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Takaomi Saido

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Chemicals & Drugs

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Jeannette Hübener; Fabronia Murad; Peter Bellstedt; Peter Breuer; Lisa Honold; Francois Paquet-Durand; Claudia Richter; Olaf Riess; Takaomi C Saido; Jiro Takano; Jonasz Jeremiasz Weber; Andreas Weiss; Ullrich Wüllner; Huu-Phuc Nguyen
Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).
Nobuhisa Iwata; Bin Ji; Shin-ichi Muramatsu; Masashi Asai; Yoshino Hattori; Makoto Higuchi; Misaki Sekiguchi; Matthias Staufenbiel; Akane Takahashi; Takaomi C Saido
Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice.
Naomasa Kakiya; Yukio Matsuba; Hiroyuki Nawa; Per Nilsson; Takashi Saito; Nobuyuki Takei; Satoshi Tsubuki; Takaomi C Saido
Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.

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2013: Jeannette Hübener; Fabronia Murad; Peter Bellstedt; Peter Breuer; Lisa Honold; Francois Paquet-Durand; Claudia Richter; Olaf Riess; Takaomi C Saido; Jiro Takano; Jonasz Jeremiasz Weber; Andreas Weiss; Ullrich Wüllner; Huu-Phuc Nguyen
Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).
Human molecular genetics 2013;22(3):508-18.
2013: Nobuhisa Iwata; Bin Ji; Shin-ichi Muramatsu; Masashi Asai; Yoshino Hattori; Makoto Higuchi; Misaki Sekiguchi; Matthias Staufenbiel; Akane Takahashi; Takaomi C Saido
Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice.
Scientific reports 2013;3():1472.
2012: Naomasa Kakiya; Yukio Matsuba; Hiroyuki Nawa; Per Nilsson; Takashi Saito; Nobuyuki Takei; Satoshi Tsubuki; Takaomi C Saido
Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.
The Journal of biological chemistry 2012;287(35):29362-72.
2012: Kathleen M Schoch; Jiro Takano; Takaomi C Saido; Jennifer M Brelsfoard; Heather N Evans; Sindhu K Madathil; Kathryn E Saatman
Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury.
Experimental neurology 2012;236(2):371-82.
2012: Makoto Higuchi; Nobuhisa Iwata; Bin Ji; Jun Maeda; Yukio Matsuba; Maiko Ono; Matthias Staufenbiel; Takahiro Suemoto; Tetsuya Suhara; Jiro Takano; Takaomi C Saido
Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(3):1204-17.
2012: Dorothee Abramowski; Estibaliz Capetillo-Zarate; Simone Danner; Sabine Rabe; Julia Reichwald; Takaomi C Saido; Dieter Staab; Dietmar R Thal; Ajeet Rijal Upadhaya; Karl-Heinz Wiederhold; Haruyasu Yamaguchi; Matthias Staufenbiel
Transgenic expression of intraneuronal Aβ42 but not Aβ40 leads to cellular Aβ lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(4):1273-83.
2012: Takenari Yamashita; Takaomi C Saido; Jiro Takano; Sayaka Teramoto; Kosuke Hachiga; Takuto Hideyama; Nobuhisa Iwata; Shin Kwak
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.
Nature communications 2012;3():1307.
2011: Jiro Takano; Athar H Chishti; Ryo Fujioka; Emi Hosoki; Naomi Mihira; Takaomi C Saido
Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.
Molecular and cellular biology 2011;31(19):4097-106.
2011: Masashi Asai; Shoichi Ishiura; Nobuhisa Iwata; Takaomi C Saido; Sosuke Yagishita; Kei Maruyama
An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(10):3720-30.
2011: Takashi Saito; Kristel Sleegers; Takahiro Suemoto; Jiro Takano; Christine Van Broeckhoven; Kazuyuki Yamada; Nathalie Brouwers; Satoru Funamoto; Yasuo Ihara; Nobuhisa Iwata; Yukio Matsuba; Naomi Mihira; Per Nilsson; Masaki Nishimura; Takaomi C Saido
Potent amyloidogenicity and pathogenicity of Aβ43.
Nature neuroscience 2011;14(8):1023-32.
2011: Ko Sato; Seiji Minegishi; Jiro Takano; Florian Plattner; Taro Saito; Akiko Asada; Hiroyuki Kawahara; Nobuhisa Iwata; Takaomi C Saido; Shin-ichi Hisanaga
Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.
Journal of neurochemistry 2011;117(3):504-15.
2011: Jun Maeda; Ming-Rong Zhang; Takashi Okauchi; Bin Ji; Maiko Ono; Satoko Hattori; Katsushi Kumata; Nobuhisa Iwata; Takaomi C Saido; John Q Trojanowski; Virginia M-Y Lee; Matthias Staufenbiel; Takami Tomiyama; Hiroshi Mori; Toshimitsu Fukumura; Tetsuya Suhara; Makoto Higuchi
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(12):4720-30.
2011: João R Gomes; Andrea C Lobo; Carlos V Melo; Ana R Inácio; Jiro Takano; Nobuhisa Iwata; Takaomi C Saido; Luis de Almeida; Tadeusz Wieloch; Carlos B Duarte
Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(12):4622-35.
2011: Naoki Yahata; Shinya Yamanaka; Takashi Asada; Masashi Asai; Isao Asaka; Hiroyuki Hioki; Nobuhisa Iwata; Takeshi Kaneko; Shiho Kitaoka; Kei Maruyama; Tatsutoshi Nakahata; Takaomi C Saido; Kazutoshi Takahashi; Haruhisa Inoue
Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease.
PloS one 2011;6(9):e25788.
2011: Guoqiang Zhang; Alison L Thomas; Amanda L Marshall; Kelly A Kernan; Yanyuan Su; Yi Zheng; Jiro Takano; Takaomi C Saido; Allison A Eddy
Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy.
Laboratory investigation; a journal of technical methods and pathology 2011;91(1):106-23.
2010: Johannes Attems; Haruyasu Yamaguchi; Takaomi C Saido; Dietmar Rudolf Thal
Capillary CAA and perivascular Aβ-deposition: two distinct features of Alzheimer's disease pathology.
Journal of the neurological sciences 2010;299(1-2):155-62.
2010: Masashi Asai; Nobuhisa Iwata; Taisuke Tomita; Takeshi Iwatsubo; Shoichi Ishiura; Takaomi C Saido; Kei Maruyama
Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease.
Journal of neuroscience research 2010;88(16):3588-97.
2010: Dietmar R Thal; Andreas Papassotiropoulos; Takaomi C Saido; W Sue T Griffin; Robert E Mrak; Heike Kölsch; Kelly Del Tredici; Johannes Attems; Estifanos Ghebremedhin
Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease.
Acta neuropathologica 2010;120(2):169-83.
2010: Per Nilsson; Nobuhisa Iwata; Shin-ichi Muramatsu; Lars O Tjernberg; Bengt Winblad; Takaomi C Saido
Gene therapy in Alzheimer's disease - potential for disease modification.
Journal of cellular and molecular medicine 2010;14(4):741-57.
2009: Yoichiro Nishida; Shingo Ito; Sumio Ohtsuki; Naoki Yamamoto; Tsubura Takahashi; Nobuhisa Iwata; Kou-ichi Jishage; Hiromi Yamada; Hiroki Sasaguri; Shigefumi Yokota; Wenying Piao; Hiroyuki Tomimitsu; Takaomi C Saido; Katsuhiko Yanagisawa; Tetsuya Terasaki; Hidehiro Mizusawa; Takanori Yokota
Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease.
The Journal of biological chemistry 2009;284(48):33400-8.
2009: Yun-Sik Choi; Boyoung Lee; Hee-Yeon Cho; Iza B Reyes; Xin-An Pu; Takaomi C Saido; K Hoyt; Karl Obrietan
CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease.
Neurobiology of disease 2009;36(2):259-68.
2009: Hironori Fujiwara; Masahiro Tabuchi; Takuji Yamaguchi; Koh Iwasaki; Katsutoshi Furukawa; Kyoji Sekiguchi; Yasushi Ikarashi; Yukitsuka Kudo; Makoto Higuchi; Takaomi C Saido; Sumihiro Maeda; Akihiko Takashima; Masahiko Hara; Nobuo Yaegashi; Yoshio Kase; Hiroyuki Arai
A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo.
Journal of neurochemistry 2009;109(6):1648-57.
2009: Toru Nakazawa; Masahiko Shimura; Ryu Mourin; Mineo Kondo; Shunji Yokokura; Takaomi C Saido; Kohji Nishida; Shogo Endo
Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells.
Journal of neuroscience research 2009;87(6):1412-23.
2009: Toshimitsu Suzuki; Hiroyuki Miyamoto; Takashi Nakahari; Ikuyo Inoue; Takahiro Suemoto; Bin Jiang; Yuki Hirota; Shigeyoshi Itohara; Takaomi C Saido; Tadaharu Tsumoto; Kazunobu Sawamoto; Takao K Hensch; Antonio V Delgado-Escueta; Kazuhiro Yamakawa
Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility.
Human molecular genetics 2009;18(6):1099-109.
2009: Atsuhiro Adachi; Fumi Kano; Takaomi C Saido; Masayuki Murata
Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(3):355-69.
2009: Hideko Kokubo; Rakez Kayed; Charles G Glabe; Matthias Staufenbiel; Takaomi C Saido; Nobuhisa Iwata; Haruyasu Yamaguchi
Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification.
International journal of Alzheimer's disease 2009;2009():.
2009: Isabel Gonçalves; Mihaela Nitulescu; Takaomi C Saido; Nuno Dias; Luís M Pedro; José Fernandes E Fernandes; Mikko P S Ares; Isabella Pörn-Ares
Activation of calpain-1 in human carotid artery atherosclerotic lesions.
BMC cardiovascular disorders 2009;9():26.
2008: Holger Cynis; Eike Scheel; Takaomi C Saido; Stephan Schilling; Hans-Ulrich Demuth
Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.
Biochemistry 2008;47(28):7405-13.
2008: Kulandaivelu S Vetrivel; Xulun Zhang; Xavier Meckler; Haipeng Cheng; Sungho Lee; Ping Gong; Kryslaine O Lopes; Ying Chen; Nobuhisa Iwata; Ke-Jie Yin; Jin-Moo Lee; Angèle T Parent; Takaomi C Saido; Yueming Li; Sangram S Sisodia; Gopal Thinakaran
Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta.
The Journal of biological chemistry 2008;283(28):19489-98.
2008: Jiying Wang; Kyoko Ohno-Matsui; Takeshi Yoshida; Ariko Kojima; Noriaki Shimada; Ken-ichi Nakahama; Olga Safranova; Nobuhisa Iwata; Takaomi C Saido; Manabu Mochizuki; Ikuo Morita
Altered function of factor I caused by amyloid beta: implication for pathogenesis of age-related macular degeneration from Drusen.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):712-20.
2008: Chiho Hirata-Fukae; Hui-Fang Li; Hyang-Sook Hoe; Audrey J Gray; S Sakura Minami; Katsuyoshi Hamada; Takako Niikura; Fang Hua; Hiroe Tsukagoshi-Nagai; Yuko Horikoshi-Sakuraba; Mohamed Mughal; G. William Rebeck; Frank M LaFerla; Mark P Mattson; Nobuhisa Iwata; Takaomi C Saido; William L Klein; karen duff; Paul S Aisen; Yasuji Matsuoka
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.
Brain research 2008;1216():92-103.
2008: Nobuhisa Iwata; Makoto Higuchi; Takaomi C Saido
[Therapeutic strategy by manipulating some protease activities for Alzheimer's disease].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2008;131(5):320-5.
2008: Yuriko Tachida; Kazuhiro Nakagawa; Takashi Saito; Takaomi C Saido; Takashi Honda; Yuko Saito; Shigeo Murayama; Tamao Endo; Gaku Sakaguchi; Akira Kato; Shinobu Kitazume; Yasuhiro Hashimoto
Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production.
Journal of neurochemistry 2008;104(5):1387-93.
2008: Ryuichi Nakajima; Keizo Takao; Shu-Ming Huang; Jiro Takano; Nobuhisa Iwata; Tsuyoshi Miyakawa; Takaomi C Saido
Comprehensive behavioral phenotyping of calpastatin-knockout mice.
Molecular brain 2008;1():7.
2007: Oliver Wirths; Joachim Weis; Rakez Kayed; Takaomi C Saido; Thomas A Bayer
Age-dependent axonal degeneration in an Alzheimer mouse model.
Neurobiology of aging 2007;28(11):1689-99.
2007: Jun Maeda; Bin Ji; Toshiaki Irie; Takami Tomiyama; Masahiro Maruyama; Takashi Okauchi; Matthias Staufenbiel; Nobuhisa Iwata; Maiko Ono; Takaomi C Saido; Kazutoshi Suzuki; Hiroshi Mori; Makoto Higuchi; Tetsuya Suhara
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(41):10957-68.
2007: Jing Wang; Bernadette Pignol; Pierre-Etienne Chabrier; Takaomi C Saido; Ruth Lloyd; Yong Tang; Marc Lenoir; Jean-Luc Puel
A novel dual inhibitor of calpains and lipid peroxidation (BN82270) rescues the cochlea from sound trauma.
Neuropharmacology 2007;52(6):1426-37.
2007: Yukiko Hori; Tadafumi Hashimoto; Yosuke Wakutani; Katsuya Urakami; Kenji Nakashima; Margaret M Condron; Satoshi Tsubuki; Takaomi C Saido; David B Teplow; Takeshi Iwatsubo
The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation.
The Journal of biological chemistry 2007;282(7):4916-23.
2007: Yasumasa Yoshiyama; Makoto Higuchi; Bin Zhang; Shu-Ming Huang; Nobuhisa Iwata; Takaomi C Saido; Jun Maeda; Tetsuya Suhara; John Q Trojanowski; Virginia M-Y Lee
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model.
Neuron 2007;53(3):337-51.
2007: Hirotsugu Kamei; Taro Saito; Mirai Ozawa; Yuichi Fujita; Akiko Asada; James A Bibb; Takaomi C Saido; Hiroyuki Sorimachi; Shin-ichi Hisanaga
Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation.
The Journal of biological chemistry 2007;282(3):1687-94.
2007: Masashi Asai; Nobuhisa Iwata; Ayumu Yoshikawa; Yoshimi Aizaki; Shoichi Ishiura; Takaomi C Saido; Kei Maruyama
Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion.
Biochemical and biophysical research communications 2007;352(2):498-502.
2006: Runa Araya; Takanori Noguchi; Munehiro Yuhki; Naohito Kitamura; Makoto Higuchi; Takaomi C Saido; Kenjiro Seki; Shigeyoshi Itohara; Masako Kawano; Kentaro Tanemura; Akihiko Takashima; Kazuyuki Yamada; Yasushi Kondoh; Iwao Kanno; Jürgen Wess; Masahisa Yamada
Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.
Neurobiology of disease 2006;24(2):334-44.
2006: Makoto Higuchi; Takaomi C Saido; Tetsuya Suhara
Animal models of tauopathies.
Neuropathology : official journal of the Japanese Society of Neuropathology 2006;26(5):491-7.
2006: Holger Cynis; Stephan Schilling; Mandy Bodnár; Torsten Hoffmann; Ulrich Heiser; Takaomi C Saido; Hans-Ulrich Demuth
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.
Biochimica et biophysica acta 2006;1764(10):1618-25.
2006: Chinatsu Hattori; Masashi Asai; Hayato Onishi; Noboru Sasagawa; Yasuhiro Hashimoto; Takaomi C Saido; Kei Maruyama; Shigehiko Mizutani; Shoichi Ishiura
BACE1 interacts with lipid raft proteins.
Journal of neuroscience research 2006;84(4):912-7.
2006: Hironori Fujiwara; Koh Iwasaki; Katsutoshi Furukawa; Takashi Seki; Mei He; Masahiro Maruyama; Naoki Tomita; Yukitsuka Kudo; Makoto Higuchi; Takaomi C Saido; Sumihiro Maeda; Akihiko Takashima; Masahiko Hara; Yasushi Ohizumi; Hiroyuki Arai
Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins.
Journal of neuroscience research 2006;84(2):427-33.
2006: Toru Sato; Andrew C Nyborg; Nobuhisa Iwata; Thekla S Diehl; Takaomi C Saido; todd golde; Michael S Wolfe
Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs.
Biochemistry 2006;45(28):8649-56.
2006: Shu-Ming Huang; Akihiro Mouri; Hideko Kokubo; Ryuichi Nakajima; Takahiro Suemoto; Makoto Higuchi; Matthias Staufenbiel; Yukihiro Noda; Haruyasu Yamaguchi; Toshitaka Nabeshima; Takaomi C Saido; Nobuhisa Iwata
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.
The Journal of biological chemistry 2006;281(26):17941-51.
2006: Eriko Samura; Mikio Shoji; Takeshi Kawarabayashi; Atsushi Sasaki; Etsuro Matsubara; Tetsuro Murakami; Xu Wuhua; Shuta Tamura; Masaki Ikeda; Koich Ishiguro; Takaomi C Saido; David Westaway; Peter St George-Hyslop; Yasuo Harigaya; Koji Abe
Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1.
Brain research 2006;1094(1):192-9.
2006: Takaomi C Saido; Nobuhisa Iwata
Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy.
Neuroscience research 2006;54(4):235-53.
2006: Li-Bo Zou; Akihiro Mouri; Nobuhisa Iwata; Takaomi C Saido; Dayong Wang; Min-Wei Wang; Hiroyuki Mizoguchi; Yukihiro Noda; Toshitaka Nabeshima
Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory.
The Journal of pharmacology and experimental therapeutics 2006;317(1):334-40.
2006: Akihiro Mouri; Li-Bo Zou; Nobuhisa Iwata; Takaomi C Saido; Dayong Wang; Min-Wei Wang; Yukihiro Noda; Toshitaka Nabeshima
Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory.
Behavioural brain research 2006;168(1):83-91.
2006: Yasuo Harigaya; Yasushi Tomidokoro; Masaki Ikeda; Atsushi Sasaki; Takeshi Kawarabayashi; Etsuro Matsubara; Mitsuyasu Kanai; Takaomi C Saido; Steven G Younkin; Mikio Shoji
Type-specific evolution of amyloid plaque and angiopathy in APPsw mice.
Neuroscience letters 2006;395(1):37-41.
2006: Kazuhiro Nakagawa; Shinobu Kitazume; Ritsuko Oka; Kei Maruyama; Takaomi C Saido; Yuji Sato; Tamao Endo; Yasuhiro Hashimoto
Sialylation enhances the secretion of neurotoxic amyloid-beta peptides.
Journal of neurochemistry 2006;96(4):924-33.
2006: Masashi Asai; Chinatsu Hattori; Nobuhisa Iwata; Takaomi C Saido; Noboru Sasagawa; Beáta Szabó; Yasuhiro Hashimoto; Kei Maruyama; Sei-ichi Tanuma; Yoshiaki Kiso; Shoichi Ishiura
The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
Journal of neurochemistry 2006;96(2):533-40.
2005: Nobuhisa Iwata; Takaomi C Saido; Hiroaki Mizukami; Keiya Ozawa
[Experimental gene therapy for Alzheimer's disease--animal models].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():691-8.
2005: Tokiko Ogawa; Sumiko Kiryu-Seo; Masaaki Tanaka; Hiroyuki Konishi; Nobuhisa Iwata; Takaomi C Saido; Yasuyoshi Watanabe; Hiroshi Kiyama
Altered expression of neprilysin family members in the pituitary gland of sleep-disturbed rats, an animal model of severe fatigue.
Journal of neurochemistry 2005;95(4):1156-66.
2005: Dietmar R Thal; Estibaliz Capetillo-Zarate; Christian Schultz; Udo Rüb; Takaomi C Saido; Haruyasu Yamaguchi; Christian Haass; W Sue T Griffin; Kelly Del Tredici; Heiko Braak; Estifanos Ghebremedhin
Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner.
Acta neuropathologica 2005;110(5):459-71.
2005: Nobuhisa Iwata; Makoto Higuchi; Takaomi C Saido
Metabolism of amyloid-beta peptide and Alzheimer's disease.
Pharmacology & therapeutics 2005;108(2):129-48.
2005: Alessandra Piccini; Claudio Russo; Alessandra Gliozzi; Annalisa Relini; Antonella Vitali; Roberta Borghi; Luca Giliberto; Andrea Armirotti; Cristina D'Arrigo; Angela Bachi; Angela Cattaneo; Claudio Canale; Silvia Torrassa; Takaomi C Saido; William R Markesbery; Pierluigi Gambetti; Massimo Tabaton
beta-amyloid is different in normal aging and in Alzheimer disease.
The Journal of biological chemistry 2005;280(40):34186-92.
2005: Nobuhisa Iwata; Makoto Higuchi; Takashi Saito; Takaomi C Saido
[Presymptomatic diagnosis, prevention and therapy].
Nō to shinkei = Brain and nerve 2005;57(10):855-66.
2005: Takeshi Yoshida; Kyoko Ohno-Matsui; Shizuko Ichinose; Tetsuji Sato; Nobuhisa Iwata; Takaomi C Saido; Toshio Hisatomi; Manabu Mochizuki; Ikuo Morita
The potential role of amyloid beta in the pathogenesis of age-related macular degeneration.
The Journal of clinical investigation 2005;115(10):2793-800.
2005: Makoto Higuchi; Nobuhisa Iwata; Takaomi C Saido
Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions.
Biochimica et biophysica acta 2005;1751(1):60-7.
2005: Masahiro Maruyama; Makoto Higuchi; Yoshie Takaki; Yukio Matsuba; Haruko Tanji; Miyako Nemoto; Naoki Tomita; Toshifumi Matsui; Nobuhisa Iwata; Hiroaki Mizukami; Shin-ichi Muramatsu; Keiya Ozawa; Takaomi C Saido; Hiroyuki Arai; Hidetada Sasaki
Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease.
Annals of neurology 2005;57(6):832-42.
2005: Hideko Kokubo; Rakez Kayed; Charles G Glabe; Takaomi C Saido; Nobuhisa Iwata; J Bernd Helms; Haruyasu Yamaguchi
Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain.
Brain research 2005;1045(1-2):224-8.
2005: Toru Sato; Yu Tanimura; Naoko Hirotani; Takaomi C Saido; Maho Morishima-Kawashima; Yasuo Ihara
Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.
FEBS letters 2005;579(13):2907-12.
2005: Jiro Takano; Masanori Tomioka; Satoshi Tsubuki; Makoto Higuchi; Nobuhisa Iwata; Shigeyoshi Itohara; Masatoshi Maki; Takaomi C Saido
Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.
The Journal of biological chemistry 2005;280(16):16175-84.
2005: Makoto Higuchi; Masanori Tomioka; Jiro Takano; Keiro Shirotani; Nobuhisa Iwata; Hajime Masumoto; Masatoshi Maki; Shigeyoshi Itohara; Takaomi C Saido
Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.
The Journal of biological chemistry 2005;280(15):15229-37.
2005: Atsushi Kambe; Masayuki Yokota; Takaomi C Saido; Ichiro Satokata; Hirokazu Fujikawa; Sadaharu Tabuchi; Hideki Kamitani; Takashi Watanabe
Spatial resolution of calpain-catalyzed proteolysis in focal cerebral ischemia.
Brain research 2005;1040(1-2):36-43.
2005: Takashi Saito; Nobuhisa Iwata; Satoshi Tsubuki; Yoshie Takaki; Jiro Takano; Shu-Ming Huang; Takahiro Suemoto; Makoto Higuchi; Takaomi C Saido
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.
Nature medicine 2005;11(4):434-9.
2005: Makoto Higuchi; Nobuhisa Iwata; Yukio Matsuba; Kumi Sato; Kazumi Sasamoto; Takaomi C Saido
19F and 1H MRI detection of amyloid beta plaques in vivo.
Nature neuroscience 2005;8(4):527-33.
2005: Hideko Kokubo; Takaomi C Saido; Nobuhisa Iwata; J Bernd Helms; Rumi Shinohara; Haruyasu Yamaguchi
Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain.
Neurobiology of aging 2005;26(4):409-18.
2005: Ryong-Woon Shin; Takaomi C Saido; Masahiro Maeda; Tetsuyuki Kitamoto
Novel alpha-secretase cleavage of Alzheimer's amyloid beta precursor protein in the endoplasmic reticulum of COS7 cells.
Neuroscience letters 2005;376(1):14-9.
2005: Masami Hayashi; Yasuko Koshihara; Hideaki Ishibashi; Seizo Yamamoto; Satoshi Tsubuki; Takaomi C Saido; Seiichi Kawashima; Mitsushi Inomata
Involvement of calpain in osteoclastic bone resorption.
Journal of biochemistry 2005;137(3):331-8.
2005: Katarzyna Bialkowska; Takaomi C Saido; Joan E B Fox
SH3 domain of spectrin participates in the activation of Rac in specialized calpain-induced integrin signaling complexes.
Journal of cell science 2005;118(Pt 2):381-95.
2005: Yue Qi-Takahara; Maho Morishima-Kawashima; Yu Tanimura; Georgia Dolios; Naoko Hirotani; Yuko Horikoshi; Fuyuki Kametani; Masahiro Maeda; Takaomi C Saido; Rong Wang; Yasuo Ihara
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(2):436-45.
2005: Emi Hama; Takaomi C Saido
Etiology of sporadic Alzheimer's disease: somatostatin, neprilysin, and amyloid beta peptide.
Medical hypotheses 2005;65(3):498-500.
2004: Takaomi C Saido
[Towards presymptomatic diagnosis, prevention and treatment of Alzheimer's disease].
Rinshō shinkeigaku = Clinical neurology 2004;44(11):775-7.
2004: Shinobu Kitazume; Norihiro Kotani; Hiroshi Nakato; Takaomi C Saido; Yasuhiro Hashimoto
[Glycosyltransferases as substrates for Alzheimer's beta-secretase].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2004;49(15 Suppl):2468-72.
2004: Satoru Funamoto; Maho Morishima-Kawashima; Yu Tanimura; Naoko Hirotani; Takaomi C Saido; Yasuo Ihara
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.
Biochemistry 2004;43(42):13532-40.
2004: Sabine Ladrech; Matthieu J Guitton; Takaomi C Saido; Marc Lenoir
Calpain activity in the amikacin-damaged rat cochlea.
The Journal of comparative neurology 2004;477(2):149-60.
2004: Emi Hama; Keiro Shirotani; Nobuhisa Iwata; Takaomi C Saido
Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons.
The Journal of biological chemistry 2004;279(29):30259-64.
2004: Kumi Sato; Makoto Higuchi; Nobuhisa Iwata; Takaomi C Saido; Kazumi Sasamoto
Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques.
European journal of medicinal chemistry 2004;39(7):573-8.
2004: Yosuke Wakutani; K Watanabe; Yoshiki Adachi; Kenji Wada-Isoe; Katsuya Urakami; H Ninomiya; Takaomi C Saido; T Hashimoto; Takeshi Iwatsubo; Kenji Nakashima
Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2004;75(7):1039-42.
2004: Tooru Kimura; Daisuke Shuto; Soko Kasai; Ping Liu; Koushi Hidaka; Takashi Hamada; Yoshio Hayashi; Chinatsu Hattori; Masashi Asai; Shinobu Kitazume; Takaomi C Saido; Shoichi Ishiura; Yoshiaki Kiso
KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine.
Bioorganic & medicinal chemistry letters 2004;14(6):1527-31.
2004: Nobuhisa Iwata; Hiroaki Mizukami; Keiro Shirotani; Yoshie Takaki; Shin-ichi Muramatsu; Bao Lu; Norma P Gerard; Craig Gerard; Keiya Ozawa; Takaomi C Saido
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(4):991-8.
2004: Shinobu Kitazume; Minoru Suzuki; Takaomi C Saido; Yasuhiro Hashimoto
Involvement of proteases in glycosyltransferase secretion: Alzheimer's beta-secretase-dependent cleavage and a following processing by an aminopeptidase.
Glycoconjugate journal 2004;21(1-2):25-9.
2004: Shinobu Kitazume; Takaomi C Saido; Yasuhiro Hashimoto
Alzheimer's beta-secretase cleaves a glycosyltransferase as a physiological substrate.
Glycoconjugate journal 2004;20(1):59-62.
2003: Haruhisa Inoue; Kayoko Tsukita; Takuji Iwasato; Yasuyuki Suzuki; Masanori Tomioka; Minako Tateno; Masahiro Nagao; Akihiro Kawata; Takaomi C Saido; Masayuki Miura; Hidemi Misawa; Shigeyoshi Itohara; Ryosuke Takahashi
The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model.
The EMBO journal 2003;22(24):6665-74.
2003: Abdelhaq Rami; T Volkmann; R Agarwal; S Schoninger; F Nürnberger; Takaomi C Saido; J Winckler
beta2-Adrenergic receptor responsiveness of the calpain-calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia.
Neuroscience research 2003;47(4):373-82.
2003: Dengshun Wang; Nobuhisa Iwata; Emi Hama; Takaomi C Saido; dennis dickson
Oxidized neprilysin in aging and Alzheimer's disease brains.
Biochemical and biophysical research communications 2003;310(1):236-41.
2003: Masayuki Yokota; Takaomi C Saido; Hideki Kamitani; Sadaharu Tabuchi; Ichiro Satokata; Takashi Watanabe
Calpain induces proteolysis of neuronal cytoskeleton in ischemic gerbil forebrain.
Brain research 2003;984(1-2):122-32.
2003: M Isabella Pörn-Ares; Takaomi C Saido; Tommy Andersson; Mikko P S Ares
Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells.
The Biochemical journal 2003;374(Pt 2):403-11.
2003: Nobuhisa Iwata; Takaomi C Saido
[Amyloid-beta peptide metabolism and Alzheimer's disease].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(1):5-14.
2003: Satoshi Tsubuki; Yoshie Takaki; Takaomi C Saido
Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation.
Lancet 2003;361(9373):1957-8.
2003: Shinobu Kitazume-Kawaguchi; Yasuhiro Hashimoto; Takaomi C Saido
[BACE1 and glycosyltransferases].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2003;48(8 Suppl):984-9.
2003: Shinobu Kitazume; Yuriko Tachida; Ritsuko Oka; Norihiro Kotani; Kazuko Ogawa; Minoru Suzuki; Naoshi Dohmae; Koji Takio; Takaomi C Saido; Yasuhiro Hashimoto
Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).
The Journal of biological chemistry 2003;278(17):14865-71.
2003: Jian Zhang; Ken-ichiro Miyamoto; Sadayuki Hashioka; Hai Peng Hao; Koji Murao; Takaomi C Saido; Hiroshi Nakanishi
Activation of mu-calpain in developing cortical neurons following methylmercury treatment.
Brain research. Developmental brain research 2003;142(1):105-10.
2003: Takashi Saito; Yoshie Takaki; Nobuhisa Iwata; John Q Trojanowski; Takaomi C Saido
Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism.
Science of aging knowledge environment : SAGE KE 2003;2003(3):PE1.
2003: Tetsumori Yamashima; Anton B Tonchev; Toshiyuki Tsukada; Takaomi C Saido; Shinobu Imajoh-Ohmi; Takashi Momoi; Eiki Kominami
Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates.
Hippocampus 2003;13(7):791-800.
2002: Masanori Tomioka; Keiro Shirotani; Nobuhisa Iwata; Hahn-Jun Lee; Fusheng Yang; Gregory M. Cole; Yousuke Seyama; Takaomi C Saido
In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons.
Brain research. Molecular brain research 2002;108(1-2):18-32.
2002: Ken-ichiro Kuwako; Isao Nishimura; Taichi Uetsuki; Takaomi C Saido; Kazuaki Yoshikawa
Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein.
Brain research. Molecular brain research 2002;107(2):166-75.
2002: Nobuhisa Iwata; Yoshie Takaki; Shinjiro Fukami; Satoshi Tsubuki; Takaomi C Saido
Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.
Journal of neuroscience research 2002;70(3):493-500.
2002: Shinobu Kitazume; Takaomi C Saido; Yasuhiro Hashimoto
[Identification of a novel substrate of Alzheimer's beta-secretase: beta-secretase dependent cleavage of alpha 2,6 sialyltransferase].
Seikagaku. The Journal of Japanese Biochemical Society 2002;74(9):1180-3.
2002: Megumi Takahashi; Shinjiro Fukami; Nobuhisa Iwata; Keiichi Inoue; Shigeyoshi Itohara; Hiroshi Itoh; Jo Haraoka; Takaomi C Saido
In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture.
Pharmacological research : the official journal of the Italian Pharmacological Society 2002;46(2):155-63.
2002: Keiro Shirotani; Satoshi Tsubuki; Hahn-Jun Lee; Kei Maruyama; Takaomi C Saido
Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons.
Neuroscience letters 2002;327(1):25-8.
2002: Chinatsu Hattori; Masashi Asai; Yoko Oma; Yoshihiro Kino; Noboru Sasagawa; Takaomi C Saido; Kei Maruyama; Shoichi Ishiura
BACE1 interacts with nicastrin.
Biochemical and biophysical research communications 2002;293(4):1228-32.
2002: Shinjiro Fukami; Kaori Watanabe; Nobuhisa Iwata; Jo Haraoka; Bao Lu; Norma P Gerard; Craig Gerard; Paul E Fraser; David Westaway; Peter St George-Hyslop; Takaomi C Saido
Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.
Neuroscience research 2002;43(1):39-56.
2002: Elisabetta Daré; Roshan Tofighi; Maria Vittoria Vettori; Takashi Momoi; Diana Poli; Takaomi C Saido; Antonio Mutti; Sandra Ceccatelli
Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells.
Brain research 2002;933(1):12-22.
2001: JE Kim; Baek S Han; Won-Seok Choi; Dae-Seok Eom; E H Lee; Tae H Oh; George J Markelonis; Takaomi C Saido; Gun Eui Lee; In Kwon Chung; Young J Oh
Temporospatial sequence of cellular events associated with etoposide-induced neuronal cell death: role of antiapoptotic protein Bcl-X(L).
Journal of neuroscience research 2001;66(6):1074-82.
2001: Emi Hama; Keiro Shirotani; Hajime Masumoto; Y Sekine-Aizawa; H Aizawa; Takaomi C Saido
Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons.
Journal of biochemistry 2001;130(6):721-6.
2001: Shinobu Kitazume; Yuriko Tachida; Ritsuko Oka; K Shirotani; Takaomi C Saido; Yasuhiro Hashimoto
Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13554-9.
2001: T Kaneko; Tetsumori Yamashima; Yasuo Tohma; M Nomura; Shinobu Imajoh-Ohmi; Takaomi C Saido; M Nakao; H Saya; Hiroshi Yamamoto; Junkoh Yamashita
Calpain-dependent proteolysis of merlin occurs by oxidative stress in meningiomas: a novel hypothesis of tumorigenesis.
Cancer 2001;92(10):2662-72.
2001: M Morishima-Kawashima; Takaomi C Saido; Yasuo Ihara
[Alzheimer's disease and the proteins].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2001;46(11 Suppl):1798-804.
2001: Keiro Shirotani; Satoshi Tsubuki; Nobuhisa Iwata; Yoshie Takaki; W Harigaya; K Maruyama; S Kiryu-Seo; H Kiyama; H Iwata; Taisuke Tomita; Takeshi Iwatsubo; Takaomi C Saido
Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.
The Journal of biological chemistry 2001;276(24):21895-901.
2001: Won-Seok Choi; E H Lee; C W Chung; Yong-Keun Jung; BK Jin; S U Kim; Tae H Oh; Takaomi C Saido; Young J Oh
Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2.
Journal of neurochemistry 2001;77(6):1531-41.
2001: Nobuhisa Iwata; Satoshi Tsubuki; Yoshie Takaki; Keiro Shirotani; Bao Lu; Norma P Gerard; Craig Gerard; Emi Hama; Hahn-Jun Lee; Takaomi C Saido
Metabolic regulation of brain Abeta by neprilysin.
Science (New York, N.Y.) 2001;292(5521):1550-2.
2001: Y Sekine-Aizawa; Emi Hama; Kaori Watanabe; Satoshi Tsubuki; M Kanai-Azuma; Y Kanai; Hiroyuki Arai; H Aizawa; Nobuhisa Iwata; Takaomi C Saido
Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellum.
The European journal of neuroscience 2001;13(5):935-48.
2001: S Taniguchi; Y Fujita; S Hayashi; A Kakita; Hidenori Takahashi; S Murayama; Takaomi C Saido; S Hisanaga; Takeshi Iwatsubo; M Hasegawa
Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.
FEBS letters 2001;489(1):46-50.
2001: Takeshi Kawarabayashi; Linda Younkin; Takaomi C Saido; Mikio Shoji; Karen K. Hsiao Ashe; Steven G Younkin
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(2):372-81.
2000: Yoshie Takaki; Nobuhisa Iwata; Satoshi Tsubuki; S Taniguchi; S Toyoshima; Bao Lu; Norma P Gerard; Craig Gerard; Hahn-Jun Lee; Keiro Shirotani; Takaomi C Saido
Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain.
Journal of biochemistry 2000;128(6):897-902.
2000: Katarzyna Bialkowska; Sucheta Kulkarni; Xiaoping Du; Darrel E Goll; Takaomi C Saido; Joan E B Fox
Evidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become active.
The Journal of cell biology 2000;151(3):685-96.
2000: Y Harigaya; Takaomi C Saido; Christopher B Eckman; CM Prada; Mikio Shoji; Steven G Younkin
Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain.
Biochemical and biophysical research communications 2000;276(2):422-7.
2000: Hahn-Jun Lee; Masanori Tomioka; Y Takaki; Hajime Masumoto; Takaomi C Saido
Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus.
Biochimica et biophysica acta 2000;1493(1-2):273-8.
2000: Hisashi Koike; Z Kouchi; T Kinouchi; T Maeda; Hiroyuki Sorimachi; Takaomi C Saido; Kei Maruyama; A Okuyama; Kazutoshi Suzuki; Shoichi Ishiura
Metabolism of amyloid precursor protein in COS cells transfected with a beta-secretase candidate.
Cytotechnology 2000;33(1-3):213-9.
2000: A Takeuchi; Michael C Irizarry; karen duff; Takaomi C Saido; Karen K. Hsiao Ashe; M Hasegawa; D M A Mann; Bradley T Hyman; Takeshi Iwatsubo
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.
The American journal of pathology 2000;157(1):331-9.
2000: S Lankiewicz; C Marc Luetjens; N Truc Bui; AJ Krohn; Monika Poppe; Gregory M. Cole; Takaomi C Saido; Jochen H M Prehn
Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death.
The Journal of biological chemistry 2000;275(22):17064-71.
2000: Claudio Russo; Gennaro Schettini; Takaomi C Saido; Christine M Hulette; Carol F Lippa; Lars Lannfelt; Bernardino Ghetti; Pierluigi Gambetti; Massimo Tabaton; JK Teller
Presenilin-1 mutations in Alzheimer's disease.
Nature 2000;405(6786):531-2.
2000: Y Nakagawa; L Reed; M Nakamura; Tracy K McIntosh; Douglas H Smith; Kathryn E Saatman; Ramesh Raghupathi; J Clemens; Takaomi C Saido; Virginia M-Y Lee; John Q Trojanowski
Brain trauma in aged transgenic mice induces regression of established abeta deposits.
Experimental neurology 2000;163(1):244-52.
2000: Mikio Shoji; Takeshi Kawarabayashi; M Sato; A Sasaki; Takaomi C Saido; Etsuro Matsubara; Yasushi Tomidokoro; Mitsuyasu Kanai; M Shizuka; Koichi Ishiguro; Masaki Ikeda; Yasuo Harigaya; Koichi Okamoto; Shunsaku Hirai
Age-related amyloid beta protein accumulation induces cellular death and macrophage activation in transgenic mice.
The Journal of pathology 2000;191(1):93-101.
2000: H Kitagaki; S Tomioka; T Yoshizawa; Hiroyuki Sorimachi; Takaomi C Saido; Shoichi Ishiura; Kazutoshi Suzuki
Autolysis of calpain large subunit inducing irreversible dissociation of stoichiometric heterodimer of calpain.
Bioscience, biotechnology, and biochemistry 2000;64(4):689-95.
2000: Takaomi C Saido
Involvement of polyglutamine endolysis followed by pyroglutamate formation in the pathogenesis of triplet repeat/polyglutamine-expansion diseases.
Medical hypotheses 2000;54(3):427-9.
2000: K Maruyama; Mihoko Usami; Fuyuki Kametani; Taisuke Tomita; Takeshi Iwatsubo; Takaomi C Saido; Hiroshi Mori; S Ishiura
Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain.
International journal of molecular medicine 2000;5(3):269-73.
2000: Nobuhisa Iwata; Satoshi Tsubuki; Yoshie Takaki; Kaori Watanabe; M Sekiguchi; E Hosoki; M Kawashima-Morishima; Hahn-Jun Lee; Emi Hama; Y Sekine-Aizawa; Takaomi C Saido
Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition.
Nature medicine 2000;6(2):143-50.
1999: Taisuke Tomita; Rie Takikawa; A Koyama; Yuichi Morohashi; Nobumasa Takasugi; Takaomi C Saido; Kei Maruyama; Takeshi Iwatsubo
C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(24):10627-34.
1999: M Luise Schmidt; Takaomi C Saido; Virginia M-Y Lee; John Q Trojanowski
Spatial relationship of AMY protein deposits and different species of Abeta peptides in amyloid plaques of the Alzheimer disease brain.
Journal of neuropathology and experimental neurology 1999;58(12):1227-33.
1999: Masami Hayashi; H Suzuki; Seiichi Kawashima; Takaomi C Saido; Mitsushi Inomata
The behavior of calpain-generated N- and C-terminal fragments of talin in integrin-mediated signaling pathways.
Archives of biochemistry and biophysics 1999;371(2):133-41.
1999: Hisashi Koike; Sachiko Tomioka; Hiroyuki Sorimachi; Takaomi C Saido; Kei Maruyama; A Okuyama; A Fujisawa-Sehara; Shigeaki Ohno; Kazutoshi Suzuki; Shoichi Ishiura
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein.
The Biochemical journal 1999;343 Pt 2():371-5.
1999: H Fukumoto; Taisuke Tomita; H Matsunaga; Y Ishibashi; Takaomi C Saido; Takeshi Iwatsubo
Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid beta peptides ending at A beta40 and A beta42.
Neuroreport 1999;10(14):2965-9.
1999: DC Shields; Kurt Schaecher; Takaomi C Saido; Narendra L. Banik
A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11486-91.
1999: Y Nakagawa; M Nakamura; Tracy K McIntosh; Aurelio Rodriguez; J A Berlin; Douglas H Smith; Kathryn E Saatman; Ramesh Raghupathi; J Clemens; Takaomi C Saido; M Luise Schmidt; Virginia M-Y Lee; John Q Trojanowski
Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging.
The Journal of comparative neurology 1999;411(3):390-8.
1999: Eileen McGowan; S Sanders; Takeshi Iwatsubo; A Takeuchi; Takaomi C Saido; Cynthia Zehr; X Yu; Sacha N Uljon; Rong Wang; D M A Mann; dennis dickson; karen duff
Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes.
Neurobiology of disease 1999;6(4):231-44.
1999: Sucheta Kulkarni; Takaomi C Saido; K Suzuki; Joan E B Fox
Calpain mediates integrin-induced signaling at a point upstream of Rho family members.
The Journal of biological chemistry 1999;274(30):21265-75.
1999: Hisashi Koike; H Seki; Z Kouchi; M Ito; T Kinouchi; Sachiko Tomioka; Hiroyuki Sorimachi; Takaomi C Saido; Kei Maruyama; Kazutoshi Suzuki; Shoichi Ishiura
Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells.
Journal of biochemistry 1999;126(1):235-42.
1999: Klas Blomgren; Ulrika Hallin; Anna-Lena Andersson; M Puka-Sundvall; Ben A Bahr; A McRae; Takaomi C Saido; S Kawashima; Henrik Hagberg
Calpastatin is up-regulated in response to hypoxia and is a suicide substrate to calpain after neonatal cerebral hypoxia-ischemia.
The Journal of biological chemistry 1999;274(20):14046-52.
1999: Kazuo Kitagawa; Masayasu Matsumoto; Takaomi C Saido; Toshiho Ohtsuki; Keisuke Kuwabara; Yoshiki Yagita; Takuma Mabuchi; Takehiko Yanagihara; Masatsugu Hori
Species differences in fodrin proteolysis in the ischemic brain.
Journal of neuroscience research 1999;55(5):643-9.
1999: M Yokota; Eiichi Tani; S Tsubuki; I Yamaura; I Nakagaki; S Hori; Takaomi C Saido
Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage.
Brain research 1999;819(1-2):8-14.
1999: Haruhiko Akiyama; Hiroshi Mori; Takaomi C Saido; H Kondo; K Ikeda; Patrick L McGeer
Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease.
Glia 1999;25(4):324-31.
1999: Swapan K Ray; DC Shields; Takaomi C Saido; DC Matzelle; Gloria G Wilford; Edward Leo Hogan; Narendra L. Banik
Calpain activity and translational expression increased in spinal cord injury.
Brain research 1999;816(2):375-80.
1999: T Honda; K Yasutake; N Nihonmatsu; M Mercken; H Takahashi; Ohoshi Murayama; Miyuki Murayama; K Sato; A Omori; S Tsubuki; Takaomi C Saido; Akihiko Takashima
Dual roles of proteasome in the metabolism of presenilin 1.
Journal of neurochemistry 1999;72(1):255-61.
1998: R Hosoda; Takaomi C Saido; L Otvos; T Arai; D M A Mann; Virginia M-Y Lee; John Q Trojanowski; Takeshi Iwatsubo
Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains.
Journal of neuropathology and experimental neurology 1998;57(11):1089-95.
1998: Sally A Frautschy; D L Horn; JJ Sigel; Marni E Harris-White; J J Mendoza; Fusheng Yang; Takaomi C Saido; Gregory M. Cole
Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8311-21.
1998: S Sudoh; Yuuki Kawamura; S Sato; Rong Wang; Takaomi C Saido; F Oyama; Y Sakaki; Hiroto Komano; Katsuhiko Yanagisawa
Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.
Journal of neurochemistry 1998;71(4):1535-43.
1998: Taisuke Tomita; S Tokuhiro; Tadafumi Hashimoto; K Aiba; Takaomi C Saido; Kei Maruyama; Takeshi Iwatsubo
Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.
The Journal of biological chemistry 1998;273(33):21153-60.
1998: Yasuko Ono; H Shimada; Hiroyuki Sorimachi; I Richard; Takaomi C Saido; Jacques Beckmann; Shoichi Ishiura; Kazutoshi Suzuki
Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A.
The Journal of biological chemistry 1998;273(27):17073-8.
1998: Fumitaka Oyama; N Sawamura; K Kobayashi; Maho Morishima-Kawashima; T Kuramochi; Mie Ito; Taisuke Tomita; Kei Maruyama; Takaomi C Saido; Takeshi Iwatsubo; Anja Capell; Jochen Walter; J Grünberg; Yoshito Ueyama; Christian Haass; Yasuo Ihara
Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Journal of neurochemistry 1998;71(1):313-22.
1998: K Shinozaki; Kei Maruyama; H Kume; Taisuke Tomita; Takaomi C Saido; Takeshi Iwatsubo; Kunihiko Obata
The presenilin 2 loop domain interacts with the mu-calpain C-terminal region.
International journal of molecular medicine 1998;1(5):797-9.
1998: Teresa Zalewska; B Zabłocka; Takaomi C Saido; Halina Zajac; K Domańska-Janik
Dual response of calpain to rat brain postdecapitative ischemia.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1998;33(3):185-97.
1998: H Funato; M Yoshimura; T Yamazaki; Takaomi C Saido; Y Ito; J Yokofujita; Riki Okeda; Yasuo Ihara
Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain.
The American journal of pathology 1998;152(4):983-92.
1998: S Tokuhiro; Taisuke Tomita; H Iwata; T Kosaka; Takaomi C Saido; Kei Maruyama; Takeshi Iwatsubo
The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells.
Biochemical and biophysical research communications 1998;244(3):751-5.
1998: Haruyasu Yamaguchi; S Sugihara; A Ogawa; Takaomi C Saido; Yasuo Ihara
Diffuse plaques associated with astroglial amyloid beta protein, possibly showing a disappearing stage of senile plaques.
Acta neuropathologica 1998;95(3):217-22.
1998: M Luise Schmidt; Virginia M-Y Lee; Takaomi C Saido; Daniel P Perl; Teresa Schuck; Takeshi Iwatsubo; John Q Trojanowski
Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging.
Acta neuropathologica 1998;95(2):117-22.
1998: TL Tekirian; Takaomi C Saido; William R Markesbery; M J Russell; David R Wekstein; E Patel; James W Geddes
N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits.
Journal of neuropathology and experimental neurology 1998;57(1):76-94.
1998: Takaomi C Saido
Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid.
Neurobiology of aging 1998;19(1 Suppl):S69-75.
1998: Sally A Frautschy; Fusheng Yang; M Irrizarry; Bradley T Hyman; Takaomi C Saido; Karen K. Hsiao Ashe; Gregory M. Cole
Microglial response to amyloid plaques in APPsw transgenic mice.
The American journal of pathology 1998;152(1):307-17.
1997: Ryong-Woon Shin; K Ogino; A Kondo; Takaomi C Saido; John Q Trojanowski; Tetsuyuki Kitamoto; Jun Tateishi
Amyloid beta-protein (Abeta) 1-40 but not Abeta1-42 contributes to the experimental formation of Alzheimer disease amyloid fibrils in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(21):8187-93.
1997: Shi Du Yan; J Fu; C Soto; Xi Chen; Huixiang Zhu; Futwan Al-Mohanna; Katharine Collison; A Zhu; E Stern; Takaomi C Saido; M Tohyama; S Ogawa; Alex Roher; David M Stern
An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.
Nature 1997;389(6652):689-95.
1997: Klas Blomgren; A McRae; A Elmered; E Bona; S Kawashima; Takaomi C Saido; T Ono; Henrik Hagberg
The calpain proteolytic system in neonatal hypoxic-ischemia.
Annals of the New York Academy of Sciences 1997;825():104-19.
1997: Takaomi C Saido; M Yokota
[Neurodegenerative diseases as proteolytic disorders: brain ischemia and Alzheimer's disease].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(14 Suppl):2408-17.
1997: T Yamazaki; Christian Haass; Takaomi C Saido; S Omura; Yasuo Ihara
Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition.
Biochemistry 1997;36(27):8377-83.
1997: Claudio Russo; Takaomi C Saido; L M DeBusk; Massimo Tabaton; Pierluigi Gambetti; JK Teller
Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Down's syndrome brains.
FEBS letters 1997;409(3):411-6.
1997: Takaomi C Saido; S Kawashima; E Tani; M Yokota
Up- and down-regulation of calpain inhibitor polypeptide, calpastatin, in postischemic hippocampus.
Neuroscience letters 1997;227(2):75-8.
1997: Taisuke Tomita; Kei Maruyama; Takaomi C Saido; H Kume; K Shinozaki; S Tokuhiro; Anja Capell; Jochen Walter; J Grünberg; Christian Haass; Takeshi Iwatsubo; Kunihiko Obata
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):2025-30.
1997: T Kuda; Mikio Shoji; Hiroyuki Arai; S Kawashima; Takaomi C Saido
Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer's disease.
Biochemical and biophysical research communications 1997;231(3):526-30.
1997: D M A Mann; Stuart Pickering-Brown; N N Bayatti; A E Wright; F Owen; Takeshi Iwatsubo; Takaomi C Saido
An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid beta protein deposited in Alzheimer's disease.
Neuroscience letters 1997;222(1):57-60.
1997: D M A Mann; Takeshi Iwatsubo; Stuart Pickering-Brown; F Owen; Takaomi C Saido; Robert H Perry
Preferential deposition of amyloid beta protein (Abeta) in the form Abeta40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele.
Neuroscience letters 1997;221(2-3):81-4.
1996: Takeshi Iwatsubo; Takaomi C Saido; D M A Mann; Virginia M-Y Lee; John Q Trojanowski
Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.
The American journal of pathology 1996;149(6):1823-30.
1996: M Yokota; Takaomi C Saido; Eiichi Tani; I Yamaura; N Minami
Cytotoxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(6):1219-23.
1996: Kei Maruyama; Taisuke Tomita; K Shinozaki; H Kume; H Asada; Takaomi C Saido; S Ishiura; Takeshi Iwatsubo; Kunihiko Obata
Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).
Biochemical and biophysical research communications 1996;227(3):730-5.
1996: Cynthia A Lemere; Francisco Lopera; Kenneth S Kosik; Corinne Lendon; Jorge E Ossa; Takaomi C Saido; Haruyasu Yamaguchi; A Ruiz; A Martinez; L Madrigal; L Hincapie; JC Arango; D C Anthony; Edward H Koo; Alison Goate; Dennis J Selkoe; J C Arango
The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.
Nature medicine 1996;2(10):1146-50.
1996: Takaomi C Saido; W Yamao-Harigaya; Takeshi Iwatsubo; S Kawashima
Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain.
Neuroscience letters 1996;215(3):173-6.
1996: Takaomi C Saido
[Spatial resolution of proteolytic reactions in brain ischemia and Alzheimer's disease].
Seikagaku. The Journal of Japanese Biochemical Society 1996;68(9):1507-22.
1996: Tetsumori Yamashima; Takaomi C Saido; M Takita; A Miyazawa; J Yamano; A Miyakawa; H Nishijyo; Junkoh Yamashita; S Kawashima; T Ono; T Yoshioka
Transient brain ischaemia provokes Ca2+, PIP2 and calpain responses prior to delayed neuronal death in monkeys.
The European journal of neuroscience 1996;8(9):1932-44.
1996: Y Saito; K Maruyama; H Kawano; K Hagino-Yamagishi; K Kawamura; Takaomi C Saido; S Kawashima
Molecular cloning and characterization of a novel form of neuropeptide gene as a developmentally regulated molecule.
The Journal of biological chemistry 1996;271(26):15615-22.
1996: H Kume; Kei Maruyama; Taisuke Tomita; Takeshi Iwatsubo; Takaomi C Saido; Kunihiko Obata
Molecular cloning of a novel basic helix-loop-helix protein from the rat brain.
Biochemical and biophysical research communications 1996;219(2):526-30.
1996: Cynthia A Lemere; J K Blusztajn; Haruyasu Yamaguchi; Thomas Wisniewski; Takaomi C Saido; Dennis J Selkoe
Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.
Neurobiology of disease 1996;3(1):16-32.
1995: Y Saito; K Maruyama; Takaomi C Saido; S Kawashima
N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin.
Biochemical and biophysical research communications 1995;217(2):539-45.
1995: E Bednarski; P Vanderklish; C Gall; Takaomi C Saido; Ben A Bahr; Gary Lynch
Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices.
Brain research 1995;694(1-2):147-57.
1995: M Yokota; Takaomi C Saido; Eiichi Tani; S Kawashima; K Suzuki
Three distinct phases of fodrin proteolysis induced in postischemic hippocampus. Involvement of calpain and unidentified protease.
Stroke; a journal of cerebral circulation 1995;26(10):1901-7.
1995: P Vanderklish; Takaomi C Saido; C Gall; A Arai; Gary Lynch
Proteolysis of spectrin by calpain accompanies theta-burst stimulation in cultured hippocampal slices.
Brain research. Molecular brain research 1995;32(1):25-35.
1995: Klas Blomgren; S Kawashima; Takaomi C Saido; Jan-Olof Karlsson; A Elmered; Henrik Hagberg
Fodrin degradation and subcellular distribution of calpains after neonatal rat cerebral hypoxic-ischemia.
Brain research 1995;684(2):143-9.
1995: Yasuo Harigaya; Mikio Shoji; Takeshi Kawarabayashi; Mitsuyasu Kanai; T Nakamura; T Iizuka; Yukifusa Igeta; Takaomi C Saido; N Sahara; Hiroshi Mori
Modified amyloid beta protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer's disease.
Biochemical and biophysical research communications 1995;211(3):1015-22.
1995: K Mizuno; K Noda; Y Ueda; H Hanaki; Takaomi C Saido; T Ikuta; T Kuroki; T Tamaoki; S Hirai; S Osada
UCN-01, an anti-tumor drug, is a selective inhibitor of the conventional PKC subfamily.
FEBS letters 1995;359(2-3):259-61.
1995: Takaomi C Saido; Takeshi Iwatsubo; D M A Mann; H Shimada; Yasuo Ihara; S Kawashima
Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.
Neuron 1995;14(2):457-66.
1994: Y Saito; Takaomi C Saido; K Sano; S Kawashima
The calpain-calpastatin system is regulated differently during human neuroblastoma cell differentiation to Schwannian and neuronal cells.
FEBS letters 1994;353(3):327-31.
1994: Takaomi C Saido; M Yokota; K Maruyama; W Yamao-Harigaya; E Tani; Yasuo Ihara; S Kawashima
Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus.
The Journal of biological chemistry 1994;269(21):15253-7.
1994: Hiroyuki Sorimachi; Takaomi C Saido; K Suzuki
New era of calpain research. Discovery of tissue-specific calpains.
FEBS letters 1994;343(1):1-5.
1994: M Yokota; Takaomi C Saido; K Miyaji; Eiichi Tani; S Kawashima; K Suzuki
Stimulation of protein-tyrosine phosphorylation in gerbil hippocampus after global forebrain ischemia.
Neuroscience letters 1994;168(1-2):69-72.
1993: Takaomi C Saido; M Yokota; S Nagao; I Yamaura; E Tani; T Tsuchiya; K Suzuki; S Kawashima
Spatial resolution of fodrin proteolysis in postischemic brain.
The Journal of biological chemistry 1993;268(33):25239-43.
1993: I Yamaura; Eiichi Tani; Takaomi C Saido; K Suzuki; N Minami; Y Maeda
Calpain-calpastatin system of canine basilar artery in vasospasm.
Journal of neurosurgery 1993;79(4):537-43.
1993: Hiroyuki Sorimachi; Noriko Toyama-Sorimachi; Takaomi C Saido; H Kawasaki; H Sugita; M Miyasaka; K Arahata; Shoichi Ishiura; K Suzuki
Muscle-specific calpain, p94, is degraded by autolysis immediately after translation, resulting in disappearance from muscle.
The Journal of biological chemistry 1993;268(14):10593-605.
1992: K Suzuki; Takaomi C Saido; S Hirai
Modulation of cellular signals by calpain.
Annals of the New York Academy of Sciences 1992;674():218-27.
1992: S Kawashima; Takaomi C Saido
[Physiological function of calpains].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1992;37(12):2144-60.
1992: Takaomi C Saido; K Mizuno; Y Konno; S Osada; Shigeo Ohno; K Suzuki
Purification and characterization of protein kinase C epsilon from rabbit brain.
Biochemistry 1992;31(2):482-90.
1991: K Mizuno; K Kubo; Takaomi C Saido; Y Akita; S Osada; T Kuroki; S Ohno; K Suzuki
Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta.
European journal of biochemistry / FEBS 1991;202(3):931-40.
1991: A Mori; H Aizawa; Takaomi C Saido; H Kawasaki; K Mizuno; Hiromu Murofushi; K Suzuki; H Sakai
Site-specific phosphorylation by protein kinase C inhibits assembly-promoting activity of microtubule-associated protein 4.
Biochemistry 1991;30(38):9341-6.
1990: Takaomi C Saido; K Suzuki
[Calcium-activated neutral proteases in cell injury].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1990;35(10):1864-70.
1990: Y Kobayashi; K Yamamoto; Takaomi C Saido; H Kawasaki; Joost J Oppenheim; K Matsushima
Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5548-52.
1987: Takaomi C Saido; S Toyoshima; T Osawa
Protein-O-carboxylmethyltransferase from cytosol and membranes of chicken erythrocytes.
Journal of biochemistry 1987;102(2):319-26.