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Nagahiro Saijo

Research Profile

Disorders

Chemicals & Drugs

Procedures

Anatomy

Tumor Cells, Cultured

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Japan

Concepts & Ideas

Physiology

Drug Resistance

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Publications

TOP 3
Yasuo Ohashi; Hironobu Ohmatsu; Rumiko Okamoto; Nagahiro Saijo; Toru Sugiyama; Yukari Uemura; Yasuhito Fujisaka; Noriyuki Katsumata; Tomomitsu Hotta
Meta-analysis of epoetin beta and darbepoetin alfa treatment for chemotherapy-induced anemia and mortality: Individual patient data from Japanese randomized, placebo-controlled trials.
Nagahiro Saijo
The role of pharmacoethnicity in the development of cytotoxic and molecular targeted drugs in oncology.
Nagahiro Saijo
[Present status and future prospects of antibody therapy against solid tumor].

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All Publications

2013: Yasuo Ohashi; Hironobu Ohmatsu; Rumiko Okamoto; Nagahiro Saijo; Toru Sugiyama; Yukari Uemura; Yasuhito Fujisaka; Noriyuki Katsumata; Tomomitsu Hotta
Meta-analysis of epoetin beta and darbepoetin alfa treatment for chemotherapy-induced anemia and mortality: Individual patient data from Japanese randomized, placebo-controlled trials.
Cancer science 2013;104(4):481-5.
2013: Nagahiro Saijo
The role of pharmacoethnicity in the development of cytotoxic and molecular targeted drugs in oncology.
Yonsei medical journal 2013;54(1):1-14.
2012: Nagahiro Saijo
[Present status and future prospects of antibody therapy against solid tumor].
Nihon rinsho. Japanese journal of clinical medicine 2012;70(12):2051-7.
2012: Minoru Tada; Takashi Ura; Yasuhide Yamada; Teruhiko Yoshida; Takayuki Yoshino; Toshihiko Doi; Hiromi Fukushima-Uesaka; Nozomu Fuse; Tetsuya Hamaguchi; Akiko Ishii-Watabe; Nahoko Kaniwa; Ken Kato; Nana Kawasaki; Kouichi Kurose; Keiko Maekawa; Kei Muro; Takako Eguchi Nakajima; Atsushi Ohtsu; Haruhiro Okuda; Nagahiro Saijo; Miyuki Saito; Yoshiro Saito; Jun-Ichi Sawada; Yasuhiro Shimada; Takuo Suzuki; Yasuhiro Matsumura
Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant.
Immunogenetics 2012;64(12):869-77.
2012: Nagahiro Saijo
[Combination therapy of targeted drugs].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():652-7.
2012: Nagahiro Saijo
[History of cancer chemotherapy; from cytotoxic drugs to molecular targeted therapy].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():18-23.
2012: Yoshihiko Fujita; Hideharu Kimura; Kazuko Matsumoto; Tetsuya Mitsudomi; Tomoyuki Nagai; Nagahiro Saijo; Kenichi Suda; Yasushi Yatabe; Tokuzo Arao; Kazuto Nishio
Highly sensitive detection of EGFR T790M mutation using colony hybridization predicts favorable prognosis of patients with lung cancer harboring activating EGFR mutation.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(11):1640-4.
2012: S Niho; Y Ohe; H Okamoto; Nagahiro Saijo; T Shibata; K Takeda; Tomohide Tamura; A Yokoyama; S Atagi; Y Ichinose; S Ishikura; M Fukuoka
Induction chemotherapy followed by gefitinib and concurrent thoracic radiotherapy for unresectable locally advanced adenocarcinoma of the lung: a multicenter feasibility study (JCOG 0402).
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2012;23(9):2253-8.
2012: Shinji Atagi; Haruhiko Fukuda; Satoshi Ishikura; Masaaki Kawahara; Yuichiro Ohe; Hiroaki Okamoto; Nagahiro Saijo; Toshiyuki Sawa; Taro Shibata; Tomohide Tamura; Nobuyuki Yamamoto; Akira Yokoyama
Thoracic radiotherapy with or without daily low-dose carboplatin in elderly patients with non-small-cell lung cancer: a randomised, controlled, phase 3 trial by the Japan Clinical Oncology Group (JCOG0301).
The lancet oncology 2012;13(7):671-8.
2012: Seiji Niho; Hiroshi Nokihara; Hiroaki Okamoto; Nagahiro Saijo; Hiroshi Sakai; Tetsu Shinkai; Koji Takeda; Nobuyuki Yamamoto; Soichiro Yokota; Akira Yokoyama; Masahiro Fukuoka; Toyoaki Hida; Takeshi Horai; Yukito Ichinose; Masaaki Kawahara; Katsuyuki Kiura; Shinzoh Kudoh; Hideo Kunitoh; Kaoru Matsui; Kiyoshi Mori; Kazuhiko Nakagawa; Shunichi Negoro
Randomized phase II study of first-line carboplatin-paclitaxel with or without bevacizumab in Japanese patients with advanced non-squamous non-small-cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2012;76(3):362-7.
2012: Nagahiro Saijo
Problems involved in the clinical trials for non-small cell lung carcinoma.
Cancer treatment reviews 2012;38(3):194-202.
2012: Takeshi Mera; Nagahiro Saijo; Hideyuki Akaza
[Safety and efficacy of docetaxel in prostate cancer patients: based on the post-marketing surveillance in Japan].
Gan to kagaku ryoho. Cancer & chemotherapy 2012;39(4):551-62.
2012: Nagahiro Saijo
Present status and problems on molecular targeted therapy of cancer.
Cancer research and treatment : official journal of Korean Cancer Association 2012;44(1):1-10.
2012: Nagahiro Saijo
Critical comments for roles of biomarkers in the diagnosis and treatment of cancer.
Cancer treatment reviews 2012;38(1):63-7.
2011: Sumitra Thongprasert; Yi-Long Wu; James Chih-Hsin Yang; Alison Armour; Yuh-Min Chen; Da-Tong Chu; Emma Duffield; Han-Pin Kuo; Kwok Chi Lam; Meilin Liao; Patrick Magill; Shunichi Negoro; Nagahiro Saijo; Masahiro Fukuoka
Health-related quality-of-life in a randomized phase III first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients from Asia with advanced NSCLC (IPASS).
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(11):1872-80.
2011: Makoto Nishio; Tatsuo Ohira; Nagahiro Saijo; Asao Sakai; Kazuko Sakai; Takashi Sone; Takeharu Yamanaka; Tokuzo Arao; Atsushi Horiike; Norihiko Ikeda; Kazuo Kasahara; Hideharu Kimura; Fumiaki Koizumi; Kazuko Matsumoto; Kazuto Nishio
Serum heparan sulfate concentration is correlated with the failure of epidermal growth factor receptor tyrosine kinase inhibitor treatment in patients with lung adenocarcinoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(11):1889-94.
2011: Nagahiro Saijo
Preface for JCOG review series.
Japanese journal of clinical oncology 2011;41(10):1155.
2011: Masahiro Fukuoka; Haiyi Jiang; Swan-Swan Leong; Alison A Armour; Tsu-Yi Chao; Da-Tong Chu; Emma L Duffield; Kazuhiko Nakagawa; Yuri Rukazenkov; Nagahiro Saijo; Georgina Speake; Virote Sriuranpong; Patrapim Sunpaweravong; Sumitra Thongprasert; Ka-Fai To; Yi-Long Wu; James Chih-Hsin Yang; Tony Shu Kam Mok
Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS).
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(21):2866-74.
2011: Harubumi Kato; Toshihide Nishimura; Norihiko Ikeda; Tesshi Yamada; Tadashi Kondo; Nagahiro Saijo; Kazuto Nishio; Junichiro Fujimoto; Masaharu Nomura; Yoshiya Oda; Bertil Lindmark; Jiro Maniwa; Hitoshi Hibino; Michiaki Unno; Toshinori Ito; Yoshiki Sawa; Hiromasa Tojo; Shin Egawa; Goutham Edula; Mary Lopez; Murray Wigmore; Naohiko Inase; Yasuyuki Yoshizawa; Fumio Nomura; György Marko-Varga
Developments for a growing Japanese patient population: facilitating new technologies for future health care.
Journal of proteomics 2011;74(6):759-64.
2011: Kanae Kudo; Tokuzo Arao; Kaoru Tanaka; Tomoyuki Nagai; Kazuyuki Furuta; Kazuko Sakai; Hiroyasu Kaneda; Kazuko Matsumoto; Daisuke Tamura; Keiichi Aomatsu; Marco De Velasco; Yoshihiko Fujita; Nagahiro Saijo; Masatoshi Kudo; Kazuto Nishio
Antitumor activity of BIBF 1120, a triple angiokinase inhibitor, and use of VEGFR2+pTyr+ peripheral blood leukocytes as a pharmacodynamic biomarker in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(6):1373-81.
2011: Tomoyuki Nagai; Tokuzo Arao; Kazuyuki Furuta; Kazuko Sakai; Kanae Kudo; Hiroyasu Kaneda; Daisuke Tamura; Keiichi Aomatsu; Hideharu Kimura; Yoshihiko Fujita; Kazuko Matsumoto; Nagahiro Saijo; Masatoshi Kudo; Kazuto Nishio
Sorafenib inhibits the hepatocyte growth factor-mediated epithelial mesenchymal transition in hepatocellular carcinoma.
Molecular cancer therapeutics 2011;10(1):169-77.
2011: Yoshiro Saito; Noboru Yamamoto; Noriko Katori; Keiko Maekawa; Hiromi Fukushima-Uesaka; Daisuke Sugimoto; Kouichi Kurose; Kimie Sai; Nahoko Kaniwa; Jun-Ichi Sawada; Hideo Kunitoh; Yuichiro Ohe; Teruhiko Yoshida; Yasuhiro Matsumura; Nagahiro Saijo; Haruhiro Okuda; Tomohide Tamura
Genetic polymorphisms and haplotypes of por, encoding cytochrome p450 oxidoreductase, in a Japanese population.
Drug metabolism and pharmacokinetics 2011;26(1):107-16.
2011: Yasunori Sato; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Hironobu Minami; Nan M Laird; Noriko Katori; Yoshiro Saito; Sumiko Ohnami; Hiromi Sakamoto; Jun-Ichi Sawada; Nagahiro Saijo; Teruhiko Yoshida; Tomohide Tamura
Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(1):132-8.
2011: Koji Takeda; Shunichi Negoro; Masahiro Tanaka; Haruhiko Fukuda; Kazuhiko Nakagawa; Masaaki Kawahara; Hiroshi Semba; Shinzoh Kudoh; Toshiyuki Sawa; Nagahiro Saijo; Masahiro Fukuoka
A phase II study of cisplatin and irinotecan as induction chemotherapy followed by concomitant thoracic radiotherapy with weekly low-dose irinotecan in unresectable, stage III, non-small cell lung cancer: JCOG 9706.
Japanese journal of clinical oncology 2011;41(1):25-31.
2010: Primo Lara; Kari Chansky; Taro Shibata; Haruhiko Fukuda; Tomohide Tamura; John Crowley; Mary W Redman; Ronald Natale; Nagahiro Saijo; David R Gandara
Common arm comparative outcomes analysis of phase 3 trials of cisplatin + irinotecan versus cisplatin + etoposide in extensive stage small cell lung cancer: final patient-level results from Japan Clinical Oncology Group 9511 and Southwest Oncology Group 0124.
Cancer 2010;116(24):5710-5.
2010: Nagahiro Saijo
Targeted therapies: Tyrosine-kinase inhibitors--new standard for NSCLC therapy.
Nature reviews. Clinical oncology 2010;7(11):618-9.
2010: Nagahiro Saijo
[Molecular target therapy in cancer].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(10):1779-86.
2010: Kazuo Kasahara; Tokuzo Arao; Kazuko Sakai; Kazuko Matsumoto; Asao Sakai; Hideharu Kimura; Takashi Sone; Atsushi Horiike; Makoto Nishio; Tatsuo Ohira; Norihiko Ikeda; Takeharu Yamanaka; Nagahiro Saijo; Kazuto Nishio
Impact of serum hepatocyte growth factor on treatment response to epidermal growth factor receptor tyrosine kinase inhibitors in patients with non-small cell lung adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(18):4616-24.
2010: Nagahiro Saijo; Masahiro Fukuoka; Sumitra Thongprasert; Yukito Ichinose; Tetsuya Mitsudomi; Tony Shu Kam Mok; Yuichiro Ohe; Keunchil Park; Yi-Long Wu
Lung cancer working group report.
Japanese journal of clinical oncology 2010;40 Suppl 1():i7-12.
2010: Kiyotaka Yoh; Hirotsugu Kenmotsu; Yoko Yamaguchi; Kaoru Kubota; Hironobu Ohmatsu; Koichi Goto; Seiji Niho; Yuichiro Ohe; Nagahiro Saijo; Yutaka Nishiwaki
Severe interstitial lung disease associated with amrubicin treatment.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010;5(9):1435-8.
2010: Nagahiro Saijo
Progress in cancer chemotherapy with special stress on molecular-targeted therapy.
Japanese journal of clinical oncology 2010;40(9):855-62.
2010: Tatsuya Nagano; Young-Hak Kim; Koichi Goto; Kaoru Kubota; Hironobu Ohmatsu; Seiji Niho; Kiyotaka Yoh; Yoichi Naito; Nagahiro Saijo; Yutaka Nishiwaki
Re-challenge chemotherapy for relapsed non-small-cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2010;69(3):315-8.
2010: Aya Miyatake; Teiji Nishio; Takashi Ogino; Nagahiro Saijo; Hiroyasu Esumi; Mitsuru Uesaka
Measurement and verification of positron emitter nuclei generated at each treatment site by target nuclear fragment reactions in proton therapy.
Medical physics 2010;37(8):4445-55.
2010: Kimie Sai; Yoshiro Saito; Naoko Tatewaki; Masakiyo Hosokawa; Nahoko Kaniwa; Tomoko Nishimaki-Mogami; Mikihiko Naito; Jun-Ichi Sawada; Kuniaki Shirao; Tetsuya Hamaguchi; Noboru Yamamoto; Hideo Kunitoh; Tomohide Tamura; Yasuhide Yamada; Yuichiro Ohe; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Yasuhiro Matsumura; Nagahiro Saijo; Haruhiro Okuda
Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients.
British journal of clinical pharmacology 2010;70(2):222-33.
2010: Emiko Sugiyama; Nahoko Kaniwa; Su-Ryang Kim; Ryuichi Hasegawa; Yoshiro Saito; Hideki Ueno; Takuji Okusaka; Masafumi Ikeda; Chigusa Morizane; Shunsuke Kondo; Noboru Yamamoto; Tomohide Tamura; Junji Furuse; Hiroshi Ishii; Teruhiko Yoshida; Nagahiro Saijo; Jun-Ichi Sawada
Population pharmacokinetics of gemcitabine and its metabolite in Japanese cancer patients: impact of genetic polymorphisms.
Clinical pharmacokinetics 2010;49(8):549-58.
2010: Nobuyuki Yamamoto; Takeharu Yamanaka; Yukito Ichinose; Kaoru Kubota; Hiroshi Sakai; Akihiko Gemma; Nagahiro Saijo; Masahiro Fukuoka; Hisanobu Niitani
Pooled analysis of S-1 trials in non-small cell lung cancer according to histological type.
Anticancer research 2010;30(7):2985-90.
2010: Roy S Herbst; Yan Sun; Wilfried E E Eberhardt; Paul Germonpré; Nagahiro Saijo; Caicun Zhou; Jie Wang; Longyun Li; Fairooz Kabbinavar; Yukito Ichinose; Shukui Qin; Li Zhang; Bonne Biesma; John V Heymach; Peter Langmuir; Sarah J Kennedy; Hiroomi Tada; Bruce E Johnson
Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial.
The lancet oncology 2010;11(7):619-26.
2010: Nobuyuki Yamamoto; Yutaka Nishiwaki; Shunichi Negoro; Haiyi Jiang; Yohji Itoh; Nagahiro Saijo; Masahiro Fukuoka
Disease control as a predictor of survival with gefitinib and docetaxel in a phase III study (V-15-32) in advanced non-small cell lung cancer patients.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010;5(7):1042-7.
2010: Nagahiro Saijo
[Treatment with antiangiogenic drugs].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(6):1007-13.
2010: Yukito Ichinose; Takashi Seto; Yutaka Nishiwaki; Yuichiro Ohe; Yoshiharu Yamada; Koji Takeda; Nagahiro Saijo; Tomomitsu Hotta
Randomized phase 2 dose-finding study of weekly administration of darbepoetin alpha in anemic patients with lung or ovarian cancer receiving multicycle platinum-containing chemotherapy.
Japanese journal of clinical oncology 2010;40(6):521-9.
2010: Daisuke Tamura; Tokuzo Arao; Kaoru Tanaka; Hiroyasu Kaneda; Kazuko Matsumoto; Kanae Kudo; Keiichi Aomatsu; Yoshihiko Fujita; Takashi Watanabe; Nagahiro Saijo; Yoshikazu Kotani; Yoshihiro Nishimura; Kazuto Nishio
Bortezomib potentially inhibits cellular growth of vascular endothelial cells through suppression of G2/M transition.
Cancer science 2010;101(6):1403-8.
2010: Kaoru Kubota; Hiroshi Sakai; Nobuyuki Yamamoto; Hideo Kunitoh; Kazuhiko Nakagawa; Koji Takeda; Yukito Ichinose; Nagahiro Saijo; Yutaka Ariyoshi; Masahiro Fukuoka
A multi-institution phase I/II trial of triweekly regimen with S-1 plus cisplatin in patients with advanced non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010;5(5):702-6.
2010: Kimie Sai; Yoshiro Saito; Keiko Maekawa; Su-Ryang Kim; Nahoko Kaniwa; Tomoko Nishimaki-Mogami; Jun-ichi Sawada; Kuniaki Shirao; Tetsuya Hamaguchi; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Yasuhide Yamada; Tomohide Tamura; Teruhiko Yoshida; Yasuhiro Matsumura; Atsushi Ohtsu; Nagahiro Saijo; Hironobu Minami
Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients.
Cancer chemotherapy and pharmacology 2010;66(1):95-105.
2010: Junichi Matsubara; Masaya Ono; Kazufumi Honda; Ayako Negishi; Hideki Ueno; Takuji Okusaka; Junji Furuse; Koh Furuta; Emiko Sugiyama; Yoshiro Saito; Nahoko Kaniwa; Junichi Sawada; Ayako Shoji; Tomohiro Sakuma; Tsutomu Chiba; Nagahiro Saijo; Setsuo Hirohashi; Tesshi Yamada
Survival prediction for pancreatic cancer patients receiving gemcitabine treatment.
Molecular & cellular proteomics : MCP 2010;9(4):695-704.
2010: Martin D Forster; Nagahiro Saijo; Lesley Seymour; Hilary Calvert
Performing phase I clinical trials of anticancer agents: perspectives from within the European union and Japan.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(6):1737-44.
2010: Toshiaki Takahashi; Nobuyuki Yamamoto; Toshihiro Nukiwa; Kiyoshi Mori; Masahiro Tsuboi; Takeshi Horai; Noriyuki Masuda; Kenji Eguchi; Tetsuya Mitsudomi; Soichiro Yokota; Yoshihiko Segawa; Yukito Ichinose; Masahiro Fukuoka; Nagahiro Saijo
Phase II study of erlotinib in Japanese patients with advanced non-small cell lung cancer.
Anticancer research 2010;30(2):557-63.
2010: Akiko Ishii-Watabe; Yoshiro Saito; Takuo Suzuki; Minoru Tada; Maho Ukaji; Keiko Maekawa; Kouichi Kurose; Nahoko Kaniwa; Jun-ichi Sawada; Nana Kawasaki; Teruhide Yamaguchi; Takako Eguchi Nakajima; Ken Kato; Yasuhide Yamada; Yasuhiro Shimada; Teruhiko Yoshida; Takashi Ura; Miyuki Saito; Kei Muro; Toshihiko Doi; Nozomu Fuse; Takayuki Yoshino; Atsushi Ohtsu; Nagahiro Saijo; Tetsuya Hamaguchi; Haruhiro Okuda; Yasuhiro Matsumura
Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis.
Drug metabolism and pharmacokinetics 2010;25(6):578-87.
2010: Nagahiro Saijo; Hirotsugu Kenmotsu
Recent development of molecular-targeted drugs in lung cancer.
Internal medicine (Tokyo, Japan) 2010;49(18):1923-34.
2010: Teiji Nishio; Aya Miyatake; Takashi Ogino; Keiichi Nakagawa; Nagahiro Saijo; Hiroyasu Esumi
The development and clinical use of a beam ON-LINE PET system mounted on a rotating gantry port in proton therapy.
International journal of radiation oncology, biology, physics 2010;76(1):277-86.
2009: Tomoki Fujii; Hiroshi Kunikane; Hiroaki Okamoto; Koshiro Watanabe; Hideo Kunitoh; Kiyoshi Mori; Akira Yokoyama; Haruhiko Fukuda; Tomohide Tamura; Nagahiro Saijo
A phase II study of cisplatin and irinotecan as induction chemotherapy followed by accelerated hyperfractionated thoracic radiotherapy with daily low-dose carboplatin in unresectable stage III non-small cell lung cancer: JCOG 9510.
Japanese journal of clinical oncology 2009;39(12):784-90.
2009: Kaoru Kubota; Seiji Niho; Sotarou Enatsu; Yoshihiro Nambu; Yutaka Nishiwaki; Nagahiro Saijo; Masahiro Fukuoka
Efficacy differences of pemetrexed by histology in pretreated patients with stage IIIB/IV non-small cell lung cancer: review of results from an open-label randomized phase II study.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009;4(12):1530-6.
2009: Noboru Yamamoto; Tomohide Tamura; Takayasu Kurata; Nobuyuki Yamamoto; Ikuo Sekine; Hideo Kunitoh; Yuichiro Ohe; Nagahiro Saijo
A dose-finding and pharmacokinetic study of nedaplatin in elderly patients with advanced non-small cell lung cancer.
Cancer chemotherapy and pharmacology 2009;65(1):79-88.
2009: Heather A Wakelee; Billy W Loo; Kemp H Kernstine; Joe Bill Putnam; Martin J Edelman; Everett E Vokes; Joan H Schiller; Paul Baas; Nagahiro Saijo; Alex Adjei; Glenwood Goss; Hak Choy; David R Gandara
Cooperative group research efforts in thoracic malignancies 2009: a review from the 10th Annual International Lung Cancer Congress.
Clinical lung cancer 2009;10(6):395-404.
2009: Kazuko Matsumoto; Tokuzo Arao; Kaoru Tanaka; Hiroyasu Kaneda; Kanae Kudo; Yoshihiko Fujita; Daisuke Tamura; Keiichi Aomatsu; Tomohide Tamura; Yasuhide Yamada; Nagahiro Saijo; Kazuto Nishio
mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells.
Cancer research 2009;69(18):7160-4.
2009: Toru Mukohara; Hiroyuki Shimada; Naomi Ogasawara; Ryoko Wanikawa; Manami Shimomura; Tetsuya Nakatsura; Genichiro Ishii; Joon Oh Park; Pasi A Janne; Nagahiro Saijo; Hironobu Minami
Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression.
Cancer letters 2009;282(1):14-24.
2009: Tony Shu Kam Mok; Yi-Long Wu; Sumitra Thongprasert; Chih-Hsin Yang; Da-Tong Chu; Nagahiro Saijo; Patrapim Sunpaweravong; Baohui Han; Benjamin Margono; Yukito Ichinose; Yutaka Nishiwaki; Yuichiro Ohe; Jin-Ji Yang; Busyamas Chewaskulyong; Haiyi Jiang; Emma L Duffield; Claire L Watkins; Alison A Armour; Masahiro Fukuoka
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma.
The New England journal of medicine 2009;361(10):947-57.
2009: Randeep Sangha; Primo Lara; Alex A Adjei; Paul Baas; Hak Choy; Laurie E Gaspar; Glenwood Goss; Nagahiro Saijo; Joan H Schiller; Everett E Vokes; David R Gandara
Cooperative group research endeavors in small-cell lung cancer: current and future directions.
Clinical lung cancer 2009;10(5):322-30.
2009: Young-Hak Kim; Kaoru Kubota; Koichi Goto; Kiyotaka Yoh; Seiji Niho; Hironobu Ohmatsu; Nagahiro Saijo; Yutaka Nishiwaki
A phase I study of gemcitabine and carboplatin in patients with advanced non-small cell lung cancer and a performance status of 2.
Japanese journal of clinical oncology 2009;39(9):576-81.
2009: Ikuo Sekine; Y Ichinose; Y Nishiwaki; Noboru Yamamoto; M Tsuboi; K Nakagawa; T Shinkai; S Negoro; F Imamura; K Eguchi; K Takeda; Y Itoh; Tomohide Tamura; Nagahiro Saijo; M Fukuoka
Quality of life and disease-related symptoms in previously treated Japanese patients with non-small-cell lung cancer: results of a randomized phase III study (V-15-32) of gefitinib versus docetaxel.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2009;20(9):1483-8.
2009: David R Gandara; Tomoya Kawaguchi; John Crowley; James Moon; Kiyoyuki Furuse; Masaaki Kawahara; Satoshi Teramukai; Yuichiro Ohe; Kaoru Kubota; Stephen K Williamson; Oliver Gautschi; Heinz-Josef Lenz; howard mcleod; Primo Lara; Charles Arthur Coltman; Masahiro Fukuoka; Nagahiro Saijo; Masanori Fukushima; Philip C Mack
Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(21):3540-6.
2009: Nobuyuki Yamamoto; Ikuo Sekine; Kazuhiko Nakagawa; Minoru Takada; Masahiro Fukuoka; Yusuke Tanigawara; Nagahiro Saijo
A pharmacokinetic and dose escalation study of pegfilgrastim (KRN125) in lung cancer patients with chemotherapy-induced neutropenia.
Japanese journal of clinical oncology 2009;39(7):425-30.
2009: Young-Hak Kim; Genichiro Ishii; Koichi Goto; Shuji Ota; Kaoru Kubota; Yukinori Murata; Michiaki Mishima; Nagahiro Saijo; Yutaka Nishiwaki; Atsushi Ochiai
Expression of breast cancer resistance protein is associated with a poor clinical outcome in patients with small-cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2009;65(1):105-11.
2009: Sojiro Kusumoto; Tomohide Sugiyama; Koichi Ando; Takamichi Hosaka; Hiroo Ishida; Takao Shirai; Toshimitsu Yamaoka; Kentaro Okuda; Takashi Hirose; Tsukasa Ohnishi; Fumiko Inoue; Tomoko Kanome; Tsuyoki Kadofuku; Nagahiro Saijo; Mitsuru Adachii; Tohru Ohmori
Combination effect between bortezomib and tumor necrosis factor alpha on gefitinib-resistant non-small cell lung cancer cell lines.
Anticancer research 2009;29(6):2315-22.
2009: Nagahiro Saijo; Masahiro Takeuchi; Hideo Kunitoh
Reasons for response differences seen in the V15-32, INTEREST and IPASS trials.
Nature reviews. Clinical oncology 2009;6(5):287-94.
2009: Junichi Matsubara; Masaya Ono; Ayako Negishi; Hideki Ueno; Takuji Okusaka; Junji Furuse; Koh Furuta; Emiko Sugiyama; Yoshiro Saito; Nahoko Kaniwa; Junichi Sawada; Kazufumi Honda; Tomohiro Sakuma; Tsutomu Chiba; Nagahiro Saijo; Setsuo Hirohashi; Tesshi Yamada
Identification of a predictive biomarker for hematologic toxicities of gemcitabine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(13):2261-8.
2009: Ikuo Sekine; Chikako Shimizu; Kazuto Nishio; Nagahiro Saijo; Tomohide Tamura
A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with breast cancer.
International journal of clinical oncology 2009;14(2):112-9.
2009: Masahiro Tsuboi; Kohji Ezaki; Kensei Tobinai; Yasuo Ohashi; Nagahiro Saijo
Weekly administration of epoetin beta for chemotherapy-induced anemia in cancer patients: results of a multicenter, Phase III, randomized, double-blind, placebo-controlled study.
Japanese journal of clinical oncology 2009;39(3):163-8.
2009: Hideo Kunitoh; Tomohide Tamura; T Shibata; M Imai; Y Nishiwaki; M Nishio; A Yokoyama; K Watanabe; Kiichiro Noda; Nagahiro Saijo
A randomised trial of intrapericardial bleomycin for malignant pericardial effusion with lung cancer (JCOG9811).
British journal of cancer 2009;100(3):464-9.
2009: Yoshiro Saito; Kimie Sai; Keiko Maekawa; Nahoko Kaniwa; Kuniaki Shirao; Tetsuya Hamaguchi; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Yasuhide Yamada; Tomohide Tamura; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Yasuhiro Matsumura; Nagahiro Saijo; Jun-Ichi Sawada
Close association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 haplotype and its apparent influence on 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronidation in Japanese.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(2):272-6.
2009: Hiromi Fukushima-Uesaka; Yoshiro Saito; Keiko Maekawa; Kouichi Kurose; Emiko Sugiyama; Noriko Katori; Nahoko Kaniwa; Ryuichi Hasegawa; Tetsuya Hamaguchi; Takako Eguchi-Nakajima; Ken Kato; Yasuhide Yamada; Yasuhiro Shimada; Teruhiko Yoshida; Noboru Yamamoto; Hiroshi Nokihara; Hideo Kunitoh; Yuichiro Ohe; Tomohide Tamura; Takashi Ura; Miyuki Saito; Kei Muro; Toshihiko Doi; Nozomu Fuse; Takayuki Yoshino; Atsushi Ohtsu; Nagahiro Saijo; Yasuhiro Matsumura; Haruhiro Okuda; Jun-ichi Sawada
Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients.
Drug metabolism and pharmacokinetics 2009;24(6):565-74.
2009: Naoko Tatewaki; Keiko Maekawa; Noriko Katori; Kouichi Kurose; Nahoko Kaniwa; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Hiroshi Nokihara; Ikuo Sekine; Tomohide Tamura; Teruhiko Yoshida; Nagahiro Saijo; Yoshiro Saito; Jun-ichi Sawada
Genetic variations and haplotype structures of the glutathione S-transferase genes, GSTT1 and GSTM1, in a Japanese patient population.
Drug metabolism and pharmacokinetics 2009;24(1):118-26.
2008: Kaoru Kubota; Yutaka Nishiwaki; Tomohide Tamura; Kazuhiko Nakagawa; Kaoru Matsui; Koshiro Watanabe; Toyoaki Hida; Masaaki Kawahara; Nobuyuki Katakami; Koji Takeda; Akira Yokoyama; Kazumasa Noda; Masahiro Fukuoka; Nagahiro Saijo
Efficacy and safety of erlotinib monotherapy for Japanese patients with advanced non-small cell lung cancer: a phase II study.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(12):1439-45.
2008: Kiyotaka Yoh; Yutaka Nishiwaki; Genichiro Ishii; Koichi Goto; Kaoru Kubota; Hironobu Ohmatsu; Seiji Niho; Kanji Nagai; Nagahiro Saijo
Mutational status of EGFR and KIT in thymoma and thymic carcinoma.
Lung cancer (Amsterdam, Netherlands) 2008;62(3):316-20.
2008: Young-Hak Kim; Koichi Goto; Kiyotaka Yoh; Seiji Niho; Hironobu Ohmatsu; Kaoru Kubota; Nagahiro Saijo; Yutaka Nishiwaki
Performance status and sensitivity to first-line chemotherapy are significant prognostic factors in patients with recurrent small cell lung cancer receiving second-line chemotherapy.
Cancer 2008;113(9):2518-23.
2008: Nagahiro Saijo
Population differences in the use of EGFR-targeted agents.
Clinical advances in hematology & oncology : H&O 2008;6(10):730-2.
2008: Nagahiro Saijo
Advances in the treatment of non-small cell lung cancer.
Cancer treatment reviews 2008;34(6):521-6.
2008: Hideo Kunitoh; Harubumi Kato; M Tsuboi; Hisao Asamura; H Tada; K Nagai; Tetsuya Mitsudomi; T Koike; K Nakagawa; Y Ichinose; M Okada; T Shibata; Nagahiro Saijo
A randomised phase II trial of preoperative chemotherapy of cisplatin-docetaxel or docetaxel alone for clinical stage IB/II non-small-cell lung cancer results of a Japan Clinical Oncology Group trial (JCOG 0204).
British journal of cancer 2008;99(6):852-7.
2008: Osamu Kawai; Genichiro Ishii; Kaoru Kubota; Yukinori Murata; Yoichi Naito; Tetsuya Mizuno; Keiju Aokage; Nagahiro Saijo; Yutaka Nishiwaki; Akihiko Gemma; Syoji Kudoh; Atsushi Ochiai
Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer.
Cancer 2008;113(6):1387-95.
2008: Riichiroh Maruyama; Yutaka Nishiwaki; Tomohide Tamura; Nobuyuki Yamamoto; Masahiro Tsuboi; Kazuhiko Nakagawa; Tetsu Shinkai; Shunichi Negoro; Fumio Imamura; Kenji Eguchi; Koji Takeda; Akira Inoue; Keisuke Tomii; Masao Harada; Noriyuki Masuda; Haiyi Jiang; Yohji Itoh; Yukito Ichinose; Nagahiro Saijo; Masahiro Fukuoka
Phase III study, V-15-32, of gefitinib versus docetaxel in previously treated Japanese patients with non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(26):4244-52.
2008: Kimie Sai; Yoshiro Saito; Hiromi Fukushima-Uesaka; Koichi Kurose; Nahoko Kaniwa; Naoyuki Kamatani; Kuniaki Shirao; Noboru Yamamoto; Tetsuya Hamaguchi; Hideo Kunitoh; Yuichiro Ohe; Tomohide Tamura; Yasuhide Yamada; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Jun-ichi Sawada
Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients.
Cancer chemotherapy and pharmacology 2008;62(3):529-37.
2008: Seiji Niho; Kaoru Kubota; Kiyotaka Yoh; Koichi Goto; Hironobu Ohmatsu; Keiji Nihei; Nagahiro Saijo; Yutaka Nishiwaki
Clinical outcome of chemoradiation therapy in patients with limited-disease small cell lung cancer with ipsilateral pleural effusion.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(7):723-7.
2008: Yuichiro Ohe; Yukito Ichinose; Kazuhiko Nakagawa; Tomohide Tamura; Kaoru Kubota; Nobuyuki Yamamoto; Susumu Adachi; Yoshihiro Nambu; Toshio Fujimoto; Yutaka Nishiwaki; Nagahiro Saijo; Masahiro Fukuoka
Efficacy and safety of two doses of pemetrexed supplemented with folic acid and vitamin B12 in previously treated patients with non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(13):4206-12.
2008: Yoichi Naito; Kaoru Kubota; Keiji Nihei; Tomonori Fujii; Kiyotaka Yoh; Seiji Niho; Koichi Goto; Hironobu Ohmatsu; Nagahiro Saijo; Yutaka Nishiwaki
Concurrent chemoradiotherapy with cisplatin and vinorelbine for stage III non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(6):617-22.
2008: Nagahiro Saijo; Tsuneharu Miki; Yoshinobu Kubota; Seiji Naito; Hideyuki Akaza; Shunji Takahashi; Hironobu Minami
Report from the second Japanese Urological Association-Japanese Society of Medical Oncology joint conference, 2007: 'diagnosis and treatment of urological malignant tumors: how can we promote subspecialists?'.
International journal of urology : official journal of the Japanese Urological Association 2008;15(5):389-93.
2008: Kazuhiko Nakagawa; Koichi Yamazaki; Hideo Kunitoh; Toyoaki Hida; Kenichi Gemba; Tetsu Shinkai; Yukito Ichinose; Susumu Adachi; Yoshihiro Nambu; Nagahiro Saijo; Masahiro Fukuoka
Efficacy and safety of pemetrexed in combination with cisplatin for malignant pleural mesothelioma: a phase I/II study in Japanese patients.
Japanese journal of clinical oncology 2008;38(5):339-46.
2008: Katsuyuki Kiura; Kazuhiko Nakagawa; Tetsu Shinkai; Kenji Eguchi; Yuichiro Ohe; Nobuyuki Yamamoto; Masahiro Tsuboi; Soichiro Yokota; Takashi Seto; Haiyi Jiang; Kazuto Nishio; Nagahiro Saijo; Masahiro Fukuoka
A randomized, double-blind, phase IIa dose-finding study of Vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(4):386-93.
2008: Kimie Sai; Yoshiro Saito; Hiromi Sakamoto; Kuniaki Shirao; Koichi Kurose; Mayumi Saeki; Shogo Ozawa; Nahoko Kaniwa; Setsuo Hirohashi; Nagahiro Saijo; Jun-ichi Sawada; Teruhiko Yoshida
Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients.
Cancer letters 2008;261(2):165-71.
2008: Corey J Langer; Heather A Wakelee; Joan Schiller; Hak Choy; Frances Shepherd; Everett E Vokes; Alex A. Adjei; Paul Baas; Nagahiro Saijo; David R Gandara
Cooperative group portfolio in locally advanced non-small-cell lung cancer: are we making progress?
Clinical lung cancer 2008;9(2):85-91.
2008: Yasuhiro Suzuki; Yutaka Tokuda; Yasuhiro Fujiwara; Hironobu Minami; Yasuo Ohashi; Nagahiro Saijo
Weekly epoetin beta maintains haemoglobin levels and improves quality of life in patients with non-myeloid malignancies receiving chemotherapy.
Japanese journal of clinical oncology 2008;38(3):214-21.
2008: Hideo Kunitoh; Harubumi Kato; Masahiro Tsuboi; Taro Shibata; Hisao Asamura; Yukito Ichonose; Nobuyuki Katakami; Kanji Nagai; Tetsuya Mitsudomi; Akihide Matsumura; Ken Nakagawa; Hirohito Tada; Nagahiro Saijo; Yukito Ichinose
Phase II trial of preoperative chemoradiotherapy followed by surgical resection in patients with superior sulcus non-small-cell lung cancers: report of Japan Clinical Oncology Group trial 9806.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(4):644-9.
2008: Su-Ryang Kim; Yoshiro Saito; Keiko Maekawa; Emiko Sugiyama; Nahoko Kaniwa; Hideki Ueno; Takuji Okusaka; Masafumi Ikeda; Chigusa Morizane; Noboru Yamamoto; Teruhiko Yoshida; Naoyuki Kamatani; Junji Furuse; Hiroshi Ishii; Nagahiro Saijo; Shogo Ozawa; Jun-Ichi Sawada
Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK).
Drug metabolism and pharmacokinetics 2008;23(5):379-84.
2008: Kimie Sai; Yoshiro Saito; Masaya Itoda; Hiromi Fukushima-Uesaka; Tomoko Nishimaki-Mogami; Shogo Ozawa; Keiko Maekawa; Kouichi Kurose; Nahoko Kaniwa; Manabu Kawamoto; Naoyuki Kamatani; Kuniaki Shirao; Tetsuya Hamaguchi; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Yasuhide Yamada; Tomohide Tamura; Teruhiko Yoshida; Hironobu Minami; Yasuhiro Matsumura; Atsushi Ohtsu; Nagahiro Saijo; Jun-ichi Sawada
Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population.
Drug metabolism and pharmacokinetics 2008;23(2):139-47.
2008: Heather A Wakelee; Corey Langer; Everett Vokes; Joan Schiller; Paul Baas; Nagahiro Saijo; Alex A. Adjei; Frances Shepherd; Hak Choy; David R Gandara
Cooperative group research efforts in lung cancer: focus on early-stage non-small-cell lung cancer.
Clinical lung cancer 2008;9(1):9-15.
2008: Ikuo Sekine; Minako Sumi; Nagahiro Saijo
Local control of regional and metastatic lesions and indication for systemic chemotherapy in patients with non-small cell lung cancer.
The oncologist 2008;13 Suppl 1():21-7.
2007: Maho Ukaji; Yoshiro Saito; Hiromi Fukushima-Uesaka; Keiko Maekawa; Noriko Katori; Nahoko Kaniwa; Teruhiko Yoshida; Hiroshi Nokihara; Ikuo Sekine; Hideo Kunitoh; Yuichiro Ohe; Noboru Yamamoto; Tomohide Tamura; Nagahiro Saijo; Jun-ichi Sawada
Genetic variations of VDR/NR1I1 encoding vitamin D receptor in a Japanese population.
Drug metabolism and pharmacokinetics 2007;22(6):462-7.
2007: Su-Ryang Kim; Yoshiro Saito; Kimie Sai; Kouichi Kurose; Keiko Maekawa; Nahoko Kaniwa; Shogo Ozawa; Naoyuki Kamatani; Kuniaki Shirao; Noboru Yamamoto; Tetsuya Hamaguchi; Hideo Kunitoh; Yuichiro Ohe; Yasuhide Yamada; Tomohide Tamura; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Nagahiro Saijo; Jun-ichi Sawada
Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B1*17 is more prevalent than *15.
Drug metabolism and pharmacokinetics 2007;22(6):456-61.
2007: Kimihide Yoshida; Takahiko Sugiura; Nobuhide Takifuji; Masaaki Kawahara; Kaoru Matsui; Shinzoh Kudoh; Minoru Takada; Masahiro Fukuoka; Yutaka Ariyoshi; Haruhiko Fukuda; Nagahiro Saijo
Randomized phase II trial of three intrapleural therapy regimens for the management of malignant pleural effusion in previously untreated non-small cell lung cancer: JCOG 9515.
Lung cancer (Amsterdam, Netherlands) 2007;58(3):362-8.
2007: Su-Ryang Kim; Kimie Sai; Toshiko Tanaka-Kagawa; Hideto Jinno; Shogo Ozawa; Nahoko Kaniwa; Yoshiro Saito; Akira Akasawa; Kenji Matsumoto; Hirohisa Saito; Naoyuki Kamatani; Kuniaki Shirao; Noboru Yamamoto; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Nagahiro Saijo; Jun-ichi Sawada
Haplotypes and a novel defective allele of CES2 found in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1865-72.
2007: Kiyotaka Yoh; Kaoru Kubota; Ryutaro Kakinuma; Hironobu Ohmatsu; Koichi Goto; Seiji Niho; Nagahiro Saijo; Yutaka Nishiwaki
Phase II trial of carboplatin and paclitaxel in non-small cell lung cancer patients previously treated with chemotherapy.
Lung cancer (Amsterdam, Netherlands) 2007;58(1):73-9.
2007: Ikuo Sekine; Hiroshi Nokihara; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Nagahiro Saijo; Tomohide Tamura
Problems with registration-directed clinical trials for lung cancer in Japan.
The Tohoku journal of experimental medicine 2007;213(1):17-23.
2007: Kazuko Sakai; Hideyuki Yokote; Kimiko Murakami-Murofushi; Tomohide Tamura; Nagahiro Saijo; Kazuto Nishio
Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway.
Cancer science 2007;98(9):1498-503.
2007: Seiji Niho; Hirofumi Fujii; Koji Murakami; Seisuke Nagase; Kiyotaka Yoh; Koichi Goto; Hironobu Ohmatsu; Kaoru Kubota; Ryuzo Sekiguchi; Shigeru Nawano; Nagahiro Saijo; Yutaka Nishiwaki
Detection of unsuspected distant metastases and/or regional nodes by FDG-PET [corrected] scan in apparent limited-disease small-cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2007;57(3):328-33.
2007: Takamichi Hosaka; Fumiko Inoue; Koichi Ando; Hiroo Ishida; Sojiro Kusumoto; Tomohide Sugiyama; Takao Shirai; Kentaro Okuda; Takashi Hirose; Tsukasa Ohnishi; Naoya Horichi; Nagahiro Saijo; Mitsuru Adachi; Toshio Nakadate; Toshio Kuroki; Tohru Ohmori
Mutant epidermal growth factor receptor undergoes less protein degradation due to diminished binding to c-Cbl.
Anticancer research 2007;27(4B):2253-63.
2007: Hironobu Minami; Kimie Sai; Mayumi Saeki; Yoshiro Saito; Shogo Ozawa; Kazuhiro Suzuki; Nahoko Kaniwa; Jun-ichi Sawada; Tetsuya Hamaguchi; Noboru Yamamoto; Kuniaki Shirao; Yasuhide Yamada; Hironobu Ohmatsu; Kaoru Kubota; Teruhiko Yoshida; Atsushi Ohtsu; Nagahiro Saijo
Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28.
Pharmacogenetics and genomics 2007;17(7):497-504.
2007: Yoshiro Saito; Noriko Katori; Akiko Soyama; Yukiko Nakajima; Takashi Yoshitani; Su-Ryang Kim; Hiromi Fukushima-Uesaka; Kouichi Kurose; Nahoko Kaniwa; Shogo Ozawa; Naoyuki Kamatani; Kazuo Komamura; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kenji Sugai; Narihiro Minami; Hideo Kimura; Yu-ichi Goto; Hironobu Minami; Teruhiko Yoshida; Hideo Kunitoh; Yuichiro Ohe; Noboru Yamamoto; Tomohide Tamura; Nagahiro Saijo; Jun-ichi Sawada
CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population.
Pharmacogenetics and genomics 2007;17(7):461-71.
2007: Masayuki Takeda; Tokuzo Arao; Hideyuki Yokote; Teruo Komatsu; Kazuyoshi Yanagihara; Hiroki Sasaki; Yasuhide Yamada; Tomohide Tamura; Kazuya Fukuoka; Hiroshi Kimura; Nagahiro Saijo; Kazuto Nishio
AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):3051-7.
2007: Ikuo Sekine; John D Minna; Kazuto Nishio; Nagahiro Saijo; Tomohide Tamura
Genes regulating the sensitivity of solid tumor cell lines to cytotoxic agents: a literature review.
Japanese journal of clinical oncology 2007;37(5):329-36.
2007: Kiyotaka Yoh; Seiji Niho; Koichi Goto; Hironobu Ohmatsu; Kaoru Kubota; Ryutaro Kakinuma; Nagahiro Saijo; Yutaka Nishiwaki
Randomized trial of drip infusion versus bolus injection of vinorelbine for the control of local venous toxicity.
Lung cancer (Amsterdam, Netherlands) 2007;55(3):337-41.
2007: Yuichiro Ohe; Y Ohashi; K Kubota; T Tamura; K Nakagawa; S Negoro; Y Nishiwaki; Nagahiro Saijo; Y Ariyoshi; M Fukuoka
Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(2):317-23.
2007: Keiko Maekawa; Mayumi Saeki; Yoshiro Saito; Shogo Ozawa; Kouichi Kurose; Nahoko Kaniwa; Manabu Kawamoto; Naoyuki Kamatani; Ken Kato; Tetsuya Hamaguchi; Yasuhide Yamada; Kuniaki Shirao; Yasuhiro Shimada; Manabu Muto; Toshihiko Doi; Atsushi Ohtsu; Teruhiko Yoshida; Yasuhiro Matsumura; Nagahiro Saijo; Jun-ichi Sawada
Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences.
Journal of human genetics 2007;52(10):804-19.
2007: Shigenori Kadowaki; Makoto Tahara; Nagahiro Saijo
[The palliative care in the clinical oncology].
Nihon rinsho. Japanese journal of clinical medicine 2007;65(1):5-10.
2007: Emiko Sugiyama; Nahoko Kaniwa; Su-Ryang Kim; Ruri Kikura-Hanajiri; Ryuichi Hasegawa; Keiko Maekawa; Yoshiro Saito; Shogo Ozawa; Jun-ichi Sawada; Naoyuki Kamatani; Junji Furuse; Hiroshi Ishii; Teruhiko Yoshida; Hideki Ueno; Takuji Okusaka; Nagahiro Saijo
Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(1):32-42.
2006: Su-Ryang Kim; Shogo Ozawa; Yoshiro Saito; Kouichi Kurose; Nahoko Kaniwa; Naoyuki Kamatani; Tetsuya Hamaguchi; Kuniaki Shirao; Manabu Muto; Atsushi Ohtsu; Teruhiko Yoshida; Yasuhiro Matsumura; Nagahiro Saijo; Jun-ichi Sawada
Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS).
Drug metabolism and pharmacokinetics 2006;21(6):509-16.
2006: Marie Wislez; David G Beer; Ignacio Wistuba; Jacques Cadranel; Nagahiro Saijo; Bruce E Johnson
Molecular biology, genomics, and proteomics in bronchioloalveolar carcinoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(9 Suppl):S8-12.
2006: Tomohide Tamura; Hironobu Minami; Yasuhide Yamada; Noboru Yamamoto; Tatsu Shimoyama; Haruyasu Murakami; Atsushi Horiike; Yasuhito Fujisaka; Tetsu Shinkai; Makoto Tahara; Kenji Kawada; Hiromichi Ebi; Yasutsuna Sasaki; Haiyi Jiang; Nagahiro Saijo
A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(9):1002-9.
2006: Takamoto Saijo; Genichiro Ishii; Atsushi Ochiai; Kiyotaka Yoh; Koichi Goto; Kanji Nagai; Harubumi Kato; Yutaka Nishiwaki; Nagahiro Saijo
Eg5 expression is closely correlated with the response of advanced non-small cell lung cancer to antimitotic agents combined with platinum chemotherapy.
Lung cancer (Amsterdam, Netherlands) 2006;54(2):217-25.
2006: Ikuo Sekine; Hiroshi Nokihara; Minako Sumi; Nagahiro Saijo; Yutaka Nishiwaki; Satoshi Ishikura; Kiyoshi Mori; Iwao Tsukiyama; Tomohide Tamura
Docetaxel consolidation therapy following cisplatin, vinorelbine, and concurrent thoracic radiotherapy in patients with unresectable stage III non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(8):810-5.
2006: Yasuo Morishima; Michinori Ogura; Shuichi Yoneda; Hiroshi Sakai; Kensei Tobinai; Yutaka Nishiwaki; Hironobu Minami; Tomomitsu Hotta; Kohji Ezaki; Yuichiro Ohe; Akira Yokoyama; Masahiro Tsuboi; Kiyoshi Mori; Koshiro Watanabe; Yasuo Ohashi; Kunitake Hirashima; Nagahiro Saijo
Once-weekly epoetin-beta improves hemoglobin levels in cancer patients with chemotherapy-induced anemia: A randomized, double-blind, dose-finding study.
Japanese journal of clinical oncology 2006;36(10):655-61.
2006: Kimie Sai; Masaya Itoda; Yoshiro Saito; Kouichi Kurose; Noriko Katori; Nahoko Kaniwa; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Hitonobu Tomoike; Shiro Kamakura; Masafumi Kitakaze; Toru Tamura; Noboru Yamamoto; Hideo Kunitoh; Yasuhide Yamada; Yuichiro Ohe; Yasuhiro Shimada; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Genetic variations and haplotype structures of the ABCB1 gene in a Japanese population: an expanded haplotype block covering the distal promoter region, and associated ethnic differences.
Annals of human genetics 2006;70(Pt 5):605-22.
2006: Yasuhito Fujisaka; Tomohide Tamura; Yuichiro Ohe; Hideo Kunitoh; Ikuo Sekine; Noboru Yamamoto; Hiroshi Nokihara; Atsushi Horiike; Tetsuro Kodama; Nagahiro Saijo
Pharmacokinetics and pharmacodynamics of weekly epoetin beta in lung cancer patients.
Japanese journal of clinical oncology 2006;36(8):477-82.
2006: Yukiko Nakajima; Takashi Yoshitani; Hiromi Fukushima-Uesaka; Yoshiro Saito; Nahoko Kaniwa; Kouichi Kurose; Shogo Ozawa; Nobuo Aoyagi; Naoyuki Kamatani; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Tomohide Tamura; Teruhiko Yoshida; Hironobu Minami; Nagahiro Saijo; Noriko Katori; Jun-ichi Sawada
Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer.
Clinical pharmacology and therapeutics 2006;80(2):179-91.
2006: Ikuo Sekine; Hiroshi Nokihara; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Nagahiro Saijo; Tomohide Tamura
Common arm analysis: one approach to develop the basis for global standardization in clinical trials of non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2006;53(2):157-64.
2006: Kazuko Sakai; Hideyuki Yokote; Kimiko Murakami-Murofushi; Tomohide Tamura; Nagahiro Saijo; Kazuto Nishio
In-frame deletion in the EGF receptor alters kinase inhibition by gefitinib.
The Biochemical journal 2006;397(3):537-43.
2006: Ikuo Sekine; Minako Sumi; Yoshinori Ito; Hiroshi Nokihara; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Tetsuro Kodama; Nagahiro Saijo; Tomohide Tamura
Retrospective analysis of steroid therapy for radiation-induced lung injury in lung cancer patients.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2006;80(1):93-7.
2006: Tatsu Shimoyama; Fumiaki Koizumi; Hisao Fukumoto; Katsuyuki Kiura; Mitsune Tanimoto; Nagahiro Saijo; Kazuto Nishio
Effects of different combinations of gefitinib and irinotecan in lung cancer cell lines expressing wild or deletional EGFR.
Lung cancer (Amsterdam, Netherlands) 2006;53(1):13-21.
2006: Su-Ryang Kim; Yoshiro Saito; Keiko Maekawa; Emiko Sugiyama; Nahoko Kaniwa; Hideki Ueno; Takuji Okusaka; Chigusa Morizane; Noboru Yamamoto; Masafumi Ikeda; Teruhiko Yoshida; Hironobu Minami; Junji Furuse; Hiroshi Ishii; Nagahiro Saijo; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleoside transporter 1 (hENT1).
Drug metabolism and pharmacokinetics 2006;21(3):248-56.
2006: Nagahiro Saijo
Recent trends in the treatment of advanced lung cancer.
Cancer science 2006;97(6):448-52.
2006: Atsushi Ohtsu; Shigeaki Yoshida; Nagahiro Saijo
Disparities in gastric cancer chemotherapy between the East and West.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(14):2188-96.
2006: Olufunmilayo I Olopade; Gilberto Schwartsmann; Nagahiro Saijo; Charles Thomas
Disparities in cancer care: a worldwide perspective and roadmap for change.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(14):2135-6.
2006: Seiji Niho; Koichi Goto; Kiyotaka Yoh; Young-Hak Kim; Hironobu Ohmatsu; Kaoru Kubota; Nagahiro Saijo; Yutaka Nishiwaki
Interstitial shadow on chest CT is associated with the onset of interstitial lung disease caused by chemotherapeutic drugs.
Japanese journal of clinical oncology 2006;36(5):269-73.
2006: Keiko Maekawa; Masaya Itoda; Kimie Sai; Yoshiro Saito; Nahoko Kaniwa; Kuniaki Shirao; Tetsuya Hamaguchi; Hideo Kunitoh; Noboru Yamamoto; Tomohide Tamura; Hironobu Minami; Kaoru Kubota; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population.
Drug metabolism and pharmacokinetics 2006;21(2):109-21.
2006: Hirokazu Watanabe; Hideo Kunitoh; Seiichiro Yamamoto; Shin Kawasaki; Akira Inoue; Katsuyuki Hotta; Kazu Shiomi; Masahiko Kusumoto; Kazuro Sugimura; Nagahiro Saijo
Effect of the introduction of minimum lesion size on interobserver reproducibility using RECIST guidelines in non-small cell lung cancer patients.
Cancer science 2006;97(3):214-8.
2006: Martin J Edelman; Ikuo Sekine; Tomohide Tamura; Nagahiro Saijo
Geographic variation in the second-line treatment of non-small cell lung cancer.
Seminars in oncology 2006;33(1 Suppl 1):S39-44.
2006: Kazuko Sakai; Tokuzo Arao; Tatsu Shimoyama; Kimiko Murofushi; Masaru Sekijima; Naoko Kaji; Tomohide Tamura; Nagahiro Saijo; Kazuto Nishio
Dimerization and the signal transduction pathway of a small in-frame deletion in the epidermal growth factor receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(2):311-3.
2006: Ikuo Sekine; John D Minna; Kazuto Nishio; Tomohide Tamura; Nagahiro Saijo
A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(1):31-7.
2006: Seiji Niho; Kaoru Kubota; Koichi Goto; Kiyotaka Yoh; Hironobu Ohmatsu; Ryutaro Kakinuma; Nagahiro Saijo; Yutaka Nishiwaki
First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer: a phase II study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(1):64-9.
2006: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Kimie Sai; Shogo Ozawa; Kouichi Kurose; Nahoko Kaniwa; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kuniaki Shirao; Toru Tamura; Noboru Yamamoto; Hideo Kunitoh; Tetsuya Hamaguchi; Teruhiko Yoshida; Kaoru Kubota; Atsushi Ohtsu; M Muto; Hironobu Minami; Nagahiro Saijo; Naoyuki Kamatani; Jun-ichi Sawada
Haplotype structures of the UGT1A gene complex in a Japanese population.
The pharmacogenomics journal 2006;6(1):63-75.
2005: Koichi Ando; Tohru Ohmori; Fumiko Inoue; Tsuyoki Kadofuku; Takamichi Hosaka; Hiroo Ishida; Takao Shirai; Kentaro Okuda; Takashi Hirose; Naoya Horichi; Kazuto Nishio; Nagahiro Saijo; Mitsuru Adachi; Toshio Kuroki
Enhancement of sensitivity to tumor necrosis factor alpha in non-small cell lung cancer cells with acquired resistance to gefitinib.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(24 Pt 1):8872-9.
2005: Katsuyuki Kiura; Nagahiro Saijo
Can dose-dense chemotherapy improve outcome in patients with better-prognosis small-cell lung cancer?
Nature clinical practice. Oncology 2005;2(12):610-1.
2005: Kazuto Nishio; Tokuzo Arao; Tatsu Shimoyama; Yasuhiro Fujiwara; Tomohide Tamura; Nagahiro Saijo
Translational studies for target-based drugs.
Cancer chemotherapy and pharmacology 2005;56 Suppl 1():90-3.
2005: Nagahiro Saijo
Is radiotherapy optimally combined with chemotherapy in elderly patients with limited-stage small-cell lung cancer?
Nature clinical practice. Oncology 2005;2(11):550-1.
2005: Hideyuki Akaza; Takashi Tsuruo; Nagahiro Saijo; Saburo Sone; Seiji Isonishi; Yasuo Ohashi; Shinzaburo Noguchi; Junichi Kurebayashi; Yoshiyuki Kakehi; Hideki Ishikawa; George Blackledge
[Cancer prevention].
Gan to kagaku ryoho. Cancer & chemotherapy 2005;32(10):1499-506.
2005: Takashi Kubo; Su-Ryang Kim; Kimie Sai; Yoshiro Saito; Toshiharu Nakajima; Kenji Matsumoto; Hirohisa Saito; Kuniaki Shirao; Noboru Yamamoto; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Yasuo Ohno; Shogo Ozawa; Jun-ichi Sawada
Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2).
Drug metabolism and disposition: the biological fate of chemicals 2005;33(10):1482-7.
2005: Shinobu Ikeda; Kouichi Kurose; Hideto Jinno; Kimie Sai; Shogo Ozawa; Ryuichi Hasegawa; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Tomohide Tamura; Noboru Yamamoto; Hideo Kunitoh; Yasuhide Yamada; Yuichiro Ohe; Yasuhiro Shimada; Kuniaki Shirao; Kaoru Kubota; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Yoshiro Saito; Jun-ichi Sawada
Functional analysis of four naturally occurring variants of human constitutive androstane receptor.
Molecular genetics and metabolism 2005;86(1-2):314-9.
2005: Fumiaki Koizumi; Tatsu Shimoyama; Fumiko Taguchi; Nagahiro Saijo; Kazuto Nishio
Establishment of a human non-small cell lung cancer cell line resistant to gefitinib.
International journal of cancer. Journal international du cancer 2005;116(1):36-44.
2005: Kaoru Kubota; Yutaka Nishiwaki; Takahiko Sugiura; Kazumasa Noda; Kiyoshi Mori; Masaaki Kawahara; Shunichi Negoro; Koshiro Watanabe; Fumio Imamura; Tomohide Tamura; Nagahiro Saijo
Pilot study of concurrent etoposide and cisplatin plus accelerated hyperfractionated thoracic radiotherapy followed by irinotecan and cisplatin for limited-stage small cell lung cancer: Japan Clinical Oncology Group 9903.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5534-8.
2005: Shigeo Yamazaki; Ikuo Sekine; Yoshihiro Matsuno; Hidefumi Takei; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Tomohide Tamura; Tetsuro Kodama; Hisao Asamura; Ryosuke Tsuchiya; Nagahiro Saijo
Clinical responses of large cell neuroendocrine carcinoma of the lung to cisplatin-based chemotherapy.
Lung cancer (Amsterdam, Netherlands) 2005;49(2):217-23.
2005: Satoru Koyano; Yoshiro Saito; Hiromi Fukushima-Uesaka; Seiichi Ishida; Shogo Ozawa; Naoyuki Kamatani; Hironobu Minami; Atsushi Ohtsu; Tetsuya Hamaguchi; Kuniaki Shirao; Teruhiko Yoshida; Nagahiro Saijo; Hideto Jinno; Jun-ichi Sawada
Functional analysis of six human aryl hydrocarbon receptor variants in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1254-60.
2005: Nagahiro Saijo
What phase III trials are needed to improve the treatment of advanced non-small-cell lung cancer?
Nature clinical practice. Oncology 2005;2(6):275.
2005: Nagahiro Saijo; Yuji Nimura
Summary of the ASCO-JSCO joint symposium.
International journal of clinical oncology 2005;10(3):153-6.
2005: Hiroyuki Hichiya; Toshiko Tanaka-Kagawa; Akiko Soyama; Hideto Jinno; Satoru Koyano; Noriko Katori; Erika Matsushima; Shigehisa Uchiyama; Hiroshi Tokunaga; Hideo Kimura; Narihiro Minami; Masaaki Katoh; Kenji Sugai; Yu-ichi Goto; Tomohide Tamura; Noboru Yamamoto; Yuichiro Ohe; Hideo Kunitoh; Hiroshi Nokihara; Teruhiko Yoshida; Hironobu Minami; Nagahiro Saijo; Masanori Ando; Shogo Ozawa; Yoshiro Saito; Jun-ichi Sawada
Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(5):630-6.
2005: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Kimie Sai; Akiko Hachisuka; Nahoko Kaniwa; Shogo Ozawa; Manabu Kawamoto; Naoyuki Kamatani; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Jun-ichi Sawada
Genetic variations and haplotypes of UGT1A4 in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(2):144-51.
2005: Shinji Atagi; Masaaki Kawahara; Tomohide Tamura; Kazumasa Noda; Koshiro Watanabe; Akira Yokoyama; Takahiko Sugiura; Hiroshi Senba; Satoshi Ishikura; Hiroshi Ikeda; Naoki Ishizuka; Nagahiro Saijo
Standard thoracic radiotherapy with or without concurrent daily low-dose carboplatin in elderly patients with locally advanced non-small cell lung cancer: a phase III trial of the Japan Clinical Oncology Group (JCOG9812).
Japanese journal of clinical oncology 2005;35(4):195-201.
2005: Kan Yonemori; Hideki Ueno; Takuji Okusaka; Noboru Yamamoto; Masafumi Ikeda; Nagahiro Saijo; Teruhiko Yoshida; Hiroshi Ishii; Junji Furuse; Emiko Sugiyama; Su-Ryang Kim; Ruri Kikura-Hanajiri; Ryuichi Hasegawa; Yoshiro Saito; Shogo Ozawa; Nahoko Kaniwa; Jun-ichi Sawada
Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2620-4.
2005: Yuichiro Ohe; S Negoro; K Matsui; K Nakagawa; T Sugiura; Y Takada; Y Nishiwaki; S Yokota; M Kawahara; Nagahiro Saijo; M Fukuoka; Y Ariyoshi
Phase I-II study of amrubicin and cisplatin in previously untreated patients with extensive-stage small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16(3):430-6.
2005: Noboru Yamamoto; Tomohide Tamura; Haruyasu Murakami; Tatsu Shimoyama; Hiroshi Nokihara; Yutaka Ueda; Ikuo Sekine; Hideo Kunitoh; Yuichiro Ohe; Tetsuro Kodama; Mikiko Shimizu; Kazuto Nishio; Naoki Ishizuka; Nagahiro Saijo
Randomized pharmacokinetic and pharmacodynamic study of docetaxel: dosing based on body-surface area compared with individualized dosing based on cytochrome P450 activity estimated using a urinary metabolite of exogenous cortisol.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(6):1061-9.
2005: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Kimie Sai; Nahoko Kaniwa; Shogo Ozawa; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Naoyuki Kamatani; Jun-ichi Sawada
Genetic polymorphisms of UGT1A6 in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(1):85-90.
2005: Satoru Koyano; Yoshiro Saito; Kimie Sai; Kouichi Kurose; Shogo Ozawa; Toshiharu Nakajima; Kenji Matsumoto; Hirohisa Saito; Kuniaki Shirao; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Nagahiro Saijo; Jun-ichi Sawada
Novel genetic polymorphisms in the NR3C1 (glucocorticoid receptor) gene in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(1):79-84.
2005: Atsushi Horiike; Nagahiro Saijo
Small-cell lung cancer: current therapy and novel agents.
Oncology (Williston Park, N.Y.) 2005;19(1):47-52; discussion 52, 54-8.
2005: Hideyuki Akaza; Takashi Tsuruo; Nagahiro Saijo; Saburo Sone; Seiji Isonishi; Yasuo Ohashi; Tomotaka Sobue; Hidetoshi Yamanaka; Mamoru Fukuda; Masakazu Maruyama; Kenji Eguchi; Kazuto Ito; Mark Smith; Bob Milsted
[Cancer screening].
Gan to kagaku ryoho. Cancer & chemotherapy 2005;32(1):125-34.
2004: Tokuzo Arao; Hisao Fukumoto; Masayuki Takeda; Tomohide Tamura; Nagahiro Saijo; Kazuto Nishio
Small in-frame deletion in the epidermal growth factor receptor as a target for ZD6474.
Cancer research 2004;64(24):9101-4.
2004: Fumiko Taguchi; Yasuhiro Koh; Fumiaki Koizumi; Tomohide Tamura; Nagahiro Saijo; Kazuto Nishio
Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib ("Iressa")-sensitive and resistant xenograft models.
Cancer science 2004;95(12):984-9.
2004: Nagahiro Saijo
What are the reasons for negative phase III trials of molecular-target-based drugs?
Cancer science 2004;95(10):772-6.
2004: Jong-Kook Park; Sang Hak Lee; Jin-Hyoung Kang; Kazuto Nishio; Nagahiro Saijo; Hyo-Jeong Kuh
Synergistic interaction between gefitinib (Iressa, ZD1839) and paclitaxel against human gastric carcinoma cells.
Anti-cancer drugs 2004;15(8):809-18.
2004: Koichi Goto; Ikuo Sekine; Yutaka Nishiwaki; Ryutaro Kakinuma; Kaoru Kubota; Taketoshi Matsumoto; Hironobu Ohmatsu; Seiji Niho; Tetsuro Kodama; T Shinkai; T Tamura; Y Ohe; Hideo Kunitoh; N Yamamoto; Hiroshi Nokihara; K Yoshida; T Sugiura; K Matsui; Nagahiro Saijo
Multi-institutional phase II trial of irinotecan, cisplatin, and etoposide for sensitive relapsed small-cell lung cancer.
British journal of cancer 2004;91(4):659-65.
2004: Hiromi Fukushima-Uesaka; Kimie Sai; Keiko Maekawa; Satoru Koyano; Nahoko Kaniwa; Shogo Ozawa; Manabu Kawamoto; Naoyuki Kamatani; Kazuo Komamura; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kazuyuki Ueno; Hironobu Minami; Atsushi Ohtsu; Kuniaki Shirao; Teruhiko Yoshida; Nagahiro Saijo; Yoshiro Saito; Jun-ichi Sawada
Genetic variations of the AHR gene encoding aryl hydrocarbon receptor in a Japanese population.
Drug metabolism and pharmacokinetics 2004;19(4):320-6.
2004: Ikuo Sekine; Kazumasa Noda; Fumihiro Oshita; Kouzou Yamada; Manabu Tanaka; Kosuke Yamashita; Hiroshi Nokihara; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Tomohide Tamura; Tetsuro Kodama; Minako Sumi; Nagahiro Saijo
Phase I study of cisplatin, vinorelbine, and concurrent thoracic radiotherapy for unresectable stage III non-small cell lung cancer.
Cancer science 2004;95(8):691-5.
2004: Hironobu Minami; Yuichi Ohe; Seiji Niho; Koichi Goto; Hironobu Ohmatsu; Kaoru Kubota; Ryutaro Kakinuma; Yutaka Nishiwaki; Hiroshi Nokihara; Ikuo Sekine; Nagahiro Saijo; Kazuhiko Hanada; Hiroyasu Ogata
Comparison of pharmacokinetics and pharmacodynamics of docetaxel and Cisplatin in elderly and non-elderly patients: why is toxicity increased in elderly patients?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(14):2901-8.
2004: Yasuhito Fujisaka; Nagahiro Saijo
[International estimation of molecular target drug].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(7):1225-31.
2004: Toshimi Takano; Yuichiro Ohe; Masahiko Kusumoto; Ukihide Tateishi; Seiichiro Yamamoto; Hiroshi Nokihara; Noboru Yamamoto; Ikuo Sekine; Hideo Kunitoh; Tomohide Tamura; Tetsuro Kodama; Nagahiro Saijo
Risk factors for interstitial lung disease and predictive factors for tumor response in patients with advanced non-small cell lung cancer treated with gefitinib.
Lung cancer (Amsterdam, Netherlands) 2004;45(1):93-104.
2004: Nagahiro Saijo; Atsushi Horiike
Topoisomerase I inhibitors in small-cell lung cancer. The Japanese experience.
Oncology (Williston Park, N.Y.) 2004;18(7 Suppl 4):11-6.
2004: Kimie Sai; Mayumi Saeki; Yoshiro Saito; Shogo Ozawa; Noriko Katori; Hideto Jinno; Ryuichi Hasegawa; Nahoko Kaniwa; Jun-ichi Sawada; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Yutaka Kitamura; Naoyuki Kamatani; Hironobu Minami; Atsushi Ohtsu; Kuniaki Shirao; Teruhiko Yoshida; Nagahiro Saijo
UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer.
Clinical pharmacology and therapeutics 2004;75(6):501-15.
2004: Ikuo Sekine; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Tomohide Tamura; Tetsuro Kodama; Nagahiro Saijo
Treatment of small cell lung cancer in the elderly based on a critical literature review of clinical trials.
Cancer treatment reviews 2004;30(4):359-68.
2004: Hideyuki Akaza; Masayuki Nakagawa; Takashi Tsuruo; Nagahiro Saijo; Saburo Sone; Nobuyuki Yamamoto; Yoshihiro Kakeji; Seigo Nakamura; Junichi Kurebayashi; Seiji Isonishi; Yasuo Ohashi; George Blackledge; James Carmichael
[Anti angiogenesis].
Gan to kagaku ryoho. Cancer & chemotherapy 2004;31(4):647-55.
2004: Ikuo Sekine; Hiroshi Nokihara; Atsushi Horiike; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Tomohide Tamura; Tetsuro Kodama; Nagahiro Saijo
Phase I study of cisplatin analogue nedaplatin (254-S) and paclitaxel in patients with unresectable squamous cell carcinoma.
British journal of cancer 2004;90(6):1125-8.
2004: Fumiko Taguchi; Hitoshi Kusaba; Akira Asai; Yasuo Iwamoto; Keiichi Yano; Hirofumi Nakano; Tamio Mizukami; Nagahiro Saijo; Harubumi Kato; Kazuto Nishio
hnRNP L enhances sensitivity of the cells to KW-2189.
International journal of cancer. Journal international du cancer 2004;108(5):679-85.
2004: Fumiaki Koizumi; Fumihiko Kanzawa; Yutaka Ueda; Yasuhiro Koh; Shoji Tsukiyama; Fumiko Taguchi; Tomohide Tamura; Nagahiro Saijo; Kazuto Nishio
Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ("Iressa") and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells.
International journal of cancer. Journal international du cancer 2004;108(3):464-72.
2004: Hideyuki Akaza; Tomohiko Ichikawa; Takashi Tsuruo; Yasuhiro Shimada; Hisataka Moriwaki; Masaki Mori; Shinzaburo Noguchi; Seigo Nakamura; Nagahiro Saijo; Saburo Sone; Seiji Isonishi; Yasuo Ohashi; Shiro Hinotsu; Mikael von Euler; George Blackedge
[Molecule based diagnosis].
Gan to kagaku ryoho. Cancer & chemotherapy 2004;31(1):125-33.
2004: Yuichiro Ohe; Seiji Niho; Ryutaro Kakinuma; K Kubota; Hironobu Ohmatsu; K Goto; Hiroshi Nokihara; Hideo Kunitoh; Nagahiro Saijo; H Aono; K Watanabe; M Tango; A Yokoyama; Y Nishiwaki
A phase II study of cisplatin and docetaxel administered as three consecutive weekly infusions for advanced non-small-cell lung cancer in elderly patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(1):45-50.
2003: Nagahiro Saijo
Progress in treatment of small-cell lung cancer: role of CPT-11.
British journal of cancer 2003;89(12):2178-83.
2003: Hirokazu Watanabe; Noboru Yamamoto; Tomohide Tamura; Tatsu Shimoyama; Katsuyuki Hotta; Akira Inoue; Masahiro Sawada; Yoshiko Akiyama; Hitoshi Kusaba; Hiroshi Nokihara; Ikuo Sekine; Hideo Kunitoh; Yuichiro Ohe; Tetsuro Kodama; Nagahiro Saijo
Study of paclitaxel and dose escalation of cisplatin in patients with advanced non-small cell lung cancer.
Japanese journal of clinical oncology 2003;33(12):626-30.
2003: Kimie Sai; Nahoko Kaniwa; Masaya Itoda; Yoshiro Saito; Ryuichi Hasegawa; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Yutaka Kitamura; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan.
Pharmacogenetics 2003;13(12):741-57.
2003: Yuichi Ando; Tomoko Ohtsu; Masahiko Ando; Fumiyoshi Ohyanagi; Fumio Nagashima; Masaru Narabayashi; Nagahiro Saijo; Yasutsuna Sasaki
Re: Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001.
Journal of the National Cancer Institute 2003;95(21):1638-40.
2003: Hirokazu Watanabe; Seiichiro Yamamoto; Hideo Kunitoh; Ikuo Sekine; Noboru Yamamoto; Yuichiro Ohe; Tomohide Tamura; Tetsuro Kodama; Kazuro Sugimura; Nagahiro Saijo
Tumor response to chemotherapy: the validity and reproducibility of RECIST guidelines in NSCLC patients.
Cancer science 2003;94(11):1015-20.
2003: Toshimi Takano; Nagahiro Saijo
[Doctor-initiated clinical trials and the revised pharmaceutical affairs law].
Gan to kagaku ryoho. Cancer & chemotherapy 2003;30(10):1391-7.
2003: Yoichi Nakamura; Hideo Kunitoh; Kaoru Kubota; Ikuo Sekine; Noboru Yamamoto; Tomohide Tamura; Tetsuro Kodama; Nagahiro Saijo
Retrospective analysis of safety and efficacy of low-dose docetaxel 60 mg/m2 in advanced non-small cell lung cancer patients previously treated with platinum-based chemotherapy.
American journal of clinical oncology 2003;26(5):459-64.
2003: Ryuya Yamanaka; Shigeru Akutagawa; Fumiko Taguchi; Naoki Yajima; Naoto Tsuchiya; Takeo Uzuka; Ken Morii; Hideaki Takahashi; Ryuichi Tanaka; Nagahiro Saijo; Kazuto Nishio
Selection of surrogate marker genes in primary central nervous system lymphomas for radio-chemotherapy by DNA array analysis of gene expression profiles.
International journal of oncology 2003;23(4):913-23.
2003: Tsugitaka Natsume; Jun-ichi Watanabe; Yasuhiro Koh; Nami Fujio; Yuichiro Ohe; Toshi Horiuchi; Nagahiro Saijo; Kazuto Nishio; Motohiro Kobayashi
Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo.
Cancer science 2003;94(9):826-33.
2003: Nagahiro Saijo; Kazuto Nishio; Tomohide Tamura
Translational and clinical studies of target-based cancer therapy.
International journal of clinical oncology 2003;8(4):187-92.
2003: Yuichiro Ohe; Naoki Ishizuka; Tomohide Tamura; Ikuo Sekine; Yutaka Nishiwaki; Nagahiro Saijo
Long-term follow-up of patients with unresectable locally advanced non-small cell lung cancer treated with chemoradiotherapy: a retrospective analysis of the data from the Japan Clinical Oncology Group trials (JCOG0003A).
Cancer science 2003;94(8):729-34.
2003: Hideto Jinno; Mayumi Saeki; Yoshiro Saito; Toshiko Tanaka-Kagawa; Nobumitsu Hanioka; Kimie Sai; Nahoko Kaniwa; Masanori Ando; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Shogo Ozawa; Jun-ichi Sawada
Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients.
The Journal of pharmacology and experimental therapeutics 2003;306(2):688-93.
2003: Nagahiro Saijo; Tomohide Tamura; Kazuto Nishio
Strategy for the development of novel anticancer drugs.
Cancer chemotherapy and pharmacology 2003;52 Suppl 1():S97-101.
2003: Tatsuhiko Tsunoda; Yasuhiro Koh; Fumiaki Koizumi; Shoji Tsukiyama; Hiroshi Ueda; Fumiko Taguchi; Hiroki Yamaue; Nagahiro Saijo; Kazuto Nishio
Differential gene expression profiles and identification of the genes relevant to clinicopathologic factors in colorectal cancer selected by cDNA array method in combination with principal component analysis.
International journal of oncology 2003;23(1):49-59.
2003: Toshio Shimizu; Nagahiro Saijo
[Common toxicity criteria: version 2.0, an improved reference for grading the adverse reaction of cancer treatment].
Nihon rinsho. Japanese journal of clinical medicine 2003;61(6):937-42.
2003: Fumihiko Kanzawa; Y Akiyama; Nagahiro Saijo; Kazuto Nishio
In vitro effects of combinations of cis-amminedichloro (2-methylpyridine) platinum (II) (ZD0473) with other novel anticancer drugs on the growth of SBC-3, a human small cell lung cancer cell line.
Lung cancer (Amsterdam, Netherlands) 2003;40(3):325-32.
2003: I Sekine; Y Nishiwaki; K Noda; S Kudoh; M Fukuoka; K Mori; S Negoro; A Yokoyama; K Matsui; Y Ohsaki; T Nakano; Nagahiro Saijo
Randomized phase II study of cisplatin, irinotecan and etoposide combinations administered weekly or every 4 weeks for extensive small-cell lung cancer (JCOG9902-DI).
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2003;14(5):709-14.
2003: Hideto Jinno; Mayumi Saeki; Toshiko Tanaka-Kagawa; Nobumitsu Hanioka; Yoshiro Saito; Shogo Ozawa; Masanori Ando; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Jun-ichi Sawada
Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(5):528-32.
2003: Hideyuki Akaza; Masahiro Fukuoka; Atsushi Ohtsu; Michiyuki Usami; Tadashi Ikeda; Keisuke Aiba; Seiji Isonishi; Yasuo Ohashi; Nagahiro Saijo; Saburo Sone; Shigeru Tsukagoshi; Takashi Tsuruo; Masuhiro Kato; Osamu Mikami; Rui-Ping Dong; Mikael von Euler; George Blackledge; Don Stribling
[Globalization of clinical trials].
Gan to kagaku ryoho. Cancer & chemotherapy 2003;30(4):555-65.
2003: Ikuo Sekine; Yutaka Nishiwaki; Ryutaro Kakinuma; Kaoru Kubota; F Hojo; Taketoshi Matsumoto; Hironobu Ohmatsu; Koichi Goto; Tetsuro Kodama; K Eguchi; T Shinkai; T Tamura; Y Ohe; Hideo Kunitoh; K Yoshimura; Nagahiro Saijo
Phase I/II trial of weekly cisplatin, etoposide, and irinotecan chemotherapy for metastatic lung cancer: JCOG 9507.
British journal of cancer 2003;88(6):808-13.
2003: Shinobu Ikeda; Kouichi Kurose; Shogo Ozawa; Kimie Sai; Ryuichi Hasegawa; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Toshiharu Nakajima; Kenji Matsumoto; Hirohisa Saito; Yu-Ichi Goto; Hideo Kimura; Masaaki Katoh; Kenji Sugai; Narihiro Minami; Kuniaki Shirao; Tomohide Tamura; Noboru Yamamoto; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Yoshiro Saito; Jun-ichi Sawada
Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population.
Drug metabolism and pharmacokinetics 2003;18(6):413-8.
2003: Su-Ryang Kim; Takahiro Nakamura; Yoshiro Saito; Kimie Sai; Toshiharu Nakajima; Hirohisa Saito; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Shogo Ozawa; Jun-ichi Sawada
Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2).
Drug metabolism and pharmacokinetics 2003;18(5):327-32.
2003: Masaya Itoda; Yoshiro Saito; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Hiroshi Suzuki; Yuichi Sugiyama; Shogo Ozawa; Jun-ichi Sawada
Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.
Drug metabolism and pharmacokinetics 2003;18(3):212-7.
2003: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Kimie Sai; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Shogo Ozawa; Jun-ichi Sawada
Three novel single nucleotide polymorphisms in UGT1A9.
Drug metabolism and pharmacokinetics 2003;18(2):146-9.
2003: Jitsuo Usuda; Motoko Inomata; Hisao Fukumoto; Yasuo Iwamoto; Toshihiro Suzuki; Hyo-Jeong Kuh; Kazuya Fukuoka; Harubumi Kato; Nagahiro Saijo; Kazuto Nishio
Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells.
International journal of oncology 2003;22(1):81-6.
2002: Haruyasu Murakami; Tomohide Tamura; Yasuhide Yamada; Noboru Yamamoto; Y Ueda; Tatsu Shimoyama; Nagahiro Saijo
ZD0473 pharmacokinetics in Japanese patients: a Phase I dose-escalation study.
European journal of cancer (Oxford, England : 1990) 2002;38 Suppl 8():S1-5.
2002: Nagahiro Saijo
[Medical oncology in Japan].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2002;91(11):3143-6.
2002: Hideyuki Akaza; Yasuo Ohashi; Yasuhiro Shimada; Tadashi Ikeda; Nagahiro Saijo; Seiji Isonishi; Yoshihiko Hirao; Takashi Tsuruo; Shigeru Tsukagoshi; Saburo Sone; Seigo Nakamura; Masuhiro Kato; Osamu Mikami; Mikael von Euler; George Blackledge; Bob Milsted; Brent Vose
[Post launch studies].
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29(11):2037-48.
2002: Akira Inoue; Hideo Kunitoh; Kiyoshi Mori; Tohishiro Nukiwa; Masahiro Fukuoka; Nagahiro Saijo
Phase I trial of weekly docetaxel in elderly patients with non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2002;38(2):205-9.
2002: Nagahiro Saijo
Translational study in cancer research.
Internal medicine (Tokyo, Japan) 2002;41(10):770-3.
2002: Yoshiko Kawamura-Akiyama; Hitoshi Kusaba; Fumihiko Kanzawa; Tomohide Tamura; Nagahiro Saijo; Kazuto Nishio
Non-cross resistance of ZD0473 in acquired cisplatin-resistant lung cancer cell lines.
Lung cancer (Amsterdam, Netherlands) 2002;38(1):43-50.
2002: I Sekine; N Yamamoto; Hideo Kunitoh; Yuichiro Ohe; T Tamura; T Kodama; Nagahiro Saijo
Relationship between objective responses in phase I trials and potential efficacy of non-specific cytotoxic investigational new drugs.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13(8):1300-6.
2002: Minoru Takada; Masahiro Fukuoka; Masaaki Kawahara; Takahiko Sugiura; Akira Yokoyama; Soichiro Yokota; Yutaka Nishiwaki; Koshiro Watanabe; Kazumasa Noda; Tomohide Tamura; Haruhiko Fukuda; Nagahiro Saijo
Phase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small-cell lung cancer: results of the Japan Clinical Oncology Group Study 9104.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(14):3054-60.
2002: Tatsuo Ohira; Shigeru Akutagawa; Jitsuo Usuda; Takashi Nakamura; Takashi Hirano; Masahiro Tsuboi; Kazuto Nishio; Fumiko Taguchi; Norihido Ikeda; Haruhiko Nakamura; Chimori Konaka; Nagahiro Saijo; Harubumi Kato
Up-regulated gene expression of angiogenesis factors in post-chemotherapeutic lung cancer tissues determined by cDNA macroarray.
Oncology reports 2002;9(4):723-8.
2002: Yuichiro Ohe; Nagahiro Saijo
Results of recent Japanese clinical trials in lung cancer.
Clinical lung cancer 2002;3(4):243-8.
2002: Yasuhito Fujisaka; Nagahiro Saijo
[Growth factor induced signal transduction in lung cancer].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 5():83-8.
2002: Yukiko Kishi; Nagahiro Saijo
[Strategy of therapy for lung cancer].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 5():305-8.
2002: Ichiro Naruse; Hisao Fukumoto; Nagahiro Saijo; Kazuto Nishio
Enhanced anti-tumor effect of trastuzumab in combination with cisplatin.
Japanese journal of cancer research : Gann 2002;93(5):574-81.
2002: Kazuya Fukuoka; Hitoshi Arioka; Yasuo Iwamoto; Hisao Fukumoto; Hirokazu Kurokawa; Tomoyuki Ishida; Akira Tomonari; Toshihiro Suzuki; Jitsuo Usuda; Fumihiko Kanzawa; Hiroshi Kimura; Nagahiro Saijo; Kazuto Nishio
Mechanism of vinorelbine-induced radiosensitization of human small cell lung cancer cells.
Cancer chemotherapy and pharmacology 2002;49(5):385-90.
2002: Fumiyuki Takahashi; Shigeru Akutagawa; Hisao Fukumoto; Shoji Tsukiyama; Yuichiro Ohe; Kazuhisa Takahashi; Yoshinosuke Fukuchi; Nagahiro Saijo; Kazuto Nishio
Osteopontin induces angiogenesis of murine neuroblastoma cells in mice.
International journal of cancer. Journal international du cancer 2002;98(5):707-12.
2002: Ichiro Naruse; Tohru Ohmori; Yoko Ao; Hisao Fukumoto; Toshio Kuroki; Masatomo Mori; Nagahiro Saijo; Kazuto Nishio
Antitumor activity of the selective epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) Iressa (ZD1839) in an EGFR-expressing multidrug-resistant cell line in vitro and in vivo.
International journal of cancer. Journal international du cancer 2002;98(2):310-5.
2002: Yasuhiro Koh; Tatsuhiko Tsunoda; Makoto Iwahashi; Hiroki Yamaue; Kiwao Ishimoto; Hiroshi Tanimura; Hisao Fukumoto; Takashi Nakamura; Yasuaki Tatsumi; Mikiko Shimizu; Nagahiro Saijo; Kazuto Nishio
Decreased expression of alpha2,8 sialyltransferase and increased expression of beta1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers.
Experimental biology and medicine (Maywood, N.J.) 2002;227(3):196-200.
2002: Hitoshi Kusaba; Tomohide Tamura; Tatsu Shimoyama; Katsuyuki Hotta; Akira Inoue; Hiroshi Nokihara; Yutaka Ueda; Yoshiko Akiyama; Noboru Yamamoto; Ikuo Sekine; Hideo Kunitoh; Yuichiro Ohe; Tetsuro Kodama; Nagahiro Saijo
Phase I/II study of 3-week cycle cisplatin-gemcitabine in advanced non-small cell lung cancer.
Japanese journal of clinical oncology 2002;32(2):43-7.
2002: Yasufumi Kato; Nagahiro Saijo
[Developed new agents for lung cancer].
Nihon Geka Gakkai zasshi 2002;103(2):218-23.
2002: Hideyuki Akaza; Keisuke Aiba; Seiji Isonishi; Tadashi Ikeda; Yasuo Ohashi; Koji Kawai; Nagahiro Saijo; Toshiaki Saeki; Saburo Sone; Shigeru Tsukagoshi; Takashi Tsuruo; Narikazu Boku; Masuhiro Kato; Osamu Mikami; George Blackledge; Don Stribling
[Globalization of anti-cancer therapies].
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29(2):205-14.
2002: Ikuo Sekine; Yutaka Nishiwaki; Takashi Ogino; Akira Yokoyama; Mari Saito; Kiyoshi Mori; Iwao Tsukiyama; Satoshi Tsuchiya; Kazushige Hayakawa; Kimio Yoshimura; Naoki Ishizuka; Nagahiro Saijo
Phase II study of twice-daily high-dose thoracic radiotherapy alternating with cisplatin and vindesine for unresectable stage III non-small-cell lung cancer: Japan Clinical Oncology Group Study 9306.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(3):797-803.
2002: Kazumasa Noda; Yutaka Nishiwaki; Masaaki Kawahara; Shunichi Negoro; Takahiko Sugiura; Akira Yokoyama; Masahiro Fukuoka; Kiyoshi Mori; Koshiro Watanabe; Tomohide Tamura; Seiichiro Yamamoto; Nagahiro Saijo
Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer.
The New England journal of medicine 2002;346(2):85-91.
2002: Mayumi Saeki; Shogo Ozawa; Yoshiro Saito; Hideto Jinno; Tetsuya Hamaguchi; Hiroshi Nokihara; Yasuhiro Shimada; Hideo Kunitoh; Noboru Yamamoto; Yuichiro Ohe; Yasuhide Yamada; Kuniaki Shirao; Manabu Muto; Kiyomi Mera; Koichi Goto; Hironobu Ohmatsu; Kaoru Kubota; Seiji Niho; Ryutaro Kakinuma; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Jun-ichi Sawada
Three novel single nucleotide polymorphisms in UGT1A10.
Drug metabolism and pharmacokinetics 2002;17(5):488-90.
2002: Keiichi Yoshino; Y Takahashi; Toshifusa Nakajima; Shigeaki Yoshida; Nagahiro Saijo; Yoshihiko Maehara; Yu Sakata; Hisakazu Yamagishi; Kimiya Takeshita; Hiroyuki Ono; Yuko Kitagawa; Seigo Kitano
Meeting report of the 74th Congress of the Japanese Gastric Cancer Association.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2002;5(4):185-93.
2002: Tsugitaka Natsume; Yasuhiro Koh; Motohiro Kobayashi; Hisao Fukumoto; Fumiyuki Takahashi; Takashi Nakamura; Yuichiro Ohe; Nagahiro Saijo; Kazuto Nishio
Enhanced antitumor activities of TZT-1027 against TNF-alpha or IL-6 secreting Lewis lung carcinoma in vivo.
Cancer chemotherapy and pharmacology 2002;49(1):35-47.
2001: Katsuyuki Hotta; Ikuo Sekine; Tomohide Tamura; Masahiro Sawada; H Watanabe; Hitoshi Kusaba; Yoshiko Akiyama; Akira Inoue; Tatsu Shimoyama; Hiroshi Nokihara; Yutaka Ueda; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Tetsuro Kodama; Nagahiro Saijo
A phase I/II study of cisplatin and vinorelbine chemotherapy in patients with advanced non-small cell lung cancer.
Japanese journal of clinical oncology 2001;31(12):596-600.
2001: Kazuya Fukuoka; Hitoshi Arioka; Yasuo Iwamoto; Hisao Fukumoto; Hirokazu Kurokawa; Tomoyuki Ishida; Akira Tomonari; Toshihiro Suzuki; Jitsuo Usuda; Fumihiko Kanzawa; Nagahiro Saijo; Kazuto Nishio
Mechanism of the radiosensitization induced by vinorelbine in human non-small cell lung cancer cells.
Lung cancer (Amsterdam, Netherlands) 2001;34(3):451-60.
2001: Mitsuzi Yoshida; W Feng; Kazuto Nishio; M Takahashi; Yuji Heike; Nagahiro Saijo; Hiro Wakasugi; Tetsuro Ikekawa
Antitumor action of the PKC activator gnidimacrin through cdk2 inhibition.
International journal of cancer. Journal international du cancer 2001;94(3):348-52.
2001: Yoshiko Akiyama; Yuichiro Ohe; Tomohide Tamura; Masahiro Sawada; Akira Inoue; Hitoshi Kusaba; Noboru Yamamoto; Ikuo Sekine; Hideo Kunitoh; Tetsuro Kodama; Nagahiro Saijo
A dose escalation study of paclitaxel and carboplatin in untreated Japanese patients with advanced non-small cell lung cancer.
Japanese journal of clinical oncology 2001;31(10):482-7.
2001: K Matsumoto; Nagahiro Saijo
[Issues in cancer treatments--EBM, individuation, and standardization].
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(10):1323-30.
2001: Jitsuo Usuda; Tetsuya Okunaka; Kinya Furukawa; Takaaki Tsuchida; Yukari Kuroiwa; Y Ohe; Nagahiro Saijo; Kazuto Nishio; Chimori Konaka; Harubumi Kato
Increased cytotoxic effects of photodynamic therapy in IL-6 gene transfected cells via enhanced apoptosis.
International journal of cancer. Journal international du cancer 2001;93(4):475-80.
2001: Hideo Kunitoh; Yoshiko Akiyama; Hitoshi Kusaba; Noboru Yamamoto; Ikuo Sekine; Yuichiro Ohe; K Kubota; Tomohide Tamura; T Shinkai; Tetsuro Kodama; K Goto; Seiji Niho; Y Nishiwaki; Nagahiro Saijo
A phase I/II trial of cisplatin, docetaxel and ifosfamide in advanced or recurrent non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2001;33(2-3):259-65.
2001: A Inoue; Nagahiro Saijo
Recent advances in the chemotherapy of non-small cell lung cancer.
Japanese journal of clinical oncology 2001;31(7):299-304.
2001: Y Tatsumi; Hitoshi Arioka; S Ikeda; Hisao Fukumoto; K Miyamoto; Kazuya Fukuoka; Yuichiro Ohe; Nagahiro Saijo; Kazuto Nishio
Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6.
Japanese journal of cancer research : Gann 2001;92(7):768-77.
2001: T Nakamura; Fumiaki Koizumi; N Kaneko; Tomohide Tamura; F Chiwaki; Yasuhiro Koh; Shigeru Akutagawa; Nagahiro Saijo; Kazuto Nishio
Reversal of cisplatin resistance by the 1,4-benzothiazepine derivative, JTV-519.
Japanese journal of cancer research : Gann 2001;92(6):597-602.
2001: I Sekine; Nagahiro Saijo
Growth-stimulating pathways in lung cancer: implications for targets of therapy.
Clinical lung cancer 2001;2(4):299-306; discussion 307.
2001: Hideyuki Akaza; Nagahiro Saijo; Keisuke Aiba; Seiji Isonishi; Yasuo Ohashi; Koji Kawai; T Konishi; Toshiaki Saeki; Saburo Sone; Shigeru Tsukagoshi; Takashi Tsuruo; Shinzaburo Noguchi; Tsuneharu Miki; Osamu Mikami; M Smith; G Hoctin-Boes; Don Stribling
[Platinum compounds in cancer therapy--past, present, and future].
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(5):625-35.
2001: Y Ueda; Nagahiro Saijo
[Signal transduction inhibitor].
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(5):591-600.
2001: M Shimizu; Tomohide Tamura; Y Yamada; Y Akiyama; Nagahiro Saijo; Kazuto Nishio
CPT-11 alters the circadian rhythm of dihydropyrimidine dehydrogenase mRNA in mouse liver.
Japanese journal of cancer research : Gann 2001;92(5):554-61.
2001: Kazuto Nishio; T Nakamura; Yasuhiro Koh; Fumihiko Kanzawa; Tomohide Tamura; Nagahiro Saijo
Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cells.
Cancer 2001;91(8):1494-9.
2001: Yuichiro Ohe; Seiji Niho; Ryutaro Kakinuma; Kaoru Kubota; Taketoshi Matsumoto; Hironobu Ohmatsu; Koichi Goto; Hideo Kunitoh; Nagahiro Saijo; Yutaka Nishiwaki
Phase I studies of cisplatin and docetaxel administered by three consecutive weekly infusions for advanced non-small cell lung cancer in elderly and non-elderly patients.
Japanese journal of clinical oncology 2001;31(3):100-6.
2001: Y Ohe; Nagahiro Saijo
Topoisomerase I targeting agents in small-cell lung cancer.
Current oncology reports 2001;3(2):170-8.
2001: A Inoue; Hideo Kunitoh; Ikuo Sekine; M Sumi; K Tokuuye; Nagahiro Saijo
Radiation pneumonitis in lung cancer patients: a retrospective study of risk factors and the long-term prognosis.
International journal of radiation oncology, biology, physics 2001;49(3):649-55.
2001: T Natsume; T Nakamura; Y Koh; M Kobayashi; Nagahiro Saijo; Kazuto Nishio
Gene expression profiling of exposure to TZT-1027, a novel microtubule-interfering agent, in non-small cell lung cancer PC-14 cells and astrocytes.
Investigational new drugs 2001;19(4):293-302.
2001: Kazuya Fukuoka; Jitsuo Usuda; Yasuo Iwamoto; Hisao Fukumoto; T Nakamura; T Yoneda; N Narita; Nagahiro Saijo; Kazuto Nishio
Mechanisms of action of the novel sulfonamide anticancer agent E7070 on cell cycle progression in human non-small cell lung cancer cells.
Investigational new drugs 2001;19(3):219-27.
2001: Tatsuhiko Tsunoda; T Nakamura; Kiwao Ishimoto; Hiroki Yamaue; Hiroshi Tanimura; Nagahiro Saijo; K Nishio
Upregulated expression of angiogenesis genes and down regulation of cell cycle genes in human colorectal cancer tissue determined by cDNA macroarray.
Anticancer research 2001;21(1A):137-43.
2001: Fumihiko Kanzawa; Fumiaki Koizumi; Yasuhiro Koh; T Nakamura; Y Tatsumi; Hisao Fukumoto; Nagahiro Saijo; T Yoshioka; Kazuto Nishio
In vitro synergistic interactions between the cisplatin analogue nedaplatin and the DNA topoisomerase I inhibitor irinotecan and the mechanism of this interaction.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(1):202-9.
2000: Hyo-Jeong Kuh; S Nakagawa; Jitsuo Usuda; K Yamaoka; Nagahiro Saijo; Kazuto Nishio
A computational model for quantitative analysis of cell cycle arrest and its contribution to overall growth inhibition by anticancer agents.
Japanese journal of cancer research : Gann 2000;91(12):1303-13.
2000: Kazuya Fukuoka; T Yamagishi; T Ichihara; Shiro Nakaike; K Iguchi; Y Yamada; Hisao Fukumoto; T Yoneda; Kazunori Samata; Hisao Ikeya; Kayoko Nanaumi; N Hirayama; N Narita; Nagahiro Saijo; Kazuto Nishio
Mechanism of action of aragusterol a (YTA0040), a potent anti-tumor marine steroid targeting the G(1) phase of the cell cycle.
International journal of cancer. Journal international du cancer 2000;88(5):810-9.
2000: M Fujishiro; T Shinkai; M Fukuda; Tomohide Tamura; Yuichiro Ohe; Hideo Kunitoh; Y Nishiwaki; Ikuo Sekine; H Fukuda; Nagahiro Saijo
Phase I study of a weekly infusion of irinotecan hydrochloride (CPT-11) and a 14-day continuous infusion of etoposide in patients with lung cancer: JCOG trial 9408.
Japanese journal of clinical oncology 2000;30(11):487-93.
2000: H Murakami; Y Ohe; Nagahiro Saijo
[The strategy of combination phase I/II study].
Gan to kagaku ryoho. Cancer & chemotherapy 2000;27(13):2151-4.
2000: I Sekine; Takahisa Matsuda; T Saisho; H Watanabe; Noboru Yamamoto; H Kunitoh; Y Ohe; Tomohide Tamura; T Kodama; Nagahiro Saijo
Bacterial meningitis observed in a phase I trial of vinorelbine, cisplatin and thoracic radiotherapy for non-small cell lung cancer: report of a case and discussion on dose-limiting toxicity.
Japanese journal of clinical oncology 2000;30(9):401-5.
2000: Yuichiro Ohe; Nagahiro Saijo
[The role of the Japan Clinical Oncology Group].
Gan to kagaku ryoho. Cancer & chemotherapy 2000;27(8):1127-32.
2000: Noboru Yamamoto; Tomohide Tamura; Y Kamiya; Ikuo Sekine; Hideo Kunitoh; Nagahiro Saijo
Correlation between docetaxel clearance and estimated cytochrome P450 activity by urinary metabolite of exogenous cortisol.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(11):2301-8.
2000: Kazuya Fukuoka; Kazuto Nishio; Hisao Fukumoto; Hitoshi Arioka; Hirokazu Kurokawa; Tomoyuki Ishida; Yasuo Iwamoto; Akira Tomonari; Toshihiro Suzuki; Jitsuo Usuda; N Narita; Nagahiro Saijo
Ectopic p16(ink4) expression enhances CPT-11-induced apoptosis through increased delay in S-phase progression in human non-small-cell-lung-cancer cells.
International journal of cancer. Journal international du cancer 2000;86(2):197-203.
2000: Toru Watanabe; Chikako Shimizu; Noriyuki Katsumata; Nagahiro Saijo
[Trastuzumab for treatment of advanced breast cancers].
Nihon rinsho. Japanese journal of clinical medicine 2000;58 Suppl():340-4.
2000: Toru Watanabe; Noriyuki Katsumata; Nagahiro Saijo
[Treatment guideline for advanced or recurrent breast cancer].
Nihon rinsho. Japanese journal of clinical medicine 2000;58 Suppl():237-45.
2000: Toshihiro Suzuki; H Sasaki; Hyo-Jeong Kuh; M Agui; Y Tatsumi; S Tanabe; M Terada; Nagahiro Saijo; Kazuto Nishio
Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts.
Gene 2000;242(1-2):167-73.
2000: Jitsuo Usuda; Nagahiro Saijo; Kazuya Fukuoka; Hisao Fukumoto; Hyo-Jeong Kuh; T Nakamura; Y Koh; Toshihiro Suzuki; F Koizumi; Tomohide Tamura; Harubumi Kato; Kazuto Nishio
Molecular determinants of UCN-01-induced growth inhibition in human lung cancer cells.
International journal of cancer. Journal international du cancer 2000;85(2):275-80.
2000: Y Nakamura; I Sekine; K Furuse; Nagahiro Saijo
Retrospective comparison of toxicity and efficacy in phase II trials of 3-h infusions of paclitaxel for patients 70 years of age or older and patients under 70 years of age.
Cancer chemotherapy and pharmacology 2000;46(2):114-8.
2000: Nagahiro Saijo; Tomohide Tamura; K Nishio
Problems in the development of target-based drugs.
Cancer chemotherapy and pharmacology 2000;46 Suppl():S43-5.
2000: H Watanabe; Nagahiro Saijo
[Evidence based chemotherapy for lung cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 2000;27(1):30-43.
1999: H Kunitoh; I Sekine; K Kubota; T Tamura; T Shinkai; T Kodama; Nagahiro Saijo; T Naruke; N Yamaguchi
Histologic types of lung carcinoma and related family history of anatomic sites and histologic types of cancers.
Cancer 1999;86(7):1182-8.
1999: Hisao Fukumoto; Kazuto Nishio; S Ohta; N Hanai; Kazuya Fukuoka; Yuichiro Ohe; K Sugihara; T Kodama; Nagahiro Saijo
Effect of a chimeric anti-ganglioside GM2 antibody on ganglioside GM2-expressing human solid tumors in vivo.
International journal of cancer. Journal international du cancer 1999;82(5):759-64.
1999: Kazuto Nishio; T Nakamura; Yasuhiro Koh; T Suzuki; Hisao Fukumoto; Nagahiro Saijo
Drug resistance in lung cancer.
Current opinion in oncology 1999;11(2):109-15.
1999: Kazuto Nishio; Kazuya Fukuoka; Hisao Fukumoto; T Sunami; Yasuo Iwamoto; Toshihiro Suzuki; Jitsuo Usuda; Nagahiro Saijo
Mitogen-activated protein kinase antisense oligonucleotide inhibits the growth of human lung cancer cells.
International journal of oncology 1999;14(3):461-9.
1999: Hisao Fukumoto; Tomohide Tamura; Y Kamiya; Jitsuo Usuda; Toshihiro Suzuki; Fumihiko Kanzawa; Hyo-Jeong Kuh; Y Ohe; Nagahiro Saijo; Kazuto Nishio
Activation-induced apoptosis of peripheral lymphocytes treated with 7-hydroxystaurosporine, UCN-01.
Investigational new drugs 1999;17(4):335-41.
1999: T Sunami; Kazuto Nishio; Fumihiko Kanzawa; Kazuya Fukuoka; S Kudoh; J Yoshikawa; Nagahiro Saijo
Combination effects of TAS-103, a novel dual topoisomerase I and II inhibitor, with other anticancer agents on human small cell lung cancer cells.
Cancer chemotherapy and pharmacology 1999;43(5):394-401.
1999: Fumihiko Kanzawa; Kazuto Nishio; Kazuya Fukuoka; T Sunami; Nagahiro Saijo
In vitro interactions of a new derivative of spicamycin, KRN5500, and other anticancer drugs using a three-dimensional model.
Cancer chemotherapy and pharmacology 1999;43(5):353-63.
1999: Hitoshi Arioka; Kazuto Nishio; Tomoyuki Ishida; Hisao Fukumoto; Kazuya Fukuoka; T Nomoto; Hirokazu Kurokawa; Hideyuki Yokote; S Abe; Nagahiro Saijo
Enhancement of cisplatin sensitivity in high mobility group 2 cDNA-transfected human lung cancer cells.
Japanese journal of cancer research : Gann 1999;90(1):108-15.
1999: H Kurokawa; K Nishio; H Fukumoto; A Tomonari; T Suzuki; Nagahiro Saijo
Alteration of caspase-3 (CPP32/Yama/apopain) in wild-type MCF-7, breast cancer cells.
Oncology reports 1999;6(1):33-7.
1998: Hideyuki Yokote; Kazuto Nishio; Hitoshi Arioka; Hirokazu Kurokawa; Kazuya Fukuoka; Hisao Fukumoto; Tomoyuki Ishida; T Terada; T Itakura; Nagahiro Saijo
The C-terminal domain of p53 catalyzes DNA-renaturation and strand exchange toward annealing between intact ssDNAs and toward eliminating damaged ssDNA from duplex formation through preferential recognition of damaged DNA by a duocarmycin.
Mutation research 1998;409(3):147-62.
1998: T Nomoto; Kazuto Nishio; Tomoyuki Ishida; M Mori; Nagahiro Saijo
Characterization of a human small-cell lung cancer cell line resistant to a new water-soluble camptothecin derivative, DX-8951f.
Japanese journal of cancer research : Gann 1998;89(11):1179-86.
1998: Ichiro Naruse; Yuji Heike; Seiji Hama; M Mori; Nagahiro Saijo
High concentrations of recombinant adenovirus expressing p16 gene induces apoptosis in lung cancer cell lines.
Anticancer research 1998;18(6A):4275-82.
1998: H Minami; Y Sasaki; Nagahiro Saijo; T Ohtsu; H Fujii; T Igarashi; K Itoh
Indirect-response model for the time course of leukopenia with anticancer drugs.
Clinical pharmacology and therapeutics 1998;64(5):511-21.
1998: I Sekine; Kaoru Kubota; Y Nishiwaki; Y Sasaki; T Tamura; Nagahiro Saijo
Response rate as an endpoint for evaluating new cytotoxic agents in phase II trials of non-small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9(10):1079-84.
1998: Y Iwamoto; Kazuto Nishio; Hisao Fukumoto; K Yoshimatsu; M Yamakido; Nagahiro Saijo
Preferential binding of E7010 to murine beta 3-tubulin and decreased beta 3-tubulin in E7010-resistant cell lines.
Japanese journal of cancer research : Gann 1998;89(9):954-62.
1998: I Sekine; H Fukuda; H Kunitoh; Nagahiro Saijo
Cancer chemotherapy in the elderly.
Japanese journal of clinical oncology 1998;28(8):463-73.
1998: Mitsuzi Yoshida; H Yokokura; H Hidaka; Tetsuro Ikekawa; Nagahiro Saijo
Mechanism of antitumor action of PKC activator, gnidimacrin.
International journal of cancer. Journal international du cancer 1998;77(2):243-50.
1998: Seiji Hama; Yuji Heike; Ichiro Naruse; M Takahashi; Hiroyuki Yoshioka; K Arita; Kaoru Kurisu; Corey K Goldman; D T Curiel; Nagahiro Saijo
Adenovirus-mediated p16 gene transfer prevents drug-induced cell death through G1 arrest in human glioma cells.
International journal of cancer. Journal international du cancer 1998;77(1):47-54.
1998: Kazuya Fukuoka; N Narita; Nagahiro Saijo
Increased expression of sialyl Lewis(x) antigen is associated with distant metastasis in lung cancer patients: immunohistochemical study on bronchofiberscopic biopsy specimens.
Lung cancer (Amsterdam, Netherlands) 1998;20(2):109-16.
1998: Hideo Kunitoh; Nagahiro Saijo; K Furuse; K Noda; M Ogawa
Neuromuscular toxicities of paclitaxel 210 mg m(-2) by 3-hour infusion.
British journal of cancer 1998;77(10):1686-8.
1998: T Kasai; Yuichiro Ohe; K Nishio; Hideo Kunitoh; Tomohide Tamura; Ikuo Sekine; K Kubota; Noboru Yamamoto; Y Nakamura; T Shinkai; Tetsuro Kodama; Nagahiro Saijo
Factors that influence the eligibility of cases for inclusion in clinical trials. The Lung Cancer Chemotherapy Study Group of the Japan Clinical Oncology Group.
Japanese journal of clinical oncology 1998;28(3):214-21.
1998: Nagahiro Saijo
[Academism and commercialism with development of new anticancer agents].
Gan to kagaku ryoho. Cancer & chemotherapy 1998;25(2):282-6.
1998: Nagahiro Saijo
New chemotherapeutic agents for the treatment of non-small cell lung cancer: the Japanese experience.
Chest 1998;113(1 Suppl):17S-23S.
1997: Yuji Heike; M Takahashi; T Ohira; Ichiro Naruse; Seiji Hama; Yuichiro Ohe; T Kasai; Hisao Fukumoto; K J Olsen; Eckhard R Podack; Nagahiro Saijo
Genetic immunotherapy by intrapleural, intraperitoneal and subcutaneous injection of IL-2 gene-modified Lewis lung carcinoma cells.
International journal of cancer. Journal international du cancer 1997;73(6):844-9.
1997: H Ogasawara; Kazuto Nishio; Tomoyuki Ishida; Hitoshi Arioka; Kazuya Fukuoka; Nagahiro Saijo
In vitro enhancement of antitumor activity of a water-soluble duocarmycin derivative, KW-2189, by caffeine-mediated DNA-repair inhibition in human lung cancer cells.
Japanese journal of cancer research : Gann 1997;88(11):1033-7.
1997: Kazuya Fukuoka; J Adachi; Kazuto Nishio; Hitoshi Arioka; Hirokazu Kurokawa; Hisao Fukumoto; Tomoyuki Ishida; T Nomoto; Hideyuki Yokote; Akira Tomonari; N Narita; J Yokota; Nagahiro Saijo
p16INK4 expression is associated with the increased sensitivity of human non-small cell lung cancer cells to DNA topoisomerase I inhibitors.
Japanese journal of cancer research : Gann 1997;88(10):1009-16.
1997: Ichiro Naruse; Nagahiro Saijo
[International consensus for lung cancer treatment].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24 Suppl 3():451-9.
1997: Toshihiro Suzuki; Kazuto Nishio; H Sasaki; Hirokazu Kurokawa; F Saito-Ohara; T Ikeuchi; S Tanabe; M Terada; Nagahiro Saijo
cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line.
Biochemical and biophysical research communications 1997;238(3):790-4.
1997: Tomoyuki Ishida; Kazuto Nishio; Hirokazu Kurokawa; Hitoshi Arioka; Hisao Fukumoto; Kazuya Fukuoka; T Nomoto; Hideyuki Yokote; S Hasegawa; Nagahiro Saijo
Circumvention of glutathione-mediated mitomycin C resistance by a novel mitomycin C analogue, KW-2149.
International journal of cancer. Journal international du cancer 1997;72(5):865-70.
1997: Kazuya Fukuoka; Nagahiro Saijo
[Antimitotic agents].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(11):1519-25.
1997: Akira Tomonari; Kazuto Nishio; Hirokazu Kurokawa; Hisao Fukumoto; Kazuya Fukuoka; Yasuo Iwamoto; Jitsuo Usuda; Toshihiro Suzuki; M Itakura; Nagahiro Saijo
Proximal 5'-flanking sequence of the human gamma-glutamylcysteine synthetase heavy subunit gene is involved in cisplatin-induced transcriptional up-regulation in a lung cancer cell line SBC-3.
Biochemical and biophysical research communications 1997;236(3):616-21.
1997: N Yamamoto; T Tamura; Yutaka Nishiwaki; Y Kurita; Y Kawakami; S Abe; T Nakabayashi; S Suzuki; T Matsuda; I Hayashi; T Takahashi; Nagahiro Saijo
Limited sampling model for the area under the concentration versus time curve of irinotecan and its application to a multicentric phase II trial.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(7):1087-92.
1997: Fumihiko Kanzawa; Kazuto Nishio; Kazuya Fukuoka; M Fukuda; T Kunimoto; Nagahiro Saijo
Evaluation of synergism by a novel three-dimensional model for the combined action of cisplatin and etoposide on the growth of a human small-cell lung-cancer cell line, SBC-3.
International journal of cancer. Journal international du cancer 1997;71(3):311-9.
1997: Hisao Fukumoto; M Nishio; Kazuto Nishio; Yuji Heike; Hitoshi Arioka; Hirokazu Kurokawa; Tomoyuki Ishida; Kazuya Fukuoka; T Nomoto; Yuichiro Ohe; Nagahiro Saijo
Interferon-gamma-inducing factor gene transfection into Lewis lung carcinoma cells reduces tumorigenicity in vivo.
Japanese journal of cancer research : Gann 1997;88(5):501-5.
1997: Seiji Hama; T Sadatomo; Hiroyuki Yoshioka; Kaoru Kurisu; Eiichi Tahara; Ichiro Naruse; Yuji Heike; Nagahiro Saijo
Transformation of human glioma cell lines with the p16 gene inhibits cell proliferation.
Anticancer research 1997;17(3C):1933-8.
1997: S Hama; Kaoru Kurisu; Nagahiro Saijo
[Cyclosporine as drug resistance modifiers; mechanism and clinical investigation].
Nihon rinsho. Japanese journal of clinical medicine 1997;55(5):1103-10.
1997: Fumihiko Kanzawa; Nagahiro Saijo
In vitro interaction between gemcitabine and other anticancer drugs using a novel three-dimensional model.
Seminars in oncology 1997;24(2 Suppl 7):S7-8-S7-16.
1997: Akira Tomonari; Kazuto Nishio; Hirokazu Kurokawa; Hitoshi Arioka; Tomoyuki Ishida; Hisao Fukumoto; Kazuya Fukuoka; T Nomoto; Yasuo Iwamoto; Yuji Heike; M Itakura; Nagahiro Saijo
Identification of cis-acting DNA elements of the human gamma-glutamylcysteine synthetase heavy subunit gene.
Biochemical and biophysical research communications 1997;232(2):522-7.
1997: Hirokazu Kurokawa; Kazuto Nishio; Tomoyuki Ishida; Hitoshi Arioka; Kazuya Fukuoka; T Nomoto; Hisao Fukumoto; Hideyuki Yokote; Nagahiro Saijo
Effect of glutathione depletion on cisplatin resistance in cancer cells transfected with the gamma-glutamylcysteine synthetase gene.
Japanese journal of cancer research : Gann 1997;88(2):108-10.
1997: Kazuto Nishio; Hirokazu Kurokawa; Tomoyuki Ishida; Kazuya Fukuoka; Nagahiro Saijo
[gamma-Glutamylcysteine synthetase and chemosensitivity].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(4):418-23.
1997: Takuji Okusaka; K Eguchi; T Kasai; T Kurata; N Yamamoto; Yuichiro Ohe; T Tamura; T Shinkai; Nagahiro Saijo
Serum levels of pro-gastrin-releasing peptide for follow-up of patients with small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(1):123-7.
1997: Fumihiko Kanzawa; Kazuto Nishio; Tomoyuki Ishida; M Fukuda; Hirokazu Kurokawa; Hisao Fukumoto; Y Nomoto; Kazuya Fukuoka; K Bojanowski; Nagahiro Saijo
Anti-tumour activities of a new benzo[c]phenanthridine agent, 2,3-(methylenedioxy)-5-methyl-7-hydroxy-8-methoxybenzo[c]phena nthridini um hydrogensulphate dihydrate (NK109), against several drug-resistant human tumour cell lines.
British journal of cancer 1997;76(5):571-81.
1997: Nagahiro Saijo
Chemotherapy: the more the better? Overview.
Cancer chemotherapy and pharmacology 1997;40 Suppl():S100-6.
1997: Hitoshi Arioka; Kazuto Nishio; Yuji Heike; S Abe; Nagahiro Saijo
In vitro and in vivo modulation by rhizoxin of non-P-glycoprotein-mediated vindesine resistance.
Journal of cancer research and clinical oncology 1997;123(4):195-200.
1997: N Yamamoto; T Tamura; Y Ohe; F Oshita; T Kasai; T Kurata; T Shinkai; K Eguchi; Nagahiro Saijo
Chronopharmacology of etoposide given by low dose prolonged infusion in lung cancer patients.
Anticancer research 1997;17(1B):669-72.
1997: Kazuto Nishio; Hitoshi Arioka; Nagahiro Saijo
[Apoptosis and chemosensitivity].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(2):216-21.
1997: F Oshita; K Noda; Yutaka Nishiwaki; A Fujita; Y Kurita; T Nakabayashi; K Tobise; S Abe; S Suzuki; I Hayashi; Y Kawakami; T Matsuda; S Tsuchiya; S Takahashi; T Tamura; Nagahiro Saijo
Phase II study of irinotecan and etoposide in patients with metastatic non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(1):304-9.
1996: Nagahiro Saijo
Clinical trials of irinotecan hydrochloride (CPT, campto injection, topotecin injection) in Japan.
Annals of the New York Academy of Sciences 1996;803():292-305.
1996: Kazuto Nishio; Tomoyuki Ishida; Hitoshi Arioka; Hirokazu Kurokawa; Kazuya Fukuoka; T Nomoto; Hisao Fukumoto; Hideyuki Yokote; Nagahiro Saijo
Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines.
Anticancer research 1996;16(6B):3387-95.
1996: M Fukuda; M Inomata; K Nishio; Kazuya Fukuoka; Fumihiko Kanzawa; Hitoshi Arioka; T Ishida; H Fukumoto; H Kurokawa; M Oka; Nagahiro Saijo
A topoisomerase II inhibitor, NK109, induces DNA single- and double-strand breaks and apoptosis.
Japanese journal of cancer research : Gann 1996;87(10):1086-91.
1996: T Ohira; Kazuto Nishio; Fumihiko Kanzawa; Tomoyuki Ishida; Yuichiro Ohe; Hitoshi Arioka; Y Funayama; H Ogasawara; H Kato; Nagahiro Saijo
Hypersensitivity of NIH3T3 cells transformed by H-ras gene to DNA-topoisomerase-I inhibitors.
International journal of cancer. Journal international du cancer 1996;67(5):702-8.
1996: Hisao Fukumoto; Kazuto Nishio; S Ohta; N Hanai; Nagahiro Saijo
Reversal of adriamycin resistance with chimeric anti-ganglioside GM2 antibody.
International journal of cancer. Journal international du cancer 1996;67(5):676-80.
1996: H Fukumoto; Nagahiro Saijo
[Selection of drugs for chemotherapy based on drug resistance marker].
Nihon rinsho. Japanese journal of clinical medicine 1996;54(6):1680-4.
1996: M Yoshida; W Feng; Nagahiro Saijo; Tetsuro Ikekawa
Antitumor activity of daphnane-type diterpene gnidimacrin isolated from Stellera chamaejasme L.
International journal of cancer. Journal international du cancer 1996;66(2):268-73.
1996: N Katsumata; K Eguchi; M Fukuda; N Yamamoto; Yuichiro Ohe; F Oshita; T Tamura; T Shinkai; Nagahiro Saijo
Serum levels of cytokines in patients with untreated primary lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(3):553-9.
1996: M Fukuda; Kazuto Nishio; Fumihiko Kanzawa; H Ogasawara; Tomoyuki Ishida; Hitoshi Arioka; K Bojanowski; M Oka; Nagahiro Saijo
Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38, in human small cell lung cancer cells.
Cancer research 1996;56(4):789-93.
1996: Y Funayama; Kazuto Nishio; K Wakabayashi; M Nagao; K Shimoi; T Ohira; S Hasegawa; Nagahiro Saijo
Effects of beta- and gamma-carboline derivatives of DNA topoisomerase activities.
Mutation research 1996;349(2):183-91.
1996: T Ohira; Kazuto Nishio; Yuichiro Ohe; Hitoshi Arioka; M Nishio; Y Funayama; H Ogasawara; M Fukuda; K Yazawa; H Kato; Nagahiro Saijo
Improvement by eicosanoids in cancer cachexia induced by LLC-IL6 transplantation.
Journal of cancer research and clinical oncology 1996;122(12):711-5.
1996: Nagahiro Saijo; Kazuto Nishio; S Ohta; Hitoshi Arioka; Y Funayama; Kazuya Fukuoka; H Kurokawa; T Nomoto; Tomoyuki Ishida; N Yamamoto; T Tamura; T Shinkai; K Eguchi; Yuichiro Ohe; H Kunito; T Ohtsu; Yasutsuna Sasaki
Progress in preclinical and clinical studies for the development of new anticancer drugs in Japan, with emphasis on taxanes.
Cancer chemotherapy and pharmacology 1996;38 Suppl():S11-5.
1995: Nagahiro Saijo; Kazuto Nishio; Y Takeda; Hitoshi Arioka; T Ishida; T Nomoto; Kazuya Fukuoka; H Kurokawa; H Fukumoto
Phorbol ester and okadaic acid-resistant cells: the crossroads of signal transduction and drug resistance.
The American journal of medicine 1995;99(6A):35S-39S.
1995: T Kasai; Nagahiro Saijo
[Can improvement in therapy decrease the rate of death due to lung cancer?].
Nihon Kyōbu Shikkan Gakkai zasshi 1995;33 Suppl():17-23.
1995: F Oshita; T Kurata; T Kasai; M Fakuda; N Yamamoto; Yuichiro Ohe; T Tamura; K Eguchi; T Shinkai; Nagahiro Saijo
Prospective evaluation of the feasibility of cisplatin-based chemotherapy for elderly lung cancer patients with normal organ functions.
Japanese journal of cancer research : Gann 1995;86(12):1198-202.
1995: Kazuto Nishio; Hitoshi Arioka; Tomoyuki Ishida; Hisao Fukumoto; Hirokazu Kurokawa; M Sata; M Ohata; Nagahiro Saijo
Enhanced interaction between tubulin and microtubule-associated protein 2 via inhibition of MAP kinase and CDC2 kinase by paclitaxel.
International journal of cancer. Journal international du cancer 1995;63(5):688-93.
1995: Hirokazu Kurokawa; Tomoyuki Ishida; Kazuto Nishio; Hitoshi Arioka; M Sata; Hisao Fukumoto; M Miura; Nagahiro Saijo
Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance.
Biochemical and biophysical research communications 1995;216(1):258-64.
1995: T Nomoto; Kazuto Nishio; Nagahiro Saijo
[Cell cycle regulation by anticancer agent].
Gan to kagaku ryoho. Cancer & chemotherapy 1995;22(12):1719-23.
1995: Fumihiko Kanzawa; Kazuto Nishio; N Kubota; Nagahiro Saijo
Antitumor activities of a new indolocarbazole substance, NB-506, and establishment of NB-506-resistant cell lines, SBC-3/NB.
Cancer research 1995;55(13):2806-13.
1995: F Oshita; N Yamamoto; M Fukuda; Yuichiro Ohe; T Tamura; K Eguchi; T Shinkai; Nagahiro Saijo
Correlation of therapeutic outcome in non-small cell lung cancer and DNA damage assayed by polymerase chain reaction in leukocytes damaged in vitro.
Cancer research 1995;55(11):2334-7.
1995: M Fukuda; Yuichiro Ohe; F Kanzawa; M Oka; K Hara; Nagahiro Saijo
Evaluation of novel platinum complexes, inhibitors of topoisomerase I and II in non-small cell lung cancer (NSCLC) sublines resistant to cisplatin.
Anticancer research 1995;15(2):393-8.
1995: Nagahiro Saijo
[Strategies for the overcoming of drug resistance].
Gan to kagaku ryoho. Cancer & chemotherapy 1995;22(3):371-81.
1995: Yuji Heike; M Takahashi; T Ohira; Hitoshi Arioka; Y Funayama; Kazuto Nishio; H Ogasawara; Nagahiro Saijo
In vivo screening models of cisplatin-resistant human lung cancer cell lines using SCID mice.
Cancer chemotherapy and pharmacology 1995;35(3):200-4.
1995: H Ogasawara; Kazuto Nishio; Fumihiko Kanzawa; Y S Lee; Y Funayama; T Ohira; Y Kuraishi; Y Isogai; Nagahiro Saijo
Intracellular carboxyl esterase activity is a determinant of cellular sensitivity to the antineoplastic agent KW-2189 in cell lines resistant to cisplatin and CPT-11.
Japanese journal of cancer research : Gann 1995;86(1):124-9.
1995: M Inomata; Nagahiro Saijo; K Kawashima; A Kaneko; Y Fujiwara; H Kunikane; Y Tanaka
Induction of apoptosis in cultured retinoblastoma cells by the protein phosphatase inhibitor, okadaic acid.
Journal of cancer research and clinical oncology 1995;121(12):729-38.
1994: Kazuto Nishio; K Miura; T Ohira; Yuji Heike; Nagahiro Saijo
Genistein, a tyrosine kinase inhibitor, decreased the affinity of p56lck to beta-chain of interleukin-2 receptor in human natural killer (NK)-rich cells and decreased NK-mediated cytotoxicity.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;207(2):227-33.
1994: H Kondo; Fumihiko Kanzawa; Kazuto Nishio; S Saito; Nagahiro Saijo
In vitro and in vivo effects of cisplatin and etoposide in combination on small cell lung cancer cell lines.
Japanese journal of cancer research : Gann 1994;85(10):1050-6.
1994: H Koga; K Eguchi; T Shinkai; T Tamura; Yuichiro Ohe; F Oshita; Nagahiro Saijo; H Kondo; K Oki; H Okura
Preliminary evaluation of the new tumor marker, CYFRA 21-1, in lung cancer patients.
Japanese journal of clinical oncology 1994;24(5):263-8.
1994: K Bojanowski; Kazuto Nishio; M Fukuda; Annette K Larsen; Nagahiro Saijo
Effect of suramin on p34cdc2 kinase in vitro and in extracts from human H69 cells: evidence for a double mechanism of action.
Biochemical and biophysical research communications 1994;203(3):1574-80.
1994: Y Takeda; Kazuto Nishio; N Kubota; K Miura; T Morikage; T Ohmori; S Kudoh; H Niitani; Nagahiro Saijo
Establishment of a human small-cell lung-cancer subline resistant to okadaic acid.
International journal of cancer. Journal international du cancer 1994;58(6):882-90.
1994: Y Takeda; Kazuto Nishio; H Niitani; Nagahiro Saijo
Reversal of multidrug resistance by tyrosine-kinase inhibitors in a non-P-glycoprotein-mediated multidrug-resistant cell line.
International journal of cancer. Journal international du cancer 1994;57(2):229-39.
1994: H Ogasawara; Kazuto Nishio; Y Takeda; T Ohmori; N Kubota; Y Funayama; T Ohira; Y Kuraishi; Y Isogai; Nagahiro Saijo
A novel antitumor antibiotic, KW-2189 is activated by carboxyl esterase and induces DNA strand breaks in human small cell lung cancer cells.
Japanese journal of cancer research : Gann 1994;85(4):418-25.
1994: S Ohta; Kazuto Nishio; N Kubota; T Ohmori; Y Funayama; T Ohira; H Nakajima; M Adachi; Nagahiro Saijo
Characterization of a taxol-resistant human small-cell lung cancer cell line.
Japanese journal of cancer research : Gann 1994;85(3):290-7.
1994: S Okamoto-Kubo; Kazuto Nishio; Yuji Heike; M Yoshida; T Ohmori; Nagahiro Saijo
Apoptosis induced by etoposide in small-cell lung cancer cell lines.
Cancer chemotherapy and pharmacology 1994;33(5):385-90.
1994: M Inomata; A Kaneko; Nagahiro Saijo; S Tokura
Culture of retinoblastoma cells from clinical specimens: growth-promoting effect of 2-mercaptoethanol.
Journal of cancer research and clinical oncology 1994;120(3):149-55.
1994: Nagahiro Saijo; Kazuto Nishio; N Kubota; Fumihiko Kanzawa; T Shinkai; A Karato; Yasutsuna Sasaki; K Eguchi; T Tamura; Yuichiro Ohe
7-Ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy camptothecin: mechanism of resistance and clinical trials.
Cancer chemotherapy and pharmacology 1994;34 Suppl():S112-7.
1994: N Kubota; Kazuto Nishio; Y Takeda; T Ohmori; Y Funayama; H Ogasawara; T Ohira; H Kunikane; Y Terashima; Nagahiro Saijo
Characterization of an etoposide-resistant human ovarian cancer cell line.
Cancer chemotherapy and pharmacology 1994;34(3):183-90.
1993: T Shinkai; Nagahiro Saijo
[Phase II clinical trials in patients with lung cancer].
Nihon Kyōbu Shikkan Gakkai zasshi 1993;31 Suppl():232-44.
1993: Y Funayama; Kazuto Nishio; Y Takeda; N Kubota; T Ohira; T Ohmori; S Ohta; H Ogasawara; S Hasegawa; Nagahiro Saijo
Suramin inhibits the phosphorylation and catalytic activity of DNA topoisomerase II in human lung cancer cells.
Anticancer research 1993;13(6A):1981-8.
1993: T Morikage; T Ohmori; Kazuto Nishio; Y Fujiwara; Y Takeda; Nagahiro Saijo
Modulation of cisplatin sensitivity and accumulation by amphotericin B in cisplatin-resistant human lung cancer cell lines.
Cancer research 1993;53(14):3302-7.
1993: S Ohta; AWTAR KRISHAN; Kazuto Nishio; T Ohmori; H Kunikane; M Inomata; T Takahashi; Nagahiro Saijo
Effect of taxol on vinblastine sulfate-induced crystallization of tubulin.
Anticancer research 1993;13(4):873-7.
1993: Kazuto Nishio; T Morikage; T Ohmori; N Kubota; Y Takeda; S Ohta; K Yazawa; Nagahiro Saijo
Novel water-soluble derivatives of docosahexaenoic acid increase diacylglycerol production mediated by phosphatidylcholine-specific phospholipase C.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1993;203(2):200-8.
1993: A Kojima; T Shinkai; Nagahiro Saijo
Cytogenetic effects of CPT-11 and its active metabolite, SN-38 on human lymphocytes.
Japanese journal of clinical oncology 1993;23(2):116-22.
1993: Yuichiro Ohe; Eckhard R Podack; K J Olsen; Y Miyahara; T Ohira; K Miura; Kazuto Nishio; Nagahiro Saijo
Combination effect of vaccination with IL2 and IL4 cDNA transfected cells on the induction of a therapeutic immune response against Lewis lung carcinoma cells.
International journal of cancer. Journal international du cancer 1993;53(3):432-7.
1993: T Ohmori; T Morikage; Y Sugimoto; Y Fujiwara; K Kasahara; Kazuto Nishio; S Ohta; Yasutsuna Sasaki; T Takahashi; Nagahiro Saijo
The mechanism of the difference in cellular uptake of platinum derivatives in non-small cell lung cancer cell line (PC-14) and its cisplatin-resistant subline (PC-14/CDDP).
Japanese journal of cancer research : Gann 1993;84(1):83-92.
1992: T Miya; Yasutsuna Sasaki; A Karato; Nagahiro Saijo
Pharmacokinetic study of mitomycin C with emphasis on the influence of aging.
Japanese journal of cancer research : Gann 1992;83(12):1382-5.
1992: T Ohira; Yuichiro Ohe; Nagahiro Saijo
[Induction of tumor immunity by cytokine cDNA transfected Lewis lung carcinoma].
Nihon Kyōbu Shikkan Gakkai zasshi 1992;30 Suppl():48-51.
1992: H Okamoto; Nagahiro Saijo; T Shinkai; K Eguchi; Yasutsuna Sasaki; T Tamura; Yuichiro Ohe; A Kojima; H Kunikane; A Karato
Chemotherapy-induced anemia in patients with primary lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1992;3(10):819-24.
1992: M Yoshida; Y Tanaka; T Eguchi; N Ikekawa; Nagahiro Saijo
Effect of hexafluoro-1,25-dihydroxyvitamin D3 and sodium butyrate combination on differentiation and proliferation of HL-60 leukemia cells.
Anticancer research 1992;12(6B):1947-52.
1992: N Kubota; Fumihiko Kanzawa; Kazuto Nishio; Y Takeda; T Ohmori; Y Fujiwara; Y Terashima; Nagahiro Saijo
Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line.
Biochemical and biophysical research communications 1992;188(2):571-7.
1992: Kazuto Nishio; T Morikage; N Kubota; T Ohmori; Y Takeda; Y Fujiwara; K Miki; K Abe; Nagahiro Saijo
Alteration of type II regulatory subunit of cAMP-dependent protein kinase in human cisplatin-resistant cells as a basis of collateral sensitivity to 8-chloro-cAMP.
Japanese journal of cancer research : Gann 1992;83(7):754-60.
1992: Y Sugimoto; Yuichiro Ohe; Kazuto Nishio; T Ohmori; T Morikage; Y Fujiwara; Nagahiro Saijo
Mechanisms of collateral sensitivity to fluorouracil of a cis-diamminedichloroplatinum(II)-resistant human non-small lung cancer cell line.
British journal of cancer 1992;65(6):857-64.
1992: Kazuto Nishio; Y Sugimoto; Y Fujiwara; T Ohmori; T Morikage; Y Takeda; M Ohata; Nagahiro Saijo
Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by cis-diamminedichloroplatinum(II).
The Journal of clinical investigation 1992;89(5):1622-8.
1992: H Kondo; T Shigekiyo; A Kojima; S Saito; Nagahiro Saijo
Acquired factor VIII inhibitor in a patient with adenocarcinoma of the lung.
Japanese journal of clinical oncology 1992;22(1):49-53.
1992: Kazuto Nishio; Y Sugimoto; K Kasahara; Y Fujiwara; S Nishiwaki; H Fujiki; M Ohata; Nagahiro Saijo
Increased phosphorylation of nuclear phosphoproteins in human lung-cancer cells resistant to cis-diamminedichloroplatinum (II).
International journal of cancer. Journal international du cancer 1992;50(3):438-42.
1992: K Kasahara; Y Fujiwara; Y Sugimoto; Kazuto Nishio; T Tamura; T Matsuda; Nagahiro Saijo
Determinants of response to the DNA topoisomerase II inhibitors doxorubicin and etoposide in human lung cancer cell lines.
Journal of the National Cancer Institute 1992;84(2):113-8.
1992: K Minato; T Manabe; N Okuyama; Yasutsuna Sasaki; K Nakagawa; Nagahiro Saijo
Differences in cellular proteins between high and low metastatic potential sublines from the methylcholanthrene-induced rat fibrosarcoma cell line.
Oncology 1992;49(2):143-6.
1992: F Oshita; Y Fujiwara; Nagahiro Saijo
Radiation sensitivities in various anticancer-drug-resistant human lung cancer cell lines and mechanism of radiation cross-resistance in a cisplatin-resistant cell line.
Journal of cancer research and clinical oncology 1992;119(1):28-34.
1992: Y Sugimoto; Yuichiro Ohe; Kazuto Nishio; T Ohmori; Y Fujiwara; Nagahiro Saijo
In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines.
Cancer chemotherapy and pharmacology 1992;30(6):417-22.
1992: Nagahiro Saijo
Combined modality therapy for small cell lung cancer.
Oncology 1992;49 Suppl 1():2-9; discussion 10.
1992: S Kubo; M Matsutani; K Nakagawa; T Ogura; H Esumi; Nagahiro Saijo
Participation of poly(ADP-ribose) polymerase in the drug sensitivity in human lung cancer cell lines.
Journal of cancer research and clinical oncology 1992;118(4):244-8.
1991: F Oshita; T Tamura; H Okamoto; T Miya; A Kojima; Yuichiro Ohe; Yasutsuna Sasaki; K Eguchi; T Shinkai; Nagahiro Saijo
The frequency and management of infectious episodes and sepsis in small cell lung cancer patients receiving intensive chemotherapy with granulocyte-colony stimulating factor.
Japanese journal of clinical oncology 1991;21(5):353-9.
1991: K Kasahara; Y Fujiwara; Kazuto Nishio; T Ohmori; Y Sugimoto; K Komiya; T Matsuda; Nagahiro Saijo
Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin.
Cancer research 1991;51(12):3237-42.
1991: T Morikage; M Bungo; M Inomata; M Yoshida; T Ohmori; Y Fujiwara; Kazuto Nishio; Nagahiro Saijo
Reversal of cisplatin resistance with amphotericin B in a non-small cell lung cancer cell line.
Japanese journal of cancer research : Gann 1991;82(6):747-51.
1991: Yasutsuna Sasaki; T Amano; M Morita; T Shinkai; K Eguchi; T Tamura; Yuichiro Ohe; A Kojima; Nagahiro Saijo
Phase I study and pharmacological analysis of cis-diammine(glycolato)platinum (254-S; NSC 375101D) administered by 5-day continuous intravenous infusion.
Cancer research 1991;51(5):1472-7.
1991: S Niimi; K Nakagawa; J Yokota; Y Tsunokawa; Kazuto Nishio; Y Terashima; M Shibuya; M Terada; Nagahiro Saijo
Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and/or c-H-ras genes.
British journal of cancer 1991;63(2):237-41.
1991: F Oshita; T Shinkai; T Miya; A Kojima; Yuichiro Ohe; T Tamura; Yasutsuna Sasaki; K Eguchi; Nagahiro Saijo
[The relation between myelotoxicity and performance status or aging in chemotherapy of non-small cell lung cancer].
Nihon Kyōbu Shikkan Gakkai zasshi 1991;29(2):231-8.
1991: K Yamada; Nagahiro Saijo; A Kojima; Yuichiro Ohe; T Tamura; Yasutsuna Sasaki; K Eguchi; T Shinkai; T Goya; H Kondou
A retrospective analysis of patients receiving surgery after chemotherapy for small cell lung cancer.
Japanese journal of clinical oncology 1991;21(1):39-45.
1991: Y Soejima; W M Shen; K Minato; K Nishio; Y Sugimoto; Y Fujiwara; T Tamura; K Hara; Nagahiro Saijo
The development of a treatment model for lymph node metastasis in nude mice transplanted with rat fibrosarcoma clone A.
Invasion & metastasis 1991;11(3):174-80.
1991: A Kojima; T Ikeuchi; M Inomata; T Shinkai; K Ishihara; M Noguchi; Nagahiro Saijo
Y/6 chromosome translocation in a male with triple primary cancers involving the breast.
Journal of cancer research and clinical oncology 1991;117(5):479-83.
1991: Yasutsuna Sasaki; T Shinkai; K Eguchi; T Tamura; Yuichiro Ohe; T Ohmori; Nagahiro Saijo
Prediction of the antitumor activity of new platinum analogs based on their ex vivo pharmacodynamics as determined by bioassay.
Cancer chemotherapy and pharmacology 1991;27(4):263-70.
1991: T Shinkai; K Eguchi; Yasutsuna Sasaki; T Tamura; Yuichiro Ohe; A Kojima; F Oshita; Nagahiro Saijo
A randomised clinical trial of vindesine plus cisplatin versus mitomycin plus vindesine and cisplatin in advanced non-small cell lung cancer.
European journal of cancer (Oxford, England : 1990) 1991;27(5):571-5.
1990: Y Fujiwara; K Kasahara; Y Sugimoto; Kazuto Nishio; T Ohmori; Nagahiro Saijo
Detection of proteins that recognize platinum-modified DNA using gel mobility shift assay.
Japanese journal of cancer research : Gann 1990;81(12):1210-3.
1990: Fumihiko Kanzawa; Y Sugimoto; K Minato; K Kasahara; M Bungo; K Nakagawa; Y Fujiwara; L F Liu; Nagahiro Saijo
Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: characterization and mechanism of resistance.
Cancer research 1990;50(18):5919-24.
1990: K Nishio; Y Sugimoto; K Nakagawa; S Niimi; Y Fujiwara; M Bungo; K Kasahara; H Fujiki; Nagahiro Saijo
Cross-resistance to tumour promoters in human cancer cell lines resistant to adriamycin or cisplatin.
British journal of cancer 1990;62(3):415-9.
1990: M Fukuda; Yasutsuna Sasaki; M Morita; R Tsuchiya; Y Matsuno; M Noguchi; Nagahiro Saijo
Large cell carcinoma of the lung secreting human chorionic gonadotropin which responded to combination chemotherapy: case report.
Japanese journal of clinical oncology 1990;20(3):299-305.
1990: M Fukuda; Yasutsuna Sasaki; M Sakamoto; M Noguchi; Nagahiro Saijo
Primary lung cancer in an 18-year-old boy: case report.
Japanese journal of clinical oncology 1990;20(2):177-81.
1990: M Bungo; Y Fujiwara; K Kasahara; K Nakagawa; Yuichiro Ohe; Yasutsuna Sasaki; S Irino; Nagahiro Saijo
Decreased accumulation as a mechanism of resistance to cis-diamminedichloroplatinum(II) in human non-small cell lung cancer cell lines: relation to DNA damage and repair.
Cancer research 1990;50(9):2549-53.
1990: Y Fujiwara; Y Sugimoto; K Kasahara; M Bungo; M Yamakido; Kenneth D Tew; Nagahiro Saijo
Determinants of drug response in a cisplatin-resistant human lung cancer cell line.
Japanese journal of cancer research : Gann 1990;81(5):527-35.
1990: K Nakagawa; Nagahiro Saijo; S Tsuchida; M Sakai; Y Tsunokawa; J Yokota; M Muramatsu; K Sato; M Terada; Kenneth D Tew
Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.
The Journal of biological chemistry 1990;265(8):4296-301.
1990: M Bungo; K Nakagawa; Nagahiro Saijo
[A mechanism of cisplatin resistance in a cisplatin resistant lung cancer cell line].
Gan to kagaku ryoho. Cancer & chemotherapy 1990;17(3 Pt 2):515-6.
1990: M Fukuda; T Shinkai; K Eguchi; Yasutsuna Sasaki; T Tamura; Yuichiro Ohe; A Kojima; F Oshita; K Hara; Nagahiro Saijo
Phase II study of (glycolate-O,O') diammineplatinum(II), a novel platinum complex, in the treatment of non-small-cell lung cancer.
Cancer chemotherapy and pharmacology 1990;26(6):393-6.
1990: K Minato; Fumihiko Kanzawa; Kazuto Nishio; K Nakagawa; Y Fujiwara; Nagahiro Saijo
Characterization of an etoposide-resistant human small-cell lung cancer cell line.
Cancer chemotherapy and pharmacology 1990;26(5):313-7.
1990: M Sakurai; M Iigo; Yasutsuna Sasaki; K Nakagawa; Y Fujiwara; T Tamura; Yuichiro Ohe; M Bungo; Nagahiro Saijo
Lack of correlation between interferon levels induced by polyribonucleotides and their antimetastatic effect.
Oncology 1990;47(3):251-6.
1989: T Shinkai; Nagahiro Saijo; K Eguchi; Yasutsuna Sasaki; T Tamura; Y Fujiwara; A Kojima; K Nakagawa; K Minato; T Nakajima
Serial measurement of sister chromatid exchanges in the peripheral lymphocytes of patients with lung cancer receiving chemotherapy in relation to bone marrow toxicity.
Japanese journal of cancer research : Gann 1989;80(8):783-6.
1989: Yuichiro Ohe; K Nakagawa; Y Fujiwara; Yasutsuna Sasaki; K Minato; M Bungo; S Niimi; N Horichi; M Fukuda; Nagahiro Saijo
In vitro evaluation of the new anticancer agents KT6149, MX-2, SM5887, menogaril, and liblomycin using cisplatin- or adriamycin-resistant human cancer cell lines.
Cancer research 1989;49(15):4098-102.
1989: T Shinkai; Nagahiro Saijo; K Eguchi; Yasutsuna Sasaki; T Tamura; Y Fujiwara; M Mae; M Fukuda; Yuichiro Ohe; S Sasaki
Control of cisplatin-induced delayed emesis with metoclopramide and dexamethasone: a randomized controlled trial.
Japanese journal of clinical oncology 1989;19(1):40-4.
1989: Y Ohsaki; Yuichiro Ohe; S Niimi; K Nakagawa; K Minato; M Bungo; Yasutsuna Sasaki; N Horichi; K Eguchi; Nagahiro Saijo
[Effects of recombinant human colony stimulating factor (rh-CSFs) on colony formation of lung cancer cell lines].
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(3 Pt 1):431-3.
1989: T Tamura; T Shinkai; K Eguchi; Yasutsuna Sasaki; Y Fujiwara; M Fukuda; Yuichiro Ohe; K Nakagawa; K Minato; Nagahiro Saijo
Phase II study of carboplatin in non-small cell lung cancer.
Japanese journal of clinical oncology 1989;19(1):51-5.
1989: Atsushi Ohtsu; Yasutsuna Sasaki; T Tamura; Y Fujiwara; Yuichiro Ohe; K Minato; K Nakagawa; M Bungo; Nagahiro Saijo
Inhibition of colony formation of drug-resistant human tumor cell lines by combinations of interleukin-2-activated killer cells and antitumor drugs.
Japanese journal of cancer research : Gann 1989;80(3):265-70.
1989: T Tamura; Yasutsuna Sasaki; T Shinkai; K Eguchi; M Sakurai; Y Fujiwara; K Nakagawa; K Minato; M Bungo; Nagahiro Saijo
Phase I study of combination therapy with interleukin 2 and beta-interferon in patients with advanced malignancy.
Cancer research 1989;49(3):730-5.
1988: A Ozaki; H Nakano; K Minato; K Nakagawa; Yasutsuna Sasaki; Nagahiro Saijo
The difference in surface phenotypes between cytotoxic lymphocytes induced in vivo by systemic administration of human recombinant interleukin-2 and lymphokine activated killer cells induced in vitro.
European journal of cancer & clinical oncology 1988;24(6):1055-60.
1988: Fumihiko Kanzawa; Y Matsushima; H Nakano; K Nakagawa; H Takahashi; Yasutsuna Sasaki; Nagahiro Saijo
Antitumor activity of a new platinum compound (glycolate-o,o') diammineplatinum (II) (254-S), against non-small cell lung carcinoma grown in a human tumor clonogenic assay system.
Anticancer research 1988;8(3):323-7.
1988: W S Hong; Nagahiro Saijo; Yasutsuna Sasaki; K Minato; H Nakano; K Nakagawa; Y Fujiwara; K Nomura; P R Twentyman
Establishment and characterization of cisplatin-resistant sublines of human lung cancer cell lines.
International journal of cancer. Journal international du cancer 1988;41(3):462-7.
1988: J Ishihara; Nagahiro Saijo; F Kanzawa; Y Matsushima; Yasutsuna Sasaki; H Takahashi; H Nakano; K Nakagawa; Waun Ki Hong; A Hoshi
Augmentation of colony formation of cultured cell lines by pleural effusion from patients with lung cancer.
European journal of cancer & clinical oncology 1988;24(3):497-8.
1988: T Tamura; Nagahiro Saijo; T Shinkai; K Eguchi; Yasutsuna Sasaki; M Sakurai; Y Fujiwara; H Nakano; K Nakagawa; K Minato
Phase II study of carboplatin in small cell lung cancer.
Japanese journal of clinical oncology 1988;18(1):27-32.
1988: T Shinkai; Nagahiro Saijo; K Eguchi; Yasutsuna Sasaki; T Tamura; M Sakurai; J Suga; H Nakano; K Nakagawa; Waun Ki Hong
Cytogenetic effect of carboplatin on human lymphocytes.
Cancer chemotherapy and pharmacology 1988;21(3):203-7.
1988: M Sakurai; M Iigo; T Tamura; A Otsu; Yasutsuna Sasaki; H Nakano; K Nakagawa; K Minato; Yuichiro Ohe; Nagahiro Saijo
Comparative study of the antitumor effect of two types of murine recombinant interferons, (beta) and (gamma), against B16-F10 melanoma.
Cancer immunology, immunotherapy : CII 1988;26(2):109-13.
1988: T Sano; Nagahiro Saijo; Yasutsuna Sasaki; T Shinkai; K Eguchi; T Tamura; M Sakurai; H Takahashi; H Nakano; K Nakagawa
Three schedules of recombinant human interleukin-2 in the treatment of malignancy: side effects and immunologic effects in relation to serum level.
Japanese journal of cancer research : Gann 1988;79(1):131-43.
1988: N Horiuchi; K Nakagawa; Yasutsuna Sasaki; K Minato; Y Fujiwara; K Nezu; Yuichiro Ohe; Nagahiro Saijo
In vitro antitumor activity of mitomycin C derivative (RM-49) and new anticancer antibiotics (FK973) against lung cancer cell lines determined by tetrazolium dye (MTT) assay.
Cancer chemotherapy and pharmacology 1988;22(3):246-50.
1987: Yasutsuna Sasaki; F Kanzawa; H Takahashi; Y Matsushima; H Nakano; K Nakagawa; W S Hong; K Minato; Y Fujiwara; Nagahiro Saijo
In vitro antitumor effect of recombinant human tumor necrotizing factor on cultured human cancer cell lines and freshly isolated lung cancer cells by the human tumor clonogenic assay.
Investigational new drugs 1987;5(4):353-9.
1987: H Taitou; M Sakurai; T Tamura; Yasutsuna Sasaki; K Eguchi; T Shinkai; H Ookura; Nagahiro Saijo
[The changes in serum neuron-specific enolase in patients with small cell lung cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 1987;14(11):3046-9.
1987: S Nino; H Umehara; I Inoue; T Tamura; Yasutsuna Sasaki; M Sakurai; T Shinkai; K Eguchi; Nagahiro Saijo; K Suemasu
[A randomized controlled trial of acute and delayed cisplatin-induced emesis with metoclopramide, dexamethasone and prochlorperazine].
Gan to kagaku ryoho. Cancer & chemotherapy 1987;14(10):2881-4.
1987: Fumihiko Kanzawa; Y Matsushima; C D Chiang; H Nakano; K Nakagawa; H Takahashi; Yasutsuna Sasaki; Nagahiro Saijo
Comparative studies of pulse and continuous exposure in human tumor clonogenic assay.
Journal of pharmacobio-dynamics 1987;10(9):449-51.
1987: Yasutsuna Sasaki; T Ohta; T Tamura; K Eguchi; T Shinkai; M Noguchi; Nagahiro Saijo
A case report of pulmonary adenocarcinoma responding to (glycolato-0,0') diammineplatinum (II), a new platinum complex.
Japanese journal of clinical oncology 1987;17(3):285-90.
1987: J Taguchi; Nagahiro Saijo; K Miura; T Shinkai; K Eguchi; Yasutsuna Sasaki; T Tamura; M Sakurai; K Minato; Y Fujiwara
Prediction of hematologic toxicity of carboplatin by creatinine clearance rate.
Japanese journal of cancer research : Gann 1987;78(9):977-82.
1987: H Nakano; Nagahiro Saijo; Yasutsuna Sasaki; H Takahashi; K Nakagwa; W S Hong; F Kanzawa; Y Matsushima; H Morikawa; M Sakurai
[In vitro drug sensitivity test].
Gan to kagaku ryoho. Cancer & chemotherapy 1987;14(5 Pt 2):1620-8.
1987: F Kanzawa; Y Matsushima; Anne W Hamburger; J Ishihara; Yasutsuna Sasaki; E Shimizu; K Eguchi; T Shinkai; Nagahiro Saijo; N Miyazawa
Human tumor clonogenic assay for carcinoma of the lung. II. Factors that influence colony formation in soft agar.
Oncology 1987;44(3):150-5.
1987: J Ishihara; Nagahiro Saijo; Yasutsuna Sasaki; H Nakano; A Ozaki; H Takahashi; M Sakurai; K Nakagawa; M Iigo; F Kanzawa
The different effects of recombinant human tumor necrosis factor on rat fibrosarcoma sublines.
Cancer immunology, immunotherapy : CII 1987;24(3):185-9.
1986: F Kanzawa; Y Matsushima; J Ishihara; E Shimizu; Yasutsuna Sasaki; K Eguchi; T Shinkai; Nagahiro Saijo; N Miyazawa; Anne W Hamburger
In vitro chemosensitivity patterns of carcinoma of the lung in human tumor clonogenic assay.
Journal of pharmacobio-dynamics 1986;9(9):715-21.
1986: Yasutsuna Sasaki; Nagahiro Saijo; Y C Lee; H Takahashi; J Ishihara; M Sakurai; T Sano; H Nakano; F Kanzawa; A Hoshi
A bioassay of cisplatin by human tumor clonogenic assay.
Japanese journal of cancer research : Gann 1986;77(5):494-501.
1986: Nagahiro Saijo; A Ozaki; M Sakurai; J Ishihara; H Takahashi; Yasutsuna Sasaki; A Hoshi; Anne W Hamburger
Reduction of pulmonary metastases of B16 melanoma by human recombinant interleukin 2 and lymphokine-activated killer cells in immunosuppressed C57BL/6 mice receiving anticancer agent.
Japanese journal of cancer research : Gann 1986;77(5):487-93.
1986: H Futami; Nagahiro Saijo; Yasutsuna Sasaki; M Sakurai; H Nomori; H Takahashi; J Ishihara; A Hoshi; K Koyama; Anne W Hamburger
Differences of host immune response and of sensitivity to chemotherapeutic agents between two clones of rat fibrosarcoma with different metastatic potential.
Japanese journal of cancer research : Gann 1986;77(5):480-6.
1986: J Fujita; Nagahiro Saijo; Yasutsuna Sasaki; H Futami; J Ishihara; H Takahashi; A Hoshi; Anne W Hamburger
Detection of cytotoxicity of freshly obtained lymphocytes and of lymphocytes activated with recombinant interleukin II (rIL-2) against lung cancer cell lines by human tumor clonogenic assay (HTCA).
European journal of cancer & clinical oncology 1986;22(4):445-50.
1986: Nagahiro Saijo; A Ozaki; J Ishihara; M Sakurai; Yasutsuna Sasaki; H Takahashi; T Sano; A Hoshi
[Strategy of cancer treatment using human recombinant interleukin 2 and lymphokine activated killer cells].
Gan to kagaku ryoho. Cancer & chemotherapy 1986;13(4 Pt 2):1290-7.
1986: Y C Lee; Nagahiro Saijo; Yasutsuna Sasaki; H Takahashi; M Sakurai; J Ishihara; T Sano; A Hoshi; K M Chen; Anne W Hamburger
Antitumor effect of two-drug simultaneous or sequential use of cisplatin, vindesine or etoposide on human pulmonary adenocarcinoma cell lines in tumor clonogenic assay.
Japanese journal of cancer research : Gann 1986;77(3):312-8.
1985: Y C Lee; Nagahiro Saijo; Yasutsuna Sasaki; H Takahashi; M Sakurai; J Ishihara; A Hoshi; K M Chen; Anne W Hamburger
Clonogenic patterns of human pulmonary adenocarcinoma cell lines (PC-9, PC-13 and PC-14) and how they influence the results of test for chemosensitivity to cisplatin in the human tumor clonogenic assay.
Japanese journal of clinical oncology 1985;15(4):637-44.
1985: F Kanzawa; Y Matsushima; J Ishihara; E Shimizu; Yasutsuna Sasaki; Nagahiro Saijo; N Miyazawa
The use of human tumor clonogenic assay in predicting combination effect of cisplatin plus vindesine in carcinoma of the lung.
Journal of pharmacobio-dynamics 1985;8(10):885-8.
1985: J Fujita; Nagahiro Saijo; K Eguchi; T Shinkai; K Tominaga; Yasutsuna Sasaki; H Futami; M Sakurai; J Ishihara; H Takahashi
Phase II study of vindesine in patients with non-small cell lung cancer.
Japanese journal of cancer research : Gann 1985;76(9):902-5.
1985: J Fujita; Nagahiro Saijo; K Eguchi; T Shinkai; K Tominaga; Yasutsuna Sasaki; M Sakurai; H Futami; J Ishihara; H Takahashi
Preliminary phase II study of adriamycin (ADM) in patients with non-small cell lung cancer (NSCLC).
Japanese journal of clinical oncology 1985;15(2):365-8.