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Peter Sadler

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Zhe Liu; Mark E Newton; Jennifer S Butler; Robert J Deeth; Abraha Habtemariam; Peter J Sadler
Reduction of quinones by NADH catalyzed by organoiridium complexes.
Jennifer S Butler; Peter J Sadler
Targeted delivery of platinum-based anticancer complexes.
Fuyi Wang; Stefan K Weidt; Kui Wu; Jingjing Xu; Pat R R Langridge-Smith; C Logan Mackay; Peter J Sadler
Competition between glutathione and DNA oligonucleotides for ruthenium(II) arene anticancer complexes.

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All Publications

2013: Zhe Liu; Mark E Newton; Jennifer S Butler; Robert J Deeth; Abraha Habtemariam; Peter J Sadler
Reduction of quinones by NADH catalyzed by organoiridium complexes.
Angewandte Chemie (International ed. in English) 2013;52(15):4194-7.
2013: Jennifer S Butler; Peter J Sadler
Targeted delivery of platinum-based anticancer complexes.
Current opinion in chemical biology 2013;17(2):175-88.
2013: Fuyi Wang; Stefan K Weidt; Kui Wu; Jingjing Xu; Pat R R Langridge-Smith; C Logan Mackay; Peter J Sadler
Competition between glutathione and DNA oligonucleotides for ruthenium(II) arene anticancer complexes.
Dalton transactions (Cambridge, England : 2003) 2013;42(9):3188-95.
2013: Kui Wu; Shaoxiang Xiong; Wenbing Hu; Xianchan Li; Qun Luo; Peter J Sadler; Fuyi Wang
Competitive binding sites of a ruthenium arene anticancer complex on oligonucleotides studied by mass spectrometry: ladder-sequencing versus top-down.
Journal of the American Society for Mass Spectrometry 2013;24(3):410-20.
2013: Nicolas P E Barry; Guy J Clarkson; Robert J Deeth; Ivan Prokes; Peter J Sadler
Thermochromic organometallic complexes: experimental and theoretical studies of 16- to 18-electron interconversions of adducts of arene Ru(II) carboranes with aromatic amine ligands.
Dalton transactions (Cambridge, England : 2003) 2013;42(7):2580-7.
2013: Isolda Romero-Canelón; Luca Salassa; Peter J Sadler
The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes: control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway.
Journal of medicinal chemistry 2013;56(3):1291-300.
2012: Isolda Romero-Canelón; Abraha Habtemariam; Ana M Pizarro; Peter J Sadler
Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes.
Metallomics : integrated biometal science 2012;4(12):1271-9.
2012: Yao Zhao; Vasilios G Stavros; Nicola J Farrer; Simon E Greenough; Martin J Paterson; William H Powell; Gareth M Roberts; Peter J Sadler
Two-photon-activated ligand exchange in platinum(II) complexes.
Angewandte Chemie (International ed. in English) 2012;51(45):11263-6.
2012: Jennifer S Butler; Nicola J Farrer; Mark E Newton; Julie A Woods; Peter J Sadler
Tryptophan switch for a photoactivated platinum anticancer complex.
Journal of the American Chemical Society 2012;134(40):16508-11.
2012: Soledad Betanzos-Lara; Viktor Brabec; Guy J Clarkson; Robert J Deeth; Barbora Liskova; Olga Novakova; Ana M Pizarro; Peter J Sadler; Abraha Habtemariam
Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2012;17(7):1033-51.
2012: Huilin Li; J Emilio Jimenez-Roldan; Rudolf A Römer; Peter J Sadler; Stephen A Wells; Yao Zhao; Peter B O'Connor
Protein flexibility is key to cisplatin crosslinking in calmodulin.
Protein science : a publication of the Protein Society 2012;21(9):1269-79.
2012: Hui-Chung Tai; Yao Zhao; Anna E Anastasi; Guy Clarkson; Nicola J Farrer; Peter J Sadler; Robert J Deeth
A computational approach to tuning the photochemistry of platinum(IV) anticancer agents.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(34):10630-42.
2012: Hui-Chung Tai; Viktor Brabec; Ralf Brodbeck; Nicola J Farrer; Jana Kasparkova; Peter J Sadler; Robert J Deeth
Combined theoretical and computational study of interstrand DNA guanine-guanine cross-linking by trans-[Pt(pyridine)2] derived from the photoactivated prodrug trans,trans,trans-[Pt(N3)2(OH)2(pyridine)2].
Inorganic chemistry 2012;51(12):6830-41.
2012: Allison Ross; Jong-Ha Choi; Erik De Clercq; Tina M Hunter; Stephen A Moggach; Christophe Pannecouque; Simon Parsons; Peter J Sadler
Zinc(II) complexes of constrained antiviral macrocycles.
Dalton transactions (Cambridge, England : 2003) 2012;41(21):6408-18.
2012: Anna Louisa Noffke; Ana M Pizarro; Abraha Habtemariam; Peter J Sadler
Designing organometallic compounds for catalysis and therapy.
Chemical communications (Cambridge, England) 2012;48(43):5219-46.
2012: Jin Lu; Teresa J T Pinheiro; Peter J Sadler; Alan J Stewart; Claudia A Blindauer
Allosteric inhibition of cobalt binding to albumin by fatty acids: implications for the detection of myocardial ischemia.
Journal of medicinal chemistry 2012;55(9):4425-30.
2012: Nicolas P E Barry; Peter J Sadler
Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: biological relevance and synthetic strategies.
Chemical Society reviews 2012;41(8):3264-79.
2012: Soledad Betanzos-Lara; Abraha Habtemariam; Zhe Liu; Ana M Pizarro; Bushra Qamar; Peter J Sadler
Organometallic ruthenium and iridium transfer-hydrogenation catalysts using coenzyme NADH as a cofactor.
Angewandte Chemie (International ed. in English) 2012;51(16):3897-900.
2012: Arindam Mukherjee; Dean Rea; Paul R Bilton; Dominic J Campopiano; Adam Janoschka; Pat R R Langridge-Smith; Logan Mackay; Volker Schünemann; Thomas Teschner; Alfred X Trautwein; Haizhong Zhu; Peter J Sadler
Ferric ion (hydr)oxo clusters in the "Venus flytrap" cleft of FbpA: Mössbauer, calorimetric and mass spectrometric studies.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2012;17(4):573-88.
2012: Claire Booyjzsen; Giovanni Costantini; Ben Moreton; Ian Portman; Charlotte A Scarff; James H Scrivens; Peter J Sadler
Fibrillation of transferrin.
Biochimica et biophysica acta 2012;1820(3):427-36.
2012: Jin Lu; Teresa J T Pinheiro; Peter J Sadler; Darrell Sleep; Alan J Stewart; Claudia A Blindauer
A molecular mechanism for modulating plasma Zn speciation by fatty acids.
Journal of the American Chemical Society 2012;134(3):1454-7.
2011: Ying Fu; Abraha Habtemariam; Aida M B H Basri; Darren Braddick; Guy J Clarkson; Peter J Sadler
Structure-activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity.
Dalton transactions (Cambridge, England : 2003) 2011;40(40):10553-62.
2011: Nicola J Farrer; Peter Gierth; Peter J Sadler
Probing platinum azido complexes by 14N and 15N NMR spectroscopy.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(43):12059-66.
2011: Luca Ronconi; Ruth J McQuitty; Ana M Pizarro; Peter J Sadler
Insights into the acid-base properties of Pt(IV)-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(43):12051-8.
2011: Huilin Li; Tzu-Yung Lin; Hazel I A Phillips; Yulin Qi; Peter J Sadler; Yao Zhao; Peter B O'Connor
Mass spectrometry evidence for cisplatin as a protein cross-linking reagent.
Analytical chemistry 2011;83(13):5369-76.
2011: Zhe Liu; Ana M Pizarro; Guy J Clarkson; Abraha Habtemariam; Luca Salassa; Peter J Sadler
Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes.
Inorganic chemistry 2011;50(12):5777-83.
2011: Anna Kisova; Lenka Zerzankova; Abraha Habtemariam; Peter J Sadler; Viktor Brabec; Jana Kasparkova
Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand.
Molecular pharmaceutics 2011;8(3):949-57.
2011: Jenna Scotcher; David J Clarke; Stefan K Weidt; C Logan Mackay; Ted R Hupp; Peter J Sadler; Pat R R Langridge-Smith
Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry.
Journal of the American Society for Mass Spectrometry 2011;22(5):888-97.
2011: Zhe Liu; Abraha Habtemariam; Ana M Pizarro; Sally A Fletcher; Anna Kisova; Oldrich Vrana; Luca Salassa; Pieter C A Bruijnincx; Guy J Clarkson; Viktor Brabec; Peter J Sadler
Organometallic half-sandwich iridium anticancer complexes.
Journal of medicinal chemistry 2011;54(8):3011-26.
2011: Sabine H van Rijt; Hana Kostrhunova; Viktor Brabec; Peter J Sadler
Functionalization of osmium arene anticancer complexes with (poly)arginine: effect on cellular uptake, internalization, and cytotoxicity.
Bioconjugate chemistry 2011;22(2):218-26.
2011: Luca Ronconi; Peter J Sadler
Photoreaction pathways for the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2].
Dalton transactions (Cambridge, England : 2003) 2011;40(1):262-8.
2010: Ying Fu; Abraha Habtemariam; Ana M Pizarro; Sabine H van Rijt; David J Healey; Patricia A Cooper; Steven D Shnyder; Guy J Clarkson; Peter J Sadler
Organometallic osmium arene complexes with potent cancer cell cytotoxicity.
Journal of medicinal chemistry 2010;53(22):8192-6.
2010: Nicola J Farrer; Julie A Woods; Luca Salassa; Yao Zhao; Kim S Robinson; Guy Clarkson; Fiona S Mackay; Peter J Sadler
A potent trans-diimine platinum anticancer complex photoactivated by visible light.
Angewandte Chemie (International ed. in English) 2010;49(47):8905-8.
2010: Leticia Cubo; Ana M Pizarro; Adoracion Quiroga; Luca Salassa; Carmen Navarro-Ranninger; Peter J Sadler
Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides.
Journal of inorganic biochemistry 2010;104(9):909-18.
2010: Jonathan P Williams; Jeffery M Brown; Iain Campuzano; Peter J Sadler
Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS).
Chemical communications (Cambridge, England) 2010;46(30):5458-60.
2010: Jonathan P Williams; Hazel I A Phillips; Iain Campuzano; Peter J Sadler
Shape changes induced by N-terminal platination of ubiquitin by cisplatin.
Journal of the American Society for Mass Spectrometry 2010;21(7):1097-106.
2010: Olga Novakova; Jaroslav Malina; Tereza Suchankova; Jana Kasparkova; Tijana Bugarcic; Peter J Sadler; Viktor Brabec
Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru(II) complexes containing terphenyl arenes.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(19):5744-54.
2010: Ana M Pizarro; Michael Melchart; Abraha Habtemariam; Luca Salassa; Francesca P A Fabbiani; Simon Parsons; Peter J Sadler
Controlling the reactivity of ruthenium(II) arene complexes by tether ring-opening.
Inorganic chemistry 2010;49(7):3310-9.
2010: Nicola J Farrer; Julie A Woods; Vivienne P Munk; Fiona S Mackay; Peter J Sadler
Photocytotoxic trans-diam(m)ine platinum(IV) diazido complexes more potent than their cis isomers.
Chemical research in toxicology 2010;23(2):413-21.
2010: Allison Ross; Dinesh C Soares; Danielle Covelli; Christophe Pannecouque; Laura Budd; Anna Collins; Neil Robertson; Simon Parsons; Erik De Clercq; Pierre Kennepohl; Peter J Sadler
Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists.
Inorganic chemistry 2010;49(3):1122-32.
2010: Sabine H van Rijt; Arindam Mukherjee; Ana M Pizarro; Peter J Sadler
Cytotoxicity, hydrophobicity, uptake, and distribution of osmium(II) anticancer complexes in ovarian cancer cells.
Journal of medicinal chemistry 2010;53(2):840-9.
2010: Yanbo Shi; Ian Harvey; Dominic Campopiano; Peter J Sadler
Niobium uptake and release by bacterial ferric ion binding protein.
Bioinorganic chemistry and applications 2010;():307578.
2009: Nicola J Farrer; Luca Salassa; Peter J Sadler
Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine.
Dalton transactions (Cambridge, England : 2003) 2009;(48):10690-701.
2009: Sabine H van Rijt; Andrew J Hebden; Thakshila Amaresekera; Robert J Deeth; Guy J Clarkson; Simon Parsons; Patrick C McGowan; Peter J Sadler
Amide linkage isomerism as an activity switch for organometallic osmium and ruthenium anticancer complexes.
Journal of medicinal chemistry 2009;52(23):7753-64.
2009: Sabine H van Rijt; Peter J Sadler
Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs.
Drug discovery today 2009;14(23-24):1089-97.
2009: Luca Salassa; Hazel I A Phillips; Peter J Sadler
Decomposition pathways for the photoactivated anticancer complex cis,trans,cis-[Pt(N3)2(OH)2(NH3)2]: insights from DFT calculations.
Physical chemistry chemical physics : PCCP 2009;11(44):10311-6.
2009: Soledad Betanzos-Lara; Luca Salassa; Abraha Habtemariam; Peter J Sadler
Photocontrolled nucleobase binding to an organometallic Ru(II) arene complex.
Chemical communications (Cambridge, England) 2009;(43):6622-4.
2009: Jonathan P Williams; Julie Ann Lough; Iain Campuzano; Keith Richardson; Peter J Sadler
Use of ion mobility mass spectrometry and a collision cross-section algorithm to study an organometallic ruthenium anticancer complex and its adducts with a DNA oligonucleotide.
Rapid communications in mass spectrometry : RCM 2009;23(22):3563-9.
2009: Alan James Stewart; Claudia A Blindauer; Peter J Sadler
Plasma fatty acid levels may regulate the Zn(2+)-dependent activities of histidine-rich glycoprotein.
Biochimie 2009;91(11-12):1518-22.
2009: Tijana Bugarcic; Abraha Habtemariam; Robert J Deeth; Francesca P A Fabbiani; Simon Parsons; Peter J Sadler
Ruthenium(II) arene anticancer complexes with redox-active diamine ligands.
Inorganic chemistry 2009;48(19):9444-53.
2009: Ana M Pizarro; Peter J Sadler
Unusual DNA binding modes for metal anticancer complexes.
Biochimie 2009;91(10):1198-211.
2009: Thamayanthy Sriskandakumar; Holm Petzold; Pieter C A Bruijnincx; Abraha Habtemariam; Peter J Sadler; Pierre Kennepohl
Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT.
Journal of the American Chemical Society 2009;131(37):13355-61.
2009: Claudia A Blindauer; Ian Harvey; Kerry E Bunyan; Alan James Stewart; Darrell Sleep; David J Harrison; Stephen Berezenko; Peter J Sadler
Structure, properties, and engineering of the major zinc binding site on human albumin.
The Journal of biological chemistry 2009;284(34):23116-24.
2009: Jonathan P Williams; Tijana Bugarcic; Abraha Habtemariam; Kevin Giles; Iain Campuzano; P Mark Rodger; Peter J Sadler
Isomer separation and gas-phase configurations of organoruthenium anticancer complexes: ion mobility mass spectrometry and modeling.
Journal of the American Society for Mass Spectrometry 2009;20(6):1119-22.
2009: Fiona S Mackay; Nicola J Farrer; Luca Salassa; Hui-Chung Tai; Robert J Deeth; Stephen A Moggach; Peter A Wood; Simon Parsons; Peter J Sadler
Synthesis, characterisation and photochemistry of Pt(IV) pyridyl azido acetato complexes.
Dalton transactions (Cambridge, England : 2003) 2009;(13):2315-25.
2009: Luca Salassa; Claudio Garino; Giovanni Salassa; Carlo Nervi; Roberto Gobetto; Carlo Lamberti; Diego Gianolio; Ranieri Bizzarri; Peter J Sadler
Ligand-selective photodissociation from [Ru(bpy)(4AP)4]2+: a spectroscopic and computational study.
Inorganic chemistry 2009;48(4):1469-81.
2009: Sabine H van Rijt; Anna F A Peacock; Russell D L Johnstone; Simon Parsons; Peter J Sadler
Organometallic osmium(II) arene anticancer complexes containing picolinate derivatives.
Inorganic chemistry 2009;48(4):1753-62.
2009: Peter J Sadler
Protein recognition of platinated DNA.
Chembiochem : a European journal of chemical biology 2009;10(1):73-4.
2009: Hazel I A Phillips; Luca Ronconi; Peter J Sadler
Photoinduced reactions of cis,trans,cis-[Pt(IV)(N3)2(OH)2(NH3)2) with 1-methylimidazole.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(7):1588-96.
2008: Tijana Bugarcic; Abraha Habtemariam; Jana Stepankova; Pavla Heringova; Jana Kasparkova; Robert J Deeth; Russell D L Johnstone; Alessandro Prescimone; Andrew Parkin; Simon Parsons; Viktor Brabec; Peter J Sadler
The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes.
Inorganic chemistry 2008;47(24):11470-86.
2008: Jin Lu; Alan James Stewart; Peter J Sadler; Teresa J T Pinheiro; Claudia A Blindauer
Albumin as a zinc carrier: properties of its high-affinity zinc-binding site.
Biochemical Society transactions 2008;36(Pt 6):1317-21.
2008: Anna F A Peacock; Peter J Sadler
Medicinal organometallic chemistry: designing metal arene complexes as anticancer agents.
Chemistry, an Asian journal 2008;3(11):1890-9.
2008: Holm Petzold; Peter J Sadler
Oxidation induced by the antioxidant glutathione (GSH).
Chemical communications (Cambridge, England) 2008;(37):4413-5.
2008: Tijana Bugarcic; Olga Nováková; Anna Halámiková; Lenka Zerzánková; Oldrich Vrána; Jana Kaspárková; Abraha Habtemariam; Simon Parsons; Peter J Sadler; Viktor Brabec
Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes.
Journal of medicinal chemistry 2008;51(17):5310-9.
2008: Jennifer C Gray; Abraha Habtemariam; Marcel Winnig; Wolfgang Meyerhof; Peter J Sadler
Sweetening ruthenium and osmium: organometallic arene complexes containing aspartame.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2008;13(7):1111-20.
2008: Sarah J Dougan; Abraha Habtemariam; Sarah E McHale; Simon Parsons; Peter J Sadler
Catalytic organometallic anticancer complexes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11628-33.
2008: Maria Castellano-Castillo; Hana Kostrhunova; Victoria Marini; Jana Kasparkova; Peter J Sadler; Jean-Marc Malinge; Viktor Brabec
Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2008;13(6):993-9.
2008: Hana Kostrhunova; Jakub Florian; Olga Novakova; Anna F A Peacock; Peter J Sadler; Viktor Brabec
DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media.
Journal of medicinal chemistry 2008;51(12):3635-43.
2008: Fuyi Wang; Stefan Weidt; Jingjing Xu; C Logan Mackay; Pat R R Langridge-Smith; Peter J Sadler
Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass spectrometry combined with (18)O-labeling.
Journal of the American Society for Mass Spectrometry 2008;19(4):544-9.
2008: Luca Ronconi; Peter J Sadler
Unprecedented carbon-carbon bond formation induced by photoactivation of a platinum(IV)-diazido complex.
Chemical communications (Cambridge, England) 2008;(2):235-7.
2008: Holm Petzold; Jingjing Xu; Peter J Sadler
Metal and ligand control of sulfenate reactivity: arene ruthenium thiolato-mono-S-oxides.
Angewandte Chemie (International ed. in English) 2008;47(16):3008-11.
2007: Fiona S Mackay; Julie A Woods; Pavla Heringová; Jana Kaspárková; Ana M Pizarro; Stephen A Moggach; Simon Parsons; Viktor Brabec; Peter J Sadler
A potent cytotoxic photoactivated platinum complex.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20743-8.
2007: James D Hoeschele; Abraha Habtemariam; Jeanette Muir; Peter J Sadler
106Ru radiolabelling of the antitumour complex [(eta6-fluorene)Ru(en)Cl]PF6.
Dalton transactions (Cambridge, England : 2003) 2007;(43):4974-9.
2007: Michael Melchart; Abraha Habtemariam; Simon Parsons; Peter J Sadler
Chlorido-, aqua-, 9-ethylguanine- and 9-ethyladenine-adducts of cytotoxic ruthenium arene complexes containing O,O-chelating ligands.
Journal of inorganic biochemistry 2007;101(11-12):1903-12.
2007: Michael Melchart; Abraha Habtemariam; Olga Novakova; Stephen A Moggach; Francesca P A Fabbiani; Simon Parsons; Viktor Brabec; Peter J Sadler
Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA.
Inorganic chemistry 2007;46(21):8950-62.
2007: Steven W Magennis; Abraha Habtemariam; Olga Novakova; John B Henry; Samuel Meier; Simon Parsons; Iain D H Oswald; Viktor Brabec; Peter J Sadler
Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex.
Inorganic chemistry 2007;46(12):5059-68.
2007: Xiangyang Liang; Dominic J Campopiano; Peter J Sadler
Metals in membranes.
Chemical Society reviews 2007;36(6):968-92.
2007: Anna F A Peacock; Abraha Habtemariam; Stephen A Moggach; Alessandro Prescimone; Simon Parsons; Peter J Sadler
Chloro half-sandwich osmium(II) complexes: influence of chelated N,N-ligands on hydrolysis, guanine binding, and cytotoxicity.
Inorganic chemistry 2007;46(10):4049-59.
2007: Stefan K Weidt; C Logan Mackay; Pat R R Langridge-Smith; Peter J Sadler
Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).
Chemical communications (Cambridge, England) 2007;(17):1719-21.
2007: Anna F A Peacock; Simon Parsons; Peter J Sadler
Tuning the hydrolytic aqueous chemistry of osmium arene complexes with N,O-chelating ligands to achieve cancer cell cytotoxicity.
Journal of the American Chemical Society 2007;129(11):3348-57.
2007: Claudia A Blindauer; M Tahir Razi; Dominic J Campopiano; Peter J Sadler
Histidine ligands in bacterial metallothionein enhance cluster stability.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2007;12(3):393-405.
2007: Hugh P Morgan; Peter Estibeiro; Martin A Wear; Klaas E A Max; Udo Heinemann; Liza Cubeddu; Maurice P Gallagher; Peter J Sadler; Malcolm D Walkinshaw
Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach.
Nucleic acids research 2007;35(10):e75.
2007: Anna F A Peacock; Michael Melchart; Robert J Deeth; Abraha Habtemariam; Simon Parsons; Peter J Sadler
Osmium(II) and ruthenium(II) arene maltolato complexes: rapid hydrolysis and nucleobase binding.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(9):2601-13.
2007: Tina M Hunter; Iain W McNae; Daniel P Simpson; Alison M Smith; Stephen A Moggach; Fraser White; Malcolm D Walkinshaw; Simon Parsons; Peter J Sadler
Configurations of nickel-cyclam antiviral complexes and protein recognition.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(1):40-50.
2006: Pavla Heringova; Julie Woods; Fiona S Mackay; Jana Kasparkova; Peter J Sadler; Viktor Brabec
Transplatin is cytotoxic when photoactivated: enhanced formation of DNA cross-links.
Journal of medicinal chemistry 2006;49(26):7792-8.
2006: Sarah J Dougan; Michael Melchart; Abraha Habtemariam; Simon Parsons; Peter J Sadler
Phenylazo-pyridine and phenylazo-pyrazole chlorido ruthenium(II) arene complexes: arene loss, aquation, and cancer cell cytotoxicity.
Inorganic chemistry 2006;45(26):10882-94.
2006: Hong-Ke Liu; Susan J Berners-Price; Fuyi Wang; John A Parkinson; Jingjing Xu; Juraj Bella; Peter J Sadler
Diversity in guanine-selective DNA binding modes for an organometallic ruthenium arene complex.
Angewandte Chemie (International ed. in English) 2006;45(48):8153-6.
2006: Vivienne P Munk; Sarah Fakih; Piedad Del Socorro Murdoch; Peter J Sadler
Reactions of PtII diamine anticancer complexes with trypanothione and octreotide.
Journal of inorganic biochemistry 2006;100(12):1946-54.
2006: Abraha Habtemariam; Michael Melchart; Rafael Fernandez; Simon Parsons; Iain D H Oswald; Andrew Parkin; Francesca P A Fabbiani; James E Davidson; Alice Dawson; Rhona E Aird; Duncan I Jodrell; Peter J Sadler
Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands.
Journal of medicinal chemistry 2006;49(23):6858-68.
2006: Gina C Valks; Graeme McRobbie; Elizabeth A Lewis; Timothy J Hubin; Tina M Hunter; Peter J Sadler; Christophe Pannecouque; Erik De Clercq; Stephen J Archibald
Configurationally restricted bismacrocyclic CXCR4 receptor antagonists.
Journal of medicinal chemistry 2006;49(21):6162-5.
2006: Hong-Ke Liu; Fuyi Wang; John A Parkinson; Juraj Bella; Peter J Sadler
Ruthenation of duplex and single-stranded d(CGGCCG) by organometallic anticancer complexes.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(23):6151-65.
2006: Jan Paradies; Jane Crudass; Fiona Mackay; Lesley J Yellowlees; James Montgomery; Simon Parsons; Iain D H Oswald; Neil Robertson; Peter J Sadler
Photogeneration of titanium(III) from titanium(IV) citrate in aqueous solution.
Journal of inorganic biochemistry 2006;100(7):1260-4.
2006: Yaw Kai Yan; Michael Melchart; Abraha Habtemariam; Anna F A Peacock; Peter J Sadler
Catalysis of regioselective reduction of NAD+ by ruthenium(II) arene complexes under biologically relevant conditions.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2006;11(4):483-8.
2006: Maolin Guo; Ian Harvey; Dominic J Campopiano; Peter J Sadler
Short oxo-titanium(IV) bond in bacterial transferrin: a protein target for metalloantibiotics.
Angewandte Chemie (International ed. in English) 2006;45(17):2758-61.
2006: Fiona S Mackay; Julie A Woods; Harry Moseley; James Ferguson; Alice Dawson; Simon Parsons; Peter J Sadler
A photoactivated trans-diammine platinum complex as cytotoxic as cisplatin.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(11):3155-61.
2006: Sylvie M Guichard; R Else; E Reid; Benjamin Zeitlin; Rhona E Aird; M Muir; M Dodds; H Fiebig; Peter J Sadler; Duncan I Jodrell
Anti-tumour activity in non-small cell lung cancer models and toxicity profiles for novel ruthenium(II) based organo-metallic compounds.
Biochemical pharmacology 2006;71(4):408-15.
2006: Anna F A Peacock; Abraha Habtemariam; Rafael Fernández; Victoria Walland; Francesca P A Fabbiani; Simon Parsons; Rhona E Aird; Duncan I Jodrell; Peter J Sadler
Tuning the reactivity of osmium(II) and ruthenium(II) arene complexes under physiological conditions.
Journal of the American Chemical Society 2006;128(5):1739-48.
2005: Fuyi Wang; Jingjing Xu; Abraha Habtemariam; Juraj Bella; Peter J Sadler
Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex: detection of a sulfenato intermediate.
Journal of the American Chemical Society 2005;127(50):17734-43.
2005: Fuyi Wang; Abraha Habtemariam; Erwin P L van der Geer; Rafael Fernández; Michael Melchart; Robert J Deeth; Rhona E Aird; Sylvie M Guichard; Francesca P A Fabbiani; Patricia Lozano-Casal; Iain D H Oswald; Duncan I Jodrell; Simon Parsons; Peter J Sadler
Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18269-74.
2005: Geraldine McGowan; Simon Parsons; Peter J Sadler
Contrasting chemistry of cis- and trans-platinum(II) diamine anticancer compounds: hydrolysis studies of picoline complexes.
Inorganic chemistry 2005;44(21):7459-67.
2005: Yaw Kai Yan; Michael Melchart; Abraha Habtemariam; Peter J Sadler
Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes.
Chemical communications (Cambridge, England) 2005;(38):4764-76.
2005: Scott J Roberts; Alan James Stewart; Ralf Schmid; Claudia A Blindauer; Stephanie R Bond; Peter J Sadler; Colin Farquharson
Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2.
Biochimica et biophysica acta 2005;1752(1):73-82.
2005: Geraldine McGowan; Simon Parsons; Peter J Sadler
G-G base-pairing in nucleobase adducts of the anticancer drug cis-[PtCl2(NH3)(2-picoline)] and its trans isomer.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(15):4396-404.
2005: Richard L Hayward; Q C Schornagel; R Tente; Janet S Macpherson; Rhona E Aird; Sylvie M Guichard; Abraha Habtemariam; Peter J Sadler; Duncan I Jodrell
Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organometallic agent, RM175.
Cancer chemotherapy and pharmacology 2005;55(6):577-83.
2005: Fuyi Wang; Juraj Bella; John A Parkinson; Peter J Sadler
Competitive reactions of a ruthenium arene anticancer complex with histidine, cytochrome c and an oligonucleotide.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(2):147-55.
2005: Tina M Hunter; Iain W McNae; Xiangyang Liang; Juraj Bella; Simon Parsons; Malcolm D Walkinshaw; Peter J Sadler
Protein recognition of macrocycles: binding of anti-HIV metallocyclams to lysozyme.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2288-92.
2005: Olga Novakova; Jana Kasparkova; Vendula Bursova; Ctirad Hofr; Marie Vojtiskova; Haimei Chen; Peter J Sadler; Viktor Brabec
Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA binding proteins and repair. Relationship to cytotoxicity.
Chemistry & biology 2005;12(1):121-9.
2005: Alan James Stewart; Claudia A Blindauer; Stephen Berezenko; Darrell Sleep; David Tooth; Peter J Sadler
Role of Tyr84 in controlling the reactivity of Cys34 of human albumin.
The FEBS journal 2005;272(2):353-62.
2005: Claudia A Blindauer; Peter J Sadler
How to hide zinc in a small protein.
Accounts of chemical research 2005;38(1):62-9.
2004: Weiqing Zhong; Dmitriy Alexeev; Ian Harvey; Maolin Guo; Dominic J B Hunter; Haizhong Zhu; Dominic J Campopiano; Peter J Sadler
Assembly of an oxo-zirconium(IV) cluster in a protein cleft.
Angewandte Chemie (International ed. in English) 2004;43(44):5914-8.
2004: Rafael Fernández; Michael Melchart; Abraha Habtemariam; Simon Parsons; Peter J Sadler
Use of chelating ligands to tune the reactive site of half-sandwich ruthenium(II)-arene anticancer complexes.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(20):5173-9.
2004: Vivienne P Munk; Peter J Sadler
Palladium(II) diamine complex induces reduction of glutathione disulfide.
Chemical communications (Cambridge, England) 2004;(16):1788-9.
2004: Iain W McNae; Katy Fishburne; Abraha Habtemariam; Tina M Hunter; Michael Melchart; Fuyi Wang; Malcolm D Walkinshaw; Peter J Sadler
Half-sandwich arene ruthenium(II)-enzyme complex.
Chemical communications (Cambridge, England) 2004;(16):1786-7.
2004: Weiqing Zhong; John A Parkinson; Simon Parsons; Iain D H Oswald; Robert A Coxall; Peter J Sadler
Structure and dynamics of dinuclear zirconium(IV) complexes.
Inorganic chemistry 2004;43(12):3561-72.
2004: Xiangyang Liang; Peter J Sadler
Cyclam complexes and their applications in medicine.
Chemical Society reviews 2004;33(4):246-66.
2004: Tina M Hunter; Stephen J Paisey; Hye-seo Park; Laura Cleghorn; Andrew Parkin; Simon Parsons; Peter J Sadler
Configurations of metallocyclams and relevance to anti-HIV activity.
Journal of inorganic biochemistry 2004;98(5):713-9.
2004: Gilles P M Borrelly; Claudia A Blindauer; Ralf Schmid; Clive S Butler; Chris E Cooper; Ian Harvey; Peter J Sadler; Nigel J Robinson
A novel copper site in a cyanobacterial metallochaperone.
The Biochemical journal 2004;378(Pt 2):293-7.
2004: Stephen J Paisey; Peter J Sadler
Anti-viral cyclam macrocycles : rapid zinc uptake at physiological pH.
Chemical communications (Cambridge, England) 2004;(3):306-7.
2003: Haimei Chen; John A Parkinson; Olga Nováková; Juraj Bella; Fuyi Wang; Alice Dawson; Robert Gould; Simon Parsons; Viktor Brabec; Peter J Sadler
Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14623-8.
2003: Fuyi Wang; Haimei Chen; Simon Parsons; Iain D H Oswald; James E Davidson; Peter J Sadler
Kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and X-ray structures of aqua adducts.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(23):5810-20.
2003: Haizhong Zhu; Dmitriy Alexeev; Dominic J B Hunter; Dominic J Campopiano; Peter J Sadler
Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif.
The Biochemical journal 2003;376(Pt 1):35-41.
2003: Ana María Pizarro; Vivienne P Munk; Carmen Navarro-Ranninger; Peter J Sadler
Hydrolysis triggers oxidation of a trans diamine platinum(II) anticancer complex.
Angewandte Chemie (International ed. in English) 2003;42(43):5339-42.
2003: Olga Novakova; Haimei Chen; Oldrich Vrana; Alison Rodger; Peter J Sadler; Viktor Brabec
DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media.
Biochemistry 2003;42(39):11544-54.
2003: Xiangyang Liang; Michael Weishäupl; John A Parkinson; Simon Parsons; Pamela A McGregor; Peter J Sadler
Selective recognition of configurational substates of zinc cyclam by carboxylates: implications for the design and mechanism of action of anti-HIV agents.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(19):4709-17.
2003: Jana Kaspárková; Fiona S Mackay; Viktor Brabec; Peter J Sadler
Formation of platinated GG cross-links on DNA by photoactivation of a platinum(IV) azide complex.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2003;8(7):741-5.
2003: Dmitriy Alexeev; Haizhong Zhu; Maolin Guo; Weiqing Zhong; Dominic J B Hunter; Weiping Yang; Dominic J Campopiano; Peter J Sadler
A novel protein-mineral interface.
Nature structural biology 2003;10(4):297-302.
2003: Alan James Stewart; Claudia A Blindauer; Stephen Berezenko; Darrell Sleep; Peter J Sadler
Interdomain zinc site on human albumin.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3701-6.
2003: Claudia A Blindauer; Nick C Polfer; Stella E Keiper; Mark D Harrison; Nigel J Robinson; Pat R R Langridge-Smith; Peter J Sadler
Inert site in a protein zinc cluster: isotope exchange by high resolution mass spectrometry.
Journal of the American Chemical Society 2003;125(11):3226-7.
2003: Maolin Guo; Ian Harvey; Weiping Yang; Lorraine S Coghill; Dominic J Campopiano; John A Parkinson; Ross T A MacGillivray; Wesley R Harris; Peter J Sadler
Synergistic anion and metal binding to the ferric ion-binding protein from Neisseria gonorrhoeae.
The Journal of biological chemistry 2003;278(4):2490-502.
2003: Philippe Müller; Björn Schröder; John A Parkinson; Nicole A Kratochwil; Robert A Coxall; Andrew Parkin; Simon Parsons; Peter J Sadler
Nucleotide cross-linking induced by photoreactions of platinum(IV)-azide complexes.
Angewandte Chemie (International ed. in English) 2003;42(3):335-9.
2003: Haimei Chen; John A Parkinson; Robert E Morris; Peter J Sadler
Highly selective binding of organometallic ruthenium ethylenediamine complexes to nucleic acids: novel recognition mechanisms.
Journal of the American Chemical Society 2003;125(1):173-86.
2002: Claudia A Blindauer; Mark D Harrison; Andrea K Robinson; John A Parkinson; Peter W Bowness; Peter J Sadler; Nigel J Robinson
Multiple bacteria encode metallothioneins and SmtA-like zinc fingers.
Molecular microbiology 2002;45(5):1421-32.
2002: Xiangyang Liang; John A Parkinson; Simon Parsons; Michael Weishäupl; Peter J Sadler
Cadmium cyclam complexes: interconversion of cis and trans configurations and fixation of CO(2).
Inorganic chemistry 2002;41(17):4539-47.
2002: Fuyi Wang; Haimei Chen; John A Parkinson; P del S Murdoch; Peter J Sadler
Reactions of a ruthenium(II) arene antitumor complex with cysteine and methionine.
Inorganic chemistry 2002;41(17):4509-23.
2002: Xiangyang Liang; John A Parkinson; Michael Weishäupl; Robert O Gould; Stephen J Paisey; Hye-seo Park; Tina M Hunter; Claudia A Blindauer; Simon Parsons; Peter J Sadler
Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor.
Journal of the American Chemical Society 2002;124(31):9105-12.
2002: Weiqing Zhong; John A Parkinson; Maolin Guo; Peter J Sadler
Unusual features for zirconium(IV) binding to human serum transferrin.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(6):589-99.
2002: Rhona E Aird; Jeff Cummings; AA Ritchie; M Muir; Robert E Morris; Haimei Chen; Peter J Sadler; Duncan I Jodrell
In vitro and in vivo activity and cross resistance profiles of novel ruthenium (II) organometallic arene complexes in human ovarian cancer.
British journal of cancer 2002;86(10):1652-7.
2002: Haimei Chen; John A Parkinson; Simon Parsons; Robert A Coxall; Robert O Gould; Peter J Sadler
Organometallic ruthenium(II) diamine anticancer complexes: arene-nucleobase stacking and stereospecific hydrogen-bonding in guanine adducts.
Journal of the American Chemical Society 2002;124(12):3064-82.
2002: Emma J Beatty; Weiqing Zhong; Gina Kubal; David Houldershaw; Julia M Goodfellow; Peter J Sadler
Histidine pK(a) values for the N-lobe of human transferrin: effect of substitution of binding site Asp by Ser (D63S).
Journal of inorganic biochemistry 2002;88(3-4):403-9.
2002: Milos I Djuran; Snezana U Milinkovic; Abraha Habtemariam; Simon Parsons; Peter J Sadler
Crystal packing and hydrogen bonding in platinum(II) nucleotide complexes: X-ray crystal structure of [Pt(MeSCH(2)CH(2)SMe)(5'-GMP-N7)(2)].6H(2)O.
Journal of inorganic biochemistry 2002;88(3-4):268-73.
2001: Robert E Morris; Rhona E Aird; P del S Murdoch; Haimei Chen; Jeff Cummings; N D Hughes; Simon Parsons; Andrew Parkin; G Boyd; Duncan I Jodrell; Peter J Sadler
Inhibition of cancer cell growth by ruthenium(II) arene complexes.
Journal of medicinal chemistry 2001;44(22):3616-21.
2001: Maolin Guo; Z Guo; Peter J Sadler
Titanium(IV) targets phosphoesters on nucleotides: implications for the mechanism of action of the anticancer drug titanocene dichloride.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(7):698-707.
2001: Claudia A Blindauer; Mark D Harrison; John A Parkinson; Andrea K Robinson; Jennifer S Cavet; Nigel J Robinson; Peter J Sadler
A metallothionein containing a zinc finger within a four-metal cluster protects a bacterium from zinc toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9593-8.
2001: H Sun; H Li; Anne Mason; Robert C Woodworth; Peter J Sadler
Competitive binding of bismuth to transferrin and albumin in aqueous solution and in blood plasma.
The Journal of biological chemistry 2001;276(12):8829-35.
2000: John A Parkinson; Y Chen; P del Socorro Murdoch; Z Guo; Susan J Berners-Price; T Brown; Peter J Sadler
Sequence-dependent bending of DNA induced by cisplatin: NMR structures of an A.T-rich 14-mer duplex.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(19):3636-44.
2000: M Guo; H Sun; Harry J McArdle; Lorraine Gambling; Peter J Sadler
Ti(IV) uptake and release by human serum transferrin and recognition of Ti(IV)-transferrin by cancer cells: understanding the mechanism of action of the anticancer drug titanocene dichloride.
Biochemistry 2000;39(33):10023-33.
2000: M Guo; H Sun; S Bihari; John A Parkinson; Robert O Gould; Simon Parsons; Peter J Sadler
Stereoselective formation of seven-coordinate titanium(IV) monomer and dimer complexes of ethylenebis(o-hydroxyphenyl)glycine.
Inorganic chemistry 2000;39(2):206-15.
1999: H Sun; H Li; Ian Harvey; Peter J Sadler
Interactions of bismuth complexes with metallothionein(II).
The Journal of biological chemistry 1999;274(41):29094-101.
1999: M C Cox; Kevin J Barnham; T A Frenkiel; J D Hoeschele; Anne Mason; Qing-Yu He; Robert C Woodworth; Peter J Sadler
Identification of platination sites on human serum transferrin using (13)C and (15)N NMR spectroscopy.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 1999;4(5):621-31.
1999: Kamila Neplechová; Jana Kaspárková; Oldrich Vrána; Olga Nováková; Abraha Habtemariam; B Watchman; Peter J Sadler; Viktor Brabec
DNA interactions of new antitumor aminophosphine platinum(II) complexes.
Molecular pharmacology 1999;56(1):20-30.
1999: P del S Murdoch; Z Guo; John A Parkinson; Peter J Sadler
Kinetics of formation and stability of [Pt(dien)]2+ complexes with octamer and 14-mer DNA oligonucleotides containing a GG sequence.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 1999;4(1):32-8.
1999: Sabine Best; Z Guo; M I Djuran; Peter J Sadler
[AU(DIEN)Cl]Cl(2): Exchange Phenomena Observed by H and C NMR Spectroscopy.
Metal-based drugs 1999;6(4-5):261-9.
1999: H Sun; H Li; Anne Mason; Robert C Woodworth; Peter J Sadler
N-lobe versus C-lobe complexation of bismuth by human transferrin.
The Biochemical journal 1999;337 ( Pt 1)():105-11.
1998: A I Ivanov; J Christodoulou; John A Parkinson; Kevin J Barnham; A Tucker; J Woodrow; Peter J Sadler
Cisplatin binding sites on human albumin.
The Journal of biological chemistry 1998;273(24):14721-30.
1998: H Sun; M C Cox; H Li; Anne Mason; Robert C Woodworth; Peter J Sadler
[1H,13C] NMR determination of the order of lobe loading of human transferrin with iron: comparison with other metal ions.
FEBS letters 1998;422(3):315-20.
1997: F Reeder; Z Guo; P D Murdoch; A Corazza; Trevor W Hambley; Susan J Berners-Price; Jean-Claude Chottard; Peter J Sadler
Platination of a GG site on single-stranded and double-stranded forms of a 14-base oligonucleotide with diaqua cisplatin followed by NMR and HPLC -- influence of the platinum ligands and base sequence on 5'-G versus 3'-G platination selectivity.
European journal of biochemistry / FEBS 1997;249(2):370-82.
1997: Susan J Berners-Price; A Corazza; Z Guo; Kevin J Barnham; Peter J Sadler; Y Ohyama; M Leng; D Locker
Structural transitions of a GG-platinated DNA duplex induced by pH, temperature and box A of high-mobility-group protein 1.
European journal of biochemistry / FEBS 1997;243(3):782-91.
1997: Peter J Sadler
Workshop on: Chemistry of Metals in Medicine - The Industrial Perspective.
Metal-based drugs 1997;4(3):119-23.
1996: H Li; Peter J Sadler; H Sun
Rationalization of the strength of metal binding to human serum transferrin.
European journal of biochemistry / FEBS 1996;242(2):387-93.
1996: J H Viles; John Mitchell; S L Gough; P M Doyle; C J Harris; Peter J Sadler; Janet M Thornton
Multiple solution conformations of the integrin-binding cyclic pentapeptide cyclo(-Ser-D-Leu-Asp-Val-Pro-). Analysis of the (phi, psi) space available to cyclic pentapeptides.
European journal of biochemistry / FEBS 1996;242(2):352-62.
1996: R Harris; S U Patel; Peter J Sadler; J H Viles
Observation of albumin resonances in proton nuclear magnetic resonance spectra of human blood plasma: N-terminal assignments aided by use of modified recombinant albumin.
The Analyst 1996;121(7):913-22.
1996: E J Beatty; M C Cox; T A Frenkiel; BM Tam; Anne Mason; Ross T A MacGillivray; Peter J Sadler; Robert C Woodworth
Interlobe communication in 13C-methionine-labeled human transferrin.
Biochemistry 1996;35(24):7635-42.
1996: H Li; Peter J Sadler; H Sun
Unexpectedly strong binding of a large metal ion (Bi3+) to human serum transferrin.
The Journal of biological chemistry 1996;271(16):9483-9.
1996: D T Jones; C M Moody; J Uppenbrink; J H Viles; P M Doyle; C J Harris; Laurence H Pearl; Peter J Sadler; Janet M Thornton
Towards meeting the Paracelsus Challenge: The design, synthesis, and characterization of paracelsin-43, an alpha-helical protein with over 50% sequence identity to an all-beta protein.
Proteins 1996;24(4):502-13.
1996: A Corazza; I Harvey; Peter J Sadler
1H,13C-NMR and X-ray absorption studies of copper(I) glutathione complexes.
European journal of biochemistry / FEBS 1996;236(2):697-705.
1995: J Christodoulou; Peter J Sadler; A Tucker
1H NMR of albumin in human blood plasma: drug binding and redox reactions at Cys34.
FEBS letters 1995;376(1-2):1-5.
1995: G Kubal; D J Meyer; R E Norman; Peter J Sadler
Investigations of glutathione conjugation in vitro by 1H NMR spectroscopy. Uncatalyzed and glutathione transferase-catalyzed reactions.
Chemical research in toxicology 1995;8(5):780-91.
1994: J Christodoulou; Peter J Sadler; A Tucker
A new structural transition of serum albumin dependent on the state of Cys34. Detection by 1H-NMR spectroscopy.
European journal of biochemistry / FEBS 1994;225(1):363-8.
1994: G Kubal; Peter J Sadler; A Tucker
pH-induced structural changes in human serum apotransferrin. pKa values of histidine residues and N-terminal amino group determined by 1H-NMR spectroscopy.
European journal of biochemistry / FEBS 1994;220(3):781-7.
1994: Peter J Sadler; A Tucker; J H Viles
Involvement of a lysine residue in the N-terminal Ni2+ and Cu2+ binding site of serum albumins. Comparison with Co2+, Cd2+ and Al3+.
European journal of biochemistry / FEBS 1994;220(1):193-200.
1993: G Kubal; Anne Mason; S U Patel; Peter J Sadler; Robert C Woodworth
Oxalate- and Ga(3+)-induced structural changes in human serum transferrin and its recombinant N-lobe. 1H NMR detection of preferential C-lobe Ga3+ binding.
Biochemistry 1993;32(13):3387-95.
1993: Peter J Sadler; A Tucker
pH-induced structural transitions of bovine serum albumin. Histidine pKa values and unfolding of the N-terminus during the N to F transition.
European journal of biochemistry / FEBS 1993;212(3):811-7.
1993: Jimmy D Bell; G Kubal; S Radulovic; Peter J Sadler; A Tucker
Detection of aluminium(III) binding to citrate in human blood plasma by proton nuclear magnetic resonance spectroscopy.
The Analyst 1993;118(3):241-4.
1993: J K Lodge; S U Patel; Peter J Sadler
Aldehydes from metal ion- and lipoxygenase-induced lipid peroxidation: detection by 1H-n.m.r. spectroscopy.
The Biochemical journal 1993;289 ( Pt 1)():149-53.
1992: G Kubal; Anne Mason; Peter J Sadler; A Tucker; Robert C Woodworth
Uptake of Al3+ into the N-lobe of human serum transferrin.
The Biochemical journal 1992;285 ( Pt 3)():711-4.
1992: M D Rhodes; Peter J Sadler; M D Scawen; S Silver
Effects of gold(I) antiarthritic drugs and related compounds on Pseudomonas putida.
Journal of inorganic biochemistry 1992;46(2):129-42.
1992: Peter J Sadler; A Tucker
Proton NMR studies of bovine serum albumin. Assignment of spin systems.
European journal of biochemistry / FEBS 1992;205(2):631-43.
1992: S W Bligh; H A Boyle; A B McEwen; Peter J Sadler; R H Woodham
1H NMR studies of reactions of copper complexes with human blood plasma and urine.
Biochemical pharmacology 1992;43(2):137-45.
1991: Jimmy D Bell; Peter J Sadler; V C Morris; O A Levander
Effect of aging and diet on proton NMR spectra of rat urine.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1991;17(2):414-22.
1991: S W Bligh; C T Harding; Peter J Sadler; R A Bulman; G M Bydder; J M Pennock; J D Kelly; I A Latham; J A Marriott
Use of paramagnetic chelated metal derivatives of polysaccharides and spin-labeled polysaccharides as contrast agents in magnetic resonance imaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1991;17(2):516-32.
1990: S W Bligh; A F Drake; Peter J Sadler
Nuclear magnetic resonance and circular dichroism spectroscopic studies of copper complexation in blood plasma.
Biochemical Society transactions 1990;18(5):999-1000.
1990: Peter J Sadler; A Tucker
1H n.m.r. studies of serum albumin: assignment of resonances for N-terminal amino acids.
Biochemical Society transactions 1990;18(5):923-4.
1990: Susan J Berners-Price; G R Girard; D T Hill; B M Sutton; P S Jarrett; L F Faucette; Randall K Johnson; C K Mirabelli; Peter J Sadler
Cytotoxicity and antitumor activity of some tetrahedral bis(diphosphino)gold(I) chelates.
Journal of medicinal chemistry 1990;33(5):1386-92.
1989: Jimmy D Bell; J C Brown; Peter J Sadler
NMR studies of body fluids.
NMR in biomedicine 1989;2(5-6):246-56.
1989: Jeremy K Nicholson; D P Higham; John A Timbrell; Peter J Sadler
Quantitative high resolution 1H NMR urinalysis studies on the biochemical effects of cadmium in the rat.
Molecular pharmacology 1989;36(3):398-404.
1989: J C Brown; Graham A Mills; Peter J Sadler; V Walker
1H NMR studies of urine from premature and sick babies.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1989;11(2):193-201.
1989: Jimmy D Bell; J C Brown; Peter J Sadler; D Garvie; A F Macleod; Clara Lowy
Maternal and cord blood plasma. Comparative analyses by 1H NMR spectroscopy.
NMR in biomedicine 1989;2(2):61-5.
1989: S W Bligh; A F Drake; Peter J Sadler
Ultraviolet and magnetic-circular-dichroic spectroscopic studies of Gd(III) complexed with diethylenetriaminepentaacetic acid. A contrast agent for NMR imaging.
European journal of biochemistry / FEBS 1989;181(1):223-4.
1989: S W Bligh; Peter J Sadler; J A Marriott; I A Latham; J D Kelly
Characterization and in vivo distribution of 99mTc- and 111In-labelled magnetite.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1989;40(9):751-7.
1989: M H Rayner; Martin Grootveld; Peter J Sadler
Molecular distribution of gold(I) in human blood plasma after treatment with the antiarthritic disodium aurothiomalate.
International journal of clinical pharmacology research 1989;9(6):377-83.
1988: Jimmy D Bell; J C Brown; G Kubal; Peter J Sadler
NMR-invisible lactate in blood plasma.
FEBS letters 1988;235(1-2):81-6.
1988: Susan J Berners-Price; Randall K Johnson; A J Giovenella; L F Faucette; C K Mirabelli; Peter J Sadler
Antimicrobial and anticancer activity of tetrahedral, chelated, diphosphine silver(I) complexes: comparison with copper and gold.
Journal of inorganic biochemistry 1988;33(4):285-95.
1988: Jimmy D Bell; J C Brown; R E Norman; Peter J Sadler; D R Newell
Factors affecting 1H NMR spectra of blood plasma: cancer, diet and freezing.
NMR in biomedicine 1988;1(2):90-4.
1988: J R Bales; Jimmy D Bell; Jeremy K Nicholson; Peter J Sadler; J A Timbrell; R D Hughes; P N Bennett; R Williams
Metabolic profiling of body fluids by proton NMR: self-poisoning episodes with paracetamol (acetaminophen).
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1988;6(3):300-6.
1987: Susan J Berners-Price; Peter J Sadler
Interaction of the antitumor Au(I) complex [Au(Ph2P(CH2)2PPh2)2]Cl with human blood plasma, red cells, and lipoproteins: 31P and 1H NMR studies.
Journal of inorganic biochemistry 1987;31(4):267-81.
1987: Jimmy D Bell; R E Norman; Peter J Sadler
Coordination chemistry in biological media: reactions of antitumor Pt(II) and Au(III) complexes with cell culture media.
Journal of inorganic biochemistry 1987;31(4):241-6.
1987: Susan J Berners-Price; R E Norman; Peter J Sadler
The autoxidation and proton dissociation constants of tertiary diphosphines: relevance to biological activity.
Journal of inorganic biochemistry 1987;31(3):197-209.
1987: J K Nicholson; Peter J Sadler; M Vasák
Probing the reactivity of the zinc and cadmium ions bound to rabbit liver metallothioneins with EDTA.
Experientia. Supplementum 1987;52():191-201.
1986: J R Bales; Jimmy D Bell; Jeremy K Nicholson; Peter J Sadler
1H NMR studies of urine during fasting: excretion of ketone bodies and acetylcarnitine.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1986;3(6):849-56.
1986: Susan J Berners-Price; C K Mirabelli; Randall K Johnson; Michael R Mattern; F L McCabe; L F Faucette; C M Sung; S M Mong; Peter J Sadler; S T Crooke
In vivo antitumor activity and in vitro cytotoxic properties of bis[1,2-bis(diphenylphosphino)ethane]gold(I) chloride.
Cancer research 1986;46(11):5486-93.
1986: D P Higham; Peter J Sadler; M D Scawen
Gold-resistant bacteria: excretion of a cystine-rich protein by Pseudomonas cepacia induced by an antiarthritic drug.
Journal of inorganic biochemistry 1986;28(2-3):253-61.
1986: J C Brown; Peter J Sadler; D J Spalton; S M Juul; A F Macleod; Peter H Sönksen
Analysis of human aqueous humour by high resolution 1H NMR spectroscopy.
Experimental eye research 1986;42(4):357-62.
1986: D P Higham; Peter J Sadler; M D Scawen
Cadmium-binding proteins in Pseudomonas putida: pseudothioneins.
Environmental health perspectives 1986;65():5-11.
1986: D P Higham; J K Nicholson; J Overnell; Peter J Sadler
NMR studies of crab and plaice metallothioneins.
Environmental health perspectives 1986;65():157-65.
1985: G G Graham; J R Bales; M C Grootveld; Peter J Sadler
1H, 13C NMR, and electronic absorption spectroscopic studies of the interaction of cyanide with aurothiomalate.
Journal of inorganic biochemistry 1985;25(3):163-73.
1985: Jeremy K Nicholson; J A Timbrell; J R Bales; Peter J Sadler
A high resolution proton nuclear magnetic resonance approach to the study of hepatocyte and drug metabolism. Application to acetaminophen.
Molecular pharmacology 1985;27(6):634-43.
1985: J R Bales; Jeremy K Nicholson; Peter J Sadler
Two-dimensional proton nuclear magnetic resonance "maps" of acetaminophen metabolites in human urine.
Clinical chemistry 1985;31(5):757-62.
1984: J R Bales; Peter J Sadler; Jeremy K Nicholson; J A Timbrell
Urinary excretion of acetaminophen and its metabolites as studied by proton NMR spectroscopy.
Clinical chemistry 1984;30(10):1631-6.
1984: J R Bales; D P Higham; I Howe; Jeremy K Nicholson; Peter J Sadler
Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine.
Clinical chemistry 1984;30(3):426-32.
1984: J K Nicholson; M P O'Flynn; Peter J Sadler; A F Macleod; S M Juul; P H Sönksen
Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects.
The Biochemical journal 1984;217(2):365-75.
1982: J R Bales; Peter J Sadler; C J Coulson; M Laverick; A H Nias
Hypoxic cell sensitization to radiation damage by a new radiosensitizer: cis-dichloro-bis(1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole-N3)platinum(II) (flap).
British journal of cancer 1982;46(5):701-5.