valerie Mizrahi; James C Sacchettini; Ceslovas Venclovas; Digby F Warner
A vitamin B₁₂ transporter in Mycobacterium tuberculosis.
Open biology 2013;3(2):120175.
2013: Michael A DeJesus; James C Sacchettini; Thomas R Ioerger
Reannotation of translational start sites in the genome of Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2013;93(1):18-25.
2012: Inna V Krieger; Jose-Luis Lavandera; Joshua L Owen; Justin P Roberts; Maria T Fraile; Joel S Freundlich; Vijay B Gawandi; Vidyadhar B Gawandi; Sofia I Huss; Thomas R Ioerger; Qingan Sun; James C Sacchettini
Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chemistry & biology 2012;19(12):1556-67.
2012: Jade N James; Christian Palavecino; Yoann Personne; James C Sacchettini; Natasha L Tilston-Lunel; Amanda C Brown; Paul Carroll; Zeeshaan-ul Hasan; Melanie Ikeh; Thomas R Ioerger; Tanya Parish
Deletion of SenX3-RegX3, a key two-component regulatory system of Mycobacterium smegmatis, results in growth defects under phosphate-limiting conditions.
Microbiology (Reading, England) 2012;158(Pt 11):2724-31.
2012: Hexin Xie; James C Sacchettini; Chris N Thornton; MiHee Chang; Jeffrey D Cirillo; Hany A Hassounah; Ying Kong; Joseph Mire; Jianghong Rao
Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe.
Nature chemistry 2012;4(10):802-9.
2012: Yanjia J Zhang; James C Sacchettini; Christopher M Sassetti; Curtis Huttenhower; Thomas R Ioerger; Jarukit E Long; Eric J Rubin
Global assessment of genomic regions required for growth in Mycobacterium tuberculosis.
PLoS pathogens 2012;8(9):e1002946.
2012: Samir H Moussa; James C Sacchettini; Tram Anh T Tran; Vladimir Kuznetsov; Ry Young
Protein determinants of phage T4 lysis inhibition.
Protein science : a publication of the Protein Society 2012;21(4):571-82.
2012: Rockann Mosser; Manchi C M Reddy; John B Bruning; James C Sacchettini; Gregory D Reinhart
Structure of the apo form of Bacillus stearothermophilus phosphofructokinase.
Biochemistry 2012;51(3):769-75.
2012: Bing-Shao Chia; Viktor Einarsson; Aubrey Herrera; Thomas R Ioerger; Jaime Bravo; Elizabeth Y Kim; Fedora Lanzas; Purvaja Narayanaswamy; Juan M Pascale; Dalin Rifat; James C Sacchettini; Christine Sailer; Edith Torres-Chavolla; Petros C Karakousis
Use of multiplex allele-specific polymerase chain reaction (MAS-PCR) to detect multidrug-resistant tuberculosis in Panama.
PloS one 2012;7(7):e40456.
2011: Bhaskara Reddy Madina; Laurie K Read; James C Sacchettini; Sing-Hoi Sze; Ajay A Vashisht; James Wohlschlegel; Kurtis M Downey; Xinhua Ji; Gokulan Kuppan; Yu-He Liang; Jorge Cruz-Reyes
Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei.
RNA (New York, N.Y.) 2011;17(10):1821-30.
2011: Kuppan Gokulan; Anup Aggarwal; Gurdyal S Besra; Lance Shipman; James C Sacchettini
Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations.
Acta crystallographica. Section D, Biological crystallography 2011;67(Pt 7):657-69.
2011: Marcio V B Dias; William C Snee; Karen M Bromfield; Richard J Payne; Satheesh K Palaninathan; Alessio Ciulli; Nigel I Howard; Chris Abell; James C Sacchettini; Tom L Blundell
Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.
The Biochemical journal 2011;436(3):729-39.
2011: Christopher B Ford; Philana Ling Lin; Michael R Chase; Rupal R Shah; Oleg Iartchouk; James E Galagan; Nilofar Mohaideen; Thomas R Ioerger; James C Sacchettini; Marc Lipsitch; JoAnne L Flynn; Sarah Fortune
Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection.
Nature genetics 2011;43(5):482-6.
2011: Arulandu Arockiasamy; Anup Aggarwal; Christos G Savva; Andreas Holzenburg; James C Sacchettini
Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site.
Protein science : a publication of the Protein Society 2011;20(5):827-33.
2011: Nicholas Chim; Jeff E Habel; Jodie M Johnston; Inna Krieger; linda miallau; Ramasamy Sankaranarayanan; Robert P Morse; John Bruning; Stephanie Swanson; Haelee Kim; Chang-Yub Kim; Hongye Li; Esther M Bulloch; Richard J Payne; Alexandra Manos-Turvey; Li-Wei Hung; Edward N Baker; J Shaun Lott; Michael N G James; Thomas C Terwilliger; David S Eisenberg; James C Sacchettini; Celia W Goulding
The TB Structural Genomics Consortium: a decade of progress.
Tuberculosis (Edinburgh, Scotland) 2011;91(2):155-72.
2011: John B Bruning; Ana C Murillo; Ofelia Chacon; Raúl G Barletta; James C Sacchettini
Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine.
Antimicrobial agents and chemotherapy 2011;55(1):291-301.
2010: Virginie Molle; Gulcin Gulten; Catherine Vilchèze; Romain Veyron-Churlet; Isabelle Zanella-Cléon; James C Sacchettini; William R. Jacobs Jr.; Laurent Kremer
Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis.
Molecular microbiology 2010;78(6):1591-605.
2010: Joel S Freundlich; Mallikarjun Lalgondar; Jun-Rong Wei; Stephanie Swanson; Erik J Sorensen; Eric J Rubin; James C Sacchettini
The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2010;90(5):298-300.
2010: Michael G Drage; Han-Chun Tsai; Nicole D Pecora; Tan-Yun Cheng; Ahmad R Arida; Supriya Shukla; Roxana E Rojas; Chetan Seshadri; D Branch Moody; W Henry Boom; James C Sacchettini; Clifford V Harding
Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.
Nature structural & molecular biology 2010;17(9):1088-95.
2010: Feng Wang; Paras Jain; Gulcin Gulten; Zhen Liu; Yicheng Feng; Krishna Ganesula; Alifiya S Motiwala; Thomas R Ioerger; David Alland; Catherine Vilchèze; William R. Jacobs Jr.; James C Sacchettini
Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid.
Antimicrobial agents and chemotherapy 2010;54(9):3776-82.
2010: Sanghamitra Dey; James M Lane; Richard E Lee; Eric J Rubin; James C Sacchettini
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
Biochemistry 2010;49(31):6746-60.
2010: Nishant D Shetty; Manchi C M Reddy; Satheesh K Palaninathan; Joshua L Owen; James C Sacchettini
Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein.
Protein science : a publication of the Protein Society 2010;19(8):1513-24.
2010: Ying Kong; Hequan Yao; Hongjun Ren; Selvakumar Subbian; Suat L G Cirillo; James C Sacchettini; Jianghong Rao; Jeffrey D Cirillo
Imaging tuberculosis with endogenous beta-lactamase reporter enzyme fluorescence in live mice.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(27):12239-44.
2010: Thomas R Ioerger; Yicheng Feng; Krishna Ganesula; Xiaohua Chen; Karen M Dobos; Sarah Fortune; William R. Jacobs Jr.; Valerie Mizrahi; Tanya Parish; Eric Rubin; Chris Sassetti; James C Sacchettini
Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories.
Journal of bacteriology 2010;192(14):3645-53.
2010: Rainer Kalscheuer; Karl Syson; Usha Veeraraghavan; Brian Charles Weinrick; Karolin E Biermann; Zhen Liu; James C Sacchettini; Gurdyal Besra; Stephen Bornemann; William R. Jacobs Jr.
Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway.
Nature chemical biology 2010;6(5):376-84.
2010: Bavesh D Kana; Garth L Abrahams; Nackmoon Sung; Digby F Warner; Bhavna G Gordhan; Edith E Machowski; Liana Tsenova; James C Sacchettini; neil stoker; Gilla Kaplan; Valerie Mizrahi
Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis.
Journal of bacteriology 2010;192(8):2220-7.
2010: Thomas R Ioerger; Yicheng Feng; Xiaohua Chen; Karen M Dobos; Thomas C Victor; Elizabeth M Streicher; Robin M Warren; Nicolaas C Gey van Pittius; Paul D Van Helden; James C Sacchettini
The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa.
BMC genomics 2010;11():670.
2009: Manchi C M Reddy; Satheesh K Palaninathan; John B Bruning; Cory Thurman; Danielle Smith; James C Sacchettini
Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein.
The Journal of biological chemistry 2009;284(52):36581-91.
2009: Qingan Sun; Gabriel F Kuty; Arulandu Arockiasamy; Min Xu; Ry Young; James C Sacchettini
Regulation of a muralytic enzyme by dynamic membrane topology.
Nature structural & molecular biology 2009;16(11):1192-4.
2009: Stephanie Swanson; Kuppan Gokulan; James C Sacchettini
KasA, another brick in the mycobacterial cell wall.
Structure (London, England : 1993) 2009;17(7):914-5.
2009: Thomas R Ioerger; James C Sacchettini
Structural genomics approach to drug discovery for Mycobacterium tuberculosis.
Current opinion in microbiology 2009;12(3):318-25.
2009: Daniel Barkan; Zhen Liu; James C Sacchettini; Michael S Glickman
Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.
Chemistry & biology 2009;16(5):499-509.
2009: Joel S Freundlich; Feng Wang; Catherine Vilchèze; Gulcin Gulten; Robert Langley; Guy A Schiehser; David P Jacobus; William R. Jacobs Jr.; James C Sacchettini
Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis.
ChemMedChem 2009;4(2):241-8.
2009: Tracey L Musa; Thomas R Ioerger; James C Sacchettini
The tuberculosis structural genomics consortium: a structural genomics approach to drug discovery.
Advances in protein chemistry and structural biology 2009;77():41-76.
2009: Thomas R Ioerger; Sunwoo Koo; Eun-Gyu No; Xiaohua Chen; Michelle H. Larsen; William R. Jacobs Jr.; Manormoney Pillay; A Willem Sturm; James C Sacchettini
Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.
PloS one 2009;4(11):e7778.
2009: Satheesh K Palaninathan; Nilofar N Mohamedmohaideen; Elisabetta Orlandini; Gabriella Ortore; Susanna Nencetti; Annalina Lapucci; Armando Rossello; Joel S Freundlich; James C Sacchettini
Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis.
PloS one 2009;4(7):e6290.
2008: Min Yu; T R Santha Kumar; Louis J Nkrumah; Alida Coppi; Silke Retzlaff; Celeste D Li; Brendan J Kelly; Pedro A Moura; Viswanathan Lakshmanan; Joel S Freundlich; Juan-Carlos Valderramos; Catherine Vilcheze; Mark Siedner; Jennifer H-C Tsai; Brie Falkard; Amar Bir Singh Sidhu; Lisa A Purcell; Paul Gratraud; Laurent Kremer; Andrew P Waters; Guy Schiehser; David P Jacobus; Chris J Janse; Arba Ager; William R. Jacobs Jr.; James C Sacchettini; Volker Heussler; Photini Sinnis; Fidock David
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Cell host & microbe 2008;4(6):567-78.
2008: Manchi C M Reddy; Gokulan Kuppan; Nishant D Shetty; Joshua L Owen; Thomas R Ioerger; James C Sacchettini
Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein science : a publication of the Protein Society 2008;17(12):2134-44.
2008: Satheesh K Palaninathan; Nilofar N Mohamedmohaideen; William C Snee; Jeffery W Kelly; James C Sacchettini
Structural insight into pH-induced conformational changes within the native human transthyretin tetramer.
Journal of molecular biology 2008;382(5):1157-67.
2008: Yoonsang Cho; Thomas R Ioerger; James C Sacchettini
Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening.
Journal of medicinal chemistry 2008;51(19):5984-92.
2008: Catherine Vilchèze; Yossef Av-Gay; Rodgoun Attarian; Zhen Liu; Manzour Hernando Hazbón; Roberto Colangeli; Bing Chen; Weijun Liu; David Alland; James C Sacchettini; William R. Jacobs Jr.
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.
Molecular microbiology 2008;69(5):1316-29.
2008: Sanghamitra Dey; Rodney L Burton; Gregory A Grant; James C Sacchettini
Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase.
Biochemistry 2008;47(32):8271-82.
2008: Sreedhar Chinnaswamy; Ian Yarbrough; Satheesh K Palaninathan; C T Ranjith Kumar; Vinodhini Vijayaraghavan; Borries Demeler; Stanley M Lemon; James C Sacchettini; C Cheng Kao
A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase.
The Journal of biological chemistry 2008;283(29):20535-46.
2008: Nilofar N Mohamedmohaideen; Satheesh K Palaninathan; Paul M Morin; Brad J Williams; Miriam Braunstein; Shane E Tichy; Joseph Locker; David H Russell; William R. Jacobs Jr.; James C Sacchettini
Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis.
Biochemistry 2008;47(23):6092-102.
2008: Farah Javid-Majd; Dong Yang; Thomas R Ioerger; James C Sacchettini
The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 6):627-35.
2008: Kanchan Bhardwaj; Satheesh Palaninathan; Joanna Maria Ortiz Alcantara; Lillian Li Yi; Linda Guarino; James C Sacchettini; C Cheng Kao
Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15.
The Journal of biological chemistry 2008;283(6):3655-64.
2008: Peter H Zwart; Pavel V Afonine; Ralf W Grosse-Kunstleve; Li-Wei Hung; Thomas R Ioerger; Airlie J McCoy; Erik McKee; Nigel W Moriarty; Randy J Read; James C Sacchettini; Nicholas K Sauter; Laurent C Storoni; Thomas C Terwilliger; Paul D Adams
Automated structure solution with the PHENIX suite.
Methods in molecular biology (Clifton, N.J.) 2008;426():419-35.
2008: James C Sacchettini; Eric J Rubin; Joel S Freundlich
Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis.
Nature reviews. Microbiology 2008;6(1):41-52.
2008: Manchi C M Reddy; Kuppan Gokulan; William R. Jacobs Jr.; Thomas R Ioerger; James C Sacchettini
Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response.
Protein science : a publication of the Protein Society 2008;17(1):159-70.
2007: Hyojeung Kang; Kanchan Bhardwaj; Yi Li; Satheesh Palaninathan; James C Sacchettini; Linda A Guarino; Julian L Leibowitz; C Cheng Kao
Biochemical and genetic analyses of murine hepatitis virus Nsp15 endoribonuclease.
Journal of virology 2007;81(24):13587-97.
2007: Manchi C M Reddy; Satheesh K Palaninathan; Nishant D Shetty; Joshua L Owen; Misty D Watson; James C Sacchettini
High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme.
The Journal of biological chemistry 2007;282(37):27334-42.
2007: Joel S Freundlich; Feng Wang; Han-Chun Tsai; Mack Kuo; Hong-Ming Shieh; John W Anderson; Louis J Nkrumah; Juan-Carlos Valderramos; Min Yu; T R Santha Kumar; Stephanie G Valderramos; William R. Jacobs Jr.; Guy A Schiehser; David P Jacobus; Fidock David; James C Sacchettini
X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
The Journal of biological chemistry 2007;282(35):25436-44.
2007: George Nicola; Colin A Smith; Edinson Lucumi; Mack R Kuo; Luchezar Karagyozov; Fidock David; James C Sacchettini; Ruben Abagyan
Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening.
Biochemical and biophysical research communications 2007;358(3):686-91.
2007: Chi-Lin Tsai; Kuppan Gokulan; Pablo Sobrado; James C Sacchettini; Paul F Fitzpatrick
Mechanistic and structural studies of H373Q flavocytochrome b2: effects of mutating the active site base.
Biochemistry 2007;46(26):7844-51.
2007: Xiaomin Cai; A Lorraine Fuller; Larry R McDougald; Xiangshi Tan; Jianping Cai; Feng Wang; James C Sacchettini; Guan Zhu
Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa).
FEMS microbiology letters 2007;272(2):238-44.
2007: Sanghamitra Dey; Zhiqin Hu; Xiao Lan Xu; James C Sacchettini; Gregory A Grant
The effect of hinge mutations on effector binding and domain rotation in Escherichia coli D-3-phosphoglycerate dehydrogenase.
The Journal of biological chemistry 2007;282(25):18418-26.
2007: A C Murillo; H Y Li; Thomas Alber; Edward N Baker; James M Berger; Leonid T Cherney; M M Cherney; Yoon Song Cho; David Eisenberg; Craig Garen; Celia W Goulding; Li-Wei Hung; Thomas R Ioerger; William R. Jacobs Jr.; Michael N G James; C Kim; I Krieger; J S Lott; R Sankaranarayanan; Brent W Segelke; Thomas C Terwilliger; F Wang; S Wang; James C Sacchettini
High throughput crystallography of TB drug targets.
Infectious disorders drug targets 2007;7(2):127-39.
2007: Arati Ramesh; Christos G Savva; Andreas Holzenburg; James C Sacchettini
Crystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA binding activity.
The Journal of biological chemistry 2007;282(20):14960-7.
2007: Feng Wang; Robert Langley; Gulcin Gulten; Lei Wang; James C Sacchettini
Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence.
Chemistry & biology 2007;14(5):543-51.
2007: sudharsan sridharan; Lei Wang; Alistair K Brown; Lynn Dover; Laurent Kremer; Gurdyal S Besra; James C Sacchettini
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).
Journal of molecular biology 2007;366(2):469-80.
2007: Kreshna Gopal; Erik McKee; Tod D Romo; Reetal Pai; Jacob Smith; James C Sacchettini; Thomas R Ioerger
Crystallographic protein model-building on the web.
Bioinformatics (Oxford, England) 2007;23(3):375-7.
2007: Amar Bir Singh Sidhu; Qingan Sun; Louis J Nkrumah; Michael W Dunne; James C Sacchettini; Fidock David
In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin.
The Journal of biological chemistry 2007;282(4):2494-504.
2007: Feng Wang; Robert Langley; Gulcin Gulten; Lynn Dover; Gurdyal S Besra; William R. Jacobs Jr.; James C Sacchettini
Mechanism of thioamide drug action against tuberculosis and leprosy.
The Journal of experimental medicine 2007;204(1):73-8.
2007: Anuradha Alahari; Xavier Trivelli; Yann Guérardel; Lynn Dover; Gurdyal S Besra; James C Sacchettini; Robert C Reynolds; Geoffrey D Coxon; Laurent Kremer
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.
PloS one 2007;2(12):e1343.
2007: Tong Liu; Arati Ramesh; Zhen Ma; Sarah K Ward; Limei Zhang; Graham Neil George; Adel M Talaat; James C Sacchettini; David P Giedroc
CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.
Nature chemical biology 2007;3(1):60-8.
2006: Tod D Romo; James C Sacchettini; Thomas R Ioerger
Improving amino-acid identification, fit and C(alpha) prediction using the Simplex method in automated model building.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 11):1401-6.
2006: Reetal Pai; James C Sacchettini; Thomas R Ioerger
Identifying non-crystallographic symmetry in protein electron-density maps: a feature-based approach.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 9):1012-21.
2006: Catherine Vilchèze; Feng Wang; Masayoshi Arai; Manzour Hernando Hazbón; Roberto Colangeli; Laurent Kremer; Torin R Weisbrod; David Alland; James C Sacchettini; William R. Jacobs Jr.
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.
Nature medicine 2006;12(9):1027-9.
2006: Ty A Gould; Helmus van de Langemheen; Ernesto J Muñoz-Elías; John D McKinney; James C Sacchettini
Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis.
Molecular microbiology 2006;61(4):940-7.
2006: Feng Wang; Craig Cassidy; James C Sacchettini
Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics.
Antimicrobial agents and chemotherapy 2006;50(8):2762-71.
2006: Robert Gaffin; Kuppan Gokulan; James C Sacchettini; Timothy E Hewett; Raisa Klevitsky; Jeffrey Robbins; Vandana Sarin; David C Zawieja; Gerald A Meininger; Mariappan Muthuchamy
Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics.
American journal of physiology. Heart and circulatory physiology 2006;291(2):H552-63.
2006: Róisín M Owens; Fong-Fu Hsu; Brian C VanderVen; Georgiana E Purdy; Elizabeth Hesteande; Peter Giannakas; James C Sacchettini; John D McKinney; Preston J Hill; John Belisle; Barbara A Butcher; Kevin Pethe; David G Russell
M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs).
Molecular microbiology 2006;60(5):1152-63.
2006: Joel S Freundlich; Min Yu; Edinson Lucumi; Mack Kuo; Han-Chun Tsai; Juan-Carlos Valderramos; Luchezar Karagyozov; William R. Jacobs Jr.; Guy A Schiehser; Fidock David; David P Jacobus; James C Sacchettini
Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.
Bioorganic & medicinal chemistry letters 2006;16(8):2163-9.
2006: Xiangbo Zhao; Hong Yu; Shengwei Yu; Feng Wang; James C Sacchettini; Richard Magliozzo
Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant.
Biochemistry 2006;45(13):4131-40.
2006: HECTOR MORBIDONI; Catherine Vilchèze; Laurent Kremer; Robert Bittman; James C Sacchettini; William R. Jacobs Jr.
Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids.
Chemistry & biology 2006;13(3):297-307.
2005: Saul R Trevino; Kuppan Gokulan; Stephanie Newsom; Richard L Thurlkill; Kevin L Shaw; Vladmir Mitkevich; Alexander A Makarov; James C Sacchettini; J Martin Scholtz; C Nick Pace
Asp79 makes a large, unfavorable contribution to the stability of RNase Sa.
Journal of molecular biology 2005;354(4):967-78.
2005: Joel S Freundlich; John W Anderson; Dimitri Sarantakis; Hong-Ming Shieh; Min Yu; Juan-Carlos Valderramos; Edinson Lucumi; Mack Kuo; William R. Jacobs Jr.; Fidock David; Guy A Schiehser; David P Jacobus; James C Sacchettini
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.
Bioorganic & medicinal chemistry letters 2005;15(23):5247-52.
2005: N Monique Paricharttanakul; Sheng Ye; Ann L Menefee; Farah Javid-Majd; James C Sacchettini; Gregory D Reinhart
Kinetic and structural characterization of phosphofructokinase from Lactobacillus bulgaricus.
Biochemistry 2005;44(46):15280-6.
2005: Apoorva Bhatt; Laurent Kremer; Annie Z Dai; James C Sacchettini; William R. Jacobs Jr.
Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.
Journal of bacteriology 2005;187(22):7596-606.
2005: E W McKee; L D Kanbi; Kevin L Childs; Ralf W Grosse-Kunstleve; Paul D Adams; James C Sacchettini; Thomas R Ioerger
FINDMOL: automated identification of macromolecules in electron-density maps.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 11):1514-20.
2005: Alistair K Brown; sudharsan sridharan; Laurent Kremer; Sandra Lindenberg; Lynn Dover; James C Sacchettini; Gurdyal S Besra
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
The Journal of biological chemistry 2005;280(37):32539-47.
2005: Kuppan Gokulan; Sangeeta Khare; Donald Ronning; Scott D Linthicum; James C Sacchettini; Bernhard Rupp
Cocrystal structures of NC6.8 Fab identify key interactions for high potency sweetener recognition: implications for the design of synthetic sweeteners.
Biochemistry 2005;44(29):9889-98.
2005: Tiyu Gao; Xiaofan Zhang; Youlin Xia; Yoonsang Cho; James C Sacchettini; Susan S Golden; Andy C LiWang
1H, 13C and 15N chemical shift assignments of the C-terminal, 133-residue pseudo-receiver domain of circadian input kinase (CikA) in Synechococcus elongatus.
Journal of biomolecular NMR 2005;32(3):259.
2005: Kreshna Gopal; Tod D Romo; James C Sacchettini; Thomas R Ioerger
Determining relevant features to recognize electron density patterns in x-ray protein crystallography.
Journal of bioinformatics and computational biology 2005;3(3):645-76.
2005: Sanghamitra Dey; Zhiqin Hu; Xiao Lan Xu; James C Sacchettini; Gregory A Grant
D-3-Phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes.
The Journal of biological chemistry 2005;280(15):14884-91.
2005: Sanghamitra Dey; Gregory A Grant; James C Sacchettini
Crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits.
The Journal of biological chemistry 2005;280(15):14892-9.
2005: Jeongeun Eun Lee; KYOUNGHYUN Kim; James C Sacchettini; Clare V Smith; Stephen Safe
DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.
The Journal of biological chemistry 2005;280(10):8819-30.
2005: Steven M Johnson; H Michael Petrassi; Satheesh K Palaninathan; Nilofar N Mohamedmohaideen; Hans E Purkey; Christopher Nichols; Kyle P. Chiang; Traci Walkup; James C Sacchettini; K Barry Sharpless; Jeffery W Kelly
Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
Journal of medicinal chemistry 2005;48(5):1576-87.
2005: Roberto Colangeli; danica helb; sudharsan sridharan; Jingchuan Sun; Mandira Varma-Basil; Manzour Hernando Hazbón; Ryhor Harbacheuski; Nicholas J Megjugorac; William R. Jacobs Jr.; Andreas Holzenburg; James C Sacchettini; David Alland
The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol.
Molecular microbiology 2005;55(6):1829-40.
2005: sudharsan sridharan; Abbas Razvi; J Martin Scholtz; James C Sacchettini
The HPr proteins from the thermophile Bacillus stearothermophilus can form domain-swapped dimers.
Journal of molecular biology 2005;346(3):919-31.
2005: Catherine Vilchèze; Torin R Weisbrod; Bing Chen; Laurent Kremer; Manzour Hernando Hazbón; Feng Wang; David Alland; James C Sacchettini; William R. Jacobs Jr.
Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.
Antimicrobial agents and chemotherapy 2005;49(2):708-20.
2005: Min Xu; Arockiasamy Arulandu; Douglas K Struck; Stephanie Swanson; James C Sacchettini; Ry Young
Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme.
Science (New York, N.Y.) 2005;307(5706):113-7.
2004: Hans E Purkey; Satheesh K Palaninathan; Kathleen C Kent; Craig Smith; Stephen H Safe; James C Sacchettini; Jeffery W Kelly
Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity.
Chemistry & biology 2004;11(12):1719-28.
2004: Donald Ronning; Varalakshmi D Vissa; Gurdyal S Besra; John Belisle; James C Sacchettini
Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity.
The Journal of biological chemistry 2004;279(35):36771-7.
2004: Sheng Ye; Ioannis Vakonakis; Thomas R Ioerger; Andy C LiWang; James C Sacchettini
Crystal structure of circadian clock protein KaiA from Synechococcus elongatus.
The Journal of biological chemistry 2004;279(19):20511-8.
2004: Robert Gaffin; Kuppan Gokulan; James C Sacchettini; Timothy E Hewett; Raisa Klevitsky; Jeffrey Robbins; Mariappan Muthuchamy
Charged residue changes in the carboxy-terminus of alpha-tropomyosin alter mouse cardiac muscle contractility.
The Journal of physiology 2004;556(Pt 2):531-43.
2004: Sara L Adamski-Werner; Satheesh K Palaninathan; James C Sacchettini; Jeffery W Kelly
Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
Journal of medicinal chemistry 2004;47(2):355-74.
2004: Kreshna Gopal; Tod D Romo; James C Sacchettini; Thomas R Ioerger
Weighting features to recognize 3D patterns of electron density in X-ray protein crystallography.
Proceedings / IEEE Computational Systems Bioinformatics Conference, CSB. IEEE Computational Systems Bioinformatics Conference 2004;():255-65.
2004: Clare V Smith; Vivek Sharma; James C Sacchettini
TB drug discovery: addressing issues of persistence and resistance.
Tuberculosis (Edinburgh, Scotland) 2004;84(1-2):45-55.
2004: Paul D Adams; Kreshna Gopal; Ralf W Grosse-Kunstleve; Li-Wei Hung; Thomas R Ioerger; Airlie J McCoy; Nigel W Moriarty; Reetal K Pai; Randy J Read; Tod D Romo; James C Sacchettini; Nicholas K Sauter; Laurent C Storoni; Thomas C Terwilliger
Recent developments in the PHENIX software for automated crystallographic structure determination.
Journal of synchrotron radiation 2004;11(Pt 1):53-5.
2003: Clare V Smith; James C Sacchettini
Mycobacterium tuberculosis: a model system for structural genomics.
Current opinion in structural biology 2003;13(6):658-64.
2003: Vinod Reddy; Stanley M Swanson; Brent W Segelke; Katherine A Kantardjieff; James C Sacchettini; Bernhard Rupp
Effective electron-density map improvement and structure validation on a Linux multi-CPU web cluster: The TB Structural Genomics Consortium Bias Removal Web Service.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2200-10.
2003: Nora S Green; Satheesh K Palaninathan; James C Sacchettini; Jeffery W Kelly
Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization.
Journal of the American Chemical Society 2003;125(44):13404-14.
2003: Christoph Eicken; Mario Pennella; Xiaohua Chen; Karl M Koshlap; Michael L VanZile; James C Sacchettini; David P Giedroc
A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins.
Journal of molecular biology 2003;333(4):683-95.
2003: Kazufumi Takano; J Martin Scholtz; James C Sacchettini; C Nick Pace
The contribution of polar group burial to protein stability is strongly context-dependent.
The Journal of biological chemistry 2003;278(34):31790-5.
2003: Fengli Zhang; Christian Lücke; Leslie J Baier; James C Sacchettini; James A Hamilton
Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism.
Biochemistry 2003;42(24):7339-47.
2003: Hossein Razavi; Satheesh K Palaninathan; Evan T Powers; R Luke Wiseman; Hans E Purkey; Nilofar N Mohamedmohaideen; Songpon Deechongkit; Kyle P. Chiang; Maria T A Dendle; James C Sacchettini; Jeffery W Kelly
Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action.
Angewandte Chemie (International ed. in English) 2003;42(24):2758-61.
2003: Laurent Kremer; Lynn Dover; HECTOR MORBIDONI; Catherine Vilchèze; William N Maughan; Alain Baulard; Shiao-Chun Tu; Nadine Honoré; Vojo Deretic; James C Sacchettini; Camille Locht; William R. Jacobs Jr.; Gurdyal S Besra
Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.
The Journal of biological chemistry 2003;278(23):20547-54.
2003: Mack R Kuo; HECTOR MORBIDONI; David Alland; Scott F Sneddon; Brian B Gourlie; Mark M Staveski; Marina Leonard; Jill S Gregory; Andrew D Janjigian; Christopher Yee; James M Musser; Barry Kreiswirth; Hiroyuki Iwamoto; Remo Perozzo; William R. Jacobs Jr.; James C Sacchettini; Fidock David
Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data.
The Journal of biological chemistry 2003;278(23):20851-9.
2003: Kuppan Gokulan; Bernhard Rupp; Martin S Pavelka; William R. Jacobs Jr.; James C Sacchettini
Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis.
The Journal of biological chemistry 2003;278(20):18588-96.
2003: Yoonsang Cho; Vivek Sharma; James C Sacchettini
Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis.
The Journal of biological chemistry 2003;278(10):8333-9.
2003: Vivek Sharma; Arulandu Arockiasamy; Donald Ronning; Christos G Savva; Andreas Holzenburg; Miriam Braunstein; William R. Jacobs Jr.; James C Sacchettini
Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2243-8.
2003: Clare V Smith; Chih-chin Huang; Andras Miczak; David G Russell; James C Sacchettini; Kerstin Höner zu Bentrup
Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis.
The Journal of biological chemistry 2003;278(3):1735-43.
2003: Thomas R Ioerger; James C Sacchettini
TEXTAL system: artificial intelligence techniques for automated protein model building.
Methods in enzymology 2003;374():244-70.
2002: Thomas R Ioerger; James C Sacchettini
Automatic modeling of protein backbones in electron-density maps via prediction of Calpha coordinates.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 12):2043-54.
2002: Paul D Adams; Ralf W Grosse-Kunstleve; Li-Wei Hung; Thomas R Ioerger; Airlie J McCoy; Nigel W Moriarty; Randy J Read; James C Sacchettini; Nicholas K Sauter; Thomas C Terwilliger
PHENIX: building new software for automated crystallographic structure determination.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 11):1948-54.
2002: Michelle R Riley-Lovingshimer; Donald Ronning; James C Sacchettini; Gregory D Reinhart
Reversible ligand-induced dissociation of a tryptophan-shift mutant of phosphofructokinase from Bacillus stearothermophilus.
Biochemistry 2002;41(43):12967-74.
2002: Michelle H. Larsen; Catherine Vilchèze; Laurent Kremer; Gurdyal S Besra; Linda Parsons; Max Salfinger; Leonid Heifets; Manzour H Hazbon; David Alland; James C Sacchettini; William R. Jacobs Jr.
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.
Molecular microbiology 2002;46(2):453-66.
2002: Christoph Eicken; Vivek Sharma; Thomas Klabunde; Matthew B Lawrenz; John M Hardham; Steven J Norris; James C Sacchettini
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi.
The Journal of biological chemistry 2002;277(24):21691-6.
2002: Celia W Goulding; Marcin I Apostol; Daniel H Anderson; Harindarpal S Gill; Clare V Smith; Mack R Kuo; Jin Kuk Yang; Geoffrey S Waldo; Se Won Suh; Radha Chauhan; Avinash Kale; Nandita Bachhawat; Shekhar C Mande; Jodie M Johnston; J Shaun Lott; Edward N Baker; Vickery Arcus; David Leys; Kirsty J McLean; Andrew W Munro; Joel Berendzen; Vivek Sharma; Min S Park; David Eisenberg; James C Sacchettini; Thomas Alber; Bernhard Rupp; William R. Jacobs Jr.; Thomas C Terwilliger
The TB structural genomics consortium: providing a structural foundation for drug discovery.
Current drug targets. Infectious disorders 2002;2(2):121-41.
2002: Remo Perozzo; Mack Kuo; Amar Bir Singh Sidhu; Jacob T Valiyaveettil; Robert Bittman; William R. Jacobs Jr.; Fidock David; James C Sacchettini
Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase.
The Journal of biological chemistry 2002;277(15):13106-14.
2002: James C Sacchettini; Jeffery W Kelly
Therapeutic strategies for human amyloid diseases.
Nature reviews. Drug discovery 2002;1(4):267-75.
2002: Chih-chin Huang; Clare V Smith; Michael S Glickman; William R. Jacobs Jr.; James C Sacchettini
Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis.
The Journal of biological chemistry 2002;277(13):11559-69.
2002: Dong Yang; Lance W Shipman; Charles A Roessner; A Ian Scott; James C Sacchettini
Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily.
The Journal of biological chemistry 2002;277(11):9462-7.
2001: Xin Jiang; C S Smith; H Michael Petrassi; Per Hammarström; Joleen T White; James C Sacchettini; Jeffery W Kelly
An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured.
Biochemistry 2001;40(38):11442-52.
2001: L W Shipman; D Li; Charles A Roessner; A Ian Scott; James C Sacchettini
Crystal structure of precorrin-8x methyl mutase.
Structure (London, England : 1993) 2001;9(7):587-96.
2001: Christoph Eicken; Vivek Sharma; Thomas Klabunde; RT Owens; D S Pikas; Magnus Höök; James C Sacchettini
Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi.
The Journal of biological chemistry 2001;276(13):10010-5.
2001: CT Thomson; Alexis M Kalergis; James C Sacchettini; Stanley G Nathenson
A structural difference limited to one residue of the antigenic peptide can profoundly alter the biological outcome of the TCR-peptide/MHC class I interaction.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3994-7.
2001: James C Sacchettini; Linda G Baum; Curtis Brewer
Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction.
Biochemistry 2001;40(10):3009-15.
2000: James C Sacchettini; Donald Ronning
The mycobacterial antigens 85 complex--from structure to function: response.
Trends in microbiology 2000;8(10):441.
2000: GK Balendiran; F Schnutgen; Giovanna Scapin; T Borchers; N Xhong; K Lim; R Godbout; F Spener; James C Sacchettini
Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein.
The Journal of biological chemistry 2000;275(35):27045-54.
2000: John D McKinney; Kerstin Höner zu Bentrup; Ernesto J Muñoz-Elías; Andras Miczak; Bing Chen; Wai-Tsing Chan; D Swenson; James C Sacchettini; William R. Jacobs Jr.; David G Russell
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.
Nature 2000;406(6797):735-8.
2000: V Sharma; S Sharma; K Hoener zu Bentrup; John D McKinney; David G Russell; William R. Jacobs Jr.; James C Sacchettini
Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.
Nature structural biology 2000;7(8):663-8.
2000: Catherine Vilchèze; HECTOR MORBIDONI; Torin R Weisbrod; H Iwamoto; M Kuo; James C Sacchettini; William R. Jacobs Jr.
Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis.
Journal of bacteriology 2000;182(14):4059-67.
2000: T Holton; Thomas R Ioerger; JA Christopher; James C Sacchettini
Determining protein structure from electron-density maps using pattern matching.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 6):722-34.
2000: Thomas Klabunde; H Michael Petrassi; Vibha B Oza; Prakash Raman; Jeffery W Kelly; James C Sacchettini
Rational design of potent human transthyretin amyloid disease inhibitors.
Nature structural biology 2000;7(4):312-21.
2000: Donald Ronning; Thomas Klabunde; Gurdyal S Besra; Varalakshmi D Vissa; John Belisle; James C Sacchettini
Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.
Nature structural biology 2000;7(2):141-6.
1999: Christoph Eicken; Bernt Krebs; James C Sacchettini
Catechol oxidase - structure and activity.
Current opinion in structural biology 1999;9(6):677-83.
1999: Denise A Rozwarski; Catherine Vilchèze; Michele Sugantino; Robert Bittman; James C Sacchettini
Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate.
The Journal of biological chemistry 1999;274(22):15582-9.
1999: GK Balendiran; J A Molina; Y Xu; J Torres-Martinez; R Stevens; Pamela J Focia; Ann E Eakin; James C Sacchettini; Sydney P Craig
Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding.
Protein science : a publication of the Protein Society 1999;8(5):1023-31.
1999: Thomas R Ioerger; T Holton; JA Christopher; James C Sacchettini
TEXTAL: a pattern recognition system for interpreting electron density maps.
Proceedings / ... International Conference on Intelligent Systems for Molecular Biology ; ISMB. International Conference on Intelligent Systems for Molecular Biology 1999;():130-7.
1998: V Sharma; C Grubmeyer; James C Sacchettini
Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target.
Structure (London, England : 1993) 1998;6(12):1587-99.
1998: Denise A Rozwarski; B M Swami; Curtis Brewer; James C Sacchettini
Crystal structure of the lectin from Dioclea grandiflora complexed with core trimannoside of asparagine-linked carbohydrates.
The Journal of biological chemistry 1998;273(49):32818-25.
1998: Thomas Klabunde; Christoph Eicken; James C Sacchettini; Bernt Krebs
Crystal structure of a plant catechol oxidase containing a dicopper center.
Nature structural biology 1998;5(12):1084-90.
1998: K Lim; S M Owens; L Arnold; James C Sacchettini; Darwin S Linthicum
Crystal structure of monoclonal 6B5 Fab complexed with phencyclidine.
The Journal of biological chemistry 1998;273(44):28576-82.
1998: SA Peterson; T Klabunde; Hilal A Lashuel; Hans E Purkey; James C Sacchettini; Jeffery W Kelly
Inhibiting transthyretin conformational changes that lead to amyloid fibril formation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):12956-60.
1998: A Banerjee; Michele Sugantino; James C Sacchettini; William R. Jacobs Jr.
The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.
Microbiology (Reading, England) 1998;144 ( Pt 10)():2697-704.
1998: M Degano; Steven C Almo; James C Sacchettini; Vern L Schramm
Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor.
Biochemistry 1998;37(18):6277-85.
1998: Denise A Rozwarski; G A Grant; Derek Barton; William R. Jacobs Jr.; James C Sacchettini
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
Science (New York, N.Y.) 1998;279(5347):98-102.
1998: L Miesel; Denise A Rozwarski; James C Sacchettini; William R. Jacobs Jr.
Mechanisms for isoniazid action and resistance.
Novartis Foundation symposium 1998;217():209-20; discussion 220-1.
1998: Thomas Klabunde; S Sharma; A Telenti; William R. Jacobs Jr.; James C Sacchettini
Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing.
Nature structural biology 1998;5(1):31-6.
1997: AC Young; Philippe Valadon; Arturo Casadevall; Matthew D Scharff; James C Sacchettini
The three-dimensional structures of a polysaccharide binding antibody to Cryptococcus neoformans and its complex with a peptide from a phage display library: implications for the identification of peptide mimotopes.
Journal of molecular biology 1997;274(4):622-34.
1997: Laurence R Olsen; A Dessen; D Gupta; Subramanian Sabesan; James C Sacchettini; Curtis Brewer
X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin.
Biochemistry 1997;36(49):15073-80.
1997: GK Balendiran; Joyce C Solheim; AC Young; Ted H Hansen; Stanley G Nathenson; James C Sacchettini
The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6880-5.
1997: F Zhang; Christian Lücke; L J Baier; James C Sacchettini; James A Hamilton
Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit.
Journal of biomolecular NMR 1997;9(3):213-28.
1997: Y Xu; JC Eads; James C Sacchettini; Charles Grubmeyer
Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: rapid phosphoribosyl transfer chemistry.
Biochemistry 1997;36(12):3700-12.
1997: JC Eads; D Ozturk; T B Wexler; Charles Grubmeyer; James C Sacchettini
A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase.
Structure (London, England : 1993) 1997;5(1):47-58.
1996: L C Tarshis; P J Proteau; B A Kellogg; James C Sacchettini; C D Poulter
Regulation of product chain length by isoprenyl diphosphate synthases.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15018-23.
1996: M Irigoyen; Czeslawa Kowal; AC Young; James C Sacchettini; Betty Diamond
Molecular mapping of the 8.12 SLE-associated idiotype specificity at the single amino acid level.
Molecular immunology 1996;33(16):1255-65.
1996: Christian Lücke; F Zhang; H Rüterjans; J A Hamilton; James C Sacchettini
Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein.
Structure (London, England : 1993) 1996;4(7):785-800.
1996: M Degano; D N Gopaul; Giovanna Scapin; Vern L Schramm; James C Sacchettini
Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata.
Biochemistry 1996;35(19):5971-81.
1996: D N Gopaul; S L Meyer; M Degano; James C Sacchettini; Vern L Schramm
Inosine-uridine nucleoside hydrolase from Crithidia fasciculata. Genetic characterization, crystallization, and identification of histidine 241 as a catalytic site residue.
Biochemistry 1996;35(19):5963-70.
1996: Leslie J Baier; Clifton Bogardus; James C Sacchettini
A polymorphism in the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells.
The Journal of biological chemistry 1996;271(18):10892-6.
1996: James C Sacchettini; John S Blanchard
The structure and function of the isoniazid target in M. tuberculosis.
Research in microbiology 1996;147(1-2):36-43.
1995: D H Ozturk; R H Dorfman; Giovanna Scapin; James C Sacchettini; Charles Grubmeyer
Structure and function of Salmonella typhimurium orotate phosphoribosyltransferase: protein complementation reveals shared active sites.
Biochemistry 1995;34(34):10764-70.
1995: D H Ozturk; R H Dorfman; Giovanna Scapin; James C Sacchettini; Charles Grubmeyer
Locations and functional roles of conserved lysine residues in Salmonella typhimurium orotate phosphoribosyltransferase.
Biochemistry 1995;34(34):10755-63.
1995: Giovanna Scapin; D H Ozturk; Charles Grubmeyer; James C Sacchettini
The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate.
Biochemistry 1995;34(34):10744-54.
1995: A Quémard; James C Sacchettini; A Dessen; C Vilcheze; R Bittman; William R. Jacobs Jr.; John S Blanchard
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.
Biochemistry 1995;34(26):8235-41.
1995: A Dessen; D Gupta; S Sabesan; Curtis Brewer; James C Sacchettini
X-ray crystal structure of the soybean agglutinin cross-linked with a biantennary analog of the blood group I carbohydrate antigen.
Biochemistry 1995;34(15):4933-42.
1995: Giovanna Scapin; John S Blanchard; James C Sacchettini
Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase.
Biochemistry 1995;34(11):3502-12.
1995: S G Reddy; James C Sacchettini; John S Blanchard
Expression, purification, and characterization of Escherichia coli dihydrodipicolinate reductase.
Biochemistry 1995;34(11):3492-501.
1995: A Dessen; A Quémard; John S Blanchard; William R. Jacobs Jr.; James C Sacchettini
Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Science (New York, N.Y.) 1995;267(5204):1638-41.
1995: Leslie J Baier; James C Sacchettini; William C Knowler; J Eads; G Paolisso; P Antonio Tataranni; H Mochizuki; Peter H Bennett; Clifton Bogardus; Michal Prochazka
An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.
The Journal of clinical investigation 1995;95(3):1281-7.
1995: AC Young; Stanley G Nathenson; James C Sacchettini
Structural studies of class I major histocompatibility complex proteins: insights into antigen presentation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(1):26-36.
1995: AC Young; W Zhang; James C Sacchettini; Stanley G Nathenson
MHC class I-peptide interactions and TCR recognition.
Cancer surveys 1995;22():17-36.
1994: J C Dewan; Gregory A Grant; James C Sacchettini
Crystal structure of kappa-bungarotoxin at 2.3-A resolution.
Biochemistry 1994;33(44):13147-54.
1994: L C Tarshis; M Yan; C D Poulter; James C Sacchettini
Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution.
Biochemistry 1994;33(36):10871-7.
1994: J C Eads; Giovanna Scapin; Y Xu; Charles Grubmeyer; James C Sacchettini
The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP.
Cell 1994;78(2):325-34.
1994: Bunzo Mikami; M Degano; E J Hehre; James C Sacchettini
Crystal structures of soybean beta-amylase reacted with beta-maltose and maltal: active site components and their apparent roles in catalysis.
Biochemistry 1994;33(25):7779-87.
1994: AC Young; Giovanna Scapin; Arno Kromminga; S B Patel; J H Veerkamp; James C Sacchettini
Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids.
Structure (London, England : 1993) 1994;2(6):523-34.
1994: R G Maatman; M Degano; H T B van Moerkerk; Wil J A van Marrewijk; Dick J Van der Horst; James C Sacchettini; J H Veerkamp
Primary structure and binding characteristics of locust and human muscle fatty-acid-binding proteins.
European journal of biochemistry / FEBS 1994;221(2):801-10.
1994: Giovanna Scapin; Charles Grubmeyer; James C Sacchettini
Crystal structure of orotate phosphoribosyltransferase.
Biochemistry 1994;33(6):1287-94.
1994: AC Young; W Zhang; James C Sacchettini; Stanley G Nathenson
The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection.
Cell 1994;76(1):39-50.
1993: J Eads; James C Sacchettini; Arno Kromminga; J I Gordon
Escherichia coli-derived rat intestinal fatty acid binding protein with bound myristate at 1.5 A resolution and I-FABPArg106-->Gln with bound oleate at 1.74 A resolution.
The Journal of biological chemistry 1993;268(35):26375-85.
1993: J C Dewan; Bunzo Mikami; Masaaki Hirose; James C Sacchettini
Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release.
Biochemistry 1993;32(45):11963-8.
1993: James C Sacchettini; J I Gordon
Rat intestinal fatty acid binding protein. A model system for analyzing the forces that can bind fatty acids to proteins.
The Journal of biological chemistry 1993;268(25):18399-402.
1993: Bunzo Mikami; E J Hehre; M Sato; Y Katsube; Masaaki Hirose; Y Morita; James C Sacchettini
The 2.0-A resolution structure of soybean beta-amylase complexed with alpha-cyclodextrin.
Biochemistry 1993;32(27):6836-45.
1993: Giovanna Scapin; AC Young; Arno Kromminga; J H Veerkamp; J I Gordon; James C Sacchettini
High resolution X-ray studies of mammalian intestinal and muscle fatty acid-binding proteins provide an opportunity for defining the chemical nature of fatty acid: protein interactions.
Molecular and cellular biochemistry 1993;123(1-2):3-13.
1993: Giovanna Scapin; James C Sacchettini; A Dessen; M Bhatia; Charles Grubmeyer
Primary structure and crystallization of orotate phosphoribosyltransferase from Salmonella typhimurium.
Journal of molecular biology 1993;230(4):1304-8.
1992: James C Sacchettini; Giovanna Scapin; D Gopaul; J I Gordon
Refinement of the structure of Escherichia coli-derived rat intestinal fatty acid binding protein with bound oleate to 1.75-A resolution. Correlation with the structures of the apoprotein and the protein with bound palmitate.
The Journal of biological chemistry 1992;267(33):23534-45.
1992: Giuseppe Zanotti; Giovanna Scapin; Paola Spadon; J H Veerkamp; James C Sacchettini
Three-dimensional structure of recombinant human muscle fatty acid-binding protein.
The Journal of biological chemistry 1992;267(26):18541-50.
1992: W Zhang; AC Young; M Imarai; Stanley G Nathenson; James C Sacchettini
Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8403-7.
1992: Giovanna Scapin; J I Gordon; James C Sacchettini
Refinement of the structure of recombinant rat intestinal fatty acid-binding apoprotein at 1.2-A resolution.
The Journal of biological chemistry 1992;267(6):4253-69.
1990: James C Sacchettini; S M Hauft; S L Van Camp; David Cistola; Jeffrey I Gordon
Developmental and structural studies of an intracellular lipid binding protein expressed in the ileal epithelium.
The Journal of biological chemistry 1990;265(31):19199-207.
1990: James C Sacchettini; L J Banaszak; J I Gordon
Expression of rat intestinal fatty acid binding protein in E. coli and its subsequent structural analysis: a model system for studying the molecular details of fatty acid-protein interaction.
Molecular and cellular biochemistry 1990;98(1-2):81-93.
1990: David Cistola; James C Sacchettini; Jeffrey I Gordon
13C NMR studies of fatty acid-protein interactions: comparison of homologous fatty acid-binding proteins produced in the intestinal epithelium.
Molecular and cellular biochemistry 1990;98(1-2):101-10.
1989: James C Sacchettini; Jeffrey I Gordon; L J Banaszak
Refined apoprotein structure of rat intestinal fatty acid binding protein produced in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7736-40.
1989: James C Sacchettini; Jeffrey I Gordon; L J Banaszak
Crystal structure of rat intestinal fatty-acid-binding protein. Refinement and analysis of the Escherichia coli-derived protein with bound palmitate.
Journal of molecular biology 1989;208(2):327-39.
1989: David Cistola; James C Sacchettini; L J Banaszak; M T Walsh; Jeffrey I Gordon
Fatty acid interactions with rat intestinal and liver fatty acid-binding proteins expressed in Escherichia coli. A comparative 13C NMR study.
The Journal of biological chemistry 1989;264(5):2700-10.