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Paul Saftig

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Katherine R Smith; John F Staropoli; Noreen A Alexander; Eva Andermann; Frederick Andermann; Samuel F Berkovic; Amalia C Bruni; Laura Canafoglia; Stirling Carpenter; Harold A Chapman; Jonathan D Cooper; Patrick Cossette; Hans-Henrik M Dahl; John Damiano; Silvana Franceschetti; Giorgio Giaccone; Joachim Grötzinger; Sara E Mole; Michela Morbin; Paul Saftig; Michael Schwake; Katherine B Sims; Melanie Bahlo
Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis.
Christian Sina; Andreas Till; Paul Saftig; Stefan Schreiber; Konrad Aden; Olga Gavrilova; Robert Haesler; Simone Lipinski; Michael A McGuckin; Ulf Meyer-Hoffert; Emilie Midtling; Rainer Podschun; Katrin Pütsep; Ateequr Rehman; Andrea Rittger; Philip Rosenstiel
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice.
Anna Ulbricht; Padmanabhan Vakeel; Peter F.M. van der Ven; Rudolf Volkmer; Waldemar Kolanus; Paul Saftig; Daniela Stadel; Victor E Tapia; Christian Behrends; Felix J Eppler; Dieter O Fürst; Albert Haas; Nico Hampe; Nils Hersch; Bernd Hoffmann; Jörg Höhfeld
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.

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All Publications

2013: Katherine R Smith; John F Staropoli; Noreen A Alexander; Eva Andermann; Frederick Andermann; Samuel F Berkovic; Amalia C Bruni; Laura Canafoglia; Stirling Carpenter; Harold A Chapman; Jonathan D Cooper; Patrick Cossette; Hans-Henrik M Dahl; John Damiano; Silvana Franceschetti; Giorgio Giaccone; Joachim Grötzinger; Sara E Mole; Michela Morbin; Paul Saftig; Michael Schwake; Katherine B Sims; Melanie Bahlo
Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis.
Human molecular genetics 2013;22(7):1417-23.
2013: Christian Sina; Andreas Till; Paul Saftig; Stefan Schreiber; Konrad Aden; Olga Gavrilova; Robert Haesler; Simone Lipinski; Michael A McGuckin; Ulf Meyer-Hoffert; Emilie Midtling; Rainer Podschun; Katrin Pütsep; Ateequr Rehman; Andrea Rittger; Philip Rosenstiel
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice.
Gut 2013;62(4):520-30.
2013: Anna Ulbricht; Padmanabhan Vakeel; Peter F.M. van der Ven; Rudolf Volkmer; Waldemar Kolanus; Paul Saftig; Daniela Stadel; Victor E Tapia; Christian Behrends; Felix J Eppler; Dieter O Fürst; Albert Haas; Nico Hampe; Nils Hersch; Bernd Hoffmann; Jörg Höhfeld
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.
Current biology : CB 2013;23(5):430-5.
2013: Masato Koike; Eiki Kominami; Christoph Peters; Paul Saftig; Masahiro Shibata; Junji Ezaki; Yasuo Uchiyama
Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system.
The European journal of neuroscience 2013;37(5):816-30.
2013: Janna Schneppenheim; Jürgen Wienands; Kai Dittmann; Ralf Dressel; Michael Engelke; Eeva-Liisa Eskelinen; Regina Fluhrer; Irm Hermans-Borgmeyer; Susann Hüttl; Renate Lüllmann-Rauch; Paul Saftig; Bernd Schröder
The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.
The Journal of experimental medicine 2013;210(1):41-58.
2012: Maria Arampatzidou; Gunnar C Hansson; Paul Saftig; André Schütte; Klaudia Brix
Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon.
Biological chemistry 2012;393(12):1391-403.
2012: Kunimichi Suzuki; Shun Tanimura; Taisuke Tomita; Satoshi Yokoshima; Mingshuo Zeng; Tohru Fukuyama; Yukari Hayashi; Keisuke Horiuchi; Ryuta Koyama; Hiroshi Kumazaki; Norio Matsuki; Soichiro Nakahara; Yoshitake Nishiyama; Satoko Osawa; Johannes Prox; Paul Saftig; Atsuko Sehara-Fujisawa; Takeshi Iwatsubo
Activity-dependent proteolytic cleavage of neuroligin-1.
Neuron 2012;76(2):410-22.
2012: Silvio Weber; Paul Saftig
Ectodomain shedding and ADAMs in development.
Development (Cambridge, England) 2012;139(20):3693-709.
2012: Özlem Demirel; Judith Blanz; Irina Jan; Paul Saftig; Robert Tampé; Dirk Wolters; Rupert Abele
The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2.
Journal of cell science 2012;125(Pt 18):4230-40.
2012: Jun Cai; Zhijuan Chen; Bart De Strooper; Alonso Emilio; Todd Golde; Maria B Grant; Song Han; Antonia M Joussen; Norbert Kociok; Li Liu; Xiaoping Qi; Qing Ruan; Paul Saftig; Lutgarde Serneels; Sergej Skosyrski; Catherine Bowes Rickman; Michael E Boulton
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
EMBO molecular medicine 2012;4(9):980-91.
2012: Grace Tharmarajah; Laura Faas; Karina Reiss; Paul Saftig; Antony Young; Catherine D Van Raamsdonk
Adam10 haploinsufficiency causes freckle-like macules in Hairless mice.
Pigment cell & melanoma research 2012;25(5):555-65.
2012: Johannes Prox; Paul Saftig; Dirk Schmidt-Arras; Ralf Schwanbeck; Silvio Weber; Michael Willenbrock; Tobias Lehmann; Michael Schwake
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.
Cellular and molecular life sciences : CMLS 2012;69(17):2919-32.
2012: Christina Zachos; Judith Blanz; Paul Saftig; Michael Schwake
A critical histidine residue within LIMP-2 mediates pH sensitive binding to its ligand β-glucocerebrosidase.
Traffic (Copenhagen, Denmark) 2012;13(8):1113-23.
2012: Haixia Xu; Baohong Zhao; Jimmy Zhu; Carl P Blobel; Allen Y Chung; Julia Foldi; Lionel B Ivashkiv; Jan Kitajewski; Yueming Li; Hasina Outtz; Keiko Ozato; Paul Saftig; Chao Shi; Sinead Smith; Silvio Weber; Xiaoyu Hu
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
Nature immunology 2012;13(7):642-50.
2012: Johannes Prox; Andrea Rittger; Paul Saftig
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2012;217(3-4):331-41.
2012: Georgia Makrypidi; Sven Müller-Loennies; Paul Saftig; Hartmut Schlüter; Bernhard Schmidt; Maria Trusch; Markus Damme; Joerg Heeren; Torben Lübke; Thomas Braulke
Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.
Molecular and cellular biology 2012;32(4):774-82.
2012: Hanna Appelqvist; K Björnström; Brett Garner; Karin Ollinger; Paul Saftig; Linnea Sandin; Katarina Kågedal
Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content.
PloS one 2012;7(11):e50262.
2011: Guillaume van Niel; Stéphanie Charrin; Michael S Marks; Leila Rochin; Maryse Romao; Eric Rubinstein; Paul Saftig; Sabrina Simoes; Graça Raposo
The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.
Developmental cell 2011;21(4):708-21.
2011: Emily L Doyle; Francesco Ferraro; Victoria Ridger; Paul Saftig; Mark Turmaine; Daniel F Cutler
CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin.
Blood 2011;118(15):4265-73.
2011: Jörg Behnke; Friedrich Haag; Friedrich Koch-Nolte; Paul Saftig; Janna Schneppenheim; Bernd Schröder
Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail.
FEBS letters 2011;585(19):2951-7.
2011: Sabine Rabe; Julia Reichwald; Paul Saftig; Domenico Ammaturo; Bart De Strooper; Ulf Neumann; Matthias Staufenbiel
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.
Journal of neurochemistry 2011;119(1):231-9.
2011: Lalu Rudyat Telly Savalas; Christian Wrocklage; Markus Damme; Cécile Debacker; Bruno Gasnier; Andrej Hasilik; Adrien Jézégou; Torben Lübke; Thomas Reinheckel; Paul Saftig; Bernd Schröder
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.
The Biochemical journal 2011;439(1):113-28.
2011: Sarah Felice Evans; Carl Blobel; Krithi Irmady; Taeho Kim; Anders Nykjaer; Katya Ostrow; Paul Saftig; Barbara L Hempstead
Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.
The Journal of biological chemistry 2011;286(34):29556-67.
2011: Krzysztof Glomski; Katia Manova-Todorova; Sébastien Monette; Paul Saftig; Bart De Strooper; Carl P Blobel
Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures.
Blood 2011;118(4):1163-74.
2011: Valerie Cullen; Marcie A Glicksman; Gregory A Grabowski; Ilana Kahn; Piotr Kolodziej; Juliana Ng; Jean-Christophe Rochet; Paul Saftig; S Pablo Sardi; Lamya S Shihabuddin; Ying Sun; Julianna J Tomlinson; John Woulfe; You-Hai Xu; Seng H Cheng; Michael G Schlossmacher
Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.
Annals of neurology 2011;69(6):940-53.
2011: M J Desmond; Scott A Fraser; K Gleich; Marina Katerelos; D Lee; Y Q Li; Paul Martinello; R Michelucci; Paul Saftig; M Schwake; D Stapleton; Merlin C Thomas; Samuel F Berkovic; A J Cole; David A Power
Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2.
American journal of physiology. Renal physiology 2011;300(6):F1437-47.
2011: Paul Saftig; Karina Reiss
The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: novel drug targets with therapeutic potential?
European journal of cell biology 2011;90(6-7):527-35.
2011: Tobias Huth; Andrea Rittger; Paul Saftig; Christian Alzheimer
β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current.
Pflügers Archiv : European journal of physiology 2011;461(3):355-71.
2011: Jörg Behnke; Eeva-Liisa Eskelinen; Paul Saftig; Bernd Schröder
Two dileucine motifs mediate late endosomal/lysosomal targeting of transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers.
The Biochemical journal 2011;434(2):219-31.
2011: Eugenio Carrasco-Marín; Lorena Fernández-Prieto; Estela Rodriguez-Del Rio; Fidel Madrazo-Toca; Thomas Reinheckel; Paul Saftig; Carmen Alvarez-Dominguez
LIMP-2 links late phagosomal trafficking with the onset of the innate immune response to Listeria monocytogenes: a role in macrophage activation.
The Journal of biological chemistry 2011;286(5):3332-41.
2011: Irfan Y Tamboli; Heike Hampel; Nguyen T Tien; Karen Tolksdorf; Bernadette Breiden; Paul M Mathews; Paul Saftig; Konrad Sandhoff; Jochen Walter
Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(5):1837-49.
2011: Silvio Weber; Michaela T Niessen; Johannes Prox; Renate Lüllmann-Rauch; Annika Schmitz; Ralf Schwanbeck; Carl P Blobel; Ellen Jorissen; Bart De Strooper; Carien M Niessen; Paul Saftig
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling.
Development (Cambridge, England) 2011;138(3):495-505.
2011: Alexander Schneede; Marion Willenborg; Judith Blanz; Bernadette Breiden; Susanne Brodesser; Mykola Domanskyy; Jörg Heeren; Maarit Hölttä-Vuori; Elina Ikonen; Jobst Landgrebe; Paul Saftig; Konrad Sandhoff; Christine K Schmidt; Eeva-Liisa Eskelinen
Role for LAMP-2 in endosomal cholesterol transport.
Journal of cellular and molecular medicine 2011;15(2):280-95.
2011: Stephanie Dauth; Silvia Jordans; Alexander Lerchl; Julia Oswald; Maren Rehders; Paul Saftig; Ruxandra F Sîrbulescu; Linda Avena; Klaudia Brix
Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits.
BMC neuroscience 2011;12():74.
2011: Dongwei Zhang; Nelson Leung; Paul Saftig; Ekkehard Weber; Dieter Brömme
The effect of cathepsin K deficiency on airway development and TGF-β1 degradation.
Respiratory research 2011;12():72.
2011: Hermann C Altmeppen; Udo Bartsch; Christian Bernreuther; Bart De Strooper; Ellen Jorissen; Mark A Kluth; Bettina Petrowitz; Johannes Prox; Berta Puig; Paul Saftig; Dana Thurm; Markus Glatzel
Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo.
Molecular neurodegeneration 2011;6():36.
2011: Markus Damme; Stijn Stroobants; Steven U Walkley; Renate Lüllmann-Rauch; Rudi D'Hooge; Jens Fogh; Paul Saftig; Torben Lübke; Judith Blanz
Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in α-mannosidosis.
Journal of neuropathology and experimental neurology 2011;70(1):83-94.
2010: Paul Saftig; Bernd Schröder; Judith Blanz
Lysosomal membrane proteins: life between acid and neutral conditions.
Biochemical Society transactions 2010;38(6):1420-3.
2010: Sylvain M Le Gall; Thorsten Maretzky; Priya D A Issuree; Xiao-Da Niu; Karina Reiss; Paul Saftig; Rama Khokha; Daniel Lundell; Carl P Blobel
ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site.
Journal of cell science 2010;123(Pt 22):3913-22.
2010: Bernd A Schröder; Christian Wrocklage; Andrej Hasilik; Paul Saftig
The proteome of lysosomes.
Proteomics 2010;10(22):4053-76.
2010: Karen Mendelson; Steven Swendeman; Paul Saftig; Carl P Blobel
Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways.
The Journal of biological chemistry 2010;285(32):25024-32.
2010: Athena Chalaris; Nina Adam; Christian Sina; Philip Rosenstiel; Judith Lehmann-Koch; Peter Schirmacher; Dieter Hartmann; Joanna Cichy; Olga Gavrilova; Stefan Schreiber; Thomas Jostock; Vance Matthews; Robert Häsler; Christoph Becker; Markus F Neurath; Karina Reiss; Paul Saftig; Jürgen Scheller; Stefan Rose-John
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
The Journal of experimental medicine 2010;207(8):1617-24.
2010: Jinsook Kim; Christina Lilliehook; Amanda Dudak; Johannes Prox; Paul Saftig; Howard Federoff; Seung T Lim
Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10).
The Journal of biological chemistry 2010;285(30):22919-26.
2010: Zinayida Shevtsova; Manuel Garrido; Jochen H Weishaupt; Paul Saftig; Mathias Bähr; Fred Lühder; Sebastian Kügler
CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis.
The American journal of pathology 2010;177(1):271-9.
2010: Bernd Schröder; Christian Wrocklage; Andrej Hasilik; Paul Saftig
Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane.
Biological chemistry 2010;391(6):695-704.
2010: Bernd Schröder; Paul Saftig
Molecular insights into mechanisms of intramembrane proteolysis through signal peptide peptidase (SPP).
The Biochemical journal 2010;427(3):e1-3.
2010: Ellen Jorissen; Johannes Prox; Christian Bernreuther; Silvio Weber; Ralf Schwanbeck; Lutgarde Serneels; An Snellinx; Katleen Craessaerts; Amantha Thathiah; Ina Tesseur; Udo Bartsch; Gisela Weskamp; Carl P Blobel; Markus Glatzel; Bart De Strooper; Paul Saftig
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(14):4833-44.
2010: Lili Bai; Linda Beckers; Erwin Wijnands; Suzanne P M Lutgens; M Verónica Herías; Paul Saftig; Mat J A P Daemen; Kitty Cleutjens; Esther Lutgens; Erik A L Biessen; Sylvia Heeneman
Cathepsin K gene disruption does not affect murine aneurysm formation.
Atherosclerosis 2010;209(1):96-103.
2010: Judith Blanz; Johann Groth; Christina Zachos; Christina Wehling; Paul Saftig; Michael Schwake
Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-glucocerebrosidase.
Human molecular genetics 2010;19(4):563-72.
2010: Verena Arndt; Nikolaus Dick; Riga Tawo; Michael Dreiseidler; Daniela Wenzel; Michael Hesse; Dieter O Fürst; Paul Saftig; Robert Saint; Bernd K Fleischmann; Michael Hoch; Jörg Höhfeld
Chaperone-assisted selective autophagy is essential for muscle maintenance.
Current biology : CB 2010;20(2):143-8.
2010: Soon-Duck Ha; Boram Ham; Jeremy Mogridge; Paul Saftig; Shengcai Lin; Sung Ouk Kim
Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm.
The Journal of biological chemistry 2010;285(3):2120-9.
2009: Saori Hata; Sayaka Fujishige; Yoichi Araki; Naoko Kato; Masahiko Araseki; Masaki Nishimura; Dieter Hartmann; Paul Saftig; Falk Fahrenholz; Miyako Taniguchi; Katsuya Urakami; Hiroyasu Akatsu; Ralph N Martins; Kazuo Yamamoto; Masahiro Maeda; Tohru Yamamoto; Tadashi Nakaya; Sam Gandy; Toshiharu Suzuki
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
The Journal of biological chemistry 2009;284(52):36024-33.
2009: Martha E Cruz-Soto; Gabriela Cosío; Michael C Jeziorski; Víctor Vargas-Barroso; Manuel B. Aguilar; Alfonso Cárabez; Peter Berger; Paul Saftig; Edith Arnold; Stéphanie Thebault; Gonzalo Martínez de la Escalera; Carmen Clapp
Cathepsin D is the primary protease for the generation of adenohypophyseal vasoinhibins: cleavage occurs within the prolactin secretory granules.
Endocrinology 2009;150(12):5446-54.
2009: Susan Wilson; Saadat Hashamiyan; Lorne Clarke; Paul Saftig; John S Mort; Valeria M Dejica; Dieter Brömme
Glycosaminoglycan-mediated loss of cathepsin K collagenolytic activity in MPS I contributes to osteoclast and growth plate abnormalities.
The American journal of pathology 2009;175(5):2053-62.
2009: Laura Bloch; Olga Sineshchekova; Daniela Reichenbach; Karina Reiss; Paul Saftig; Makoto Kuro-o; Christoph Kaether
Klotho is a substrate for alpha-, beta- and gamma-secretase.
FEBS letters 2009;583(19):3221-4.
2009: Peter W Janes; Sabine H Wimmer-Kleikamp; Achilleas S Frangakis; Kane Treble; Bettina Griesshaber; Ola Sabet; Markus Grabenbauer; Alice Y Ting; Paul Saftig; Philippe I H Bastiaens; Martin Lackmann
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10.
PLoS biology 2009;7(10):e1000215.
2009: Paul Saftig; Judith Klumperman
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.
Nature reviews. Molecular cell biology 2009;10(9):623-35.
2009: Thomas Tousseyn; Amantha Thathiah; Ellen Jorissen; Tim Raemaekers; Uwe Konietzko; Karina Reiss; Elke Maes; An Snellinx; Lutgarde Serneels; Omar Nyabi; Willem ANNAERT; Paul Saftig; Dieter Hartmann; Bart De Strooper
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase.
The Journal of biological chemistry 2009;284(17):11738-47.
2009: Willem ANNAERT; Paul Saftig
Regulated intramembrane proteolysis--a story about sheddases and I-CliPs.
Seminars in cell & developmental biology 2009;20(2):125.
2009: Karina Reiss; Paul Saftig
The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions.
Seminars in cell & developmental biology 2009;20(2):126-37.
2009: Eeva-Liisa Eskelinen; Paul Saftig
Autophagy: a lysosomal degradation pathway with a central role in health and disease.
Biochimica et biophysica acta 2009;1793(4):664-73.
2009: Sylvain M Le Gall; Pierre Bobé; Karina Reiss; Keisuke Horiuchi; Xiao-Da Niu; Daniel Lundell; David R Gibb; Daniel Conrad; Paul Saftig; Carl P Blobel
ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha.
Molecular biology of the cell 2009;20(6):1785-94.
2009: Jenny Schröder; Renate Lüllmann-Rauch; Nina Himmerkus; Irina Pleines; Bernhard Nieswandt; Zane Orinska; Friedrich Koch-Nolte; Bernd Schröder; Markus Bleich; Paul Saftig
Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function.
Molecular and cellular biology 2009;29(4):1083-94.
2009: Tobias Huth; Karoline Schmidt-Neuenfeldt; Andrea Rittger; Paul Saftig; Karina Reiss; Christian Alzheimer
Non-proteolytic effect of beta-site APP-cleaving enzyme 1 (BACE1) on sodium channel function.
Neurobiology of disease 2009;33(2):282-9.
2009: Susan R Wilson; Christoph Peters; Paul Saftig; Dieter Brömme
Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption.
The Journal of biological chemistry 2009;284(4):2584-92.
2009: Valerie Cullen; Maria Lindfors; Juliana Ng; Anders Paetau; Erika Swinton; Piotr Kolodziej; Heather Boston; Paul Saftig; John Woulfe; Mel B Feany; Liisa Myllykangas; Michael G Schlossmacher; Jaana Tyynelä
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.
Molecular brain 2009;2():5.
2008: Judith Blanz; Stijn Stroobants; Renate Lüllmann-Rauch; Willy Morelle; Meike Lüdemann; Rudi D'Hooge; Helena Reuterwall; Jean Claude Michalski; Jens Fogh; Claes Andersson; Paul Saftig
Reversal of peripheral and central neural storage and ataxia after recombinant enzyme replacement therapy in alpha-mannosidosis mice.
Human molecular genetics 2008;17(22):3437-45.
2008: Angela Raucci; Simona Cugusi; Antonella Antonelli; Silvia Barabino; Lucilla Monti; Angelika Bierhaus; Karina Reiss; Paul Saftig; Marco E Bianchi
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3716-27.
2008: Paul Saftig; Eeva-Liisa Eskelinen
Live longer with LAMP-2.
Nature medicine 2008;14(9):909-10.
2008: Andriy O Samokhin; Andre Wong; Paul Saftig; Dieter Brömme
Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice.
Atherosclerosis 2008;200(1):58-68.
2008: Sabrina Jabs; Arne Quitsch; Reijo Kakela; Bettina Koch; Jaana Tyynelä; Helmut Brade; Markus Glatzel; Steven U Walkley; Paul Saftig; marie T vanier; Thomas Braulke
Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis.
Journal of neurochemistry 2008;106(3):1415-25.
2008: May Christine Malicdan; Satoru Noguchi; Ikuya Nonaka; Paul Saftig; Ichizo Nishino
Lysosomal myopathies: an excessive build-up in autophagosomes is too much to handle.
Neuromuscular disorders : NMD 2008;18(7):521-9.
2008: Thorsten Maretzky; Felix Scholz; Bente Köten; Ehrhardt Proksch; Paul Saftig; Karina Reiss
ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis.
The Journal of investigative dermatology 2008;128(7):1737-46.
2008: Burkhard Schulz; Jessica Pruessmeyer; Thorsten Maretzky; Andreas Ludwig; Carl P Blobel; Paul Saftig; Karina Reiss
ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.
Circulation research 2008;102(10):1192-201.
2008: Paul Saftig; Wouter Beertsen; Eeva-Liisa Eskelinen
LAMP-2: a control step for phagosome and autophagosome maturation.
Autophagy 2008;4(4):510-2.
2008: Samuel F Berkovic; Leanne M Dibbens; Alicia Oshlack; Jeremy D Silver; Marina Katerelos; Danya F Vears; Renate Lüllmann-Rauch; Judith Blanz; Ke Wei Zhang; Jim Stankovich; Renate M Kalnins; John P Dowling; Eva Andermann; Frederick Andermann; Enrico Faldini; Rudi D'Hooge; Lata Vadlamudi; Richard A Macdonell; Bree L Hodgson; Marta A Bayly; Judy Savige; John C Mulley; Gordon K Smyth; David A Power; Paul Saftig; Melanie Bahlo
Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis.
American journal of human genetics 2008;82(3):673-84.
2008: Uta Schurigt; Klaus M Hummel; Peter Petrow; Mieczyslaw Gajda; Renate Stöckigt; Peter Middel; Jochen Zwerina; Tobias Janik; Ricardo Bernhardt; Susann Schüler; Dieter Scharnweber; Felix Beckmann; Paul Saftig; george kollias; Georg Schett; Bernd Wiederanders; Rolf Bräuer
Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice.
Arthritis and rheumatism 2008;58(2):422-34.
2008: Masataka Asagiri; Toshitake Hirai; Toshihiro Kunigami; Shunya Kamano; Hans-Jürgen Gober; Kazuo Okamoto; Keizo Nishikawa; Eicke Latz; Douglas T Golenbock; Kazuhiro Aoki; Keiichi Ohya; Yuuki Imai; Yasuyuki Morishita; Kohei Miyazono; Shigeaki Kato; Paul Saftig; Hiroshi Takayanagi
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
Science (New York, N.Y.) 2008;319(5863):624-7.
2008: Lucas Martin; Regina Fluhrer; Karina Reiss; Elisabeth Kremmer; Paul Saftig; Christian Haass
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
The Journal of biological chemistry 2008;283(3):1644-52.
2008: Wouter Beertsen; Marion Willenborg; Vincent Everts; Angelika Zirogianni; Rainer Podschun; Bernd Schröder; Eeva-Liisa Eskelinen; Paul Saftig
Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):475-82.
2008: Sanna Partanen; Aleksi Haapanen; Catherine Kielar; Charles Pontikis; Noreen Alexander; Teija Inkinen; Paul Saftig; Thomas H Gillingwater; Jonathan D Cooper; Jaana Tyynelä
Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis.
Journal of neuropathology and experimental neurology 2008;67(1):16-29.
2007: David Reczek; Michael Schwake; Jenny Schröder; Heather Hughes; Judith Blanz; Xiaoying Jin; William Brondyk; Scott M Van Patten; Tim Edmunds; Paul Saftig
LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase.
Cell 2007;131(4):770-83.
2007: Lionel Apetoh; François Ghiringhelli; Antoine Tesniere; Michel Obeid; Carla Ortiz; Alfredo Criollo; Grégoire Mignot; M Chiara Maiuri; Evelyn Ullrich; Patrick Saulnier; Huan Yang; Sebastian Amigorena; Bernhard RYFFEL; Franck J Barrat; Paul Saftig; Francis Levi; Rosette Lidereau; Catherine Nogues; Jean-Paul Mira; Agnès Chompret; Virginie Joulin; Françoise Clavel-Chapelon; Jean Bourhis; Fabrice André; Suzette Delaloge; Thomas Tursz; Guido Kroemer; Laurence Zitvogel
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.
Nature medicine 2007;13(9):1050-9.
2007: Marcelo G Binker; Laura I Cosen-Binker; Mauricio R Terebiznik; Gustavo V Mallo; Shannon E McCaw; Eeva-Liisa Eskelinen; Marion Willenborg; John H Brumell; Paul Saftig; Sergio Grinstein; Scott D Gray-Owen
Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2.
Cellular microbiology 2007;9(9):2153-66.
2007: Ryo Yamasaki; Jian Zhang; Ichiro Koshiishi; Dewi F Sastradipura Suniarti; Zhou Wu; Christoph Peters; Michael Schwake; Yasuo Uchiyama; Jun-ichi Kira; Paul Saftig; Hideo Utsumi; Hiroshi Nakanishi
Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice.
Molecular and cellular neurosciences 2007;35(4):573-84.
2007: Christian Hundhausen; Alexander Schulte; Beate Schulz; Michael G Andrzejewski; Nicole Schwarz; Philipp von Hundelshausen; Ulrike Winter; Krzysztof Paliga; Karina Reiss; Paul Saftig; Christian Weber; Andreas Ludwig
Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):8064-72.
2007: Blanche Schroen; Joost J Leenders; Arie van Erk; Anne T Bertrand; Mirjam van Loon; Rick E W van Leeuwen; Nard Kubben; Rudy F J J Duisters; Mark Schellings; Ben J A Janssen; Jacques J M Debets; Michael Schwake; Morten A Høydal; Stephane Heymans; Paul Saftig; Yigal M Pinto
Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy.
The Journal of experimental medicine 2007;204(5):1227-35.
2007: Ken C Walls; Barbara J Klocke; Paul Saftig; Masahiro Shibata; Yasuo Uchiyama; Kevin A Roth; John J Shacka
Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain.
Autophagy 2007;3(3):222-9.
2007: Marc Schulte; Karina Reiss; Marcus Lettau; Thorsten Maretzky; Andreas Ludwig; Dieter Hartmann; Bart De Strooper; Ottmar Janssen; Paul Saftig
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death.
Cell death and differentiation 2007;14(5):1040-9.
2007: Christina Wehling; Christian Beimgraben; Christoph Gelhaus; Thomas Friedrich; Paul Saftig; Joachim Grötzinger; Michael Schwake
Self-assembly of the isolated KCNQ2 subunit interaction domain.
FEBS letters 2007;581(8):1594-8.
2007: John J Shacka; Barbara J Klocke; Chainllie Young; Masahiro Shibata; John W Olney; Yasuo Uchiyama; Paul Saftig; Kevin A Roth
Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(8):2081-90.
2007: Nianyu Li; Yao Wang; Karen Forbes; Kate M Vignali; Bret Heale; Paul Saftig; Dieter Hartmann; Roy A Black; John J Rossi; Carl P Blobel; Peter J Dempsey; Creg J Workman; Dario A A Vignali
Metalloproteases regulate T-cell proliferation and effector function via LAG-3.
The EMBO journal 2007;26(2):494-504.
2007: Kassidy K Huynh; Eeva-Liisa Eskelinen; Cameron C Scott; Anatoly Malevanets; Paul Saftig; Sergio Grinstein
LAMP proteins are required for fusion of lysosomes with phagosomes.
The EMBO journal 2007;26(2):313-24.
2007: Calogero Tulone; Yasuo Uchiyama; Marco Novelli; Nicholas Grosvenor; Paul Saftig; Benjamin M Chain
Haematopoietic development and immunological function in the absence of cathepsin D.
BMC immunology 2007;8():22.
2007: Marcella Funicello; Michela Novelli; Maurizio Ragni; Teresa Vottari; Cesare Cocuzza; Joaquin Soriano-Lopez; Chiara Chiellini; Federico Boschi; Pasquina Marzola; Pellegrino Masiello; Paul Saftig; Ferruccio Santini; Rene St-Jacques; Sylvie Desmarais; Nicolas Morin; Joseph Mancini; Michael Percival; Aldo Pinchera; Margherita Maffei
Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores.
PloS one 2007;2(8):e683.
2007: Dennis A Eichenauer; Vijaya Lakshmi Simhadri; Elke Pogge Von Strandmann; Andreas Ludwig; Vance Matthews; Katrin S Reiners; Bastian Von Tresckow; Paul Saftig; Stefan Rose-John; Andreas Engert; Hinrich P Hansen
ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro.
Cancer research 2007;67(1):332-8.
2007: Keisuke Horiuchi; Sylvain Le Gall; Marc Schulte; Takafumi Yamaguchi; Karina Reiss; Gillian Murphy; Yoshiaki Toyama; Dieter Hartmann; Paul Saftig; Carl P Blobel
Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx.
Molecular biology of the cell 2007;18(1):176-88.
2006: Gisela Weskamp; Jill W Ford; Jamie L Sturgill; Steve Martin; Andrew J P Docherty; Steven Swendeman; Neil Broadway; Dieter Hartmann; Paul Saftig; Shelby Umland; Atsuko Sehara-Fujisawa; Roy A Black; Andreas Ludwig; J David Becherer; Daniel H Conrad; Carl P Blobel
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
Nature immunology 2006;7(12):1293-8.
2006: S P M Lutgens; Natasja Kisters; Esther Lutgens; Rachel I M van Haaften; Chris T A Evelo; Menno de Winther; Paul Saftig; Mat J A P Daemen; Sylvia Heeneman; Kitty B J M Cleutjens
Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic.
The Journal of pathology 2006;210(3):334-43.
2006: Michael Willem; Alistair Garratt; Bozidar Novak; Martin Citron; Steve Kaufmann; Andrea Rittger; Bart DeStrooper; Paul Saftig; Carmen Birchmeier; Christian Haass
Control of peripheral nerve myelination by the beta-secretase BACE1.
Science (New York, N.Y.) 2006;314(5799):664-6.
2006: S Perez-Amodio; DC Jansen; Ton Schoenmaker; I M C Vogels; Thomas Reinheckel; Alison R Hayman; Timothy M Cox; Paul Saftig; Wouter Beertsen; Vincent Everts
Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity.
Calcified tissue international 2006;79(4):245-54.
2006: Marlies Knipper; Cathrin Claussen; Lukas Rüttiger; Ulrike Zimmermann; Renate Lüllmann-Rauch; Eeva-Liisa Eskelinen; Jenny Schröder; Michael Schwake; Paul Saftig
Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis.
The Journal of physiology 2006;576(Pt 1):73-86.
2006: Vincent Everts; Wolf Korper; Kees A Hoeben; Ineke D C Jansen; Dieter Bromme; Kitty B J M Cleutjens; Sylvia Heeneman; Christoph Peters; Thomas Reinheckel; Paul Saftig; Wouter Beertsen
Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(9):1399-408.
2006: Karina Reiss; Andreas Ludwig; Paul Saftig
Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion.
Pharmacology & therapeutics 2006;111(3):985-1006.
2006: Karina Reiss; Thorsten Maretzky; Ingrid G Haas; Marc Schulte; Andreas Ludwig; Marcus Frank; Paul Saftig
Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion.
The Journal of biological chemistry 2006;281(31):21735-44.
2006: Karen Caeyenberghs; Detlef Balschun; Diego Prieto Roces; Michael Schwake; Paul Saftig; Rudi D'Hooge
Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment.
Neurobiology of disease 2006;23(2):422-32.
2006: Joan Josep Bech-Serra; Belén Santiago-Josefat; Cary Esselens; Paul Saftig; José Baselga; Joaquín Arribas; Francesc Canals
Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis.
Molecular and cellular biology 2006;26(13):5086-95.
2006: Jörg Stypmann; Paul Janssen; Jürgen Prestle; Markus A Engelen; Harald Kögler; Renate Lüllmann-Rauch; Lars Eckardt; Kurt von Figura; Jobst Landgrebe; Anna Mleczko; Paul Saftig
LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling.
Basic research in cardiology 2006;101(4):281-91.
2006: Robert Steinfeld; Konstanze Reinhardt; Kathrin Schreiber; Merle Hillebrand; Ralph Kraetzner; Wolfgang Bruck; Paul Saftig; Jutta Gartner
Cathepsin D deficiency is associated with a human neurodegenerative disorder.
American journal of human genetics 2006;78(6):988-98.
2006: Lars Anders; Philipp Mertins; Sven Lammich; Marta Murgia; Dieter Hartmann; Paul Saftig; Christian Haass; Axel Ullrich
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity.
Molecular and cellular biology 2006;26(10):3917-34.
2006: Michael Schwake; Despina Athanasiadu; Christian Beimgraben; Judith Blanz; Christian Beck; Thomas J Jentsch; Paul Saftig; Thomas Friedrich
Structural determinants of M-type KCNQ (Kv7) K+ channel assembly.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(14):3757-66.
2006: Elida del Cerro-Vadillo; Fidel Madrazo-Toca; Eugenio Carrasco-Marín; Lorena Fernandez-Prieto; Christian Beck; Francisco Leyva-Cobian; Paul Saftig; Carmen Alvarez-Dominguez
Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1321-5.
2006: Esther Lutgens; S P M Lutgens; Birgit C G Faber; Sylvia Heeneman; M M J Gijbels; Menno de Winther; Peter M Frederik; Ingeborg van der Made; A Daugherty; A M Sijbers; A Fisher; C J Long; Paul Saftig; D Black; Mat J A P Daemen; Kitty B J M Cleutjens
Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation.
Circulation 2006;113(1):98-107.
2005: Masato Koike; Masahiro Shibata; Satoshi Waguri; Kentaro Yoshimura; Isei Tanida; Eiki Kominami; Takahiro Gotow; Christoph Peters; Kurt von Figura; Noboru Mizushima; Paul Saftig; Yasuo Uchiyama
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease).
The American journal of pathology 2005;167(6):1713-28.
2005: Marion Willenborg; Christine Kathrin Schmidt; Peter Braun; Jobst Landgrebe; Kurt von Figura; Paul Saftig; Eeva-Liisa Eskelinen
Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation.
Journal of lipid research 2005;46(12):2559-69.
2005: Vadim Budagian; Elena Bulanova; Zane Orinska; Erwin Duitman; Katja Brandt; Andreas Ludwig; Dieter Hartmann; Greg Lemke; Paul Saftig; Silvia Bulfone-Paus
Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum.
Molecular and cellular biology 2005;25(21):9324-39.
2005: Eeva-Liisa Eskelinen; Ana Maria Cuervo; Matthew R G Taylor; Ichizo Nishino; Janice S Blum; J Fred Dice; Ignacio V Sandoval; Jennifer Lippincott-Schwartz; Thomas August; Paul Saftig
Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2.
Traffic (Copenhagen, Denmark) 2005;6(11):1058-61.
2005: Thorsten Maretzky; Marc Schulte; Andreas Ludwig; Stefan Rose-John; Carl Blobel; Dieter Hartmann; Peter Altevogt; Paul Saftig; Karina Reiss
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth.
Molecular and cellular biology 2005;25(20):9040-53.
2005: Toshio Kuronita; Toshiyuki Hatano; Atsuko Furuyama; Yuko Hirota; Naoko Masuyama; Paul Saftig; Masaru Himeno; Hideaki Fujita; Yoshitaka Tanaka
The NH(2)-terminal transmembrane and lumenal domains of LGP85 are needed for the formation of enlarged endosomes/lysosomes.
Traffic (Copenhagen, Denmark) 2005;6(10):895-906.
2005: Diana-Ines Dominguez; Jos Tournoy; Dieter Hartmann; Tobias Huth; Kim Cryns; Siska Deforce; Lutgarde Serneels; Ira Espuny Camacho; Els Marjaux; Katleen Craessaerts; Anton J M Roebroek; Michael Schwake; Rudi D'Hooge; Patricia Bach; Ulrich Kalinke; Dieder Moechars; Christian Alzheimer; Karina Reiss; Paul Saftig; Bart De Strooper
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.
The Journal of biological chemistry 2005;280(35):30797-806.
2005: Tokiko Shimizu; Yoshinori Hayashi; Ryo Yamasaki; Jun Yamada; Jian Zhang; Kiyoharu Ukai; Masato Koike; Kazunori Mine; Kurt von Figura; Christoph Peters; Paul Saftig; Takaichi Fukuda; Yasuo Uchiyama; Hiroshi Nakanishi
Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice.
Journal of neurochemistry 2005;94(3):680-90.
2005: Rosa-Ana González-Polo; Marian Mellen; Anne-Laure Pauleau; Abdelali JALIL; Nathanael Larochette; Sylvie Souquère; Eeva-Liisa Eskelinen; Gérard Pierron; Paul Saftig; Guido Kroemer
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death.
Journal of cell science 2005;118(Pt 14):3091-102.
2005: Rudi D'Hooge; Renate Lüllmann-Rauch; Tom Beckers; Detlef Balschun; Michael Schwake; Karina Reiss; Kurt von Figura; Paul Saftig
Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(28):6539-49.
2005: Thorsten Maretzky; Karina Reiss; Andreas Ludwig; Julian Buchholz; Felix Scholz; Ehrhardt Proksch; Bart De Strooper; Dieter Hartmann; Paul Saftig
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9182-7.
2005: Hon Kit Wong; Takashi Sakurai; Fumitaka Oyama; Kumi Kaneko; Koji Wada; Haruko Miyazaki; Masaru Kurosawa; Bart De Strooper; Paul Saftig; Nobuyuki Nukina
beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase.
The Journal of biological chemistry 2005;280(24):23009-17.
2005: Kazuma Sugie; Satoru Noguchi; Yoshimichi Kozuka; Eri Arikawa-Hirasawa; Mikihito Tanaka; Chuanzhu Yan; Paul Saftig; Kurt von Figura; Michio Hirano; Satoshi Ueno; Ikuya Nonaka; Ichizo Nishino
Autophagic vacuoles with sarcolemmal features delineate Danon disease and related myopathies.
Journal of neuropathology and experimental neurology 2005;64(6):513-22.
2005: Anne Schenzer; Thomas Friedrich; Michael Pusch; Paul Saftig; Thomas J Jentsch; Joachim Grötzinger; Michael Schwake
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(20):5051-60.
2005: Frida Henningsson; Kenji Yamamoto; Paul Saftig; Thomas Reinheckel; Christoph Peters; Stefan D Knight; Gunnar Pejler
A role for cathepsin E in the processing of mast-cell carboxypeptidase A.
Journal of cell science 2005;118(Pt 9):2035-42.
2005: Karina Reiss; Thorsten Maretzky; Andreas Ludwig; Thomas Tousseyn; Bart De Strooper; Dieter Hartmann; Paul Saftig
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling.
The EMBO journal 2005;24(4):742-52.
2004: Gil G Westmeyer; Michael Willem; Stefan F Lichtenthaler; Glenn Lurman; Gerd Multhaup; Irmgard Assfalg-Machleidt; Karina Reiss; Paul Saftig; Christian Haass
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.
The Journal of biological chemistry 2004;279(51):53205-12.
2004: Werner Kilb; Dieter Hartmann; Paul Saftig; Heiko J Luhmann
Altered morphological and electrophysiological properties of Cajal-Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout mice.
The European journal of neuroscience 2004;20(10):2749-56.
2004: Emmanuel Godat; Fabien Lecaille; Claire Desmazes; Sophie Duchêne; Enrico Weidauer; Paul Saftig; Dieter Brömme; Christophe Vandier; Gilles Lalmanach
Cathepsin K: a cysteine protease with unique kinin-degrading properties.
The Biochemical journal 2004;383(Pt. 3):501-6.
2004: Yufang Zheng; Paul Saftig; Dieter Hartmann; Carl P Blobel
Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17).
The Journal of biological chemistry 2004;279(41):42898-906.
2004: Cary Esselens; Viola Oorschot; Veerle Baert; Tim Raemaekers; Kurt Spittaels; Lutgarde Serneels; Hui Zheng; Paul Saftig; Bart De Strooper; Judith Klumperman; Willem ANNAERT
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.
The Journal of cell biology 2004;166(7):1041-54.
2004: Vadim Budagian; Elena Bulanova; Zane Orinska; Andreas Ludwig; Stefan Rose-John; Paul Saftig; Ernest C Borden; Silvia Bulfone-Paus
Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).
The Journal of biological chemistry 2004;279(39):40368-75.
2004: Stefanie Jäger; Cecilia Bucci; Isei Tanida; Takashi Ueno; Eiki Kominami; Paul Saftig; Eeva-Liisa Eskelinen
Role for Rab7 in maturation of late autophagic vacuoles.
Journal of cell science 2004;117(Pt 20):4837-48.
2004: Diego Prieto Roces; Renate Lüllmann-Rauch; Jianhe Peng; Chiara Balducci; Claes Andersson; Ole Tollersrud; Jens Fogh; Antonio Orlacchio; Tommaso Beccari; Paul Saftig; Kurt von Figura
Efficacy of enzyme replacement therapy in alpha-mannosidosis mice: a preclinical animal study.
Human molecular genetics 2004;13(18):1979-88.
2004: Aline Wille; Annegret Gerber; Anke Heimburg; Anita Reisenauer; Christoph Peters; Paul Saftig; Thomas Reinheckel; Tobias Welte; Frank Bühling
Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells.
Biological chemistry 2004;385(7):665-70.
2004: Jos Tournoy; Xavier Bossuyt; An Snellinx; Marleen Regent; Marian Garmyn; Lutgarde Serneels; Paul Saftig; Katleen Craessaerts; Bart De Strooper; Dieter Hartmann
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.
Human molecular genetics 2004;13(13):1321-31.
2004: Eeva-Liisa Eskelinen; Christine Katrin Schmidt; Silja Neu; Marion Willenborg; Graciela Fuertes; Natalia Salvador; Yoshitaka Tanaka; Renate Lüllmann-Rauch; Dieter Hartmann; Jörg Heeren; Kurt von Figura; Erwin Knecht; Paul Saftig
Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts.
Molecular biology of the cell 2004;15(7):3132-45.
2004: Osamu Nagano; Daizo Murakami; Dieter Hartmann; Bart De Strooper; Paul Saftig; Takeshi Iwatsubo; Motowo Nakajima; Masanori Shinohara; Hideyuki Saya
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation.
The Journal of cell biology 2004;165(6):893-902.
2004: Frank Bühling; Christoph Röcken; Frank Brasch; Roland Hartig; Yoshiyuki Yasuda; Paul Saftig; Dieter Brömme; Tobias Welte
Pivotal role of cathepsin K in lung fibrosis.
The American journal of pathology 2004;164(6):2203-16.
2004: Soeren Abel; Christian Hundhausen; Rolf Mentlein; Alexander Schulte; Theo A Berkhout; Neil Broadway; Dieter Hartmann; Radislav Sedlacek; Sebastian Dietrich; Barbara Muetze; Björn Schuster; Karl-Josef Kallen; Paul Saftig; Stefan Rose-John; Andreas Ludwig
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6362-72.
2004: Friederike Egberts; Michael Heinrich; Jens-Michael Jensen; Supandi Winoto-Morbach; Stephan Pfeiffer; Marc Wickel; Michael Schunck; Judith Steude; Paul Saftig; Ehrhardt Proksch; Stefan Schütze
Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation.
Journal of cell science 2004;117(Pt 11):2295-307.
2004: Umut Sahin; Gisela Weskamp; Kristine Kelly; Hong-Ming Zhou; Shigeki Higashiyama; Jacques J Peschon; Dieter Hartmann; Paul Saftig; Carl P Blobel
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.
The Journal of cell biology 2004;164(5):769-79.
2004: Gisela Weskamp; Johannes Schlöndorff; Lawrence Lum; J David Becherer; TAE-WAN KIM; Paul Saftig; Dieter Hartmann; Gillian Murphy; Carl P Blobel
Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).
The Journal of biological chemistry 2004;279(6):4241-9.
2003: Stefan F Lichtenthaler; Diana-Ines Dominguez; Gil G Westmeyer; Karina Reiss; Christian Haass; Paul Saftig; Bart De Strooper; Brian Seed
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
The Journal of biological chemistry 2003;278(49):48713-9.
2003: Vance Matthews; Björn Schuster; Stefan Schütze; Ingo Bussmeyer; Andreas Ludwig; Christian Hundhausen; Thorsten Sadowski; Paul Saftig; Dieter Hartmann; Karl-Josef Kallen; Stefan Rose-John
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).
The Journal of biological chemistry 2003;278(40):38829-39.
2003: Vincent Everts; Wu-Shiun Hou; X Rialland; W Tigchelaar; Paul Saftig; Dieter Brömme; Bruce D Gelb; Wouter Beertsen
Cathepsin K deficiency in pycnodysostosis results in accumulation of non-digested phagocytosed collagen in fibroblasts.
Calcified tissue international 2003;73(4):380-6.
2003: Christian Hundhausen; Dominika Misztela; Theo A Berkhout; Neil Broadway; Paul Saftig; Karina Reiss; Dieter Hartmann; Falk Fahrenholz; Rolf Postina; Vance Matthews; Karl-Josef Kallen; Stefan Rose-John; Andreas Ludwig
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Blood 2003;102(4):1186-95.
2003: Bianca Friedrichs; Carmen Tepel; Thomas Reinheckel; Jan M Deussing; Kurt von Figura; Volker Herzog; Christoph Peters; Paul Saftig; Klaudia Brix
Thyroid functions of mouse cathepsins B, K, and L.
The Journal of clinical investigation 2003;111(11):1733-45.
2003: Alexander-Christian Gamp; Yoshitaka Tanaka; Renate Lüllmann-Rauch; Dorothee Wittke; Rudi D'Hooge; Peter Paul De Deyn; Tobias Moser; Hannes Maier; Dieter Hartmann; Karina Reiss; Anna-Lena Illert; Kurt von Figura; Paul Saftig
LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice.
Human molecular genetics 2003;12(6):631-46.
2003: Eeva-Liisa Eskelinen; Yoshitaka Tanaka; Paul Saftig
At the acidic edge: emerging functions for lysosomal membrane proteins.
Trends in cell biology 2003;13(3):137-45.
2003: Masato Koike; Masahiro Shibata; Yoshiyuki Ohsawa; Hiroshi Nakanishi; Tomoyuki Koga; Satoshi Kametaka; Satoshi Waguri; Takashi Momoi; Eiki Kominami; Christoph Peters; Kurt von Figura; Paul Saftig; Yasuo Uchiyama
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice.
Molecular and cellular neurosciences 2003;22(2):146-61.
2003: Jacques P M Schellens; Paul Saftig; Kurt von Figura; Vincent Everts
Deficiency of mannose 6-phosphate receptors and lysosomal storage: a morphometric analysis of hepatocytes of neonatal mice.
Cell biology international 2003;27(11):897-902.
2002: Toshio Kuronita; Eeva-Liisa Eskelinen; Hideaki Fujita; Paul Saftig; Masaru Himeno; Yoshitaka Tanaka
A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology.
Journal of cell science 2002;115(Pt 21):4117-31.
2002: Dieter Hartmann; Bart De Strooper; Lutgarde Serneels; Katleen Craessaerts; An Herreman; Willem ANNAERT; Lieve Umans; Torben Lübke; Anna Lena Illert; Kurt von Figura; Paul Saftig
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Human molecular genetics 2002;11(21):2615-24.
2002: Eeva-Liisa Eskelinen; Anna Lena Illert; Yoshitaka Tanaka; Günter Schwarzmann; Judith Blanz; Kurt von Figura; Paul Saftig
Role of LAMP-2 in lysosome biogenesis and autophagy.
Molecular biology of the cell 2002;13(9):3355-68.
2002: Omar Nyabi; Stefan Pype; Marc Mercken; An Herreman; Paul Saftig; Katleen Craessaerts; Lutgarde Serneels; Willem ANNAERT; Bart De Strooper
No endogenous A beta production in presenilin-deficient fibroblasts.
Nature cell biology 2002;4(7):E164; author reply E165-6.
2002: Malcolm Leissring; Michael Murphy; Tonya R Mead; Yama Akbari; Michael C Sugarman; Mehrdad Jannatipour; Brigitte Anliker; Ulrike Müller; Paul Saftig; Bart De Strooper; Michael S Wolfe; todd golde; Frank M LaFerla
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4697-702.
2002: Tsuyoshi Nishioku; Koichi Hashimoto; Keizo Yamashita; Shyh-Yuh Liou; Yoshifumi Kagamiishi; Hitoshi Maegawa; Nobuo Katsube; Christoph Peters; Kurt von Figura; Paul Saftig; Nobuhiko Katunuma; Kenji Yamamoto; Hiroshi Nakanishi
Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia.
The Journal of biological chemistry 2002;277(7):4816-22.
2002: Olaf Zwad; Bernd Kübler; Wera Roth; Jens-Gerd Scharf; Paul Saftig; Christof Peters; Thomas Braulke
Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts.
FEBS letters 2002;510(3):211-5.
2002: Vincent Everts; Jean-Marie Delaissé; Wolf Korper; DC Jansen; Wikky Tigchelaar-Gutter; Paul Saftig; Wouter Beertsen
The bone lining cell: its role in cleaning Howship's lacunae and initiating bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(1):77-90.
2001: A Suter; Vincent Everts; A Boyde; S J Jones; Renate Lüllmann-Rauch; Dieter Hartmann; Alison R Hayman; Timothy M Cox; Martin J Evans; T Meister; Kurt von Figura; Paul Saftig
Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice.
Development (Cambridge, England) 2001;128(23):4899-910.
2001: Jens Wiltfang; Hermann Esselmann; P Cupers; M Neumann; Hans A Kretzschmar; M Beyermann; D Schleuder; Holger Jahn; E Rüther; J Kornhuber; Willem ANNAERT; Bart De Strooper; Paul Saftig
Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.
The Journal of biological chemistry 2001;276(46):42645-57.
2001: Dieter Hartmann; Jos Tournoy; Paul Saftig; Willem ANNAERT; Bart De Strooper
Implication of APP secretases in notch signaling.
Journal of molecular neuroscience : MN 2001;17(2):171-81.
2001: Hiroshi Nakanishi; Jian Zhang; M Koike; Tsuyoshi Nishioku; Yoshiko Okamoto; Eiki Kominami; Kurt von Figura; Christoph Peters; Kenji Yamamoto; Paul Saftig; Yasuo Uchiyama
Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(19):7526-33.
2001: P Cupers; Mostafa Bentahir; Katleen Craessaerts; IC Orlans; hugo vanderstichele; Paul Saftig; Bart De Strooper; Willem ANNAERT
The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
The Journal of cell biology 2001;154(4):731-40.
2001: Paul Saftig; Yoshitaka Tanaka; Renate Lüllmann-Rauch; Kurt von Figura
Disease model: LAMP-2 enlightens Danon disease.
Trends in molecular medicine 2001;7(1):37-9.
2000: Wera Roth; Jan M Deussing; V A Botchkarev; M Pauly-Evers; Paul Saftig; A Hafner; P Schmidt; Wolfgang Schmahl; J Scherer; I Anton-Lamprecht; Kurt von Figura; R Paus; Christoph Peters
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(13):2075-86.
2000: Masato Koike; Hiroshi Nakanishi; Paul Saftig; Junji Ezaki; K Isahara; Yoshiyuki Ohsawa; W Schulz-Schaeffer; Tsuyoshi Watanabe; Satoshi Waguri; Satoshi Kametaka; Masahiro Shibata; K Yamamoto; Eiki Kominami; Christoph Peters; Kurt von Figura; Yasuo Uchiyama
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(18):6898-906.
2000: Yoshitaka Tanaka; G Guhde; A Suter; Eeva-Liisa Eskelinen; Dieter Hartmann; Renate Lüllmann-Rauch; Paul Janssen; J Blanz; Kurt von Figura; Paul Saftig
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice.
Nature 2000;406(6798):902-6.
2000: C Meyer; D Zizioli; S Lausmann; Eeva-Liisa Eskelinen; J Hamann; Paul Saftig; Kurt von Figura; Peter Schu
mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors.
The EMBO journal 2000;19(10):2193-203.
2000: Willem ANNAERT; P Cupers; Paul Saftig; Bart De Strooper
Presenilin function in APP processing.
Annals of the New York Academy of Sciences 2000;920():158-64.
2000: Michael Heinrich; Marc Wickel; Supandi Winoto-Morbach; Wulf Schneider-Brachert; Thomas Weber; J Brunner; Paul Saftig; C Peters; Martin Krönke; Stefan Schütze
Ceramide as an activator lipid of cathepsin D.
Advances in experimental medicine and biology 2000;477():305-15.
2000: Paul Saftig; E Hunziker; Vincent Everts; S Jones; A Boyde; O Wehmeyer; A Suter; Kurt von Figura
Functions of cathepsin K in bone resorption. Lessons from cathepsin K deficient mice.
Advances in experimental medicine and biology 2000;477():293-303.
1999: William Ray; M Yao; Jeff S. Mumm; Eric H Schroeter; Paul Saftig; Michael S Wolfe; Dennis J Selkoe; Raphael Kopan; Alison Goate
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.
The Journal of biological chemistry 1999;274(51):36801-7.
1999: José Villadangos; RA Bryant; Jan M Deussing; Christoph Driessen; Ana-Maria Lennon-Duménil; Richard J Riese; Wera Roth; Paul Saftig; Guo-Ping Shi; Harold A Chapman; Christoph Peters; Hidde L Ploegh
Proteases involved in MHC class II antigen presentation.
Immunological reviews 1999;172():109-20.
1999: An Herreman; Dieter Hartmann; Willem ANNAERT; Paul Saftig; Katleen Craessaerts; Lutgarde Serneels; Lieve Umans; V Schrijvers; F Checler; hugo vanderstichele; Veerle Baekelandt; R Dressel; P Cupers; Danny Huylebroeck; An Zwijsen; Fred Van Leuven; Bart De Strooper
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11872-7.
1999: Michael Heinrich; Marc Wickel; Wulf Schneider-Brachert; C Sandberg; J Gahr; R Schwandner; Thomas Weber; Paul Saftig; C Peters; J Brunner; Martin Krönke; Stefan Schütze
Cathepsin D targeted by acid sphingomyelinase-derived ceramide.
The EMBO journal 1999;18(19):5252-63.
1999: S Stinchi; Renate Lüllmann-Rauch; Dieter Hartmann; R Coenen; Tommaso Beccari; Antonio Orlacchio; Kurt von Figura; Paul Saftig
Targeted disruption of the lysosomal alpha-mannosidase gene results in mice resembling a mild form of human alpha-mannosidosis.
Human molecular genetics 1999;8(8):1365-72.
1999: Dieter Hartmann; Bart De Strooper; Paul Saftig
Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly.
Current biology : CB 1999;9(14):719-27.
1999: N Andrejewski; E L Punnonen; G Guhde; Yoshitaka Tanaka; Renate Lüllmann-Rauch; Dieter Hartmann; Kurt von Figura; Paul Saftig
Normal lysosomal morphology and function in LAMP-1-deficient mice.
The Journal of biological chemistry 1999;274(18):12692-701.
1999: Bart De Strooper; Willem ANNAERT; P Cupers; Paul Saftig; Katleen Craessaerts; Jeff S. Mumm; Eric H Schroeter; V Schrijvers; Michael S Wolfe; William Ray; Alison Goate; Raphael Kopan
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Nature 1999;398(6727):518-22.
1999: D Zizioli; C Meyer; G Guhde; Paul Saftig; Kurt von Figura; Peter Schu
Early embryonic death of mice deficient in gamma-adaptin.
The Journal of biological chemistry 1999;274(9):5385-90.
1999: Paul Saftig; Dieter Hartmann; Bart De Strooper
The function of presenilin-1 in amyloid beta-peptide generation and brain development.
European archives of psychiatry and clinical neuroscience 1999;249(6):271-9.
1998: Paul Saftig; E Hunziker; O Wehmeyer; S Jones; A Boyde; W Rommerskirch; J D Moritz; P Schu; Kurt von Figura
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13453-8.
1998: Paul Saftig; Bart De Strooper
Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes.
Molecular psychiatry 1998;3(4):287-9.
1998: Jan M Deussing; Wera Roth; Paul Saftig; Christoph Peters; Hidde L Ploegh; José Villadangos
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4516-21.
1998: Bart De Strooper; Paul Saftig; Katleen Craessaerts; hugo vanderstichele; G Guhde; Willem ANNAERT; Kurt von Figura; Fred Van Leuven
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
Nature 1998;391(6665):387-90.
1997: Joachim R Wolff; W L Liu; H Böttcher; István A Krizbai; F Jóo; Paul Saftig; A Parducz
Non-conventional role of lysosomal acid phosphatase in olfactory receptor axons: co-localization with growth-associated phosphoprotein-43.
Neuroscience 1997;79(3):887-91.
1997: Paul Saftig; Dieter Hartmann; Renate Lüllmann-Rauch; J Wolff; M Evers; A Köster; Michal Hetman; Kurt von Figura; Christoph Peters
Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system.
The Journal of biological chemistry 1997;272(30):18628-35.
1996: B Hess; Paul Saftig; Dieter Hartmann; R Coenen; Renate Lüllmann-Rauch; H H Goebel; M Evers; Kurt von Figura; Rudi D'Hooge; Guy Nagels; Peter Paul De Deyn; Christoph Peters; Volkmar Gieselmann
Phenotype of arylsulfatase A-deficient mice: relationship to human metachromatic leukodystrophy.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14821-6.
1996: Paul Saftig; Christoph Peters; Kurt von Figura; Katleen Craessaerts; Fred Van Leuven; Bart De Strooper
Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.
The Journal of biological chemistry 1996;271(44):27241-4.
1996: M Evers; Paul Saftig; P Schmidt; A Hafner; D B McLoghlin; Wolfgang Schmahl; B Hess; Kurt von Figura; Christoph Peters
Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VI.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8214-9.
1995: Paul Saftig; Michal Hetman; Wolfgang Schmahl; K Weber; L Heine; H Mossmann; A Köster; B Hess; M Evers; Kurt von Figura
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.
The EMBO journal 1995;14(15):3599-608.
1995: Thomas Braulke; Maike Claussen; Paul Saftig; M Wendland; K Neifer; Bernhard Schmidt; J Zapf; Kurt von Figura; Christoph Peters
Proteolysis of IGFBPs by cathepsin D in vitro and in cathepsin D-deficient mice.
Progress in growth factor research 1995;6(2-4):265-71.
1994: Michal Hetman; A Perschl; Paul Saftig; Kurt von Figura; Christoph Peters
Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.
DNA and cell biology 1994;13(4):419-27.
1993: A Köster; Paul Saftig; U Matzner; Kurt von Figura; Christoph Peters; Regina Pohlmann
Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins.
The EMBO journal 1993;12(13):5219-23.