Takaomi Saido

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Choi Yun-Sik; Lee Boyoung; Cho Hee-Yeon; Reyes Iza B; Pu Xin-An; Saido Takaomi C; Hoyt Kari R; Obrietan Karl
CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease.
Fujiwara Hironori; Tabuchi Masahiro; Yamaguchi Takuji; Iwasaki Koh; Furukawa Katsutoshi; Sekiguchi Kyoji; Ikarashi Yasushi; Kudo Yukitsuka; Higuchi Makoto; Saido Takaomi C; Maeda Sumihiro; Takashima Akihiko; Hara Masahiko; Yaegashi Nobuo; Kase Yoshio; Arai Hiroyuki
A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo.
Nakazawa Toru; Shimura Masahiko; Mourin Ryu; Kondo Mineo; Yokokura Shunji; Saido Takaomi C; Nishida Kohji; Endo Shogo
Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells.

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2009: Choi Yun-Sik; Lee Boyoung; Cho Hee-Yeon; Reyes Iza B; Pu Xin-An; Saido Takaomi C; Hoyt Kari R; Obrietan Karl
CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease.
Neurobiology of disease 2009;36(2):259-68.
2009: Fujiwara Hironori; Tabuchi Masahiro; Yamaguchi Takuji; Iwasaki Koh; Furukawa Katsutoshi; Sekiguchi Kyoji; Ikarashi Yasushi; Kudo Yukitsuka; Higuchi Makoto; Saido Takaomi C; Maeda Sumihiro; Takashima Akihiko; Hara Masahiko; Yaegashi Nobuo; Kase Yoshio; Arai Hiroyuki
A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo.
Journal of neurochemistry 2009;109(6):1648-57.
2009: Nakazawa Toru; Shimura Masahiko; Mourin Ryu; Kondo Mineo; Yokokura Shunji; Saido Takaomi C; Nishida Kohji; Endo Shogo
Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells.
Journal of neuroscience research 2009;87(6):1412-23.
2009: Adachi Atsuhiro; Kano Fumi; Saido Takaomi C; Murata Masayuki
Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(3):355-69.
2009: Suzuki Toshimitsu; Miyamoto Hiroyuki; Nakahari Takashi; Inoue Ikuyo; Suemoto Takahiro; Jiang Bin; Hirota Yuki; Itohara Shigeyoshi; Saido Takaomi C; Tsumoto Tadaharu; Sawamoto Kazunobu; Hensch Takao K; Delgado-Escueta Antonio V; Yamakawa Kazuhiro
Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility.
Human molecular genetics 2009;18(6):1099-109.
2009: Gonçalves Isabel; Nitulescu Mihaela; Saido Takaomi C; Dias Nuno; Pedro Luis M; E Fernandes José Fernandes; Ares Mikko P S; Pörn-Ares Isabella
Activation of calpain-1 in human carotid artery atherosclerotic lesions.
BMC cardiovascular disorders 2009;9():26.
2008: Cynis Holger; Scheel Eike; Saido Takaomi C; Schilling Stephan; Demuth Hans-Ulrich
Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.
Biochemistry 2008;47(28):7405-13.
2008: Wang Jiying; Ohno-Matsui Kyoko; Yoshida Takeshi; Kojima Ariko; Shimada Noriaki; Nakahama Ken-ichi; Safranova Olga; Iwata Nobuhisa; Saido Takaomi C; Mochizuki Manabu; Morita Ikuo
Altered function of factor I caused by amyloid beta: implication for pathogenesis of age-related macular degeneration from Drusen.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):712-20.
2008: Vetrivel Kulandaivelu S; Zhang Xulun; Meckler Xavier; Cheng Haipeng; Lee Sungho; Gong Ping; Lopes Kryslaine O; Chen Ying; Iwata Nobuhisa; Yin Ke-Jie; Lee Jin-Moo; Parent Angèle T; Saido Takaomi C; Li Yue-Ming; Sisodia Sangram S; Thinakaran Gopal
Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta.
The Journal of biological chemistry 2008;283(28):19489-98.
2008: Hirata-Fukae Chiho; Li Hui-Fang; Hoe Hyang-Sook; Gray Audrey J; Minami S Sakura; Hamada Katsuyoshi; Niikura Takako; Hua Fang; Tsukagoshi-Nagai Hiroe; Horikoshi-Sakuraba Yuko; Mughal Mohamed; Rebeck G William; LaFerla Frank M; Mattson Mark P; Iwata Nobuhisa; Saido Takaomi C; Klein William L; Duff Karen E; Aisen Paul S; Matsuoka Yasuji
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.
Brain research 2008;1216():92-103.
2008: Iwata Nobuhisa; Higuchi Makoto; Saido Takaomi C
[Therapeutic strategy by manipulating some protease activities for Alzheimer's disease]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2008;131(5):320-5.
2008: Tachida Yuriko; Nakagawa Kazuhiro; Saito Takashi; Saido Takaomi C; Honda Takashi; Saito Yuko; Murayama Shigeo; Endo Tamao; Sakaguchi Gaku; Kato Akira; Kitazume Shinobu; Hashimoto Yasuhiro
Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production.
Journal of neurochemistry 2008;104(5):1387-93.
2008: Nakajima Ryuichi; Takao Keizo; Huang Shu-Ming; Takano Jiro; Iwata Nobuhisa; Miyakawa Tsuyoshi; Saido Takaomi C
Comprehensive behavioral phenotyping of calpastatin-knockout mice.
Molecular brain 2008;1(1):7.
2007: Wirths Oliver; Weis Joachim; Kayed Rakez; Saido Takaomi C; Bayer Thomas A
Age-dependent axonal degeneration in an Alzheimer mouse model.
Neurobiology of aging 2007;28(11):1689-99.
2007: Maeda Jun; Ji Bin; Irie Toshiaki; Tomiyama Takami; Maruyama Masahiro; Okauchi Takashi; Staufenbiel Matthias; Iwata Nobuhisa; Ono Maiko; Saido Takaomi C; Suzuki Kazutoshi; Mori Hiroshi; Higuchi Makoto; Suhara Tetsuya
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(41):10957-68.
2007: Wang Jing; Pignol Bernadette; Chabrier Pierre-Etienne; Saido Takaomi; Lloyd Ruth; Tang Yong; Lenoir Marc; Puel Jean-Luc
A novel dual inhibitor of calpains and lipid peroxidation (BN82270) rescues the cochlea from sound trauma.
Neuropharmacology 2007;52(6):1426-37.
2007: Yoshiyama Yasumasa; Higuchi Makoto; Zhang Bin; Huang Shu-Ming; Iwata Nobuhisa; Saido Takaomi C; Maeda Jun; Suhara Tetsuya; Trojanowski John Q; Lee Virginia M-Y
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model.
Neuron 2007;53(3):337-51.
2007: Hori Yukiko; Hashimoto Tadafumi; Wakutani Yosuke; Urakami Katsuya; Nakashima Kenji; Condron Margaret M; Tsubuki Satoshi; Saido Takaomi C; Teplow David B; Iwatsubo Takeshi
The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation.
The Journal of biological chemistry 2007;282(7):4916-23.
2007: Asai Masashi; Iwata Nobuhisa; Yoshikawa Ayumu; Aizaki Yoshimi; Ishiura Shoichi; Saido Takaomi C; Maruyama Kei
Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion.
Biochemical and biophysical research communications 2007;352(2):498-502.
2007: Kamei Hirotsugu; Saito Taro; Ozawa Mirai; Fujita Yuichi; Asada Akiko; Bibb James A; Saido Takaomi C; Sorimachi Hiroyuki; Hisanaga Shin-Ichi
Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation.
The Journal of biological chemistry 2007;282(3):1687-94.
2006: Araya Runa; Noguchi Takanori; Yuhki Munehiro; Kitamura Naohito; Higuchi Makoto; Saido Takaomi C; Seki Kenjiro; Itohara Shigeyoshi; Kawano Masako; Tanemura Kentaro; Takashima Akihiko; Yamada Kazuyuki; Kondoh Yasushi; Kanno Iwao; Wess Jürgen; Yamada Masahisa
Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.
Neurobiology of disease 2006;24(2):334-44.
2006: Higuchi Makoto; Saido Takaomi C; Suhara Tetsuya
Animal models of tauopathies.
Neuropathology : official journal of the Japanese Society of Neuropathology 2006;26(5):491-7.
2006: Cynis Holger; Schilling Stephan; Bodnár Mandy; Hoffmann Torsten; Heiser Ulrich; Saido Takaomi C; Demuth Hans-Ulrich
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.
Biochimica et biophysica acta 2006;1764(10):1618-25.
2006: Hattori Chinatsu; Asai Masashi; Onishi Hayato; Sasagawa Noboru; Hashimoto Yasuhiro; Saido Takaomi C; Maruyama Kei; Mizutani Shigehiko; Ishiura Shoichi
BACE1 interacts with lipid raft proteins.
Journal of neuroscience research 2006;84(4):912-7.
2006: Fujiwara Hironori; Iwasaki Koh; Furukawa Katsutoshi; Seki Takashi; He Mei; Maruyama Masahiro; Tomita Naoki; Kudo Yukitsuka; Higuchi Makoto; Saido Takaomi C; Maeda Sumihiro; Takashima Akihiko; Hara Masahiko; Ohizumi Yasushi; Arai Hiroyuki
Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins.
Journal of neuroscience research 2006;84(2):427-33.
2006: Sato Toru; Nyborg Andrew C; Iwata Nobuhisa; Diehl Thekla S; Saido Takaomi C; Golde Todd E; Wolfe Michael S
Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs.
Biochemistry 2006;45(28):8649-56.
2006: Samura Eriko; Shoji Mikio; Kawarabayashi Takeshi; Sasaki Atsushi; Matsubara Etsuro; Murakami Tetsuro; Wuhua Xu; Tamura Shuta; Ikeda Masaki; Ishiguro Koich; Saido Takaomi C; Westaway David; St George Hyslop Peter; Harigaya Yasuo; Abe Koji
Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1.
Brain research 2006;1094(1):192-9.
2006: Huang Shu-Ming; Mouri Akihiro; Kokubo Hideko; Nakajima Ryuichi; Suemoto Takahiro; Higuchi Makoto; Staufenbiel Matthias; Noda Yukihiro; Yamaguchi Haruyasu; Nabeshima Toshitaka; Saido Takaomi C; Iwata Nobuhisa
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.
The Journal of biological chemistry 2006;281(26):17941-51.
2006: Saido Takaomi C; Iwata Nobuhisa
Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy.
Neuroscience research 2006;54(4):235-53.
2006: Zou Li-Bo; Mouri Akihiro; Iwata Nobuhisa; Saido Takaomi C; Wang Dayong; Wang Min-Wei; Mizoguchi Hiroyuki; Noda Yukihiro; Nabeshima Toshitaka
Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory.
The Journal of pharmacology and experimental therapeutics 2006;317(1):334-40.
2006: Mouri Akihiro; Zou Li-Bo; Iwata Nobuhisa; Saido Takaomi C; Wang Dayong; Wang Min-Wei; Noda Yukihiro; Nabeshima Toshitaka
Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory.
Behavioural brain research 2006;168(1):83-91.
2006: Nakagawa Kazuhiro; Kitazume Shinobu; Oka Ritsuko; Maruyama Kei; Saido Takaomi C; Sato Yuji; Endo Tamao; Hashimoto Yasuhiro
Sialylation enhances the secretion of neurotoxic amyloid-beta peptides.
Journal of neurochemistry 2006;96(4):924-33.
2006: Harigaya Yasuo; Tomidokoro Yasushi; Ikeda Masaki; Sasaki Atsushi; Kawarabayashi Takeshi; Matsubara Etsuro; Kanai Mitsuyasu; Saido Takaomi C; Younkin Steven G; Shoji Mikio
Type-specific evolution of amyloid plaque and angiopathy in APPsw mice.
Neuroscience letters 2006;395(1):37-41.
2006: Asai Masashi; Hattori Chinatsu; Iwata Nobuhisa; Saido Takaomi C; Sasagawa Noboru; Szabó Beáta; Hashimoto Yasuhiro; Maruyama Kei; Tanuma Sei-ichi; Kiso Yoshiaki; Ishiura Shoichi
The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
Journal of neurochemistry 2006;96(2):533-40.
2005: Iwata Nobuhisa; Saido Takaomi C; Mizukami Hiroaki; Ozawa Keiya
[Experimental gene therapy for Alzheimer's disease--animal models]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():691-8.
2005: Ogawa Tokiko; Kiryu-Seo Sumiko; Tanaka Masaaki; Konishi Hiroyuki; Iwata Nobuhisa; Saido Takaomi; Watanabe Yasuyoshi; Kiyama Hiroshi
Altered expression of neprilysin family members in the pituitary gland of sleep-disturbed rats, an animal model of severe fatigue.
Journal of neurochemistry 2005;95(4):1156-66.
2005: Thal Dietmar Rudolf; Capetillo-Zarate Estibaliz; Schultz Christian; Rüb Udo; Saido Takaomi C; Yamaguchi Haruyasu; Haass Christian; Griffin W Sue T; Del Tredici Kelly; Braak Heiko; Ghebremedhin Estifanos
Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner.
Acta neuropathologica 2005;110(5):459-71.
2005: Iwata Nobuhisa; Higuchi Makoto; Saido Takaomi C
Metabolism of amyloid-beta peptide and Alzheimer's disease.
Pharmacology & therapeutics 2005;108(2):129-48.
2005: Iwata Nobuhisa; Higuchi Makoto; Saito Takashi; Saido Takaomi C
[Presymptomatic diagnosis, prevention and therapy]
No to shinkei = Brain and nerve 2005;57(10):855-66.
2005: Yoshida Takeshi; Ohno-Matsui Kyoko; Ichinose Shizuko; Sato Tetsuji; Iwata Nobuhisa; Saido Takaomi C; Hisatomi Toshio; Mochizuki Manabu; Morita Ikuo
The potential role of amyloid beta in the pathogenesis of age-related macular degeneration.
The Journal of clinical investigation 2005;115(10):2793-800.
2005: Piccini Alessandra; Russo Claudio; Gliozzi Alessandra; Relini Annalisa; Vitali Antonella; Borghi Roberta; Giliberto Luca; Armirotti Andrea; D'Arrigo Cristina; Bachi Angela; Cattaneo Angela; Canale Claudio; Torrassa Silvia; Saido Takaomi C; Markesbery William; Gambetti Pierluigi; Tabaton Massimo
beta-amyloid is different in normal aging and in Alzheimer disease.
The Journal of biological chemistry 2005;280(40):34186-92.
2005: Higuchi Makoto; Iwata Nobuhisa; Saido Takaomi C
Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions.
Biochimica et biophysica acta 2005;1751(1):60-7.
2005: Maruyama Masahiro; Higuchi Makoto; Takaki Yoshie; Matsuba Yukio; Tanji Haruko; Nemoto Miyako; Tomita Naoki; Matsui Toshifumi; Iwata Nobuhisa; Mizukami Hiroaki; Muramatsu Shin-ichi; Ozawa Keiya; Saido Takaomi C; Arai Hiroyuki; Sasaki Hidetada
Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease.
Annals of neurology 2005;57(6):832-42.
2005: Kokubo Hideko; Kayed Rakez; Glabe Charles G; Saido Takaomi C; Iwata Nobuhisa; Helms J Bernd; Yamaguchi Haruyasu
Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain.
Brain research 2005;1045(1-2):224-8.
2005: Sato Toru; Tanimura Yu; Hirotani Naoko; Saido Takaomi C; Morishima-Kawashima Maho; Ihara Yasuo
Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.
FEBS letters 2005;579(13):2907-12.
2005: Kambe Atsushi; Yokota Masayuki; Saido Takaomi C; Satokata Ichiro; Fujikawa Hirokazu; Tabuchi Sadaharu; Kamitani Hideki; Watanabe Takashi
Spatial resolution of calpain-catalyzed proteolysis in focal cerebral ischemia.
Brain research 2005;1040(1-2):36-43.
2005: Saito Takashi; Iwata Nobuhisa; Tsubuki Satoshi; Takaki Yoshie; Takano Jiro; Huang Shu-Ming; Suemoto Takahiro; Higuchi Makoto; Saido Takaomi C
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.
Nature medicine 2005;11(4):434-9.
2005: Higuchi Makoto; Iwata Nobuhisa; Matsuba Yukio; Sato Kumi; Sasamoto Kazumi; Saido Takaomi C
19F and 1H MRI detection of amyloid beta plaques in vivo.
Nature neuroscience 2005;8(4):527-33.
2005: Higuchi Makoto; Tomioka Masanori; Takano Jiro; Shirotani Keiro; Iwata Nobuhisa; Masumoto Hajime; Maki Masatoshi; Itohara Shigeyoshi; Saido Takaomi C
Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.
The Journal of biological chemistry 2005;280(15):15229-37.
2005: Takano Jiro; Tomioka Masanori; Tsubuki Satoshi; Higuchi Makoto; Iwata Nobuhisa; Itohara Shigeyoshi; Maki Masatoshi; Saido Takaomi C
Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.
The Journal of biological chemistry 2005;280(16):16175-84.
2005: Kokubo Hideko; Saido Takaomi C; Iwata Nobuhisa; Helms J Bernd; Shinohara Rumi; Yamaguchi Haruyasu
Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain.
Neurobiology of aging 2005;26(4):409-18.
2005: Hayashi Masami; Koshihara Yasuko; Ishibashi Hideaki; Yamamoto Seizo; Tsubuki Satoshi; Saido Takaomi C; Kawashima Seiichi; Inomata Mitsushi
Involvement of calpain in osteoclastic bone resorption.
Journal of biochemistry 2005;137(3):331-8.
2005: Shin Ryong-Woon; Saido Takaomi C; Maeda Masahiro; Kitamoto Tetsuyuki
Novel alpha-secretase cleavage of Alzheimer's amyloid beta precursor protein in the endoplasmic reticulum of COS7 cells.
Neuroscience letters 2005;376(1):14-9.
2005: Qi-Takahara Yue; Morishima-Kawashima Maho; Tanimura Yu; Dolios Georgia; Hirotani Naoko; Horikoshi Yuko; Kametani Fuyuki; Maeda Masahiro; Saido Takaomi C; Wang Rong; Ihara Yasuo
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(2):436-45.
2005: Bialkowska Katarzyna; Saido Takaomi C; Fox Joan E B
SH3 domain of spectrin participates in the activation of Rac in specialized calpain-induced integrin signaling complexes.
Journal of cell science 2005;118(Pt 2):381-95.
2005: Hama E; Saido T C
Etiology of sporadic Alzheimer's disease: somatostatin, neprilysin, and amyloid beta peptide.
Medical hypotheses 2005;65(3):498-500.
2004: Saido Takaomi C
[Towards presymptomatic diagnosis, prevention and treatment of Alzheimer's disease]
Rinsho shinkeigaku = Clinical neurology 2004;44(11):775-7.
2004: Kitazume Shinobu; Kotani Norihiro; Nakato Hiroshi; Saido Takaomi; Hashimoto Yasuhiro
[Glycosyltransferases as substrates for Alzheimer's beta-secretase]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2004;49(15 Suppl):2468-72.
2004: Funamoto Satoru; Morishima-Kawashima Maho; Tanimura Yu; Hirotani Naoko; Saido Takaomi C; Ihara Yasuo
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.
Biochemistry 2004;43(42):13532-40.
2004: Ladrech Sabine; Guitton Matthieu; Saido Takaomi; Lenoir Marc
Calpain activity in the amikacin-damaged rat cochlea.
The Journal of comparative neurology 2004;477(2):149-60.
2004: Sato Kumi; Higuchi Makoto; Iwata Nobuhisa; Saido Takaomi C; Sasamoto Kazumi
Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques.
European journal of medicinal chemistry 2004;39(7):573-8.
2004: Wakutani Y; Watanabe K; Adachi Y; Wada-Isoe K; Urakami K; Ninomiya H; Saido T C; Hashimoto T; Iwatsubo T; Nakashima K
Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2004;75(7):1039-42.
2004: Hama Emi; Shirotani Keiro; Iwata Nobuhisa; Saido Takaomi C
Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons.
The Journal of biological chemistry 2004;279(29):30259-64.
2004: Kimura Tooru; Shuto Daisuke; Kasai Soko; Liu Ping; Hidaka Koushi; Hamada Takashi; Hayashi Yoshio; Hattori Chinatsu; Asai Masashi; Kitazume Shinobu; Saido Takaomi C; Ishiura Shoichi; Kiso Yoshiaki
KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine.
Bioorganic & medicinal chemistry letters 2004;14(6):1527-31.
2004: Iwata Nobuhisa; Mizukami Hiroaki; Shirotani Keiro; Takaki Yoshie; Muramatsu Shin-ichi; Lu Bao; Gerard Norma P; Gerard Craig; Ozawa Keiya; Saido Takaomi C
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(4):991-8.
2004: Kitazume Shinobu; Suzuki Minoru; Saido Takaomi C; Hashimoto Yasuhiro
Involvement of proteases in glycosyltransferase secretion: Alzheimer's beta-secretase-dependent cleavage and a following processing by an aminopeptidase.
Glycoconjugate journal 2004;21(1-2):25-9.
2004: Kitazume Shinobu; Saido Takaomi C; Hashimoto Yasuhiro
Alzheimer's beta-secretase cleaves a glycosyltransferase as a physiological substrate.
Glycoconjugate journal 2004;20(1):59-62.
2003: Inoue Haruhisa; Tsukita Kayoko; Iwasato Takuji; Suzuki Yasuyuki; Tomioka Masanori; Tateno Minako; Nagao Masahiro; Kawata Akihiro; Saido Takaomi C; Miura Masayuki; Misawa Hidemi; Itohara Shigeyoshi; Takahashi Ryosuke
The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model.
The EMBO journal 2003;22(24):6665-74.
2003: Rami A; Volkmann T; Agarwal R; Schoninger S; Nürnberger F; Saido T C; Winckler J
beta2-Adrenergic receptor responsiveness of the calpain-calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia.
Neuroscience research 2003;47(4):373-82.
2003: Wang Deng-Shun; Iwata Nobuhisa; Hama Emi; Saido Takaomi C; Dickson Dennis W
Oxidized neprilysin in aging and Alzheimer's disease brains.
Biochemical and biophysical research communications 2003;310(1):236-41.
2003: Yokota Masayuki; Saido Takaomi C; Kamitani Hideki; Tabuchi Sadaharu; Satokata Ichiro; Watanabe Takashi
Calpain induces proteolysis of neuronal cytoskeleton in ischemic gerbil forebrain.
Brain research 2003;984(1-2):122-32.
2003: Pörn-Ares M Isabella; Saido Takaomi C; Andersson Tommy; Ares Mikko P S
Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells.
The Biochemical journal 2003;374(Pt 2):403-11.
2003: Iwata Nobuhisa; Saido Takaomi C
[Amyloid-beta peptide metabolism and Alzheimer's disease]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(1):5-14.
2003: Kitazume-Kawaguchi Shinobu; Hashimoto Yasuhiro; Saido Takaomi
[BACE1 and glycosyltransferases]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2003;48(8 Suppl):984-9.
2003: Tsubuki Satoshi; Takaki Yoshie; Saido Takaomi C
Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation.
Lancet 2003;361(9373):1957-8.
2003: Zhang Jian; Miyamoto Ken-ichiro; Hashioka Sadayuki; Hao Hai Peng; Murao Koji; Saido Takaomi C; Nakanishi Hiroshi
Activation of mu-calpain in developing cortical neurons following methylmercury treatment.
Brain research. Developmental brain research 2003;142(1):105-10.
2003: Kitazume Shinobu; Tachida Yuriko; Oka Ritsuko; Kotani Norihiro; Ogawa Kazuko; Suzuki Minoru; Dohmae Naoshi; Takio Koji; Saido Takaomi C; Hashimoto Yasuhiro
Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).
The Journal of biological chemistry 2003;278(17):14865-71.
2003: Saito Takashi; Takaki Yoshie; Iwata Nobuhisa; Trojanowski John; Saido Takaomi C
Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism.
Science of aging knowledge environment : SAGE KE 2003;2003(3):PE1.
2003: Yamashima Tetsumori; Tonchev Anton B; Tsukada Toshiyuki; Saido Takaomi C; Imajoh-Ohmi Shinobu; Momoi Takashi; Kominami Eiki
Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates.
Hippocampus 2003;13(7):791-800.
2002: Tomioka Masanori; Shirotani Keiro; Iwata Nobuhisa; Lee Hahn-Jun; Yang Fusheng; Cole Greg M; Seyama Yousuke; Saido Takaomi C
In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons.
Brain research. Molecular brain research 2002;108(1-2):18-32.
2002: Kuwako Ken-ichiro; Nishimura Isao; Uetsuki Taichi; Saido Takaomi C; Yoshikawa Kazuaki
Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein.
Brain research. Molecular brain research 2002;107(2):166-75.
2002: Iwata Nobuhisa; Takaki Yoshie; Fukami Shinjiro; Tsubuki Satoshi; Saido Takaomi C
Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.
Journal of neuroscience research 2002;70(3):493-500.
2002: Kitazume Shinobu; Saido Takaomi C; Hashimoto Yasuhiro
[Identification of a novel substrate of Alzheimer's beta-secretase: beta-secretase dependent cleavage of alpha 2,6 sialyltransferase]
Seikagaku. The Journal of Japanese Biochemical Society 2002;74(9):1180-3.
2002: Takahashi Megumi; Fukami Shinjiro; Iwata Nobuhisa; Inoue Keiichi; Itohara Shigeyoshi; Itoh Hiroshi; Haraoka Jo; Saido Takaomi
In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture.
Pharmacological research : the official journal of the Italian Pharmacological Society 2002;46(2):155-63.
2002: Shirotani Keiro; Tsubuki Satoshi; Lee Hahn-Jun; Maruyama Kei; Saido Takaomi C
Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons.
Neuroscience letters 2002;327(1):25-8.
2002: Fukami Shinjiro; Watanabe Kaori; Iwata Nobuhisa; Haraoka Jo; Lu Bao; Gerard Norma P; Gerard Craig; Fraser Paul; Westaway David; St George-Hyslop Peter; Saido Takaomi C
Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.
Neuroscience research 2002;43(1):39-56.
2002: Hattori Chinatsu; Asai Masashi; Oma Yoko; Kino Yoshihiro; Sasagawa Noboru; Saido Takaomi C; Maruyama Kei; Ishiura Shoichi
BACE1 interacts with nicastrin.
Biochemical and biophysical research communications 2002;293(4):1228-32.
2002: Daré Elisabetta; Tofighi Roshan; Vettori Maria Vittoria; Momoi Takashi; Poli Diana; Saido Takaomi C; Mutti Antonio; Ceccatelli Sandra
Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells.
Brain research 2002;933(1):12-22.
2001: Kim J E; Han B S; Choi W S; Eom D S; Lee E H; Oh T H; Markelonis G J; Saido T C; Lee G E; Chung I K; Oh Y J
Temporospatial sequence of cellular events associated with etoposide-induced neuronal cell death: role of antiapoptotic protein Bcl-X(L).
Journal of neuroscience research 2001;66(6):1074-82.
2001: Hama E; Shirotani K; Masumoto H; Sekine-Aizawa Y; Aizawa H; Saido T C
Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons.
Journal of biochemistry 2001;130(6):721-6.
2001: Kaneko T; Yamashima T; Tohma Y; Nomura M; Imajoh-Ohmi S; Saido T C; Nakao M; Saya H; Yamamoto H; Yamashita J
Calpain-dependent proteolysis of merlin occurs by oxidative stress in meningiomas: a novel hypothesis of tumorigenesis.
Cancer 2001;92(10):2662-72.
2001: Kitazume S; Tachida Y; Oka R; Shirotani K; Saido T C; Hashimoto Y
Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13554-9.
2001: Morishima-Kawashima M; Saido T C; Ihara Y
[Alzheimer's disease and the proteins]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2001;46(11 Suppl):1798-804.
2001: Choi W S; Lee E H; Chung C W; Jung Y K; Jin B K; Kim S U; Oh T H; Saido T C; Oh Y J
Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2.
Journal of neurochemistry 2001;77(6):1531-41.
2001: Shirotani K; Tsubuki S; Iwata N; Takaki Y; Harigaya W; Maruyama K; Kiryu-Seo S; Kiyama H; Iwata H; Tomita T; Iwatsubo T; Saido T C
Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.
The Journal of biological chemistry 2001;276(24):21895-901.
2001: Iwata N; Tsubuki S; Takaki Y; Shirotani K; Lu B; Gerard N P; Gerard C; Hama E; Lee H J; Saido T C
Metabolic regulation of brain Abeta by neprilysin.
Science (New York, N.Y.) 2001;292(5521):1550-2.
2001: Sekine-Aizawa Y; Hama E; Watanabe K; Tsubuki S; Kanai-Azuma M; Kanai Y; Arai H; Aizawa H; Iwata N; Saido T C
Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellum.
The European journal of neuroscience 2001;13(5):935-48.
2001: Taniguchi S; Fujita Y; Hayashi S; Kakita A; Takahashi H; Murayama S; Saido T C; Hisanaga S; Iwatsubo T; Hasegawa M
Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.
FEBS letters 2001;489(1):46-50.
2001: Kawarabayashi T; Younkin L H; Saido T C; Shoji M; Ashe K H; Younkin S G
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(2):372-81.
2000: Takaki Y; Iwata N; Tsubuki S; Taniguchi S; Toyoshima S; Lu B; Gerard N P; Gerard C; Lee H J; Shirotani K; Saido T C
Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain.
Journal of biochemistry 2000;128(6):897-902.
2000: Bialkowska K; Kulkarni S; Du X; Goll D E; Saido T C; Fox J E
Evidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become active.
The Journal of cell biology 2000;151(3):685-96.
2000: Harigaya Y; Saido T C; Eckman C B; Prada C M; Shoji M; Younkin S G
Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain.
Biochemical and biophysical research communications 2000;276(2):422-7.
2000: Lee H J; Tomioka M; Takaki Y; Masumoto H; Saido T C
Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus.
Biochimica et biophysica acta 2000;1493(1-2):273-8.
2000: Koike H; Kouchi Z; Kinouchi T; Maeda T; Sorimachi H; Saido T C; Maruyama K; Okuyama A; Suzuki K; Ishiura S
Metabolism of amyloid precursor protein in COS cells transfected with a beta-secretase candidate.
Cytotechnology 2000;33(1-3):213-9.
2000: Takeuchi A; Irizarry M C; Duff K; Saido T C; Hsiao Ashe K; Hasegawa M; Mann D M; Hyman B T; Iwatsubo T
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.
The American journal of pathology 2000;157(1):331-9.
2000: Russo C; Schettini G; Saido T C; Hulette C; Lippa C; Lannfelt L; Ghetti B; Gambetti P; Tabaton M; Teller J K
Presenilin-1 mutations in Alzheimer's disease.
Nature 2000;405(6786):531-2.
2000: Lankiewicz S; Marc Luetjens C; Truc Bui N; Krohn A J; Poppe M; Cole G M; Saido T C; Prehn J H
Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death.
The Journal of biological chemistry 2000;275(22):17064-71.
2000: Nakagawa Y; Reed L; Nakamura M; McIntosh T K; Smith D H; Saatman K E; Raghupathi R; Clemens J; Saido T C; Lee V M; Trojanowski J Q
Brain trauma in aged transgenic mice induces regression of established abeta deposits.
Experimental neurology 2000;163(1):244-52.
2000: Shoji M; Kawarabayashi T; Sato M; Sasaki A; Saido T C; Matsubara E; Tomidokoro Y; Kanai M; Shizuka M; Ishiguro K; Ikeda M; Harigaya Y; Okamoto K; Hirai S
Age-related amyloid beta protein accumulation induces cellular death and macrophage activation in transgenic mice.
The Journal of pathology 2000;191(1):93-101.
2000: Kitagaki H; Tomioka S; Yoshizawa T; Sorimachi H; Saido T C; Ishiura S; Suzuki K
Autolysis of calpain large subunit inducing irreversible dissociation of stoichiometric heterodimer of calpain.
Bioscience, biotechnology, and biochemistry 2000;64(4):689-95.
2000: Saido T C
Involvement of polyglutamine endolysis followed by pyroglutamate formation in the pathogenesis of triplet repeat/polyglutamine-expansion diseases.
Medical hypotheses 2000;54(3):427-9.
2000: Maruyama K; Usami M; Kametani F; Tomita T; Iwatsubo T; Saido T C; Mori H; Ishiura S
Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain.
International journal of molecular medicine 2000;5(3):269-73.
2000: Iwata N; Tsubuki S; Takaki Y; Watanabe K; Sekiguchi M; Hosoki E; Kawashima-Morishima M; Lee H J; Hama E; Sekine-Aizawa Y; Saido T C
Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition.
Nature medicine 2000;6(2):143-50.
1999: Schmidt M L; Saido T C; Lee V M; Trojanowski J Q
Spatial relationship of AMY protein deposits and different species of Abeta peptides in amyloid plaques of the Alzheimer disease brain.
Journal of neuropathology and experimental neurology 1999;58(12):1227-33.
1999: Tomita T; Takikawa R; Koyama A; Morohashi Y; Takasugi N; Saido T C; Maruyama K; Iwatsubo T
C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(24):10627-34.
1999: Hayashi M; Suzuki H; Kawashima S; Saido T C; Inomata M
The behavior of calpain-generated N- and C-terminal fragments of talin in integrin-mediated signaling pathways.
Archives of biochemistry and biophysics 1999;371(2):133-41.
1999: Koike H; Tomioka S; Sorimachi H; Saido T C; Maruyama K; Okuyama A; Fujisawa-Sehara A; Ohno S; Suzuki K; Ishiura S
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein.
The Biochemical journal 1999;343 Pt 2():371-5.
1999: Fukumoto H; Tomita T; Matsunaga H; Ishibashi Y; Saido T C; Iwatsubo T
Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid beta peptides ending at A beta40 and A beta42.
Neuroreport 1999;10(14):2965-9.
1999: Shields D C; Schaecher K E; Saido T C; Banik N L
A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11486-91.
1999: McGowan E; Sanders S; Iwatsubo T; Takeuchi A; Saido T; Zehr C; Yu X; Uljon S; Wang R; Mann D; Dickson D; Duff K
Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes.
Neurobiology of disease 1999;6(4):231-44.
1999: Nakagawa Y; Nakamura M; McIntosh T K; Rodriguez A; Berlin J A; Smith D H; Saatman K E; Raghupathi R; Clemens J; Saido T C; Schmidt M L; Lee V M; Trojanowski J Q
Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging.
The Journal of comparative neurology 1999;411(3):390-8.
1999: Kulkarni S; Saido T C; Suzuki K; Fox J E
Calpain mediates integrin-induced signaling at a point upstream of Rho family members.
The Journal of biological chemistry 1999;274(30):21265-75.
1999: Koike H; Seki H; Kouchi Z; Ito M; Kinouchi T; Tomioka S; Sorimachi H; Saido T C; Maruyama K; Suzuki K; Ishiura S
Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells.
Journal of biochemistry 1999;126(1):235-42.
1999: Blomgren K; Hallin U; Andersson A L; Puka-Sundvall M; Bahr B A; McRae A; Saido T C; Kawashima S; Hagberg H
Calpastatin is up-regulated in response to hypoxia and is a suicide substrate to calpain after neonatal cerebral hypoxia-ischemia.
The Journal of biological chemistry 1999;274(20):14046-52.
1999: Kitagawa K; Matsumoto M; Saido T C; Ohtsuki T; Kuwabara K; Yagita Y; Mabuchi T; Yanagihara T; Hori M
Species differences in fodrin proteolysis in the ischemic brain.
Journal of neuroscience research 1999;55(5):643-9.
1999: Yokota M; Tani E; Tsubuki S; Yamaura I; Nakagaki I; Hori S; Saido T C
Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage.
Brain research 1999;819(1-2):8-14.
1999: Akiyama H; Mori H; Saido T; Kondo H; Ikeda K; McGeer P L
Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease.
Glia 1999;25(4):324-31.
1999: Honda T; Yasutake K; Nihonmatsu N; Mercken M; Takahashi H; Murayama O; Murayama M; Sato K; Omori A; Tsubuki S; Saido T C; Takashima A
Dual roles of proteasome in the metabolism of presenilin 1.
Journal of neurochemistry 1999;72(1):255-61.
1999: Ray S K; Shields D C; Saido T C; Matzelle D C; Wilford G G; Hogan E L; Banik N L
Calpain activity and translational expression increased in spinal cord injury.
Brain research 1999;816(2):375-80.
1998: Hosoda R; Saido T C; Otvos L; Arai T; Mann D M; Lee V M; Trojanowski J Q; Iwatsubo T
Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains.
Journal of neuropathology and experimental neurology 1998;57(11):1089-95.
1998: Frautschy S A; Horn D L; Sigel J J; Harris-White M E; Mendoza J J; Yang F; Saido T C; Cole G M
Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8311-21.
1998: Sudoh S; Kawamura Y; Sato S; Wang R; Saido T C; Oyama F; Sakaki Y; Komano H; Yanagisawa K
Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.
Journal of neurochemistry 1998;71(4):1535-43.
1998: Tomita T; Tokuhiro S; Hashimoto T; Aiba K; Saido T C; Maruyama K; Iwatsubo T
Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.
The Journal of biological chemistry 1998;273(33):21153-60.
1998: Oyama F; Sawamura N; Kobayashi K; Morishima-Kawashima M; Kuramochi T; Ito M; Tomita T; Maruyama K; Saido T C; Iwatsubo T; Capell A; Walter J; Grünberg J; Ueyama Y; Haass C; Ihara Y
Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Journal of neurochemistry 1998;71(1):313-22.
1998: Ono Y; Shimada H; Sorimachi H; Richard I; Saido T C; Beckmann J S; Ishiura S; Suzuki K
Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A.
The Journal of biological chemistry 1998;273(27):17073-8.
1998: Shinozaki K; Maruyama K; Kume H; Tomita T; Saido T C; Iwatsubo T; Obata K
The presenilin 2 loop domain interacts with the mu-calpain C-terminal region.
International journal of molecular medicine 1998;1(5):797-9.
1998: Zalewska T; Zablocka B; Saido T C; Zajac H; Domanska-Janik K
Dual response of calpain to rat brain postdecapitative ischemia.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1998;33(3):185-97.
1998: Funato H; Yoshimura M; Yamazaki T; Saido T C; Ito Y; Yokofujita J; Okeda R; Ihara Y
Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain.
The American journal of pathology 1998;152(4):983-92.
1998: Yamaguchi H; Sugihara S; Ogawa A; Saido T C; Ihara Y
Diffuse plaques associated with astroglial amyloid beta protein, possibly showing a disappearing stage of senile plaques.
Acta neuropathologica 1998;95(3):217-22.
1998: Tokuhiro S; Tomita T; Iwata H; Kosaka T; Saido T C; Maruyama K; Iwatsubo T
The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells.
Biochemical and biophysical research communications 1998;244(3):751-5.
1998: Schmidt M L; Lee V M; Saido T; Perl D; Schuck T; Iwatsubo T; Trojanowski J Q
Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging.
Acta neuropathologica 1998;95(2):117-22.
1998: Tekirian T L; Saido T C; Markesbery W R; Russell M J; Wekstein D R; Patel E; Geddes J W
N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits.
Journal of neuropathology and experimental neurology 1998;57(1):76-94.
1998: Saido T C
Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid.
Neurobiology of aging 1998;19(1 Suppl):S69-75.
1998: Frautschy S A; Yang F; Irrizarry M; Hyman B; Saido T C; Hsiao K; Cole G M
Microglial response to amyloid plaques in APPsw transgenic mice.
The American journal of pathology 1998;152(1):307-17.
1997: Shin R W; Ogino K; Kondo A; Saido T C; Trojanowski J Q; Kitamoto T; Tateishi J
Amyloid beta-protein (Abeta) 1-40 but not Abeta1-42 contributes to the experimental formation of Alzheimer disease amyloid fibrils in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(21):8187-93.
1997: Blomgren K; McRae A; Elmered A; Bona E; Kawashima S; Saido T C; Ono T; Hagberg H
The calpain proteolytic system in neonatal hypoxic-ischemia.
Annals of the New York Academy of Sciences 1997;825():104-19.
1997: Saido T C; Yokota M
[Neurodegenerative diseases as proteolytic disorders: brain ischemia and Alzheimer's disease]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(14 Suppl):2408-17.
1997: Yan S D; Fu J; Soto C; Chen X; Zhu H; Al-Mohanna F; Collison K; Zhu A; Stern E; Saido T; Tohyama M; Ogawa S; Roher A; Stern D
An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.
Nature 1997;389(6652):689-95.
1997: Yamazaki T; Haass C; Saido T C; Omura S; Ihara Y
Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition.
Biochemistry 1997;36(27):8377-83.
1997: Russo C; Saido T C; DeBusk L M; Tabaton M; Gambetti P; Teller J K
Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Down's syndrome brains.
FEBS letters 1997;409(3):411-6.
1997: Saido T C; Kawashima S; Tani E; Yokota M
Up- and down-regulation of calpain inhibitor polypeptide, calpastatin, in postischemic hippocampus.
Neuroscience letters 1997;227(2):75-8.
1997: Tomita T; Maruyama K; Saido T C; Kume H; Shinozaki K; Tokuhiro S; Capell A; Walter J; Grünberg J; Haass C; Iwatsubo T; Obata K
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):2025-30.
1997: Kuda T; Shoji M; Arai H; Kawashima S; Saido T C
Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer's disease.
Biochemical and biophysical research communications 1997;231(3):526-30.
1997: Mann D M; Pickering-Brown S M; Bayatti N N; Wright A E; Owen F; Iwatsubo T; Saido T C
An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid beta protein deposited in Alzheimer's disease.
Neuroscience letters 1997;222(1):57-60.
1997: Mann D M; Iwatsubo T; Pickering-Brown S M; Owen F; Saido T C; Perry R H
Preferential deposition of amyloid beta protein (Abeta) in the form Abeta40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele.
Neuroscience letters 1997;221(2-3):81-4.
1996: Iwatsubo T; Saido T C; Mann D M; Lee V M; Trojanowski J Q
Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.
The American journal of pathology 1996;149(6):1823-30.
1996: Yokota M; Saido T C; Tani E; Yamaura I; Minami N
Cytotoxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(6):1219-23.
1996: Maruyama K; Tomita T; Shinozaki K; Kume H; Asada H; Saido T C; Ishiura S; Iwatsubo T; Obata K
Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).
Biochemical and biophysical research communications 1996;227(3):730-5.
1996: Lemere C A; Lopera F; Kosik K S; Lendon C L; Ossa J; Saido T C; Yamaguchi H; Ruiz A; Martinez A; Madrigal L; Hincapie L; Arango J C; Anthony D C; Koo E H; Goate A M; Selkoe D J; Arango J C
The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.
Nature medicine 1996;2(10):1146-50.
1996: Saido T C
[Spatial resolution of proteolytic reactions in brain ischemia and Alzheimer's disease]
Seikagaku. The Journal of Japanese Biochemical Society 1996;68(9):1507-22.
1996: Yamashima T; Saido T C; Takita M; Miyazawa A; Yamano J; Miyakawa A; Nishijyo H; Yamashita J; Kawashima S; Ono T; Yoshioka T
Transient brain ischaemia provokes Ca2+, PIP2 and calpain responses prior to delayed neuronal death in monkeys.
The European journal of neuroscience 1996;8(9):1932-44.
1996: Saido T C; Yamao-Harigaya W; Iwatsubo T; Kawashima S
Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain.
Neuroscience letters 1996;215(3):173-6.
1996: Saito Y; Maruyama K; Kawano H; Hagino-Yamagishi K; Kawamura K; Saido T C; Kawashima S
Molecular cloning and characterization of a novel form of neuropeptide gene as a developmentally regulated molecule.
The Journal of biological chemistry 1996;271(26):15615-22.
1996: Lemere C A; Blusztajn J K; Yamaguchi H; Wisniewski T; Saido T C; Selkoe D J
Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.
Neurobiology of disease 1996;3(1):16-32.
1996: Kume H; Maruyama K; Tomita T; Iwatsubo T; Saido T C; Obata K
Molecular cloning of a novel basic helix-loop-helix protein from the rat brain.
Biochemical and biophysical research communications 1996;219(2):526-30.
1995: Saito Y; Maruyama K; Saido T C; Kawashima S
N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin.
Biochemical and biophysical research communications 1995;217(2):539-45.
1995: Bednarski E; Vanderklish P; Gall C; Saido T C; Bahr B A; Lynch G
Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices.
Brain research 1995;694(1-2):147-57.
1995: Yokota M; Saido T C; Tani E; Kawashima S; Suzuki K
Three distinct phases of fodrin proteolysis induced in postischemic hippocampus. Involvement of calpain and unidentified protease.
Stroke; a journal of cerebral circulation 1995;26(10):1901-7.
1995: Vanderklish P; Saido T C; Gall C; Arai A; Lynch G
Proteolysis of spectrin by calpain accompanies theta-burst stimulation in cultured hippocampal slices.
Brain research. Molecular brain research 1995;32(1):25-35.
1995: Blomgren K; Kawashima S; Saido T C; Karlsson J O; Elmered A; Hagberg H
Fodrin degradation and subcellular distribution of calpains after neonatal rat cerebral hypoxic-ischemia.
Brain research 1995;684(2):143-9.
1995: Harigaya Y; Shoji M; Kawarabayashi T; Kanai M; Nakamura T; Iizuka T; Igeta Y; Saido T C; Sahara N; Mori H
Modified amyloid beta protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer's disease.
Biochemical and biophysical research communications 1995;211(3):1015-22.
1995: Mizuno K; Noda K; Ueda Y; Hanaki H; Saido T C; Ikuta T; Kuroki T; Tamaoki T; Hirai S; Osada S
UCN-01, an anti-tumor drug, is a selective inhibitor of the conventional PKC subfamily.
FEBS letters 1995;359(2-3):259-61.
1995: Saido T C; Iwatsubo T; Mann D M; Shimada H; Ihara Y; Kawashima S
Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.
Neuron 1995;14(2):457-66.
1994: Saito Y; Saido T C; Sano K; Kawashima S
The calpain-calpastatin system is regulated differently during human neuroblastoma cell differentiation to Schwannian and neuronal cells.
FEBS letters 1994;353(3):327-31.
1994: Saido T C; Yokota M; Maruyama K; Yamao-Harigaya W; Tani E; Ihara Y; Kawashima S
Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus.
The Journal of biological chemistry 1994;269(21):15253-7.
1994: Sorimachi H; Saido T C; Suzuki K
New era of calpain research. Discovery of tissue-specific calpains.
FEBS letters 1994;343(1):1-5.
1994: Yokota M; Saido T C; Miyaji K; Tani E; Kawashima S; Suzuki K
Stimulation of protein-tyrosine phosphorylation in gerbil hippocampus after global forebrain ischemia.
Neuroscience letters 1994;168(1-2):69-72.
1993: Saido T C; Yokota M; Nagao S; Yamaura I; Tani E; Tsuchiya T; Suzuki K; Kawashima S
Spatial resolution of fodrin proteolysis in postischemic brain.
The Journal of biological chemistry 1993;268(33):25239-43.
1993: Yamaura I; Tani E; Saido T C; Suzuki K; Minami N; Maeda Y
Calpain-calpastatin system of canine basilar artery in vasospasm.
Journal of neurosurgery 1993;79(4):537-43.
1993: Sorimachi H; Toyama-Sorimachi N; Saido T C; Kawasaki H; Sugita H; Miyasaka M; Arahata K; Ishiura S; Suzuki K
Muscle-specific calpain, p94, is degraded by autolysis immediately after translation, resulting in disappearance from muscle.
The Journal of biological chemistry 1993;268(14):10593-605.
1992: Suzuki K; Saido T C; Hirai S
Modulation of cellular signals by calpain.
Annals of the New York Academy of Sciences 1992;674():218-27.
1992: Kawashima S; Saido T C
[Physiological function of calpains]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1992;37(12):2144-60.
1992: Saido T C; Mizuno K; Konno Y; Osada S; Ohno S; Suzuki K
Purification and characterization of protein kinase C epsilon from rabbit brain.
Biochemistry 1992;31(2):482-90.
1991: Mizuno K; Kubo K; Saido T C; Akita Y; Osada S; Kuroki T; Ohno S; Suzuki K
Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta.
European journal of biochemistry / FEBS 1991;202(3):931-40.
1991: Mori A; Aizawa H; Saido T C; Kawasaki H; Mizuno K; Murofushi H; Suzuki K; Sakai H
Site-specific phosphorylation by protein kinase C inhibits assembly-promoting activity of microtubule-associated protein 4.
Biochemistry 1991;30(38):9341-6.
1990: Saido T C; Suzuki K
[Calcium-activated neutral proteases in cell injury]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1990;35(10):1864-70.
1990: Kobayashi Y; Yamamoto K; Saido T; Kawasaki H; Oppenheim J J; Matsushima K
Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5548-52.
1987: Saido T C; Toyoshima S; Osawa T
Protein-O-carboxylmethyltransferase from cytosol and membranes of chicken erythrocytes.
Journal of biochemistry 1987;102(2):319-26.

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