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Paul Sadowski

Research Profile

Chemicals & Drugs

Living Beings

Saccharomyces cerevisiae

Concepts & Ideas

Physiology

Disorders

Beckwith-Wiedemann Syndrome

Anatomy

Chromosomes, Human, Pair 11

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Publications

TOP 3
Lia Cardarelli; Robert Lam; Ashleigh Tuite; Lindsay A Baker; Paul D Sadowski; Devon R Radford; John L Rubinstein; Kevin P Battaile; Nickolay Chirgadze; Karen L Maxwell; Alan R Davidson
The crystal structure of bacteriophage HK97 gp6: defining a large family of head-tail connector proteins.
Melissa J MacPherson; Paul D Sadowski
The CTCF insulator protein forms an unusual DNA structure.
Melissa J MacPherson; Linda G Beatty; Wenjing Zhou; Minjie Du; Paul D Sadowski
The CTCF insulator protein is posttranslationally modified by SUMO.

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All Publications

2010: Lia Cardarelli; Robert Lam; Ashleigh Tuite; Lindsay A Baker; Paul D Sadowski; Devon R Radford; John L Rubinstein; Kevin P Battaile; Nickolay Chirgadze; Karen L Maxwell; Alan R Davidson
The crystal structure of bacteriophage HK97 gp6: defining a large family of head-tail connector proteins.
Journal of molecular biology 2010;395(4):754-68.
2010: Melissa J MacPherson; Paul D Sadowski
The CTCF insulator protein forms an unusual DNA structure.
BMC molecular biology 2010;11():101.
2009: Melissa J MacPherson; Linda G Beatty; Wenjing Zhou; Minjie Du; Paul D Sadowski
The CTCF insulator protein is posttranslationally modified by SUMO.
Molecular and cellular biology 2009;29(3):714-25.
2006: Cheryl Shuman; Adam Smith; Leslie Steele; Peter N Ray; Carol L Clericuzio; Elaine Zackai; Melissa A Parisi; Anna T Meadows; Thaddeus Kelly; David Tichauer; Jeremy A Squire; Paul D Sadowski; Rosanna Weksberg
Constitutional UPD for chromosome 11p15 in individuals with isolated hemihyperplasia is associated with high tumor risk and occurs following assisted reproductive technologies.
American journal of medical genetics. Part A 2006;140(14):1497-503.
2006: Linda G Beatty; Rosanna Weksberg; Paul D Sadowski
Detailed analysis of the methylation patterns of the KvDMR1 imprinting control region of human chromosome 11.
Genomics 2006;87(1):46-56.
2004: Minjie Du; Wenjing Zhou; Linda G Beatty; Rosanna Weksberg; Paul D Sadowski
The KCNQ1OT1 promoter, a key regulator of genomic imprinting in human chromosome 11p15.5.
Genomics 2004;84(2):288-300.
2004: Jocelyne M Lew; Yan-Ling Fei; Kirk Aleck; Benjamin J Blencowe; Rosanna Weksberg; Paul D Sadowski
CDKN1C mutation in Wiedemann-Beckwith syndrome patients reduces RNA splicing efficiency and identifies a splicing enhancer.
American journal of medical genetics. Part A 2004;127A(3):268-76.
2003: Linda Lee; Paul D Sadowski
Identification of Cre residues involved in synapsis, isomerization, and catalysis.
The Journal of biological chemistry 2003;278(38):36905-15.
2003: Minjie Du; Linda G Beatty; Wenjing Zhou; Jocelyne M Lew; Christopher Schoenherr; Rosanna Weksberg; Paul D Sadowski
Insulator and silencer sequences in the imprinted region of human chromosome 11p15.5.
Human molecular genetics 2003;12(15):1927-39.
2003: Paul D Sadowski
The Flp double cross system a simple efficient procedure for cloning DNA fragments.
BMC biotechnology 2003;3():9.
2003: Linda Lee; Linda C H Chu; Paul D Sadowski
Cre induces an asymmetric DNA bend in its target loxP site.
The Journal of biological chemistry 2003;278(25):23118-29.
2003: Rosanna Weksberg; Adam Smith; Jeremy Squire; Paul D Sadowski
Beckwith-Wiedemann syndrome demonstrates a role for epigenetic control of normal development.
Human molecular genetics 2003;12 Spec No 1():R61-8.
2003: Linda Lee; Paul D Sadowski
Sequence of the loxP site determines the order of strand exchange by the Cre recombinase.
Journal of molecular biology 2003;326(2):397-412.
2002: Michael Goldman; Adam Smith; Cheryl Shuman; Oana Caluseriu; Chihong Wei; Leslie Steele; Peter Ray; Paul D Sadowski; Jeremy Squire; Rosanna Weksberg; Norman D Rosenblum
Renal abnormalities in beckwith-wiedemann syndrome are associated with 11p15.5 uniparental disomy.
Journal of the American Society of Nephrology : JASN 2002;13(8):2077-84.
2002: Rosanna Weksberg; Cheryl Shuman; Oana Caluseriu; Adam Smith; Yan-Ling Fei; Joy Nishikawa; Tracy L Stockley; Lyle Best; David Chitayat; Ann Olney; Elizabeth Ives; Adele Schneider; Timothy H Bestor; Madeline Li; Paul D Sadowski; Jeremy Squire
Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome.
Human molecular genetics 2002;11(11):1317-25.
2001: Rosanna Weksberg; Joy Nishikawa; Oana Caluseriu; Yan-Ling Fei; Cheryl Shuman; C Wei; Leslie Steele; J Cameron; Adam Smith; I Ambus; Madeline Li; Peter N Ray; Paul D Sadowski; Jeremy Squire
Tumor development in the Beckwith-Wiedemann syndrome is associated with a variety of constitutional molecular 11p15 alterations including imprinting defects of KCNQ1OT1.
Human molecular genetics 2001;10(26):2989-3000.
2001: Linda Lee; Paul D Sadowski
Directional resolution of synthetic holliday structures by the Cre recombinase.
The Journal of biological chemistry 2001;276(33):31092-8.
2000: AC Shaikh; Paul D Sadowski
Trans complementation of variant Cre proteins for defects in cleavage and synapsis.
The Journal of biological chemistry 2000;275(39):30186-95.
2000: AC Shaikh; Paul D Sadowski
Chimeras of the Flp and Cre recombinases: tests of the mode of cleavage by Flp and Cre.
Journal of molecular biology 2000;302(1):27-48.
1998: KH Luetke; Paul D Sadowski
DNA sequence determinant for FIp-induced DNA bending.
Molecular microbiology 1998;29(1):199-208.
1998: KH Luetke; Paul D Sadowski
Determinants of the position of a Flp-induced DNA bend.
Nucleic acids research 1998;26(6):1401-7.
1998: X D Zhu; Paul D Sadowski
Selection of novel, specific single-stranded DNA sequences by Flp, a duplex-specific DNA binding protein.
Nucleic acids research 1998;26(5):1329-36.
1998: X D Zhu; Paul D Sadowski
The role of single-stranded DNA in Flp-mediated strand exchange.
The Journal of biological chemistry 1998;273(9):4921-7.
1997: KH Luetke; B P Zhao; Paul D Sadowski
Asymmetry in Flp-mediated cleavage.
Nucleic acids research 1997;25(21):4240-9.
1997: N Azam; J E Dixon; Paul D Sadowski
Topological analysis of the role of homology in Flp-mediated recombination.
The Journal of biological chemistry 1997;272(13):8731-8.
1997: AC Shaikh; Paul D Sadowski
The Cre recombinase cleaves the lox site in trans.
The Journal of biological chemistry 1997;272(9):5695-702.
1995: J E Dixon; A C Shaikh; Paul D Sadowski
The Flp recombinase cleaves Holliday junctions in trans.
Molecular microbiology 1995;18(3):449-58.
1995: X D Zhu; Paul D Sadowski
Cleavage-dependent ligation by the FLP recombinase. Characterization of a mutant FLP protein with an alteration in a catalytic amino acid.
The Journal of biological chemistry 1995;270(39):23044-54.
1995: K H Luetke; Paul D Sadowski
The role of DNA bending in Flp-mediated site-specific recombination.
Journal of molecular biology 1995;251(4):493-506.
1995: L D McBroom; Paul D Sadowski
Functional analysis of the ABF1-binding sites within the Ya regions of the MATa and HMRa loci of Saccharomyces cerevisiae.
Current genetics 1995;28(1):1-11.
1995: X D Zhu; G Pan; K Luetke; Paul D Sadowski
Homology requirements for ligation and strand exchange by the FLP recombinase.
The Journal of biological chemistry 1995;270(19):11646-53.
1995: Paul D Sadowski
The Flp recombinase of the 2-microns plasmid of Saccharomyces cerevisiae.
Progress in nucleic acid research and molecular biology 1995;51():53-91.
1994: J E Dixon; Paul D Sadowski
Resolution of immobile chi structures by the FLP recombinase of 2 microns plasmid.
Journal of molecular biology 1994;243(2):199-207.
1994: L D McBroom; Paul D Sadowski
DNA bending by Saccharomyces cerevisiae ABF1 and its proteolytic fragments.
The Journal of biological chemistry 1994;269(23):16461-8.
1994: L D McBroom; Paul D Sadowski
Contacts of the ABF1 protein of Saccharomyces cerevisiae with a DNA binding site at MATa.
The Journal of biological chemistry 1994;269(23):16455-60.
1994: G B Panigrahi; Paul D Sadowski
Interaction of the NH2- and COOH-terminal domains of the FLP recombinase with the FLP recognition target sequence.
The Journal of biological chemistry 1994;269(14):10940-5.
1993: J E Dixon; Paul D Sadowski
Resolution of synthetic chi structures by the FLP site-specific recombinase.
Journal of molecular biology 1993;234(3):522-33.
1993: G Pan; Paul D Sadowski
Identification of the functional domains of the FLP recombinase. Separation of the nonspecific and specific DNA-binding, cleavage, and ligation domains.
The Journal of biological chemistry 1993;268(30):22546-51.
1993: G Pan; K Luetke; Paul D Sadowski
Mechanism of cleavage and ligation by FLP recombinase: classification of mutations in FLP protein by in vitro complementation analysis.
Molecular and cellular biology 1993;13(6):3167-75.
1993: Paul D Sadowski
Site-specific genetic recombination: hops, flips, and flops.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(9):760-7.
1993: G Pan; K Luetke; C D Juby; R Brousseau; Paul D Sadowski
Ligation of synthetic activated DNA substrates by site-specific recombinases and topoisomerase I.
The Journal of biological chemistry 1993;268(5):3683-9.
1993: J Kulpa; J E Dixon; G Pan; Paul D Sadowski
Mutations of the FLP recombinase gene that cause a deficiency in DNA bending and strand cleavage.
The Journal of biological chemistry 1993;268(2):1101-8.
1992: G B Panigrahi; L G Beatty; Paul D Sadowski
The FLP protein contacts both major and minor grooves of its recognition target sequence.
Nucleic acids research 1992;20(22):5927-35.
1992: G Pan; Paul D Sadowski
Ligation activity of FLP recombinase. The strand ligation activity of a site-specific recombinase using an activated DNA substrate.
The Journal of biological chemistry 1992;267(18):12397-9.
1992: H Friesen; Paul D Sadowski
Mutagenesis of a conserved region of the gene encoding the FLP recombinase of Saccharomyces cerevisiae. A role for arginine 191 in binding and ligation.
Journal of molecular biology 1992;225(2):313-26.
1991: A Amin; H Roca; K Luetke; Paul D Sadowski
Synapsis, strand scission, and strand exchange induced by the FLP recombinase: analysis with half-FRT sites.
Molecular and cellular biology 1991;11(9):4497-508.
1991: H Pan; D Clary; Paul D Sadowski
Identification of the DNA-binding domain of the FLP recombinase.
The Journal of biological chemistry 1991;266(17):11347-54.
1990: C J Schwartz; Paul D Sadowski
FLP protein of 2 mu circle plasmid of yeast induces multiple bends in the FLP recognition target site.
Journal of molecular biology 1990;216(2):289-98.
1990: A A Amin; L G Beatty; Paul D Sadowski
Synaptic intermediates promoted by the FLP recombinase.
Journal of molecular biology 1990;214(1):55-72.
1989: A A Amin; Paul D Sadowski
Synthesis of an enzymatically active FLP recombinase in vitro: search for a DNA-binding domain.
Molecular and cellular biology 1989;9(5):1987-95.
1989: C J Schwartz; Paul D Sadowski
FLP recombinase of the 2 microns circle plasmid of Saccharomyces cerevisiae bends its DNA target. Isolation of FLP mutants defective in DNA bending.
Journal of molecular biology 1989;205(4):647-58.
1988: L G Beatty; Paul D Sadowski
The mechanism of loading of the FLP recombinase onto its DNA target sequence.
Journal of molecular biology 1988;204(2):283-94.
1987: B J Andrews; L G Beatty; Paul D Sadowski
Isolation of intermediates in the binding of the FLP recombinase of the yeast plasmid 2-micron circle to its target sequence.
Journal of molecular biology 1987;193(2):345-58.
1986: G Proteau; D Sidenberg; Paul D Sadowski
The minimal duplex DNA sequence required for site-specific recombination promoted by the FLP protein of yeast in vitro.
Nucleic acids research 1986;14(12):4787-802.
1986: L G Beatty; D Babineau-Clary; C Hogrefe; Paul D Sadowski
FLP site-specific recombinase of yeast 2-micron plasmid. Topological features of the reaction.
Journal of molecular biology 1986;188(4):529-44.
1986: B J Andrews; L G Beatty; Paul D Sadowski
Site-specific recombination of the yeast plasmid two-micron circle: intermediates in the binding process.
Basic life sciences 1986;40():407-24.
1985: R M Gronostajski; Paul D Sadowski
The FLP recombinase of the Saccharomyces cerevisiae 2 microns plasmid attaches covalently to DNA via a phosphotyrosyl linkage.
Molecular and cellular biology 1985;5(11):3274-9.
1985: R M Gronostajski; Paul D Sadowski
The FLP protein of the 2-micron plasmid of yeast. Inter- and intramolecular reactions.
The Journal of biological chemistry 1985;260(22):12328-35.
1985: R M Gronostajski; Paul D Sadowski
Determination of DNA sequences essential for FLP-mediated recombination by a novel method.
The Journal of biological chemistry 1985;260(22):12320-7.
1985: D Babineau; D Vetter; B J Andrews; R M Gronostajski; G A Proteau; L G Beatty; Paul D Sadowski
The FLP protein of the 2-micron plasmid of yeast. Purification of the protein from Escherichia coli cells expressing the cloned FLP gene.
The Journal of biological chemistry 1985;260(22):12313-9.
1985: D D Lee; Paul D Sadowski
In vitro concatemerization of bacteriophage T7 DNA: role of DNA synthesis and gene 6 exonuclease.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire 1985;63(4):237-42.
1985: B J Andrews; G A Proteau; L G Beatty; Paul D Sadowski
The FLP recombinase of the 2 micron circle DNA of yeast: interaction with its target sequences.
Cell 1985;40(4):795-803.
1985: D Lee; D Vetter; L Beatty; Paul D Sadowski
In vitro recombination of bacteriophage T7 DNA: further characterization of the reaction using plasmid DNA.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire 1985;63(4):243-8.
1984: Paul D Sadowski; D D Lee; B J Andrews; D Babineau; L Beatty; M J Morse; G Proteau; D Vetter
In vitro systems for genetic recombination of the DNAs of bacteriophage T7 and yeast 2-micron circle.
Cold Spring Harbor symposia on quantitative biology 1984;49():789-96.
1982: D D Lee; Paul D Sadowski
Bacteriophage T7 defective in the gene 6 exonuclease promotes site-specific cleavages of T7 DNA in vivo and in vitro.
Journal of virology 1982;44(1):235-40.