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George Sachs

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Yi Wen; Jing Feng; George Sachs
Helicobacter pylori 5'ureB-sRNA, a cis-encoded antisense small RNA, negatively regulates ureAB expression by transcription termination.
David Strugatsky; Chiung-Kuang Chen; Reginald McNulty; Keith Munson; George Sachs; S Michael Soltis; Hartmut Luecke
Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori.
Elmira Tokhtaeva; Rebecca J Clifford; Jack H Kaplan; George Sachs; Olga Vagin
Subunit isoform selectivity in assembly of Na,K-ATPase α-β heterodimers.

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All Publications

2013: Yi Wen; Jing Feng; George Sachs
Helicobacter pylori 5'ureB-sRNA, a cis-encoded antisense small RNA, negatively regulates ureAB expression by transcription termination.
Journal of bacteriology 2013;195(3):444-52.
2013: David Strugatsky; Chiung-Kuang Chen; Reginald McNulty; Keith Munson; George Sachs; S Michael Soltis; Hartmut Luecke
Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori.
Nature 2013;493(7431):255-8.
2012: Elmira Tokhtaeva; Rebecca J Clifford; Jack H Kaplan; George Sachs; Olga Vagin
Subunit isoform selectivity in assembly of Na,K-ATPase α-β heterodimers.
The Journal of biological chemistry 2012;287(31):26115-25.
2012: Elmira Tokhtaeva; Laura A Dada; George Sachs; Haiying Sun; Jacob I Sznajder; Olga Vagin
Identification of the amino acid region involved in the intercellular interaction between the β1 subunits of Na+/K+ -ATPase.
Journal of cell science 2012;125(Pt 6):1605-16.
2011: George Sachs; Elizabeth A Marcus; David R Scott
The role of the NMDA receptor in Helicobacter pylori-induced gastric damage.
Gastroenterology 2011;141(6):1967-9.
2011: George Sachs; David R Scott; Yi Wen
Gastric infection by Helicobacter pylori.
Current gastroenterology reports 2011;13(6):540-6.
2011: Jai Moo Shin; David Strugatsky; Elmira Tokhtaeva; Olga Vagin; Nobuhiro Inatomi; Keith Munson; George Sachs
Characterization of a novel potassium-competitive acid blocker of the gastric H,K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438).
The Journal of pharmacology and experimental therapeutics 2011;339(2):412-20.
2011: Elmira Tokhtaeva; Julian P Whitelegge; Sara Bassilian; George Sachs; Liora Shoshani; Puneet Souda; Olga Vagin
Epithelial junctions depend on intercellular trans-interactions between the Na,K-ATPase β₁ subunits.
The Journal of biological chemistry 2011;286(29):25801-12.
2011: Yi Wen; Jing Feng; David R Scott; Elizabeth A Marcus; George Sachs
A cis-encoded antisense small RNA regulated by the HP0165-HP0166 two-component system controls expression of ureB in Helicobacter pylori.
Journal of bacteriology 2011;193(1):40-51.
2010: Elmira Tokhtaeva; George Sachs; Olga Vagin
Diverse pathways for maturation of the Na,K-ATPase β1 and β2 subunits in the endoplasmic reticulum of Madin-Darby canine kidney cells.
The Journal of biological chemistry 2010;285(50):39289-302.
2010: George Sachs; Jai Shin; Richard Hunt
Novel approaches to inhibition of gastric acid secretion.
Current gastroenterology reports 2010;12(6):437-47.
2010: Elmira Tokhtaeva; Keith Munson; George Sachs; Olga Vagin
N-glycan-dependent quality control of the Na,K-ATPase beta(2) subunit.
Biochemistry 2010;49(14):3116-28.
2010: David R Scott; Elizabeth A Marcus; Yi Wen; Siddarth Singh; Jing Feng; George Sachs
Cytoplasmic histidine kinase (HP0244)-regulated assembly of urease with UreI, a channel for urea and its metabolites, CO2, NH3, and NH4(+), is necessary for acid survival of Helicobacter pylori.
Journal of bacteriology 2010;192(1):94-103.
2009: Elmira Tokhtaeva; George Sachs; Olga Vagin
Assembly with the Na,K-ATPase alpha(1) subunit is required for export of beta(1) and beta(2) subunits from the endoplasmic reticulum.
Biochemistry 2009;48(48):11421-31.
2009: George Sachs; Yi Wen; David R Scott
Gastric infection by Helicobacter pylori.
Current gastroenterology reports 2009;11(6):455-61.
2009: Jai Shin; George Sachs; Young-moon Cho; Michael Garst
1-Arylsulfonyl-2-(pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs.
Molecules (Basel, Switzerland) 2009;14(12):5247-80.
2009: Yi Wen; Jing Feng; David R Scott; Elizabeth A Marcus; George Sachs
The pH-responsive regulon of HP0244 (FlgS), the cytoplasmic histidine kinase of Helicobacter pylori.
Journal of bacteriology 2009;191(2):449-60.
2009: Andreas Stengel; Miriam Goebel; Iskandar Yakubov; Lixin Wang; Derrick Witcher; Tamer Coskun; Yvette Taché; George Sachs; Nils W G Lambrecht
Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa.
Endocrinology 2009;150(1):232-8.
2009: Jai Shin; Keith Munson; Olga Vagin; George Sachs
The gastric HK-ATPase: structure, function, and inhibition.
Pflügers Archiv : European journal of physiology 2009;457(3):609-22.
2008: Jai Shin; George Sachs
Pharmacology of proton pump inhibitors.
Current gastroenterology reports 2008;10(6):528-34.
2008: Jai Shin; George Sachs; Jeffrey A Kraut
Simple diagnostic tests to detect toxic alcohol intoxications.
Translational research : the journal of laboratory and clinical medicine 2008;152(4):194-201.
2008: Olga Vagin; Elmira Tokhtaeva; Iskandar Yakubov; Eugenia Shevchenko; George Sachs
Inverse correlation between the extent of N-glycan branching and intercellular adhesion in epithelia. Contribution of the Na,K-ATPase beta1 subunit.
The Journal of biological chemistry 2008;283(4):2192-202.
2008: Jai Shin; Olga Vagin; Keith Munson; Mark Kidd; I M Modlin; George Sachs
Molecular mechanisms in therapy of acid-related diseases.
Cellular and molecular life sciences : CMLS 2008;65(2):264-81.
2007: Olga Vagin; George Sachs; Elmira Tokhtaeva
The roles of the Na,K-ATPase beta 1 subunit in pump sorting and epithelial integrity.
Journal of bioenergetics and biomembranes 2007;39(5-6):367-72.
2007: Cindy Zer; George Sachs; Jai Shin
Identification of genomic targets downstream of p38 mitogen-activated protein kinase pathway mediating tumor necrosis factor-alpha signaling.
Physiological genomics 2007;31(2):343-51.
2007: Nils W G Lambrecht; Iskandar Yakubov; George Sachs
Fasting-induced changes in ECL cell gene expression.
Physiological genomics 2007;31(2):183-92.
2007: George Sachs; Jai Shin; Olga Vagin; Nils W G Lambrecht; Iskandar Yakubov; Keith Munson
The gastric H,K ATPase as a drug target: past, present, and future.
Journal of clinical gastroenterology 2007;41 Suppl 2():S226-42.
2007: Keith Munson; Richard J Law; George Sachs
Analysis of the gastric H,K ATPase for ion pathways and inhibitor binding sites.
Biochemistry 2007;46(18):5398-417.
2007: David R Scott; Elizabeth A Marcus; Yi Wen; Jane Oh; George Sachs
Gene expression in vivo shows that Helicobacter pylori colonizes an acidic niche on the gastric surface.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(17):7235-40.
2007: Yi Wen; Jing Feng; David R Scott; Elizabeth A Marcus; George Sachs
The HP0165-HP0166 two-component system (ArsRS) regulates acid-induced expression of HP1186 alpha-carbonic anhydrase in Helicobacter pylori by activating the pH-dependent promoter.
Journal of bacteriology 2007;189(6):2426-34.
2006: Olga Vagin; Elmira Tokhtaeva; George Sachs
The role of the beta1 subunit of the Na,K-ATPase and its glycosylation in cell-cell adhesion.
The Journal of biological chemistry 2006;281(51):39573-87.
2006: George Sachs; Jai Shin; Colin Howden
Review article: the clinical pharmacology of proton pump inhibitors.
Alimentary pharmacology & therapeutics 2006;23 Suppl 2():2-8.
2006: Jai Shin; George Sachs
Gastric H,K-ATPase as a drug target.
Digestive diseases and sciences 2006;51(5):823-33.
2006: Jai Shin; Michel Homerin; Florence Domagala; Hervé Ficheux; George Sachs
Characterization of the inhibitory activity of tenatoprazole on the gastric H+,K+ -ATPase in vitro and in vivo.
Biochemical pharmacology 2006;71(6):837-49.
2006: Nils W G Lambrecht; Iskandar Yakubov; Cindy Zer; George Sachs
Transcriptomes of purified gastric ECL and parietal cells: identification of a novel pathway regulating acid secretion.
Physiological genomics 2006;25(1):153-65.
2006: Yi Wen; Jing Feng; David R Scott; Elizabeth A Marcus; George Sachs
Involvement of the HP0165-HP0166 two-component system in expression of some acidic-pH-upregulated genes of Helicobacter pylori.
Journal of bacteriology 2006;188(5):1750-61.
2006: George Sachs; Jeffrey A Kraut; Y Wen; J Feng; D R Scott
Urea transport in bacteria: acid acclimation by gastric Helicobacter spp.
The Journal of membrane biology 2006;212(2):71-82.
2005: Olga Vagin; Shahlo Turdikulova; George Sachs
Recombinant addition of N-glycosylation sites to the basolateral Na,K-ATPase beta1 subunit results in its clustering in caveolae and apical sorting in HGT-1 cells.
The Journal of biological chemistry 2005;280(52):43159-67.
2005: Jai Shin; Gerhard Grundler; Jörg Senn-Bilfinger; Wolfgang Alexander Simon; George Sachs
Functional consequences of the oligomeric form of the membrane-bound gastric H,K-ATPase.
Biochemistry 2005;44(49):16321-32.
2005: George Sachs; David L Weeks; Yi Wen; Elizabeth A Marcus; David R Scott; Klaus Melchers
Acid acclimation by Helicobacter pylori.
Physiology (Bethesda, Md.) 2005;20():429-38.
2005: Olga Mareninova; Jai Shin; Olga Vagin; Shahlo Turdikulova; Stefan Hallen; George Sachs
Topography of the membrane domain of the liver Na+-dependent bile acid transporter.
Biochemistry 2005;44(42):13702-12.
2005: Olga Vagin; Shahlo Turdikulova; Iskandar Yakubov; George Sachs
Use of the H,K-ATPase beta subunit to identify multiple sorting pathways for plasma membrane delivery in polarized cells.
The Journal of biological chemistry 2005;280(15):14741-54.
2005: Nils W G Lambrecht; Iskandar Yakubov; David Scott; George Sachs
Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion.
Physiological genomics 2005;21(1):81-91.
2005: Jeffrey A Kraut; George Sachs
Hartnup disorder: unraveling the mystery.
Trends in pharmacological sciences 2005;26(2):53-5.
2005: David S Oh; Sandy N Lieu; Dean J Yamaguchi; Ken Tachiki; Nils W G Lambrecht; Gordon V Ohning; George Sachs; Patrizia M Germano; Joseph R Pisegna
PACAP regulation of secretion and proliferation of pure populations of gastric ECL cells.
Journal of molecular neuroscience : MN 2005;26(1):85-97.
2005: Elizabeth A Marcus; Amiel P Moshfegh; George Sachs; David R Scott
The periplasmic alpha-carbonic anhydrase activity of Helicobacter pylori is essential for acid acclimation.
Journal of bacteriology 2005;187(2):729-38.
2004: Jai Shin; George Sachs
Differences in binding properties of two proton pump inhibitors on the gastric H+,K+-ATPase in vivo.
Biochemical pharmacology 2004;68(11):2117-27.
2004: Olga Vagin; Shahlo Turdikulova; George Sachs
The H,K-ATPase beta subunit as a model to study the role of N-glycosylation in membrane trafficking and apical sorting.
The Journal of biological chemistry 2004;279(37):39026-34.
2004: Jai Shin; Young Moon Cho; George Sachs
Chemistry of covalent inhibition of the gastric (H+, K+)-ATPase by proton pump inhibitors.
Journal of the American Chemical Society 2004;126(25):7800-11.
2004: Nayoung Kim; Elizabeth A Marcus; Yi Wen; David L Weeks; David R Scott; Hyun Chae Jung; In Sung Song; George Sachs
Genes of Helicobacter pylori regulated by attachment to AGS cells.
Infection and immunity 2004;72(4):2358-68.
2004: David L Weeks; Gene Gushansky; David R Scott; George Sachs
Mechanism of proton gating of a urea channel.
The Journal of biological chemistry 2004;279(11):9944-50.
2004: George Sachs; Jai Shin
The basis of differentiation of PPIs.
Drugs of today (Barcelona, Spain : 1998) 2004;40 Suppl A():9-14.
2003: George Sachs
Physiology of the parietal cell and therapeutic implications.
Pharmacotherapy 2003;23(10 Pt 2):68S-73S.
2003: Yi Wen; Elizabeth A Marcus; Uday Matrubutham; Martin A Gleeson; David R Scott; George Sachs
Acid-adaptive genes of Helicobacter pylori.
Infection and immunity 2003;71(10):5921-39.
2003: Olga Vagin; Svetlana Denevich; George Sachs
Plasma membrane delivery of the gastric H,K-ATPase: the role of beta-subunit glycosylation.
American journal of physiology. Cell physiology 2003;285(4):C968-76.
2003: Olga Vagin; Keith Munson; Svetlana Denevich; George Sachs
Inhibition kinetics of the gastric H,K-ATPase by K-competitive inhibitor SCH28080 as a tool for investigating the luminal ion pathway.
Annals of the New York Academy of Sciences 2003;986():111-5.
2003: Keith Munson; Olga Vagin; George Sachs; Steven J D Karlish
Molecular modeling of SCH28080 binding to the gastric H,K-ATPase and MgATP interactions with SERCA- and Na,K-ATPases.
Annals of the New York Academy of Sciences 2003;986():106-10.
2003: George Sachs; Jai Shin; V Pratha; D Hogan
Synthesis or rupture: duration of acid inhibition by proton pump inhibitors.
Drugs of today (Barcelona, Spain : 1998) 2003;39 Suppl A():11-4.
2003: Wu Hong; Kouichi Sano; Shinichi Morimatsu; David R Scott; David L Weeks; George Sachs; Toshiyuki Goto; Sharad Mohan; Fumiue Harada; Norihito Nakajima; Takashi Nakano
Medium pH-dependent redistribution of the urease of Helicobacter pylori.
Journal of medical microbiology 2003;52(Pt 3):211-6.
2003: Sergei Tatishchev; Natalia Abuladze; Alexander Pushkin; Debra Newman; Weixin Liu; David Weeks; George Sachs; Ira Kurtz
Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation.
Biochemistry 2003;42(3):755-65.
2003: George Sachs; David L Weeks; Klaus Melchers; David R Scott
The gastric biology of Helicobacter pylori.
Annual review of physiology 2003;65():349-69.
2003: Petra Voland; David L Weeks; Elizabeth A Marcus; Christian Prinz; George Sachs; David Scott
Interactions among the seven Helicobacter pylori proteins encoded by the urease gene cluster.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(1):G96-G106.
2002: S Hallén; A Björquist; A M Ostlund-Lindqvist; George Sachs
Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor.
Biochemistry 2002;41(50):14916-24.
2002: George Sachs; Jai Shin; Olga Vagin; Keith Munson; David Weeks; David R Scott; Petra Voland
Current trends in the treatment of upper gastrointestinal disease.
Best practice & research. Clinical gastroenterology 2002;16(6):835-49.
2002: Jai Shin; George Sachs
Restoration of acid secretion following treatment with proton pump inhibitors.
Gastroenterology 2002;123(5):1588-97.
2002: Nayoung Kim; David L Weeks; Jai Shin; David R Scott; Mary K Young; George Sachs
Proteins released by Helicobacter pylori in vitro.
Journal of bacteriology 2002;184(22):6155-62.
2002: Olga Vagin; Svetlana Denevich; Keith Munson; George Sachs
SCH28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain.
Biochemistry 2002;41(42):12755-62.
2002: Guy Patchornik; Keith Munson; Rivka Goldshleger; Alla Shainskaya; George Sachs; Steven J D Karlish
The ATP-Mg2+ binding site and cytoplasmic domain interactions of Na+,K+-ATPase investigated with Fe2+-catalyzed oxidative cleavage and molecular modeling.
Biochemistry 2002;41(39):11740-9.
2002: David R Scott; Elizabeth A Marcus; David L Weeks; George Sachs
Mechanisms of acid resistance due to the urease system of Helicobacter pylori.
Gastroenterology 2002;123(1):187-95.
2002: S Hallén; O Mareninova; M Brändén; George Sachs
Organization of the membrane domain of the human liver sodium/bile acid cotransporter.
Biochemistry 2002;41(23):7253-66.
2002: George Sachs; David Scott; David Weeks; Klaus Melchers
The compartment buffered by the urease of Helicobacter pylori: cytoplasm or periplasm?
Trends in microbiology 2002;10(5):217-8; author reply 218-9.
2002: Petra Voland; David L Weeks; D Vaira; Christian Prinz; George Sachs
Specific identification of three low molecular weight membrane-associated antigens of Helicobacter pylori.
Alimentary pharmacology & therapeutics 2002;16(3):533-44.
2001: J M Shin; Rivka Goldshleger; Keith Munson; George Sachs; Steven J D Karlish
Selective Fe2+-catalyzed oxidative cleavage of gastric H+,K+-ATPase: implications for the energy transduction mechanism of P-type cation pumps.
The Journal of biological chemistry 2001;276(51):48440-50.
2001: George Sachs; David Scott; David Weeks; Klaus Melchers
The importance of the surface urease of Helicobacter pylori: fact or fiction?
Trends in microbiology 2001;9(11):532-4.
2001: Olga Vagin; Keith Munson; Nils W G Lambrecht; Steven J D Karlish; George Sachs
Mutational analysis of the K+-competitive inhibitor site of gastric H,K-ATPase.
Biochemistry 2001;40(25):7480-90.
2001: D L Weeks; George Sachs
Sites of pH regulation of the urea channel of Helicobacter pylori.
Molecular microbiology 2001;40(6):1249-59.
2001: George Sachs
Improving on PPI-based therapy of GORD.
European journal of gastroenterology & hepatology 2001;13 Suppl 1():S35-41.
2000: George Sachs; David Scott; David Weeks; Klaus Melchers
Gastric habitation by Helicobacter pylori: insights into acid adaptation.
Trends in pharmacological sciences 2000;21(11):413-6.
2000: George Sachs; Jai Shin; Keith Munson; Olga Vagin; Nils W G Lambrecht; David R Scott; David L Weeks; Klaus Melchers
Review article: the control of gastric acid and Helicobacter pylori eradication.
Alimentary pharmacology & therapeutics 2000;14(11):1383-401.
2000: C Athmann; N Zeng; David R Scott; George Sachs
Regulation of parietal cell calcium signaling in gastric glands.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(5):G1048-58.
2000: Wu Hong; Shinichi Morimatsu; Toshiyuki Goto; George Sachs; David R Scott; David L Weeks; Takehiro Kohno; Chizuko Morita; Takashi Nakano; Y Fujioka; Kouichi Sano
Contrast-enhanced immunoelectron microscopy for Helicobacter pylori.
Journal of microbiological methods 2000;42(2):121-7.
2000: C Athmann; N Zeng; T Kang; Elizabeth A Marcus; David R Scott; M Rektorschek; A Buhmann; Klaus Melchers; George Sachs
Local pH elevation mediated by the intrabacterial urease of Helicobacter pylori cocultured with gastric cells.
The Journal of clinical investigation 2000;106(3):339-47.
2000: David Scott; David Weeks; Klaus Melchers; George Sachs
UreI-mediated urea transport in Helicobacter pylori: an open and shut case?
Trends in microbiology 2000;8(8):348-9.
2000: Mirza Zizak; Megan Cavet; D Bayle; Chung-Ming Tse; S Hallen; George Sachs; Mark Donowitz
Na(+)/H(+) exchanger NHE3 has 11 membrane spanning domains and a cleaved signal peptide: topology analysis using in vitro transcription/translation.
Biochemistry 2000;39(27):8102-12.
2000: M Rektorschek; A Buhmann; David Weeks; D Schwan; Klaus W Bensch; S Eskandari; David Scott; George Sachs; Klaus Melchers
Acid resistance of Helicobacter pylori depends on the UreI membrane protein and an inner membrane proton barrier.
Molecular microbiology 2000;36(1):141-52.
2000: Keith Munson; N Lambrecht; George Sachs
Effects of mutations in M4 of the gastric H+,K+-ATPase on inhibition kinetics of SCH28080.
Biochemistry 2000;39(11):2997-3004.
2000: Nils W G Lambrecht; Keith Munson; Olga Vagin; George Sachs
Comparison of covalent with reversible inhibitor binding sites of the gastric H,K-ATPase by site-directed mutagenesis.
The Journal of biological chemistry 2000;275(6):4041-8.
2000: Y Wen; George Sachs; C Athmann
A novel lens epithelium gene, LEP503, is highly conserved in different vertebrate species and is developmentally regulated in postnatal rat lens.
Experimental eye research 2000;70(2):159-68.
2000: David R Scott; Elizabeth A Marcus; David L Weeks; A Lee; Klaus Melchers; George Sachs
Expression of the Helicobacter pylori ureI gene is required for acidic pH activation of cytoplasmic urease.
Infection and immunity 2000;68(2):470-7.
2000: David L Weeks; Sepehr Eskandari; David R Scott; George Sachs
A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonization.
Science (New York, N.Y.) 2000;287(5452):482-5.
2000: Joseph R Pisegna; Gordon V Ohning; C Athmann; N Zeng; John H Walsh; George Sachs
Role of PACAP1 receptor in regulation of ECL cells and gastric acid secretion by pituitary adenylate cyclase activating peptide.
Annals of the New York Academy of Sciences 2000;921():233-41.
2000: Keith Munson; Nils W G Lambrecht; Jai Shin; George Sachs
Analysis of the membrane domain of the gastric H(+)/K(+)-ATPase.
The Journal of experimental biology 2000;203(Pt 1):161-70.
1999: N Zeng; C Athmann; T Kang; John H Walsh; George Sachs
Role of neuropeptide-sensitive L-type Ca(2+) channels in histamine release in gastric enterochromaffin-like cells.
The American journal of physiology 1999;277(6 Pt 1):G1268-80.
1999: N Zeng; C Athmann; T Kang; RM Lyu; John H Walsh; Gordon V Ohning; George Sachs; Joseph R Pisegna
PACAP type I receptor activation regulates ECL cells and gastric acid secretion.
The Journal of clinical investigation 1999;104(10):1383-91.
1999: S Hallén; M Brändén; P A Dawson; George Sachs
Membrane insertion scanning of the human ileal sodium/bile acid co-transporter.
Biochemistry 1999;38(35):11379-88.
1999: George Sachs; TJ Humphries
Rabeprazole: pharmacology, pharmacokinetics, and potential for drug interactions. Introduction.
Alimentary pharmacology & therapeutics 1999;13 Suppl 3():1-2.
1999: Y Wen; J L Edelman; T Kang; George Sachs
Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1.
Biochemical and biophysical research communications 1999;258(3):713-21.
1999: George Sachs
Acid inhibition and gastroesophageal reflux disease.
The Yale journal of biology and medicine 1999;72(2-3):227-9.
1998: N Zeng; T Kang; RM Lyu; Helen Wong; Y Wen; John H Walsh; George Sachs; Joseph R Pisegna
The pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1-R) is expressed on gastric ECL cells: evidence by immunocytochemistry and RT-PCR.
Annals of the New York Academy of Sciences 1998;865():147-56.
1998: M Rektorschek; David Weeks; George Sachs; Klaus Melchers
Influence of pH on metabolism and urease activity of Helicobacter pylori.
Gastroenterology 1998;115(3):628-41.
1998: D Melle-Milovanovic; Nils W G Lambrecht; George Sachs; Jai Shin
Structural aspects of the gastric H,K ATPase: the M5/M6 domain and alpha beta association.
Acta physiologica Scandinavica. Supplementum 1998;643():147-62.
1998: Klaus Melchers; L Herrmann; F Mauch; D Bayle; D Heuermann; T Weitzenegger; Alexander Schuhmacher; George Sachs; R Haas; G Bode; Klaus W Bensch; Klaus P Schäfer
Properties and function of the P type ion pumps cloned from Helicobacter pylori.
Acta physiologica Scandinavica. Supplementum 1998;643():123-35.
1998: N Zeng; T Kang; Y Wen; Helen Wong; J Walsh; George Sachs
Galanin inhibition of enterochromaffin-like cell function.
Gastroenterology 1998;115(2):330-9.
1998: David Scott; David Weeks; Klaus Melchers; George Sachs
The life and death of Helicobacter pylori.
Gut 1998;43 Suppl 1():S56-60.
1998: Nils W G Lambrecht; Z Corbett; D Bayle; Steven J D Karlish; George Sachs
Identification of the site of inhibition by omeprazole of a alpha-beta fusion protein of the H,K-ATPase using site-directed mutagenesis.
The Journal of biological chemistry 1998;273(22):13719-28.
1998: D Melle-Milovanovic; M Milovanovic; S Nagpal; George Sachs; Jai Shin
Regions of association between the alpha and the beta subunit of the gastric H,K-ATPase.
The Journal of biological chemistry 1998;273(18):11075-81.
1998: Y Wen; J L Edelman; T Kang; N Zeng; George Sachs
Two functional forms of vascular endothelial growth factor receptor-2/Flk-1 mRNA are expressed in normal rat retina.
The Journal of biological chemistry 1998;273(4):2090-7.
1998: D Bayle; S Wängler; T Weitzenegger; Wolfram Steinhilber; J Volz; M Przybylski; Klaus P Schäfer; George Sachs; Klaus Melchers
Properties of the P-type ATPases encoded by the copAP operons of Helicobacter pylori and Helicobacter felis.
Journal of bacteriology 1998;180(2):317-29.
1998: David R Scott; David Weeks; C Hong; S Postius; Klaus Melchers; George Sachs
The role of internal urease in acid resistance of Helicobacter pylori.
Gastroenterology 1998;114(1):58-70.
1997: Jai Shin; M Besancon; K Bamberg; George Sachs
Structural aspects of the gastric H,K ATPase.
Annals of the New York Academy of Sciences 1997;834():65-76.
1997: M Besancon; A Simon; George Sachs; Jai Shin
Sites of reaction of the gastric H,K-ATPase with extracytoplasmic thiol reagents.
The Journal of biological chemistry 1997;272(36):22438-46.
1997: D Bayle; David Weeks; George Sachs
Identification of membrane insertion sequences of the rabbit gastric cholecystokinin-A receptor by in vitro translation.
The Journal of biological chemistry 1997;272(32):19697-707.
1997: George Sachs; K Meyer-Rosberg; David R Scott; Klaus Melchers; J Shin; M Besancon
Acid secretion and Helicobacter pylori.
Digestion 1997;58 Suppl 1():8-13.
1997: George Sachs; N Zeng; C Prinz
Physiology of isolated gastric endocrine cells.
Annual review of physiology 1997;59():243-56.
1997: D Bayle; David Weeks; S Hallen; Klaus Melchers; K Bamberg; George Sachs
In vitro translation analysis of integral membrane proteins.
Journal of receptor and signal transduction research 1997;17(1-3):29-56.
1997: George Sachs
Proton pump inhibitors and acid-related diseases.
Pharmacotherapy 1997;17(1):22-37.
1997: N Zeng; John H Walsh; T Kang; S Vincent Wu; George Sachs
Peptide YY inhibition of rat gastric enterochromaffin-like cell function.
Gastroenterology 1997;112(1):127-35.
1996: K Meyer-Rosberg; David R Scott; D Rex; Klaus Melchers; George Sachs
The effect of environmental pH on the proton motive force of Helicobacter pylori.
Gastroenterology 1996;111(4):886-900.
1996: K G Helander; K Bamberg; George Sachs; D Melle; Herbert F Helander
Localization of mRNA for the muscarinic M1 receptor in rat stomach.
Biochimica et biophysica acta 1996;1312(2):158-62.
1996: N Zeng; John H Walsh; T Kang; K G Helander; Herbert F Helander; George Sachs
Selective ligand-induced intracellular calcium changes in a population of rat isolated gastric endocrine cells.
Gastroenterology 1996;110(6):1835-46.
1996: George Sachs; K Meyer-Rosberg; David R Scott; Klaus Melchers
Acid, protons and Helicobacter pylori.
The Yale journal of biology and medicine 1996;69(3):301-16.
1996: Donald D F Loo; George Sachs; C Prinz
Potassium and chloride currents in rat gastric enterochromaffin-like cells.
The American journal of physiology 1996;270(5 Pt 1):E739-45.
1996: Klaus Melchers; T Weitzenegger; A Buhmann; Wolfram Steinhilber; George Sachs; Klaus P Schäfer
Cloning and membrane topology of a P type ATPase from Helicobacter pylori.
The Journal of biological chemistry 1996;271(1):446-57.
1995: D Bayle; David Weeks; George Sachs
The membrane topology of the rat sarcoplasmic and endoplasmic reticulum calcium ATPases by in vitro translation scanning.
The Journal of biological chemistry 1995;270(43):25678-84.
1995: K Gedda; D Scott; M Besancon; P Lorentzon; George Sachs
Turnover of the gastric H+,K(+)-adenosine triphosphatase alpha subunit and its effect on inhibition of rat gastric acid secretion.
Gastroenterology 1995;109(4):1134-41.
1995: George Sachs
Progress in therapy of ulcer disease.
Bildgebung = Imaging 1995;62 Suppl 1():76.
1995: B I Hirschowitz; D Keeling; M Lewin; S Okabe; M Parsons; K Sewing; B Wallmark; George Sachs
Pharmacological aspects of acid secretion.
Digestive diseases and sciences 1995;40(2 Suppl):3S-23S.
1995: S J Hersey; George Sachs
Gastric acid secretion.
Physiological reviews 1995;75(1):155-89.
1995: George Sachs; Jai Shin; C Briving; B Wallmark; S Hersey
The pharmacology of the gastric acid pump: the H+,K+ ATPase.
Annual review of pharmacology and toxicology 1995;35():277-305.
1994: M Reuben; L Rising; C Prinz; S Hersey; George Sachs
Cloning and expression of the rabbit gastric CCK-A receptor.
Biochimica et biophysica acta 1994;1219(2):321-7.
1994: David R Scott; M Besancon; George Sachs; Herbert F Helander
Effects of antisecretory agents on parietal cell structure and H/K-ATPase levels in rabbit gastric mucosa in vivo.
Digestive diseases and sciences 1994;39(10):2118-26.
1994: C Prinz; D R Scott; D Hurwitz; Herbert F Helander; George Sachs
Gastrin effects on isolated rat enterochromaffin-like cells in primary culture.
The American journal of physiology 1994;267(4 Pt 1):G663-75.
1994: C Prinz; George Sachs; John H Walsh; David H Coy; S Vincent Wu
The somatostatin receptor subtype on rat enterochromaffinlike cells.
Gastroenterology 1994;107(4):1067-74.
1994: George Sachs; C Prinz; Donald D F Loo; K Bamberg; M Besancon; Jai Shin
Gastric acid secretion: activation and inhibition.
The Yale journal of biology and medicine 1994;67(3-4):81-95.
1994: K Bamberg; sven nylander; K G Helander; L G Lundberg; George Sachs; Herbert F Helander
In situ hybridization of mRNA for the gastric H+,K(+)-ATPase in rat oxyntic mucosa.
Biochimica et biophysica acta 1994;1190(2):355-9.
1994: Akira Tari; G Yamamoto; Y Yonei; M Sumii; Koji Sumii; Ken Haruma; Goro Kajiyama; V Wu; George Sachs; John H Walsh
Effect of histamine on rat gastric H(+)-K(+)-ATPase alpha-subunit expression.
The American journal of physiology 1994;266(3 Pt 1):G444-50.
1994: Jai Shin; M Besancon; C Prinz; A Simon; George Sachs
Continuing development of acid pump inhibitors: site of action of pantoprazole.
Alimentary pharmacology & therapeutics 1994;8 Suppl 1():11-23.
1993: D R Scott; S J Hersey; C Prinz; George Sachs
Actions of antiulcer drugs.
Science (New York, N.Y.) 1993;262(5138):1453-4; author reply 1454-5.
1993: Akira Tari; G Yamamoto; Koji Sumii; M Sumii; Y Takehara; Ken Haruma; Goro Kajiyama; V Wu; George Sachs; John H Walsh
Role of histamine2 receptor in increased expression of rat gastric H(+)-K(+)-ATPase alpha-subunit induced by omeprazole.
The American journal of physiology 1993;265(4 Pt 1):G752-8.
1993: C Prinz; M Kajimura; D R Scott; F Mercier; Herbert F Helander; George Sachs
Histamine secretion from rat enterochromaffinlike cells.
Gastroenterology 1993;105(2):449-61.
1993: Jai Shin; M Besancon; A Simon; George Sachs
The site of action of pantoprazole in the gastric H+/K(+)-ATPase.
Biochimica et biophysica acta 1993;1148(2):223-33.
1993: stéphane supplisson; Donald D F Loo; George Sachs
Whole-cell currents in isolated resting Necturus gastric oxynticopeptic cells.
The Journal of physiology 1993;463():57-82.
1993: M Besancon; Jai Shin; F Mercier; K Munson; M Miller; S Hersey; George Sachs
Membrane topology and omeprazole labeling of the gastric H+,K(+)-adenosinetriphosphatase.
Biochemistry 1993;32(9):2345-55.
1993: D R Scott; Herbert F Helander; S J Hersey; George Sachs
The site of acid secretion in the mammalian parietal cell.
Biochimica et biophysica acta 1993;1146(1):73-80.
1993: George Sachs; Jai Shin; M Besancon; C Prinz
The continuing development of gastric acid pump inhibitors.
Alimentary pharmacology & therapeutics 1993;7 Suppl 1():4-12, discussion 29-31.
1992: D R Scott; K Munson; N Modyanov; George Sachs
Determination of the sidedness of the C-terminal region of the gastric H,K-ATPase alpha subunit.
Biochimica et biophysica acta 1992;1112(2):246-50.
1992: George Sachs; Jai Shin; M Besancon; K Munson; S Hersey
Topology and sites in the H,K-ATPase.
Annals of the New York Academy of Sciences 1992;671():204-16.
1992: C Prinz; M Kajimura; D Scott; Herbert F Helander; J Shin; M Besancon; K Bamberg; S Hersey; George Sachs
Acid secretion and the H,K ATPase of stomach.
The Yale journal of biology and medicine 1992;65(6):577-96.
1992: D Bayle; Jean-Claude Robert; K Bamberg; F Benkouka; A M Cheret; MJ Lewin; George Sachs; A Soumarmon
Location of the cytoplasmic epitope for a K(+)-competitive antibody of the (H+,K+)-ATPase.
The Journal of biological chemistry 1992;267(27):19060-5.
1992: George Sachs; M Besancon; Jai Shin; F Mercier; K Munson; S Hersey
Structural aspects of the gastric H,K-ATPase.
Journal of bioenergetics and biomembranes 1992;24(3):301-8.
1992: K Bamberg; F Mercier; M A Reuben; Y Kobayashi; K B Munson; George Sachs
cDNA cloning and membrane topology of the rabbit gastric H+/K(+)-ATPase alpha-subunit.
Biochimica et biophysica acta 1992;1131(1):69-77.
1992: M Besancon; Jai Shin; F Mercier; K Munson; E Rabon; S Hersey; George Sachs
Chemomechanical coupling in the gastric H,K ATPase.
Acta physiologica Scandinavica. Supplementum 1992;607():77-88.
1992: E C Rabon; George Sachs; C A Leach; D Keeling
A K+ competitive, conformational probe of the H,K-ATPase.
Acta physiologica Scandinavica. Supplementum 1992;607():269-73.
1991: Akira Tari; V Wu; M Sumii; George Sachs; John H Walsh
Regulation of rat gastric H+/K(+)-ATPase alpha-subunit mRNA by omeprazole.
Biochimica et biophysica acta 1991;1129(1):49-56.
1991: K B Munson; C Gutierrez; V N Balaji; Kalyanaraman Ramnarayan; George Sachs
Identification of an extracytoplasmic region of H+,K(+)-ATPase labeled by a K(+)-competitive photoaffinity inhibitor.
The Journal of biological chemistry 1991;266(28):18976-88.
1991: stéphane supplisson; Donald D F Loo; George Sachs
Diversity of K+ channels in the basolateral membrane of resting Necturus oxyntic cells.
The Journal of membrane biology 1991;123(3):209-21.
1991: E Rabon; George Sachs; S Bassilian; C Leach; D Keeling
A K(+)-competitive fluorescent inhibitor of the H,K-ATPase.
The Journal of biological chemistry 1991;266(19):12395-401.
1991: J M Wilkes; M Kajimura; D R Scott; S J Hersey; George Sachs
Muscarinic responses of gastric parietal cells.
The Journal of membrane biology 1991;122(2):97-110.
1991: K Hall; G Perez; George Sachs; E Rabon
Identification of H+/K(+)-ATPase alpha,beta-heterodimers.
Biochimica et biophysica acta 1991;1077(2):173-9.
1991: J M Wilkes; D R Scott; S J Hersey; George Sachs
Second messengers in the gastric gland: a focus on calcium.
Scandinavian journal of gastroenterology. Supplement 1991;180():70-84.
1990: George Sachs; K Munson; K Hall; S J Hersey
Gastric H+,K(+)-ATPase as a therapeutic target in peptic ulcer disease.
Digestive diseases and sciences 1990;35(12):1537-44.
1990: E C Rabon; S Bassilian; George Sachs; S J Karlish
Conformational transitions of the H,K-ATPase studied with sodium ions as surrogates for protons.
The Journal of biological chemistry 1990;265(32):19594-9.
1990: D Scott; M Reuben; G Zampighi; George Sachs
Cell isolation and genotoxicity assessment in gastric mucosa.
Digestive diseases and sciences 1990;35(10):1217-25.
1990: J Mendlein; M L Ditmars; George Sachs
Calcium binding to the H+,K(+)-ATPase. Evidence for a divalent cation site that is occupied during the catalytic cycle.
The Journal of biological chemistry 1990;265(26):15590-8.
1990: J Fryklund; K Gedda; D Scott; George Sachs; B Wallmark
Coupling of H(+)-K(+)-ATPase activity and glucose oxidation in gastric glands.
The American journal of physiology 1990;258(5 Pt 1):G719-27.
1990: J Mendlein; George Sachs
Interaction of a K(+)-competitive inhibitor, a substituted imidazo[1,2a] pyridine, with the phospho- and dephosphoenzyme forms of H+, K(+)-ATPase.
The Journal of biological chemistry 1990;265(9):5030-6.
1990: K Hall; G Perez; D Anderson; C Gutierrez; K Munson; S J Hersey; Jack H Kaplan; George Sachs
Location of the carbohydrates present in the HK-ATPase vesicles isolated from hog gastric mucosa.
Biochemistry 1990;29(3):701-6.
1990: B Wallmark; P Lorentzon; George Sachs
The gastric H+,K(+)-ATPase.
Journal of internal medicine. Supplement 1990;732():3-8.
1990: George Sachs; D Scott; M Reuben
Omeprazole and the gastric mucosa.
Digestion 1990;47 Suppl 1():35-8.
1990: George Sachs; D Scott
Cell digestion and genotoxicity assessment in gastric mucosa.
Digestion 1990;47 Suppl 1():31-4.
1990: George Sachs; E Rabon; S J Karlish
Transport studies by optical methods.
Methods in enzymology 1990;191():469-79.
1990: Emeran Mayer; Donald D F Loo; W J Snape; George Sachs
The activation of calcium and calcium-activated potassium channels in mammalian colonic smooth muscle by substance P.
The Journal of physiology 1990;420():47-71.
1989: J Mendlein; George Sachs
The substitution of calcium for magnesium in H+,K+-ATPase catalytic cycle. Evidence for two actions of divalent cations.
The Journal of biological chemistry 1989;264(31):18512-9.
1989: George Sachs; K Munson; V N Balaji; D Aures-Fischer; S J Hersey; K Hall
Functional domains of the gastric HK ATPase.
Journal of bioenergetics and biomembranes 1989;21(5):573-88.
1989: S J Hersey; A Perez; S Matheravidathu; George Sachs
Gastric H+-K+-ATPase in situ: evidence for compartmentalization.
The American journal of physiology 1989;257(4 Pt 1):G539-47.
1989: Herbert F Helander; D Anderson; K G Helander; Adam J Smolka; George Sachs
Immunocytochemical studies of gastric H+,K+-ATPase in the developing rat.
Scandinavian journal of gastroenterology 1989;24(7):863-9.
1989: George Sachs; Shmuel Muallem
Sites and mechanisms of Ca2+ movement in non-excitable cells.
Cell calcium 1989;10(5):265-73.
1989: A Perez; D Blissard; George Sachs; S J Hersey
Evidence for a chloride conductance in secretory membrane of parietal cells.
The American journal of physiology 1989;256(2 Pt 1):G299-305.
1989: P Lorentzon; S J Hersey; B Wallmark; George Sachs
Ion permeability and pump regulation.
Annals of the New York Academy of Sciences 1989;574():134-44.
1988: Danuta H Malinowska; George Sachs; John Cuppoletti
Gastric H+ secretion: histamine (cAMP-mediated) activation of protein phosphorylation.
Biochimica et biophysica acta 1988;972(1):95-109.
1988: S J Hersey; L Steiner; J Mendlein; E Rabon; George Sachs
SCH28080 prevents omeprazole inhibition of the gastric H+/K+-ATPase.
Biochimica et biophysica acta 1988;956(1):49-57.
1988: P Lorentzon; George Sachs; B Wallmark
Inhibitory effects of cations on the gastric H+, K+ -ATPase. A potential-sensitive step in the K+ limb of the pump cycle.
The Journal of biological chemistry 1988;263(22):10705-10.
1988: S J Hersey; L Steiner; S Matheravidathu; George Sachs
Gastric H+-K+-ATPase in situ: relation to secretory state.
The American journal of physiology 1988;254(6 Pt 1):G856-63.
1988: K B Munson; George Sachs
Inactivation of H+,K+-ATPase by a K+-competitive photoaffinity inhibitor.
Biochemistry 1988;27(11):3932-8.
1988: George Sachs; Shmuel Muallem; S J Hersey
Passive and active transport in the parietal cell.
Comparative biochemistry and physiology. A, Comparative physiology 1988;90(4):727-31.
1988: P Lorentzon; D Scott; S Hersey; B Wallmark; E Rabon; George Sachs
The gastric H+,K+-ATPase.
Progress in clinical and biological research 1988;273():247-54.
1987: B Wallmark; C Briving; J Fryklund; K Munson; R Jackson; J Mendlein; E Rabon; George Sachs
Inhibition of gastric H+,K+-ATPase and acid secretion by SCH 28080, a substituted pyridyl(1,2a)imidazole.
The Journal of biological chemistry 1987;262(5):2077-84.
1987: P Lorentzon; R Jackson; B Wallmark; George Sachs
Inhibition of (H+ + K+)-ATPase by omeprazole in isolated gastric vesicles requires proton transport.
Biochimica et biophysica acta 1987;897(1):41-51.
1985: E Rabon; R D Gunther; A Soumarmon; S Bassilian; M Lewin; George Sachs
Solubilization and reconstitution of the gastric H,K-ATPase.
The Journal of biological chemistry 1985;260(18):10200-7.
1983: Adam J Smolka; Herbert F Helander; George Sachs
Monoclonal antibodies against gastric H+ + K+ ATPase.
The American journal of physiology 1983;245(4):G589-96.
1983: Danuta H Malinowska; John Cuppoletti; George Sachs
Cl- requirement of acid secretion in isolated gastric glands.
The American journal of physiology 1983;245(4):G573-81.
1983: L D Faller; E Rabon; George Sachs
Vanadate binding to the gastric H,K-ATPase and inhibition of the enzyme's catalytic and transport activities.
Biochemistry 1983;22(20):4676-85.
1983: E Rabon; J Cuppoletti; Danuta H Malinowska; Adam J Smolka; Herbert F Helander; J Mendlein; George Sachs
Proton secretion by the gastric parietal cell.
The Journal of experimental biology 1983;106():119-33.
1983: B Wallmark; George Sachs; S Mardh; E Fellenius
Inhibition of gastric (H+ + K+)-ATPase by the substituted benzimidazole, picoprazole.
Biochimica et biophysica acta 1983;728(1):31-8.
1982: E Rabon; George Sachs; Sven Mårdh; B Wallmark
ATP/ADP exchange activity of gastric (H+ +K+)-ATPase.
Biochimica et biophysica acta 1982;688(2):515-24.
1982: George Sachs; L D Faller; E Rabon
Proton/hydroxyl transport in gastric and intestinal epithelia.
The Journal of membrane biology 1982;64(3):123-35.
1982: L Faller; R Jackson; Danuta H Malinowska; E Mukidjam; E Rabon; G Saccomani; George Sachs; Adam J Smolka
Mechanistic aspects of gastric (H+ + K+)-ATPase.
Annals of the New York Academy of Sciences 1982;402():146-63.
1981: G Saccomani; M L Barcellona; George Sachs
Reactivity of gastric (H+ + K+)-ATPase to N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline.
The Journal of biological chemistry 1981;256(23):12405-10.
1981: E Fellenius; T Berglindh; George Sachs; Lars Olbe; B Elander; S E Sjöstrand; B Wallmark
Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase.
Nature 1981;290(5802):159-61.
1981: L D Faller; Danuta H Malinowska; E Rabon; Adam J Smolka; George Sachs
Mechanistic studies of the gastric (H+ + K)-ATPase.
Progress in clinical and biological research 1981;73():153-74.
1980: B Wallmark; H B Stewart; E Rabon; G Saccomani; George Sachs
The catalytic cycle of gastric (H+ + K+)-ATPase.
The Journal of biological chemistry 1980;255(11):5313-9.
1980: George Sachs; T Berglindh; E Rabon; B Wallmark; M L Barcellona; H B Stewart; G Saccomani
The interaction of K+ with gastric parietal cells and gastric ATPase.
Annals of the New York Academy of Sciences 1980;358():118-37.
1980: George Sachs; T Berglindh; E Rabon; H B Stewart; M L Barcellona; B Wallmark; G Saccomani
Aspects of parietal cell biology: cells and vesicles.
Annals of the New York Academy of Sciences 1980;341():312-34.