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Stephen Safe

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TOP 3
KYOUNGHYUN Kim; S Kim; Robert C. Burghardt; G Chadalapaka; J Frank; G Johnson; I Jutooru; Stephen Safe
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer.
Stephen Safe
Endocrine disruptors and falling sperm counts: lessons learned or not!
Gayathri Chadalapaka; Candy Chen; Lisa Crose; Indira Jutooru; KYOUNGHYUN Kim; Corinne Linardic; Satya Pathi; Sandeep Sreevalsan; Stephen Safe
Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors.

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All Publications

2013: KYOUNGHYUN Kim; S Kim; Robert C. Burghardt; G Chadalapaka; J Frank; G Johnson; I Jutooru; Stephen Safe
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer.
Oncogene 2013;32(13):1616-25.
2013: Stephen Safe
Endocrine disruptors and falling sperm counts: lessons learned or not!
Asian journal of andrology 2013;15(2):191-4.
2013: Gayathri Chadalapaka; Candy Chen; Lisa Crose; Indira Jutooru; KYOUNGHYUN Kim; Corinne Linardic; Satya Pathi; Sandeep Sreevalsan; Stephen Safe
Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors.
International journal of cancer. Journal international du cancer 2013;132(4):795-806.
2013: Armando Del Follo-Martinez; Xiangrong Li; Nivedita Banerjee; Stephen Safe; Susanne U Mertens-Talcott
Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a.
Nutrition and cancer 2013;65(3):494-504.
2013: Ji-Ae Shin; Ji-Youn Jung; Mi Heon Ryu; Stephen Safe; Sung-Dae Cho
Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization.
Molecular pharmacology 2013;83(1):33-41.
2012: Nivedita Banerjee; Stephen Safe; Stephen Talcott; Susanne U Mertens-Talcott
Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation.
Breast cancer research and treatment 2012;136(1):21-34.
2012: Un-Ho Jin; Syng-Ook Lee; Stephen Safe
Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells.
The Journal of pharmacology and experimental therapeutics 2012;343(2):333-41.
2012: KYOUNGHYUN Kim; Ju Seog Lee; Yun-Yong Park; Satya S Pathi; Gayathri Chadalapaka; Sudhakar Chintharlapalli; Sung-Gook Cho; Un-Ho Jin; Stephen Safe
Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters.
Molecular cancer therapeutics 2012;11(9):1852-62.
2012: Xinyi Liu; Paul L Prather; Lisa K Brents; Indira Jutooru; KYOUNGHYUN Kim; Syng-Ook Lee; Ping Lei; Stephen Safe
Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.
Molecular cancer therapeutics 2012;11(7):1421-31.
2012: H Wilson; S Sheppard; G Chadalapaka; I Jutooru; C Pfent; Stephen Safe
Effect of tolfenamic acid on canine cancer cell proliferation, specificity protein (sp) transcription factors, and sp-regulated proteins in canine osteosarcoma, mammary carcinoma, and melanoma cells.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2012;26(4):977-86.
2012: Guoqing Zhuang; Patali S Cheruku; Ashley R Evans; Xin Guo; Honggui Li; Cong Meng; Stephen Safe; Lei Shi; Gang Wang; Chaodong Wu; Hang Xu; Beiyan Zhou
A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation.
Circulation 2012;125(23):2892-903.
2012: Gayathri Chadalapaka; Indira Jutooru; Stephen Safe
Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells.
Carcinogenesis 2012;33(4):886-94.
2012: KYOUNGHYUN Kim; J-S Lee; Syng-Ook Lee; Y-Y Park; G Chadalapaka; Pierre-Antoine Defossez; X Sastre-Garau; D Yamada; Stephen Safe
Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer.
Oncogene 2012;31(8):1034-44.
2012: Shruti U Gandhy; KYOUNGHYUN Kim; Lesley Larsen; Rhonda J Rosengren; Stephen Safe
Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs.
BMC cancer 2012;12():564.
2012: Satya Pathi; Gayathri Chadalapaka; Indira Jutooru; Syng-Ook Lee; Vijayalekshmi Nair; Stephen Safe
Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors.
PloS one 2012;7(10):e48208.
2011: Ji-Ae Shin; Nam-Pyo Cho; Eun-Sun Choi; Ki Han Kwon; Syng-Ook Lee; Dae-Ho Leem; Stephen Safe; Jung-Hyun Shim; Sung-Dae Cho
Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2011;20(5):417-25.
2011: Sudhakar Chintharlapalli; Un-Ho Jin; Syng-Ook Lee; Ping Lei; Sabitha Papineni; Libero Santarpia; Steven I Sherman; Stephen Safe
Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins.
Molecular carcinogenesis 2011;50(9):655-67.
2011: Rola Barhoumi; Youssef Mouneimne; Ernesto Ramos; Christophe Morisseau; Bruce D Hammock; Stephen Safe; Alan R Parrish; Robert C. Burghardt
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line.
Toxicology and applied pharmacology 2011;253(1):45-56.
2011: KYOUNGHYUN Kim; Robert C. Burghardt; Rola Barhoumi; Syng-Ook Lee; Xinyi Liu; Stephen Safe
MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cells.
Journal of molecular endocrinology 2011;46(2):67-79.
2011: Satya S Pathi; Indira Jutooru; Gayathri Chadalapaka; Sandeep Sreevalsan; S Anand; Gregory R J Thatcher; Stephen Safe
GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway.
Molecular cancer research : MCR 2011;9(2):195-202.
2011: Satya S Pathi; Gayathri Chadalapaka; Indira Jutooru; Ping Lei; Sandeep Sreevalsan; Stephen Safe
Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.
Nutrition and cancer 2011;63(7):1133-42.
2011: Sudhakar Chintharlapalli; Ping Lei; Sabitha Papineni; Satya Pathi; Stephen Safe
Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.
BMC cancer 2011;11():371.
2010: Xiufeng Pang; Li Zhang; Yougen Wu; Lei Lin; Jingjie Li; Weijing Qu; Stephen Safe; Mingyao Liu
Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor.
The Journal of pharmacology and experimental therapeutics 2010;335(1):172-9.
2010: Stephen Safe
3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters.
Toxicological sciences : an official journal of the Society of Toxicology 2010;117(1):1-3.
2010: Indira Jutooru; Gayathri Chadalapaka; Ping Lei; Stephen Safe
Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.
The Journal of biological chemistry 2010;285(33):25332-44.
2010: Indira Jutooru; Gayathri Chadalapaka; Maen Abdelrahim; Md Riyaz Basha; Ismael Samudio; Marina Konopleva; Michael Andreeff; Stephen Safe
Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a.
Molecular pharmacology 2010;78(2):226-36.
2010: Indira Jutooru; Gayathri Chadalapaka; Sandeep Sreevalsan; Ping Lei; Rola Barhoumi; Robert C. Burghardt; Stephen Safe
Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth.
Experimental cell research 2010;316(13):2174-88.
2010: Twee Tsao; Steven M Kornblau; Stephen Safe; Julie C Watt; Vivian Ruvolo; Wenjing Chen; Yihua Qiu; Kevin R Coombes; Zhenlin Ju; Maen Abdelrahim; Wendy D Schober; Xiaoyang Ling; Dimitris Kardassis; Colin Meyer; Aaron D Schimmer; Andrew Lamb; Michael Andreeff; Marina Konopleva
Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia.
Cancer research 2010;70(12):4949-60.
2010: Xiangrong Li; Susanne U Mertens-Talcott; Shu Zhang; KYOUNGHYUN Kim; Judith Ball; Stephen Safe
MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells.
Endocrinology 2010;151(6):2462-73.
2010: Gayathri Chadalapaka; Indira Jutooru; Robert C. Burghardt; Stephen Safe
Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells.
Molecular cancer research : MCR 2010;8(5):739-50.
2010: Jingjing Guo; Sudhakar Chintharlapalli; Syng-Ook Lee; Sung Dae Cho; Ping Lei; Sabitha Papineni; Stephen Safe
Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells.
Cancer chemotherapy and pharmacology 2010;66(1):141-50.
2010: Sung Dae Cho; Syng-Ook Lee; Sudhakar Chintharlapalli; Maen Abdelrahim; Shaheen Khan; Kyungsil Yoon; Ashish M Kamat; Stephen Safe
Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth.
Molecular pharmacology 2010;77(3):396-404.
2010: Kathy Vanderlaag; Yunpeng Su; Arthur E Frankel; Robert C. Burghardt; Rola Barhoumi; Gayathri Chadalapaka; Indira Jutooru; Stephen Safe
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.
BMC cancer 2010;10():669.
2009: Sandeep Sreevalsan; Indira Jutooru; Gayathri Chadalapaka; Michael Walker; Stephen Safe
1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells.
International journal of oncology 2009;35(5):1191-9.
2009: Sudhakar Chintharlapalli; Sabitha Papineni; Maen Abdelrahim; Ala Abudayyeh; Indira Jutooru; Gayathri Chadalapaka; Fei Wu; Susanne U Mertens-Talcott; Kathy Vanderlaag; Sung-Dae Cho; Roger Smith; Stephen Safe
Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells.
International journal of cancer. Journal international du cancer 2009;125(8):1965-74.
2009: Shu Zhang; Ping Lei; Xinyi Liu; Xiangrong Li; Kelcey Walker; Leela Kotha; Craig Rowlands; Stephen Safe
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy.
Endocrine-related cancer 2009;16(3):835-44.
2009: Indira Jutooru; Gayathri Chadalapaka; Sudhakar Chintharlapalli; Sabitha Papineni; Stephen Safe
Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative.
Molecular carcinogenesis 2009;48(8):692-702.
2009: Syng-Ook Lee; Sudhakar Chintharlapalli; Shengxi Liu; Sabitha Papineni; Sung-Dae Cho; Kyungsil Yoon; Stephen Safe
p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells.
Molecular cancer research : MCR 2009;7(7):1169-78.
2009: Sabitha Papineni; Sudhakar Chintharlapalli; Maen Abdelrahim; Syng-Ook Lee; Robert C. Burghardt; Ala Abudayyeh; Cheryl Baker; Luis Herrera; Stephen Safe
Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met.
Carcinogenesis 2009;30(7):1193-201.
2009: Xinyi Liu; Maen Abdelrahim; Ala Abudayyeh; Ping Lei; Stephen Safe
The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression.
Molecular cancer therapeutics 2009;8(5):1207-17.
2009: Rola Barhoumi; Jeffrey M Catania; Alan R Parrish; Igbal Awooda; Evelyn Tiffany-Castiglioni; Stephen Safe; Robert C. Burghardt
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines.
The Journal of toxicological sciences 2009;34(1):13-25.
2008: Stephen Safe; KYOUNGHYUN Kim; Kyoungkim Kim
Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways.
Journal of molecular endocrinology 2008;41(5):263-75.
2008: Fei Wu; Rui Xu; KYOUNGHYUN Kim; James Martin; Stephen Safe
In vivo profiling of estrogen receptor/specificity protein-dependent transactivation.
Endocrinology 2008;149(11):5696-705.
2008: Stephen Safe; Sabitha Papineni; Sudhakar Chintharlapalli
Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs.
Cancer letters 2008;269(2):326-38.
2008: Ping Lei; Maen Abdelrahim; Sung Dae Cho; Xinyi Liu; Xingi Liu; Stephen Safe
Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3'-indoly)-1-(p-substituted phenyl)methanes.
Molecular cancer therapeutics 2008;7(10):3363-72.
2008: Sung Dae Cho; Sudhakar Chintharlapalli; Maen Abdelrahim; Sabitha Papineni; Shengxi Liu; Jingjing Guo; Ping Lei; Ala Abudayyeh; Stephen Safe
5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells.
Molecular cancer therapeutics 2008;7(7):2109-20.
2008: Gayathri Chadalapaka; Indira Jutooru; Sudhakar Chintharlapalli; Sabitha Papineni; Roger Smith; Xiangrong Li; Stephen Safe
Curcumin decreases specificity protein expression in bladder cancer cells.
Cancer research 2008;68(13):5345-54.
2008: Jun Hong; Ismael Samudio; Sudhakar Chintharlapalli; Stephen Safe
1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines.
Molecular carcinogenesis 2008;47(7):492-507.
2008: Ping Lei; Maen Abdelrahim; Sung Dae Cho; Shengxi Liu; Sudhakar Chintharlapalli; Stephen Safe
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase.
Carcinogenesis 2008;29(6):1139-47.
2008: Lisbeth A Pacheco-Palencia; Stephen T Talcott; Stephen Safe; Susanne Mertens-Talcott
Absorption and biological activity of phytochemical-rich extracts from açai (Euterpe oleracea Mart.) pulp and oil in vitro.
Journal of agricultural and food chemistry 2008;56(10):3593-600.
2008: Fei Wu; Shaheen Khan; Qian Wu; Rola Barhoumi; Robert C. Burghardt; Stephen Safe
Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens.
The Journal of steroid biochemistry and molecular biology 2008;110(1-2):104-15.
2008: Kathy Vanderlaag; Yunpeng Su; Arthur E Frankel; Henry Grage; Roger Smith; Shaheen Khan; Stephen Safe
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways.
Breast cancer research and treatment 2008;109(2):273-83.
2008: Gayathri Chadalapaka; Indira Jutooru; Alan McAlees; Tom Stefanac; Stephen Safe
Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives.
Bioorganic & medicinal chemistry letters 2008;18(8):2633-9.
2008: Sung Dae Cho; Ping Lei; Maen Abdelrahim; Kyungsil Yoon; Shengxi Liu; Jingjing Guo; Sabitha Papineni; Sudhakar Chintharlapalli; Stephen Safe
1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells.
Molecular carcinogenesis 2008;47(4):252-63.
2008: Shu Zhang; Craig Rowlands; Stephen Safe
Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay.
Toxicology and applied pharmacology 2008;227(2):196-206.
2008: Ronald B Tjalkens; Xuhong Liu; Brianne Mohl; Tyler Wright; Julie A Moreno; David L Carbone; Stephen Safe
The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells.
Journal of neuroscience research 2008;86(3):618-29.
2008: Kelly Higgins; Shengxi Liu; Maen Abdelrahim; Kathy Vanderlaag; Xinyi Liu; Weston Porter; Richard P Metz; Stephen Safe
Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins.
Molecular endocrinology (Baltimore, Md.) 2008;22(2):388-402.
2008: Sabitha Papineni; Sudhakar Chintharlapalli; Stephen Safe
Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells.
Molecular pharmacology 2008;73(2):553-65.
2007: Susanne U Mertens-Talcott; Sudhakar Chintharlapalli; Xiangrong Li; Stephen Safe
The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells.
Cancer research 2007;67(22):11001-11.
2007: Melissa York; Maen Abdelrahim; Sudhakar Chintharlapalli; Salina D Lucero; Stephen Safe
1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce apoptosis and inhibit renal cell carcinoma growth.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(22 Pt 1):6743-52.
2007: Sudhakar Chintharlapalli; Sabitha Papineni; Shengxi Liu; Indira Jutooru; Gayathri Chadalapaka; Sung Dae Cho; Rajesh S Murthy; Youngjae You; Stephen Safe
2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells.
Carcinogenesis 2007;28(11):2337-46.
2007: Shaheen Khan; Fei Wu; Shengxi Liu; Qian Wu; Stephen Safe
Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells.
Journal of molecular endocrinology 2007;39(4):289-304.
2007: Shaheen Khan; Shengxi Liu; Matthew Stoner; Stephen Safe
Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells.
Toxicology and applied pharmacology 2007;223(1):28-38.
2007: Jeongeun Lee; Stephen Safe
Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150).
Archives of biochemistry and biophysics 2007;461(2):200-10.
2007: Sudhakar Chintharlapalli; Sabitha Papineni; Indira Jutooru; Alan McAlees; Stephen Safe
Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells.
Molecular cancer therapeutics 2007;6(5):1588-98.
2007: Maen Abdelrahim; Cheryl H Baker; James L Abbruzzese; David Sheikh-Hamad; Shengxi Liu; Sung Dae Cho; Kyungsil Yoon; Stephen Safe
Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells.
Cancer research 2007;67(7):3286-94.
2007: Sudhakar Chintharlapalli; Sabitha Papineni; Shashi K Ramaiah; Stephen Safe
Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.
Cancer research 2007;67(6):2816-23.
2007: Sudhakar Chintharlapalli; Sabitha Papineni; Stephen Safe
1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in LNCaP prostate cancer cells through peroxisome proliferator-activated receptor gamma-independent pathways.
Molecular pharmacology 2007;71(2):558-69.
2007: Sung Dae Cho; Kyungsil Yoon; Sudhakar Chintharlapalli; Maen Abdelrahim; Ping Lei; Stanley Hamilton; Shaheen Khan; Shashi K Ramaiah; Stephen Safe
Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways.
Cancer research 2007;67(2):674-83.
2007: Yunpeng Su; Kathy Vanderlaag; Courtney Ireland; Janelle Ortiz; Henry Grage; Stephen Safe; Arthur E Frankel
1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice.
Breast cancer research : BCR 2007;9(4):R56.
2007: Fei Wu; Stephen Safe
Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2007;103(1):1-9.
2006: Shaheen Khan; Alex Konstantinov; Brock Chittim; Alan McAlees; Brian Yeo; Stephen Safe
Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes.
Toxicology in vitro : an international journal published in association with BIBRA 2006;20(7):1234-7.
2006: Ping Lei; Maen Abdelrahim; Stephen Safe
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator-activated receptor-dependent and independent pathways.
Molecular cancer therapeutics 2006;5(9):2324-36.
2006: Shengxi Liu; Maen Abdelrahim; Shaheen Khan; Eric A Ariazi; V Craig Jordan; Stephen Safe
Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells.
Biological chemistry 2006;387(9):1209-13.
2006: Shaheen Khan; Rola Barhoumi; Robert C. Burghardt; Shengxi Liu; KYOUNGHYUN Kim; Stephen Safe
Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2006;20(9):2199-214.
2006: Wan Ru Lee; Chien-Cheng Chen; Shengxi Liu; Stephen Safe
17beta-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways.
Journal of cellular biochemistry 2006;99(1):209-20.
2006: Rola Barhoumi; Igbal Awooda; Youssef Mouneimne; Stephen Safe; Robert C. Burghardt
Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.
Toxicology letters 2006;165(2):133-41.
2006: Stephen Safe; Sabitha Papineni
The role of xenoestrogenic compounds in the development of breast cancer.
Trends in pharmacological sciences 2006;27(8):447-54.
2006: Kelly Higgins; Shengxi Liu; Maen Abdelrahim; Kyungsil Yoon; Kathy Vanderlaag; Weston Porter; Richard P Metz; Stephen Safe
Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.
Endocrinology 2006;147(7):3285-95.
2006: Kelly Higgins; Maen Abdelrahim; Shengxi Liu; Kyungsil Yoon; Stephen Safe
Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins.
Biochemical and biophysical research communications 2006;345(1):292-301.
2006: Maen Abdelrahim; Cheryl H Baker; James L Abbruzzese; Stephen Safe
Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation.
Journal of the National Cancer Institute 2006;98(12):855-68.
2006: Kathy Vanderlaag; Ismael Samudio; Robert C. Burghardt; Rola Barhoumi; Stephen Safe
Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM.
Cancer letters 2006;236(2):198-212.
2006: Sudhakar Chintharlapalli; Sabitha Papineni; Stephen Safe
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways.
Molecular cancer therapeutics 2006;5(5):1362-70.
2006: Maen Abdelrahim; Kristen Newman; Kathy Vanderlaag; Ismael Samudio; Stephen Safe
3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.
Carcinogenesis 2006;27(4):717-28.
2006: Maen Abdelrahim; Eric A Ariazi; KYOUNGHYUN Kim; Shaheen Khan; Rola Barhoumi; Robert C. Burghardt; Shengxi Liu; Denise Hill; Richard Finnell; Bogdan Wlodarczyk; V Craig Jordan; Stephen Safe
3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha.
Cancer research 2006;66(4):2459-67.
2006: Xiangrong Li; Shu Zhang; Stephen Safe
Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds.
The Journal of steroid biochemistry and molecular biology 2006;98(2-3):122-32.
2006: Dianne C Mitchell; Maen Abdelrahim; Jinsheng Weng; Lewis J Stafford; Stephen Safe; Menashe Bar-Eli; Mingyao Liu
Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1.
The Journal of biological chemistry 2006;281(1):51-8.
2006: Wassim Kassouf; Sudhakar Chintharlapalli; Maen Abdelrahim; Gina M Nelkin; Stephen Safe; Ashish M Kamat
Inhibition of bladder tumor growth by 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes: a new class of peroxisome proliferator-activated receptor gamma agonists.
Cancer research 2006;66(1):412-8.
2005: Ismael Samudio; Marina Konopleva; Stephen Safe; Teresa McQueen; Michael Andreeff
Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure.
Molecular cancer therapeutics 2005;4(12):1982-92.
2005: Sudhakar Chintharlapalli; Sabitha Papineni; Seung Joon Baek; Shengxi Liu; Stephen Safe
1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1.
Molecular pharmacology 2005;68(6):1782-92.
2005: Stephen Safe; Maen Abdelrahim
Sp transcription factor family and its role in cancer.
European journal of cancer (Oxford, England : 1990) 2005;41(16):2438-48.
2005: Ismael Samudio; Marina Konopleva; Numsen Hail; Yue-Xi Shi; Teresa McQueen; Timothy Hsu; Randall Evans; Tadashi Honda; Gordon W Gribble; Michael B. Sporn; Hiram F Gilbert; Stephen Safe; Michael Andreeff
2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.
The Journal of biological chemistry 2005;280(43):36273-82.
2005: Maen Abdelrahim; Stephen Safe
Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins.
Molecular pharmacology 2005;68(2):317-29.
2005: Sudhakar Chintharlapalli; Robert C. Burghardt; Sabitha Papineni; Shashi K Ramaiah; Kyungsil Yoon; Stephen Safe
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.
The Journal of biological chemistry 2005;280(26):24903-14.
2005: Sudhakar Chintharlapalli; Sabitha Papineni; Marina Konopleva; Michael Andreef; Ismael Samudio; Stephen Safe
2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways.
Molecular pharmacology 2005;68(1):119-28.
2005: Stephen Safe
Clinical correlates of environmental endocrine disruptors.
Trends in endocrinology and metabolism: TEM 2005;16(4):139-44.
2005: Maen Abdelrahim; Shengxi Liu; Stephen Safe
Induction of endoplasmic reticulum-induced stress genes in Panc-1 pancreatic cancer cells is dependent on Sp proteins.
The Journal of biological chemistry 2005;280(16):16508-13.
2005: KYOUNGHYUN Kim; Rola Barhoumi; Robert C. Burghardt; Stephen Safe
Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer.
Molecular endocrinology (Baltimore, Md.) 2005;19(4):843-54.
2005: Jeongeun Eun Lee; KYOUNGHYUN Kim; James C Sacchettini; Clare V Smith; Stephen Safe
DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.
The Journal of biological chemistry 2005;280(10):8819-30.
2004: Qian Wu; Robert C. Burghardt; Stephen Safe
Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins.
The Journal of biological chemistry 2004;279(51):53602-12.
2004: Stephen Safe
Endocrine disruptors and human health: is there a problem.
Toxicology 2004;205(1-2):3-10.
2004: Jun Hong; Ismael Samudio; Shengxi Liu; Maen Abdelrahim; Stephen Safe
Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins.
Endocrinology 2004;145(12):5774-85.
2004: Chien-Cheng Chen; Wan-Ru Lee; Stephen Safe
Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1.
Journal of cellular biochemistry 2004;93(5):1063-74.
2004: Maen Abdelrahim; Roger Smith; Robert C. Burghardt; Stephen Safe
Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells.
Cancer research 2004;64(18):6740-9.
2004: Sudhakar Chintharlapalli; Roger Smith; Ismael Samudio; Wei Zhang; Stephen Safe
1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor gamma-mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells.
Cancer research 2004;64(17):5994-6001.
2004: Xiangrong Li; Chunhua Qin; Robert C. Burghardt; Stephen Safe
Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells.
Biochemical and biophysical research communications 2004;320(3):625-34.
2004: Chunhua Qin; Ismael Samudio; Sharon Ngwenya; Stephen Safe
Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways.
Molecular carcinogenesis 2004;40(3):160-70.
2004: Sandra Timm Pearce; Hong Liu; Ishwar Radhakrishnan; Maen Abdelrahim; Stephen Safe; V Craig Jordan
Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8-trichlorodibenzofuran with estrogen receptor alpha.
Cancer research 2004;64(8):2889-97.
2004: Chunhua Qin; Derek Morrow; Jessica Stewart; Kyle Spencer; Weston Porter; Roger Smith; Timothy Phillips; Maen Abdelrahim; Ismael Samudio; Stephen Safe
A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes.
Molecular cancer therapeutics 2004;3(3):247-60.
2004: Matthew Stoner; Mark Wormke; Bradley Saville; Ismael Samudio; Chunhua Qin; Maen Abdelrahim; Stephen Safe
Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins.
Oncogene 2004;23(5):1052-63.
2004: Stephen Safe; KYOUNGHYUN Kim
Nuclear receptor-mediated transactivation through interaction with Sp proteins.
Progress in nucleic acid research and molecular biology 2004;77():1-36.
2004: Derek Morrow; Chunhua Qin; Roger Smith; Stephen Safe
Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.
The Journal of steroid biochemistry and molecular biology 2004;88(1):27-36.
2003: Stephen Safe; Mark Wormke
Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action.
Chemical research in toxicology 2003;16(7):807-16.
2003: Maen Abdelrahim; Roger Smith; Stephen Safe
Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells.
Molecular pharmacology 2003;63(6):1373-81.
2003: Shaheen Khan; Maen Abdelrahim; Ismael Samudio; Stephen Safe
Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells.
Endocrinology 2003;144(6):2325-35.
2003: Sharon Ngwenya; Stephen Safe
Cell context-dependent differences in the induction of E2F-1 gene expression by 17 beta-estradiol in MCF-7 and ZR-75 cells.
Endocrinology 2003;144(5):1675-85.
2003: KYOUNGHYUN Kim; Nguyen Thu; Bradley Saville; Stephen Safe
Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2003;17(5):804-17.
2003: Chunhua Qin; Robert C. Burghardt; Roger Smith; Mark Wormke; Jessica Stewart; Stephen Safe
Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.
Cancer research 2003;63(5):958-64.
2003: Mark Wormke; Matthew Stoner; Bradley Saville; Kelcey Walker; Maen Abdelrahim; Robert C. Burghardt; Stephen Safe
The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes.
Molecular and cellular biology 2003;23(6):1843-55.
2003: Emely Castro-Rivera; Stephen Safe
17 beta-estradiol- and 4-hydroxytamoxifen-induced transactivation in breast, endometrial and liver cancer cells is dependent on ER-subtype, cell and promoter context.
The Journal of steroid biochemistry and molecular biology 2003;84(1):23-31.
2002: CA Vyhlidal; X Li; Stephen Safe
Estrogen regulation of transferrin gene expression in MCF-7 human breast cancer cells.
Journal of molecular endocrinology 2002;29(3):305-17.
2002: Stephen Safe
Environmental estrogens: roles in male reproductive tract problems and in breast cancer.
Reviews on environmental health 2002;17(4):253-62.
2002: Matthew Stoner; Bradley Saville; Mark Wormke; Dana Dean; Robert C. Burghardt; Stephen Safe
Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2002;16(10):2231-42.
2002: Maen Abdelrahim; Ismael Samudio; Roger Smith; Robert C. Burghardt; Stephen Safe
Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells.
The Journal of biological chemistry 2002;277(32):28815-22.
2002: Chunhua Qin; Thu Nguyen; Jessica Stewart; Ismael Samudio; Robert C. Burghardt; Stephen Safe
Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex.
Molecular endocrinology (Baltimore, Md.) 2002;16(8):1793-809.
2002: Renqin Duan; Wen Xie; Xiangrong Li; Andrew McDougal; Stephen Safe
Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells.
Biochemical and biophysical research communications 2002;294(2):384-94.
2002: Stephen Safe; Andrew McDougal
Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review).
International journal of oncology 2002;20(6):1123-8.
2002: Katrina L Mealey; Rola Barhoumi; Robert C. Burghardt; Stephen Safe; Deborah T Kochevar
Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells.
Antimicrobial agents and chemotherapy 2002;46(3):755-61.
2002: Bradley Saville; Hetti Poukka; Mark Wormke; Olli A Janne; Jorma J Palvimo; Matthew Stoner; Ismael Samudio; Stephen Safe
Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein.
The Journal of biological chemistry 2002;277(4):2485-97.
2001: JE Lee; Stephen Safe
Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells.
Biochemical pharmacology 2001;62(8):1113-24.
2001: Emely Castro-Rivera; Ismael Samudio; Stephen Safe
Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements.
The Journal of biological chemistry 2001;276(33):30853-61.
2001: Kyungsil Yoon; Lea Pallaroni; M Stoner; Kevin W Gaido; Stephen Safe
Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements.
The Journal of steroid biochemistry and molecular biology 2001;78(1):25-32.
2001: Wen Xie; Renqin Duan; Stephen Safe
Activation of adenosine deaminase in MCF-7 cells through IGF-estrogen receptor alpha crosstalk.
Journal of molecular endocrinology 2001;26(3):217-28.
2001: Andrew McDougal; Mark Wormke; J Calvin; Stephen Safe
Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator.
Cancer research 2001;61(10):3902-7.
2001: Renqin Duan; Wen Xie; Robert C. Burghardt; Stephen Safe
Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1.
The Journal of biological chemistry 2001;276(15):11590-8.
2001: Chunhua Qin; C Wilson; C Blancher; M Taylor; Stephen Safe; A L Harris
Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):818-23.
2001: Stephen Safe
Molecular biology of the Ah receptor and its role in carcinogenesis.
Toxicology letters 2001;120(1-3):1-7.
2001: Ismael Samudio; CA Vyhlidal; Fen Wang; Matthew Stoner; I Chen; Michael P Kladde; Rola Barhoumi; Robert C. Burghardt; Stephen Safe
Transcriptional activation of deoxyribonucleic acid polymerase alpha gene expression in MCF-7 cells by 17 beta-estradiol.
Endocrinology 2001;142(3):1000-8.
2001: Fen Wang; Ismael Samudio; Stephen Safe
Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.
Molecular and cellular endocrinology 2001;172(1-2):91-103.
2001: Weston Porter; Fen Wang; Renqin Duan; Chunhua Qin; Emely Castro-Rivera; KYOUNGHYUN Kim; Stephen Safe
Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists.
Journal of molecular endocrinology 2001;26(1):31-42.
2001: I Chen; T Hsieh; T Thomas; Stephen Safe
Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization.
Gene 2001;262(1-2):207-14.
2001: Fen Wang; Ismael Samudio; Stephen Safe
Transcriptional activation of rat creatine kinase B by 17beta-estradiol in MCF-7 cells involves an estrogen responsive element and GC-rich sites.
Journal of cellular biochemistry 2001;84(1):156-72.
2001: Stephen Safe
Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions.
Vitamins and hormones 2001;62():231-52.
2000: JE Lee; Stephen Safe
3',4'-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells.
Toxicological sciences : an official journal of the Society of Toxicology 2000;58(2):235-42.
2000: Kevin W Gaido; SC Maness; Donald P McDonnell; Shangara S Dehal; David Kupfer; Stephen Safe
Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies.
Molecular pharmacology 2000;58(4):852-8.
2000: Stephen Safe
Bisphenol A and related endocrine disruptors.
Toxicological sciences : an official journal of the Society of Toxicology 2000;56(2):251-2.
2000: Mark Wormke; Matthew Stoner; Bradley Saville; Stephen Safe
Crosstalk between estrogen receptor alpha and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes.
FEBS letters 2000;478(1-2):109-12.
2000: Matthew Stoner; Fen Wang; Mark Wormke; Thu Nguyen; Ismael Samudio; CA Vyhlidal; D Marme; G Finkenzeller; Stephen Safe
Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins.
The Journal of biological chemistry 2000;275(30):22769-79.
2000: Stephen Safe; Mark Wormke; Ismael Samudio
Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells.
Journal of mammary gland biology and neoplasia 2000;5(3):295-306.
2000: Wen Xie; Renqin Duan; I Chen; Ismael Samudio; Stephen Safe
Transcriptional activation of thymidylate synthase by 17beta-estradiol in MCF-7 human breast cancer cells.
Endocrinology 2000;141(7):2439-49.
2000: CA Vyhlidal; Ismael Samudio; Michael P Kladde; Stephen Safe
Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-site.
Journal of molecular endocrinology 2000;24(3):329-38.
2000: Kyungsil Yoon; L Pellaroni; K Ramamoorthy; Kevin W Gaido; Stephen Safe
Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines.
Molecular and cellular endocrinology 2000;162(1-2):211-20.
2000: Mark Wormke; Emely Castro-Rivera; I Chen; Stephen Safe
Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells.
The Journal of steroid biochemistry and molecular biology 2000;72(5):197-207.
2000: Bradley Saville; Mark Wormke; Fen Wang; Thu Nguyen; E Enmark; George G J M Kuiper; Jan-�ke GUSTAFSSON; Stephen Safe
Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements.
The Journal of biological chemistry 2000;275(8):5379-87.
1999: Kevin W Gaido; LS Leonard; SC Maness; J M Hall; Donald P McDonnell; B Saville; Stephen Safe
Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta.
Endocrinology 1999;140(12):5746-53.
1999: L Dong; Wei Wang; Fen Wang; Matthew Stoner; J C Reed; M Harigai; Ismael Samudio; Michael P Kladde; CA Vyhlidal; Stephen Safe
Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells.
The Journal of biological chemistry 1999;274(45):32099-107.
1999: Stephen Safe; Michael J Wargovich; C A Lamartiniere; H Mukhtar
Symposium on mechanisms of action of naturally occurring anticarcinogens.
Toxicological sciences : an official journal of the Society of Toxicology 1999;52(1):1-8.
1999: Stephen Safe; C Qin; Andrew McDougal
Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer.
Expert opinion on investigational drugs 1999;8(9):1385-96.
1999: Renqin Duan; Weston Porter; Ismael Samudio; CA Vyhlidal; Michael P Kladde; Stephen Safe
Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.
Molecular endocrinology (Baltimore, Md.) 1999;13(9):1511-21.
1999: Fen Wang; Wei Wang; Stephen Safe
Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl hydrocarbon receptor complex.
Biochemistry 1999;38(35):11490-500.
1999: Wei Wang; L Dong; Bradley Saville; Stephen Safe
Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions.
Molecular endocrinology (Baltimore, Md.) 1999;13(8):1373-87.
1999: Thu Nguyen; DJ Hoivik; JE Lee; Stephen Safe
Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex.
Archives of biochemistry and biophysics 1999;367(2):250-7.
1999: Chunhua Qin; P Singh; Stephen Safe
Transcriptional activation of insulin-like growth factor-binding protein-4 by 17beta-estradiol in MCF-7 cells: role of estrogen receptor-Sp1 complexes.
Endocrinology 1999;140(6):2501-8.
1999: Emely Castro-Rivera; Mark Wormke; Stephen Safe
Estrogen and aryl hydrocarbon responsiveness of ECC-1 endometrial cancer cells.
Molecular and cellular endocrinology 1999;150(1-2):11-21.
1999: Wen Xie; Renqin Duan; Stephen Safe
Estrogen induces adenosine deaminase gene expression in MCF-7 human breast cancer cells: role of estrogen receptor-Sp1 interactions.
Endocrinology 1999;140(1):219-27.
1998: Stephen Safe; K Connor; Kevin W Gaido
Methods for xenoestrogen testing.
Toxicology letters 1998;102-103():665-70.
1998: Stephen Safe; Fen Wang; Weston Porter; Renqin Duan; Andrew McDougal
Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms.
Toxicology letters 1998;102-103():343-7.
1998: M Gupta; Andrew McDougal; Stephen Safe
Estrogenic and antiestrogenic activities of 16alpha- and 2-hydroxy metabolites of 17beta-estradiol in MCF-7 and T47D human breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1998;67(5-6):413-9.
1998: Kevin W Gaido; L Dohme; Fen Wang; I Chen; B Blankvoort; K Ramamoorthy; Stephen Safe
Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food.
Environmental health perspectives 1998;106 Suppl 6():1347-51.
1998: Lawrence S Goldstein; Eric H Weyand; Stephen Safe; M Steinberg; Sandra J Culp; David W Gaylor; Frederick A Beland; Lewis V Rodriguez
Tumors and DNA adducts in mice exposed to benzo[a]pyrene and coal tars: implications for risk assessment.
Environmental health perspectives 1998;106 Suppl 6():1325-30.
1998: C L Wilson; Stephen Safe
Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses.
Toxicologic pathology 1998;26(5):657-71.
1998: I Chen; Andrew McDougal; Fen Wang; Stephen Safe
Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane.
Carcinogenesis 1998;19(9):1631-9.
1998: Wei Wang; Roger Smith; Stephen Safe
Aryl hydrocarbon receptor-mediated antiestrogenicity in MCF-7 cells: modulation of hormone-induced cell cycle enzymes.
Archives of biochemistry and biophysics 1998;356(2):239-48.
1998: J C Gould; LS Leonard; SC Maness; BL Wagner; K Conner; Timothy R Zacharewski; Stephen Safe; Donald P McDonnell; Kevin W Gaido
Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.
Molecular and cellular endocrinology 1998;142(1-2):203-14.
1998: Fen Wang; DJ Hoivik; R Pollenz; Stephen Safe
Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes.
Nucleic acids research 1998;26(12):3044-52.
1998: G Sun; Weston Porter; Stephen Safe
Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex.
Molecular endocrinology (Baltimore, Md.) 1998;12(6):882-90.
1998: Renqin Duan; Weston Porter; Stephen Safe
Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation.
Endocrinology 1998;139(4):1981-90.
1998: Andrew McDougal; Stephen Safe
Induction of 16alpha-/2-hydroxyestrone metabolite ratios in MCF-7 cells by pesticides, carcinogens, and antiestrogens does not predict mammary carcinogens.
Environmental health perspectives 1998;106(4):203-6.
1998: Emely Castro-Rivera; Stephen Safe
Estrogen- and antiestrogen-responsiveness of HEC1A endometrial adenocarcinoma cells in culture.
The Journal of steroid biochemistry and molecular biology 1998;64(5-6):287-95.
1997: DJ Hoivik; C Wilson; Wei Wang; Kristine L Willett; Rola Barhoumi; Robert C. Burghardt; Stephen Safe
Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells.
Archives of biochemistry and biophysics 1997;348(1):174-82.
1997: DJ Hoivik; Kristine L Willett; C Wilson; Stephen Safe
Estrogen does not inhibit 2,3,7, 8-tetrachlorodibenzo-p-dioxin-mediated effects in MCF-7 and Hepa 1c1c7 cells.
The Journal of biological chemistry 1997;272(48):30270-4.
1997: Andrew McDougal; C Wilson; Stephen Safe
Inhibition of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor growth by aryl hydrocarbon receptor agonists.
Cancer letters 1997;120(1):53-63.
1997: K Ramamoorthy; CA Vyhlidal; Fen Wang; I Chen; Stephen Safe; Donald P McDonnell; L S Leonard; Kevin W Gaido
Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol.
Toxicology and applied pharmacology 1997;147(1):93-100.
1997: Weston Porter; Bradley Saville; DJ Hoivik; Stephen Safe
Functional synergy between the transcription factor Sp1 and the estrogen receptor.
Molecular endocrinology (Baltimore, Md.) 1997;11(11):1569-80.
1997: Stephen Safe; K Connor; K Ramamoorthy; Kevin W Gaido; S Maness
Human exposure to endocrine-active chemicals: hazard assessment problems.
Regulatory toxicology and pharmacology : RTP 1997;26(1 Pt 1):52-8.
1997: A McDougal; C Wilson; Stephen Safe
Induction of estradiol 2-hydroxylase activity in MCF-7 human breast cancer cells by pesticides and carcinogens.
Environmental toxicology and pharmacology 1997;3(3):195-9.
1997: K Connor; K Ramamoorthy; M Moore; M Mustain; I Chen; Stephen Safe; Timothy R Zacharewski; B Gillesby; A Joyeux; Patrick Balaguer
Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships.
Toxicology and applied pharmacology 1997;145(1):111-23.
1997: Fen Wang; Weston Porter; W Xing; T K Archer; Stephen Safe
Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene.
Biochemistry 1997;36(25):7793-801.
1997: K Ramamoorthy; Fen Wang; I C Chen; John D Norris; Donald P McDonnell; L S Leonard; Kevin W Gaido; W P Bocchinfuso; K S Korach; Stephen Safe
Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism.
Endocrinology 1997;138(4):1520-7.
1997: K I Nodland; Mark Wormke; Stephen Safe
Inhibition of estrogen-induced activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-7 human breast cancer and other cell lines transfected with vitellogenin A2 gene promoter constructs.
Archives of biochemistry and biophysics 1997;338(1):67-72.
1997: K Ramamoorthy; Fen Wang; I C Chen; Stephen Safe; John D Norris; Donald P McDonnell; Kevin W Gaido; W P Bocchinfuso; K S Korach
Potency of combined estrogenic pesticides.
Science (New York, N.Y.) 1997;275(5298):405-6.
1997: Stephen Safe
Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds.
Teratogenesis, carcinogenesis, and mutagenesis 1997;17(4-5):285-304.
1997: G Sun; Stephen Safe
Antiestrogenic activities of alternate-substituted polychlorinated dibenzofurans in MCF-7 human breast cancer cells.
Cancer chemotherapy and pharmacology 1997;40(3):239-44.
1997: Lewis V Rodriguez; H A Dunsford; M Steinberg; K K Chaloupka; L Zhu; Stephen Safe; J E Womack; Lawrence S Goldstein
Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice.
Carcinogenesis 1997;18(1):127-35.
1997: M Moore; M Mustain; K Daniel; I Chen; Stephen Safe; Timothy R Zacharewski; B Gillesby; A Joyeux; Patrick Balaguer
Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum.
Toxicology and applied pharmacology 1997;142(1):160-8.
1996: Weston Porter; Fen Wang; Wei Wang; Renqin Duan; Stephen Safe
Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression.
Molecular endocrinology (Baltimore, Md.) 1996;10(11):1371-8.
1996: C Wilker; Larry Johnson; Stephen Safe
Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring.
Toxicology and applied pharmacology 1996;141(1):68-75.
1996: Y F Lu; G Sun; X Wang; Stephen Safe
Inhibition of prolactin receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 human breast cancer cells.
Archives of biochemistry and biophysics 1996;332(1):35-40.
1996: H Liu; Stephen Safe
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on insulin-induced responses in MCF-7 human breast cancer cells.
Toxicology and applied pharmacology 1996;138(2):242-50.
1996: M Santostefano; Stephen Safe
Characterization of the molecular and structural properties of the transformed and nuclear aryl hydrocarbon (Ah) receptor complexes by proteolytic digestion.
Chemico-biological interactions 1996;100(3):221-40.
1996: N Harper; M Steinberg; Stephen Safe
Immunotoxicity of a reconstituted polynuclear aromatic hydrocarbon mixture in B6C3F1 mice.
Toxicology 1996;109(1):31-8.
1996: Y F Lu; M Santostefano; B D Cunningham; Michael Threadgill; Stephen Safe
Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists.
Biochemical pharmacology 1996;51(8):1077-87.
1996: I Chen; Stephen Safe; L Bjeldanes
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells.
Biochemical pharmacology 1996;51(8):1069-76.
1996: M Moore; M Ruh; M Steinberg; Stephen Safe
Isolation and characterization of variant benzo[a]pyrene-resistant T47D human breast-cancer cells.
International journal of cancer. Journal international du cancer 1996;66(1):117-23.
1996: K Connor; J Howell; I Chen; H Liu; K Berhane; C Sciarretta; Stephen Safe; Timothy R Zacharewski
Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;30(1):93-101.
1996: W L Wang; J S Thomsen; Weston Porter; M Moore; Stephen Safe
Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells.
British journal of cancer 1996;73(3):316-22.
1995: Stephen Safe; V Krishnan
Chlorinated hydrocarbons: estrogens and antiestrogens.
Toxicology letters 1995;82-83():731-6.
1995: R Dickerson; L H Keller; Stephen Safe
Alkyl polychlorinated dibenzofurans and related compounds as antiestrogens in the female rat uterus: structure-activity studies.
Toxicology and applied pharmacology 1995;135(2):287-98.
1995: V Krishnan; Weston Porter; M Santostefano; X Wang; Stephen Safe
Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells.
Molecular and cellular biology 1995;15(12):6710-9.
1995: K Connor; Stephen Safe; Colin R Jefcoate; M Larsen
Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats.
Biochemical pharmacology 1995;50(11):1913-20.
1995: Mary F Ruh; Timothy R Zacharewski; K Connor; J Howell; I Chen; Stephen Safe
Naringenin: a weakly estrogenic bioflavonoid that exhibits antiestrogenic activity.
Biochemical pharmacology 1995;50(9):1485-93.
1995: X Wang; J S Thomsen; M Santostefano; R Rosengren; Stephen Safe; G H Perdew
Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines.
European journal of pharmacology 1995;293(3):191-205.
1995: M Merchant; Stephen Safe
In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by alpha-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct.
Biochemical pharmacology 1995;50(5):663-8.
1995: N Harper; K Connor; M Steinberg; Stephen Safe
Immunosuppressive activity of polychlorinated biphenyl mixtures and congeners: nonadditive (antagonistic) interactions.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1995;27(1):131-9.
1995: K Chaloupka; M Steinberg; M Santostefano; L V Rodriguez; L Goldstein; Stephen Safe
Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice.
Chemico-biological interactions 1995;96(3):207-21.
1995: N Harper; M Steinberg; J Thomsen; Stephen Safe
Halogenated aromatic hydrocarbon-induced suppression of the plaque-forming cell response in B6C3F1 splenocytes cultured with allogenic mouse serum: Ah receptor structure activity relationships.
Toxicology 1995;99(3):199-206.
1995: Y F Lu; M Santostefano; B D Cunningham; Michael Threadgill; Stephen Safe
Identification of 3'-methoxy-4'-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells.
Archives of biochemistry and biophysics 1995;316(1):470-7.
1995: Stephen Safe; V Krishnan
Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1995;17():99-115.
1994: K Chaloupka; M Santostefano; I S Goldfarb; G Liu; M J Myers; I B Tsyrolv; H V Gelboin; V Krishnan; Stephen Safe
Aryl hydrocarbon (Ah) receptor-independent induction of Cyp1a2 gene expression by acenaphthylene and related compounds in B6C3F1 mice.
Carcinogenesis 1994;15(12):2835-40.
1994: X Wang; Stephen Safe
Development of an in vitro model for investigating the formation of the nuclear Ah receptor complex in mouse Hepa 1c1c7 cells.
Archives of biochemistry and biophysics 1994;315(2):285-92.
1994: T R Narasimhan; A Craig; L Arellano; N Harper; L Howie; M Menache; L Birnbaum; Stephen Safe
Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1994;23(4):598-607.
1994: N Harper; K Connor; M Steinberg; Stephen Safe
An enzyme-linked immunosorbent assay (ELISA) specific for antibodies to TNP-LPS detects alterations in serum immunoglobulins and isotype switching in C57BL/6 and DBA/2 mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.
Toxicology 1994;92(1-3):155-67.
1994: H Liu; M Santostefano; Stephen Safe
2-Phenylphenanthridinone and related compounds: aryl hydrocarbon receptor agonists and suicide inactivators of P4501A1.
Archives of biochemistry and biophysics 1994;313(2):206-14.
1994: N Harper; X Wang; H Liu; Stephen Safe
Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists.
Molecular and cellular endocrinology 1994;104(1):47-55.
1994: M Holcomb; Stephen Safe
Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Cancer letters 1994;82(1):43-7.
1994: Y Lu; X Wang; Stephen Safe
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid in MCF-7 human breast cancer cells.
Toxicology and applied pharmacology 1994;127(1):1-8.
1994: M Santosfefano; H Liu; X Wang; K Chaloupka; Stephen Safe
Effect of ligand structure on formation and DNA binding properties of the transformed rat cytosolic aryl hydrocarbon receptor.
Chemical research in toxicology 1994;7(4):544-50.
1994: V Krishnan; X Wang; Stephen Safe
Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.
The Journal of biological chemistry 1994;269(22):15912-7.
1994: J S Thomsen; X Wang; Ronald Hines; Stephen Safe
Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor.
Carcinogenesis 1994;15(5):933-7.
1994: M Moore; X Wang; Y F Lu; Mark Wormke; A Craig; J H Gerlach; Robert C. Burghardt; Rola Barhoumi; Stephen Safe
Benzo[a]pyrene-resistant MCF-7 human breast cancer cells. A unique aryl hydrocarbon-nonresponsive clone.
The Journal of biological chemistry 1994;269(16):11751-9.
1994: P Fernandez; Robert C. Burghardt; R Smith; K Nodland; Stephen Safe
High passage T47D human breast cancer cells: altered endocrine and 2,3,7,8-tetrachlorodibenzo-p-dioxin responsiveness.
European journal of pharmacology 1994;270(1):53-65.
1993: N Harper; L Howie; K Connor; R Dickerson; Stephen Safe
Immunosuppressive effects of highly chlorinated biphenyls and diphenyl ethers on T-cell dependent and independent antigens in mice.
Toxicology 1993;85(2-3):123-35.
1993: K Chaloupka; N Harper; V Krishnan; M Santostefano; L V Rodriguez; Stephen Safe
Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists.
Chemico-biological interactions 1993;89(2-3):141-58.
1993: X Wang; Weston Porter; V Krishnan; T R Narasimhan; Stephen Safe
Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells.
Molecular and cellular endocrinology 1993;96(1-2):159-66.
1993: H Liu; M Santostefano; Y Lu; Stephen Safe
6-substituted 3,4-benzocoumarins: a new structural class of inducers and inhibitors of CYP1A1-dependent activity.
Archives of biochemistry and biophysics 1993;306(1):223-31.
1993: Stephen Safe
Development of bioassays and approaches for the risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.
Environmental health perspectives 1993;101 Suppl 3():317-25.
1993: M Moore; T R Narasimhan; M A Steinberg; X Wang; Stephen Safe
Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate.
Archives of biochemistry and biophysics 1993;305(2):483-8.
1993: N Harper; K Connor; Stephen Safe
Immunotoxic potencies of polychlorinated biphenyl (PCB), dibenzofuran (PCDF) and dibenzo-p-dioxin (PCDD) congeners in C57BL/6 and DBA/2 mice.
Toxicology 1993;80(2-3):217-27.
1993: M Merchant; V Krishnan; Stephen Safe
Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells.
Toxicology and applied pharmacology 1993;120(2):179-85.
1993: N Harper; L Howie; K Connor; L Arellano; A Craig; R Dickerson; Stephen Safe
Immunosuppressive and monooxygenase induction activities of highly chlorinated diphenyl ether congeners in C57BL/6 and DBA/2 mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;20(4):496-502.
1993: M Harris; Timothy R Zacharewski; Stephen Safe
Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats--assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs).
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;20(4):456-63.
1993: V Krishnan; Stephen Safe
Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships.
Toxicology and applied pharmacology 1993;120(1):55-61.
1993: C Rowlands; V Krishnan; X Wang; M Santostefano; Stephen Safe; W R Miller; S Langdon
Characterization of the aryl hydrocarbon receptor and aryl hydrocarbon responsiveness in human ovarian carcinoma cell lines.
Cancer research 1993;53(8):1802-7.
1993: Stephen Safe
Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems.
Environmental health perspectives 1993;100():259-68.
1993: M Moore; T R Narasimhan; X Wang; V Krishnan; Stephen Safe; H J Williams; A I Scott
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1993;44(3):251-61.
1993: L O Arellano; X Wang; Stephen Safe
Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines.
Carcinogenesis 1993;14(2):219-22.
1993: M Santostefano; M Merchant; L Arellano; V Morrison; M S Denison; Stephen Safe
alpha-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation.
Molecular pharmacology 1993;43(2):200-6.
1993: K Mayura; C B Spainhour; L Howie; Stephen Safe; Timothy D Phillips
Teratogenicity and immunotoxicity of 3,3',4,4',5-pentachlorobiphenyl in C57BL/6 mice.
Toxicology 1993;77(1-2):123-31.
1992: K Chaloupka; V Krishnan; Stephen Safe
Polynuclear aromatic hydrocarbon carcinogens as antiestrogens in MCF-7 human breast cancer cells: role of the Ah receptor.
Carcinogenesis 1992;13(12):2233-9.
1992: X Wang; M Santostefano; Y Lu; Stephen Safe
A comparison of the mouse versus human aryl hydrocarbon (Ah) receptor complex: effects of proteolysis.
Chemico-biological interactions 1992;85(1):79-93.
1992: M Merchant; V Morrison; M Santostefano; Stephen Safe
Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
Archives of biochemistry and biophysics 1992;298(2):389-94.
1992: H Liu; L Biegel; T R Narasimhan; C Rowlands; Stephen Safe
Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.
Molecular and cellular endocrinology 1992;87(1-3):19-28.
1992: M Santostefano; J Piskorska-Pliszczynska; V Morrison; Stephen Safe
Effects of ligand structure on the in vitro transformation of the rat cytosolic aryl hydrocarbon receptor.
Archives of biochemistry and biophysics 1992;297(1):73-9.
1992: C Yao; Stephen Safe
The interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in chick embryo hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 1992;6(4):373-80.
1992: V Krishnan; T Narasimhan; Stephen Safe
Development of gel staining techniques for detecting the secretion of procathepsin D (52-kDa protein) in MCF-7 human breast cancer cells.
Analytical biochemistry 1992;204(1):137-42.
1992: P Fernandez; Stephen Safe
Growth inhibitory and antimitogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in T47D human breast cancer cells.
Toxicology letters 1992;61(2-3):185-97.
1992: R Rosengren; Stephen Safe; N J Bunce
Kinetics of the association of several tritiated polychlorinated dibenzo-p-dioxin and dibenzofuran congeners with hepatic cytosolic Ah receptor from the Wistar rat.
Chemical research in toxicology 1992;5(3):376-82.
1992: X Wang; R Rosengren; V Morrison; M Santostefano; Stephen Safe
Characterization of the aryl hydrocarbon receptor in the human C-4II cervical squamous carcinoma cell line.
Biochemical pharmacology 1992;43(7):1635-42.
1992: Timothy R Zacharewski; M Harris; L Biegel; V Morrison; M Merchant; Stephen Safe
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor.
Toxicology and applied pharmacology 1992;113(2):311-8.
1992: R Dickerson; L Howie; Stephen Safe
The effect of 6-nitro-1,3,8-trichlorodibenzofuran as a partial estrogen in the female rat uterus.
Toxicology and applied pharmacology 1992;113(1):55-63.
1992: M Merchant; X Wang; C Kamps; R Rosengren; V Morrison; Stephen Safe
Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: role of the nuclear 6 s and 4 s proteins.
Archives of biochemistry and biophysics 1992;292(1):250-7.
1991: Stephen Safe; B Astroff; M Harris; Timothy R Zacharewski; R Dickerson; M Romkes; L Biegel
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action.
Pharmacology & toxicology 1991;69(6):400-9.
1991: T R Narasimhan; Stephen Safe; H J Williams; A I Scott
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced glucose metabolism in MCF-7 human breast cancer cells: 13C nuclear magnetic resonance spectroscopy studies.
Molecular pharmacology 1991;40(6):1029-35.
1991: J Piskorska-Pliszczynska; V Morrison; Timothy R Zacharewski; Stephen Safe
DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells.
Archives of biochemistry and biophysics 1991;290(2):362-8.
1991: Timothy R Zacharewski; M Harris; Stephen Safe
Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse Hepa 1c1c7 cells.
Biochemical pharmacology 1991;41(12):1931-9.
1991: X Wang; T R Narasimhan; V Morrison; Stephen Safe
In situ and in vitro photoaffinity labeling of the nuclear aryl hydrocarbon receptor from transformed rodent and human cell lines.
Archives of biochemistry and biophysics 1991;287(1):186-94.
1991: B Astroff; B Eldridge; Stephen Safe
Inhibition of the 17 beta-estradiol-induced and constitutive expression of the cellular protooncogene c-fos by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the female rat uterus.
Toxicology letters 1991;56(3):305-15.
1991: B Astroff; Stephen Safe
6-Alkyl-1,3,8-trichlorodibenzofurans as antiestrogens in female Sprague-Dawley rats.
Toxicology 1991;69(2):187-97.
1991: J Piskorska-Pliszczynska; B Astroff; Timothy R Zacharewski; M Harris; R Rosengren; V Morrison; L Safe; Stephen Safe
Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes.
Archives of biochemistry and biophysics 1991;284(1):193-200.
1991: Stephen Safe; M Harris; Timothy R Zacharewski
Development and validation of bioassays for polychlorinated dibenzo-p-dioxins and dibenzofurans.
IARC scientific publications 1991;(108):147-59.
1990: L Biegel; Stephen Safe
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cell growth and the secretion of the estrogen-induced 34-, 52- and 160-kDa proteins in human breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1990;37(5):725-32.
1990: B Astroff; C Rowlands; R Dickerson; Stephen Safe
2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17 beta-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression.
Molecular and cellular endocrinology 1990;72(3):247-52.
1990: M Harris; Timothy R Zacharewski; J Piskorska-Pliszczynska; R Rosengren; Stephen Safe
Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: mechanistic studies.
Toxicology and applied pharmacology 1990;105(2):243-53.
1990: L Howie; R Dickerson; D Davis; Stephen Safe
Immunosuppressive and monooxygenase induction activities of polychlorinated diphenyl ether congeners in C57BL/6N mice: quantitative structure-activity relationships.
Toxicology and applied pharmacology 1990;105(2):254-63.
1990: M Merchant; L Arellano; Stephen Safe
The mechanism of action of alpha-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
Archives of biochemistry and biophysics 1990;281(1):84-9.
1990: R Dickerson; L Howie; D Davis; Stephen Safe
The structure-dependent effects of heptachlorodibenzofuran isomers in male C57BL/6 mice: immunotoxicity and monooxygenase enzyme induction.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1990;15(2):298-307.
1990: D Davis; Stephen Safe
Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: structure-activity relationships as Ah receptor agonists and partial antagonists.
Toxicology 1990;63(1):97-111.
1990: M Kelley; J Womack; Stephen Safe
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins.
Biochemical pharmacology 1990;39(12):1991-8.
1990: M Harris; Timothy R Zacharewski; Stephen Safe
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells.
Cancer research 1990;50(12):3579-84.
1990: B Astroff; Stephen Safe
2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiestrogen: effect on rat uterine peroxidase activity.
Biochemical pharmacology 1990;39(3):485-8.
1990: Stephen Safe
Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).
Critical reviews in toxicology 1990;21(1):51-88.
1989: B Astroff; Stephen Safe
6-substituted-1,3,8-trichlorodibenzofurans as 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists in the rat: structure activity relationships.
Toxicology 1989;59(3):285-96.
1989: JP Landers; J Piskorska-Pliszczynska; Timothy R Zacharewski; Nigel J Bunce; Stephen Safe
Photoaffinity labeling of the nuclear Ah receptor from mouse Hepa 1c1c7 cells using 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.
The Journal of biological chemistry 1989;264(31):18463-71.
1989: Stephen Safe; G Mason; T Sawyer; Timothy R Zacharewski; M Harris; C Yao; B Keys; K Farrell; M Holcomb; D Davis
Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review.
Toxicology and industrial health 1989;5(5):757-75.
1989: C Yao; Stephen Safe
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies.
Toxicology and applied pharmacology 1989;100(2):208-16.
1989: M Harris; J Piskorska-Pliszczynska; Timothy R Zacharewski; M Romkes; Stephen Safe
Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor.
Cancer research 1989;49(16):4531-5.
1989: Timothy R Zacharewski; M Harris; Stephen Safe
Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners.
Archives of biochemistry and biophysics 1989;272(2):344-55.
1989: M Harris; Timothy R Zacharewski; B Astroff; Stephen Safe
Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies.
Molecular pharmacology 1989;35(5):729-35.
1989: L Biegel; M Harris; D Davis; R Rosengren; L Safe; Stephen Safe
2,2',4,4',5,5'-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice.
Toxicology and applied pharmacology 1989;97(3):561-71.
1989: R Bannister; L Biegel; D Davis; B Astroff; Stephen Safe
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice.
Toxicology 1989;54(2):139-50.
1989: M Makary; H L Kim; Stephen Safe; J Womack; GW Ivie
Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1989;92(2):171-4.
1988: J Piskorska-Pliszczynska; Stephen Safe
Radioligand-dependent differences in the molecular properties of the mouse and rat hepatic aryl hydrocarbon receptor complexes.
Archives of biochemistry and biophysics 1988;267(1):372-83.
1988: Timothy R Zacharewski; M Harris; Stephen Safe; H Thoma; O Hutzinger
Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining "2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents": pyrolyzed brominated flame retardants.
Toxicology 1988;51(2-3):177-89.
1988: B Astroff; Stephen Safe
Comparative antiestrogenic activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in the female rat.
Toxicology and applied pharmacology 1988;95(3):435-43.
1988: M Harris; C Kamps; Stephen Safe
Role of the 4-5S binding protein in the induction of aryl hydrocarbon hydroxylase in the rat.
Carcinogenesis 1988;9(8):1475-9.
1988: D Davis; Stephen Safe
Immunosuppressive activities of polychlorinated dibenzofuran congeners: quantitative structure-activity relationships and interactive effects.
Toxicology and applied pharmacology 1988;94(1):141-9.
1988: M Holcomb; C Yao; Stephen Safe
Biologic and toxic effects of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in the guinea pig. Quantitative structure-activity relationships.
Biochemical pharmacology 1988;37(8):1535-9.
1988: M Romkes; Stephen Safe
Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus.
Toxicology and applied pharmacology 1988;92(3):368-80.
1988: B Astroff; Timothy R Zacharewski; Stephen Safe; M P Arlotto; A Parkinson; P Thomas; W Levin
6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.
Molecular pharmacology 1988;33(2):231-6.
1988: Kirby C Donnelly; K W Brown; M Estiri; D H Jones; Stephen Safe
Mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p-dioxins and related compounds.
Journal of toxicology and environmental health 1988;24(3):345-56.
1988: J C Merrill; H L Kim; Stephen Safe; C A Murray; M A Hayes
Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin.
Journal of toxicology and environmental health 1988;23(2):159-69.
1988: M Makary; H L Kim; Stephen Safe; J Womack; GW Ivie
Constitutive and Aroclor 1254-induced hepatic glutathione S-transferase, peroxidase and reductase activities in genetically inbred mice.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1988;91(2):425-9.
1987: K Farrell; L Safe; Stephen Safe
Synthesis and aryl hydrocarbon receptor binding properties of radiolabeled polychlorinated dibenzofuran congeners.
Archives of biochemistry and biophysics 1987;259(1):185-95.
1987: M Romkes; J Piskorska-Pliszczynska; B Keys; Stephen Safe; T Fujita
Quantitative structure-activity relationships: analysis of interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2-substituted analogues with rat, mouse, guinea pig, and hamster cytosolic receptor.
Cancer research 1987;47(19):5108-11.
1987: J M Haake; Stephen Safe; K Mayura; Timothy D Phillips
Aroclor 1254 as an antagonist of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicology letters 1987;38(3):299-306.
1987: B Leece; M A Denomme; R Towner; A Li; JP Landers; Stephen Safe
Nonadditive interactive effects of polychlorinated biphenyl congeners in rats: role of the 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor.
Canadian journal of physiology and pharmacology 1987;65(9):1908-12.
1987: K Farrell; Stephen Safe
Absence of positive co-operativity in the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to its cytosolic receptor protein.
The Biochemical journal 1987;244(3):539-46.
1987: G Mason; Timothy R Zacharewski; M A Denomme; L Safe; Stephen Safe
Polybrominated dibenzo-p-dioxins and related compounds: quantitative in vivo and in vitro structure-activity relationships.
Toxicology 1987;44(3):245-55.
1987: M Romkes; J Piskorska-Pliszczynska; Stephen Safe
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats.
Toxicology and applied pharmacology 1987;87(2):306-14.
1986: J Piskorska-Pliszczynska; B Keys; Stephen Safe; M S Newman
The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons.
Toxicology letters 1986;34(1):67-74.
1986: G Mason; K Farrell; B Keys; J Piskorska-Pliszczynska; L Safe; Stephen Safe
Polychlorinated dibenzo-p-dioxins: quantitative in vitro and in vivo structure-activity relationships.
Toxicology 1986;41(1):21-31.
1986: B D Leece; M A Denomme; S M Li; R A Towner; J W Gyorkos; B G Chittim; Stephen Safe
Effects of individual terphenyls and polychlorinated terphenyls on rat hepatic microsomal cytochrome P-450-dependent monooxygenases: structure-activity relationships.
Archives of toxicology 1986;59(3):186-9.
1986: T Sawyer; D Jones; K Rosanoff; G Mason; J Piskorska-Pliszczynska; Stephen Safe
The biologic and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in chickens.
Toxicology 1986;39(2):197-206.
1986: B Keys; J Piskorska-Pliszczynska; Stephen Safe
Polychlorinated dibenzofurans as 2,3,7,8-TCDD antagonists: in vitro inhibition of monooxygenase enzyme induction.
Toxicology letters 1986;31(2):151-8.
1986: M A Denomme; K Homonko; T Fujita; T Sawyer; Stephen Safe
Substituted polychlorinated dibenzofuran receptor binding affinities and aryl hydrocarbon hydroxylase induction potencies--a QSAR analysis.
Chemico-biological interactions 1986;57(2):175-87.
1986: M A Denomme; B Leece; A Li; R Towner; Stephen Safe
Elevation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) polychlorinated biphenyls. Structure-activity relationships.
Biochemical pharmacology 1986;35(2):277-82.
1986: S M Li; M A Denomme; B Leece; Stephen Safe; D Dutton; A Parkinson; P E Thomas; D Ryan; S Bandiera; L M Reik
Hexachlorobenzene and substituted pentachlorobenzenes (X-C6Cl5) as inducers of hepatic cytochrome P-450-dependent mono-oxygenases.
IARC scientific publications 1986;(77):527-34.
1985: B Keys; M Hlavinka; G Mason; Stephen Safe
Modulation of rat hepatic microsomal testosterone hydroxylases by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related toxic isostereomers.
Canadian journal of physiology and pharmacology 1985;63(12):1537-42.
1985: G Mason; T Sawyer; B Keys; S Bandiera; M Romkes; J Piskorska-Pliszczynska; B Zmudzka; Stephen Safe
Polychlorinated dibenzofurans (PCDFs): correlation between in vivo and in vitro structure-activity relationships.
Toxicology 1985;37(1-2):1-12.
1985: Stephen Safe; S Bandiera; T Sawyer; B Zmudzka; G Mason; M Romkes; M A Denomme; J Sparling; A B Okey; T Fujita
Effects of structure on binding to the 2,3,7,8-TCDD receptor protein and AHH induction--halogenated biphenyls.
Environmental health perspectives 1985;61():21-33.
1985: M A Denomme; K Homonoko; T Fujita; T Sawyer; Stephen Safe
Effects of substituents on the cytosolic receptor-binding avidities and aryl hydrocarbon hydroxylase induction potencies of 7-substituted 2,3-dichlorodibenzo-p-dioxins. A quantitative structure-activity relationship analysis.
Molecular pharmacology 1985;27(6):656-61.
1985: Stephen Safe; S Bandiera; T Sawyer; L Robertson; L Safe; A Parkinson; P E Thomas; D E Ryan; L M Reik; W Levin
PCBs: structure-function relationships and mechanism of action.
Environmental health perspectives 1985;60():47-56.
1985: B Leece; M A Denomme; R Towner; S M Li; Stephen Safe
Polychlorinated biphenyls: correlation between in vivo and in vitro quantitative structure-activity relationships (QSARs).
Journal of toxicology and environmental health 1985;16(3-4):379-88.
1985: J Gyorkos; M A Denomme; B Leece; K Homonko; V E Valli; Stephen Safe
Reconstituted halogenated hydrocarbon pesticide and pollutant mixtures found in human tissues: effects on the immature male Wistar rat after short-term exposure.
Canadian journal of physiology and pharmacology 1985;63(1):36-43.
1984: S Bandiera; T Sawyer; M Romkes; B Zmudzka; L Safe; G Mason; B Keys; Stephen Safe
Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity.
Toxicology 1984;32(2):131-44.
1983: M A Denomme; S Bandiera; I Lambert; L Copp; L Safe; Stephen Safe
Polychlorinated biphenyls as phenobarbitone-type inducers of microsomal enzymes. Structure-activity relationships for a series of 2,4-dichloro-substituted congeners.
Biochemical pharmacology 1983;32(19):2955-63.
1983: J Andres; I Lambert; L Robertson; S Bandiera; T Sawyer; S Lovering; Stephen Safe
The comparative biologic and toxic potencies of polychlorinated biphenyls and polybrominated biphenyls.
Toxicology and applied pharmacology 1983;70(2):204-15.
1983: M A Denomme; B Leece; J Gyorkos; K Homonko; Stephen Safe
Polychlorinated benzene and phenol congeners as inducers of rat hepatic drug-metabolizing enzymes in immature male Wistar rats.
Canadian journal of physiology and pharmacology 1983;61(9):1063-70.
1983: M A Campbell; J Gyorkos; B Leece; K Homonko; Stephen Safe
The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes.
General pharmacology 1983;14(4):445-54.
1982: S Bandiera; T Sawyer; M A Campbell; L Robertson; Stephen Safe
Halogenated biphenyls as AHH inducers: effects of different halogen substituents.
Life sciences 1982;31(6):517-25.
1982: Stephen Safe; L W Robertson; L Safe; A Parkinson; S Bandiera; T Sawyer; M A Campbell
Halogenated biphenyls: molecular toxicology.
Canadian journal of physiology and pharmacology 1982;60(7):1057-64.
1982: S Bandiera; Stephen Safe; A B Okey
Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene- or mixed-type inducers to cytosolic Ah receptor.
Chemico-biological interactions 1982;39(3):259-77.
1981: A Parkinson; L W Robertson; L Safe; Stephen Safe
Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: effects of di-ortho substitution.
Chemico-biological interactions 1981;35(1):1-12.
1980: A Parkinson; L Robertson; L Safe; Stephen Safe
Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: structure-activity rules.
Chemico-biological interactions 1980;30(3):271-85.