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Stephen Safe

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Anatomy

Disorders

Breast Neoplasms

Physiology

Enzyme Induction

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Co-Publications
Name
31
Abdelrahim, Maen
25
Samudio, Ismael
24
Chintharlapalli, Sudhakar
19
Zacharewski, Timothy
18
Liu, Shengxi
18
Papineni, Sabitha
17
Wang, Fen
16
Burghardt, Robert
15
Wormke, Mark
14
Porter, Weston
12
Chen, I
11
Barhoumi, Rola
11
Gaido, Kevin
11
Smith, Roger
10
Qin, Chunhua

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Publications

TOP 3
Sreevalsan Sandeep; Jutooru Indira; Chadalapaka Gayathri; Walker Michael; Safe Stephen
1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells.
Chintharlapalli Sudhakar; Papineni Sabitha; Abdelrahim Maen; Abudayyeh Ala; Jutooru Indira; Chadalapaka Gayathri; Wu Fei; Mertens-Talcott Susanne; Vanderlaag Kathy; Cho Sung Dae; Smith Roger; Safe Stephen
Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells.
Zhang Shu; Lei Ping; Liu Xinyi; Li Xiangrong; Walker Kelcey; Kotha Leela; Rowlands Craig; Safe Stephen
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy.

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All Publications

2009: Sreevalsan Sandeep; Jutooru Indira; Chadalapaka Gayathri; Walker Michael; Safe Stephen
1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells.
International journal of oncology 2009;35(5):1191-9.
2009: Chintharlapalli Sudhakar; Papineni Sabitha; Abdelrahim Maen; Abudayyeh Ala; Jutooru Indira; Chadalapaka Gayathri; Wu Fei; Mertens-Talcott Susanne; Vanderlaag Kathy; Cho Sung Dae; Smith Roger; Safe Stephen
Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells.
International journal of cancer. Journal international du cancer 2009;125(8):1965-74.
2009: Zhang Shu; Lei Ping; Liu Xinyi; Li Xiangrong; Walker Kelcey; Kotha Leela; Rowlands Craig; Safe Stephen
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy.
Endocrine-related cancer 2009;16(3):835-44.
2009: Jutooru Indira; Chadalapaka Gayathri; Chintharlapalli Sudhakar; Papineni Sabitha; Safe Stephen
Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative.
Molecular carcinogenesis 2009;48(8):692-702.
2009: Lee Syng-Ook; Chintharlapalli Sudhakar; Liu Shengxi; Papineni Sabitha; Cho Sung Dae; Yoon Kyungsil; Safe Stephen
p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells.
Molecular cancer research : MCR 2009;7(7):1169-78.
2009: Papineni Sabitha; Chintharlapalli Sudhakar; Abdelrahim Maen; Lee Syng-ook; Burghardt Robert; Abudayyeh Ala; Baker Cheryl; Herrera Luis; Safe Stephen
Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met.
Carcinogenesis 2009;30(7):1193-201.
2009: Barhoumi Rola; Catania Jeffrey M; Parrish Alan R; Awooda Igbal; Tiffany-Castiglioni Evelyn; Safe Stephen; Burghardt Robert C
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines.
The Journal of toxicological sciences 2009;34(1):13-25.
2008: Safe Stephen; Kim Kyounghyun;
Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways.
Journal of molecular endocrinology 2008;41(5):263-75.
2008: Wu Fei; Xu Rui; Kim Kyounghyun; Martin James; Safe Stephen
In vivo profiling of estrogen receptor/specificity protein-dependent transactivation.
Endocrinology 2008;149(11):5696-705.
2008: Lei Ping; Abdelrahim Maen; Cho Sung Dae; Liu Xinyi; Safe Stephen
Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3'-indoly)-1-(p-substituted phenyl)methanes.
Molecular cancer therapeutics 2008;7(10):3363-72.
2008: Safe Stephen; Papineni Sabitha; Chintharlapalli Sudhakar
Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs.
Cancer letters 2008;269(2):326-38.
2008: Cho Sung Dae; Chintharlapalli Sudhakar; Abdelrahim Maen; Papineni Sabitha; Liu Shengxi; Guo Jingjing; Lei Ping; Abudayyeh Ala; Safe Stephen
5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells.
Molecular cancer therapeutics 2008;7(7):2109-20.
2008: Chadalapaka Gayathri; Jutooru Indira; Chintharlapalli Sudhakar; Papineni Sabitha; Smith Roger; Li Xiangrong; Safe Stephen
Curcumin decreases specificity protein expression in bladder cancer cells.
Cancer research 2008;68(13):5345-54.
2008: Hong Jun; Samudio Ismael; Chintharlapalli Sudhakar; Safe Stephen
1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines.
Molecular carcinogenesis 2008;47(7):492-507.
2008: Lei Ping; Abdelrahim Maen; Cho Sung Dae; Liu Shengxi; Chintharlapalli Sudhakar; Safe Stephen
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase.
Carcinogenesis 2008;29(6):1139-47.
2008: Pacheco-Palencia Lisbeth A; Talcott Stephen T; Safe Stephen; Mertens-Talcott Susanne
Absorption and biological activity of phytochemical-rich extracts from açai (Euterpe oleracea Mart.) pulp and oil in vitro.
Journal of agricultural and food chemistry 2008;56(10):3593-600.
2008: Wu Fei; Khan Shaheen; Wu Qian; Barhoumi Rola; Burghardt Robert; Safe Stephen
Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens.
The Journal of steroid biochemistry and molecular biology 2008;110(1-2):104-15.
2008: Vanderlaag Kathy; Su Yunpeng; Frankel Arthur E; Grage Henry; Smith Roger; Khan Shaheen; Safe Stephen
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways.
Breast cancer research and treatment 2008;109(2):273-83.
2008: Chadalapaka Gayathri; Jutooru Indira; McAlees Alan; Stefanac Tom; Safe Stephen
Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives.
Bioorganic & medicinal chemistry letters 2008;18(8):2633-9.
2008: Cho Sung Dae; Lei Ping; Abdelrahim Maen; Yoon Kyungsil; Liu Shengxi; Guo Jingjing; Papineni Sabitha; Chintharlapalli Sudhakar; Safe Stephen
1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells.
Molecular carcinogenesis 2008;47(4):252-63.
2008: Zhang Shu; Rowlands Craig; Safe Stephen
Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay.
Toxicology and applied pharmacology 2008;227(2):196-206.
2008: Tjalkens Ronald B; Liu Xuhong; Mohl Brianne; Wright Tyler; Moreno Julie A; Carbone David L; Safe Stephen
The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells.
Journal of neuroscience research 2008;86(3):618-29.
2008: Higgins Kelly J; Liu Shengxi; Abdelrahim Maen; Vanderlaag Kathryn; Liu Xinyi; Porter Weston; Metz Richard; Safe Stephen
Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins.
Molecular endocrinology (Baltimore, Md.) 2008;22(2):388-402.
2008: Papineni Sabitha; Chintharlapalli Sudhakar; Safe Stephen
Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells.
Molecular pharmacology 2008;73(2):553-65.
2007: Mertens-Talcott Susanne U; Chintharlapalli Sudhakar; Li Xiangrong; Safe Stephen
The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells.
Cancer research 2007;67(22):11001-11.
2007: York Melissa; Abdelrahim Maen; Chintharlapalli Sudhakar; Lucero Salina D; Safe Stephen
1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce apoptosis and inhibit renal cell carcinoma growth.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(22 Pt 1):6743-52.
2007: Chintharlapalli Sudhakar; Papineni Sabitha; Liu Shengxi; Jutooru Indira; Chadalapaka Gayathri; Cho Sung-dae; Murthy Rajesh S; You Youngjae; Safe Stephen
2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells.
Carcinogenesis 2007;28(11):2337-46.
2007: Khan Shaheen; Wu Fei; Liu Shengxi; Wu Qian; Safe Stephen
Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells.
Journal of molecular endocrinology 2007;39(4):289-304.
2007: Khan Shaheen; Liu Shengxi; Stoner Matthew; Safe Stephen
Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells.
Toxicology and applied pharmacology 2007;223(1):28-38.
2007: Chintharlapalli Sudhakar; Papineni Sabitha; Jutooru Indira; McAlees Alan; Safe Stephen
Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells.
Molecular cancer therapeutics 2007;6(5):1588-98.
2007: Lee Jeongeun; Safe Stephen
Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150).
Archives of biochemistry and biophysics 2007;461(2):200-10.
2007: Abdelrahim Maen; Baker Cheryl H; Abbruzzese James L; Sheikh-Hamad David; Liu Shengxi; Cho Sung Dae; Yoon Kyungsil; Safe Stephen
Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells.
Cancer research 2007;67(7):3286-94.
2007: Chintharlapalli Sudhakar; Papineni Sabitha; Ramaiah Shashi K; Safe Stephen
Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.
Cancer research 2007;67(6):2816-23.
2007: Chintharlapalli Sudhakar; Papineni Sabitha; Safe Stephen
1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in LNCaP prostate cancer cells through peroxisome proliferator-activated receptor gamma-independent pathways.
Molecular pharmacology 2007;71(2):558-69.
2007: Cho Sung Dae; Yoon Kyungsil; Chintharlapalli Sudhakar; Abdelrahim Maen; Lei Ping; Hamilton Stanley; Khan Shaheen; Ramaiah Shashi K; Safe Stephen
Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways.
Cancer research 2007;67(2):674-83.
2007: Wu Fei; Safe Stephen
Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2007;103(1):1-9.
2007: Su Yunpeng; Vanderlaag Kathryn; Ireland Courtney; Ortiz Janelle; Grage Henry; Safe Stephen; Frankel Arthur E
1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice.
Breast cancer research : BCR 2007;9(4):R56.
2006: Khan Shaheen; Konstantinov Alex; Chittim Brock; McAlees Alan; Yeo Brian; Safe Stephen
Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes.
Toxicology in vitro : an international journal published in association with BIBRA 2006;20(7):1234-7.
2006: Lei Ping; Abdelrahim Maen; Safe Stephen
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator-activated receptor-dependent and independent pathways.
Molecular cancer therapeutics 2006;5(9):2324-36.
2006: Liu Shengxi; Abdelrahim Maen; Khan Shaheen; Ariazi Eric; Jordan V Craig; Safe Stephen
Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells.
Biological chemistry 2006;387(9):1209-13.
2006: Khan Shaheen; Barhoumi Rola; Burghardt Robert; Liu Shengxi; Kim Kyounghyun; Safe Stephen
Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2006;20(9):2199-214.
2006: Ru Lee Wan; Chen Chien-Cheng; Liu Shengxi; Safe Stephen
17beta-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways.
Journal of cellular biochemistry 2006;99(1):209-20.
2006: Safe Stephen; Papineni Sabitha
The role of xenoestrogenic compounds in the development of breast cancer.
Trends in pharmacological sciences 2006;27(8):447-54.
2006: Barhoumi Rola; Awooda Igbal; Mouneimne Youssef; Safe Stephen; Burghardt Robert C
Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.
Toxicology letters 2006;165(2):133-41.
2006: Higgins Kelly J; Liu Shengxi; Abdelrahim Maen; Yoon Kyungsil; Vanderlaag Kathryn; Porter Weston; Metz Richard P; Safe Stephen
Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.
Endocrinology 2006;147(7):3285-95.
2006: Abdelrahim Maen; Baker Cheryl H; Abbruzzese James L; Safe Stephen
Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation.
Journal of the National Cancer Institute 2006;98(12):855-68.
2006: Higgins Kelly J; Abdelrahim Maen; Liu Shengxi; Yoon Kyungsil; Safe Stephen
Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins.
Biochemical and biophysical research communications 2006;345(1):292-301.
2006: Chintharlapalli Sudhakar; Papineni Sabitha; Safe Stephen
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways.
Molecular cancer therapeutics 2006;5(5):1362-70.
2006: Vanderlaag Kathy; Samudio Ismael; Burghardt Robert; Barhoumi Rola; Safe Stephen
Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM.
Cancer letters 2006;236(2):198-212.
2006: Abdelrahim Maen; Newman Kristen; Vanderlaag Kathy; Samudio Ismael; Safe Stephen
3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.
Carcinogenesis 2006;27(4):717-28.
2006: Abdelrahim Maen; Ariazi Eric; Kim Kyounghyun; Khan Shaheen; Barhoumi Rola; Burghardt Robert; Liu Shengxi; Hill Denise; Finnell Richard; Wlodarczyk Bogdan; Jordan V Craig; Safe Stephen
3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha.
Cancer research 2006;66(4):2459-67.
2006: Li Xiangrong; Zhang Shu; Safe Stephen
Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds.
The Journal of steroid biochemistry and molecular biology 2006;98(2-3):122-32.
2006: Kassouf Wassim; Chintharlapalli Sudhakar; Abdelrahim Maen; Nelkin Gina; Safe Stephen; Kamat Ashish M
Inhibition of bladder tumor growth by 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes: a new class of peroxisome proliferator-activated receptor gamma agonists.
Cancer research 2006;66(1):412-8.
2006: Mitchell Dianne C; Abdelrahim Maen; Weng Jinsheng; Stafford Lewis J; Safe Stephen; Bar-Eli Menashe; Liu Mingyao
Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1.
The Journal of biological chemistry 2006;281(1):51-8.
2005: Samudio Ismael; Konopleva Marina; Safe Stephen; McQueen Teresa; Andreeff Michael
Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure.
Molecular cancer therapeutics 2005;4(12):1982-92.
2005: Chintharlapalli Sudhakar; Papineni Sabitha; Baek Seung Joon; Liu Shengxi; Safe Stephen
1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1.
Molecular pharmacology 2005;68(6):1782-92.
2005: Safe Stephen; Abdelrahim Maen
Sp transcription factor family and its role in cancer.
European journal of cancer (Oxford, England : 1990) 2005;41(16):2438-48.
2005: Samudio Ismael; Konopleva Marina; Hail Numsen; Shi Yue-Xi; McQueen Teresa; Hsu Timothy; Evans Randall; Honda Tadashi; Gribble Gordon W; Sporn Michael; Gilbert Hiram F; Safe Stephen; Andreeff Michael
2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.
The Journal of biological chemistry 2005;280(43):36273-82.
2005: Abdelrahim Maen; Safe Stephen
Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins.
Molecular pharmacology 2005;68(2):317-29.
2005: Chintharlapalli Sudhakar; Burghardt Robert; Papineni Sabitha; Ramaiah Shashi; Yoon Kyungsil; Safe Stephen
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.
The Journal of biological chemistry 2005;280(26):24903-14.
2005: Chintharlapalli Sudhakar; Papineni Sabitha; Konopleva Marina; Andreef Michael; Samudio Ismael; Safe Stephen
2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways.
Molecular pharmacology 2005;68(1):119-28.
2005: Safe Stephen
Clinical correlates of environmental endocrine disruptors.
Trends in endocrinology and metabolism: TEM 2005;16(4):139-44.
2005: Abdelrahim Maen; Liu Shengxi; Safe Stephen
Induction of endoplasmic reticulum-induced stress genes in Panc-1 pancreatic cancer cells is dependent on Sp proteins.
The Journal of biological chemistry 2005;280(16):16508-13.
2005: Kim Kyounghyun; Barhoumi Rola; Burghardt Robert; Safe Stephen
Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer.
Molecular endocrinology (Baltimore, Md.) 2005;19(4):843-54.
2005: Lee Jeongeun Eun; Kim Kyounghyun; Sacchettini James C; Smith Clare V; Safe Stephen
DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.
The Journal of biological chemistry 2005;280(10):8819-30.
2004: Wu Qian; Burghardt Robert; Safe Stephen
Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins.
The Journal of biological chemistry 2004;279(51):53602-12.
2004: Safe Stephen
Endocrine disruptors and human health: is there a problem.
Toxicology 2004;205(1-2):3-10.
2004: Hong Jun; Samudio Ismael; Liu Shengxi; Abdelrahim Maen; Safe Stephen
Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins.
Endocrinology 2004;145(12):5774-85.
2004: Chen Chien-Cheng; Lee Wan-Ru; Safe Stephen
Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1.
Journal of cellular biochemistry 2004;93(5):1063-74.
2004: Abdelrahim Maen; Smith Roger; Burghardt Robert; Safe Stephen
Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells.
Cancer research 2004;64(18):6740-9.
2004: Chintharlapalli Sudhakar; Smith Roger; Samudio Ismael; Zhang Wei; Safe Stephen
1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor gamma-mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells.
Cancer research 2004;64(17):5994-6001.
2004: Li Xiangrong; Qin Chunhua; Burghardt Robert; Safe Stephen
Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells.
Biochemical and biophysical research communications 2004;320(3):625-34.
2004: Qin Chunhua; Samudio Ismael; Ngwenya Sharon; Safe Stephen
Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways.
Molecular carcinogenesis 2004;40(3):160-70.
2004: Pearce Sandra Timm; Liu Hong; Radhakrishnan Ishwar; Abdelrahim Maen; Safe Stephen; Jordan V Craig
Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8-trichlorodibenzofuran with estrogen receptor alpha.
Cancer research 2004;64(8):2889-97.
2004: Qin Chunhua; Morrow Derek; Stewart Jessica; Spencer Kyle; Porter Weston; Smith Roger; Phillips Timothy; Abdelrahim Maen; Samudio Ismael; Safe Stephen
A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes.
Molecular cancer therapeutics 2004;3(3):247-60.
2004: Stoner Matthew; Wormke Mark; Saville Brad; Samudio Ismael; Qin Chunhua; Abdelrahim Maen; Safe Stephen
Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins.
Oncogene 2004;23(5):1052-63.
2004: Morrow Derek; Qin Chunhua; Smith Roger; Safe Stephen
Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.
The Journal of steroid biochemistry and molecular biology 2004;88(1):27-36.
2004: Safe Stephen; Kim Kyounghyun
Nuclear receptor-mediated transactivation through interaction with Sp proteins.
Progress in nucleic acid research and molecular biology 2004;77():1-36.
2003: Safe Stephen; Wormke Mark
Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action.
Chemical research in toxicology 2003;16(7):807-16.
2003: Abdelrahim Maen; Smith Roger; Safe Stephen
Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells.
Molecular pharmacology 2003;63(6):1373-81.
2003: Khan Shaheen; Abdelrahim Maen; Samudio Ismael; Safe Stephen
Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells.
Endocrinology 2003;144(6):2325-35.
2003: Ngwenya Sharon; Safe Stephen
Cell context-dependent differences in the induction of E2F-1 gene expression by 17 beta-estradiol in MCF-7 and ZR-75 cells.
Endocrinology 2003;144(5):1675-85.
2003: Kim Kyounghyun; Thu Nguyen; Saville Brad; Safe Stephen
Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2003;17(5):804-17.
2003: Qin Chunhua; Burghardt Robert; Smith Roger; Wormke Mark; Stewart Jessica; Safe Stephen
Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.
Cancer research 2003;63(5):958-64.
2003: Wormke Mark; Stoner Matthew; Saville Bradley; Walker Kelcey; Abdelrahim Maen; Burghardt Robert; Safe Stephen
The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes.
Molecular and cellular biology 2003;23(6):1843-55.
2003: Castro-Rivera Emely; Safe Stephen
17 beta-estradiol- and 4-hydroxytamoxifen-induced transactivation in breast, endometrial and liver cancer cells is dependent on ER-subtype, cell and promoter context.
The Journal of steroid biochemistry and molecular biology 2003;84(1):23-31.
2002: Vyhlidal C; Li X; Safe S
Estrogen regulation of transferrin gene expression in MCF-7 human breast cancer cells.
Journal of molecular endocrinology 2002;29(3):305-17.
2002: Safe Stephen
Environmental estrogens: roles in male reproductive tract problems and in breast cancer.
Reviews on environmental health 2002;17(4):253-62.
2002: Stoner Matthew; Saville Bradley; Wormke Mark; Dean Dana; Burghardt Robert; Safe Stephen
Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2002;16(10):2231-42.
2002: Qin Chunhua; Nguyen Thu; Stewart Jessica; Samudio Ismael; Burghardt Robert; Safe Stephen
Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex.
Molecular endocrinology (Baltimore, Md.) 2002;16(8):1793-809.
2002: Abdelrahim Maen; Samudio Ismael; Smith Roger; Burghardt Robert; Safe Stephen
Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells.
The Journal of biological chemistry 2002;277(32):28815-22.
2002: Duan Renqin; Xie Wen; Li Xiangrong; McDougal Andrew; Safe Stephen
Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells.
Biochemical and biophysical research communications 2002;294(2):384-94.
2002: Safe Stephen; McDougal Andrew
Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review).
International journal of oncology 2002;20(6):1123-8.
2002: Mealey Katrina L; Barhoumi Rola; Burghardt Robert C; Safe Stephen; Kochevar Deborah T
Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells.
Antimicrobial agents and chemotherapy 2002;46(3):755-61.
2002: Saville Bradley; Poukka Hetti; Wormke Mark; Janne Olli A; Palvimo Jorma J; Stoner Matthew; Samudio Ismael; Safe Stephen
Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein.
The Journal of biological chemistry 2002;277(4):2485-97.
2001: Lee J E; Safe S
Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells.
Biochemical pharmacology 2001;62(8):1113-24.
2001: Castro-Rivera E; Samudio I; Safe S
Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements.
The Journal of biological chemistry 2001;276(33):30853-61.
2001: Yoon K; Pallaroni L; Stoner M; Gaido K; Safe S
Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements.
The Journal of steroid biochemistry and molecular biology 2001;78(1):25-32.
2001: Xie W; Duan R; Safe S
Activation of adenosine deaminase in MCF-7 cells through IGF-estrogen receptor alpha crosstalk.
Journal of molecular endocrinology 2001;26(3):217-28.
2001: McDougal A; Wormke M; Calvin J; Safe S
Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator.
Cancer research 2001;61(10):3902-7.
2001: Qin C; Wilson C; Blancher C; Taylor M; Safe S; Harris A L
Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):818-23.
2001: Duan R; Xie W; Burghardt R C; Safe S
Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1.
The Journal of biological chemistry 2001;276(15):11590-8.
2001: Safe S
Molecular biology of the Ah receptor and its role in carcinogenesis.
Toxicology letters 2001;120(1-3):1-7.
2001: Samudio I; Vyhlidal C; Wang F; Stoner M; Chen I; Kladde M; Barhoumi R; Burghardt R; Safe S
Transcriptional activation of deoxyribonucleic acid polymerase alpha gene expression in MCF-7 cells by 17 beta-estradiol.
Endocrinology 2001;142(3):1000-8.
2001: Porter W; Wang F; Duan R; Qin C; Castro-Rivera E; Kim K; Safe S
Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists.
Journal of molecular endocrinology 2001;26(1):31-42.
2001: Wang F; Samudio I; Safe S
Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.
Molecular and cellular endocrinology 2001;172(1-2):91-103.
2001: Chen I; Hsieh T; Thomas T; Safe S
Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization.
Gene 2001;262(1-2):207-14.
2001: Wang F; Samudio I; Safe S
Transcriptional activation of rat creatine kinase B by 17beta-estradiol in MCF-7 cells involves an estrogen responsive element and GC-rich sites.
Journal of cellular biochemistry 2001;84(1):156-72.
2001: Safe S
Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions.
Vitamins and hormones 2001;62():231-52.
2000: Lee J E; Safe S
3',4'-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells.
Toxicological sciences : an official journal of the Society of Toxicology 2000;58(2):235-42.
2000: Gaido K W; Maness S C; McDonnell D P; Dehal S S; Kupfer D; Safe S
Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies.
Molecular pharmacology 2000;58(4):852-8.
2000: Safe S
Bisphenol A and related endocrine disruptors.
Toxicological sciences : an official journal of the Society of Toxicology 2000;56(2):251-2.
2000: Safe S; Wormke M; Samudio I
Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells.
Journal of mammary gland biology and neoplasia 2000;5(3):295-306.
2000: Wormke M; Stoner M; Saville B; Safe S
Crosstalk between estrogen receptor alpha and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes.
FEBS letters 2000;478(1-2):109-12.
2000: Xie W; Duan R; Chen I; Samudio I; Safe S
Transcriptional activation of thymidylate synthase by 17beta-estradiol in MCF-7 human breast cancer cells.
Endocrinology 2000;141(7):2439-49.
2000: Stoner M; Wang F; Wormke M; Nguyen T; Samudio I; Vyhlidal C; Marme D; Finkenzeller G; Safe S
Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins.
The Journal of biological chemistry 2000;275(30):22769-79.
2000: Vyhlidal C; Samudio I; Kladde M P; Safe S
Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-site.
Journal of molecular endocrinology 2000;24(3):329-38.
2000: Yoon K; Pellaroni L; Ramamoorthy K; Gaido K; Safe S
Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines.
Molecular and cellular endocrinology 2000;162(1-2):211-20.
2000: Wormke M; Castro-Rivera E; Chen I; Safe S
Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells.
The Journal of steroid biochemistry and molecular biology 2000;72(5):197-207.
2000: Saville B; Wormke M; Wang F; Nguyen T; Enmark E; Kuiper G; Gustafsson J A; Safe S
Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements.
The Journal of biological chemistry 2000;275(8):5379-87.
1999: Gaido K W; Leonard L S; Maness S C; Hall J M; McDonnell D P; Saville B; Safe S
Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta.
Endocrinology 1999;140(12):5746-53.
1999: Safe S; Wargovich M J; Lamartiniere C A; Mukhtar H
Symposium on mechanisms of action of naturally occurring anticarcinogens.
Toxicological sciences : an official journal of the Society of Toxicology 1999;52(1):1-8.
1999: Dong L; Wang W; Wang F; Stoner M; Reed J C; Harigai M; Samudio I; Kladde M P; Vyhlidal C; Safe S
Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells.
The Journal of biological chemistry 1999;274(45):32099-107.
1999: Safe S; Qin C; McDougal A
Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer.
Expert opinion on investigational drugs 1999;8(9):1385-96.
1999: Duan R; Porter W; Samudio I; Vyhlidal C; Kladde M; Safe S
Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.
Molecular endocrinology (Baltimore, Md.) 1999;13(9):1511-21.
1999: Wang F; Wang W; Safe S
Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl hydrocarbon receptor complex.
Biochemistry 1999;38(35):11490-500.
1999: Wang W; Dong L; Saville B; Safe S
Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions.
Molecular endocrinology (Baltimore, Md.) 1999;13(8):1373-87.
1999: Nguyen T A; Hoivik D; Lee J E; Safe S
Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex.
Archives of biochemistry and biophysics 1999;367(2):250-7.
1999: Qin C; Singh P; Safe S
Transcriptional activation of insulin-like growth factor-binding protein-4 by 17beta-estradiol in MCF-7 cells: role of estrogen receptor-Sp1 complexes.
Endocrinology 1999;140(6):2501-8.
1999: Castro-Rivera E; Wormke M; Safe S
Estrogen and aryl hydrocarbon responsiveness of ECC-1 endometrial cancer cells.
Molecular and cellular endocrinology 1999;150(1-2):11-21.
1999: Xie W; Duan R; Safe S
Estrogen induces adenosine deaminase gene expression in MCF-7 human breast cancer cells: role of estrogen receptor-Sp1 interactions.
Endocrinology 1999;140(1):219-27.
1998: Gupta M; McDougal A; Safe S
Estrogenic and antiestrogenic activities of 16alpha- and 2-hydroxy metabolites of 17beta-estradiol in MCF-7 and T47D human breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1998;67(5-6):413-9.
1998: Safe S; Connor K; Gaido K
Methods for xenoestrogen testing.
Toxicology letters 1998;102-103():665-70.
1998: Safe S; Wang F; Porter W; Duan R; McDougal A
Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms.
Toxicology letters 1998;102-103():343-7.
1998: Gaido K; Dohme L; Wang F; Chen I; Blankvoort B; Ramamoorthy K; Safe S
Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food.
Environmental health perspectives 1998;106 Suppl 6():1347-51.
1998: Goldstein L S; Weyand E H; Safe S; Steinberg M; Culp S J; Gaylor D W; Beland F A; Rodriguez L V
Tumors and DNA adducts in mice exposed to benzo[a]pyrene and coal tars: implications for risk assessment.
Environmental health perspectives 1998;106 Suppl 6():1325-30.
1998: Wilson C L; Safe S
Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses.
Toxicologic pathology 1998;26(5):657-71.
1998: Chen I; McDougal A; Wang F; Safe S
Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane.
Carcinogenesis 1998;19(9):1631-9.
1998: Wang W; Smith R; Safe S
Aryl hydrocarbon receptor-mediated antiestrogenicity in MCF-7 cells: modulation of hormone-induced cell cycle enzymes.
Archives of biochemistry and biophysics 1998;356(2):239-48.
1998: Gould J C; Leonard L S; Maness S C; Wagner B L; Conner K; Zacharewski T; Safe S; McDonnell D P; Gaido K W
Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.
Molecular and cellular endocrinology 1998;142(1-2):203-14.
1998: Sun G; Porter W; Safe S
Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex.
Molecular endocrinology (Baltimore, Md.) 1998;12(6):882-90.
1998: Wang F; Hoivik D; Pollenz R; Safe S
Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes.
Nucleic acids research 1998;26(12):3044-52.
1998: Duan R; Porter W; Safe S
Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation.
Endocrinology 1998;139(4):1981-90.
1998: McDougal A; Safe S
Induction of 16alpha-/2-hydroxyestrone metabolite ratios in MCF-7 cells by pesticides, carcinogens, and antiestrogens does not predict mammary carcinogens.
Environmental health perspectives 1998;106(4):203-6.
1998: Castro-Rivera E; Safe S
Estrogen- and antiestrogen-responsiveness of HEC1A endometrial adenocarcinoma cells in culture.
The Journal of steroid biochemistry and molecular biology 1998;64(5-6):287-95.
1997: Hoivik D; Wilson C; Wang W; Willett K; Barhoumi R; Burghardt R; Safe S
Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells.
Archives of biochemistry and biophysics 1997;348(1):174-82.
1997: McDougal A; Wilson C; Safe S
Inhibition of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor growth by aryl hydrocarbon receptor agonists.
Cancer letters 1997;120(1):53-63.
1997: Hoivik D; Willett K; Wilson C; Safe S
Estrogen does not inhibit 2,3,7, 8-tetrachlorodibenzo-p-dioxin-mediated effects in MCF-7 and Hepa 1c1c7 cells.
The Journal of biological chemistry 1997;272(48):30270-4.
1997: Ramamoorthy K; Vyhlidal C; Wang F; Chen I; Safe S; McDonnell D P; Leonard L S; Gaido K W
Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol.
Toxicology and applied pharmacology 1997;147(1):93-100.
1997: Porter W; Saville B; Hoivik D; Safe S
Functional synergy between the transcription factor Sp1 and the estrogen receptor.
Molecular endocrinology (Baltimore, Md.) 1997;11(11):1569-80.
1997: Safe S; Connor K; Ramamoorthy K; Gaido K; Maness S
Human exposure to endocrine-active chemicals: hazard assessment problems.
Regulatory toxicology and pharmacology : RTP 1997;26(1 Pt 1):52-8.
1997: Connor K; Ramamoorthy K; Moore M; Mustain M; Chen I; Safe S; Zacharewski T; Gillesby B; Joyeux A; Balaguer P
Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships.
Toxicology and applied pharmacology 1997;145(1):111-23.
1997: Wang F; Porter W; Xing W; Archer T K; Safe S
Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene.
Biochemistry 1997;36(25):7793-801.
1997: Ramamoorthy K; Wang F; Chen I C; Norris J D; McDonnell D P; Leonard L S; Gaido K W; Bocchinfuso W P; Korach K S; Safe S
Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism.
Endocrinology 1997;138(4):1520-7.
1997: Nodland K I; Wormke M; Safe S
Inhibition of estrogen-induced activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-7 human breast cancer and other cell lines transfected with vitellogenin A2 gene promoter constructs.
Archives of biochemistry and biophysics 1997;338(1):67-72.
1997: Rodriguez L V; Dunsford H A; Steinberg M; Chaloupka K K; Zhu L; Safe S; Womack J E; Goldstein L S
Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice.
Carcinogenesis 1997;18(1):127-35.
1997: Moore M; Mustain M; Daniel K; Chen I; Safe S; Zacharewski T; Gillesby B; Joyeux A; Balaguer P
Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum.
Toxicology and applied pharmacology 1997;142(1):160-8.
1997: Ramamoorthy K; Wang F; Chen I C; Safe S; Norris J D; McDonnell D P; Gaido K W; Bocchinfuso W P; Korach K S
Potency of combined estrogenic pesticides.
Science (New York, N.Y.) 1997;275(5298):405-6.
1997: Safe S
Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds.
Teratogenesis, carcinogenesis, and mutagenesis 1997;17(4-5):285-304.
1997: Sun G; Safe S
Antiestrogenic activities of alternate-substituted polychlorinated dibenzofurans in MCF-7 human breast cancer cells.
Cancer chemotherapy and pharmacology 1997;40(3):239-44.
1996: Porter W; Wang F; Wang W; Duan R; Safe S
Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression.
Molecular endocrinology (Baltimore, Md.) 1996;10(11):1371-8.
1996: Wilker C; Johnson L; Safe S
Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring.
Toxicology and applied pharmacology 1996;141(1):68-75.
1996: Lu Y F; Sun G; Wang X; Safe S
Inhibition of prolactin receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 human breast cancer cells.
Archives of biochemistry and biophysics 1996;332(1):35-40.
1996: Liu H; Safe S
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on insulin-induced responses in MCF-7 human breast cancer cells.
Toxicology and applied pharmacology 1996;138(2):242-50.
1996: Santostefano M; Safe S
Characterization of the molecular and structural properties of the transformed and nuclear aryl hydrocarbon (Ah) receptor complexes by proteolytic digestion.
Chemico-biological interactions 1996;100(3):221-40.
1996: Harper N; Steinberg M; Safe S
Immunotoxicity of a reconstituted polynuclear aromatic hydrocarbon mixture in B6C3F1 mice.
Toxicology 1996;109(1):31-8.
1996: Lu Y F; Santostefano M; Cunningham B D; Threadgill M D; Safe S
Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists.
Biochemical pharmacology 1996;51(8):1077-87.
1996: Chen I; Safe S; Bjeldanes L
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells.
Biochemical pharmacology 1996;51(8):1069-76.
1996: Connor K; Howell J; Chen I; Liu H; Berhane K; Sciarretta C; Safe S; Zacharewski T
Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;30(1):93-101.
1996: Moore M; Ruh M; Steinberg M; Safe S
Isolation and characterization of variant benzo[a]pyrene-resistant T47D human breast-cancer cells.
International journal of cancer. Journal international du cancer 1996;66(1):117-23.
1996: Wang W L; Thomsen J S; Porter W; Moore M; Safe S
Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells.
British journal of cancer 1996;73(3):316-22.
1995: Safe S; Krishnan V
Chlorinated hydrocarbons: estrogens and antiestrogens.
Toxicology letters 1995;82-83():731-6.
1995: Dickerson R; Keller L H; Safe S
Alkyl polychlorinated dibenzofurans and related compounds as antiestrogens in the female rat uterus: structure-activity studies.
Toxicology and applied pharmacology 1995;135(2):287-98.
1995: Krishnan V; Porter W; Santostefano M; Wang X; Safe S
Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells.
Molecular and cellular biology 1995;15(12):6710-9.
1995: Connor K; Safe S; Jefcoate C R; Larsen M
Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats.
Biochemical pharmacology 1995;50(11):1913-20.
1995: Wang X; Thomsen J S; Santostefano M; Rosengren R; Safe S; Perdew G H
Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines.
European journal of pharmacology 1995;293(3):191-205.
1995: Ruh M F; Zacharewski T; Connor K; Howell J; Chen I; Safe S
Naringenin: a weakly estrogenic bioflavonoid that exhibits antiestrogenic activity.
Biochemical pharmacology 1995;50(9):1485-93.
1995: Merchant M; Safe S
In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by alpha-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct.
Biochemical pharmacology 1995;50(5):663-8.
1995: Harper N; Connor K; Steinberg M; Safe S
Immunosuppressive activity of polychlorinated biphenyl mixtures and congeners: nonadditive (antagonistic) interactions.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1995;27(1):131-9.
1995: Chaloupka K; Steinberg M; Santostefano M; Rodriguez L V; Goldstein L; Safe S
Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice.
Chemico-biological interactions 1995;96(3):207-21.
1995: Harper N; Steinberg M; Thomsen J; Safe S
Halogenated aromatic hydrocarbon-induced suppression of the plaque-forming cell response in B6C3F1 splenocytes cultured with allogenic mouse serum: Ah receptor structure activity relationships.
Toxicology 1995;99(3):199-206.
1995: Lu Y F; Santostefano M; Cunningham B D; Threadgill M D; Safe S
Identification of 3'-methoxy-4'-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells.
Archives of biochemistry and biophysics 1995;316(1):470-7.
1995: Safe S; Krishnan V
Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1995;17():99-115.
1994: Chaloupka K; Santostefano M; Goldfarb I S; Liu G; Myers M J; Tsyrolv I B; Gelboin H V; Krishnan V; Safe S
Aryl hydrocarbon (Ah) receptor-independent induction of Cyp1a2 gene expression by acenaphthylene and related compounds in B6C3F1 mice.
Carcinogenesis 1994;15(12):2835-40.
1994: Wang X; Safe S
Development of an in vitro model for investigating the formation of the nuclear Ah receptor complex in mouse Hepa 1c1c7 cells.
Archives of biochemistry and biophysics 1994;315(2):285-92.
1994: Narasimhan T R; Craig A; Arellano L; Harper N; Howie L; Menache M; Birnbaum L; Safe S
Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1994;23(4):598-607.
1994: Liu H; Santostefano M; Safe S
2-Phenylphenanthridinone and related compounds: aryl hydrocarbon receptor agonists and suicide inactivators of P4501A1.
Archives of biochemistry and biophysics 1994;313(2):206-14.
1994: Harper N; Connor K; Steinberg M; Safe S
An enzyme-linked immunosorbent assay (ELISA) specific for antibodies to TNP-LPS detects alterations in serum immunoglobulins and isotype switching in C57BL/6 and DBA/2 mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.
Toxicology 1994;92(1-3):155-67.
1994: Harper N; Wang X; Liu H; Safe S
Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists.
Molecular and cellular endocrinology 1994;104(1):47-55.
1994: Lu Y; Wang X; Safe S
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid in MCF-7 human breast cancer cells.
Toxicology and applied pharmacology 1994;127(1):1-8.
1994: Holcomb M; Safe S
Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Cancer letters 1994;82(1):43-7.
1994: Santosfefano M; Liu H; Wang X; Chaloupka K; Safe S
Effect of ligand structure on formation and DNA binding properties of the transformed rat cytosolic aryl hydrocarbon receptor.
Chemical research in toxicology 1994;7(4):544-50.
1994: Krishnan V; Wang X; Safe S
Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.
The Journal of biological chemistry 1994;269(22):15912-7.
1994: Thomsen J S; Wang X; Hines R N; Safe S
Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor.
Carcinogenesis 1994;15(5):933-7.
1994: Moore M; Wang X; Lu Y F; Wormke M; Craig A; Gerlach J H; Burghardt R; Barhoumi R; Safe S
Benzo[a]pyrene-resistant MCF-7 human breast cancer cells. A unique aryl hydrocarbon-nonresponsive clone.
The Journal of biological chemistry 1994;269(16):11751-9.
1994: Fernandez P; Burghardt R; Smith R; Nodland K; Safe S
High passage T47D human breast cancer cells: altered endocrine and 2,3,7,8-tetrachlorodibenzo-p-dioxin responsiveness.
European journal of pharmacology 1994;270(1):53-65.
1993: Harper N; Howie L; Connor K; Dickerson R; Safe S
Immunosuppressive effects of highly chlorinated biphenyls and diphenyl ethers on T-cell dependent and independent antigens in mice.
Toxicology 1993;85(2-3):123-35.
1993: Chaloupka K; Harper N; Krishnan V; Santostefano M; Rodriguez L V; Safe S
Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists.
Chemico-biological interactions 1993;89(2-3):141-58.
1993: Wang X; Porter W; Krishnan V; Narasimhan T R; Safe S
Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells.
Molecular and cellular endocrinology 1993;96(1-2):159-66.
1993: Liu H; Santostefano M; Lu Y; Safe S
6-substituted 3,4-benzocoumarins: a new structural class of inducers and inhibitors of CYP1A1-dependent activity.
Archives of biochemistry and biophysics 1993;306(1):223-31.
1993: Safe S
Development of bioassays and approaches for the risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.
Environmental health perspectives 1993;101 Suppl 3():317-25.
1993: Moore M; Narasimhan T R; Steinberg M A; Wang X; Safe S
Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate.
Archives of biochemistry and biophysics 1993;305(2):483-8.
1993: Merchant M; Krishnan V; Safe S
Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells.
Toxicology and applied pharmacology 1993;120(2):179-85.
1993: Harper N; Connor K; Safe S
Immunotoxic potencies of polychlorinated biphenyl (PCB), dibenzofuran (PCDF) and dibenzo-p-dioxin (PCDD) congeners in C57BL/6 and DBA/2 mice.
Toxicology 1993;80(2-3):217-27.
1993: Harper N; Howie L; Connor K; Arellano L; Craig A; Dickerson R; Safe S
Immunosuppressive and monooxygenase induction activities of highly chlorinated diphenyl ether congeners in C57BL/6 and DBA/2 mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;20(4):496-502.
1993: Harris M; Zacharewski T; Safe S
Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats--assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs).
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;20(4):456-63.
1993: Krishnan V; Safe S
Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships.
Toxicology and applied pharmacology 1993;120(1):55-61.
1993: Rowlands C; Krishnan V; Wang X; Santostefano M; Safe S; Miller W R; Langdon S
Characterization of the aryl hydrocarbon receptor and aryl hydrocarbon responsiveness in human ovarian carcinoma cell lines.
Cancer research 1993;53(8):1802-7.
1993: Safe S
Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems.
Environmental health perspectives 1993;100():259-68.
1993: Moore M; Narasimhan T R; Wang X; Krishnan V; Safe S; Williams H J; Scott A I
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1993;44(3):251-61.
1993: Arellano L O; Wang X; Safe S
Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines.
Carcinogenesis 1993;14(2):219-22.
1993: Santostefano M; Merchant M; Arellano L; Morrison V; Denison M S; Safe S
alpha-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation.
Molecular pharmacology 1993;43(2):200-6.
1993: Mayura K; Spainhour C B; Howie L; Safe S; Phillips T D
Teratogenicity and immunotoxicity of 3,3',4,4',5-pentachlorobiphenyl in C57BL/6 mice.
Toxicology 1993;77(1-2):123-31.
1992: Chaloupka K; Krishnan V; Safe S
Polynuclear aromatic hydrocarbon carcinogens as antiestrogens in MCF-7 human breast cancer cells: role of the Ah receptor.
Carcinogenesis 1992;13(12):2233-9.
1992: Wang X; Santostefano M; Lu Y; Safe S
A comparison of the mouse versus human aryl hydrocarbon (Ah) receptor complex: effects of proteolysis.
Chemico-biological interactions 1992;85(1):79-93.
1992: Merchant M; Morrison V; Santostefano M; Safe S
Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
Archives of biochemistry and biophysics 1992;298(2):389-94.
1992: Liu H; Biegel L; Narasimhan T R; Rowlands C; Safe S
Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.
Molecular and cellular endocrinology 1992;87(1-3):19-28.
1992: Santostefano M; Piskorska-Pliszczynska J; Morrison V; Safe S
Effects of ligand structure on the in vitro transformation of the rat cytosolic aryl hydrocarbon receptor.
Archives of biochemistry and biophysics 1992;297(1):73-9.
1992: Krishnan V; Narasimhan T; Safe S
Development of gel staining techniques for detecting the secretion of procathepsin D (52-kDa protein) in MCF-7 human breast cancer cells.
Analytical biochemistry 1992;204(1):137-42.
1992: Fernandez P; Safe S
Growth inhibitory and antimitogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in T47D human breast cancer cells.
Toxicology letters 1992;61(2-3):185-97.
1992: Rosengren R; Safe S; Bunce N J
Kinetics of the association of several tritiated polychlorinated dibenzo-p-dioxin and dibenzofuran congeners with hepatic cytosolic Ah receptor from the Wistar rat.
Chemical research in toxicology 1992;5(3):376-82.
1992: Wang X; Rosengren R; Morrison V; Santostefano M; Safe S
Characterization of the aryl hydrocarbon receptor in the human C-4II cervical squamous carcinoma cell line.
Biochemical pharmacology 1992;43(7):1635-42.
1992: Zacharewski T; Harris M; Biegel L; Morrison V; Merchant M; Safe S
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor.
Toxicology and applied pharmacology 1992;113(2):311-8.
1992: Dickerson R; Howie L; Safe S
The effect of 6-nitro-1,3,8-trichlorodibenzofuran as a partial estrogen in the female rat uterus.
Toxicology and applied pharmacology 1992;113(1):55-63.
1992: Merchant M; Wang X; Kamps C; Rosengren R; Morrison V; Safe S
Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: role of the nuclear 6 s and 4 s proteins.
Archives of biochemistry and biophysics 1992;292(1):250-7.
1991: Safe S; Astroff B; Harris M; Zacharewski T; Dickerson R; Romkes M; Biegel L
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action.
Pharmacology & toxicology 1991;69(6):400-9.
1991: Narasimhan T R; Safe S; Williams H J; Scott A I
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced glucose metabolism in MCF-7 human breast cancer cells: 13C nuclear magnetic resonance spectroscopy studies.
Molecular pharmacology 1991;40(6):1029-35.
1991: Piskorska-Pliszczynska J; Morrison V; Zacharewski T; Safe S
DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells.
Archives of biochemistry and biophysics 1991;290(2):362-8.
1991: Zacharewski T; Harris M; Safe S
Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse Hepa 1c1c7 cells.
Biochemical pharmacology 1991;41(12):1931-9.
1991: Astroff B; Eldridge B; Safe S
Inhibition of the 17 beta-estradiol-induced and constitutive expression of the cellular protooncogene c-fos by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the female rat uterus.
Toxicology letters 1991;56(3):305-15.
1991: Wang X; Narasimhan T R; Morrison V; Safe S
In situ and in vitro photoaffinity labeling of the nuclear aryl hydrocarbon receptor from transformed rodent and human cell lines.
Archives of biochemistry and biophysics 1991;287(1):186-94.
1991: Piskorska-Pliszczynska J; Astroff B; Zacharewski T; Harris M; Rosengren R; Morrison V; Safe L; Safe S
Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes.
Archives of biochemistry and biophysics 1991;284(1):193-200.
1991: Astroff B; Safe S
6-Alkyl-1,3,8-trichlorodibenzofurans as antiestrogens in female Sprague-Dawley rats.
Toxicology 1991;69(2):187-97.
1991: Safe S; Harris M; Zacharewski T
Development and validation of bioassays for polychlorinated dibenzo-p-dioxins and dibenzofurans.
IARC scientific publications 1991;(108):147-59.
1990: Biegel L; Safe S
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cell growth and the secretion of the estrogen-induced 34-, 52- and 160-kDa proteins in human breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1990;37(5):725-32.
1990: Astroff B; Rowlands C; Dickerson R; Safe S
2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17 beta-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression.
Molecular and cellular endocrinology 1990;72(3):247-52.
1990: Harris M; Zacharewski T; Piskorska-Pliszczynska J; Rosengren R; Safe S
Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: mechanistic studies.
Toxicology and applied pharmacology 1990;105(2):243-53.
1990: Howie L; Dickerson R; Davis D; Safe S
Immunosuppressive and monooxygenase induction activities of polychlorinated diphenyl ether congeners in C57BL/6N mice: quantitative structure-activity relationships.
Toxicology and applied pharmacology 1990;105(2):254-63.
1990: Dickerson R; Howie L; Davis D; Safe S
The structure-dependent effects of heptachlorodibenzofuran isomers in male C57BL/6 mice: immunotoxicity and monooxygenase enzyme induction.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1990;15(2):298-307.
1990: Merchant M; Arellano L; Safe S
The mechanism of action of alpha-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
Archives of biochemistry and biophysics 1990;281(1):84-9.
1990: Davis D; Safe S
Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: structure-activity relationships as Ah receptor agonists and partial antagonists.
Toxicology 1990;63(1):97-111.
1990: Kelley M; Womack J; Safe S
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins.
Biochemical pharmacology 1990;39(12):1991-8.
1990: Harris M; Zacharewski T; Safe S
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells.
Cancer research 1990;50(12):3579-84.
1990: Astroff B; Safe S
2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiestrogen: effect on rat uterine peroxidase activity.
Biochemical pharmacology 1990;39(3):485-8.
1990: Safe S
Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).
Critical reviews in toxicology 1990;21(1):51-88.
1989: Astroff B; Safe S
6-substituted-1,3,8-trichlorodibenzofurans as 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists in the rat: structure activity relationships.
Toxicology 1989;59(3):285-96.
1989: Landers J P; Piskorska-Pliszczynska J; Zacharewski T; Bunce N J; Safe S
Photoaffinity labeling of the nuclear Ah receptor from mouse Hepa 1c1c7 cells using 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.
The Journal of biological chemistry 1989;264(31):18463-71.
1989: Safe S; Mason G; Sawyer T; Zacharewski T; Harris M; Yao C; Keys B; Farrell K; Holcomb M; Davis D
Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review.
Toxicology and industrial health 1989;5(5):757-75.
1989: Yao C; Safe S
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies.
Toxicology and applied pharmacology 1989;100(2):208-16.
1989: Zacharewski T; Harris M; Safe S
Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners.
Archives of biochemistry and biophysics 1989;272(2):344-55.
1989: Harris M; Piskorska-Pliszczynska J; Zacharewski T; Romkes M; Safe S
Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor.
Cancer research 1989;49(16):4531-5.
1989: Harris M; Zacharewski T; Astroff B; Safe S
Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies.
Molecular pharmacology 1989;35(5):729-35.
1989: Biegel L; Harris M; Davis D; Rosengren R; Safe L; Safe S
2,2',4,4',5,5'-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice.
Toxicology and applied pharmacology 1989;97(3):561-71.
1989: Bannister R; Biegel L; Davis D; Astroff B; Safe S
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice.
Toxicology 1989;54(2):139-50.
1989: Makary M; Kim H L; Safe S; Womack J; Ivie G W
Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1989;92(2):171-4.
1988: Piskorska-Pliszczynska J; Safe S
Radioligand-dependent differences in the molecular properties of the mouse and rat hepatic aryl hydrocarbon receptor complexes.
Archives of biochemistry and biophysics 1988;267(1):372-83.
1988: Zacharewski T; Harris M; Safe S; Thoma H; Hutzinger O
Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining "2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents": pyrolyzed brominated flame retardants.
Toxicology 1988;51(2-3):177-89.
1988: Astroff B; Safe S
Comparative antiestrogenic activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in the female rat.
Toxicology and applied pharmacology 1988;95(3):435-43.
1988: Harris M; Kamps C; Safe S
Role of the 4-5S binding protein in the induction of aryl hydrocarbon hydroxylase in the rat.
Carcinogenesis 1988;9(8):1475-9.
1988: Davis D; Safe S
Immunosuppressive activities of polychlorinated dibenzofuran congeners: quantitative structure-activity relationships and interactive effects.
Toxicology and applied pharmacology 1988;94(1):141-9.
1988: Holcomb M; Yao C; Safe S
Biologic and toxic effects of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in the guinea pig. Quantitative structure-activity relationships.
Biochemical pharmacology 1988;37(8):1535-9.
1988: Romkes M; Safe S
Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus.
Toxicology and applied pharmacology 1988;92(3):368-80.
1988: Astroff B; Zacharewski T; Safe S; Arlotto M P; Parkinson A; Thomas P; Levin W
6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.
Molecular pharmacology 1988;33(2):231-6.
1988: Donnelly K C; Brown K W; Estiri M; Jones D H; Safe S
Mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p-dioxins and related compounds.
Journal of toxicology and environmental health 1988;24(3):345-56.
1988: Merrill J C; Kim H L; Safe S; Murray C A; Hayes M A
Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin.
Journal of toxicology and environmental health 1988;23(2):159-69.
1988: Makary M; Kim H L; Safe S; Womack J; Ivie G W
Constitutive and Aroclor 1254-induced hepatic glutathione S-transferase, peroxidase and reductase activities in genetically inbred mice.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1988;91(2):425-9.
1987: Farrell K; Safe L; Safe S
Synthesis and aryl hydrocarbon receptor binding properties of radiolabeled polychlorinated dibenzofuran congeners.
Archives of biochemistry and biophysics 1987;259(1):185-95.
1987: Romkes M; Piskorska-Pliszczynska J; Keys B; Safe S; Fujita T
Quantitative structure-activity relationships: analysis of interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2-substituted analogues with rat, mouse, guinea pig, and hamster cytosolic receptor.
Cancer research 1987;47(19):5108-11.
1987: Haake J M; Safe S; Mayura K; Phillips T D
Aroclor 1254 as an antagonist of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicology letters 1987;38(3):299-306.
1987: Leece B; Denomme M A; Towner R; Li A; Landers J; Safe S
Nonadditive interactive effects of polychlorinated biphenyl congeners in rats: role of the 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor.
Canadian journal of physiology and pharmacology 1987;65(9):1908-12.
1987: Mason G; Zacharewski T; Denomme M A; Safe L; Safe S
Polybrominated dibenzo-p-dioxins and related compounds: quantitative in vivo and in vitro structure-activity relationships.
Toxicology 1987;44(3):245-55.
1987: Farrell K; Safe S
Absence of positive co-operativity in the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to its cytosolic receptor protein.
The Biochemical journal 1987;244(3):539-46.
1987: Romkes M; Piskorska-Pliszczynska J; Safe S
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats.
Toxicology and applied pharmacology 1987;87(2):306-14.
1986: Piskorska-Pliszczynska J; Keys B; Safe S; Newman M S
The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons.
Toxicology letters 1986;34(1):67-74.
1986: Mason G; Farrell K; Keys B; Piskorska-Pliszczynska J; Safe L; Safe S
Polychlorinated dibenzo-p-dioxins: quantitative in vitro and in vivo structure-activity relationships.
Toxicology 1986;41(1):21-31.
1986: Leece B D; Denomme M A; Li S M; Towner R A; Gyorkos J W; Chittim B G; Safe S
Effects of individual terphenyls and polychlorinated terphenyls on rat hepatic microsomal cytochrome P-450-dependent monooxygenases: structure-activity relationships.
Archives of toxicology 1986;59(3):186-9.
1986: Sawyer T; Jones D; Rosanoff K; Mason G; Piskorska-Pliszczynska J; Safe S
The biologic and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in chickens.
Toxicology 1986;39(2):197-206.
1986: Keys B; Piskorska-Pliszczynska J; Safe S
Polychlorinated dibenzofurans as 2,3,7,8-TCDD antagonists: in vitro inhibition of monooxygenase enzyme induction.
Toxicology letters 1986;31(2):151-8.
1986: Denomme M A; Homonko K; Fujita T; Sawyer T; Safe S
Substituted polychlorinated dibenzofuran receptor binding affinities and aryl hydrocarbon hydroxylase induction potencies--a QSAR analysis.
Chemico-biological interactions 1986;57(2):175-87.
1986: Denomme M A; Leece B; Li A; Towner R; Safe S
Elevation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) polychlorinated biphenyls. Structure-activity relationships.
Biochemical pharmacology 1986;35(2):277-82.
1986: Li S M; Denomme M A; Leece B; Safe S; Dutton D; Parkinson A; Thomas P E; Ryan D; Bandiera S; Reik L M
Hexachlorobenzene and substituted pentachlorobenzenes (X-C6Cl5) as inducers of hepatic cytochrome P-450-dependent mono-oxygenases.
IARC scientific publications 1986;(77):527-34.
1985: Keys B; Hlavinka M; Mason G; Safe S
Modulation of rat hepatic microsomal testosterone hydroxylases by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related toxic isostereomers.
Canadian journal of physiology and pharmacology 1985;63(12):1537-42.
1985: Mason G; Sawyer T; Keys B; Bandiera S; Romkes M; Piskorska-Pliszczynska J; Zmudzka B; Safe S
Polychlorinated dibenzofurans (PCDFs): correlation between in vivo and in vitro structure-activity relationships.
Toxicology 1985;37(1-2):1-12.
1985: Safe S; Bandiera S; Sawyer T; Zmudzka B; Mason G; Romkes M; Denomme M A; Sparling J; Okey A B; Fujita T
Effects of structure on binding to the 2,3,7,8-TCDD receptor protein and AHH induction--halogenated biphenyls.
Environmental health perspectives 1985;61():21-33.
1985: Denomme M A; Homonoko K; Fujita T; Sawyer T; Safe S
Effects of substituents on the cytosolic receptor-binding avidities and aryl hydrocarbon hydroxylase induction potencies of 7-substituted 2,3-dichlorodibenzo-p-dioxins. A quantitative structure-activity relationship analysis.
Molecular pharmacology 1985;27(6):656-61.
1985: Safe S; Bandiera S; Sawyer T; Robertson L; Safe L; Parkinson A; Thomas P E; Ryan D E; Reik L M; Levin W
PCBs: structure-function relationships and mechanism of action.
Environmental health perspectives 1985;60():47-56.
1985: Gyorkos J; Denomme M A; Leece B; Homonko K; Valli V E; Safe S
Reconstituted halogenated hydrocarbon pesticide and pollutant mixtures found in human tissues: effects on the immature male Wistar rat after short-term exposure.
Canadian journal of physiology and pharmacology 1985;63(1):36-43.
1985: Leece B; Denomme M A; Towner R; Li S M; Safe S
Polychlorinated biphenyls: correlation between in vivo and in vitro quantitative structure-activity relationships (QSARs).
Journal of toxicology and environmental health 1985;16(3-4):379-88.
1984: Bandiera S; Sawyer T; Romkes M; Zmudzka B; Safe L; Mason G; Keys B; Safe S
Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity.
Toxicology 1984;32(2):131-44.
1983: Denomme M A; Bandiera S; Lambert I; Copp L; Safe L; Safe S
Polychlorinated biphenyls as phenobarbitone-type inducers of microsomal enzymes. Structure-activity relationships for a series of 2,4-dichloro-substituted congeners.
Biochemical pharmacology 1983;32(19):2955-63.
1983: Denomme M A; Leece B; Gyorkos J; Homonko K; Safe S
Polychlorinated benzene and phenol congeners as inducers of rat hepatic drug-metabolizing enzymes in immature male Wistar rats.
Canadian journal of physiology and pharmacology 1983;61(9):1063-70.
1983: Andres J; Lambert I; Robertson L; Bandiera S; Sawyer T; Lovering S; Safe S
The comparative biologic and toxic potencies of polychlorinated biphenyls and polybrominated biphenyls.
Toxicology and applied pharmacology 1983;70(2):204-15.
1983: Campbell M A; Gyorkos J; Leece B; Homonko K; Safe S
The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes.
General pharmacology 1983;14(4):445-54.
1982: Bandiera S; Sawyer T; Campbell M A; Robertson L; Safe S
Halogenated biphenyls as AHH inducers: effects of different halogen substituents.
Life sciences 1982;31(6):517-25.
1982: Safe S; Robertson L W; Safe L; Parkinson A; Bandiera S; Sawyer T; Campbell M A
Halogenated biphenyls: molecular toxicology.
Canadian journal of physiology and pharmacology 1982;60(7):1057-64.
1982: Bandiera S; Safe S; Okey A B
Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene- or mixed-type inducers to cytosolic Ah receptor.
Chemico-biological interactions 1982;39(3):259-77.
1981: Parkinson A; Robertson L W; Safe L; Safe S
Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: effects of di-ortho substitution.
Chemico-biological interactions 1981;35(1):1-12.
1980: Parkinson A; Robertson L; Safe L; Safe S
Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: structure-activity rules.
Chemico-biological interactions 1980;30(3):271-85.

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