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Richard Saffery

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Cong Sun; Peter J Vuillermin; David P Burgner; Michael Cheung; Rae-Chi Huang; Anne-Louise Ponsonby; Richard Saffery; Jeffrey M Craig
Effects of early-life environment and epigenetics on cardiovascular disease risk in children: highlighting the role of twin studies.
Boris Novakovic; Richard Saffery
The importance of the intrauterine environment in shaping the human neonatal epigenome.
Yuk Jing Loke; Ruth Morley; Boris Novakovic; Miina Ollikainen; Michael Permezel; Anne-Louise Ponsonby; Richard Saffery; Mark P Umstad; Euan M Wallace; John C Galati; Lavinia Gordon; Jeffrey M Craig
The Peri/postnatal Epigenetic Twins Study (PETS).

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2013: Cong Sun; Peter J Vuillermin; David P Burgner; Michael Cheung; Rae-Chi Huang; Anne-Louise Ponsonby; Richard Saffery; Jeffrey M Craig
Effects of early-life environment and epigenetics on cardiovascular disease risk in children: highlighting the role of twin studies.
Pediatric research 2013;73(4 Pt 2):523-30.
2013: Boris Novakovic; Richard Saffery
The importance of the intrauterine environment in shaping the human neonatal epigenome.
Epigenomics 2013;5(1):1-4.
2013: Yuk Jing Loke; Ruth Morley; Boris Novakovic; Miina Ollikainen; Michael Permezel; Anne-Louise Ponsonby; Richard Saffery; Mark P Umstad; Euan M Wallace; John C Galati; Lavinia Gordon; Jeffrey M Craig
The Peri/postnatal Epigenetic Twins Study (PETS).
Twin research and human genetics : the official journal of the International Society for Twin Studies 2013;16(1):13-20.
2013: Elizabeth Scarr; M S Seo; B Weinrich; N J Beveridge; M J Cairns; A P Carroll; J M Craig; J C Galati; A Gibbons; S Juzva; M Parkinson-Bates; Richard Saffery; Brian Dean
Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA.
Translational psychiatry 2013;3():e230.
2013: Boris Novakovic; Wendy P Robinson; Gernot Desoye; Lavinia Gordon; Richard Saffery
Glucose as a fetal nutrient: dynamic regulation of several glucose transporter genes by DNA methylation in the human placenta across gestation.
The Journal of nutritional biochemistry 2013;24(1):282-8.
2012: B Novakovic; Richard Saffery
The ever growing complexity of placental epigenetics - role in adverse pregnancy outcomes and fetal programming.
Placenta 2012;33(12):959-70.
2012: Jonathan Ip; Shelley A Jacobs; Paul Kalitsis; Deidre M Mattiske; Jane Ng; Richard Saffery; Lee H Wong; Nicholas C Wong; Paul Canham; K H Andy Choo; Yoshimi Inaba; Jeffrey R Mann
Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells.
PLoS genetics 2012;8(9):e1002919.
2012: Lavinia Gordon; Jihoon E Joo; Xin Li; Ruth Morley; Boris Novakovic; Miina Ollikainen; Joseph E Powell; Reid S Alisch; Roberta Andronikos; Karen N Conneely; Jeffrey M Craig; Mark Nicholas Cruickshank; Alicia K Smith; Peter M Visscher; Richard Saffery
Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence.
Genome research 2012;22(8):1395-406.
2012: Boris Novakovic; Anna Chen; Jeffrey M Craig; John C Galati; Ruth Morley; Richard Saffery
Maternal vitamin D predominates over genetic factors in determining neonatal circulating vitamin D concentrations.
The American journal of clinical nutrition 2012;96(1):188-95.
2012: Nicholas C Wong; Qiao Wang; Elizabeth Algar; David Ashley; Justin Bedo; Katrina Bell; Zac Chatterton; Jeffrey M Craig; Minhee S Halemba; Adam Kowalczyk; Hong Kiat Ng; Mandy Parkinson-Bates; Richard Saffery
A distinct DNA methylation signature defines pediatric pre-B cell acute lymphoblastic leukemia.
Epigenetics : official journal of the DNA Methylation Society 2012;7(6):535-41.
2012: MARGUERITE EVANS-GALEA; John C Galati; Christopher M Gomez; Lingli Li; David R Lynch; SL Perlman; Sean R Regner; Simone M Rowley; Richard Saffery; Alicia F D Brocht; Khalaf O Bushara; Nissa Carrodus; Louise A Corben; Jeffrey M Craig; Martin Delatycki; Geneieve Tai; Elizabeth Varley; George R Wilmot; Nicholas C Wong; Joseph P Sarsero
FXN methylation predicts expression and clinical outcome in Friedreich ataxia.
Annals of neurology 2012;71(4):487-97.
2012: F Lyn Chan; K H Andy Choo; Elizabeth Earle; Owen J Marshall; Richard Saffery; Bo Won Kim; Lee H Wong
Active transcription and essential role of RNA polymerase II at the centromere during mitosis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(6):1979-84.
2012: Richard Saffery; Mark P Umstad; Euan M Wallace; Roberta Andronikos; John B Carlin; Nicole Carson; John C Galati; Ji-Hoon Eric Joo; Xin Li; Yuk Jing Loke; Ruth Morley; Boris Novakovic; Miina Ollikainen; Michael Permezel; Jeffrey M Craig
Cohort profile: The peri/post-natal epigenetic twins study.
International journal of epidemiology 2012;41(1):55-61.
2012: Jordana T Bell; Richard Saffery
The value of twins in epigenetic epidemiology.
International journal of epidemiology 2012;41(1):140-50.
2012: Warrick J Inder; Christina Jang; Varuni R Obeyesekere; Richard Saffery
Evidence for transcript-specific epigenetic regulation of glucocorticoid-stimulated skeletal muscle 11β-hydroxysteroid dehydrogenase-1 activity in type 2 diabetes.
Clinical epigenetics 2012;4(1):24.
2012: Justine A Ellis; Lavinia Gordon; Jihoon E Joo; Jane E Munro; Anne-Louise Ponsonby; JD Akikusa; Roger C Allen; Raul A Chavez; Jeffrey M Craig; Richard Saffery
Genome-scale case-control analysis of CD4+ T-cell DNA methylation in juvenile idiopathic arthritis reveals potential targets involved in disease.
Clinical epigenetics 2012;4(1):20.
2012: Leah Morenos; Richard Saffery; David Ashley; Jeffrey M Craig; Ngaire Elwood; Francoise Mechinaud; Nicholas C Wong
Evaluation of microRNA expression in patient bone marrow aspirate slides.
PloS one 2012;7(8):e42951.
2011: Laura E Hogan; Stephen P Hunger; Julia A Meyer; Debra J Morrison; Elizabeth A Raetz; Mary V Relling; Richard Saffery; Jinhua Wang; Nicholas Wong; Jun Yang; Wenjian Yang; Deepa Bhojwani; Gregory Condos; William L Carroll
Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies.
Blood 2011;118(19):5218-26.
2011: Susan L Prescott; Tara Richman; Richard Saffery; Meri K Tulic; Annette Osei Kumah; Maxine Crook; Janet A Dunstan; David Martino; Boris Novakovic; Vicki L Clifton
Reduced placental FOXP3 associated with subsequent infant allergic disease.
The Journal of allergy and clinical immunology 2011;128(4):886-887.e5.
2011: David J Martino; Jessica Metcalfe; Susan L Prescott; Tara R Richman; Lavinia Gordon; Megan Hodder; Meri K Tulic; Richard Saffery
Evidence for age-related and individual-specific changes in DNA methylation profile of mononuclear cells during early immune development in humans.
Epigenetics : official journal of the DNA Methylation Society 2011;6(9):1085-94.
2011: Boris Novakovic; Lavinia Gordon; Nicholas C Wong; Ashley Moffett; Ursula Manuelpillai; Jeffrey M Craig; Andrew Sharkey; Richard Saffery
Wide-ranging DNA methylation differences of primary trophoblast cell populations and derived cell lines: implications and opportunities for understanding trophoblast function.
Molecular human reproduction 2011;17(6):344-53.
2011: Lavinia Gordon; Ji-Hoon E Joo; Roberta Andronikos; Miina Ollikainen; Euan M Wallace; Mark P Umstad; Michael Permezel; Alicia Oshlack; Ruth Morley; John B Carlin; Richard Saffery; Gordon K Smyth; Jeffrey M Craig
Expression discordance of monozygotic twins at birth: effect of intrauterine environment and a possible mechanism for fetal programming.
Epigenetics : official journal of the DNA Methylation Society 2011;6(5):579-92.
2011: Boris Novakovic; Maria S Penaherrera; Wendy P Robinson; Jeffrey M Craig; Lavinia Gordon; Ashley Moffett; Andrew Sharkey; Ryan Yuen; Richard Saffery
Evidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors.
BMC genomics 2011;12():529.
2011: Musa Drini; Nicholas C Wong; Hamish S Scott; Jeffrey M Craig; Alexander Dobrovic; Chelsee A Hewitt; Christofer Dow; Joanne P Young; Mark A Jenkins; Richard Saffery; Finlay A Macrae
Investigating the potential role of genetic and epigenetic variation of DNA methyltransferase genes in hyperplastic polyposis syndrome.
PloS one 2011;6(2):e16831.
2010: Miina Ollikainen; Katherine R Smith; Eric Ji-Hoon Joo; Hong Kiat Ng; Roberta Andronikos; Boris Novakovic; Nur Khairunnisa Abdul Aziz; John B Carlin; Ruth Morley; Richard Saffery; Jeffrey M Craig
DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome.
Human molecular genetics 2010;19(21):4176-88.
2010: Petra S Bachmann; Rocco G Piazza; Mary E Janes; Nicholas C Wong; Carwyn Davies; Angela Mogavero; Vivek A Bhadri; B Szymanska; Greta Geninson; Vera Magistroni; Giovanni Cazzaniga; Andrea Biondi; Diego Miranda-Saavedra; Berthold Göttgens; Richard Saffery; Jeffrey M Craig; Glenn M Marshall; Carlo Gambacorti-Passerini; John E Pimanda; Richard B Lock
Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition.
Blood 2010;116(16):3013-22.
2010: Zac Chatterton; Jeffrey M Craig; Leah Morenos; Richard Saffery; David Ashley; Nicholas C Wong
DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia.
Epigenomics 2010;2(5):697-708.
2010: Boris Novakovic; Richard Saffery
DNA methylation profiling highlights the unique nature of the human placental epigenome.
Epigenomics 2010;2(5):627-38.
2010: M S Zajac; T Y C Pang; N Wong; B Weinrich; L S K Leang; J M Craig; Richard Saffery; Anthony J Hannan
Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice.
Hippocampus 2010;20(5):621-36.
2010: Hong Kiat Ng; B Novakovic; Stefan Hiendleder; Jeffrey M Craig; C T Roberts; Richard Saffery
Distinct patterns of gene-specific methylation in mammalian placentas: implications for placental evolution and function.
Placenta 2010;31(4):259-68.
2010: Boris Novakovic; Nick C Wong; Mandy Sibson; Hong Kiat Ng; Ruth Morley; Ursula Manuelpillai; Thomas Down; Vardhman K Rakyan; Stephan Beck; Stefan Hiendleder; Claire T Roberts; Jeffrey M Craig; Richard Saffery
DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta.
The Journal of biological chemistry 2010;285(13):9583-93.
2010: Matthew A Sabin; Susan L Clemens; Richard Saffery; Zoe McCallum; Michele W Campbell; Wieland Kiess; Nancy A Crimmins; Jessica G Woo; Gary Martin Leong; George Werther; Obioha C Ukoumunne; Melissa Wake
New directions in childhood obesity research: how a comprehensive biorepository will allow better prediction of outcomes.
BMC medical research methodology 2010;10():100.
2009: Richard Saffery; Justine Ellis; Ruth Morley
A convergent model for placental dysfunction encompassing combined sub-optimal one-carbon donor and vitamin D bioavailability.
Medical hypotheses 2009;73(6):1023-8.
2009: Margaret L Shaw; Evan J Williams; Susan Hawes; Richard Saffery
Characterisation of histone variant distribution in human embryonic stem cells by transfection of in vitro transcribed mRNA.
Molecular reproduction and development 2009;76(12):1128-42.
2009: Anne-Louise Ponsonby; Fergus Cameron; Richard Saffery; Angela Pezic; Nick Wong; Jeff Craig; Justine Ellis; Terence Dwyer
A case-sibling assessment of the association between skin pigmentation and other vitamin D-related factors and type 1 diabetes mellitus.
Photochemistry and photobiology 2009;85(5):1267-70.
2009: Boris Novakovic; Mandy Sibson; Hong Kiat Ng; Ursula Manuelpillai; Vardhman Rakyan; Thomas Down; Stephan Beck; Thierry Fournier; Danielle Evain-Brion; Eva Dimitriadis; Jeffrey M Craig; Ruth Morley; Richard Saffery
Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface.
The Journal of biological chemistry 2009;284(22):14838-48.
2009: Debra L Foley; Jeffrey M Craig; Ruth Morley; Craig A Olsson; Craig J Olsson; Terence Dwyer; Katherine Smith; Richard Saffery
Prospects for epigenetic epidemiology.
American journal of epidemiology 2009;169(4):389-400.
2009: Paul Kalitsis; Richard Saffery
Inherent promoter bidirectionality facilitates maintenance of sequence integrity and transcription of parasitic DNA in mammalian genomes.
BMC genomics 2009;10():498.
2009: Elizabeth M Algar; Andrea Muscat; Vinod Dagar; Christian H Rickert; C W Chow; Jaclyn A Biegel; Paul G Ekert; Richard Saffery; Jeff Craig; Ricky Johnstone; David M Ashley
Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors.
PloS one 2009;4(2):e4482.
2008: Nicholas Wong; Ruth Morley; Richard Saffery; Jeffrey Craig
Archived Guthrie blood spots as a novel source for quantitative DNA methylation analysis.
BioTechniques 2008;45(4):423-4, 426, 428 passim.
2008: B Novakovic; V Rakyan; Hong Kiat Ng; U Manuelpillai; C Dewi; N C Wong; R Morley; T Down; S Beck; Jeffrey M Craig; Richard Saffery
Specific tumour-associated methylation in normal human term placenta and first-trimester cytotrophoblasts.
Molecular human reproduction 2008;14(9):547-54.
2007: Lee H Wong; Kate H Brettingham-Moore; Lyn Chan; Julie M Quach; Melissa A Anderson; Emma L Northrop; Ross Hannan; Richard Saffery; Margaret L Shaw; Evan Williams; K H Andy Choo
Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere.
Genome research 2007;17(8):1146-60.
2005: Danielle V Irvine; Margaret L Shaw; K H Andy Choo; Richard Saffery
Engineering chromosomes for delivery of therapeutic genes.
Trends in biotechnology 2005;23(12):575-83.
2005: Lee H Wong; Richard Saffery; Melissa A Anderson; Elizabeth Earle; Julie M Quach; Angela J Stafford; Kerry J Fowler; K H Andy Choo
Analysis of mitotic and expression properties of human neocentromere-based transchromosomes in mice.
The Journal of biological chemistry 2005;280(5):3954-62.
2004: Huseyin Sumer; Richard Saffery; Nicholas Wong; Jeffrey M Craig; K H Andy Choo
Effects of scaffold/matrix alteration on centromeric function and gene expression.
The Journal of biological chemistry 2004;279(36):37631-9.
2004: Danielle V Irvine; David J Amor; Jo Perry; Nicolas Sirvent; Florence Pedeutour; K H Andy Choo; Richard Saffery
Chromosome size and origin as determinants of the level of CENP-A incorporation into human centromeres.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2004;12(8):805-15.
2003: Richard Saffery; Huseyin Sumer; Sara Hassan; Lee H Wong; Jeffrey M Craig; Kazuo Todokoro; Melissa Anderson; Angela J Stafford; K H Andy Choo
Transcription within a functional human centromere.
Molecular cell 2003;12(2):509-16.
2003: Zhonglin Chai; Phillip Brereton; Takashi Suzuki; Hironobu Sasano; Varuni R Obeyesekere; Genevieve Escher; Richard Saffery; Peter Fuller; Carla Enriquez; Zygmunt Krozowski
17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells.
Endocrinology 2003;144(5):2084-91.
2002: Alka Saxena; Richard Saffery; Lee H Wong; Paul Kalitsis; K H Andy Choo
Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated.
The Journal of biological chemistry 2002;277(30):26921-6.
2002: Lee H Wong; Richard Saffery; K H Andy Choo
Construction of neocentromere-based human minichromosomes for gene delivery and centromere studies.
Gene therapy 2002;9(11):724-6.
2002: Richard Saffery; K H Andy Choo
Strategies for engineering human chromosomes with therapeutic potential.
The journal of gene medicine 2002;4(1):5-13.
2001: Lucille Voullaire; Richard Saffery; Elizabeth Earle; Danielle V Irvine; Howard R Slater; S Dale; Desirée Du Sart; T Fleming; K H Andy Choo
Mosaic inv dup(8p) marker chromosome with stable neocentromere suggests neocentromerization is a post-zygotic event.
American journal of medical genetics 2001;102(1):86-94.
2001: Richard Saffery; Lee H Wong; Danielle V Irvine; M A Bateman; Belinda Griffiths; SM Cutts; Michael Cancilla; A C Cendron; Angela J Stafford; K H Andy Choo
Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5705-10.
2001: Anthony W I Lo; Jeffrey M Craig; Richard Saffery; Paul Kalitsis; Danielle V Irvine; Elizabeth Earle; D J Magliano; K H Andy Choo
A 330 kb CENP-A binding domain and altered replication timing at a human neocentromere.
The EMBO journal 2001;20(8):2087-96.
2000: Richard Saffery; Danielle V Irvine; Belinda Griffiths; Paul Kalitsis; K H Andy Choo
Components of the human spindle checkpoint control mechanism localize specifically to the active centromere on dicentric chromosomes.
Human genetics 2000;107(4):376-84.
2000: Alyssa Barry; M Bateman; Emily Howman; Michael Cancilla; KM Tainton; Danielle V Irvine; Richard Saffery; K H Andy Choo
The 10q25 neocentromere and its inactive progenitor have identical primary nucleotide sequence: further evidence for epigenetic modification.
Genome research 2000;10(6):832-8.
2000: Daniel A Starr; Richard Saffery; Zexiao Li; A E Simpson; K H Andy Choo; Tim J Yen; Michael L Goldberg
HZwint-1, a novel human kinetochore component that interacts with HZW10.
Journal of cell science 2000;113 ( Pt 11)():1939-50.
2000: Elizabeth Earle; Alka Saxena; A MacDonald; DF Hudson; Lisa Shaffer; Richard Saffery; Michael Cancilla; SM Cutts; Emily Howman; K H Andy Choo
Poly(ADP-ribose) polymerase at active centromeres and neocentromeres at metaphase.
Human molecular genetics 2000;9(2):187-94.
2000: Richard Saffery; Danielle V Irvine; Belinda Griffiths; Paul Kalitsis; L Wordeman; K H Andy Choo
Human centromeres and neocentromeres show identical distribution patterns of >20 functionally important kinetochore-associated proteins.
Human molecular genetics 2000;9(2):175-85.
1999: Lucille Voullaire; Richard Saffery; J Davies; Elizabeth Earle; Paul Kalitsis; Howard R Slater; Danielle V Irvine; K H Andy Choo
Trisomy 20p resulting from inverted duplication and neocentromere formation.
American journal of medical genetics 1999;85(4):403-8.
1999: SM Cutts; Kerry J Fowler; BT Kile; L L Hii; R A O'Dowd; DF Hudson; Richard Saffery; Paul Kalitsis; Elizabeth Earle; K H Andy Choo
Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice.
Human molecular genetics 1999;8(7):1145-55.
1999: Richard Saffery; Danielle V Irvine; BT Kile; DF Hudson; SM Cutts; K H Andy Choo
Cloning, expression, and promoter structure of a mammalian inner centromere protein (INCENP).
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(4):415-8.
1999: Alyssa Barry; Emily Howman; Michael Cancilla; Richard Saffery; K H Andy Choo
Sequence analysis of an 80 kb human neocentromere.
Human molecular genetics 1999;8(2):217-27.
1999: Richard Saffery; Elizabeth Earle; Danielle V Irvine; Paul Kalitsis; K H Andy Choo
Conservation of centromere protein in vertebrates.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 1999;7(4):261-5.
1998: DF Hudson; Kerry J Fowler; Elizabeth Earle; Richard Saffery; Paul Kalitsis; HE Trowell; J Hill; N G Wreford; D M de Kretser; Michael Cancilla; Emily Howman; L Hii; SM Cutts; Danielle V Irvine; K H Andy Choo
Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weights.
The Journal of cell biology 1998;141(2):309-19.
1998: Kerry J Fowler; Richard Saffery; Danielle V Irvine; HE Trowell; K H Andy Choo
Mouse centromere protein F (Cenpf) gene maps to the distal region of chromosome 1 by interspecific backcross analysis.
Cytogenetics and cell genetics 1998;82(3-4):180-1.
1998: Kerry J Fowler; Richard Saffery; BT Kile; Danielle V Irvine; DF Hudson; HE Trowell; K H Andy Choo
Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes.
Cytogenetics and cell genetics 1998;82(1-2):67-70.
1997: Desirée Du Sart; Michael Cancilla; Elizabeth Earle; J I Mao; Richard Saffery; KM Tainton; Paul Kalitsis; J Martyn; Alyssa Barry; K H Andy Choo
A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA.
Nature genetics 1997;16(2):144-53.
1995: Anthony Albiston; Richard Saffery; A C Herington
Cloning and characterization of the promoter for the rat insulin-like growth factor-binding protein-3 gene.
Endocrinology 1995;136(2):696-704.