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Ikuko Sagami

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Marketa Miksanova; Jotaro Igarashi; Masahiro Minami; Ikuko Sagami; Seigo Yamauchi; hirofumi kurokawa; Toru Shimizu
Characterization of heme-regulated eIF2alpha kinase: roles of the N-terminal domain in the oligomeric state, heme binding, catalysis, and inhibition.
Yuji Mukaiyama; Takeshi Uchida; Emiko Sato; Ai Sasaki; Yuko Sato; Jotaro Igarashi; hirofumi kurokawa; Ikuko Sagami; Teizo Kitagawa; Toru Shimizu
Spectroscopic and DNA-binding characterization of the isolated heme-bound basic helix-loop-helix-PAS-A domain of neuronal PAS protein 2 (NPAS2), a transcription activator protein associated with circadian rhythms.
Tokiko Yoshimura-Suzuki; Ikuko Sagami; Nao Yokota; hirofumi kurokawa; Toru Shimizu
DOS(Ec), a heme-regulated phosphodiesterase, plays an important role in the regulation of the cyclic AMP level in Escherichia coli.

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2006: Marketa Miksanova; Jotaro Igarashi; Masahiro Minami; Ikuko Sagami; Seigo Yamauchi; hirofumi kurokawa; Toru Shimizu
Characterization of heme-regulated eIF2alpha kinase: roles of the N-terminal domain in the oligomeric state, heme binding, catalysis, and inhibition.
Biochemistry 2006;45(32):9894-905.
2006: Yuji Mukaiyama; Takeshi Uchida; Emiko Sato; Ai Sasaki; Yuko Sato; Jotaro Igarashi; hirofumi kurokawa; Ikuko Sagami; Teizo Kitagawa; Toru Shimizu
Spectroscopic and DNA-binding characterization of the isolated heme-bound basic helix-loop-helix-PAS-A domain of neuronal PAS protein 2 (NPAS2), a transcription activator protein associated with circadian rhythms.
The FEBS journal 2006;273(11):2528-39.
2005: Tokiko Yoshimura-Suzuki; Ikuko Sagami; Nao Yokota; hirofumi kurokawa; Toru Shimizu
DOS(Ec), a heme-regulated phosphodiesterase, plays an important role in the regulation of the cyclic AMP level in Escherichia coli.
Journal of bacteriology 2005;187(19):6678-82.
2005: Ryoji Koudo; hirofumi kurokawa; Emiko Sato; Jotaro Igarashi; Takeshi Uchida; Ikuko Sagami; Teizo Kitagawa; Toru Shimizu
Spectroscopic characterization of the isolated heme-bound PAS-B domain of neuronal PAS domain protein 2 associated with circadian rhythms.
The FEBS journal 2005;272(16):4153-62.
2005: Tokiko Yoshimura-Suzuki; Sasakura Yukie; Ikuko Sagami; Toru Shimizu
[A redox sensing heme-protein from Escherichia coli, Ec DOS: regulation mechanism of phosphodiesterase activity].
Seikagaku. The Journal of Japanese Biochemical Society 2005;77(2):129-33.
2004: Emiko Sato; Ikuko Sagami; Takeshi Uchida; Akira Sato; Teizo Kitagawa; Jotaro Igarashi; Toru Shimizu
SOUL in mouse eyes is a new hexameric heme-binding protein with characteristic optical absorption, resonance Raman spectral, and heme-binding properties.
Biochemistry 2004;43(44):14189-98.
2004: Miki Watanabe; hirofumi kurokawa; Tokiko Yoshimura-Suzuki; Ikuko Sagami; Toru Shimizu
Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control.
European journal of biochemistry / FEBS 2004;271(19):3937-42.
2004: Simona Bengea; Yasuyuki Araki; Osamu Ito; Jotaro Igarashi; Ikuko Sagami; Toru Shimizu
Analysis of the kinetics of CO binding to neuronal nitric oxide synthase by flash photolysis: dual effects of substrates, inhibitors, and tetrahydrobiopterin.
Journal of inorganic biochemistry 2004;98(7):1210-6.
2004: hirofumi kurokawa; Dong-Sun Lee; Miki Watanabe; Ikuko Sagami; Bunzo Mikami; C.S. Raman; Toru Shimizu
A redox-controlled molecular switch revealed by the crystal structure of a bacterial heme PAS sensor.
The Journal of biological chemistry 2004;279(19):20186-93.
2004: Jotaro Igarashi; Akira Sato; Teizo Kitagawa; Tetsuhiko Yoshimura; Seigo Yamauchi; Ikuko Sagami; Toru Shimizu
Activation of heme-regulated eukaryotic initiation factor 2alpha kinase by nitric oxide is induced by the formation of a five-coordinate NO-heme complex: optical absorption, electron spin resonance, and resonance raman spectral studies.
The Journal of biological chemistry 2004;279(16):15752-62.
2004: Yuko Sato; Ikuko Sagami; Toru Shimizu
Identification of caveolin-1-interacting sites in neuronal nitric-oxide synthase. Molecular mechanism for inhibition of NO formation.
The Journal of biological chemistry 2004;279(10):8827-36.
2004: Sue Taguchi; Toshitaka Matsui; Jotaro Igarashi; Sasakura Yukie; Yasuyuki Araki; Osamu Ito; Shunpei Sugiyama; Ikuko Sagami; Toru Shimizu
Binding of oxygen and carbon monoxide to a heme-regulated phosphodiesterase from Escherichia coli. Kinetics and infrared spectra of the full-length wild-type enzyme, isolated PAS domain, and Met-95 mutants.
The Journal of biological chemistry 2004;279(5):3340-7.
2003: Tokiko Yoshimura; Ikuko Sagami; Sasakura Yukie; Toru Shimizu
Relationships between heme incorporation, tetramer formation, and catalysis of a heme-regulated phosphodiesterase from Escherichia coli: a study of deletion and site-directed mutants.
The Journal of biological chemistry 2003;278(52):53105-11.
2003: Satoshi Hirata; Toshitaka Matsui; Sasakura Yukie; Shunpei Sugiyama; Tokiko Yoshimura; Ikuko Sagami; Toru Shimizu
Characterization of Met95 mutants of a heme-regulated phosphodiesterase from Escherichia coli. Optical absorption, magnetic circular dichroism, circular dichroism, and redox potentials.
European journal of biochemistry / FEBS 2003;270(23):4771-9.
2003: Jotaro Igarashi; Akira Sato; Teizo Kitagawa; Ikuko Sagami; Toru Shimizu
CO binding study of mouse heme-regulated eIF-2alpha kinase: kinetics and resonance Raman spectra.
Biochimica et biophysica acta 2003;1650(1-2):99-104.
2003: Ikuko Sagami; Yuko Sato; Toru Shimizu
[Structure-function relationships of NO synthase: electron transfer reaction].
Seikagaku. The Journal of Japanese Biochemical Society 2003;75(5):351-8.
2003: Jyoti Yadav; Ikuko Sagami; Toru Shimizu
Cyanide binding study of neuronal nitric oxide synthase: effects of inhibitors and mutations at the substrate binding site.
Journal of inorganic biochemistry 2003;95(1):25-30.
2003: Simona Bengea; Ikuko Sagami; Toru Shimizu
CO binding to the isolated oxygenase domain of neuronal nitric oxide synthase: effects of inhibitors and mutations at the substrate-binding site.
Journal of inorganic biochemistry 2003;94(4):343-7.
2002: Miki Watanabe; Toshitaka Matsui; Sasakura Yukie; Ikuko Sagami; Toru Shimizu
Unusual cyanide bindings to a heme-regulated phosphodiesterase from Escherichia coli: effect of Met95 mutations.
Biochemical and biophysical research communications 2002;299(2):169-72.
2002: Shigeyoshu Fuziwara; Ikuko Sagami; Elena A Rozhkova; Daniel Craig; Michael A Noble; Andrew W Munro; Stephen K Chapman; Toru Shimizu
Catalytically functional flavocytochrome chimeras of P450 BM3 and nitric oxide synthase.
Journal of inorganic biochemistry 2002;91(4):515-26.
2002: Akira Sato; Sasakura Yukie; Shunpei Sugiyama; Ikuko Sagami; Toru Shimizu; Yasuhisa Mizutani; Teizo Kitagawa
Stationary and time-resolved resonance Raman spectra of His77 and Met95 mutants of the isolated heme domain of a direct oxygen sensor from Escherichia coli.
The Journal of biological chemistry 2002;277(36):32650-8.
2002: Sasakura Yukie; Satoshi Hirata; Shunpei Sugiyama; Shingo Suzuki; Sue Taguchi; Miki Watanabe; Toshitaka Matsui; Ikuko Sagami; Toru Shimizu
Characterization of a direct oxygen sensor heme protein from Escherichia coli. Effects of the heme redox states and mutations at the heme-binding site on catalysis and structure.
The Journal of biological chemistry 2002;277(26):23821-7.
2002: Elena A Rozhkova; Norikazu Fujimoto; Ikuko Sagami; Simon Daff; Toru Shimizu
Interactions between the isolated oxygenase and reductase domains of neuronal nitric-oxide synthase: assessing the role of calmodulin.
The Journal of biological chemistry 2002;277(19):16888-94.
2001: Yuko Sato; Ikuko Sagami; Toru Shimizu
Critical role of the neuronal nitric-oxide synthase heme proximal side residue, Arg418, in catalysis and electron transfer.
Journal of inorganic biochemistry 2001;87(4):261-6.
2001: Kazuo Kobayashi; Seiichi Tagawa; Simon Daff; Ikuko Sagami; T Shimizu
Rapid calmodulin-dependent interdomain electron transfer in neuronal nitric-oxide synthase measured by pulse radiolysis.
The Journal of biological chemistry 2001;276(43):39864-71.
2001: Ikuko Sagami; Simon Daff; Toru Shimizu
Intra-subunit and inter-subunit electron transfer in neuronal nitric-oxide synthase: effect of calmodulin on heterodimer catalysis.
The Journal of biological chemistry 2001;276(32):30036-42.
2001: Simon Daff; Michael A Noble; Daniel H Craig; Stuart L Rivers; Stephen K Chapman; Andrew W Munro; S Fujiwara; Elena A Rozhkova; Ikuko Sagami; Toru Shimizu
Control of electron transfer in neuronal NO synthase.
Biochemical Society transactions 2001;29(Pt 2):147-52.
2001: T Noguchi; Ikuko Sagami; Simon Daff; T Shimizu
Important role of tetrahydrobiopterin in no complex formation and interdomain electron transfer in neuronal nitric-oxide synthase.
Biochemical and biophysical research communications 2001;282(5):1092-7.
2001: Y Sato; Ikuko Sagami; T Matsui; T Shimizu
Unusual role of Tyr588 of neuronal nitric oxide synthase in controlling substrate specificity and electron transfer.
Biochemical and biophysical research communications 2001;281(3):621-6.
2000: T Yumoto; Ikuko Sagami; Simon Daff; T Shimizu
Roles of the heme proximal side residues tryptophan409 and tryptophan421 of neuronal nitric oxide synthase in the electron transfer reaction.
Journal of inorganic biochemistry 2000;82(1-4):163-70.
2000: M Miyajima; Ikuko Sagami; Simon Daff; C Taiko Migita; T Shimizu
Azo reduction of methyl red by neuronal nitric oxide synthase: the important role of FMN in catalysis.
Biochemical and biophysical research communications 2000;275(3):752-8.
2000: Ikuko Sagami; Y Sato; Simon Daff; T Shimizu
Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH.
The Journal of biological chemistry 2000;275(34):26150-7.
1999: Michael A Noble; Andrew W Munro; Stuart L Rivers; L Robledo; Simon Daff; Lesley J Yellowlees; Toru Shimizu; Ikuko Sagami; J G Guillemette; Stephen K Chapman
Potentiometric analysis of the flavin cofactors of neuronal nitric oxide synthase.
Biochemistry 1999;38(50):16413-8.
1999: Simon Daff; Ikuko Sagami; T Shimizu
The 42-amino acid insert in the FMN domain of neuronal nitric-oxide synthase exerts control over Ca(2+)/calmodulin-dependent electron transfer.
The Journal of biological chemistry 1999;274(43):30589-95.
1999: T Shimanuki; H Sato; Simon Daff; Ikuko Sagami; T Shimizu
Crucial role of Lys(423) in the electron transfer of neuronal nitric-oxide synthase.
The Journal of biological chemistry 1999;274(38):26956-61.
1999: Tsuyoshi Kuzuguchi; Y Morita; Ikuko Sagami; Hiroshi Sagami; K Ogura
Human geranylgeranyl diphosphate synthase. cDNA cloning and expression.
The Journal of biological chemistry 1999;274(9):5888-94.
1998: H Sato; Ikuko Sagami; Simon Daff; T Shimizu
Autoxidation rates of neuronal nitric oxide synthase: effects of the substrates, inhibitors, and modulators.
Biochemical and biophysical research communications 1998;253(3):845-9.
1998: K Yanagita; Ikuko Sagami; Simon Daff; T Shimizu
Marked enhancement in the reductive dehalogenation of hexachloroethane by a Thr319Ala mutation of cytochrome P450 1A2.
Biochemical and biophysical research communications 1998;249(3):678-82.
1998: K Nakano; Ikuko Sagami; Simon Daff; T Shimizu
Chiral recognition at the heme active site of nitric oxide synthase is markedly enhanced by L-arginine and 5,6,7,8-tetrahydrobiopterin.
Biochemical and biophysical research communications 1998;248(3):767-72.
1998: H Sato; S Nomura; Ikuko Sagami; O Ito; Simon Daff; T Shimizu
CO binding studies of nitric oxide synthase: effects of the substrate, inhibitors and tetrahydrobiopterin.
FEBS letters 1998;430(3):377-80.
1998: Ikuko Sagami; T Shimizu
The crucial roles of Asp-314 and Thr-315 in the catalytic activation of molecular oxygen by neuronal nitric-oxide synthase. A site-directed mutagenesis study.
The Journal of biological chemistry 1998;273(4):2105-8.
1997: Y Shibata; H Sato; Ikuko Sagami; T Shimizu
Interaction of Angeli's salt with cytochrome P450 1A2 distal mutants: an optical absorption spectral study.
Biochimica et biophysica acta 1997;1343(1):67-75.
1997: K Yanagita; Ikuko Sagami; T Shimizu
Distal site and surface mutations of cytochrome P450 1A2 markedly enhance dehalogenation of chlorinated hydrocarbons.
Archives of biochemistry and biophysics 1997;346(2):269-76.