Helene Sage

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Zhang Jingjing; Gratchev Alexei; Riabov Vladimir; Mamidi Srinivas; Schmuttermaier Christina; Krusell Liis; Kremmer Elisabeth; Workman Gail; Sage E Helene; Jalkanen Sirpa; Goerdt Sergij; Kzhyshkowska Julia
A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1.
Swinnen Melissa; Vanhoutte Davy; Van Almen Geert C; Hamdani Nazha; Schellings Mark W M; D'hooge Jan; Van der Velden Jolanda; Weaver Matthew S; Sage E Helene; Bornstein Paul; Verheyen Fons K; VandenDriessche Thierry; Chuah Marinee K; Westermann Dirk; Paulus Walter J; Van de Werf Frans; Schroen Blanche; Carmeliet Peter; Pinto Yigal M; Heymans Stephane
Absence of thrombospondin-2 causes age-related dilated cardiomyopathy.
Haddadin Ramez I; Oh Dong-Jin; Kang Min Hyung; Filippopoulos Theodoros; Gupta Meenakashi; Hart Lois; Sage E Helene; Rhee Douglas J
SPARC-null mice exhibit lower intraocular pressures.

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All Publications

2009: Zhang Jingjing; Gratchev Alexei; Riabov Vladimir; Mamidi Srinivas; Schmuttermaier Christina; Krusell Liis; Kremmer Elisabeth; Workman Gail; Sage E Helene; Jalkanen Sirpa; Goerdt Sergij; Kzhyshkowska Julia
A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1.
Molecular and cellular biology 2009;29(22):6097-105.
2009: Swinnen Melissa; Vanhoutte Davy; Van Almen Geert C; Hamdani Nazha; Schellings Mark W M; D'hooge Jan; Van der Velden Jolanda; Weaver Matthew S; Sage E Helene; Bornstein Paul; Verheyen Fons K; VandenDriessche Thierry; Chuah Marinee K; Westermann Dirk; Paulus Walter J; Van de Werf Frans; Schroen Blanche; Carmeliet Peter; Pinto Yigal M; Heymans Stephane
Absence of thrombospondin-2 causes age-related dilated cardiomyopathy.
Circulation 2009;120(16):1585-97.
2009: Haddadin Ramez I; Oh Dong-Jin; Kang Min Hyung; Filippopoulos Theodoros; Gupta Meenakashi; Hart Lois; Sage E Helene; Rhee Douglas J
SPARC-null mice exhibit lower intraocular pressures.
Investigative ophthalmology & visual science 2009;50(8):3771-7.
2009: Mandelin Jami; Lin Emme C K; Hu Dana D; Knowles Susan K; Do Kim-Anh; Wang Xuemei; Sage E Helene; Smith Jeffrey W; Arap Wadih; Pasqualini Renata
Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin.
Cancer 2009;115(8):1753-64.
2009: Schellings Mark W M; Vanhoutte Davy; Swinnen Melissa; Cleutjens Jack P; Debets Jacques; van Leeuwen Rick E W; d'Hooge Jan; Van de Werf Frans; Carmeliet Peter; Pinto Yigal M; Sage E Helene; Heymans Stephane
Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction.
The Journal of experimental medicine 2009;206(1):113-23.
2009: Nie Jing; Sage E Helene
SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling.
The Journal of biological chemistry 2009;284(2):1279-90.
2008: Nie Jing; Chang Benny; Traktuev Dmitry O; Sun Jessica; March Keith; Chan Lawrence; Sage E Helene; Pasqualini Renata; Arap Wadih; Kolonin Mikhail G
IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells.
Stem cells (Dayton, Ohio) 2008;26(10):2735-45.
2008: Weaver Matt S; Workman Gail; Sage E Helene
The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase.
The Journal of biological chemistry 2008;283(33):22826-37.
2008: Golembieski William A; Thomas Stacey L; Schultz Chad R; Yunker Christopher K; McClung Heather M; Lemke Nancy; Cazacu Simona; Barker Thomas; Sage E Helene; Brodie Chaya; Rempel Sandra A
HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion.
Glia 2008;56(10):1061-75.
2008: Clark Clancy J; Sage E Helene
A prototypic matricellular protein in the tumor microenvironment--where there's SPARC, there's fire.
Journal of cellular biochemistry 2008;104(3):721-32.
2008: Yuen Jenny; Li Yi; Shapiro Linda G; Clark John I; Arnett Ernest; Sage E Helene; Brinkley James F
Automated, computerized, feature-based phenotype analysis of slit lamp images of the mouse lens.
Experimental eye research 2008;86(4):562-75.
2008: Sullivan Millicent M; Puolakkainen Pauli A; Barker Thomas H; Funk Sarah E; Sage E Helene
Altered tissue repair in hevin-null mice: inhibition of fibroblast migration by a matricellular SPARC homolog.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2008;16(2):310-9.
2008: Kzhyshkowska Julia; Gratchev Alexei; Schmuttermaier Christina; Brundiers Heike; Krusell Liis; Mamidi Srinivas; Zhang Jingjing; Workman Gail; Sage E Helene; Anderle Christine; Sedlmayr Peter; Goerdt Sergij
Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3028-37.
2008: Gruber Helen E; Bornstein Paul; Sage E Helene; Ingram Jane A; Zinchenko Natalia; Norton H James; Hanley Edward N
Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc.
Arthritis research & therapy 2008;10(4):R96.
2008: Liu Lingyun; Chen Gang; Chao Timothy; Ratner Buddy D; Sage E Helene; Jiang Shaoyi
Reduced foreign body reaction to implanted biomaterials by surface treatment with oriented osteopontin.
Journal of biomaterials science. Polymer edition 2008;19(6):821-35.
2007: Kabosova Andrea; Azar Dimitri T; Bannikov Gregory A; Campbell Kevin P; Durbeej Madeleine; Ghohestani Reza F; Jones Jonathan C R; Kenney M Cristina; Koch Manuel; Ninomiya Yoshifumi; Patton Bruce L; Paulsson Mats; Sado Yoshikazu; Sage E Helene; Sasaki Takako; Sorokin Lydia M; Steiner-Champliaud Marie-France; Sun Tung-Tien; Sundarraj Nirmala; Timpl Rupert; Virtanen Ismo; Ljubimov Alexander V
Compositional differences between infant and adult human corneal basement membranes.
Investigative ophthalmology & visual science 2007;48(11):4989-99.
2007: Gotoh Norihito; Perdue Nikole R; Matsushima Hiroyuki; Sage E Helene; Yan Qi; Clark John I
An in vitro model of posterior capsular opacity: SPARC and TGF-beta2 minimize epithelial-to-mesenchymal transition in lens epithelium.
Investigative ophthalmology & visual science 2007;48(10):4679-87.
2007: Liu Lingyun; Ratner Buddy D; Sage E Helene; Jiang Shaoyi
Endothelial cell migration on surface-density gradients of fibronectin, VEGF, or both proteins.
Langmuir : the ACS journal of surfaces and colloids 2007;23(22):11168-73.
2007: Chen Nanyue; Ye Xiang-Cang; Chu Khoi; Navone Nora M; Sage E Helene; Yu-Lee Li-Yuan; Logothetis Christopher J; Lin Sue-Hwa
A secreted isoform of ErbB3 promotes osteonectin expression in bone and enhances the invasiveness of prostate cancer cells.
Cancer research 2007;67(14):6544-8.
2007: Au Edmund; Richter Miranda W; Vincent Adele J; Tetzlaff Wolfram; Aebersold Ruedi; Sage E Helene; Roskams A Jane
SPARC from olfactory ensheathing cells stimulates Schwann cells to promote neurite outgrowth and enhances spinal cord repair.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(27):7208-21.
2007: Rentz Tyler J; Poobalarahi Felicitta; Bornstein Paul; Sage E Helene; Bradshaw Amy D
SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts.
The Journal of biological chemistry 2007;282(30):22062-71.
2007: Tian Jing; Paquette-Straub Carrie; Sage E Helene; Funk Sarah E; Patel Vivek; Galileo Deni; McLane Mary Ann
Inhibition of melanoma cell motility by the snake venom disintegrin eristostatin.
Toxicon : official journal of the International Society on Toxinology 2007;49(7):899-908.
2007: Kelly Kimberly A; Allport Jennifer R; Yu Amy M; Sinh Sumita; Sage E Helene; Gerszten Robert E; Weissleder Ralph
SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration.
Journal of leukocyte biology 2007;81(3):748-56.
2007: Esposito Irene; Kayed Hany; Keleg Shereen; Giese Thomas; Sage E Helene; Schirmacher Peter; Friess Helmut; Kleeff Jörg
Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer.
Neoplasia (New York, N.Y.) 2007;9(1):8-17.
2007: Weaver Matt S; Toida Natalie; Sage E Helene
Expression of integrin-linked kinase in the murine lens is consistent with its role in epithelial-mesenchymal transition of lens epithelial cells in vitro.
Molecular vision 2007;13():707-18.
2006: Chavey Carine; Boucher Jérémie; Monthouël-Kartmann Marie-Noëlle; Sage E Helene; Castan-Laurell Isabelle; Valet Philippe; Tartare-Deckert Sophie; Van Obberghen Emmanuel
Regulation of secreted protein acidic and rich in cysteine during adipose conversion and adipose tissue hyperplasia.
Obesity (Silver Spring, Md.) 2006;14(11):1890-7.
2006: Biade S; Marinucci M; Schick J; Roberts D; Workman G; Sage E H; O'Dwyer P J; Livolsi V A; Johnson S W
Gene expression profiling of human ovarian tumours.
British journal of cancer 2006;95(8):1092-100.
2006: Sullivan Millicent M; Barker Thomas H; Funk Sarah E; Karchin Ari; Seo Neung S; Höök Magnus; Sanders Joan; Starcher Barry; Wight Thomas N; Puolakkainen Pauli; Sage E Helene
Matricellular hevin regulates decorin production and collagen assembly.
The Journal of biological chemistry 2006;281(37):27621-32.
2006: Järveläinen Hannu; Puolakkainen Pauli; Pakkanen Sari; Brown Eric L; Höök Magnus; Iozzo Renato V; Sage E Helene; Wight Thomas N
A role for decorin in cutaneous wound healing and angiogenesis.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2006;14(4):443-52.
2006: Emerson Ryan O; Sage E Helene; Ghosh Joy G; Clark John I
Chaperone-like activity revealed in the matricellular protein SPARC.
Journal of cellular biochemistry 2006;98(4):701-5.
2006: Kzhyshkowska Julia; Workman Gail; Cardó-Vila Marina; Arap Wadih; Pasqualini Renata; Gratchev Alexei; Krusell Liis; Goerdt Sergij; Sage E Helene
Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):5825-32.
2006: Hecht Jacqueline T; Sage E Helene
Retention of the matricellular protein SPARC in the endoplasmic reticulum of chondrocytes from patients with pseudoachondroplasia.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006;54(3):269-74.
2006: Nozaki Miho; Sakurai Eiji; Raisler Brian J; Baffi Judit Z; Witta Jassir; Ogura Yuichiro; Brekken Rolf A; Sage E Helene; Ambati Balamurali K; Ambati Jayakrishna
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A.
The Journal of clinical investigation 2006;116(2):422-9.
2006: Weaver Matt S; Sage E Helene; Yan Qi
Absence of SPARC in lens epithelial cells results in altered adhesion and extracellular matrix production in vitro.
Journal of cellular biochemistry 2006;97(2):423-32.
2006: Wang Hua; Workman Gail; Chen Shengfu; Barker Thomas H; Ratner Buddy D; Sage E Helene; Jiang Shaoyi
Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM-40) binds to fibrinogen fragments D and E, but not to native fibrinogen.
Matrix biology : journal of the International Society for Matrix Biology 2006;25(1):20-6.
2005: Yan Qi; Perdue Nikole; Blake David; Sage E Helene
Absence of SPARC in murine lens epithelium leads to increased deposition of laminin-1 in lens capsule.
Investigative ophthalmology & visual science 2005;46(12):4652-60.
2005: Yan Qi; Perdue Nikole; Sage E Helene
Differential responses of human lens epithelial cells to intraocular lenses in vitro: hydrophobic acrylic versus PMMA or silicone discs.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2005;243(12):1253-62.
2005: Wang Hua; Fertala Andrzej; Ratner Buddy D; Sage E Helene; Jiang Shaoyi
Identifying the SPARC binding sites on collagen I and procollagen I by atomic force microscopy.
Analytical chemistry 2005;77(21):6765-71.
2005: Barker Thomas H; Baneyx Gretchen; Cardó-Vila Marina; Workman Gail A; Weaver Matt; Menon Priya M; Dedhar Shoukat; Rempel Sandra A; Arap Wadih; Pasqualini Renata; Vogel Viola; Sage E Helene
SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity.
The Journal of biological chemistry 2005;280(43):36483-93.
2005: Gruber Helen E; Sage E Helene; Norton H James; Funk Sarah; Ingram Jane; Hanley Edward N
Targeted deletion of the SPARC gene accelerates disc degeneration in the aging mouse.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(9):1131-8.
2005: Reed May J; Bradshaw A D; Shaw M; Sadoun E; Han N; Ferara N; Funk S; Puolakkainen P; Sage E H
Enhanced angiogenesis characteristic of SPARC-null mice disappears with age.
Journal of cellular physiology 2005;204(3):800-7.
2005: Puolakkainen Pauli A; Bradshaw Amy D; Brekken Rolf A; Reed May J; Kyriakides Themis; Funk Sarah E; Gooden Michel D; Vernon Robert B; Wight Thomas N; Bornstein Paul; Sage E Helene
SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(5):571-81.
2005: Yan Qi; Weaver Matt; Perdue Nikole; Sage E Helene
Matricellular protein SPARC is translocated to the nuclei of immortalized murine lens epithelial cells.
Journal of cellular physiology 2005;203(1):286-94.
2005: Barker Thomas H; Framson Paul; Puolakkainen Pauli A; Reed May; Funk Sarah E; Sage E Helene
Matricellular homologs in the foreign body response: hevin suppresses inflammation, but hevin and SPARC together diminish angiogenesis.
The American journal of pathology 2005;166(3):923-33.
2004: Aycock Ronnie L; Bradshaw Amy C; Sage E Helene; Starcher Barry
Development of UV-induced squamous cell carcinomas is suppressed in the absence of SPARC.
The Journal of investigative dermatology 2004;123(3):592-9.
2004: Framson Paul E; Sage E Helene
SPARC and tumor growth: where the seed meets the soil?
Journal of cellular biochemistry 2004;92(4):679-90.
2004: Brekken Rolf A; Sullivan Millicent M; Workman Gail; Bradshaw Amy D; Carbon Juliet; Siadak Anthony; Murri Carrie; Framson Paul E; Sage E Helene
Expression and characterization of murine hevin (SC1), a member of the SPARC family of matricellular proteins.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(6):735-48.
2004: Sweetwyne Mariya T; Brekken Rolf A; Workman Gail; Bradshaw Amy D; Carbon Juliet; Siadak Anthony W; Murri Carrie; Sage E Helene
Functional analysis of the matricellular protein SPARC with novel monoclonal antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(6):723-33.
2004: Sullivan Millicent M; Sage E Helene
Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family.
The international journal of biochemistry & cell biology 2004;36(6):991-6.
2004: Puolakkainen Pauli A; Brekken Rolf A; Muneer Sabeeha; Sage E Helene
Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis.
Molecular cancer research : MCR 2004;2(4):215-24.
2004: Hirano Shuichi; Yonezawa Tomoko; Hasegawa Haruko; Hattori Shunji; Greenhill Nicholas S; Davis Paul F; Sage E Helene; Ninomiya Yoshifumi
Astrocytes express type VIII collagen during the repair process of brain cold injury.
Biochemical and biophysical research communications 2004;317(2):437-43.
2004: Francki Aleksandar; McClure Timothy D; Brekken Rolf A; Motamed Kouros; Murri Carrie; Wang Tongwen; Sage E Helene
SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells.
Journal of cellular biochemistry 2004;91(5):915-25.
2004: Gongidi Vik; Ring Colleen; Moody Matt; Brekken Rolf; Sage E Helene; Rakic Pasko; Anton E S
SPARC-like 1 regulates the terminal phase of radial glia-guided migration in the cerebral cortex.
Neuron 2004;41(1):57-69.
2004: Järveläinen Hannu; Vernon Robert B; Gooden Michel D; Francki Aleksandar; Lara Stephanie; Johnson Pamela Y; Kinsella Michael G; Sage E Helene; Wight Thomas N
Overexpression of decorin by rat arterial smooth muscle cells enhances contraction of type I collagen in vitro.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(1):67-72.
2003: Rhee Douglas J; Fariss Robert N; Brekken Rolf; Sage E Helene; Russell Paul
The matricellular protein SPARC is expressed in human trabecular meshwork.
Experimental eye research 2003;77(5):601-7.
2003: Motamed Kouros; Blake David J; Angello John C; Allen Benjamin L; Rapraeger Alan C; Hauschka Stephen D; Sage E Helene
Fibroblast growth factor receptor-1 mediates the inhibition of endothelial cell proliferation and the promotion of skeletal myoblast differentiation by SPARC: a role for protein kinase A.
Journal of cellular biochemistry 2003;90(2):408-23.
2003: De Sarmishtha; Chen Juhua; Narizhneva Natalya V; Heston Warren; Brainard Jennifer; Sage E Helene; Byzova Tatiana V
Molecular pathway for cancer metastasis to bone.
The Journal of biological chemistry 2003;278(40):39044-50.
2003: Koukourakis Michael I; Giatromanolaki Alexandra; Brekken Rolf A; Sivridis Efthimios; Gatter Kevin C; Harris Adrian L; Sage E Helene
Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients.
Cancer research 2003;63(17):5376-80.
2003: Sage E Helene; Reed May; Funk Sarah E; Truong Thao; Steadele Melissa; Puolakkainen Pauli; Maurice Donald H; Bassuk James A
Cleavage of the matricellular protein SPARC by matrix metalloproteinase 3 produces polypeptides that influence angiogenesis.
The Journal of biological chemistry 2003;278(39):37849-57.
2003: Delany Anne M; Kalajzic Ivo; Bradshaw Amy D; Sage E Helene; Canalis Ernesto
Osteonectin-null mutation compromises osteoblast formation, maturation, and survival.
Endocrinology 2003;144(6):2588-96.
2003: Bradshaw A D; Graves D C; Motamed K; Sage E H
SPARC-null mice exhibit increased adiposity without significant differences in overall body weight.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6045-50.
2003: Taneda Sekiko; Pippin Jeffrey W; Sage E Helene; Hudkins Kelly L; Takeuchi Yasuo; Couser William G; Alpers Charles E
Amelioration of diabetic nephropathy in SPARC-null mice.
Journal of the American Society of Nephrology : JASN 2003;14(4):968-80.
2003: Yan Qi; Blake David; Clark John I; Sage E Helene
Expression of the matricellular protein SPARC in murine lens: SPARC is necessary for the structural integrity of the capsular basement membrane.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003;51(4):503-11.
2003: Francki Aleksandar; Motamed Kouros; McClure Timothy D; Kaya Marcus; Murri Carrie; Blake David J; Carbon Juliet G; Sage E Helene
SPARC regulates cell cycle progression in mesangial cells via its inhibition of IGF-dependent signaling.
Journal of cellular biochemistry 2003;88(4):802-11.
2003: Sage E Helene
Purification of SPARC/osteonectin.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2003;Chapter 10():Unit 10.11.
2003: Brekken Rolf A; Puolakkainen Pauli; Graves David C; Workman Gail; Lubkin Sharon R; Sage E Helene
Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM.
The Journal of clinical investigation 2003;111(4):487-95.
2003: Puolakkainen Pauli; Bradshaw Amy D; Kyriakides Themistoklis R; Reed May; Brekken Rolf; Wight Thomas; Bornstein Paul; Ratner Buddy; Sage E Helene
Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials.
The American journal of pathology 2003;162(2):627-35.
2003: Reed May J; Koike Teruhiko; Sadoun Eman; Sage E Helene; Puolakkainen Pauli
Inhibition of TIMP1 enhances angiogenesis in vivo and cell migration in vitro.
Microvascular research 2003;65(1):9-17.
2002: Alpers Charles E; Hudkins Kelly L; Segerer Stephan; Sage E Helene; Pichler Raimund; Couser William G; Johnson Richard J; Bassuk James A
Localization of SPARC in developing, mature, and chronically injured human allograft kidneys.
Kidney international 2002;62(6):2073-86.
2002: Bornstein Paul; Sage E Helene
Matricellular proteins: extracellular modulators of cell function.
Current opinion in cell biology 2002;14(5):608-16.
2002: Yan Qi; Clark John I; Wight Thomas N; Sage E Helene
Alterations in the lens capsule contribute to cataractogenesis in SPARC-null mice.
Journal of cell science 2002;115(Pt 13):2747-56.
2002: Avakian Arpenik; Kalina Robert E; Sage E Helene; Rambhia Avni H; Elliott Katherine E; Chuang Elaine L; Clark John I; Hwang Jenq-Neng; Parsons-Wingerter Patricia
Fractal analysis of region-based vascular change in the normal and non-proliferative diabetic retina.
Current eye research 2002;24(4):274-80.
2002: Netherton Stuart J; Jimmo Sandra L; Palmer Daniel; Tilley Douglas G; Dunkerley Heather A; Raymond Daniel R; Russell James C; Absher P Marlene; Sage E Helene; Vernon Robert B; Maurice Donald H
Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease.
Diabetes 2002;51(4):1194-200.
2002: Bradshaw Amy D; Reed May J; Sage E Helene
SPARC-null mice exhibit accelerated cutaneous wound closure.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002;50(1):1-10.
2002: Motamed Kouros; Funk Sarah E; Koyama Hidenori; Ross Russell; Raines Elaine W; Sage E Helene
Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors.
Journal of cellular biochemistry 2002;84(4):759-71.
2001: Bradshaw A D; Reed M J; Carbon J G; Pinney E; Brekken R A; Sage E H
Increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges in SPARC-null mice.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2001;9(6):522-30.
2001: Bradshaw A D; Sage E H
SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury.
The Journal of clinical investigation 2001;107(9):1049-54.
2001: Sage E H
Regulation of interactions between cells and extracellular matrix: a command performance on several stages.
The Journal of clinical investigation 2001;107(7):781-3.
2001: Francki A; Sage E H
SPARC and the kidney glomerulus: matricellular proteins exhibit diverse functions under normal and pathological conditions.
Trends in cardiovascular medicine 2001;11(1):32-7.
2000: Norose K; Lo W K; Clark J I; Sage E H; Howe C C
Lenses of SPARC-null mice exhibit an abnormal cell surface-basement membrane interface.
Experimental eye research 2000;71(3):295-307.
2000: Yan Q; Clark J I; Sage E H
Expression and characterization of SPARC in human lens and in the aqueous and vitreous humors.
Experimental eye research 2000;71(1):81-90.
2000: Bradshaw A D; Bassuk J A; Francki A; Sage E H
Expression and purification of recombinant human SPARC produced by baculovirus.
Molecular cell biology research communications : MCBRC 2000;3(6):345-51.
2000: Parsons-Wingerter P; Elliott K E; Farr A G; Radhakrishnan K; Clark J I; Sage E H
Generational analysis reveals that TGF-beta1 inhibits the rate of angiogenesis in vivo by selective decrease in the number of new vessels.
Microvascular research 2000;59(2):221-32.
2000: Bassuk J A; Pichler R; Rothmier J D; Pippen J; Gordon K; Meek R L; Bradshaw A D; Lombardi D; Strandjord T P; Reed M; Sage E H; Couser W G; Johnson R
Induction of TGF-beta1 by the matricellular protein SPARC in a rat model of glomerulonephritis.
Kidney international 2000;57(1):117-28.
1999: Yan Q; Sage E H
SPARC, a matricellular glycoprotein with important biological functions.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999;47(12):1495-506.
1999: Francki A; Bradshaw A D; Bassuk J A; Howe C C; Couser W G; Sage E H
SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells.
The Journal of biological chemistry 1999;274(45):32145-52.
1999: Strandjord T P; Madtes D K; Weiss D J; Sage E H
Collagen accumulation is decreased in SPARC-null mice with bleomycin-induced pulmonary fibrosis.
The American journal of physiology 1999;277(3 Pt 1):L628-35.
1999: Gooden M D; Vernon R B; Bassuk J A; Sage E H
Cell cycle-dependent nuclear location of the matricellular protein SPARC: association with the nuclear matrix.
Journal of cellular biochemistry 1999;74(2):152-67.
1999: Bradshaw A D; Francki A; Motamed K; Howe C; Sage E H
Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation.
Molecular biology of the cell 1999;10(5):1569-79.
1999: Bassuk J A; Birkebak T; Rothmier J D; Clark J M; Bradshaw A; Muchowski P J; Howe C C; Clark J I; Sage E H
Disruption of the Sparc locus in mice alters the differentiation of lenticular epithelial cells and leads to cataract formation.
Experimental eye research 1999;68(3):321-31.
1999: Vernon R B; Sage E H
A novel, quantitative model for study of endothelial cell migration and sprout formation within three-dimensional collagen matrices.
Microvascular research 1999;57(2):118-33.
1999: Redlitz A; Daum G; Sage E H
Angiostatin diminishes activation of the mitogen-activated protein kinases ERK-1 and ERK-2 in human dermal microvascular endothelial cells.
Journal of vascular research 1999;36(1):28-34.
1998: Norose K; Clark J I; Syed N A; Basu A; Heber-Katz E; Sage E H; Howe C C
SPARC deficiency leads to early-onset cataractogenesis.
Investigative ophthalmology & visual science 1998;39(13):2674-80.
1998: Kupprion C; Motamed K; Sage E H
SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells.
The Journal of biological chemistry 1998;273(45):29635-40.
1998: Motamed K; Sage E H
SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway.
Journal of cellular biochemistry 1998;70(4):543-52.
1998: Yan Q; Sage E H
Transforming growth factor-beta1 induces apoptotic cell death in cultured retinal endothelial cells but not pericytes: association with decreased expression of p21waf1/cip1.
Journal of cellular biochemistry 1998;70(1):70-83.
1998: Arthur W T; Vernon R B; Sage E H; Reed M J
Growth factors reverse the impaired sprouting of microvessels from aged mice.
Microvascular research 1998;55(3):260-70.
1998: Parsons-Wingerter P; Lwai B; Yang M C; Elliott K E; Milaninia A; Redlitz A; Clark J I; Sage E H
A novel assay of angiogenesis in the quail chorioallantoic membrane: stimulation by bFGF and inhibition by angiostatin according to fractal dimension and grid intersection.
Microvascular research 1998;55(3):201-14.
1998: Yan Q; Sage E H; Hendrickson A E
SPARC is expressed by ganglion cells and astrocytes in bovine retina.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(1):3-10.
1998: Reed M J; Corsa A; Pendergrass W; Penn P; Sage E H; Abrass I B
Neovascularization in aged mice: delayed angiogenesis is coincident with decreased levels of transforming growth factor beta1 and type I collagen.
The American journal of pathology 1998;152(1):113-23.
1997: Soderling J A; Reed M J; Corsa A; Sage E H
Cloning and expression of murine SC1, a gene product homologous to SPARC.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1997;45(6):823-35.
1997: Schneider E L; Thomas J G; Bassuk J A; Sage E H; Baneyx F
Manipulating the aggregation and oxidation of human SPARC in the cytoplasm of Escherichia coli.
Nature biotechnology 1997;15(6):581-5.
1997: Motamed K; Sage E H
Regulation of vascular morphogenesis by the matricellular protein SPARC.
Kidney international 1997;51(5):1383-7.
1996: Pichler R H; Hugo C; Shankland S J; Reed M J; Bassuk J A; Andoh T F; Lombardi D M; Schwartz S M; Bennett W M; Alpers C E; Sage E H; Johnson R J; Couser W G
SPARC is expressed in renal interstitial fibrosis and in renal vascular injury.
Kidney international 1996;50(6):1978-89.
1996: Gariano R F; Sage E H; Kaplan H J; Hendrickson A E
Development of astrocytes and their relation to blood vessels in fetal monkey retina.
Investigative ophthalmology & visual science 1996;37(12):2367-75.
1996: Iruela-Arispe M L; Vernon R B; Wu H; Jaenisch R; Sage E H
Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function.
Developmental dynamics : an official publication of the American Association of Anatomists 1996;207(2):171-83.
1996: Yan Q; Vernon R B; Hendrickson A E; Sage E H
Primary culture and characterization of microvascular endothelial cells from Macaca monkey retina.
Investigative ophthalmology & visual science 1996;37(11):2185-94.
1996: Bassuk J A; Braun L P; Motamed K; Baneyx F; Sage E H
Renaturation of SPARC expressed in Escherichia coli requires isomerization of disulfide bonds for recovery of biological activity.
The international journal of biochemistry & cell biology 1996;28(9):1031-43.
1996: Reed M J; Penn P E; Li Y; Birnbaum R; Vernon R B; Johnson T S; Pendergrass W R; Sage E H; Abrass I B; Wolf N S
Enhanced cell proliferation and biosynthesis mediate improved wound repair in refed, caloric-restricted mice.
Mechanisms of ageing and development 1996;89(1):21-43.
1996: Luther T; Flössel C; Mackman N; Bierhaus A; Kasper M; Albrecht S; Sage E H; Iruela-Arispe L; Grossmann H; Ströhlein A; Zhang Y; Nawroth P P; Carmeliet P; Loskutoff D J; Müller M
Tissue factor expression during human and mouse development.
The American journal of pathology 1996;149(1):101-13.
1996: Pichler R H; Bassuk J A; Hugo C; Reed M J; Eng E; Gordon K L; Pippin J; Alpers C E; Couser W G; Sage E H; Johnson R J
SPARC is expressed by mesangial cells in experimental mesangial proliferative nephritis and inhibits platelet-derived-growth-factor-medicated mesangial cell proliferation in vitro.
The American journal of pathology 1996;148(4):1153-67.
1996: Vernon R B; Sage E H
Contraction of fibrillar type I collagen by endothelial cells: a study in vitro.
Journal of cellular biochemistry 1996;60(2):185-97.
1996: Bassuk J A; Baneyx F; Vernon R B; Funk S E; Sage E H
Expression of biologically active human SPARC in Escherichia coli.
Archives of biochemistry and biophysics 1996;325(1):8-19.
1996: Gariano R F; Iruela-Arispe M L; Sage E H; Hendrickson A E
Immunohistochemical characterization of developing and mature primate retinal blood vessels.
Investigative ophthalmology & visual science 1996;37(1):93-103.
1996: Reed M J; Sage E H
SPARC and the extracellular matrix: implications for cancer and wound repair.
Current topics in microbiology and immunology 1996;213 ( Pt 1)():81-94.
1995: Vernon R B; Sage E H
Between molecules and morphology. Extracellular matrix and creation of vascular form.
The American journal of pathology 1995;147(4):873-83.
1995: Reed M J; Iruela-Arispe L; O'Brien E R; Truong T; LaBell T; Bornstein P; Sage E H
Expression of thrombospondins by endothelial cells. Injury is correlated with TSP-1.
The American journal of pathology 1995;147(4):1068-80.
1995: Strandjord T P; Sage E H; Clark J G
SPARC participates in the branching morphogenesis of developing fetal rat lung.
American journal of respiratory cell and molecular biology 1995;13(3):279-87.
1995: Porter P L; Sage E H; Lane T F; Funk S E; Gown A M
Distribution of SPARC in normal and neoplastic human tissue.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(8):791-800.
1995: Iruela-Arispe M L; Lane T F; Redmond D; Reilly M; Bolender R P; Kavanagh T J; Sage E H
Expression of SPARC during development of the chicken chorioallantoic membrane: evidence for regulated proteolysis in vivo.
Molecular biology of the cell 1995;6(3):327-43.
1995: Murphy-Ullrich J E; Lane T F; Pallero M A; Sage E H
SPARC mediates focal adhesion disassembly in endothelial cells through a follistatin-like region and the Ca(2+)-binding EF-hand.
Journal of cellular biochemistry 1995;57(2):341-50.
1995: Vernon R B; Lara S L; Drake C J; Iruela-Arispe M L; Angello J C; Little C D; Wight T N; Sage E H
Organized type I collagen influences endothelial patterns during "spontaneous angiogenesis in vitro": planar cultures as models of vascular development.
In vitro cellular & developmental biology. Animal 1995;31(2):120-31.
1995: Sage E H; Bassuk J A; Yost J C; Folkman M J; Lane T F
Inhibition of endothelial cell proliferation by SPARC is mediated through a Ca(2+)-binding EF-hand sequence.
Journal of cellular biochemistry 1995;57(1):127-40.
1994: Yost J C; Bell A; Seale R; Sage E H
Purification of biologically active SPARC expressed in Saccharomyces cerevisiae.
Archives of biochemistry and biophysics 1994;314(1):50-63.
1994: Liska D J; Reed M J; Sage E H; Bornstein P
Cell-specific expression of alpha 1(I) collagen-hGH minigenes in transgenic mice.
The Journal of cell biology 1994;125(3):695-704.
1994: Lane T F; Iruela-Arispe M L; Johnson R S; Sage E H
SPARC is a source of copper-binding peptides that stimulate angiogenesis.
The Journal of cell biology 1994;125(4):929-43.
1994: Battegay E J; Rupp J; Iruela-Arispe L; Sage E H; Pech M
PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors.
The Journal of cell biology 1994;125(4):917-28.
1994: Lane T F; Sage E H
The biology of SPARC, a protein that modulates cell-matrix interactions.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(2):163-73.
1994: Reed M J; Vernon R B; Abrass I B; Sage E H
TGF-beta 1 induces the expression of type I collagen and SPARC, and enhances contraction of collagen gels, by fibroblasts from young and aged donors.
Journal of cellular physiology 1994;158(1):169-79.
1994: Bornstein P; Sage E H
Thrombospondins.
Methods in enzymology 1994;245():62-85.
1993: Yost J C; Sage E H
Specific interaction of SPARC with endothelial cells is mediated through a carboxyl-terminal sequence containing a calcium-binding EF hand.
The Journal of biological chemistry 1993;268(34):25790-6.
1993: Bassuk J A; Iruela-Arispe M L; Lane T F; Benson J M; Berg R A; Sage E H
Molecular analysis of chicken embryo SPARC (osteonectin).
European journal of biochemistry / FEBS 1993;218(1):117-27.
1993: Reed M J; Puolakkainen P; Lane T F; Dickerson D; Bornstein P; Sage E H
Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1993;41(10):1467-77.
1993: Iruela-Arispe M L; Sage E H
Endothelial cells exhibiting angiogenesis in vitro proliferate in response to TGF-beta 1.
Journal of cellular biochemistry 1993;52(4):414-30.
1993: Tremble P M; Lane T F; Sage E H; Werb Z
SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway.
The Journal of cell biology 1993;121(6):1433-44.
1993: Iruela-Arispe M L; Liska D J; Sage E H; Bornstein P
Differential expression of thrombospondin 1, 2, and 3 during murine development.
Developmental dynamics : an official publication of the American Association of Anatomists 1993;197(1):40-56.
1993: Funk S E; Sage E H
Differential effects of SPARC and cationic SPARC peptides on DNA synthesis by endothelial cells and fibroblasts.
Journal of cellular physiology 1993;154(1):53-63.
1992: Everitt E A; Sage E H
Overexpression of SPARC in stably transfected F9 cells mediates attachment and spreading in Ca(2+)-deficient medium.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(12):1368-79.
1992: Järveläinen H T; Iruela-Arispe M L; Kinsella M G; Sandell L J; Sage E H; Wight T N
Expression of decorin by sprouting bovine aortic endothelial cells exhibiting angiogenesis in vitro.
Experimental cell research 1992;203(2):395-401.
1992: Floege J; Alpers C E; Sage E H; Pritzl P; Gordon K; Johnson R J; Couser W G
Markers of complement-dependent and complement-independent glomerular visceral epithelial cell injury in vivo. Expression of antiadhesive proteins and cytoskeletal changes.
Laboratory investigation; a journal of technical methods and pathology 1992;67(4):486-97.
1992: Lane T F; Iruela-Arispe M L; Sage E H
Regulation of gene expression by SPARC during angiogenesis in vitro. Changes in fibronectin, thrombospondin-1, and plasminogen activator inhibitor-1.
The Journal of biological chemistry 1992;267(23):16736-45.
1992: Hasselaar P; Sage E H
SPARC antagonizes the effect of basic fibroblast growth factor on the migration of bovine aortic endothelial cells.
Journal of cellular biochemistry 1992;49(3):272-83.
1992: Sage E H
Secretion of SPARC by endothelial cells transformed by polyoma middle T oncogene inhibits the growth of normal endothelial cells in vitro.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(7):579-92.
1992: Vernon R B; Angello J C; Iruela-Arispe M L; Lane T F; Sage E H
Reorganization of basement membrane matrices by cellular traction promotes the formation of cellular networks in vitro.
Laboratory investigation; a journal of technical methods and pathology 1992;66(5):536-47.
1992: Everitt E A; Sage E H
Expression of SPARC is correlated with altered morphologies in transfected F9 embryonal carcinoma cells.
Experimental cell research 1992;199(1):134-46.
1992: Raines E W; Lane T F; Iruela-Arispe M L; Ross R; Sage E H
The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1281-5.
1992: Sage E H
Modulation of endothelial cell shape by SPARC does not involve chelation of extracellular Ca2+ and Mg2+.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(1):56-62.
1991: Fouser L; Sage E H; Clark J; Bornstein P
Feedback regulation of collagen gene expression: a Trojan horse approach.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10158-62.
1991: Fouser L; Iruela-Arispe L; Bornstein P; Sage E H
Transcriptional activity of the alpha 1(I)-collagen promoter is correlated with the formation of capillary-like structures by endothelial cells in vitro.
The Journal of biological chemistry 1991;266(27):18345-51.
1991: Sage E H; Bornstein P
Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin.
The Journal of biological chemistry 1991;266(23):14831-4.
1991: Hasselaar P; Loskutoff D J; Sawdey M; Sage E H
SPARC induces the expression of type 1 plasminogen activator inhibitor in cultured bovine aortic endothelial cells.
The Journal of biological chemistry 1991;266(20):13178-84.
1991: Iruela-Arispe M L; Diglio C A; Sage E H
Modulation of extracellular matrix proteins by endothelial cells undergoing angiogenesis in vitro.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(4):805-15.
1991: Funk S E; Sage E H
The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2648-52.
1990: Lane T F; Sage E H
Functional mapping of SPARC: peptides from two distinct Ca+(+)-binding sites modulate cell shape.
The Journal of cell biology 1990;111(6 Pt 2):3065-76.
1988: Kapoor R; Sakai L Y; Funk S; Roux E; Bornstein P; Sage E H
Type VIII collagen has a restricted distribution in specialized extracellular matrices.
The Journal of cell biology 1988;107(2):721-30.

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