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Kenji Sagawa

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Rena Nishizawa; Kenji Sagawa; Shiro Shibayama; Hideaki Tada; Yoshikazu Takaoka; Daikichi Fukushima; Katsuya Hisaichi; Kenji Maeda; Chiaki Minamoto; Masayuki Murota; Hisao Nakai; Toshihiko Nishiyama; Hiroaki Mitsuya
Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist.
Rena Nishizawa; Toshihiko Nishiyama; Katsuya Hisaichi; Chiaki Minamoto; Naoki Matsunaga; Yoshikazu Takaoka; Hisao Nakai; Stephen Jenkinson; Wieslaw M Kazmierski; Hideaki Tada; Kenji Sagawa; Shiro Shibayama; Daikichi Fukushima; Kenji Maeda; Hiroaki Mitsuya
Spirodiketopiperazine-based CCR5 antagonist: discovery of an antiretroviral drug candidate.
Rena Nishizawa; Toshihiko Nishiyama; Katsuya Hisaichi; Keisuke Hirai; Hiromu Habashita; Yoshikazu Takaoka; Hideaki Tada; Kenji Sagawa; Shiro Shibayama; Kenji Maeda; Hiroaki Mitsuya; Hisao Nakai; Daikichi Fukushima; Masaaki Toda
Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.

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All Publications

2011: Rena Nishizawa; Kenji Sagawa; Shiro Shibayama; Hideaki Tada; Yoshikazu Takaoka; Daikichi Fukushima; Katsuya Hisaichi; Kenji Maeda; Chiaki Minamoto; Masayuki Murota; Hisao Nakai; Toshihiko Nishiyama; Hiroaki Mitsuya
Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist.
Bioorganic & medicinal chemistry 2011;19(13):4028-42.
2011: Rena Nishizawa; Toshihiko Nishiyama; Katsuya Hisaichi; Chiaki Minamoto; Naoki Matsunaga; Yoshikazu Takaoka; Hisao Nakai; Stephen Jenkinson; Wieslaw M Kazmierski; Hideaki Tada; Kenji Sagawa; Shiro Shibayama; Daikichi Fukushima; Kenji Maeda; Hiroaki Mitsuya
Spirodiketopiperazine-based CCR5 antagonist: discovery of an antiretroviral drug candidate.
Bioorganic & medicinal chemistry letters 2011;21(4):1141-5.
2010: Rena Nishizawa; Toshihiko Nishiyama; Katsuya Hisaichi; Keisuke Hirai; Hiromu Habashita; Yoshikazu Takaoka; Hideaki Tada; Kenji Sagawa; Shiro Shibayama; Kenji Maeda; Hiroaki Mitsuya; Hisao Nakai; Daikichi Fukushima; Masaaki Toda
Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.
Bioorganic & medicinal chemistry 2010;18(14):5208-23.
2010: Rena Nishizawa; Toshihiko Nishiyama; Katsuya Hisaichi; Keisuke Hirai; Hiromu Habashita; Yoshikazu Takaoka; Hideaki Tada; Kenji Sagawa; Shiro Shibayama; Kenji Maeda; Hiroaki Mitsuya; Hisao Nakai; Daikichi Fukushima; Masaaki Toda
Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles.
Bioorganic & medicinal chemistry letters 2010;20(2):763-6.
2002: Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Hiromu Egashira; Yoshihiko Odagaki; Toru Miyazaki; Tomoyuki Hasegawa; Yasufumi Kawanaka; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Hisao Nakai; Shuichi Ohuchida; Kigen Kondo; Masaaki Toda
A practical synthesis and biological evaluation of 9-halogenated PGF analogues.
Bioorganic & medicinal chemistry 2002;10(6):1883-94.
2002: Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Hiromu Egashira; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Development of a highly selective EP2-receptor agonist. Part 2: identification of 16-hydroxy-17,17-trimethylene 9beta-chloro PGF derivatives.
Bioorganic & medicinal chemistry 2002;10(4):1107-14.
2002: Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives.
Bioorganic & medicinal chemistry 2002;10(4):1093-106.
2001: Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Hiromu Egashira; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a highly selective EP2-receptor agonist.
Bioorganic & medicinal chemistry letters 2001;11(15):2025-8.