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Wolfgang Sadee

Research Profile

Occupations

Pharmacogenetics

Genes & Molecular Sequences

Chemicals & Drugs

Physiology

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Publications

TOP 3
Amy Webb; Jonathan C Sanford; Kun Huang; Audrey C Papp; Jeffrey D Parvin; Wolfgang Sadee
Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver.
Ryan M Smith; Amy Webb; Joel E Kleinman; Barbara K Lipska; Leanne M Munsie; Laura K Nisenbaum; Audrey C Papp; Cara L Ruble; Wolfgang Sadee
Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex.
Wenrui Duan; Li Gao; Marino Leon; Gregory A Otterson; Bhuvaneswari Ramaswamy; Kimberly Resnick; Wolfgang Sadee; Charles Shapiro; Paul R Andreassen; David E Cohn; Amy Webb; Xin Wu; Weiqiang Zhao; Miguel A Villalona-Calero
Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents.

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All Publications

2013: Amy Webb; Jonathan C Sanford; Kun Huang; Audrey C Papp; Jeffrey D Parvin; Wolfgang Sadee
Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver.
Pharmacogenetics and genomics 2013;23(5):269-78.
2013: Ryan M Smith; Amy Webb; Joel E Kleinman; Barbara K Lipska; Leanne M Munsie; Laura K Nisenbaum; Audrey C Papp; Cara L Ruble; Wolfgang Sadee
Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex.
Biological psychiatry 2013;73(6):546-54.
2013: Wenrui Duan; Li Gao; Marino Leon; Gregory A Otterson; Bhuvaneswari Ramaswamy; Kimberly Resnick; Wolfgang Sadee; Charles Shapiro; Paul R Andreassen; David E Cohn; Amy Webb; Xin Wu; Weiqiang Zhao; Miguel A Villalona-Calero
Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents.
Translational research : the journal of laboratory and clinical medicine 2013;161(3):156-64.
2013: Jonathan C Sanford; Yingying Guo; Wolfgang Sadee; Danxin Wang
Regulatory polymorphisms in CYP2C19 affecting hepatic expression.
Drug metabolism and drug interactions 2013;28(1):23-30.
2013: Joseph Paul Kitzmiller; Mitchell A Phelps; Danielle M Sullivan; Danxin Wang; Wolfgang Sadee
CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control.
Drug metabolism and drug interactions 2013;28(1):59-63.
2012: Wolfgang Sadee
The relevance of "missing heritability " in pharmacogenomics.
Clinical pharmacology and therapeutics 2012;92(4):428-30.
2012: Abul K Azad; Wolfgang Sadee; Larry S Schlesinger
Innate immune gene polymorphisms in tuberculosis.
Infection and immunity 2012;80(10):3343-59.
2012: Joseph P Kitzmiller; Kandamurugu Manickam; Clay B Marsh; Mitch A Phelps; Peter Joseph Embi; Rebecca D Jackson; Kevin M Sweet; Wolfgang Sadee
Program in pharmacogenomics at the Ohio State University Medical Center.
Pharmacogenomics 2012;13(7):751-6.
2012: Elizabeth S Barrie; Jonathan C Sanford; Ryan M Smith; Wolfgang Sadee
mRNA transcript diversity creates new opportunities for pharmacological intervention.
Molecular pharmacology 2012;81(5):620-30.
2012: Audrey C Papp; Carl J Pepine; Julia K Pinsonneault; Yan Gong; Aroon D Hingorani; Steve E Humphries; Julie A Johnson; Meena Kumari; Leslie C Newman; Sonia Shah; Philippa J Talmud; Danxin Wang; Wolfgang Sadee
Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk.
PloS one 2012;7(3):e31930.
2011: Danxin Wang; Susan L Koletar; Michael F Para; Wolfgang Sadee
Human N-acetyltransferase 1 *10 and *11 alleles increase protein expression through distinct mechanisms and associate with sulfamethoxazole-induced hypersensitivity.
Pharmacogenetics and genomics 2011;21(10):652-64.
2011: Wolfgang Sadee
Genomics and personalized medicine.
International journal of pharmaceutics 2011;415(1-2):2-4.
2011: Julia K Pinsonneault; Alessandro Bertolino; Katherine E Burdick; Howard H Gu; Dawn D Han; Maria Kataki; Anil Malhotra; Wolfgang Sadee
Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011;36(8):1644-55.
2011: Wolfgang Sadee
Pharmacogenomic biomarkers: validation needed for both the molecular genetic mechanism and clinical effect.
Pharmacogenomics 2011;12(5):675-80.
2011: Joseph P Kitzmiller; David K Groen; Mitch A Phelps; Wolfgang Sadee
Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others.
Cleveland Clinic journal of medicine 2011;78(4):243-57.
2011: Wolfgang Sadee; Danxin Wang; Audrey C Papp; Julia K Pinsonneault; R M Smith; R A Moyer; Andrew D Johnson
Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.
Clinical pharmacology and therapeutics 2011;89(3):355-65.
2011: Robert A Moyer; Danxin Wang; Audrey C Papp; Ryan M Smith; Linda Duque; Deborah C Mash; Wolfgang Sadee
Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011;36(4):753-62.
2011: Ryan M Smith; Wolfgang Sadee
Synaptic signaling and aberrant RNA splicing in autism spectrum disorders.
Frontiers in synaptic neuroscience 2011;3():1.
2011: Ryan M Smith; Houda Alachkar; Audrey C Papp; Danxin Wang; Deborah C Mash; Jen-Chyong Wang; Laura J Bierut; Wolfgang Sadee
Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms.
European journal of human genetics : EJHG 2011;19(1):76-83.
2010: Hui Wang; Matt Karikomi; Shan Naidu; Ravi Rajmohan; Enrico Caserta; Hui-Zi Chen; Maysoon Rawahneh; Julie Moffitt; Julie A Stephens; Soledad A Fernandez; Michael Weinstein; Danxin Wang; Wolfgang Sadee; Krista La Perle; Paul Stromberg; Thomas J Rosol; Charis Eng; Michael C Ostrowski; Gustavo Leone
Allele-specific tumor spectrum in pten knockin mice.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):5142-7.
2010: Elizabeth J Atkinson; Shannon K McDonnell; John S Witte; Dana C Crawford; Yiping Fan; Brooke Fridley; Dalin Li; Lang Li; Andrei Rodin; Wolfgang Sadee; Terry Speed; Scott T Weiss; Jun Yang; Laura Yerges-Armstrong; Daniel J Schaid
Conference Scene: Lessons learned from the 5th Statistical Analysis Workshop of the Pharmacogenetics Research Network.
Pharmacogenomics 2010;11(3):297-303.
2010: Wenjun Ni; Jia Ji; Zunyan Dai; Audrey Papp; Amy J Johnson; Sunjoo Ahn; Katherine L Farley; Thomas S Lin; James T Dalton; Xiaobai Li; David Jarjoura; John C Byrd; Wolfgang Sadee; Michael R Grever; Mitch A Phelps
Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.
PloS one 2010;5(11):e13792.
2010: Alessandro Bertolino; Paolo Taurisano; Nicola Marco Pisciotta; Giuseppe Blasi; Leonardo Fazio; Raffaella Romano; Barbara Gelao; Luciana Lo Bianco; Madia Lozupone; Annabella Di Giorgio; Grazia Caforio; Fabio Sambataro; Artor Niccoli-Asabella; Audrey Papp; Gianluca Ursini; Lorenzo Sinibaldi; teresa popolizio; Wolfgang Sadee; Giuseppe Rubini
Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance.
PloS one 2010;5(2):e9348.
2010: Wolfgang Sadee
Regulatory polymorphisms in key candidate genes for disease susceptibility and drug response: a mandate for valid genetic biomarkers.
Expert review of molecular diagnostics 2010;10(1):9-11.
2009: Giuseppe Blasi; Luciana Lo Bianco; Paolo Taurisano; Barbara Gelao; Raffaella Romano; Leonardo Fazio; Apostolos Papazacharias; Annabella Di Giorgio; Grazia Caforio; Antonio Rampino; Rita Masellis; Audrey Papp; Gianluca Ursini; Lorenzo Sinibaldi; teresa popolizio; Wolfgang Sadee; Alessandro Bertolino
Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(47):14812-9.
2009: Tanios Bekaii-Saab; Joseph Markowitz; Nichole Prescott; Wolfgang Sadee; Nyla A Heerema; Lai Wei; Zunyan Dai; Audrey Papp; Angela Campbell; Kristy Culler; Catherine Balint; Bert O Neil; Ruey-Min Lee; Mark M Zalupski; Janet Dancey; Helen Chen; Michael R Grever; Charis Eng; Miguel A Villalona-Calero
A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(18):5895-901.
2009: Amber L Beitelshees; Hrishikesh Navare; Danxin Wang; Yan Gong; Jennifer Wessel; James I Moss; Taimour Y Langaee; Rhonda M Cooper-DeHoff; Wolfgang Sadee; Carl J Pepine; Nicolas J Schork; Julie A Johnson
CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response.
Circulation. Cardiovascular genetics 2009;2(4):362-70.
2009: Alessandro Bertolino; Leonardo Fazio; Grazia Caforio; Giuseppe Blasi; Antonio Rampino; Raffaella Romano; Annabella Di Giorgio; Paolo Taurisano; Audrey Papp; Julia Pinsonneault; Danxin Wang; Marcello Nardini; teresa popolizio; Wolfgang Sadee
Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia.
Brain : a journal of neurology 2009;132(Pt 2):417-25.
2009: Alessandro Bertolino; Leonardo Fazio; Annabella Di Giorgio; Giuseppe Blasi; Raffaella Romano; Paolo Taurisano; Grazia Caforio; Lorenzo Sinibaldi; Gianluca Ursini; teresa popolizio; Emanuele Tirotta; Audrey Papp; Bruno Dallapiccola; Emiliana Borrelli; Wolfgang Sadee
Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(4):1224-34.
2009: Wolfgang Sadee
Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility.
Genome medicine 2009;1(12):116.
2009: Brian E Roe; Michael R Tilley; Howard H Gu; David Q Beversdorf; Wolfgang Sadee; Timothy C Haab; Audrey C Papp
Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
PloS one 2009;4(8):e6704.
2008: Houda Alachkar; Maria Kataki; Douglas W Scharre; Audrey Papp; Wolfgang Sadee
Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues.
Neuroscience letters 2008;448(1):120-4.
2008: Wolfgang Sadee
Drug therapy and personalized health care: pharmacogenomics in perspective.
Pharmaceutical research 2008;25(12):2713-9.
2008: Beth Besecker; Shengying Bao; Barbara Bohacova; Audrey Papp; Wolfgang Sadee; Daren L Knoell
The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia.
American journal of physiology. Lung cellular and molecular physiology 2008;294(6):L1127-36.
2008: Zunyan Dai; Audrey C Papp; Danxin Wang; Heather Hampel; Wolfgang Sadee
Genotyping panel for assessing response to cancer chemotherapy.
BMC medical genomics 2008;1():24.
2008: Paul E Blower; Ji-Hyun Chung; Joseph S Verducci; Shili Lin; Jong-Kook Park; Zunyan Dai; Chang-gong liu; Thomas D Schmittgen; William C Reinhold; Carlo M Croce; John N Weinstein; Wolfgang Sadee
MicroRNAs modulate the chemosensitivity of tumor cells.
Molecular cancer therapeutics 2008;7(1):1-9.
2007: Amber L Beitelshees; Yan Gong; Danxin Wang; Nicholas J Schork; Rhonda M Cooper-DeHoff; Taimour Y Langaee; Mark D Shriver; Wolfgang Sadee; Harry Knot; Carl J Pepine; Julie A Johnson
KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST).
Pharmacogenetics and genomics 2007;17(9):719-29.
2007: Paul E Blower; Joseph S Verducci; Shili Lin; Jin Zhou; Ji-Hyun Chung; Zunyan Dai; Chang-gong liu; William C Reinhold; Philip L Lorenzi; Eric P Kaldjian; Carlo M Croce; John N Weinstein; Wolfgang Sadee
MicroRNA expression profiles for the NCI-60 cancer cell panel.
Molecular cancer therapeutics 2007;6(5):1483-91.
2007: J-E Lim; Julia K Pinsonneault; Wolfgang Sadee; David Saffen
Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons.
Molecular psychiatry 2007;12(5):491-501.
2007: Danxin Wang; Xiaochun Sun; Wolfgang Sadee
Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment.
The Journal of pharmacology and experimental therapeutics 2007;321(2):544-52.
2007: Zunyan Dai; Ying Huang; Wolfgang Sadee; Paul E Blower
Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system xc-.
Journal of medicinal chemistry 2007;50(8):1896-906.
2007: Xianhua Cao; Lanyan Fang; Seth Gibbs; Ying Huang; Zunyan Dai; Ping Wen; Xincheng Zheng; Wolfgang Sadee; Duxin Sun
Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia.
Cancer chemotherapy and pharmacology 2007;59(4):495-505.
2006: Zunyan Dai; Shujun Liu; Guido Marcucci; Wolfgang Sadee
5-Aza-2'-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer).
Biochemical and biophysical research communications 2006;351(2):455-61.
2006: Yonghui Wang; Zunyan Dai; Wolfgang Sadee; William S Hancock
A pharmacoproteomics study of the cancer cell line EKVX using capillary-LC/MS/MS.
Molecular pharmaceutics 2006;3(5):566-78.
2006: Cecile Krejsa; Mark Rogge; Wolfgang Sadee
Protein therapeutics: new applications for pharmacogenetics.
Nature reviews. Drug discovery 2006;5(6):507-21.
2005: Natasha Y Frank; Armen Margaryan; Ying Huang; Tobias Schatton; Ana Maria Waaga-Gasser; Martin Gasser; Mohamed H Sayegh; Wolfgang Sadee; Markus Frank
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.
Cancer research 2005;65(10):4320-33.
2005: Andrew D Johnson; Danxin Wang; Wolfgang Sadee
Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics.
Pharmacology & therapeutics 2005;106(1):19-38.
2005: Jill B Becker; Arthur P Arnold; Karen J Berkley; Jeffrey D Blaustein; Lisa A Eckel; Elizabeth Hampson; James P Herman; Sherry A Marts; Wolfgang Sadee; Meir Steiner; Jane Taylor; Elizabeth Young
Strategies and methods for research on sex differences in brain and behavior.
Endocrinology 2005;146(4):1650-73.
2004: Christopher P Landowski; Pascale Anderle; Duxin Sun; Wolfgang Sadee; Gordon L Amidon
Transporter and ion channel gene expression after Caco-2 cell differentiation using 2 different microarray technologies.
The AAPS journal 2004;6(3):e21.
2003: Dana D Phan; Peter Chin-Hong; Emil T Lin; Pascale Anderle; Wolfgang Sadee; B Joseph Guglielmo
Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor.
Antimicrobial agents and chemotherapy 2003;47(7):2351-3.
2002: Wolfgang Sadee
Pharmacogenomics: the implementation phase.
AAPS pharmSci 2002;4(2):E5.
2001: Kathryn A Phillips; D L Veenstra; Eyal Oren; J K Lee; Wolfgang Sadee
Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review.
JAMA : the journal of the American Medical Association 2001;286(18):2270-9.
2000: Kathryn A Phillips; D L Veenstra; Wolfgang Sadee
Implications of the genetics revolution for health services research: pharmacogenomics and improvements in drug therapy.
Health services research 2000;35(5 Pt 3):128-40.
1998: NT Burford; LM Tolbert; Wolfgang Sadee
Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I.
European journal of pharmacology 1998;342(1):123-6.