David Sachs

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Porcheray F; Wong W; Saidman S L; De Vito J; Girouard T C; Chittenden M; Shaffer J; Tolkoff-Rubin N; Dey B R; Spitzer T R; Colvin R B; Cosimi A B; Kawai T; Sachs D H; Sykes M; Zorn E
B-cell immunity in the context of T-cell tolerance after combined kidney and bone marrow transplantation in humans.
Sachs David H; Sykes Megan; Yamada Kazuhiko
Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy.
Knosalla C; Yazawa K; Behdad A; Bodyak N; Shang H; Bühler L; Houser S; Gollackner B; Griesemer A; Schmitt-Knosalla I; Schuurman H-J; Awwad M; Sachs D H; Cooper D K C; Yamada K; Usheva A; Robson S C
Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation.

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2009: Porcheray F; Wong W; Saidman S L; De Vito J; Girouard T C; Chittenden M; Shaffer J; Tolkoff-Rubin N; Dey B R; Spitzer T R; Colvin R B; Cosimi A B; Kawai T; Sachs D H; Sykes M; Zorn E
B-cell immunity in the context of T-cell tolerance after combined kidney and bone marrow transplantation in humans.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(9):2126-35.
2009: Sachs David H; Sykes Megan; Yamada Kazuhiko
Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy.
Transplant immunology 2009;21(2):101-5.
2009: Knosalla C; Yazawa K; Behdad A; Bodyak N; Shang H; Bühler L; Houser S; Gollackner B; Griesemer A; Schmitt-Knosalla I; Schuurman H-J; Awwad M; Sachs D H; Cooper D K C; Yamada K; Usheva A; Robson S C
Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(5):1006-16.
2009: Sachs David H; Galli Cesare
Genetic manipulation in pigs.
Current opinion in organ transplantation 2009;14(2):148-53.
2009: Weiss M J; Guenther D A; Mezrich J D; Sahara H; Ng C Y; Meltzer A J; Sayre J K; Cochrane M E; Pujara A C; Houser S L; Sachs D H; Rosengard B R; Allan J S; Benichou G; Madsen J C
The indirect alloresponse impairs the induction but not maintenance of tolerance to MHC class I-disparate allografts.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(1):105-13.
2008: Meltzer Andrew J; Weiss Matthew J; Veillette Gregory R; Sahara Hisashi; Ng Choo Y; Cochrane Meghan E; Houser Stuart L; Sachs David H; Rosengard Bruce R; Madsen Joren C; Wain John C; Allan James S
Repetitive gastric aspiration leads to augmented indirect allorecognition after lung transplantation in miniature swine.
Transplantation 2008;86(12):1824-9.
2008: Hisashi Y; Yamada K; Kuwaki K; Tseng Y-L; Dor F J M F; Houser S L; Robson S C; Schuurman H-J; Cooper D K C; Sachs D H; Colvin R B; Shimizu A
Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(12):2516-26.
2008: Griesemer Adam D; Lamattina John C; Okumi Masayoshi; Etter Justin D; Shimizu Akira; Sachs David H; Yamada Kazuhiko
Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation model.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(6):4027-36.
2008: Sogawa Hiroshi; Boskovic Svjetlan; Nadazdin Ognjenka; Abrahamian Greg; Colvin Robert B; Sachs David H; Cosimi A Benedict; Kawai Tatsuo
Limited efficacy and unacceptable toxicity of cyclophosphamide for the induction of mixed chimerism and renal allograft tolerance in cynomolgus monkeys.
Transplantation 2008;86(4):615-9.
2008: Smith R N; Kawai T; Boskovic S; Nadazdin O; Sachs D H; Cosimi A B; Colvin R B
Four stages and lack of stable accommodation in chronic alloantibody-mediated renal allograft rejection in Cynomolgus monkeys.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(8):1662-72.
2008: Traum Avram Z; Kawai Tatsuo; Vacanti Joseph P; Sachs David H; Cosimi A Benedict; Madsen Joren C
The need for tolerance in pediatric organ transplantation.
Pediatrics 2008;121(6):1258-60.
2008: Shimizu Akira; Hisashi Yosuke; Kuwaki Kenji; Tseng Yau-Lin; Dor Frank J M F; Houser Stuart L; Robson Simon C; Schuurman Henk-Jan; Cooper David K C; Sachs David H; Yamada Kazuhiko; Colvin Robert B
Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons.
The American journal of pathology 2008;172(6):1471-81.
2008: Hoerbelt Ruediger; Benjamin Christopher L; Shoji Tsuyoshi; Houser Stuart L; Muniappan Ashok; Hasse Rebecca S; Ledgerwood Levi G; Allan James S; Sachs David H; Madsen Joren C
The effects of tolerance on allograft damage caused by the innate immune system.
Transplantation 2008;85(3):314-22.
2008: Sachs David H
Patents and research: friends or foes?
Surgery 2008;143(2):191-3.
2008: Kawai Tatsuo; Cosimi A Benedict; Spitzer Thomas R; Tolkoff-Rubin Nina; Suthanthiran Manikkam; Saidman Susan L; Shaffer Juanita; Preffer Frederic I; Ding Ruchuang; Sharma Vijay; Fishman Jay A; Dey Bimalangshu; Ko Dicken S C; Hertl Martin; Goes Nelson B; Wong Waichi; Williams Winfred W; Colvin Robert B; Sykes Megan; Sachs David H
HLA-mismatched renal transplantation without maintenance immunosuppression.
The New England journal of medicine 2008;358(4):353-61.
2008: Okumi Masayoshi; Fishbein Jonathan M; Griesemer Adam D; Gianello Pierre R; Hirakata Atsushi; Nobori Shuji; Moran Shannon; Samelson-Jones Emma; Shimizu Akira; Sachs David H; Yamada Kazuhiko
Role of persistence of antigen and indirect recognition in the maintenance of tolerance to renal allografts.
Transplantation 2008;85(2):270-80.
2008: Cho Patricia S; Messina Darin J; Hirsh Erica L; Chi Nina; Goldman Stephanie N; Lo Diana P; Harris Ian R; Popma Sicco H; Sachs David H; Huang Christene A
Immunogenicity of umbilical cord tissue derived cells.
Blood 2008;111(1):430-8.
2007: Shoji Tsuyoshi; Sahara Hisashi; Muniappan Ashok; Guenther Dax A; Wain John C; Houser Stuart L; Bravard Marjory A; Pujara Akshat C; Hasse Rebecca S; Sachs David H; Madsen Joren C; Allan James S
Operational tolerance to class I disparate lungs can be induced despite pretransplant immunization with class I allopeptides.
Transplantation 2007;84(11):1467-73.
2007: Cho Patricia S; Lo Diana P; Wikiel Krzysztof J; Rowland Haley C; Coburn Rebecca C; McMorrow Isabel M; Goodrich Jennifer G; Arn J Scott; Billiter Robert A; Houser Stuart L; Shimizu Akira; Yang Yong-Guang; Sachs David H; Huang Christene A
Establishment of transplantable porcine tumor cell lines derived from MHC-inbred miniature swine.
Blood 2007;110(12):3996-4004.
2007: Hongo David; Hadidi Sima; Damrauer Scott; Garrigue Valerie; Kraft Daniel; Sachs David H; Nikolic Boris; Sykes Megan
Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction.
The Journal of infectious diseases 2007;196(6):900-10.
2007: Sachs David H; Yamada Kazuhiko; Robson Simon C; Fishman Jay A; Shimizu Akira; Colvin Robert B; Sykes Megan
GalT-KO pigs: is the cup half empty or half full?
Transplantation 2007;84(1):12-4.
2007: Shaffer Juanita; Villard Jean; Means Terry K; Alexander Stephen; Dombkowski David; Dey Bimalangshu R; McAfee Steven; Ballen Karen K; Saidman Susan; Preffer Frederic I; Sachs David H; Spitzer Thomas R; Sykes Megan
Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine.
Experimental hematology 2007;35(7):1140-52.
2007: Nguyen Bao-Ngoc H; Azimzadeh Agnes M; Zhang Tianshu; Wu Guosheng; Schuurman Henk-Jan; Sachs David H; Ayares David; Allan James S; Pierson Richard N
Life-supporting function of genetically modified swine lungs in baboons.
The Journal of thoracic and cardiovascular surgery 2007;133(5):1354-63.
2007: Koyama I; Nadazdin O; Boskovic S; Ochiai T; Smith R N; Sykes M; Sogawa H; Murakami T; Strom T B; Colvin R B; Sachs D H; Benichou G; Cosimi A B; Kawai T
Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(5):1055-61.
2007: Doucette Karen; Dor Frank J M F; Wilkinson Robert A; Martin Stanley I; Huang Christene A; Cooper David K C; Sachs David H; Fishman Jay A
Gene expression of porcine lymphotrophic herpesvirus-1 in miniature Swine with posttransplant lymphoproliferative disorder.
Transplantation 2007;83(1):87-90.
2007: Vallabhajosyula Prashanth; Griesemer Adam; Yamada Kazuhiko; Sachs David H
Vascularized composite islet-kidney transplantation in a miniature swine model.
Cell biochemistry and biophysics 2007;48(2-3):201-7.
2006: Horner B M; Cina R A; Wikiel K J; Lima B; Ghazi A; Lo D P; Yamada K; Sachs D H; Huang C A
Predictors of organ allograft tolerance following hematopoietic cell transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(12):2894-902.
2006: Shoji T; Sahara H; Muniappan A; Guenther D A; Houser S L; Pujara A C; Bravard M A; Wain J C; Sachs D H; Madsen J C; Allan J S
An MHC class II disparity raises the threshold for tolerance induction in pulmonary allografts in miniature swine.
Transplantation proceedings 2006;38(10):3268-70.
2006: Sahara H; Shoji T; Ng C Y; Weiss M J; Muniappan A; Guenther D A; Houser S L; Pujara A C; Sayre J K; Wain J C; Sachs D H; Madsen J C; Allan J S
The role of indirect recognition of MHC class I and II allopeptides in a fully mismatched miniature swine model of lung transplantation.
Transplantation proceedings 2006;38(10):3256-8.
2006: Sahara H; Weiss M J; Ng C Y; Houser S L; Pujara A C; Sayre J K; Wain J C; Sachs D H; Madsen J C; Allan J S
Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine.
Transplantation proceedings 2006;38(10):3253-5.
2006: Nobori Shuji; Shimizu Akira; Okumi Masayoshi; Samelson-Jones Emma; Griesemer Adam; Hirakata Atsushi; Sachs David H; Yamada Kazuhiko
Thymic rejuvenation and the induction of tolerance by adult thymic grafts.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19081-6.
2006: Boskovic Svjetlan; Kawai Tatsuo; Smith Rex-Neal; Wee Siew-Lin; Nadazdin Ognjenka; Koyama Ichiro; Saidman Susan; Cardarelli Francesca; Elias Nahel; Sykes Megan; Strom Terry; Colvin Robert B; Sachs David H; Cosimi A Benedict
Monitoring antidonor alloantibodies as a predictive assay for renal allograft tolerance/long-term observations in nonhuman primates.
Transplantation 2006;82(6):819-25.
2006: Fudaba Y; Spitzer T R; Shaffer J; Kawai T; Fehr T; Delmonico F; Preffer F; Tolkoff-Rubin N; Dey B R; Saidman S L; Kraus A; Bonnefoix T; McAfee S; Power K; Kattleman K; Colvin R B; Sachs D H; Cosimi A B; Sykes M
Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(9):2121-33.
2006: Wong Banny S; Yamada Kazuhiko; Okumi Masayoshi; Weiner Joshua; O'Malley Patricia E; Tseng Yau-Lin; Dor Frank J M F; Cooper David K C; Saidman Susan L; Griesemer Adam; Sachs David H
Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase gene-knockout miniature swine in patients on transplantation waiting lists.
Transplantation 2006;82(3):314-9.
2006: Smith R N; Kawai T; Boskovic S; Nadazdin O; Sachs D H; Cosimi A B; Colvin R B
Chronic antibody mediated rejection of renal allografts: pathological, serological and immunologic features in nonhuman primates.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(8):1790-8.
2006: Tseng Yau-Lin; Moran Kathleen; Dor Frank J M F; Sanderson Todd M; Li Wei; Lancos Courtney J; Schuurman Henk-Jan; Sachs David H; Cooper David K C
Elicited antibodies in baboons exposed to tissues from alpha1,3-galactosyltransferase gene-knockout pigs.
Transplantation 2006;81(7):1058-62.
2006: Yamamoto Shin; Teranishi Katsuhito; Kamano Chisako; Samelson-Jones Emma; Arakawa Hitoshi; Nobori Shuji; Okumi Masayoshi; Houser Stuart; Shimizu Akira; Sachs David H; Yamada Kazuhiko
Role of the thymus in transplantation tolerance in miniature swine: V. Deficiency of the graft-to-thymus pathway of tolerance induction in recipients of cardiac transplants.
Transplantation 2006;81(4):607-13.
2006: Nobori Shuji; Samelson-Jones Emma; Shimizu Akira; Hisashi Yosuke; Yamamoto Shin; Kamano Chisako; Teranishi Katsuhito; Vagefi Parsia A; Nuhn Mathew; Okumi Masayoshi; Wong Banny; Houser Stuart; Sachs David H; Yamada Kazuhiko
Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swine.
Transplantation 2006;81(1):26-35.
2006: Kawai Tatsuo; Sachs David H; Sykes Megan; Spitzer Thomas; Tolkoff-Rubin Nina; Saidman Susan; Ko Dicken; Dey Bimalangshu; Colvin Rober B; Cosimi A Benedict
My most interesting cases.
Clinical transplants 2006;():580-2.
2005: Yamamoto Shin; Lavelle John M; Vagefi Parsia A; Arakawa Hitoshi; Samelson-Jones Emma; Moran Shannon; Teranishi Katsuhito; Kamano Chisako; Fishman Jay; Awwad Michel; Neville David M; Shimizu Akira; Sykes Megan; Sachs David H; Yamada Kazuhiko
Vascularized thymic lobe transplantation in a pig-to-baboon model: a novel strategy for xenogeneic tolerance induction and T-cell reconstitution.
Transplantation 2005;80(12):1783-90.
2005: Tseng Yau-Lin; Kuwaki Kenji; Dor Frank J M F; Shimizu Akira; Houser Stuart; Hisashi Yosuke; Yamada Kazuhiko; Robson Simon C; Awwad Michel; Schuurman Henk-Jan; Sachs David H; Cooper David K C
alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months.
Transplantation 2005;80(10):1493-500.
2005: Mathes David W; Solari Mario G; Randolph Mark A; Gazelle G Scott; Yamada Kazuhiko; Huang Christene A; Sachs David H; Lee W P Andrew
Long-term acceptance of renal allografts following prenatal inoculation with adult bone marrow.
Transplantation 2005;80(9):1300-8.
2005: Hoerbelt Ruediger; Johnston Douglas R; Shoji Tsuyoshi; Houser Stuart L; Hasse Rebecca S; Ledgerwood Levi G; Iribarne Alexander; Allan James S; Sayegh Mohamed H; Sachs David H; Madsen Joren C
Combination treatment with donor-specific transfusions and cyclosporine a induces long-term survival of cardiac allografts in miniature Swine.
Transplantation 2005;80(9):1275-82.
2005: Kuwaki K; Tseng Y-L; Dor F J M F; Shimizu A; Sachs D H; Cooper D K C
Localized myocardial infarction following pig-to-baboon heart transplantation.
Xenotransplantation 2005;12(6):489-91.
2005: Rodríguez-Barbosa José-Ignacio; Haller Gary W; Zhao Guiling; Sachs David H; Sykes Megan
Host thymectomy and cyclosporine lead to unstable skin graft tolerance after class I mismatched allogeneic neonatal thymic transplantation in mice.
Transplant immunology 2005;15(1):25-33.
2005: Shimizu Akira; Yamada Kazuhiko; Yamamoto Shin; Lavelle John M; Barth Rolf N; Robson Simon C; Sachs David H; Colvin Robert B
Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts.
Journal of the American Society of Nephrology : JASN 2005;16(9):2732-45.
2005: Johnston Douglas R; Muniappan Ashok; Hoerbelt Ruediger; Guenther Dax A; Shoji Tsuyoshi; Houser Stuart L; Sachs David H; Madsen Joren C
Heart and en-bloc thymus transplantation in miniature swine.
The Journal of thoracic and cardiovascular surgery 2005;130(2):554-9.
2005: Shoji Tsuyoshi; Wain John C; Houser Stuart L; Benjamin Louis C; Johnston Douglas R; Hoerbelt Ruediger; Hasse Rebecca S; Lee Richard S; Muniappan Ashok; Guenther Dax A; Bravard Marjory A; Ledgerwood Levi G; Sachs David H; Sayegh Mohamed H; Madsen Joren C; Allan James S
Indirect recognition of MHC class I allopeptides accelerates lung allograft rejection in miniature swine.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(7):1626-34.
2005: Mezrich Joshua D; Benjamin Louis C; Sachs Jessica A; Houser Stuart L; Vagefi Parsia A; Sachs David H; Madsen Joren C; Yamada Kazuhiko
Role of the thymus and kidney graft in the maintenance of tolerance to heart grafts in miniature swine.
Transplantation 2005;79(12):1663-73.
2005: Lee Patricia W; Cina Robert A; Randolph Mark A; Arellano Ron; Goodrich Jennifer; Rowland Haley; Huang Christene A; Sachs David H; Kim Heung Bae
In utero bone marrow transplantation induces kidney allograft tolerance across a full major histocompatibility complex barrier in Swine.
Transplantation 2005;79(9):1084-90.
2005: Lee Patricia W; Cina Robert A; Randolph Mark A; Goodrich Jennifer; Rowland Haley; Arellano Ron; Kim Heung Bae; Sachs David H; Huang Christene A
Stable multilineage chimerism across full MHC barriers without graft-versus-host disease following in utero bone marrow transplantation in pigs.
Experimental hematology 2005;33(3):371-9.
2005: Schroeder C; Allan J S; Nguyen B-N; Wu G; Zhang T; Azimzadeh A M; Madsen J C; Schuurman H-J; Sachs D H; Pierson R N
Hyperacute rejection is attenuated in GalT knockout swine lungs perfused ex vivo with human blood.
Transplantation proceedings 2005;37(1):512-3.
2005: Dor F J M F; Kuwaki K; Tseng Y-L; Shimizu A; Houser S L; Yamada K; Hawley R J; Patience C; Awwad M; Fishman J A; Robson S C; Sachs D H; Schuurman H-J; Cooper D K C
Potential of aspirin to inhibit thrombotic microangiopathy in alpha1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons.
Transplantation proceedings 2005;37(1):489-90.
2005: Shoji T; Muniappan A; Guenther D A; Wain J C; Houser S L; Hoerbelt R; Benjamin L C; Hasse R S; Bravard M A; Sachs D H; Madsen J C; Allan J S
Long-term acceptance of porcine pulmonary allografts without chronic rejection.
Transplantation proceedings 2005;37(1):72-4.
2005: Tseng Yau-Lin; Sachs David H; Cooper David K C
Porcine hematopoietic progenitor cell transplantation in nonhuman primates: a review of progress.
Transplantation 2005;79(1):1-9.
2005: Kuwaki Kenji; Tseng Yau-Lin; Dor Frank J M F; Shimizu Akira; Houser Stuart L; Sanderson Todd M; Lancos Courtney J; Prabharasuth Derek D; Cheng Jane; Moran Kathleen; Hisashi Yosuke; Mueller Nicolas; Yamada Kazuhiko; Greenstein Julia L; Hawley Robert J; Patience Clive; Awwad Michel; Fishman Jay A; Robson Simon C; Schuurman Henk-Jan; Sachs David H; Cooper David K C
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.
Nature medicine 2005;11(1):29-31.
2005: Yamada Kazuhiko; Yazawa Koji; Shimizu Akira; Iwanaga Takehiro; Hisashi Yosuke; Nuhn Matthew; O'Malley Patricia; Nobori Shuji; Vagefi Parsia A; Patience Clive; Fishman Jay; Cooper David K C; Hawley Robert J; Greenstein Julia; Schuurman Henk-Jan; Awwad Michel; Sykes Megan; Sachs David H
Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.
Nature medicine 2005;11(1):32-4.
2005: Mueller Nicolas J; Kuwaki Kenji; Knosalla Christoph; Dor Frank J M F; Gollackner Bernd; Wilkinson Robert A; Arn Scott; Sachs David H; Cooper David K C; Fishman Jay A
Early weaning of piglets fails to exclude porcine lymphotropic herpesvirus.
Xenotransplantation 2005;12(1):59-62.
2004: Eguchi Hiroshi; Knosalla Christoph; Lan Ping; Cheng Jane; Diouf Bintou; Wang Lan; Abe Masahiro; Schuurman Henk-Jan; Sachs David H; Sykes Megan; Cooper David K C; Yang Yong-Guang
T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model.
Transplantation 2004;78(11):1609-17.
2004: Mueller Nicolas J; Kuwaki Kenji; Dor Frank J M F; Knosalla Christoph; Gollackner Bernd; Wilkinson Robert A; Sachs David H; Cooper David K C; Fishman Jay A
Reduction of consumptive coagulopathy using porcine cytomegalovirus-free cardiac porcine grafts in pig-to-primate xenotransplantation.
Transplantation 2004;78(10):1449-53.
2004: Kawai Tatsuo; Sogawa Hiroshi; Boskovic Svetlan; Abrahamian Gregory; Smith Rex-Neal; Wee Siew-Lin; Andrews David; Nadazdin Ognjenka; Koyama Ichiro; Sykes Megan; Winn Henry J; Colvin Robert B; Sachs David H; Cosimi A Benedict
CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(9):1391-8.
2004: Cho Patricia S; Mueller Nicolas J; Cameron Andrew M; Cina Robert A; Coburn Rebecca C; Hettiaratchy Shehan; Melendy Elizabeth; Neville David M; Patience Clive; Fishman Jay A; Sachs David H; Huang Christene A
Risk factors for the development of post-transplant lymphoproliferative disorder in a large animal model.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(8):1274-82.
2004: Dor Frank J M F; Tseng Yau-Lin; Cheng Jane; Moran Kathleen; Sanderson Todd M; Lancos Courtney J; Shimizu Akira; Yamada Kazuhiko; Awwad Michel; Sachs David H; Hawley Robert J; Schuurman Henk-Jan; Cooper David K C
alpha1,3-Galactosyltransferase gene-knockout miniature swine produce natural cytotoxic anti-Gal antibodies.
Transplantation 2004;78(1):15-20.
2004: Tseng Y-L; Dor F J M F; Kuwaki K; Ryan D; Wood J; Denaro M; Giovino M; Yamada K; Hawley R; Patience C; Schuurman H-J; Awwad M; Sachs D H; Cooper D K C
Bone marrow transplantation from alpha1,3-galactosyltransferase gene-knockout pigs in baboons.
Xenotransplantation 2004;11(4):361-70.
2004: Knosalla C; Ryan D J J; Moran K; Gollackner B; Schuler W; Sachs D H; Awwad M; Schuurman H-J; Cooper D K C
Initial experience with the human anti-human CD154 monoclonal antibody, ABI793, in pig-to-baboon xenotransplantation.
Xenotransplantation 2004;11(4):353-60.
2004: Kolber-Simonds Donna; Lai Liangxue; Watt Steven R; Denaro Maria; Arn Scott; Augenstein Monica L; Betthauser Jeffery; Carter David B; Greenstein Julia L; Hao Yanhong; Im Gi-Sun; Liu Zhonghua; Mell Greg D; Murphy Clifton N; Park Kwang-Wook; Rieke August; Ryan David J J; Sachs David H; Forsberg Erik J; Prather Randall S; Hawley Robert J
Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(19):7335-40.
2004: Mezrich Josh; Yamada Kazuhiko; Sachs David H; Madsen Joren C
Regulatory T cells generated by the kidney may mediate the beneficial immune effects of combining kidney with heart transplantation.
Surgery 2004;135(5):473-8.
2004: Mueller Nicolas J; Livingston Christine; Knosalla Christoph; Barth Rolf N; Yamamoto Shin; Gollackner Bernd; Dor Frank J M F; Buhler Leo; Sachs David H; Yamada Kazuhiko; Cooper David K C; Fishman Jay A
Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation.
The Journal of infectious diseases 2004;189(9):1628-33.
2004: Lan Ping; Wang Lan; Diouf Bintou; Eguchi Hiroshi; Su Hui; Bronson Roderick; Sachs David H; Sykes Megan; Yang Yong-Guang
Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism.
Blood 2004;103(10):3964-9.
2004: Vagefi Parsia A; Ierino Francesco L; Gianello Pierre R; Shimizu Akira; Kamano Chisako; Sachs David H; Yamada Kazuhiko
Role of the thymus in transplantation tolerance in miniature Swine: IV. The thymus is required during the induction phase, but not the maintenance phase, of renal allograft tolerance.
Transplantation 2004;77(7):979-85.
2004: Cosimi A Benedict; Sachs David H
Mixed chimerism and transplantation tolerance.
Transplantation 2004;77(6):943-6.
2004: Kamano Chisako; Vagefi Parsia A; Kumagai Naoki; Yamamoto Shin; Barth Rolf N; LaMattina John C; Moran Shannon G; Sachs David H; Yamada Kazuhiko
Vascularized thymic lobe transplantation in miniature swine: thymopoiesis and tolerance induction across fully MHC-mismatched barriers.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(11):3827-32.
2004: Wood James C; Quinn Gary; Suling Kristen M; Oldmixon Beth A; Van Tine Brian A; Cina Robert; Arn Scott; Huang Christine A; Scobie Linda; Onions David E; Sachs David H; Schuurman Henk-Jan; Fishman Jay A; Patience Clive
Identification of exogenous forms of human-tropic porcine endogenous retrovirus in miniature Swine.
Journal of virology 2004;78(5):2494-501.
2004: Kuwaki Kenji; Knosalla Christoph; Dor Frank J M F; Gollackner Bernd; Tseng Yau-Lin; Houser Stuart; Mueller Nicolas; Prabharasuth Derek; Alt Amy; Moran Kathy; Cheng Jane; Behdad Amir; Sachs David H; Fishman Jay A; Schuurman Henk-Jan; Awwad Michel; Cooper David K C
Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(3):363-72.
2004: Hettiaratchy Shehan; Melendy Elizabeth; Randolph Mark A; Coburn Rebecca C; Neville David M; Sachs David H; Huang Christene A; Lee W P Andrew
Tolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine.
Transplantation 2004;77(4):514-21.
2004: Koyama Ichiro; Kawai Tatsuo; Andrews David; Boskovic Svetlan; Nadazdin Ognjenka; Wee Siew Lin; Sogawa Hiroshi; Wu Dong-Li; Smith R Neal; Colvin Robert B; Sachs David H; Cosimi A Benedict
Thrombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in nonhuman primates.
Transplantation 2004;77(3):460-2.
2004: Wu Anette; Yamada Kazuhiko; Baron Christophe; Mathes David W; Monajati Leila M; Vagefi Parsia A; Sachs David H
Detection of regulatory cells as an assay for allograft tolerance in miniature swine.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2004;23(2):210-7.
2004: Houser Stuart L; McMorrow Isabel M; LeGuern Christian; Schwarze Margaret L; Fuchimoto Yasuli; Sachs David H; Madsen Joren C
Histomorphometric comparison of cardiac allograft vasculopathy in miniature swine.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2004;23(1):50-60.
2004: Menard Matthew T; Schwarze Margaret L; Allan James S; Johnston Douglas R; Mawulawde Kwabena; Shimizu Akira; Yamada Kazuhiko; Houser Stuart L; Allison Kenneth S; Sachs David H; Madsen Joren C
Composite "thymoheart" transplantation improves cardiac allograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(1):79-86.
2004: Quinn Gary; Wood James; Suling Kristen; Arn Scott; Sachs David H; Schuurman Henk-Jan; Patience Clive
Genotyping of porcine endogenous retroviruses from a family of miniature swine.
Journal of virology 2004;78(1):314-9.
2003: Knosalla Christoph; Gollackner Bernd; Bühler Leo; Mueller Nicolas J; Houser Stuart; Mauiyyedi Shamila; Sachs David H; Robson Simon C; Fishman Jay; Schuurman Henk-Jan; Awwad Michel; Cooper David K C
Correlation of biochemical and hematological changes with graft failure following pig heart and kidney transplantation in baboons.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(12):1510-9.
2003: Gollackner Bernd; Knosalla Christoph; Houser Stuart; Mauiyyedi Shamila; Buhler Leo; Kawai Tatsuo; Duggan Mike; Sachs David H; Awwad Michel; Cooper David K C
Pig kidney transplantation in baboons treated intravenously with a bovine serum albumin-Galalpha1-3Gal conjugate.
Xenotransplantation 2003;10(6):606-14.
2003: Lima Brian; Gleit Zachary L; Cameron Andrew M; Germana Sharon; Murphy Michael C; Consorti Robert; Chang Qing; Down Julian D; LeGuern Christian; Sachs David H; Huang Christene A
Engraftment of quiescent progenitors and conversion to full chimerism after nonmyelosuppressive conditioning and hematopoietic cell transplantation in miniature swine.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2003;9(9):571-82.
2003: Le Guern Annie C; Giovino Maria A; Abe Masahiro; Theodore Pierre R; Qi Jin; Down Julian D; Sachs David H; Sykes Megan; Yang Yong-Guang
Stem cell activity of porcine c-kit+ hematopoietic cells.
Experimental hematology 2003;31(9):833-40.
2003: Mezrich Joshua D; Kesselheim Jared A; Johnston Douglas R; Yamada Kazuhiko; Sachs David H; Madsen Joren C
The role of regulatory cells in miniature swine rendered tolerant to cardiac allografts by donor kidney cotransplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(9):1107-15.
2003: Mueller Nicolas J; Sulling Kristen; Gollackner Bernd; Yamamoto Shin; Knosalla Christoph; Wilkinson Robert A; Kaur Amitinder; Sachs David H; Yamada Kazuhiko; Cooper David K C; Patience Clive; Fishman Jay A
Reduced efficacy of ganciclovir against porcine and baboon cytomegalovirus in pig-to-baboon xenotransplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(9):1057-64.
2003: Mezrich Joshua D; Yamada Kazuhiko; Lee Richard S; Mawulawde Kwabena; Benjamin Louis C; Schwarze Margaret L; Maloney Michaella E; Amoah Hannah C; Houser Stuart L; Sachs David H; Madsen Joren C
Induction of tolerance to heart transplants by simultaneous cotransplantation of donor kidneys may depend on a radiation-sensitive renal-cell population.
Transplantation 2003;76(4):625-31.
2003: Yamada Kazuhiko; Vagefi Parsia A; Utsugi Ryu; Kitamura Hiroshi; Barth Rolf N; LaMattina John C; Sachs David H
Thymic transplantation in miniature swine: III. Induction of tolerance by transplantation of composite thymokidneys across fully major histocompatibility complex-mismatched barriers.
Transplantation 2003;76(3):530-6.
2003: Wu Anette; Yamada Kazuhiko; Ierino Francesco L; Vagefi Parsia A; Sachs David H
Regulatory mechanism of peripheral tolerance: in vitro evidence for dominant suppression of host responses during the maintenance phase of tolerance to renal allografts in miniature swine.
Transplant immunology 2003;11(3-4):367-74.
2003: Teranishi Katsuhito; Alwayn Ian P J; Bühler Leo; Gollackner Bernd; Knosalla Christoph; Huck Jennifer; Duthaler Rudolf; Katopodis Andreas; Sachs David H; Schuurman Henk-Jan; Awwad Michel; Cooper David K C
Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons.
Xenotransplantation 2003;10(4):357-67.
2003: Sachs David H
Tolerance: of mice and men.
The Journal of clinical investigation 2003;111(12):1819-21.
2003: Gollackner Bernd; Mueller Nicolas J; Houser Stuart; Qawi Imrana; Soizic Daniel; Knosalla Christoph; Buhler Leo; Dor Frank J M F; Awwad Michel; Sachs David H; Cooper David K C; Robson Simon C; Fishman Jay A
Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation.
Transplantation 2003;75(11):1841-7.
2003: Zhao Yong; Rodriguez-Barbosa Jose-Ignacio; Shimizu Akira; Sachs David H; Sykes Megan
Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: evidence for failure of regulatory mechanisms suppressing autoimmunity.
Transplantation 2003;75(11):1832-40.
2003: Gollackner B; Dor F J M F; Knosalla C; Buhler L; Duggan M; Huang C A; Houser S L; Sachs D H; Kawai T; Ko D S C; Cooper D K C
Spleen transplantation in miniature swine: surgical technique and results in major histocompatibility complex-matched donor and recipient pairs.
Transplantation 2003;75(11):1799-806.
2003: Spitzer Thomas R; McAfee Steven L; Dey Bimalangshu R; Colby Christine; Hope James; Grossberg Howard; Preffer Frederic; Shaffer Juanita; Alexander Stephen I; Sachs David H; Sykes Megan
Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies.
Transplantation 2003;75(10):1748-51.
2003: Barth Rolf N; Yamamoto Shin; LaMattina John C; Kumagai Naoki; Kitamura Hiroshi; Vagefi Parsia A; Awwad Michel; Colvin Robert B; Cooper David K C; Sykes Megan; Sachs David H; Yamada Kazuhiko
Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness.
Transplantation 2003;75(10):1615-24.
2003: Dey Bimalangshu R; McAfee Steven; Colby Christine; Sackstein Robert; Saidman Susan; Tarbell Nancy; Sachs David H; Sykes Megan; Spitzer Thomas R
Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2003;9(5):320-9.
2003: Mezrich Joshua D; Haller Gary W; Arn J Scott; Houser Stuart L; Madsen Joren C; Sachs David H
Histocompatible miniature swine: an inbred large-animal model.
Transplantation 2003;75(6):904-7.
2003: Wu Anette; Yamada Kazuhiko; Neville David M; Awwad Michel; Wain John C; Shimizu Akira; Gojo Satoshi; Kitamura Hiroshi; Colvin Robert B; Cooper David K C; Sykes Megan; Sachs David H
Xenogeneic thymus transplantation in a pig-to-baboon model.
Transplantation 2003;75(3):282-91.
2003: Mathes David W; Randolph Mark A; Solari Mario G; Nazzal Jamal A; Nielsen G Petur; Arn J Scott; Sachs David H; Lee W P Andrew
Split tolerance to a composite tissue allograft in a swine model.
Transplantation 2003;75(1):25-31.
2003: Shimada Hideaki; Germana Sharon; Hayashi Hideki; Sachs David H; LeGuern Christian
Expression of MHC class II DQ alpha/beta heterodimers from recombinant polycistronic retroviral genomes.
Surgery today 2003;33(3):183-9.
2002: Gleit Zachary L; Fuchimoto Yasushi; Yamada Kazuhiko; Melendy Elizabeth; Scheier-Dolberg Rachel; Monajati Leila; Coburn Rebecca C; Neville David M; Sachs David H; Huang Christene A
Variable relationship between chimerism and tolerance after hematopoietic cell transplantation without myelosuppressive conditioning.
Transplantation 2002;74(11):1535-44.
2002: Gleit Zachary L; Cameron Andrew M; Fuchimoto Yasushi; Melendy Elizabeth; Monajati Leila; Coburn Rebecca C; Sachs David H; Huang Christene A
Persistent chimerism despite antidonor MHC in vitro responses in miniature swine following allogeneic hematopoietic cell transplantation.
Transplantation 2002;74(9):1260-6.
2002: Kumagai Naoki; O'Neil John J; Barth Rolf N; LaMattina John C; Utsugi Ryu; Moran Shannon G; Yamamoto Shin; Vagefi Parsia A; Kitamura Hiroshi; Kamano Chisako; Sachs David H; Yamada Kazuhiko
Vascularized islet-cell transplantation in miniature swine. I. Preparation of vascularized islet kidneys.
Transplantation 2002;74(9):1223-30.
2002: Bagley Jessamyn; Tian Chaorui; Sachs David H; Iacomini John
T cells mediate resistance to genetically modified bone marrow in lethally irradiated recipients.
Transplantation 2002;74(10):1454-60.
2002: Bühler Leo H; Spitzer Thomas R; Sykes Megan; Sachs David H; Delmonico Francis L; Tolkoff-Rubin Nina; Saidman Susan L; Sackstein Robert; McAfee Steven; Dey Bimalangshu; Colby Christine; Cosimi A Benedict
Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease.
Transplantation 2002;74(10):1405-9.
2002: Teranishi K; Alwayn I P J; Bühler L; Gollackner B; Knosalla C; Correa L; Down J D; White-Scharf M E; Sachs D H; Duthaler R; Katopodis A; Awwad M; Cooper D K C
Depletion of natural anti-pig antibodies by the continuous infusion of oligosaccharides in a pig-to-baboon model.
Transplantation proceedings 2002;34(7):2757-8.
2002: Kumagai Naoki; LaMattina John C; Kamano Chisako; Vagefi Parsia A; Barth Rolf N; O'Neil John J; Yamamoto Shin; Moran Shannon G; Utsugi Ryu; Sachs David H; Yamada Kazuhiko
Vascularized islet cell transplantation in miniature Swine: islet-kidney allografts correct the diabetic hyperglycemia induced by total pancreatectomy.
Diabetes 2002;51(11):3220-8.
2002: Bühler Leo; Kurilla-Mahon Barbara; Chang Qing; Abraham Sonny; Alwayn Ian P J; Appel James Z; Newman Dawne; Awwad Michel; White-Scharf Mary E; Sackstein Roberto; Sachs David H; Cooper David K C; Down Julian D
Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells.
Transplantation 2002;74(8):1159-66.
2002: Haller Gary W; Lima Brian; Kunisaki Shaun M; Germana Sharon; Leguern Christian; Huang Christene A; Sachs David H
MHC alloantigens elicit secondary, but not primary, indirect in vitro proliferative responses.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3613-21.
2002: Mapara Markus Y; Kim Yong-Mi; Wang Sheng-Ping; Bronson Roderick; Sachs David H; Sykes Megan
Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells.
Blood 2002;100(5):1903-9.
2002: Kunisaki Shaun M; Haller Gary W; Shimizu Akira; Kitamura Hiroshi; Colvin Robert B; Sachs David H
Autologous graft-versus-host disease in a porcine bone marrow transplant model.
Transplantation 2002;74(4):465-71.
2002: Heinz Matthew; Huang Christene A; Emery David W; Giovino Maria A; LeGuern Annie; Kurilla-Mahon Barbara; Theodore Pierre; Arn J Scott; Sykes Megan; Mulligan Richard; Down Julian D; Sachs David H; Goodell Margaret A
Use of CD9 expression to enrich for porcine hematopoietic progenitors.
Experimental hematology 2002;30(7):809-15.
2002: Mathes David W; Randolph Mark A; Bourget Judy L; Nielsen G Petur; Ferrera Vincent R; Arn J Scott; Sachs David H; Lee W P Andrew
Recipient bone marrow engraftment in donor tissue after long-term tolerance to a composite tissue allograft.
Transplantation 2002;73(12):1880-5.
2002: Shimizu Akira; Yamada Kazuhiko; Sachs David H; Colvin Robert B
Mechanisms of chronic renal allograft rejection. II. Progressive allograft glomerulopathy in miniature swine.
Laboratory investigation; a journal of technical methods and pathology 2002;82(6):673-86.
2002: Mezrich Joshua D; Sachs David H; Madsen Joren C
Combined heart and kidney transplantation: are two organs better than one?
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2002;21(6):714-6.
2002: Bagley Jessamyn; Tian Chaorui; Sachs David H; Iacomini John
Induction of T-cell tolerance to an MHC class I alloantigen by gene therapy.
Blood 2002;99(12):4394-9.
2002: Schmidtko Jan; Wang Ruojie; Wu Chin-Lee; Mauiyyedi Shamila; Harris Nancy L; Della Pelle Patricia; Brousaides Nicole; Zagachin Luba; Ferry Judith A; Wang Fred; Kawai Tatsuo; Sachs David H; Cosimi Benedict A; Colvin Robert B
Posttransplant lymphoproliferative disorder associated with an Epstein-Barr-related virus in cynomolgus monkeys.
Transplantation 2002;73(9):1431-9.
2002: Mueller Nicolas J; Barth Rolf N; Yamamoto Shin; Kitamura Hiroshi; Patience Clive; Yamada Kazuhiko; Cooper David K C; Sachs David H; Kaur Amitinder; Fishman Jay A
Activation of cytomegalovirus in pig-to-primate organ xenotransplantation.
Journal of virology 2002;76(10):4734-40.
2002: Shimizu Akira; Yamada Kazuhiko; Sachs David H; Colvin Robert B
Persistent rejection of peritubular capillaries and tubules is associated with progressive interstitial fibrosis.
Kidney international 2002;61(5):1867-79.
2002: Goltz Michael; Ericsson Thomas; Patience Clive; Huang Christene A; Noack Stefanie; Sachs David H; Ehlers Bernhard
Sequence analysis of the genome of porcine lymphotropic herpesvirus 1 and gene expression during posttransplant lymphoproliferative disease of pigs.
Virology 2002;294(2):383-93.
2002: LaMattina John C; Kumagai Naoki; Barth Rolf N; Yamamoto Shin; Kitamura Hiroshi; Moran Shannon G; Mezrich Joshua D; Sachs David H; Yamada Kazuhiko
Vascularized thymic lobe transplantation in miniature swine: I. Vascularized thymic lobe allografts support thymopoiesis.
Transplantation 2002;73(5):826-31.
2002: McMorrow Isabel M; Buhler Leo; Treter Sarah; Neethling Francisca A; Alwayn Ian P J; Comrack Christopher A; Kitamura Hiroshi; Awwad Michel; DerSimonian Harout; Cooper David K C; Sachs David H; LeGuern Christian
Modulation of the in vivo primate anti-Gal response through administration of anti-idiotypic antibodies.
Xenotransplantation 2002;9(2):106-14.
2002: Allan James S; Wain John C; Schwarze Margaret L; Houser Stuart L; Benjamin Louis C; Madsen Joren C; Sachs David H
Modeling chronic lung allograft rejection in miniature swine.
Transplantation 2002;73(3):447-53.
2002: Bühler L; Deng S; O'Neil J; Kitamura H; Koulmanda M; Baldi A; Rahier J; Alwayn I P J; Appel J Z; Awwad M; Sachs D H; Weir G; Squifflet J P; Cooper D K C; Morel Ph
Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade.
Xenotransplantation 2002;9(1):3-13.
2002: McMorrow Isabel M; Narayan Kavitha; Sachs David H; LeGuern Christian
New intra-renal graft genes associated with tolerance or rejection.
Kidney international 2002;61(1 Suppl):S85-93.
2002: Teranishi K; Gollackner B; Bühler L; Knosalla C; Correa L; Down J D; White-Scharf M E; Sachs D H; Awwad M; Cooper D K C
Depletion of anti-gal antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to gal oligosaccharides.
Transplantation 2002;73(1):129-39.
2002: Bühler L; Awwad M; Treter S; Chang Q; Basker M; Alwayn I P J; Teranishi K; Ericsson T; Moran K; Harper D; Kurilla-Mahon B; Huang C A; Sackstein R; Sykes M; White-Scharf M E; Sachs D H; Down J D; Cooper D K
Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade.
Transplantation 2002;73(1):12-22.
2002: Cooper David K C; Gollackner Bernd; Sachs David H
Will the pig solve the transplantation backlog?
Annual review of medicine 2002;53():133-47.
2001: Bühler L; Alwayn I P; Basker M; Oravec G; Thall A; White-Scharf M E; Sachs D H; Awwad M; Cooper D K
CD40-CD154 pathway blockade requires host macrophages to induce humoral unresponsiveness to pig hematopoietic cells in baboons.
Transplantation 2001;72(11):1759-68.
2001: Bühler L; Yamada K; Kitamura H; Alwayn I P; Basker M; Appel J Z; Colvin R B; White-Scharf M E; Sachs D H; Robson S C; Awwad M; Cooper D K
Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation.
Transplantation 2001;72(11):1743-52.
2001: Basker M; Alwayn I P; Buhler L; Harper D; Abraham S; Kruger Gray H; DeAngelis H; Awwad M; Down J; Rieben R; White-Scharf M E; Sachs D H; Thall A; Cooper D K
Clearance of mobilized porcine peripheral blood progenitor cells is delayed by depletion of the phagocytic reticuloendothelial system in baboons.
Transplantation 2001;72(7):1278-85.
2001: Rodriguez-Barbosa J I; Zhao Y; Barth R; Zhao G; Arn J S; Sachs D H; Sykes M
Enhanced CD4 reconstitution by grafting neonatal porcine tissue in alternative locations is associated with donor-specific tolerance and suppression of preexisting xenoreactive T cells.
Transplantation 2001;72(7):1223-31.
2001: Baron C; McMorrow I; Sachs D H; LeGuern C
Persistence of dominant T cell clones in accepted solid organ transplants.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4154-60.
2001: Gargollo P; Yamada K; Esnaola N; Fuchimoto Y; Newell K L; Sachs D H; Huang C A
Neuropathy in miniature swine after administration of the mutant diphtheria toxin-based immunotoxin, pCD3-CRM9.
Transplantation 2001;72(5):818-22.
2001: Kunisaki S M; Haller G W; Fuchimoto Y; Huang C A; Sachs D H
Peripheral regulation of graft-versus-host alloreactivity in mixed chimeric miniature swine.
Transplantation 2001;72(3):523-6.
2001: Alwayn I P; Xu Y; Basker M; Wu C; Buhler L; Lambrigts D; Treter S; Harper D; Kitamura H; Vitetta E S; Abraham S; Awwad M; White-Scharf M E; Sachs D H; Thall A; Cooper D K
Effects of specific anti-B and/or anti-plasma cell immunotherapy on antibody production in baboons: depletion of CD20- and CD22-positive B cells does not result in significantly decreased production of anti-alphaGal antibody.
Xenotransplantation 2001;8(3):157-71.
2001: Kawai T; Sogawa H; Koulmanda M; Smith R N; O'Neil J J; Wee S L; Boskovic S; Sykes M; Colvin R B; Sachs D H; Auchincloss H; Cosimi A B; C Ko D S
Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor.
Transplantation 2001;72(2):351-4.
2001: Fuchimoto Y; Gleit Z L; Huang C A; Kitamura H; Schwarze M L; Menard M T; Mawulawde K; Madsen J C; Sachs D H
Skin-specific alloantigens in miniature swine.
Transplantation 2001;72(1):122-6.
2001: Bühler L; Goepfert C; Kitamura H; Basker M; Gojo S; Alwayn I P; Chang Q; Down J D; Tsai H; Wise R; Sachs D H; Cooper D K; Robson S C; Sackstein R
Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy.
Bone marrow transplantation 2001;27(12):1227-36.
2001: Brander C; Matter-Reissmann U B; Jones N G; Walker B D; Sachs D H; Seebach J D
Inhibition of human NK cell-mediated cytotoxicity by exposure to ammonium chloride.
Journal of immunological methods 2001;252(1-2):1-14.
2001: Utsugi R; Barth R N; Lee R S; Kitamura H; LaMattina J C; Ambroz J; Sachs D H; Yamada K
Induction of transplantation tolerance with a short course of tacrolimus (FK506): I. Rapid and stable tolerance to two-haplotype fully mhc-mismatched kidney allografts in miniature swine.
Transplantation 2001;71(10):1368-79.
2001: Sykes M; Sachs D H
Mixed chimerism.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1409):707-26.
2001: Lee W P; Rubin J P; Bourget J L; Cober S R; Randolph M A; Nielsen G P; Ierino F L; Sachs D H
Tolerance to limb tissue allografts between swine matched for major histocompatibility complex antigens.
Plastic and reconstructive surgery 2001;107(6):1482-90; discussion 1491-2.
2001: Bourget J L; Mathes D W; Nielsen G P; Randolph M A; Tanabe Y N; Ferrara V R; Wu A; Arn S; Sachs D H; Lee W P
Tolerance to musculoskeletal allografts with transient lymphocyte chimerism in miniature swine.
Transplantation 2001;71(7):851-6.
2001: Huang C A; Fuchimoto Y; Gleit Z L; Ericsson T; Griesemer A; Scheier-Dolberg R; Melendy E; Kitamura H; Fishman J A; Ferry J A; Harris N L; Patience C; Sachs D H
Posttransplantation lymphoproliferative disease in miniature swine after allogeneic hematopoietic cell transplantation: similarity to human PTLD and association with a porcine gammaherpesvirus.
Blood 2001;97(5):1467-73.
2001: Wu A; Yamada K; Awwad M; Kitamura H; Wain J; Neville D M; Cooper D K; Sykes M; Sachs D H
Effects of xenogeneic thymic transplantation in baboons.
Transplantation proceedings 2001;33(1-2):766.
2001: Bühler L; Yamada K; Alwayn I; Kitamura H; Basker M; Barth R N; Appel J; Awwad M; Thall A; White-Scharf M E; Sachs D H; Cooper D K
Miniature swine and hDAF pig kidney transplantation in baboons treated with a nonmyeloablative regimen and CD154 blockade.
Transplantation proceedings 2001;33(1-2):716.
2001: Mathes D W; Bourget J L; Randolph M A; Solari M G; Wu A; Sachs D H; Lee W P
Tolerance to vascularized musculoskeletal allografts.
Transplantation proceedings 2001;33(1-2):616-7.
2001: Allan J S; Wain J C; Schwarze M L; Houser S L; Madsen J C; Sachs D H
Obliterative bronchiolitis develops in miniature swine transplanted across a minor histocompatibility barrier.
Transplantation proceedings 2001;33(1-2):358-9.
2001: Fuchimoto Y; Huang C A; Gleit Z L; Kitamura H; Griesemer A; Melendy E; Scheier-Dolberg R; White-Scharf M E; Sachs D H
Mixed chimerism using a nonmyelosuppressive regimen in miniature swine.
Transplantation proceedings 2001;33(1-2):118-9.
2001: Sogawa H; Kawai T; Wee S L; Boskovic S; Nadazdin O; Phelan J; Abrahamian G; Ko D S; Hong H; Mauiyyedi S; Colvin R B; Sachs D H; Cosimi A B
Comparison of horse antithymocyte globulin with other T cell-depleting antibodies for induction of chimerism and renal allograft tolerance in nonhuman primates.
Transplantation proceedings 2001;33(1-2):116-7.
2001: Utsugi R; Barth R N; Kitamura H; Ambroz J; Sachs D H; Yamada K
Tolerance across a two-haplotype, fully MHC-mismatched barrier induced in miniature swine renal allografts treated with a 12-day course of tacrolimus.
Transplantation proceedings 2001;33(1-2):101.
2001: Mathes D W; Yamada K; Randolph M A; Utsugi R; Solari M G; Gazelle G S; Wu A; Sachs D H; Lee W P
In utero induction of transplantation tolerance.
Transplantation proceedings 2001;33(1-2):98-100.
2001: Lee R S; Rusche J R; Maloney M E; Sachs D H; Sayegh M H; Madsen J C
CTLA4Ig-induced linked regulation of allogeneic T cell responses.
Transplantation proceedings 2001;33(1-2):88-9.
2001: Wu A; Ierino F L; Yamada K; Sachs D H
Specific suppression of proliferative responses by primed lymphocytes of tolerant miniature swine.
Transplantation proceedings 2001;33(1-2):87.
2001: Fuchimoto Y; Huang C A; Yamada K; Gleit Z L; Kitamura H; Griesemer A; Scheier-Dolberg R; Melendy E; White-Scharf M E; Sachs D H
Induction of kidney allograft tolerance through mixed chimerism in miniature swine.
Transplantation proceedings 2001;33(1-2):77.
2001: Seebach J D; Schneider M K; Comrack C A; LeGuern A; Kolb S A; Knolle P A; Germana S; DerSimonian H; LeGuern C; Sachs D H
Immortalized bone-marrow derived pig endothelial cells.
Xenotransplantation 2001;8(1):48-61.
2001: Rubin J P; Cober S R; Butler P E; Randolph M A; Gazelle G S; Ierino F L; Sachs D H; Lee W P
Injection of allogeneic bone marrow cells into the portal vein of swine in utero.
The Journal of surgical research 2001;95(2):188-94.
2001: Baron C; Sachs D H; LeGuern C
A particular TCR beta variable region used by T cells infiltrating kidney transplants.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2589-96.
2001: Lee R S; Rusche J R; Maloney M E; Sachs D H; Sayegh M H; Madsen J C
CTLA4Ig-induced linked regulation of allogeneic T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1572-82.
2001: Sonntag K C; Emery D W; Yasumoto A; Haller G; Germana S; Sablinski T; Shimizu A; Yamada K; Shimada H; Arn S; Sachs D H; LeGuern C
Tolerance to solid organ transplants through transfer of MHC class II genes.
The Journal of clinical investigation 2001;107(1):65-71.
2001: Dey B R; McAfee S; Sackstein R; Colby C; Saidman S; Weymouth D; Poliquin C; Vanderklish J; Sachs D H; Sykes M; Spitzer T R
Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2001;7(11):604-12.
2000: Shimizu A; Yamada K; Sachs D H; Colvin R B
Intragraft events preceding chronic renal allograft rejection in a modified tolerance protocol.
Kidney international 2000;58(6):2546-58.
2000: Shimizu A; Yamada K; Meehan S M; Sachs D H; Colvin R B
Acceptance reaction: intragraft events associated with tolerance to renal allografts in miniature swine.
Journal of the American Society of Nephrology : JASN 2000;11(12):2371-80.
2000: Bühler L; Basker M; Alwayn I P; Goepfert C; Kitamura H; Kawai T; Gojo S; Kozlowski T; Ierino F L; Awwad M; Sachs D H; Sackstein R; Robson S C; Cooper D K
Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates.
Transplantation 2000;70(9):1323-31.
2000: Bagley J; Wu Y; Sachs D H; Iacomini J
Defining the requirements for peptide recognition in gene therapy-induced T cell tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4842-7.
2000: Sonntag K C; Nebhard N; Haller G W; Yasumoto A; Sachs D H; LeGuern C
Assessment of transduction rates of porcine bone marrow.
Journal of hematotherapy & stem cell research 2000;9(5):721-6.
2000: Sonntag K C; Haller G W; Giauffret D; Germana S; Reeves S A; Levy J; Sachs D H; LeGuern C
Regulated expression of an MHC class II gene from a promoter-inducible retrovirus.
Human gene therapy 2000;11(14):1961-9.
2000: Watts A; Foley A; Awwad M; Treter S; Oravec G; Buhler L; Alwayn I P; Kozlowski T; Lambrigts D; Gojo S; Basker M; White-Scharf M E; Andrews D; Sachs D H; Cooper D K
Plasma perfusion by apheresis through a Gal immunoaffinity column successfully depletes anti-Gal antibody: experience with 320 aphereses in baboons.
Xenotransplantation 2000;7(3):181-5.
2000: Bühler L; Treter S; McMorrow I; Neethling F A; Alwayn I; Awwad M; Thall A; Cooper D K; LeGuern C; Sachs D H
Injection of porcine anti-idiotypic antibodies to primate anti-Gal antibodies leads to active inhibition of serum cytotoxicity in a baboon.
Transplantation proceedings 2000;32(5):1102.
2000: Bühler L; Awwad M; Treter S; Basker M; Ericson T; Lachance A; Oldmixon B; Kurilla-Mahon B; Gojo S; Huang C; Thall A; Down J D; White-Scharf M E; Sachs D H; Cooper D K
Induction of mixed hematopoietic chimerism in the pig-to-baboon model.
Transplantation proceedings 2000;32(5):1101.
2000: Bühler L; Awwad M; Basker M; Gojo S; Thall A; Down J D; Sykes M; Andrews D; Sackstein R; White-Scharf M E; Sachs D H; Cooper D K
A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons.
Transplantation proceedings 2000;32(5):1100.
2000: Alwayn I P; Buhler L; Basker M; Goepfert C; Kawai T; Kozlowski T; Ierino F; Sachs D H; Sackstein R; Robson S C; Cooper D K
Coagulation/thrombotic disorders associated with organ and cell xenotransplantation.
Transplantation proceedings 2000;32(5):1099.
2000: Wu A; Yamada K; Awwad M; Shimizu A; Watts A; Murphy M; Gojo S; Neville D; Cooper D K; Sykes M; Sachs D H
Experience with porcine thymic transplantation in baboons.
Transplantation proceedings 2000;32(5):1048.
2000: Abe M; Chen A M; Qi J; Sachs D H; Sykes M; Yang Y
Porcine stem cell factor facilitates long-lasting porcine hematopoietic engraftment in murine recipients.
Transplantation proceedings 2000;32(5):1047.
2000: Down J D; Awwad M; Kurilla-Mahon B; Moran K; Ericsson T; Oldmixon B; Lachance A; Watts A; Treter S; Nash K; Gojo S; Sachs D H; White-Scharf M E; Cooper D K
Increases in autologous hematopoietic progenitors in the blood of baboons following irradiation and treatment with porcine stem cell factor and interleukin-3.
Transplantation proceedings 2000;32(5):1045-6.
2000: Basker M; Alwayn I P; Treter S; Harper D; Buhler L; Andrews D; Thall A; Lambrigts D; Awwad M; White-Scharf M; Sachs D H; Cooper D K
Effect of B cell/plasma cell depletion or suppression on anti-Gal antibody in the baboon.
Transplantation proceedings 2000;32(5):1009.
2000: Watts A; Foley A; Awwad M; Treter S; Lambrigts D; Buhler L; Gojo S; Basker M; Oravec G; Sachs D H; Andrews D; Cooper D K
Plasma perfusion by apheresis through a gal immunoaffinity column successfully depletes anti-Gal antibody: experience with 275 aphereses in baboons.
Transplantation proceedings 2000;32(5):860.
2000: Salmon H; Johnson I; Germana S; Haller G W; Sachs D H; Leguern C
Dendritic cells enriched from swine thymus co-express CD1, CD2 and major histocompatibility complex class II and actively stimulate alloreactive T lymphocytes.
Scandinavian journal of immunology 2000;52(2):164-72.
2000: Kawai T; Wee S L; Bazin H; Latinne D; Phelan J; Boskovic S; Ko D S; Hong H Z; Mauiyyedi S; Nadazdin O; Abrahamian G; Preffer F; Colvin R B; Sachs D H; Cosimi A B
Association of natural killer cell depletion with induction of mixed chimerism and allograft tolerance in non-human primates.
Transplantation 2000;70(2):368-74.
2000: Schwarze M L; Menard M T; Fuchimoto Y; Huang C A; Houser S; Mawulawde K; Allison K S; Sachs D H; Madsen J C
Mixed hematopoietic chimerism induces long-term tolerance to cardiac allografts in miniature swine.
The Annals of thoracic surgery 2000;70(1):131-8; discussion 138-9.
2000: Chen A M; Zhou Y; Swenson K; Sachs D H; Sykes M; Yang Y G
Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers.
Transplantation 2000;69(12):2484-90.
2000: Shimizu A; Meehan S M; Kozlowski T; Sablinski T; Ierino F L; Cooper D K; Sachs D H; Colvin R B
Acute humoral xenograft rejection: destruction of the microvascular capillary endothelium in pig-to-nonhuman primate renal grafts.
Laboratory investigation; a journal of technical methods and pathology 2000;80(6):815-30.
2000: Bühler L; Awwad M; Basker M; Gojo S; Watts A; Treter S; Nash K; Oravec G; Chang Q; Thall A; Down J D; Sykes M; Andrews D; Sackstein R; White-Scharf M E; Sachs D H; Cooper D K
High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response.
Transplantation 2000;69(11):2296-304.
2000: Fuchimoto Y; Huang C A; Yamada K; Shimizu A; Kitamura H; Colvin R B; Ferrara V; Murphy M C; Sykes M; White-Scharf M; Neville D M; Sachs D H
Mixed chimerism and tolerance without whole body irradiation in a large animal model.
The Journal of clinical investigation 2000;105(12):1779-89.
2000: Zhao Y; Rodriguez-Barbosa J I; Swenson K; Barth R N; Shimizu A; Arn J S; Sachs D H; Sykes M
The induction of specific pig skin graft tolerance by grafting with neonatal pig thymus in thymectomized mice.
Transplantation 2000;69(7):1447-51.
2000: Yamada K; Mawulawde K; Menard M T; Shimizu A; Aretz H T; Choo J K; Allison K S; Slisz J K; Sachs D H; Madsen J C
Mechanisms of tolerance induction and prevention of cardiac allograft vasculopathy in miniature swine: the effect of augmentation of donor antigen load.
The Journal of thoracic and cardiovascular surgery 2000;119(4 Pt 1):709-19.
2000: Sachs D H
Mixed chimerism as an approach to transplantation tolerance.
Clinical immunology (Orlando, Fla.) 2000;95(1 Pt 2):S63-8.
2000: Gojo S; Shimizu A; Ierino F L; Banerjee P T; Cooper D K; LeGuern C; Sachs D H
Xenogeneic and allogeneic skin grafting after retrovirus-mediated SLA class II DR gene transfer in baboons.
Transplantation proceedings 2000;32(2):289-90.
2000: Lee R S; Yamada K; Womer K L; Pillsbury E P; Allison K S; Marolewski A E; Geng D; Thall A D; Arn J S; Sachs D H; Sayegh M H; Madsen J C
Blockade of CD28-B7, but not CD40-CD154, prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3434-44.
2000: Yamada K; Shimizu A; Utsugi R; Ierino F L; Gargollo P; Haller G W; Colvin R B; Sachs D H
Thymic transplantation in miniature swine. II. Induction of tolerance by transplantation of composite thymokidneys to thymectomized recipients.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3079-86.
2000: Yang Y G; Chen A M; Garrett L J; Sergio J J; Theodore P; Awwad M; VerHalen J; Bodine D M; Sachs D H; Sykes M
Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier.
Xenotransplantation 2000;7(1):58-64.
2000: Warrens A N; Simon A R; Theodore P R; Sachs D H; Sykes M
Cross-species compatibility of intercellular adhesion molecule-1 (CD54) with its ligands.
Transplantation 2000;69(3):394-9.
2000: Kozlowski T; Sablinski T; Basker M; Kitamura H; Spitzer T R; Fishman J; Sykes M; Cooper D K; Sachs D H
Decreased graft-versus-host disease after haplotype mismatched bone marrow allografts in miniature swine following interleukin-2 treatment.
Bone marrow transplantation 2000;25(1):47-52.
2000: Colby C; Chang Q; Fuchimoto Y; Ferrara V; Murphy M; Sackstein R; Spitzer T R; White-Scharf M E; Sachs D H
Cytokine-mobilized peripheral blood progenitor cells for allogeneic reconstitution of miniature swine.
Transplantation 2000;69(1):135-40.
2000: Huang C A; Fuchimoto Y; Scheier-Dolberg R; Murphy M C; Neville D M; Sachs D H
Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model.
The Journal of clinical investigation 2000;105(2):173-81.
2000: Spitzer T R; McAfee S; Sackstein R; Colby C; Toh H C; Multani P; Saidman S; Weyouth D W; Preffer F; Poliquin C; Foley A; Cox B; Andrews D; Sachs D H; Sykes M
Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2000;6(3A):309-20.
1999: Nash K; Chang Q; Watts A; Treter S; Oravec G; Ferrara V; Buhler L; Basker M; Gojo S; Sachs D H; White-Scharf M; Down J D; Cooper D K
Peripheral blood progenitor cell mobilization and leukapheresis in pigs.
Laboratory animal science 1999;49(6):645-9.
1999: Kawai T; Poncelet A; Sachs D H; Mauiyyedi S; Boskovic S; Wee S L; Ko D S; Bartholomew A; Kimikawa M; Hong H Z; Abrahamian G; Colvin R B; Cosimi A B
Long-term outcome and alloantibody production in a non-myeloablative regimen for induction of renal allograft tolerance.
Transplantation 1999;68(11):1767-75.
1999: Bartholomew A M; Powelson J; Sachs D H; Bailin M; Boskovic S; Colvin R; Hong H Z; Johnson M; Kimikawa M; LeGuern A; Meehan S; Sablinski T; Wee S L; Cosimi A B
Tolerance in a concordant nonhuman primate model.
Transplantation 1999;68(11):1708-16.
1999: Yamada K; Shimizu A; Ierino F L; Utsugi R; Barth R N; Esnaola N; Colvin R B; Sachs D H
Thymic transplantation in miniature swine. I. Development and function of the "thymokidney".
Transplantation 1999;68(11):1684-92.
1999: Kawai T; Sachs D H; Cosimi A B
Tolerance to vascularized organ allografts in large-animal models.
Current opinion in immunology 1999;11(5):516-20.
1999: Haller G W; Esnaola N; Yamada K; Wu A; Shimizu A; Hansen A; Ferrara V R; Allison K S; Colvin R B; Sykes M; Sachs D H
Thymic transplantation across an MHC class I barrier in swine.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(7):3785-92.
1999: Shimada H; Germana S; Sonntag K C; Banerjee P; Moore D; Sachs D H; LeGuern C
MHC class II alpha/beta heterodimeric cell surface molecules expressed from a single proviral genome.
Human gene therapy 1999;10(14):2397-405.
1999: Huang C A; Yamada K; Murphy M C; Shimizu A; Colvin R B; Neville D M; Sachs D H
In vivo T cell depletion in miniature swine using the swine CD3 immunotoxin, pCD3-CRM9.
Transplantation 1999;68(6):855-60.
1999: Huang C A; Lorf T; Arn J S; Koo G C; Blake T; Sachs D H
Characterization of a monoclonal anti-porcine CD3 antibody.
Xenotransplantation 1999;6(3):201-12.
1999: Yamada K; Choo J K; Allan J S; Erhorn A E; Menard M T; Mawulawde K; Slisz J K; Aretz H T; Shimizu A; Sachs D H; Madsen J C
The effect of thymectomy on tolerance induction and cardiac allograft vasculopathy in a miniature swine heart/kidney transplantation model.
Transplantation 1999;68(4):485-91.
1999: Spitzer T R; Delmonico F; Tolkoff-Rubin N; McAfee S; Sackstein R; Saidman S; Colby C; Sykes M; Sachs D H; Cosimi A B
Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism.
Transplantation 1999;68(4):480-4.
1999: Emery D W; Holley K; Sachs D H
Enhancement of swine progenitor chimerism in mixed swine/human bone marrow cultures with swine cytokines.
Experimental hematology 1999;27(8):1330-7.
1999: Fuchimoto Y; Huang C; Shimizu A; Seebach J; Arn S; Sachs D H
An allelic non-histocompatibility antigen with wide tissue distribution as a marker for chimerism in pigs.
Tissue antigens 1999;54(1):43-52.
1999: Seebach J D; Pazmany L; Waneck G L; Minja F; Germana S; LeGuern C; Sachs D H
HLA-G expression on porcine endothelial cells protects partially against direct human NK cytotoxicity but not against ADCC.
Transplantation proceedings 1999;31(4):1864-5.
1999: Fuchimoto Y; Yamada K; Shimizu A; Yasumoto A; Sawada T; Huang C H; Sachs D H
Relationship between chimerism and tolerance in a kidney transplantation model.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5704-11.
1999: Friedman T; Shimizu A; Smith R N; Colvin R B; Seebach J D; Sachs D H; Iacomini J
Human CD4+ T cells mediate rejection of porcine xenografts.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5256-62.
1999: Ierino F L; Gojo S; Banerjee P T; Giovino M; Xu Y; Gere J; Kaynor C; Awwad M; Monroy R; Rembert J; Hatch T; Foley A; Kozlowski T; Yamada K; Neethling F A; Fishman J; Bailin M; Spitzer T R; Cooper D K; Cosimi A B; LeGuern C; Sachs D H
Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers.
Transplantation 1999;67(8):1119-28.
1999: Yamada K; Ierino F L; Gianello P R; Shimizu A; Colvin R B; Sachs D H
Role of the thymus in transplantation tolerance in miniature swine. III. Surgical manipulation of the thymus interferes with stable induction of tolerance to class I-mismatched renal allografts.
Transplantation 1999;67(8):1112-9.
1999: Sablinski T; Emery D W; Monroy R; Hawley R J; Xu Y; Gianello P; Lorf T; Kozlowski T; Bailin M; Cooper D K; Cosimi A B; Sachs D H
Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors.
Transplantation 1999;67(7):972-7.
1999: Sachs D H
Immunologic tolerance to organ transplants.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 1999;3(2):105-10.
1999: Nikolic B; Gardner J P; Scadden D T; Arn J S; Sachs D H; Sykes M
Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3402-7.
1999: Chae S J; Kramer A D; Zhao Y; Arn S; Cooper D K; Sachs D H
Lack of variation in alphaGal expression on lymphocytes in miniature swine of different genotypes.
Xenotransplantation 1999;6(1):43-51.
1999: Kozlowski T; Monroy R; Giovino M; Hawley R J; Glaser R; Li Z; Meshulam D H; Spitzer T R; Cooper D K; Sachs D H
Effect of pig-specific cytokines on mobilization of hematopoietic progenitor cells in pigs and on pig bone marrow engraftment in baboons.
Xenotransplantation 1999;6(1):17-27.
1999: Yamada K; Shimizu A; Ierino F L; Gargollo P; Barth R; Colvin R B; Sachs D H
Allogeneic thymo-kidney transplants induce stable tolerance in miniature swine.
Transplantation proceedings 1999;31(1-2):1199-200.
1999: Wu A; Esnaola N F; Yamada K; Awwad M; Shimizu A; Huang C; Wain J; Zhao Y; Neville D M; Cooper D K; Sykes M; Sachs D H
Xenogeneic thymic transplantation in a pig-to-nonhuman primate model.
Transplantation proceedings 1999;31(1-2):957.
1999: Yamada K; Menard M T; Mawulawde K; Slisz J K; Choo J K; Erhorn A E; Sachs D H; Madsen J C
The effects of heart/kidney versus double heart transplantation on tolerance induction and prevention of cardiac allograft vasculopathy.
Transplantation proceedings 1999;31(1-2):108.
1999: Yamada K; Gianello P R; Ierino F L; Fishbein J; Lorf T; Shimizu A; Colvin R B; Sachs D H
Role of the thymus in transplantation tolerance in miniature swine: II. Effect of steroids and age on the induction of tolerance to class I mismatched renal allografts.
Transplantation 1999;67(3):458-67.
1999: Kozlowski T; Shimizu A; Lambrigts D; Yamada K; Fuchimoto Y; Glaser R; Monroy R; Xu Y; Awwad M; Colvin R B; Cosimi A B; Robson S C; Fishman J; Spitzer T R; Cooper D K; Sachs D H
Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption.
Transplantation 1999;67(1):18-30.
1999: Ierino F L; Yamada K; Hatch T; Rembert J; Sachs D H
Peripheral tolerance to class I mismatched renal allografts in miniature swine: donor antigen-activated peripheral blood lymphocytes from tolerant swine inhibit antidonor CTL reactivity.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):550-9.
1999: Shimada H; Alexander R C; Germana S; Sachs D H; LeGuern C
Recombinant retrovirus vectors for the expression of MHC class II heterodimers.
Surgery today 1999;29(6):533-41.
1998: Sachs D H
The immunology of xenotransplantation: introduction.
Annals of the New York Academy of Sciences 1998;862():1-4.
1998: Ierino F L; Kozlowski T; Siegel J B; Shimizu A; Colvin R B; Banerjee P T; Cooper D K; Cosimi A B; Bach F H; Sachs D H; Robson S C
Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts.
Transplantation 1998;66(11):1439-50.
1998: Allan J S; Slisz J K; Vesga L; Arn J S; Yamada K; Sachs D H; Madsen J C
Enhanced efficacy of repeated anti-CD8 monoclonal antibody therapy by high-dose cyclosporine treatment.
Transplantation proceedings 1998;30(8):4062-3.
1998: Ko D S; Bartholomew A; Poncelet A J; Sachs D H; Huang C; LeGuern A; Abraham K I; Colvin R B; Boskovic S; Hong H Z; Wee S L; Winn H J; Cosimi A B
Demonstration of multilineage chimerism in a nonhuman primate concordant xenograft model.
Xenotransplantation 1998;5(4):298-304.
1998: Lambrigts D; Van Calster P; Xu Y; Awwad M; Neethling F A; Kozlowski T; Foley A; Watts A; Chae S J; Fishman J; Thall A D; White-Scharf M E; Sachs D H; Cooper D K
Pharmacologic immunosuppressive therapy and extracorporeal immunoadsorption in the suppression of anti-alphaGal antibody in the baboon.
Xenotransplantation 1998;5(4):274-83.
1998: Emery D W; Shimada H; Germana S; Sachs D H; LeGuern C
Transfer of porcine MHC DRalpha into IEalpha-deficient murine bone marrow results in reduced IE-restricted Vbeta usage.
Transplantation 1998;66(8):1081-8.
1998: Lambrigts D; Menard M T; Alexandre G P; Franssen C; Meurisse M; Van Calster P; Coignoul F; Mawulawde K; Choo J K; Yamada K; Erhorn A E; Slisz J K; Chiotellis P; Aretz H T; Sachs D H; Madsen J C
Creation of the "thymoheart" allograft: implantation of autologous thymus into the heart prior to procurement.
Transplantation 1998;66(6):810-4.
1998: Lambrigts D; Sachs D H; Cooper D K
Discordant organ xenotransplantation in primates: world experience and current status.
Transplantation 1998;66(5):547-61.
1998: Lee W P; Rubin J P; Cober S; Ierino F; Randolph M A; Sachs D H
Use of swine model in transplantation of vascularized skeletal tissue allografts.
Transplantation proceedings 1998;30(6):2743-5.
1998: Ierino F L; Yamada K; Lorf T; Arn J S; Sachs D H
Mechanism of tolerance to class I-mismatched renal allografts in miniature swine: regulation of interleukin-2 receptor alpha-chain expression on CD8 peripheral blood lymphocytes of tolerant animals.
Transplantation 1998;66(4):454-60.
1998: Sachs D H
Transplantation tolerance.
Transplantation proceedings 1998;30(5):1627-9.
1998: Simon A R; Warrens A N; Yazzie N P; Seebach J D; Sachs D H; Sykes M
Cross-species interaction of porcine and human integrins with their respective ligands: implications for xenogeneic tolerance induction.
Transplantation 1998;66(3):385-94.
1998: Warrens A N; Simon A R; Theodore P R; Sachs D H; Sykes M
Function of porcine adhesion molecules in a human marrow microenvironment.
Transplantation 1998;66(2):252-9.
1998: Kozlowski T; Monroy R; Xu Y; Glaser R; Awwad M; Cooper D K; Sachs D H
Anti-Gal(alpha)1-3Gal antibody response to porcine bone marrow in unmodified baboons and baboons conditioned for tolerance induction.
Transplantation 1998;66(2):176-82.
1998: Kozlowski T; Ierino F L; Lambrigts D; Foley A; Andrews D; Awwad M; Monroy R; Cosimi A B; Cooper D K; Sachs D H
Depletion of anti-Gal(alpha)1-3Gal antibody in baboons by specific alpha-Gal immunoaffinity columns.
Xenotransplantation 1998;5(2):122-31.
1998: Sachs D H
Brushing up on immunological tolerance. Immunologic Tolerance for Immune System Mediated Diseases, Bethesda, MD, USA, 8 December 1997.
Molecular medicine today 1998;4(3):105-6.
1998: Madsen J C; Yamada K; Allan J S; Choo J K; Erhorn A E; Pins M R; Vesga L; Slisz J K; Sachs D H
Transplantation tolerance prevents cardiac allograft vasculopathy in major histocompatibility complex class I-disparate miniature swine.
Transplantation 1998;65(3):304-13.
1998: Xu Y; Lorf T; Sablinski T; Gianello P; Bailin M; Monroy R; Kozlowski T; Awwad M; Cooper D K; Sachs D H
Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column.
Transplantation 1998;65(2):172-9.
1998: Auchincloss H; Sachs D H
Xenogeneic transplantation.
Annual review of immunology 1998;16():433-70.
1997: Colby C; Sykes M; Sachs D H; Spitzer T R
Cellular modulation of acute graft-vs.-host disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1997;3(6):287-93.
1997: Emery D W; Sablinski T; Shimada H; Germana S; Gianello P; Foley A; Shulman S; Arn S; Fishman J; Lorf T; Nickeleit V; Colvin R B; Sachs D H; LeGuern C
Expression of an allogeneic MHC DRB transgene, through retroviral transduction of bone marrow, induces specific reduction of alloreactivity.
Transplantation 1997;64(10):1414-23.
1997: Choo J K; Seebach J D; Nickeleit V; Shimizu A; Lei H; Sachs D H; Madsen J C
Species differences in the expression of major histocompatibility complex class II antigens on coronary artery endothelium: implications for cell-mediated xenoreactivity.
Transplantation 1997;64(9):1315-22.
1997: Allan J S; Choo J K; Vesga L; Arn J S; Pins M R; Sachs D H; Madsen J C
Cardiac allograft vasculopathy is abrogated by anti-CD8 monoclonal antibody therapy.
The Annals of thoracic surgery 1997;64(4):1019-25.
1997: Seebach J D; Comrack C; Germana S; LeGuern C; Sachs D H; DerSimonian H
HLA-Cw3 expression on porcine endothelial cells protects against xenogeneic cytotoxicity mediated by a subset of human NK cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3655-61.
1997: Kimikawa M; Sachs D H; Colvin R B; Bartholomew A; Kawai T; Cosimi A B
Modifications of the conditioning regimen for achieving mixed chimerism and donor-specific tolerance in cynomolgus monkeys.
Transplantation 1997;64(5):709-16.
1997: Sullivan J A; Oettinger H F; Sachs D H; Edge A S
Analysis of polymorphism in porcine MHC class I genes: alterations in signals recognized by human cytotoxic lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2318-26.
1997: Zhao Y; Sergio J J; Swenson K; Arn J S; Sachs D H; Sykes M
Positive and negative selection of functional mouse CD4 cells by porcine MHC in pig thymus grafts.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2100-7.
1997: McMorrow I M; Comrack C A; Nazarey P P; Sachs D H; DerSimonian H
Relationship between ABO blood group and levels of Gal alpha,3Galactose-reactive human immunoglobulin G.
Transplantation 1997;64(3):546-9.
1997: McMorrow I M; Comrack C A; Sachs D H; DerSimonian H
Heterogeneity of human anti-pig natural antibodies cross-reactive with the Gal(alpha1,3)Galactose epitope.
Transplantation 1997;64(3):501-10.
1997: Yamada K; Gianello P R; Ierino F L; Lorf T; Shimizu A; Meehan S; Colvin R B; Sachs D H
Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts.
The Journal of experimental medicine 1997;186(4):497-506.
1997: Sawada T; Wu Y; Sachs D H; Iacomini J
CD4+ T cells are able to reject class I disparate allografts.
Transplantation 1997;64(2):335-40.
1997: Mayfield R S; Hayashi H; Sawada T; Bergen K; LeGuern C; Sykes M; Sachs D H; Iacomini J
The mechanism of specific prolongation of class I-mismatched skin grafts induced by retroviral gene therapy.
European journal of immunology 1997;27(5):1177-81.
1997: Sawada T; DellaPelle P A; Seebach J D; Sachs D H; Colvin R B; Iacomini J
Human cell-mediated rejection of porcine xenografts in an immunodeficient mouse model.
Transplantation 1997;63(9):1331-8.
1997: Sablinski T; Gianello P R; Bailin M; Bergen K S; Emery D W; Fishman J A; Foley A; Hatch T; Hawley R J; Kozlowski T; Lorf T; Meehan S; Monroy R; Powelson J A; Colvin R B; Cosimi A B; Sachs D H
Pig to monkey bone marrow and kidney xenotransplantation.
Surgery 1997;121(4):381-91.
1997: Giangrande I; Yamada K; Arn S; Lorf T; Sachs D H; LeGuern C
Selective increase in CD4-positive graft-infiltrating mononuclear cells among the infiltrates in class I disparate kidney grafts undergoing rejection.
Transplantation 1997;63(5):722-8.
1997: Kozlowski T; Fuchimoto Y; Monroy R; Bailin M; Martinez-Ruiz R; Foley A; Xu Y; Awwad M; Fishman J; Andrews D; Ritzenthaler J; Sablinski T; Ierino F L; Sachs D H
Apheresis and column absorption for specific removal of Gal-alpha-1,3 Gal natural antibodies in a pig-to-baboon model.
Transplantation proceedings 1997;29(1-2):961.
1997: Bartholomew A M; Cosimi A B; Sachs D H; Bailin M; Boskovic S; Colvin R; Hong H; Johnson M; Kimikawa M; Leguern A; Meehan S; Sablinski T; Wee S L; Powelson J
A study of tolerance in a concordant xenograft model.
Transplantation proceedings 1997;29(1-2):923-4.
1997: Zhao Y; Sergio J J; Pearson D A; Szot G L; Arn J S; Sachs D H; Sykes M
Repopulation of mouse CD4 cells in BALB/c nude mice receiving fetal pig thymus/liver grafts.
Transplantation proceedings 1997;29(1-2):1228-9.
1997: Kimikawa M; Kawai T; Sachs D H; Colvin R B; Bartholomew A; Cosimi A B
Mixed chimerism and transplantation tolerance induced by a nonlethal preparative regimen in cynomolgus monkeys.
Transplantation proceedings 1997;29(1-2):1218.
1997: Ierino F L; Yamada K; Hatch T; Sachs D H
Preliminary in vitro evidence for regulatory cells in a miniature swine renal allograft model.
Transplantation proceedings 1997;29(1-2):1165.
1997: Shimizu A; Yamada K; Meehan S M; Sachs D H; Colvin R B
Intragraft cellular events associated with tolerance in pig allografts: the "acceptance reaction".
Transplantation proceedings 1997;29(1-2):1155.
1997: Hayashi H; Mayfield R S; Sawada T; Germana S; Sykes M; Iacomini J; Sachs D H; LeGuern C
Role of the thymus in donor specific hyporesponsiveness induced by retroviral transduction of bone marrow using an MHC class I gene.
Transplantation proceedings 1997;29(1-2):1133.
1997: Yasumoto A; Yamada K; Sablinski T; LeGuern C; Sykes M; Sachs D H
Mechanism of tolerance following class II gene transduction of autologous swine bone marrow.
Transplantation proceedings 1997;29(1-2):1132.
1997: Germana S; Shimada H; Sachs D H; LeGuern C
Retroviral vectors transfer functional MHC class II heterodimers into bone marrow: a genetic approach to tolerance induction.
Transplantation proceedings 1997;29(1-2):1129.
1997: Yamada K; Gianello P R; Ierino F L; Shimizu A; Meehan S; Colvin R B; Sachs D H
Influence of the thymus on transplantation tolerance in miniature swine.
Transplantation proceedings 1997;29(1-2):1076.
1997: Zhao Y; Fishman J A; Sergio J J; Oliveros J L; Pearson D A; Szot G L; Wilkinson R A; Arn J S; Sachs D H; Sykes M
Immune restoration by fetal pig thymus grafts in T cell-depleted, thymectomized mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1641-9.
1997: Khan A; Sergio J J; Zhao Y; Pearson D A; Sachs D H; Sykes M
Discordant xenogeneic neonatal thymic transplantation can induce donor-specific tolerance.
Transplantation 1997;63(1):124-31.
1997: Blancho G; Gianello P R; Lorf T; Germana S; Giangrande I; Mourad G; Colvin R B; Sachs D H; LeGuern C
Molecular and cellular events implicated in local tolerance to kidney allografts in miniature swine.
Transplantation 1997;63(1):26-33.

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