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Sheila Sadeghi

Research Profile

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Chemicals & Drugs

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Desulfovibrio vulgaris

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Publications

TOP 3
Georgia Eleni Tsotsou; Loretta Lazzarato; Sheila J Sadeghi; Massimo Bertinaria; Giovanna Di Nardo; Roberta Fruttero; Gianfranco Gilardi
A rapid screening for cytochrome P450 catalysis on new chemical entities: cytochrome P450 BM3 and 1,2,5-oxadiazole derivatives.
Sheila J Sadeghi; Gianfranco Gilardi
Chimeric P450 enzymes: Activity of artificial redox fusions driven by different reductases for biotechnological applications.
Gianluca Catucci; Gianfranco Gilardi; Massimo Maffei; Andrea Occhipinti; Sheila J Sadeghi
Effect of human flavin-containing monooxygenase 3 polymorphism on the metabolism of aurora kinase inhibitors.

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All Publications

2013: Georgia Eleni Tsotsou; Loretta Lazzarato; Sheila J Sadeghi; Massimo Bertinaria; Giovanna Di Nardo; Roberta Fruttero; Gianfranco Gilardi
A rapid screening for cytochrome P450 catalysis on new chemical entities: cytochrome P450 BM3 and 1,2,5-oxadiazole derivatives.
Journal of biomolecular screening 2013;18(2):211-8.
2013: Sheila J Sadeghi; Gianfranco Gilardi
Chimeric P450 enzymes: Activity of artificial redox fusions driven by different reductases for biotechnological applications.
Biotechnology and applied biochemistry 2013;60(1):102-10.
2013: Gianluca Catucci; Gianfranco Gilardi; Massimo Maffei; Andrea Occhipinti; Sheila J Sadeghi
Effect of human flavin-containing monooxygenase 3 polymorphism on the metabolism of aurora kinase inhibitors.
International journal of molecular sciences 2013;14(2):2707-16.
2012: Silvia Castrignanò; Sheila J Sadeghi; Gianfranco Gilardi
Entrapment of human flavin-containing monooxygenase 3 in the presence of gold nanoparticles: TEM, FTIR and electrocatalysis.
Biochimica et biophysica acta 2012;1820(12):2072-8.
2012: Francesco Rua; Sheila J Sadeghi; Silvia Castrignanò; Giovanna Di Nardo; Gianfranco Gilardi
Engineering Macaca fascicularis cytochrome P450 2C20 to reduce animal testing for new drugs.
Journal of inorganic biochemistry 2012;117():277-84.
2012: Francesco Rua; Sheila J Sadeghi; Giovanna Di Nardo; Gianfranco Gilardi
Toward reduction in animal sacrifice for drugs: Molecular modeling of Macaca fascicularis P450 2C20 for virtual screening of Homo sapiens P450 2C8 substrates.
Biotechnology and applied biochemistry 2012;59(6):479-89.
2012: Daniela Minerdi; Sheila J Sadeghi; Ivan Zgrablic; Gianfranco Gilardi
Identification of a novel Baeyer-Villiger monooxygenase from Acinetobacter radioresistens: close relationship to the Mycobacterium tuberculosis prodrug activator EtaA.
Microbial biotechnology 2012;5(6):700-16.
2012: Sheila J Sadeghi; Giovanna Di Nardo; Silvia Ferrero; Gianfranco Gilardi
Drug-drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4.
Bioelectrochemistry (Amsterdam, Netherlands) 2012;86():87-91.
2012: Valentina E V Ferrero; Gianluca Catucci; Giovanna Di Nardo; Sheila J Sadeghi; Gianfranco Gilardi
Fluorescence detection of ligand binding to labeled cytochrome P450 BM3.
Dalton transactions (Cambridge, England : 2003) 2012;41(7):2018-25.
2012: Gianluca Catucci; Gianfranco Gilardi; Lars Jeuken; Sheila J Sadeghi
In vitro drug metabolism by C-terminally truncated human flavin-containing monooxygenase 3.
Biochemical pharmacology 2012;83(4):551-8.
2011: Simone Morra; Sheila J Sadeghi; Francesca Valetti; Paul W King; Toby Meyer; Gianfranco Gilardi
Direct electrochemistry of an [FeFe]-hydrogenase on a TiO2 electrode.
Chemical communications (Cambridge, England) 2011;47(38):10566-8.
2011: Danilo Degregorio; Sheila J Sadeghi; Giovanna Di Nardo; Gianfranco Gilardi; Sandro P Solinas
Understanding uncoupling in the multiredox centre P450 3A4-BMR model system.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011;16(1):109-16.
2011: Sheila J Sadeghi; Andrea Fantuzzi; Gianfranco Gilardi
Breakthrough in P450 bioelectrochemistry and future perspectives.
Biochimica et biophysica acta 2011;1814(1):237-48.
2010: Andrea Fantuzzi; Ennio Capria; Lok Hang Mak; Vikash R Dodhia; Sheila J Sadeghi; Stephen Collins; Graham Somers; Ejaz Huq; Gianfranco Gilardi
An electrochemical microfluidic platform for human P450 drug metabolism profiling.
Analytical chemistry 2010;82(24):10222-7.
2010: Silvia Castrignanò; Sheila J Sadeghi; Gianfranco Gilardi
Electro-catalysis by immobilised human flavin-containing monooxygenase isoform 3 (hFMO3).
Analytical and bioanalytical chemistry 2010;398(3):1403-9.
2010: Lok Hang Mak; Sheila J Sadeghi; Andrea Fantuzzi; Gianfranco Gilardi
Control of human cytochrome P450 2E1 electrocatalytic response as a result of unique orientation on gold electrodes.
Analytical chemistry 2010;82(12):5357-62.
2009: Andrea Fantuzzi; Yergalem T Meharenna; Paul B Briscoe; Francoise Guerlesquin; Sheila J Sadeghi; Gianfranco Gilardi
Characterisation of the electron transfer and complex formation between flavodoxin from D. vulgaris and the haem domain of cytochrome P450 BM3 from B. megaterium.
Biochimica et biophysica acta 2009;1787(4):234-41.
2009: Andrea Fantuzzi; Roberto Artali; Gabriella Bombieri; Nicoletta Marchini; Fiorella Meneghetti; Gianfranco Gilardi; Sheila J Sadeghi; Davide Cavazzini; Gian Luigi Rossi
Redox properties and crystal structures of a Desulfovibrio vulgaris flavodoxin mutant in the monomeric and homodimeric forms.
Biochimica et biophysica acta 2009;1794(3):496-505.
2004: Kleoniki Gounaris; Murray E Selkirk; Sheila J Sadeghi
A nucleotidase with unique catalytic properties is secreted by Trichinella spiralis.
Molecular and biochemical parasitology 2004;136(2):257-64.
2002: Roberto Artali; Gabriella Bombieri; Fiorella Meneghetti; Gianfranco Gilardi; Sheila J Sadeghi; Davide Cavazzini; Gian Luigi Rossi
Comparison of the refined crystal structures of wild-type (1.34 A) flavodoxin from Desulfovibrio vulgaris and the S35C mutant (1.44 A) at 100 K.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 10 Pt 2):1787-92.
2002: Andrea Fantuzzi; Sheila J Sadeghi; Francesca Valetti; Gian Luigi Rossi; Gianfranco Gilardi
Tuning the reduction potential of engineered cytochrome c-553.
Biochemistry 2002;41(27):8718-24.
2002: Gianfranco Gilardi; Yergalem T Meharenna; Georgia Eleni Tsotsou; Sheila J Sadeghi; Michael Fairhead; Silva Giannini
Molecular Lego: design of molecular assemblies of P450 enzymes for nanobiotechnology.
Biosensors & bioelectronics 2002;17(1-2):133-45.
2001: Gianfranco Gilardi; Andrea Fantuzzi; Sheila J Sadeghi
Engineering and design in the bioelectrochemistry of metalloproteins.
Current opinion in structural biology 2001;11(4):491-9.
2000: Sheila J Sadeghi; Francesca Valetti; C A Cunha; Maria João Romão; C M Soares; Gianfranco Gilardi
Ionic strength dependence of the non-physiological electron transfer between flavodoxin and cytochrome c553 from D vulgaris.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(6):730-7.
2000: Sheila J Sadeghi; Yergalem T Meharenna; Andrea Fantuzzi; Francesca Valetti; Gianfranco Gilardi
Engineering artificial redox chains by molecular 'Lego'.
Faraday discussions 2000;(116):135-53; discussion 171-90.
1999: C A Cunha; Maria João Romão; Sheila J Sadeghi; Francesca Valetti; Gianfranco Gilardi; C M Soares
Effects of protein-protein interactions on electron transfer: docking and electron transfer calculations for complexes between flavodoxin and c-type cytochromes.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 1999;4(3):360-74.
1998: Emmanuel Topoglidis; N Beaumont; Anthony E G Cass; Gianfranco Gilardi; Sheila J Sadeghi; James R Durrant
Protein Adsorption on Nanocrystalline TiO(2) Films: An Immobilization Strategy for Bioanalytical Devices.
Analytical chemistry 1998;70(23):5111-3.
1998: Francesca Valetti; Sheila J Sadeghi; Yergalem T Meharenna; S R Leliveld; Gianfranco Gilardi
Engineering multi-domain redox proteins containing flavodoxin as bio-transformer: preparatory studies by rational design.
Biosensors & bioelectronics 1998;13(6):675-85.
1997: Sheila J Sadeghi; Gianfranco Gilardi; Anthony E G Cass
Mediated electrochemistry of peroxidases--effects of variations in protein and mediator structures.
Biosensors & bioelectronics 1997;12(12):1191-8.
1995: Sheila J Sadeghi; Anthony E G Cass
Electron transfer between cytochrome C peroxidase and ferrocene.
Biochemical Society transactions 1995;23(2):153S.