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Dinah Sah

Research Profile

Chemicals & Drugs

Living Beings

Phenomena

RNA Interference

Anatomy

Physiology

Gene Silencing

Disorders

Pain

Co-author Network

Publications

TOP 3
Rudy Bonavia; Webster K Cavenee; Sheue-Yann Cheng; P Hadwiger; M M Inda; Motoo Nagane; Dinah W Y Sah; P Tan; S Vandenberg; Frank B Furnari
EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway.
Yuya Hayashi; Taishi Higashi; Hirofumi Jono; Yoshimasa Mori; Keiichi Motoyama; Dinah W Y Sah; Yukio Ando; Hidetoshi Arima
Systemic delivery of transthyretin siRNA mediated by lactosylated dendrimer/α-cyclodextrin conjugates into hepatocyte for familial amyloidotic polyneuropathy therapy.
David K Stiles; Lubomir Tchangov; Zhiming Zhang; Gregory R Stewart; Yi Ai; Mark T Butt; Klaus Charisse; Don M Gash; Pei Ge; Richard Grondin; Andrei P Guzaev; Douglas Gwost; Peter Hardy; William F Kaemmerer; Verbena Kosovrasti; Martin Maier; Muthiah Manoharan; Michael Meys; Lubomir Nechev; Brian Nelson; Peter T Nelson; Dinah W Y Sah
Widespread suppression of huntingtin with convection-enhanced delivery of siRNA.

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All Publications

2012: Rudy Bonavia; Webster K Cavenee; Sheue-Yann Cheng; P Hadwiger; M M Inda; Motoo Nagane; Dinah W Y Sah; P Tan; S Vandenberg; Frank B Furnari
EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway.
Oncogene 2012;31(36):4054-66.
2012: Yuya Hayashi; Taishi Higashi; Hirofumi Jono; Yoshimasa Mori; Keiichi Motoyama; Dinah W Y Sah; Yukio Ando; Hidetoshi Arima
Systemic delivery of transthyretin siRNA mediated by lactosylated dendrimer/α-cyclodextrin conjugates into hepatocyte for familial amyloidotic polyneuropathy therapy.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2012;19 Suppl 1():47-9.
2012: David K Stiles; Lubomir Tchangov; Zhiming Zhang; Gregory R Stewart; Yi Ai; Mark T Butt; Klaus Charisse; Don M Gash; Pei Ge; Richard Grondin; Andrei P Guzaev; Douglas Gwost; Peter Hardy; William F Kaemmerer; Verbena Kosovrasti; Martin Maier; Muthiah Manoharan; Michael Meys; Lubomir Nechev; Brian Nelson; Peter T Nelson; Dinah W Y Sah
Widespread suppression of huntingtin with convection-enhanced delivery of siRNA.
Experimental neurology 2012;233(1):463-71.
2011: Dinah W Y Sah; Neil Aronin
Oligonucleotide therapeutic approaches for Huntington disease.
The Journal of clinical investigation 2011;121(2):500-7.
2010: Maria-del-Mar Inda; Rudy Bonavia; Akitake Mukasa; Yoshitaka Narita; Dinah W Y Sah; Scott Vandenberg; Cameron Brennan; Terrance G Johns; Robert M Bachoo; Philipp Hadwiger; Pamela Tan; Ronald A DePinho; Webster K Cavenee; Frank B Furnari
Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma.
Genes & development 2010;24(16):1731-45.
2010: Akin Akinc; William Querbes; Soma De; June Qin; Maria Frank-Kamenetsky; K Narayanannair Jayaprakash; Muthusamy Jayaraman; Kallanthottathil G Rajeev; William L Cantley; J Robert Dorkin; James S Butler; Liuliang Qin; Timothy Racie; Andrew Sprague; Eugenio Fava; Anja Zeigerer; Michael J Hope; Marino Zerial; Dinah W Y Sah; Kevin Fitzgerald; Mark A Tracy; Muthiah Manoharan; Victor Koteliansky; Antonin de Fougerolles; Martin A Maier
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(7):1357-64.
2010: Qingmin Chen; David Butler; William Querbes; Rajendra K Pandey; Pei Ge; Martin A Maier; Ligang Zhang; Kallanthottathil G Rajeev; Lubomir Nechev; Victor Kotelianski; Muthiah Manoharan; Dinah W Y Sah
Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery.
Journal of controlled release : official journal of the Controlled Release Society 2010;144(2):227-32.
2010: Kevin T Love; Kerry P Mahon; Christopher G Levins; Kathryn A Whitehead; William Querbes; J Robert Dorkin; June Qin; William Cantley; Liu-liang Qin; Timothy Racie; Maria Frank-Kamenetsky; Ka Ning Yip; Rene Alvarez; Dinah W Y Sah; Antonin de Fougerolles; Kevin Fitzgerald; Victor E Koteliansky; Akin Akinc; Robert Langer; Daniel G Anderson
Lipid-like materials for low-dose, in vivo gene silencing.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):1864-9.
2009: Richard Tritz; Michelle J Hickey; Amy H Lin; Philipp Hadwiger; Dinah W Y Sah; Edward A Neuwelt; Barbara M Mueller; Carol A Kruse
FAPP2 gene downregulation increases tumor cell sensitivity to Fas-induced apoptosis.
Biochemical and biophysical research communications 2009;383(2):167-71.
2009: William Querbes; Pei Ge; Wenjun Zhang; Yupeng Fan; Jason Costigan; Klaus Charisse; Martin Maier; Lubomir Nechev; Muthiah Manoharan; Victor Kotelianski; Dinah W Y Sah
Direct CNS delivery of siRNA mediates robust silencing in oligodendrocytes.
Oligonucleotides 2009;19(1):23-29.
2008: Jeffrey W Hewett; Flávia Nery; Brian Niland; Pei Ge; Pamela Tan; Philipp Hadwiger; Bakhos A Tannous; Dinah W Y Sah; Xandra O Breakefield
siRNA knock-down of mutant torsinA restores processing through secretory pathway in DYT1 dystonia cells.
Human molecular genetics 2008;17(10):1436-45.
2008: Ruizhong Wang; Tamara King; Michael H Ossipov; Anthony J Rossomando; Todd W Vanderah; Pamela Harvey; Peter Cariani; Eric Frank; Dinah W Y Sah; Frank Porreca
Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury.
Nature neuroscience 2008;11(4):488-96.
2006: David Bumcrot; Muthiah Manoharan; Victor E Koteliansky; Dinah W Y Sah
RNAi therapeutics: a potential new class of pharmaceutical drugs.
Nature chemical biology 2006;2(12):711-9.
2006: Kristin Larsen; Susanna C Benn; Ilknur Ay; Ru-Ju Chian; Samuel A Celia; Mary P Remington; Michelle Bejarano; Meiqin Liu; Joshua Ross; Paul Carmillo; Dinah W Y Sah; Kester A Phillips; David Sulzer; R Blake Pepinsky; Paul S Fishman; Robert H Brown; Jonathan W Francis
A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice.
Brain research 2006;1120(1):1-12.
2006: Dinah W Y Sah
Therapeutic potential of RNA interference for neurological disorders.
Life sciences 2006;79(19):1773-80.
2006: Laura Silvian; Ping Jin; Paul Carmillo; P Ann Boriack-Sjodin; Carolyn Pelletier; Mia Rushe; BangJian Gong; Dinah W Y Sah; Blake Pepinsky; Anthony Rossomando
Artemin crystal structure reveals insights into heparan sulfate binding.
Biochemistry 2006;45(22):6801-12.
2006: Chunhua Yang; David Hutto; Dinah W Y Sah
Distribution of GDNF family receptor alpha3 and RET in rat and human non-neural tissues.
Journal of molecular histology 2006;37(1-2):69-77.
2005: Sha Mi; Robert H Miller; Xinhua Lee; Martin L Scott; Svetlane Shulag-Morskaya; Zhaohui Shao; Jufang Chang; Greg Thill; Melissa Levesque; Mingdi Zhang; Cathy Hession; Dinah W Y Sah; Bruce Trapp; Zhigang He; Vincent Jung; John McCoy; R Blake Pepinsky
LINGO-1 negatively regulates myelination by oligodendrocytes.
Nature neuroscience 2005;8(6):745-51.
2005: Paul Carmillo; Lone Dagø; Eric S Day; Dane Worley; Anthony Rossomando; Lee Walus; Olivia Orozco; Carolyn Buckley; Stephan Miller; Albert Tse; Richard L Cate; Carl Rosenblad; Dinah W Y Sah; Mette Grønborg; Adrian Whitty
Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin.
Biochemistry 2005;44(7):2545-54.
2005: Zhaohui Shao; Jeffrey L Browning; Xinhua Lee; Martin L Scott; Svetlana Shulga-Morskaya; Normand E Allaire; Greg Thill; Melissa Levesque; Dinah W Y Sah; John McCoy; Beth Murray; Vincent Jung; R Blake Pepinsky; Sha Mi
TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration.
Neuron 2005;45(3):353-9.
2005: Dinah W Y Sah; Michael H Ossipov; Anthony Rossomando; Laura Silvian; Frank Porreca
New approaches for the treatment of pain: the GDNF family of neurotrophic growth factors.
Current topics in medicinal chemistry 2005;5(6):577-83.
2004: Shuxin Li; Betty P Liu; Stephane Budel; Mingwei Li; Benxiu Ji; Lee Walus; Weiwei Li; Adrienna Jirik; Sylvia A Rabacchi; Eugene Choi; Dane Worley; Dinah W Y Sah; Blake Pepinsky; Daniel Lee; Jane K Relton; Stephen M Strittmatter
Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(46):10511-20.
2004: Weiwei Li; Lee Walus; Sylvia A Rabacchi; Adrienna Jirik; Ernie Chang; Jessica Schauer; Betty H Zheng; Nancy J Benedetti; Betty P Liu; Eugene Choi; Dane Worley; Laura Silvian; Wenjun Mo; Colleen Mullen; Weixing Yang; Stephen M Strittmatter; Dinah W Y Sah; Blake Pepinsky; Daniel H S Lee
A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin.
The Journal of biological chemistry 2004;279(42):43780-8.
2003: Daniel H S Lee; Stephen M Strittmatter; Dinah W Y Sah
Targeting the Nogo receptor to treat central nervous system injuries.
Nature reviews. Drug discovery 2003;2(11):872-8.
2003: Luis R Gardell; Ruizhong Wang; Chris Ehrenfels; Michael H Ossipov; Anthony J Rossomando; Stephan Miller; Carolyn Buckley; Amber K Cai; Albert Tse; Susan F Foley; BangJian Gong; Lee Walus; Paul Carmillo; Dane Worley; Carol Huang; Thomas Engber; Blake Pepinsky; Richard L Cate; Todd W Vanderah; Josephine Lai; Dinah W Y Sah; Frank Porreca
Multiple actions of systemic artemin in experimental neuropathy.
Nature medicine 2003;9(11):1383-9.
2003: William A Barton; Betty P Liu; Dorothea Tzvetkova; Philip Jeffrey; Alyson E Fournier; Dinah W Y Sah; Richard Cate; Stephen M Strittmatter; Dimitar B Nikolov
Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.
The EMBO journal 2003;22(13):3291-302.
2003: Dinah W Y Sah; Michael H Ossipo; Frank Porreca
Neurotrophic factors as novel therapeutics for neuropathic pain.
Nature reviews. Drug discovery 2003;2(6):460-72.
2001: Olivia Orozco; Lee Walus; Dinah W Y Sah; R Blake Pepinsky; Michele Sanicola
GFRalpha3 is expressed predominantly in nociceptive sensory neurons.
The European journal of neuroscience 2001;13(11):2177-82.