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Yasuyuki Sadzuka

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TOP 3
Michiko Miyashita; Yasuyuki Sadzuka
Effect of linalool as a component of Humulus lupulus on doxorubicin-induced antitumor activity.
Ikumi Sugiyama; Yasuyuki Sadzuka
Enhanced antitumor activity of different double arms polyethyleneglycol-modified liposomal doxorubicin.
Yasuyuki Sadzuka; Yuko Ibuki; Makiko Nagamine; Tatsushi Toyooka; Takashi Sonobe
Beneficial effects of curcumin on antitumor activity and adverse reactions of doxorubicin.

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All Publications

2013: Michiko Miyashita; Yasuyuki Sadzuka
Effect of linalool as a component of Humulus lupulus on doxorubicin-induced antitumor activity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013;53():174-9.
2013: Ikumi Sugiyama; Yasuyuki Sadzuka
Enhanced antitumor activity of different double arms polyethyleneglycol-modified liposomal doxorubicin.
International journal of pharmaceutics 2013;441(1-2):279-84.
2012: Yasuyuki Sadzuka; Yuko Ibuki; Makiko Nagamine; Tatsushi Toyooka; Takashi Sonobe
Beneficial effects of curcumin on antitumor activity and adverse reactions of doxorubicin.
International journal of pharmaceutics 2012;432(1-2):42-9.
2012: Yasuyuki Sadzuka; Ikumi Sugiyama; Tomohiro Ueda; Sayaka Kikuchi; Michiko Miyashita; Eriko Oshiro; Akira Yano; Hidetoshi Yamada
Beneficial effects by intake of Euphausiacea pacifica on high-fat diet-induced obesity.
Biological & pharmaceutical bulletin 2012;35(4):568-72.
2011: Ikumi Sugiyama; Yasuyuki Sadzuka
Correlation of fixed aqueous layer thickness around PEG-modified liposomes with in vivo efficacy of antitumor agent-containing liposomes.
Current drug discovery technologies 2011;8(4):357-66.
2011: Ikumi Sugiyama; Yasuyuki Sadzuka
[Preparation of liposome using egg yolk].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2011;131(10):1519-25.
2010: Ikumi Sugiyama; Kenzo Kudo; Katsuo Takahashi; Yasuyuki Sadzuka
[Utility and improvement of liposome injections AmBisome for clinical use].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(3):457-61.
2010: Yasuyuki Sadzuka; Haruna Hatakeyama; Takashi Sonobe
Enhancement of doxorubicin concentration in the M5076 ovarian sarcoma cells by cucurbitacin E co-treatment.
International journal of pharmaceutics 2010;383(1-2):186-91.
2009: Yasuyuki Sadzuka; Makoto Matsuura; Takashi Sonobe
The effect of taurine, a novel biochemical modulator, on the antitumor activity of doxorubicin.
Biological & pharmaceutical bulletin 2009;32(9):1584-7.
2009: Ikumi Sugiyama; Takashi Sonobe; Yasuyuki Sadzuka
Effect of hybridized liposome by novel modification with some polyethyleneglycol-lipids.
International journal of pharmaceutics 2009;372(1-2):177-83.
2008: Yasuyuki Sadzuka; Fumiaki Iwasaki; Ikumi Sugiyama; Kentaro Horiuchi; Toru Hirano; Hidechika Ozawa; Naohiro Kanayama; Naoto Oku
Phototoxicity of coproporphyrin as a novel photodynamic therapy was enhanced by liposomalization.
Toxicology letters 2008;182(1-3):110-4.
2008: Noritaka Sakurai; Kazuyuki Suzuki; Yuki Sano; Teruyoshi Saito; Hisashi Yoshimura; Yukie Nishimura; Tomohiro Yano; Yasuyuki Sadzuka; Ryuji Asano
Effects of a single-dose administration of Bowman-Birk inhibitor concentrate on anti-proliferation and inhabitation of metastasis in M5076 ovarian sarcoma-bearing mice.
Molecular medicine reports 2008;1(6):903-7.
2008: Noritaka Sakurai; Kazuyuki Suzuki; Tetsuya Nagaoka; Teruyoshi Saito; Hisashi Yoshimura; Tomohiro Yano; Yasuyuki Sadzuka; Ryuji Asano
Connexin 43-dependent tumor-suppressing effect of the Bowman-Birk protease inhibitor on M5076 ovarian sarcoma-bearing mice.
Molecular medicine reports 2008;1(5):689-93.
2008: Yoshiaki Itoh; Akira Shimazu; Yasuyuki Sadzuka; Takashi Sonobe; Shigeru Itai
Novel method for stratum corneum pore size determination using positron annihilation lifetime spectroscopy.
International journal of pharmaceutics 2008;358(1-2):91-5.
2008: Yasuyuki Sadzuka; Kouhei Nakagawa; Hisashi Yoshioka; Takashi Sonobe
A liposomal formulation study of 2,7-dichlorodihydrofluorescein for detection of reactive oxygen species.
International journal of pharmaceutics 2008;356(1-2):300-5.
2008: Takahiko Nakamori; Atsuo Miyagishim; Yasuo Nozawa; Yasuyuki Sadzuka; Takashi Sonobe
Influence of load on particle size distribution of lactose-crystalline cellulose mixed powder.
International journal of pharmaceutics 2008;354(1-2):255-9.
2008: Yasuyuki Sadzuka; Haruna Hatakeyama; Takashi Daimon; Takashi Sonobe
Screening of biochemical modulator by tumor cell permeability of doxorubicin.
International journal of pharmaceutics 2008;354(1-2):63-9.
2007: Yasuyuki Sadzuka; Fumiaki Iwasaki; Ikumi Sugiyama; Kentaro Horiuchi; Toru Hirano; Hidechika Ozawa; Naohiro Kanayama; Takashi Sonobe
Study on liposomalization of zinc-coproporphyrin I as a novel drug in photodynamic therapy.
International journal of pharmaceutics 2007;338(1-2):306-9.
2007: Yasuyuki Sadzuka; Takashi Sonobe
Anserine induced advantage effects on the antitumor activity of doxorubicin.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(6):985-9.
2007: Ikumi Sugiyama; Yasuyuki Sadzuka
Characterization of novel mixed polyethyleneglycol modified liposomes.
Biological & pharmaceutical bulletin 2007;30(1):208-11.
2006: Yasuyuki Sadzuka; Koji Tokutomi; Fumiaki Iwasaki; Ikumi Sugiyama; Toru Hirano; Hiroyuki Konno; Naoto Oku; Takashi Sonobe
The phototoxicity of photofrin was enhanced by PEGylated liposome in vitro.
Cancer letters 2006;241(1):42-8.
2006: Yasuyuki Sadzuka; Ikumi Sugiyama; Tomoko Tsuruda; Takashi Sonobe
Characterization and cytotoxicity of mixed polyethyleneglycol modified liposomes containing doxorubicin.
International journal of pharmaceutics 2006;312(1-2):83-9.
2006: Seitaro Kamiya; Yasuo Nozawa; Atsuo Miyagishima; Takurou Kurita; Yasuyuki Sadzuka; Takashi Sonobe
Physical characteristics of freeze-dried griseofulvin-lipids nanoparticles.
Chemical & pharmaceutical bulletin 2006;54(2):181-4.
2006: Yasuyuki Sadzuka; Tomomi Sugiyama; Makiko Nagamine; Keizo Umegaki; Takashi Sonobe
Efficacy of theanine is connected with theanine metabolism by any enzyme, not only drug metabolizing enzymes.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(2):286-92.
2005: Yasuyuki Sadzuka; Hiroyuki Takabe; Takashi Sonobe
Liposomalization of SN-38 as active metabolite of CPT-11.
Journal of controlled release : official journal of the Controlled Release Society 2005;108(2-3):453-9.
2005: Yasuyuki Sadzuka; Chieko Inoue; Saho Hirooka; Tomomi Sugiyama; Keizo Umegaki; Takashi Sonobe
Effects of theanine on alcohol metabolism and hepatic toxicity.
Biological & pharmaceutical bulletin 2005;28(9):1702-6.
2005: Kazuyuki Suzuki; Tomohiro Yano; Yasuyuki Sadzuka; Tomomi Sugiyama; Taichiro Seki; Ryuji Asano
Restoration of connexin 43 by Bowman-Birk protease inhibitor in M5076 bearing mice.
Oncology reports 2005;13(6):1247-50.
2005: K Shimizu; T Asai; C Fuse; Yasuyuki Sadzuka; Takashi Sonobe; K Ogino; T Taki; T Tanaka; N Oku
Applicability of anti-neovascular therapy to drug-resistant tumor: suppression of drug-resistant P388 tumor growth with neovessel-targeted liposomal adriamycin.
International journal of pharmaceutics 2005;296(1-2):133-41.
2005: Hiroyuki Aoshima; Atsuo Miyagisnima; Yasuo Nozawa; Yasuyuki Sadzuka; Takashi Sonobe
Glycerin fatty acid esters as a new lubricant of tablets.
International journal of pharmaceutics 2005;293(1-2):25-34.
2005: Yasuyuki Sadzuka; Tomoko Tsuruda; Takashi Sonobe
[Characterization and cytotoxicity of mixed PEG-DSG modified liposomes].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2005;125(1):149-57.
2004: Noriyuki Maeda; Yoshito Takeuchi; Miki Takada; Yasuyuki Sadzuka; Yukihiro Namba; Naoto Oku
Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome.
Journal of controlled release : official journal of the Controlled Release Society 2004;100(1):41-52.
2004: Tomomi Sugiyama; Yasuyuki Sadzuka
Theanine, a specific glutamate derivative in green tea, reduces the adverse reactions of doxorubicin by changing the glutathione level.
Cancer letters 2004;212(2):177-84.
2004: Takurou Kurita; Atsuo Miyagishima; Yasuo Nozawa; Yasuyuki Sadzuka; Takashi Sonobe
A dosage design of mitomycin C tablets containing finely powdered green tea.
International journal of pharmaceutics 2004;275(1-2):279-83.
2004: Yasuyuki Sadzuka; Tomomi Sugiyama; Hirokazu Suzuki; Hiroyuki Sawanishi; Ken-Ichi Miyamoto
Increased effects of MPDAX, a novel xanthine derivative, on antitumor activity of doxorubicin.
Toxicology letters 2004;150(3):341-9.
2004: Tatsuhiro Ishida; Takako Ichikawa; Masako Ichihara; Yasuyuki Sadzuka; Hiroshi Kiwada
Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(3):403-12.
2004: Masami Kondo; Tomohiro Asai; Yasufumi Katanasaka; Yasuyuki Sadzuka; Hideo Tsukada; Koichi Ogino; Takao Taki; Kazuhiko Baba; Naoto Oku
Anti-neovascular therapy by liposomal drug targeted to membrane type-1 matrix metalloproteinase.
International journal of cancer. Journal international du cancer 2004;108(2):301-6.
2003: Tomomi Sugiyama; Yasuyuki Sadzuka
Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents.
Biochimica et biophysica acta 2003;1653(2):47-59.
2003: Akira Igarashi; Hiroyuki Konno; Tatsuo Tanaka; Satoshi Nakamura; Yasuyuki Sadzuka; Toru Hirano; Yutaka Fujise
Liposomal photofrin enhances therapeutic efficacy of photodynamic therapy against the human gastric cancer.
Toxicology letters 2003;145(2):133-41.
2003: Yasuyuki Sadzuka; Akiko Nakade; Tomoko Tsuruda; Takashi Sonobe
Study on the characterization of mixed polyethyleneglycol modified liposomes containing doxorubicin.
Journal of controlled release : official journal of the Controlled Release Society 2003;91(3):271-80.
2003: Yasuyuki Sadzuka; Kaori Kishi; Sadao Hirota; Takashi Sonobe
Effect of polyethyleneglycol (PEG) chain on cell uptake of PEG-modified liposomes.
Journal of liposome research 2003;13(2):157-72.
2002: Masataka Saito; Takashi Ugajin; Yasuo Nozawa; Yasuyuki Sadzuka; Atsuo Miyagishima; Takashi Sonobe
Preparation and dissolution characteristics of griseofulvin solid dispersions with saccharides.
International journal of pharmaceutics 2002;249(1-2):71-9.
2002: Yasuyuki Sadzuka; Yasuyo Yamashita; Takashi Sonobe
Effects of glutamate transporter inhibitors on the antitumor activity of doxorubicin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(12):3943-7.
2002: Yasuyuki Sadzuka; Yasuyo Yamashita; Shuichi Kishimoto; Shoji Fukushima; Yoshikazu Takeuchi; Takashi Sonobe
[Glutamate transporter mediated increase of antitumor activity by theanine, an amino acid in green tea].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2002;122(11):995-9.
2002: Yasuyuki Sadzuka; Youichi Egawa; Hiroyuki Sawanishi; Ken-ichi Miyamoto; Takashi Sonobe
Effects of xanthine derivatives on the influx and efflux of doxorubicin in P388 and DOX-resistant P388 leukemia cells.
Toxicology letters 2002;135(1-2):137-44.
2002: Yasuyuki Sadzuka; Yasuyo Yamashita; Tomomi Sugiyama; Takashi Sonobe
Effect of dihydrokainate on the antitumor activity of doxorubicin.
Cancer letters 2002;179(2):157-63.
2002: Yasuyuki Sadzuka; Akiko Nakade; Rieko Hirama; Atsuo Miyagishima; Yasuo Nozawa; Sadao Hirota; Takashi Sonobe
Effects of mixed polyethyleneglycol modification on fixed aqueous layer thickness and antitumor activity of doxorubicin containing liposome.
International journal of pharmaceutics 2002;238(1-2):171-80.
2002: Katsuhito Nagai; Kazuki Nagasawa; Yasuyuki Sadzuka; Masayuki Tsujimoto; Kohji Takara; Noriaki Ohnishi; Teruyoshi Yokoyama; Sadaki Fujimoto
Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma cells, and comparison with those in Ehrlich ascites carcinoma cells.
Cancer chemotherapy and pharmacology 2002;49(3):244-50.
2002: Yasuyuki Sadzuka; Rieko Hirama; Takashi Sonobe
Effects of intraperitoneal administration of liposomes and methods of preparing liposomes for local therapy.
Toxicology letters 2002;126(2):83-90.
2001: Yasuyuki Sadzuka; Tomomi Sugiyama; T Suzuki; Takashi Sonobe
Enhancement of the activity of doxorubicin by inhibition of glutamate transporter.
Toxicology letters 2001;123(2-3):159-67.
2001: Tomomi Sugiyama; Yasuyuki Sadzuka; K Tanaka; Takashi Sonobe
Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin.
Toxicology letters 2001;121(2):89-96.
2000: Yasuyuki Sadzuka; Tomomi Sugiyama; Takashi Sonobe
Improvement of idarubicin induced antitumor activity and bone marrow suppression by theanine, a component of tea.
Cancer letters 2000;158(2):119-24.
2000: K Shimada; S Matsuo; Yasuyuki Sadzuka; Atsuo Miyagishima; Yasuo Nozawa; Sadao Hirota; Takashi Sonobe
Determination of incorporated amounts of poly(ethylene glycol)-derivatized lipids in liposomes for the physicochemical characterization of stealth liposomes.
International journal of pharmaceutics 2000;203(1-2):255-63.
2000: Yasuyuki Sadzuka; Sadao Hirota; Takashi Sonobe
Intraperitoneal administration of doxorubicin encapsulating liposomes against peritoneal dissemination.
Toxicology letters 2000;116(1-2):51-9.
2000: Yasuyuki Sadzuka; Y Egawa; Tomomi Sugiyama; Hiroyuki Sawanishi; Ken-ichi Miyamoto; Takashi Sonobe
Effects of 1-methyl-3-propyl-7-butylxanthine (MPBX) on idarubicin-induced antitumor activity and bone marrow suppression.
Japanese journal of cancer research : Gann 2000;91(6):651-7.
2000: Yasuyuki Sadzuka; Tomomi Sugiyama; Takashi Sonobe
Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance.
Toxicology letters 2000;114(1-3):155-62.
1999: Tomomi Sugiyama; Yasuyuki Sadzuka; K Nagasawa; N Ohnishi; T Yokoyama; Takashi Sonobe
Membrane transport and antitumor activity of pirarubicin, and comparison with those of doxorubicin.
Japanese journal of cancer research : Gann 1999;90(7):775-80.
1999: Yasuyuki Sadzuka; Tomomi Sugiyama; Hiroyuki Sawanishi; Ken-ichi Miyamoto
Enhanced efficacy of 1-methyl-3-propyl-7-butylxanthine on the antitumor activity of doxorubicin against doxorubicin-resistant P388 leukemia.
Cancer letters 1999;138(1-2):5-11.
1999: Yasuyuki Sadzuka; S Hirotsu; Sadao Hirota
Effective irinotecan (CPT-11)-containing liposomes: intraliposomal conversion to the active metabolite SN-38.
Japanese journal of cancer research : Gann 1999;90(2):226-32.
1999: Tomomi Sugiyama; Yasuyuki Sadzuka
Combination of theanine with doxorubicin inhibits hepatic metastasis of M5076 ovarian sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(2):413-6.
1998: Tomomi Sugiyama; Yasuyuki Sadzuka
Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma.
Cancer letters 1998;133(1):19-26.
1998: Yasuyuki Sadzuka; Sadao Hirota
Does the amount of an antitumor agent entrapped in liposomes influence its tissue distribution and cell uptake?
Cancer letters 1998;131(2):163-70.
1998: Yasuyuki Sadzuka; S Hirotsu; Sadao Hirota
Effect of liposomalization on the antitumor activity, side-effects and tissue distribution of CPT-11.
Cancer letters 1998;127(1-2):99-106.
1998: Yasuyuki Sadzuka; A Iwazaki; Sadao Hirota
[Effects of methylxanthine derivatives on antitumor activity and toxic side effect of adriamycin induced by inhibition of DNA biosynthesis].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1998;118(5):179-87.
1998: Yasuyuki Sadzuka; A Iwazaki; Tomomi Sugiyama; T Sawanishi; Ken-ichi Miyamoto
1-Methyl-3-propyl-7-butylxanthine, a novel biochemical modulator, enhances therapeutic efficacy of adriamycin.
Japanese journal of cancer research : Gann 1998;89(2):228-33.
1998: Yasuyuki Sadzuka; Tomomi Sugiyama; S Hirota
Modulation of cancer chemotherapy by green tea.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(1):153-6.
1997: Yasuyuki Sadzuka; Tomomi Sugiyama; Kayoko Shimoi; Naohide Kinae; Sadao Hirota
Protective effect of flavonoids on doxorubicin-induced cardiotoxicity.
Toxicology letters 1997;92(1):1-7.
1997: Yasuyuki Sadzuka; Sadao Hirota
Effect of CPT-11 on lipid peroxide level in mouse tissues.
Japanese journal of cancer research : Gann 1997;88(5):512-6.
1997: Yasuyuki Sadzuka; S Nakai; Atsuo Miyagishima; Yasuo Nozawa; Sadao Hirota
Effects of administered route on tissue distribution and antitumor activity of polyethyleneglycol-coated liposomes containing adriamycin.
Cancer letters 1997;111(1-2):77-86.
1996: Yasuyuki Sadzuka; Tomomi Sugiyama; A Miyagishima; Y Nozawa; Sadao Hirota
The effects of theanine, as a novel biochemical modulator, on the antitumor activity of adriamycin.
Cancer letters 1996;105(2):203-9.
1995: Yasuyuki Sadzuka; A Iwazaki; A Miyagishima; Y Nozawa; Sadao Hirota
Effects of methylxanthine derivatives on adriamycin concentration and antitumor activity.
Japanese journal of cancer research : Gann 1995;86(6):594-9.
1995: K Shimada; A Miyagishima; Yasuyuki Sadzuka; Y Nozawa; Y Mochizuki; H Ohshima; Sadao Hirota
Determination of the thickness of the fixed aqueous layer around polyethyleneglycol-coated liposomes.
Journal of drug targeting 1995;3(4):283-9.
1995: Yasuyuki Sadzuka; E Mochizuki; Y Takino
Mechanism of caffeine modulation of the antitumor activity of adriamycin.
Toxicology letters 1995;75(1-3):39-49.
1995: Yasuyuki Sadzuka; E Mochizuki; A Iwazaki; Sadao Hirota; Y Takino
Caffeine enhances adriamycin antitumor activity in Ehrlich ascites carcinoma-bearing mice.
Biological & pharmaceutical bulletin 1995;18(1):159-61.
1995: Yasuyuki Sadzuka; S Nakai; A Miyagishima; Y Nozawa; Sadao Hirota
The effect of dose on the distribution of adriamycin encapsulated in polyethyleneglycol-coated liposomes.
Journal of drug targeting 1995;3(1):31-7.
1994: Yasuyuki Sadzuka; Y Shimizu; Y Takino; S Hirota
Protection against cisplatin-induced nephrotoxicity in the rat by inducers and an inhibitor of glutathione S-transferase.
Biochemical pharmacology 1994;48(3):453-9.
1994: Yasuyuki Sadzuka; Y Shimizu; Y Takino
Role of glutathione S-transferase isoenzymes in cisplatin-induced nephrotoxicity in the rat.
Toxicology letters 1994;70(2):211-22.
1993: Yasuyuki Sadzuka; E Mochizuki; Y Takino
Caffeine modulates the antitumor activity and toxic side effects of adriamycin.
Japanese journal of cancer research : Gann 1993;84(3):348-53.
1992: Yasuyuki Sadzuka; T Shoji; Y Takino
Mechanism of the increase in lipid peroxide induced by cisplatin in the kidneys of rats.
Toxicology letters 1992;62(2-3):293-300.
1992: Yasuyuki Sadzuka; Y Takino
Effect of seasonal variation on lipid peroxide level and glutathione peroxidase activity in the mouse before and after adriamycin administration.
Toxicology letters 1992;61(1):49-56.
1992: Yasuyuki Sadzuka; Y Takino
Effect of tetrahydropyranyladriamycin (THP-ADR) and 4'-epiadriamycin (4'-epi-ADR) on lipid peroxide levels in mice.
Chemical & pharmaceutical bulletin 1992;40(5):1329-31.
1992: Yasuyuki Sadzuka; T Shoji; Y Takino
Effect of cisplatin on the activities of enzymes which protect against lipid peroxidation.
Biochemical pharmacology 1992;43(8):1872-5.
1991: Yasuyuki Sadzuka; T Shoji; Y Takino
Change of lipid peroxide levels in rat tissues after cisplatin administration.
Toxicology letters 1991;57(2):159-66.