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Nagahiro Saijo

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Yamamoto Noboru; Tamura Tomohide; Kurata Takayasu; Yamamoto Nobuyuki; Sekine Ikuo; Kunitoh Hideo; Ohe Yuichiro; Saijo Nagahiro
A dose-finding and pharmacokinetic study of nedaplatin in elderly patients with advanced non-small cell lung cancer.
Wakelee Heather; Loo Bill W; Kernstine Kemp H; Putnam Joe Bill; Edelman Martin J; Vokes Everett E; Schiller Joan H; Baas Paul; Saijo Nagahiro; Adjei Alex; Goss Glenwood; Choy Hak; Gandara David R
Cooperative group research efforts in thoracic malignancies 2009: a review from the 10th Annual International Lung Cancer Congress.
Sangha Randeep; Lara Primo N; Adjei Alex A; Baas Paul; Choy Hak; Gaspar Laurie E; Goss Glenwood; Saijo Nagahiro; Schiller Joan H; Vokes Everett E; Gandara David R
Cooperative group research endeavors in small-cell lung cancer: current and future directions.

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All Publications

2009: Yamamoto Noboru; Tamura Tomohide; Kurata Takayasu; Yamamoto Nobuyuki; Sekine Ikuo; Kunitoh Hideo; Ohe Yuichiro; Saijo Nagahiro
A dose-finding and pharmacokinetic study of nedaplatin in elderly patients with advanced non-small cell lung cancer.
Cancer chemotherapy and pharmacology 2009;65(1):79-88.
2009: Wakelee Heather; Loo Bill W; Kernstine Kemp H; Putnam Joe Bill; Edelman Martin J; Vokes Everett E; Schiller Joan H; Baas Paul; Saijo Nagahiro; Adjei Alex; Goss Glenwood; Choy Hak; Gandara David R
Cooperative group research efforts in thoracic malignancies 2009: a review from the 10th Annual International Lung Cancer Congress.
Clinical lung cancer 2009;10(6):395-404.
2009: Sangha Randeep; Lara Primo N; Adjei Alex A; Baas Paul; Choy Hak; Gaspar Laurie E; Goss Glenwood; Saijo Nagahiro; Schiller Joan H; Vokes Everett E; Gandara David R
Cooperative group research endeavors in small-cell lung cancer: current and future directions.
Clinical lung cancer 2009;10(5):322-30.
2009: Matsumoto Kazuko; Arao Tokuzo; Tanaka Kaoru; Kaneda Hiroyasu; Kudo Kanae; Fujita Yoshihiko; Tamura Daisuke; Aomatsu Keiichi; Tamura Tomohide; Yamada Yasuhide; Saijo Nagahiro; Nishio Kazuto
mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells.
Cancer research 2009;69(18):7160-4.
2009: Mok Tony S; Wu Yi-Long; Thongprasert Sumitra; Yang Chih-Hsin; Chu Da-Tong; Saijo Nagahiro; Sunpaweravong Patrapim; Han Baohui; Margono Benjamin; Ichinose Yukito; Nishiwaki Yutaka; Ohe Yuichiro; Yang Jin-Ji; Chewaskulyong Busyamas; Jiang Haiyi; Duffield Emma L; Watkins Claire L; Armour Alison A; Fukuoka Masahiro
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma.
The New England journal of medicine 2009;361(10):947-57.
2009: Kim Young Hak; Kubota Kaoru; Goto Koichi; Yoh Kiyotaka; Niho Seiji; Ohmatsu Hironobu; Saijo Nagahiro; Nishiwaki Yutaka
A phase I study of gemcitabine and carboplatin in patients with advanced non-small cell lung cancer and a performance status of 2.
Japanese journal of clinical oncology 2009;39(9):576-81.
2009: Mukohara Toru; Shimada Hiroyuki; Ogasawara Naomi; Wanikawa Ryoko; Shimomura Manami; Nakatsura Tetsuya; Ishii Genichiro; Park Joon Oh; Jänne Pasi A; Saijo Nagahiro; Minami Hironobu
Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression.
Cancer letters 2009;282(1):14-24.
2009: Sekine I; Ichinose Y; Nishiwaki Y; Yamamoto N; Tsuboi M; Nakagawa K; Shinkai T; Negoro S; Imamura F; Eguchi K; Takeda K; Itoh Y; Tamura T; Saijo N; Fukuoka M
Quality of life and disease-related symptoms in previously treated Japanese patients with non-small-cell lung cancer: results of a randomized phase III study (V-15-32) of gefitinib versus docetaxel.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2009;20(9):1483-8.
2009: Gandara David R; Kawaguchi Tomoya; Crowley John; Moon James; Furuse Kiyoyuki; Kawahara Masaaki; Teramukai Satoshi; Ohe Yuichiro; Kubota Kaoru; Williamson Stephen K; Gautschi Oliver; Lenz Heinz Josef; McLeod Howard L; Lara Primo N; Coltman Charles Arthur; Fukuoka Masahiro; Saijo Nagahiro; Fukushima Masanori; Mack Philip C
Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(21):3540-6.
2009: Yamamoto Nobuyuki; Sekine Ikuo; Nakagawa Kazuhiko; Takada Minoru; Fukuoka Masahiro; Tanigawara Yusuke; Saijo Nagahiro
A pharmacokinetic and dose escalation study of pegfilgrastim (KRN125) in lung cancer patients with chemotherapy-induced neutropenia.
Japanese journal of clinical oncology 2009;39(7):425-30.
2009: Kim Young Hak; Ishii Genichiro; Goto Koichi; Ota Shuji; Kubota Kaoru; Murata Yukinori; Mishima Michiaki; Saijo Nagahiro; Nishiwaki Yutaka; Ochiai Atsushi
Expression of breast cancer resistance protein is associated with a poor clinical outcome in patients with small-cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2009;65(1):105-11.
2009: Kusumoto Sojiro; Sugiyama Tomohide; Ando Koichi; Hosaka Takamichi; Ishida Hiroo; Shirai Takao; Yamaoka Toshimitsu; Okuda Kentaro; Hirose Takashi; Ohnishi Tsukasa; Inoue Fumiko; Kanome Tomoko; Kadofuku Tsuyoki; Saijo Nagahiro; Adachii Mitsuru; Ohmori Tohru
Combination effect between bortezomib and tumor necrosis factor alpha on gefitinib-resistant non-small cell lung cancer cell lines.
Anticancer research 2009;29(6):2315-22.
2009: Saijo Nagahiro; Takeuchi Masahiro; Kunitoh Hideo
Reasons for response differences seen in the V15-32, INTEREST and IPASS trials.
Nature reviews. Clinical oncology 2009;6(5):287-94.
2009: Matsubara Junichi; Ono Masaya; Negishi Ayako; Ueno Hideki; Okusaka Takuji; Furuse Junji; Furuta Koh; Sugiyama Emiko; Saito Yoshiro; Kaniwa Nahoko; Sawada Junichi; Honda Kazufumi; Sakuma Tomohiro; Chiba Tsutomu; Saijo Nagahiro; Hirohashi Setsuo; Yamada Tesshi
Identification of a predictive biomarker for hematologic toxicities of gemcitabine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(13):2261-8.
2009: Sekine Ikuo; Shimizu Chikako; Nishio Kazuto; Saijo Nagahiro; Tamura Tomohide
A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with breast cancer.
International journal of clinical oncology / Japan Society of Clinical Oncology 2009;14(2):112-9.
2009: Tsuboi Masahiro; Ezaki Kohji; Tobinai Kensei; Ohashi Yasuo; Saijo Nagahiro
Weekly administration of epoetin beta for chemotherapy-induced anemia in cancer patients: results of a multicenter, Phase III, randomized, double-blind, placebo-controlled study.
Japanese journal of clinical oncology 2009;39(3):163-8.
2009: Kunitoh H; Tamura T; Shibata T; Imai M; Nishiwaki Y; Nishio M; Yokoyama A; Watanabe K; Noda K; Saijo N;
A randomised trial of intrapericardial bleomycin for malignant pericardial effusion with lung cancer (JCOG9811).
British journal of cancer 2009;100(3):464-9.
2009: Saito Yoshiro; Sai Kimie; Maekawa Keiko; Kaniwa Nahoko; Shirao Kuniaki; Hamaguchi Tetsuya; Yamamoto Noboru; Kunitoh Hideo; Ohe Yuichiro; Yamada Yasuhide; Tamura Tomohide; Yoshida Teruhiko; Minami Hironobu; Ohtsu Atsushi; Matsumura Yasuhiro; Saijo Nagahiro; Sawada Jun-Ichi
Close association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 haplotype and its apparent influence on 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronidation in Japanese.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(2):272-6.
2009: Tatewaki Naoko; Maekawa Keiko; Katori Noriko; Kurose Kouichi; Kaniwa Nahoko; Yamamoto Noboru; Kunitoh Hideo; Ohe Yuichiro; Nokihara Hiroshi; Sekine Ikuo; Tamura Tomohide; Yoshida Teruhiko; Saijo Nagahiro; Saito Yoshiro; Sawada Jun-ichi
Genetic variations and haplotype structures of the glutathione S-transferase genes, GSTT1 and GSTM1, in a Japanese patient population.
Drug metabolism and pharmacokinetics 2009;24(1):118-26.
2008: Kubota Kaoru; Nishiwaki Yutaka; Tamura Tomohide; Nakagawa Kazuhiko; Matsui Kaoru; Watanabe Koshiro; Hida Toyoaki; Kawahara Masaaki; Katakami Nobuyuki; Takeda Koji; Yokoyama Akira; Noda Kazumasa; Fukuoka Masahiro; Saijo Nagahiro
Efficacy and safety of erlotinib monotherapy for Japanese patients with advanced non-small cell lung cancer: a phase II study.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(12):1439-45.
2008: Yoh Kiyotaka; Nishiwaki Yutaka; Ishii Genichiro; Goto Koichi; Kubota Kaoru; Ohmatsu Hironobu; Niho Seiji; Nagai Kanji; Saijo Nagahiro
Mutational status of EGFR and KIT in thymoma and thymic carcinoma.
Lung cancer (Amsterdam, Netherlands) 2008;62(3):316-20.
2008: Kim Young Hak; Goto Koichi; Yoh Kiyotaka; Niho Seiji; Ohmatsu Hironobu; Kubota Kaoru; Saijo Nagahiro; Nishiwaki Yutaka
Performance status and sensitivity to first-line chemotherapy are significant prognostic factors in patients with recurrent small cell lung cancer receiving second-line chemotherapy.
Cancer 2008;113(9):2518-23.
2008: Saijo Nagahiro
Population differences in the use of EGFR-targeted agents.
Clinical advances in hematology & oncology : H&O 2008;6(10):730-2.
2008: Saijo Nagahiro
Advances in the treatment of non-small cell lung cancer.
Cancer treatment reviews 2008;34(6):521-6.
2008: Maruyama Riichiroh; Nishiwaki Yutaka; Tamura Tomohide; Yamamoto Nobuyuki; Tsuboi Masahiro; Nakagawa Kazuhiko; Shinkai Tetsu; Negoro Shunichi; Imamura Fumio; Eguchi Kenji; Takeda Koji; Inoue Akira; Tomii Keisuke; Harada Masao; Masuda Noriyuki; Jiang Haiyi; Itoh Yohji; Ichinose Yukito; Saijo Nagahiro; Fukuoka Masahiro
Phase III study, V-15-32, of gefitinib versus docetaxel in previously treated Japanese patients with non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(26):4244-52.
2008: Kunitoh H; Kato H; Tsuboi M; Asamura H; Tada H; Nagai K; Mitsudomi T; Koike T; Nakagawa K; Ichinose Y; Okada M; Shibata T; Saijo N;
A randomised phase II trial of preoperative chemotherapy of cisplatin-docetaxel or docetaxel alone for clinical stage IB/II non-small-cell lung cancer results of a Japan Clinical Oncology Group trial (JCOG 0204).
British journal of cancer 2008;99(6):852-7.
2008: Kawai Osamu; Ishii Genichiro; Kubota Kaoru; Murata Yukinori; Naito Yoichi; Mizuno Tetsuya; Aokage Keiju; Saijo Nagahiro; Nishiwaki Yutaka; Gemma Akihiko; Kudoh Syoji; Ochiai Atsushi
Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer.
Cancer 2008;113(6):1387-95.
2008: Sai Kimie; Saito Yoshiro; Fukushima-Uesaka Hiromi; Kurose Koichi; Kaniwa Nahoko; Kamatani Naoyuki; Shirao Kuniaki; Yamamoto Noboru; Hamaguchi Tetsuya; Kunitoh Hideo; Ohe Yuichiro; Tamura Tomohide; Yamada Yasuhide; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Sawada Jun-ichi
Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients.
Cancer chemotherapy and pharmacology 2008;62(3):529-37.
2008: Niho Seiji; Kubota Kaoru; Yoh Kiyotaka; Goto Koichi; Ohmatsu Hironobu; Nihei Keiji; Saijo Nagahiro; Nishiwaki Yutaka
Clinical outcome of chemoradiation therapy in patients with limited-disease small cell lung cancer with ipsilateral pleural effusion.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(7):723-7.
2008: Ohe Yuichiro; Ichinose Yukito; Nakagawa Kazuhiko; Tamura Tomohide; Kubota Kaoru; Yamamoto Nobuyuki; Adachi Susumu; Nambu Yoshihiro; Fujimoto Toshio; Nishiwaki Yutaka; Saijo Nagahiro; Fukuoka Masahiro
Efficacy and safety of two doses of pemetrexed supplemented with folic acid and vitamin B12 in previously treated patients with non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(13):4206-12.
2008: Naito Yoichi; Kubota Kaoru; Nihei Keiji; Fujii Tomonori; Yoh Kiyotaka; Niho Seiji; Goto Koichi; Ohmatsu Hironobu; Saijo Nagahiro; Nishiwaki Yutaka
Concurrent chemoradiotherapy with cisplatin and vinorelbine for stage III non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(6):617-22.
2008: Saijo Nagahiro; Miki Tsuneharu; Kubota Yoshinobu; Naito Seiji; Akaza Hideyuki; Takahashi Shunji; Minami Hironobu
Report from the second Japanese Urological Association-Japanese Society of Medical Oncology joint conference, 2007: 'diagnosis and treatment of urological malignant tumors: how can we promote subspecialists?'.
International journal of urology : official journal of the Japanese Urological Association 2008;15(5):389-93.
2008: Nakagawa Kazuhiko; Yamazaki Koichi; Kunitoh Hideo; Hida Toyoaki; Gemba Kenichi; Shinkai Tetsu; Ichinose Yukito; Adachi Susumu; Nambu Yoshihiro; Saijo Nagahiro; Fukuoka Masahiro
Efficacy and safety of pemetrexed in combination with cisplatin for malignant pleural mesothelioma: a phase I/II study in Japanese patients.
Japanese journal of clinical oncology 2008;38(5):339-46.
2008: Kiura Katsuyuki; Nakagawa Kazuhiko; Shinkai Tetsu; Eguchi Kenji; Ohe Yuichiro; Yamamoto Nobuyuki; Tsuboi Masahiro; Yokota Soichiro; Seto Takashi; Jiang Haiyi; Nishio Kazuto; Saijo Nagahiro; Fukuoka Masahiro
A randomized, double-blind, phase IIa dose-finding study of Vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(4):386-93.
2008: Langer Corey J; Wakelee Heather; Schiller Joan; Choy Hak; Shepherd Frances; Vokes Everett E; Adjei Alex A; Baas Paul; Saijo Nagahiro; Gandara David R
Cooperative group portfolio in locally advanced non-small-cell lung cancer: are we making progress?
Clinical lung cancer 2008;9(2):85-91.
2008: Suzuki Yasuhiro; Tokuda Yutaka; Fujiwara Yasuhiro; Minami Hironobu; Ohashi Yasuo; Saijo Nagahiro
Weekly epoetin beta maintains haemoglobin levels and improves quality of life in patients with non-myeloid malignancies receiving chemotherapy.
Japanese journal of clinical oncology 2008;38(3):214-21.
2008: Sai Kimie; Saito Yoshiro; Sakamoto Hiromi; Shirao Kuniaki; Kurose Koichi; Saeki Mayumi; Ozawa Shogo; Kaniwa Nahoko; Hirohashi Setsuo; Saijo Nagahiro; Sawada Jun-ichi; Yoshida Teruhiko
Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients.
Cancer letters 2008;261(2):165-71.
2008: Kunitoh Hideo; Kato Harubumi; Tsuboi Masahiro; Shibata Taro; Asamura Hisao; Ichonose Yukito; Katakami Nobuyuki; Nagai Kanji; Mitsudomi Tetsuya; Matsumura Akihide; Nakagawa Ken; Tada Hirohito; Saijo Nagahiro;
Phase II trial of preoperative chemoradiotherapy followed by surgical resection in patients with superior sulcus non-small-cell lung cancers: report of Japan Clinical Oncology Group trial 9806.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(4):644-9.
2008: Wakelee Heather; Langer Corey; Vokes Everett; Schiller Joan; Baas Paul; Saijo Nagahiro; Adjei Alex; Shepherd Frances; Choy Hak; Gandara David R
Cooperative group research efforts in lung cancer: focus on early-stage non-small-cell lung cancer.
Clinical lung cancer 2008;9(1):9-15.
2008: Kim Su-Ryang; Saito Yoshiro; Maekawa Keiko; Sugiyama Emiko; Kaniwa Nahoko; Ueno Hideki; Okusaka Takuji; Ikeda Masafumi; Morizane Chigusa; Yamamoto Noboru; Yoshida Teruhiko; Kamatani Naoyuki; Furuse Junji; Ishii Hiroshi; Saijo Nagahiro; Ozawa Shogo; Sawada Jun-Ichi
Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK).
Drug metabolism and pharmacokinetics 2008;23(5):379-84.
2008: Sai Kimie; Saito Yoshiro; Itoda Masaya; Fukushima-Uesaka Hiromi; Nishimaki-Mogami Tomoko; Ozawa Shogo; Maekawa Keiko; Kurose Kouichi; Kaniwa Nahoko; Kawamoto Manabu; Kamatani Naoyuki; Shirao Kuniaki; Hamaguchi Tetsuya; Yamamoto Noboru; Kunitoh Hideo; Ohe Yuichiro; Yamada Yasuhide; Tamura Tomohide; Yoshida Teruhiko; Minami Hironobu; Matsumura Yasuhiro; Ohtsu Atsushi; Saijo Nagahiro; Sawada Jun-ichi
Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population.
Drug metabolism and pharmacokinetics 2008;23(2):139-47.
2008: Sekine Ikuo; Sumi Minako; Saijo Nagahiro
Local control of regional and metastatic lesions and indication for systemic chemotherapy in patients with non-small cell lung cancer.
The oncologist 2008;13 Suppl 1():21-7.
2007: Ukaji Maho; Saito Yoshiro; Fukushima-Uesaka Hiromi; Maekawa Keiko; Katori Noriko; Kaniwa Nahoko; Yoshida Teruhiko; Nokihara Hiroshi; Sekine Ikuo; Kunitoh Hideo; Ohe Yuichiro; Yamamoto Noboru; Tamura Tomohide; Saijo Nagahiro; Sawada Jun-ichi
Genetic variations of VDR/NR1I1 encoding vitamin D receptor in a Japanese population.
Drug metabolism and pharmacokinetics 2007;22(6):462-7.
2007: Kim Su-Ryang; Saito Yoshiro; Sai Kimie; Kurose Kouichi; Maekawa Keiko; Kaniwa Nahoko; Ozawa Shogo; Kamatani Naoyuki; Shirao Kuniaki; Yamamoto Noboru; Hamaguchi Tetsuya; Kunitoh Hideo; Ohe Yuichiro; Yamada Yasuhide; Tamura Tomohide; Yoshida Teruhiko; Minami Hironobu; Ohtsu Atsushi; Saijo Nagahiro; Sawada Jun-ichi
Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B1*17 is more prevalent than *15.
Drug metabolism and pharmacokinetics 2007;22(6):456-61.
2007: Yoshida Kimihide; Sugiura Takahiko; Takifuji Nobuhide; Kawahara Masaaki; Matsui Kaoru; Kudoh Shinzoh; Takada Minoru; Fukuoka Masahiro; Ariyoshi Yutaka; Fukuda Haruhiko; Saijo Nagahiro
Randomized phase II trial of three intrapleural therapy regimens for the management of malignant pleural effusion in previously untreated non-small cell lung cancer: JCOG 9515.
Lung cancer (Amsterdam, Netherlands) 2007;58(3):362-8.
2007: Kim Su-Ryang; Sai Kimie; Tanaka-Kagawa Toshiko; Jinno Hideto; Ozawa Shogo; Kaniwa Nahoko; Saito Yoshiro; Akasawa Akira; Matsumoto Kenji; Saito Hirohisa; Kamatani Naoyuki; Shirao Kuniaki; Yamamoto Noboru; Yoshida Teruhiko; Minami Hironobu; Ohtsu Atsushi; Saijo Nagahiro; Sawada Jun-ichi
Haplotypes and a novel defective allele of CES2 found in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1865-72.
2007: Yoh Kiyotaka; Kubota Kaoru; Kakinuma Ryutaro; Ohmatsu Hironobu; Goto Koichi; Niho Seiji; Saijo Nagahiro; Nishiwaki Yutaka
Phase II trial of carboplatin and paclitaxel in non-small cell lung cancer patients previously treated with chemotherapy.
Lung cancer (Amsterdam, Netherlands) 2007;58(1):73-9.
2007: Sekine Ikuo; Nokihara Hiroshi; Yamamoto Noboru; Kunitoh Hideo; Ohe Yuichiro; Saijo Nagahiro; Tamura Tomohide
Problems with registration-directed clinical trials for lung cancer in Japan.
The Tohoku journal of experimental medicine 2007;213(1):17-23.
2007: Sakai Kazuko; Yokote Hideyuki; Murakami-Murofushi Kimiko; Tamura Tomohide; Saijo Nagahiro; Nishio Kazuto
Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway.
Cancer science 2007;98(9):1498-503.
2007: Niho Seiji; Fujii Hirofumi; Murakami Koji; Nagase Seisuke; Yoh Kiyotaka; Goto Koichi; Ohmatsu Hironobu; Kubota Kaoru; Sekiguchi Ryuzo; Nawano Shigeru; Saijo Nagahiro; Nishiwaki Yutaka
Detection of unsuspected distant metastases and/or regional nodes by FDG-PET [corrected] scan in apparent limited-disease small-cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2007;57(3):328-33.
2007: Hosaka Takamichi; Inoue Fumiko; Ando Koichi; Ishida Hiroo; Kusumoto Sojiro; Sugiyama Tomohide; Shirai Takao; Okuda Kentaro; Hirose Takashi; Ohnishi Tsukasa; Horichi Naoya; Saijo Nagahiro; Adachi Mitsuru; Nakadate Toshio; Kuroki Toshio; Ohmori Tohru
Mutant epidermal growth factor receptor undergoes less protein degradation due to diminished binding to c-Cbl.
Anticancer research 2007;27(4B):2253-63.
2007: Minami Hironobu; Sai Kimie; Saeki Mayumi; Saito Yoshiro; Ozawa Shogo; Suzuki Kazuhiro; Kaniwa Nahoko; Sawada Jun-ichi; Hamaguchi Tetsuya; Yamamoto Noboru; Shirao Kuniaki; Yamada Yasuhide; Ohmatsu Hironobu; Kubota Kaoru; Yoshida Teruhiko; Ohtsu Atsushi; Saijo Nagahiro
Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28.
Pharmacogenetics and genomics 2007;17(7):497-504.
2007: Saito Yoshiro; Katori Noriko; Soyama Akiko; Nakajima Yukiko; Yoshitani Takashi; Kim Su-Ryang; Fukushima-Uesaka Hiromi; Kurose Kouichi; Kaniwa Nahoko; Ozawa Shogo; Kamatani Naoyuki; Komamura Kazuo; Kamakura Shiro; Kitakaze Masafumi; Tomoike Hitonobu; Sugai Kenji; Minami Narihiro; Kimura Hideo; Goto Yu-ichi; Minami Hironobu; Yoshida Teruhiko; Kunitoh Hideo; Ohe Yuichiro; Yamamoto Noboru; Tamura Tomohide; Saijo Nagahiro; Sawada Jun-ichi
CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population.
Pharmacogenetics and genomics 2007;17(7):461-71.
2007: Sekine Ikuo; Minna John D; Nishio Kazuto; Saijo Nagahiro; Tamura Tomohide
Genes regulating the sensitivity of solid tumor cell lines to cytotoxic agents: a literature review.
Japanese journal of clinical oncology 2007;37(5):329-36.
2007: Takeda Masayuki; Arao Tokuzo; Yokote Hideyuki; Komatsu Teruo; Yanagihara Kazuyoshi; Sasaki Hiroki; Yamada Yasuhide; Tamura Tomohide; Fukuoka Kazuya; Kimura Hiroshi; Saijo Nagahiro; Nishio Kazuto
AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):3051-7.
2007: Yoh Kiyotaka; Niho Seiji; Goto Koichi; Ohmatsu Hironobu; Kubota Kaoru; Kakinuma Ryutaro; Saijo Nagahiro; Nishiwaki Yutaka
Randomized trial of drip infusion versus bolus injection of vinorelbine for the control of local venous toxicity.
Lung cancer (Amsterdam, Netherlands) 2007;55(3):337-41.
2007: Ohe Y; Ohashi Y; Kubota K; Tamura T; Nakagawa K; Negoro S; Nishiwaki Y; Saijo N; Ariyoshi Y; Fukuoka M
Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(2):317-23.
2007: Kadowaki Shigenori; Tahara Makoto; Saijo Nagahiro
[The palliative care in the clinical oncology]
Nippon rinsho. Japanese journal of clinical medicine 2007;65(1):5-10.
2007: Sugiyama Emiko; Kaniwa Nahoko; Kim Su-Ryang; Kikura-Hanajiri Ruri; Hasegawa Ryuichi; Maekawa Keiko; Saito Yoshiro; Ozawa Shogo; Sawada Jun-ichi; Kamatani Naoyuki; Furuse Junji; Ishii Hiroshi; Yoshida Teruhiko; Ueno Hideki; Okusaka Takuji; Saijo Nagahiro
Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(1):32-42.
2007: Maekawa Keiko; Saeki Mayumi; Saito Yoshiro; Ozawa Shogo; Kurose Kouichi; Kaniwa Nahoko; Kawamoto Manabu; Kamatani Naoyuki; Kato Ken; Hamaguchi Tetsuya; Yamada Yasuhide; Shirao Kuniaki; Shimada Yasuhiro; Muto Manabu; Doi Toshihiko; Ohtsu Atsushi; Yoshida Teruhiko; Matsumura Yasuhiro; Saijo Nagahiro; Sawada Jun-ichi
Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences.
Journal of human genetics 2007;52(10):804-19.
2006: Kim Su-Ryang; Ozawa Shogo; Saito Yoshiro; Kurose Kouichi; Kaniwa Nahoko; Kamatani Naoyuki; Hamaguchi Tetsuya; Shirao Kuniaki; Muto Manabu; Ohtsu Atsushi; Yoshida Teruhiko; Matsumura Yasuhiro; Saijo Nagahiro; Sawada Jun-ichi
Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS).
Drug metabolism and pharmacokinetics 2006;21(6):509-16.
2006: Wislez Marie; Beer David G; Wistuba Ignacio; Cadranel Jacques; Saijo Nagahiro; Johnson Bruce E
Molecular biology, genomics, and proteomics in bronchioloalveolar carcinoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(9 Suppl):S8-12.
2006: Tamura Tomohide; Minami Hironobu; Yamada Yasuhide; Yamamoto Noboru; Shimoyama Tatsu; Murakami Haruyasu; Horiike Atsushi; Fujisaka Yasuhito; Shinkai Tetsu; Tahara Makoto; Kawada Kenji; Ebi Hiromichi; Sasaki Yasutsuna; Jiang Haiyi; Saijo Nagahiro
A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(9):1002-9.
2006: Saijo Takamoto; Ishii Genichiro; Ochiai Atsushi; Yoh Kiyotaka; Goto Koichi; Nagai Kanji; Kato Harubumi; Nishiwaki Yutaka; Saijo Nagahiro
Eg5 expression is closely correlated with the response of advanced non-small cell lung cancer to antimitotic agents combined with platinum chemotherapy.
Lung cancer (Amsterdam, Netherlands) 2006;54(2):217-25.
2006: Sekine Ikuo; Nokihara Hiroshi; Sumi Minako; Saijo Nagahiro; Nishiwaki Yutaka; Ishikura Satoshi; Mori Kiyoshi; Tsukiyama Iwao; Tamura Tomohide
Docetaxel consolidation therapy following cisplatin, vinorelbine, and concurrent thoracic radiotherapy in patients with unresectable stage III non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(8):810-5.
2006: Morishima Yasuo; Ogura Michinori; Yoneda Shuichi; Sakai Hiroshi; Tobinai Kensei; Nishiwaki Yutaka; Minami Hironobu; Hotta Tomomitsu; Ezaki Kohji; Ohe Yuichiro; Yokoyama Akira; Tsuboi Masahiro; Mori Kiyoshi; Watanabe Koshiro; Ohashi Yasuo; Hirashima Kunitake; Saijo Nagahiro;
Once-weekly epoetin-beta improves hemoglobin levels in cancer patients with chemotherapy-induced anemia: A randomized, double-blind, dose-finding study.
Japanese journal of clinical oncology 2006;36(10):655-61.
2006: Sai K; Itoda M; Saito Y; Kurose K; Katori N; Kaniwa N; Komamura K; Kotake T; Morishita H; Tomoike H; Kamakura S; Kitakaze M; Tamura T; Yamamoto N; Kunitoh H; Yamada Y; Ohe Y; Shimada Y; Shirao K; Minami H; Ohtsu A; Yoshida T; Saijo N; Kamatani N; Ozawa S; Sawada J
Genetic variations and haplotype structures of the ABCB1 gene in a Japanese population: an expanded haplotype block covering the distal promoter region, and associated ethnic differences.
Annals of human genetics 2006;70(Pt 5):605-22.
2006: Fujisaka Yasuhito; Tamura Tomohide; Ohe Yuichiro; Kunitoh Hideo; Sekine Ikuo; Yamamoto Noboru; Nokihara Hiroshi; Horiike Atsushi; Kodama Tetsuro; Saijo Nagahiro
Pharmacokinetics and pharmacodynamics of weekly epoetin beta in lung cancer patients.
Japanese journal of clinical oncology 2006;36(8):477-82.
2006: Nakajima Yukiko; Yoshitani Takashi; Fukushima-Uesaka Hiromi; Saito Yoshiro; Kaniwa Nahoko; Kurose Kouichi; Ozawa Shogo; Aoyagi Nobuo; Kamatani Naoyuki; Yamamoto Noboru; Kunitoh Hideo; Ohe Yuichiro; Tamura Tomohide; Yoshida Teruhiko; Minami Hironobu; Saijo Nagahiro; Katori Noriko; Sawada Jun-ichi
Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer.
Clinical pharmacology and therapeutics 2006;80(2):179-91.
2006: Sekine Ikuo; Nokihara Hiroshi; Yamamoto Noboru; Kunitoh Hideo; Ohe Yuichiro; Saijo Nagahiro; Tamura Tomohide
Common arm analysis: one approach to develop the basis for global standardization in clinical trials of non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2006;53(2):157-64.
2006: Sakai Kazuko; Yokote Hideyuki; Murakami-Murofushi Kimiko; Tamura Tomohide; Saijo Nagahiro; Nishio Kazuto
In-frame deletion in the EGF receptor alters kinase inhibition by gefitinib.
The Biochemical journal 2006;397(3):537-43.
2006: Sekine Ikuo; Sumi Minako; Ito Yoshinori; Nokihara Hiroshi; Yamamoto Noboru; Kunitoh Hideo; Ohe Yuichiro; Kodama Tetsuro; Saijo Nagahiro; Tamura Tomohide
Retrospective analysis of steroid therapy for radiation-induced lung injury in lung cancer patients.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2006;80(1):93-7.
2006: Shimoyama Tatsu; Koizumi Fumiaki; Fukumoto Hisao; Kiura Katsuyuki; Tanimoto Mitsune; Saijo Nagahiro; Nishio Kazuto
Effects of different combinations of gefitinib and irinotecan in lung cancer cell lines expressing wild or deletional EGFR.
Lung cancer (Amsterdam, Netherlands) 2006;53(1):13-21.
2006: Kim Su-Ryang; Saito Yoshiro; Maekawa Keiko; Sugiyama Emiko; Kaniwa Nahoko; Ueno Hideki; Okusaka Takuji; Morizane Chigusa; Yamamoto Noboru; Ikeda Masafumi; Yoshida Teruhiko; Minami Hironobu; Furuse Junji; Ishii Hiroshi; Saijo Nagahiro; Kamatani Naoyuki; Ozawa Shogo; Sawada Jun-ichi
Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleoside transporter 1 (hENT1).
Drug metabolism and pharmacokinetics 2006;21(3):248-56.
2006: Saijo Nagahiro
Recent trends in the treatment of advanced lung cancer.
Cancer science 2006;97(6):448-52.
2006: Niho Seiji; Goto Koichi; Yoh Kiyotaka; Kim Young Hak; Ohmatsu Hironobu; Kubota Kaoru; Saijo Nagahiro; Nishiwaki Yutaka
Interstitial shadow on chest CT is associated with the onset of interstitial lung disease caused by chemotherapeutic drugs.
Japanese journal of clinical oncology 2006;36(5):269-73.
2006: Ohtsu Atsushi; Yoshida Shigeaki; Saijo Nagahiro
Disparities in gastric cancer chemotherapy between the East and West.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(14):2188-96.
2006: Olopade Olufunmilayo I; Schwartsmann Gilberto; Saijo Nagahiro; Thomas Charles R
Disparities in cancer care: a worldwide perspective and roadmap for change.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(14):2135-6.
2006: Maekawa Keiko; Itoda Masaya; Sai Kimie; Saito Yoshiro; Kaniwa Nahoko; Shirao Kuniaki; Hamaguchi Tetsuya; Kunitoh Hideo; Yamamoto Noboru; Tamura Tomohide; Minami Hironobu; Kubota Kaoru; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Kamatani Naoyuki; Ozawa Shogo; Sawada Jun-ichi
Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population.
Drug metabolism and pharmacokinetics 2006;21(2):109-21.
2006: Watanabe Hirokazu; Kunitoh Hideo; Yamamoto Seiichiro; Kawasaki Shin; Inoue Akira; Hotta Katsuyuki; Shiomi Kazu; Kusumoto Masahiko; Sugimura Kazuro; Saijo Nagahiro
Effect of the introduction of minimum lesion size on interobserver reproducibility using RECIST guidelines in non-small cell lung cancer patients.
Cancer science 2006;97(3):214-8.
2006: Edelman Martin J; Sekine Ikuo; Tamura Tomohide; Saijo Nagahiro
Geographic variation in the second-line treatment of non-small cell lung cancer.
Seminars in oncology 2006;33(1 Suppl 1):S39-44.
2006: Sakai Kazuko; Arao Tokuzo; Shimoyama Tatsu; Murofushi Kimiko; Sekijima Masaru; Kaji Naoko; Tamura Tomohide; Saijo Nagahiro; Nishio Kazuto
Dimerization and the signal transduction pathway of a small in-frame deletion in the epidermal growth factor receptor.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(2):311-3.
2006: Sekine Ikuo; Minna John D; Nishio Kazuto; Tamura Tomohide; Saijo Nagahiro
A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(1):31-7.
2006: Niho Seiji; Kubota Kaoru; Goto Koichi; Yoh Kiyotaka; Ohmatsu Hironobu; Kakinuma Ryutaro; Saijo Nagahiro; Nishiwaki Yutaka
First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer: a phase II study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(1):64-9.
2006: Saeki M; Saito Y; Jinno H; Sai K; Ozawa S; Kurose K; Kaniwa N; Komamura K; Kotake T; Morishita H; Kamakura S; Kitakaze M; Tomoike H; Shirao K; Tamura T; Yamamoto N; Kunitoh H; Hamaguchi T; Yoshida T; Kubota K; Ohtsu A; Muto M; Minami H; Saijo N; Kamatani N; Sawada J-I
Haplotype structures of the UGT1A gene complex in a Japanese population.
The pharmacogenomics journal 2006;6(1):63-75.
2005: Ando Koichi; Ohmori Tohru; Inoue Fumiko; Kadofuku Tsuyoki; Hosaka Takamichi; Ishida Hiroo; Shirai Takao; Okuda Kentaro; Hirose Takashi; Horichi Naoya; Nishio Kazuto; Saijo Nagahiro; Adachi Mitsuru; Kuroki Toshio
Enhancement of sensitivity to tumor necrosis factor alpha in non-small cell lung cancer cells with acquired resistance to gefitinib.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(24 Pt 1):8872-9.
2005: Kiura Katsuyuki; Saijo Nagahiro
Can dose-dense chemotherapy improve outcome in patients with better-prognosis small-cell lung cancer?
Nature clinical practice. Oncology 2005;2(12):610-1.
2005: Nishio Kazuto; Arao Tokuzo; Shimoyama Tatsu; Fujiwara Yasuhiro; Tamura Tomohide; Saijo Nagahiro
Translational studies for target-based drugs.
Cancer chemotherapy and pharmacology 2005;56 Suppl 1():90-3.
2005: Saijo Nagahiro
Is radiotherapy optimally combined with chemotherapy in elderly patients with limited-stage small-cell lung cancer?
Nature clinical practice. Oncology 2005;2(11):550-1.
2005: Akaza Hideyuki; Tsuruo Takashi; Saijo Nagahiro; Sone Saburo; Isonishi Seiji; Ohashi Yasuo; Noguchi Shinzaburo; Kurebayashi Junichi; Kakehi Yoshiyuki; Ishikawa Hideki; Blackledge George
[Cancer prevention]
Gan to kagaku ryoho. Cancer & chemotherapy 2005;32(10):1499-506.
2005: Kubo Takashi; Kim Su-Ryang; Sai Kimie; Saito Yoshiro; Nakajima Toshiharu; Matsumoto Kenji; Saito Hirohisa; Shirao Kuniaki; Yamamoto Noboru; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Ohno Yasuo; Ozawa Shogo; Sawada Jun-Ichi
Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2).
Drug metabolism and disposition: the biological fate of chemicals 2005;33(10):1482-7.
2005: Ikeda Shinobu; Kurose Kouichi; Jinno Hideto; Sai Kimie; Ozawa Shogo; Hasegawa Ryuichi; Komamura Kazuo; Kotake Takeshi; Morishita Hideki; Kamakura Shiro; Kitakaze Masafumi; Tomoike Hitonobu; Tamura Tomohide; Yamamoto Noboru; Kunitoh Hideo; Yamada Yasuhide; Ohe Yuichiro; Shimada Yasuhiro; Shirao Kuniaki; Kubota Kaoru; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Saito Yoshiro; Sawada Jun-ichi
Functional analysis of four naturally occurring variants of human constitutive androstane receptor.
Molecular genetics and metabolism 2005;86(1-2):314-9.
2005: Kubota Kaoru; Nishiwaki Yutaka; Sugiura Takahiko; Noda Kazumasa; Mori Kiyoshi; Kawahara Masaaki; Negoro Shunichi; Watanabe Koshiro; Imamura Fumio; Tamura Tomohide; Saijo Nagahiro
Pilot study of concurrent etoposide and cisplatin plus accelerated hyperfractionated thoracic radiotherapy followed by irinotecan and cisplatin for limited-stage small cell lung cancer: Japan Clinical Oncology Group 9903.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5534-8.
2005: Yamazaki Shigeo; Sekine Ikuo; Matsuno Yoshihiro; Takei Hidefumi; Yamamoto Noboru; Kunitoh Hideo; Ohe Yuichiro; Tamura Tomohide; Kodama Tetsuro; Asamura Hisao; Tsuchiya Ryosuke; Saijo Nagahiro
Clinical responses of large cell neuroendocrine carcinoma of the lung to cisplatin-based chemotherapy.
Lung cancer (Amsterdam, Netherlands) 2005;49(2):217-23.
2005: Koyano Satoru; Saito Yoshiro; Fukushima-Uesaka Hiromi; Ishida Seiichi; Ozawa Shogo; Kamatani Naoyuki; Minami Hironobu; Ohtsu Atsushi; Hamaguchi Tetsuya; Shirao Kuniaki; Yoshida Teruhiko; Saijo Nagahiro; Jinno Hideto; Sawada Jun-Ichi
Functional analysis of six human aryl hydrocarbon receptor variants in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1254-60.
2005: Koizumi Fumiaki; Shimoyama Tatsu; Taguchi Fumiko; Saijo Nagahiro; Nishio Kazuto
Establishment of a human non-small cell lung cancer cell line resistant to gefitinib.
International journal of cancer. Journal international du cancer 2005;116(1):36-44.
2005: Saijo Nagahiro
What phase III trials are needed to improve the treatment of advanced non-small-cell lung cancer?
Nature clinical practice. Oncology 2005;2(6):275.
2005: Saijo Nagahiro; Nimura Yuji
Summary of the ASCO-JSCO joint symposium.
International journal of clinical oncology / Japan Society of Clinical Oncology 2005;10(3):153-6.
2005: Hichiya Hiroyuki; Tanaka-Kagawa Toshiko; Soyama Akiko; Jinno Hideto; Koyano Satoru; Katori Noriko; Matsushima Erika; Uchiyama Shigehisa; Tokunaga Hiroshi; Kimura Hideo; Minami Narihiro; Katoh Masaaki; Sugai Kenji; Goto Yu-ichi; Tamura Tomohide; Yamamoto Noboru; Ohe Yuichiro; Kunitoh Hideo; Nokihara Hiroshi; Yoshida Teruhiko; Minami Hironobu; Saijo Nagahiro; Ando Masanori; Ozawa Shogo; Saito Yoshiro; Sawada Jun-ichi
Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(5):630-6.
2005: Saeki Mayumi; Saito Yoshiro; Jinno Hideto; Sai Kimie; Hachisuka Akiko; Kaniwa Nahoko; Ozawa Shogo; Kawamoto Manabu; Kamatani Naoyuki; Shirao Kuniaki; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Komamura Kazuo; Kotake Takeshi; Morishita Hideki; Kamakura Shiro; Kitakaze Masafumi; Tomoike Hitonobu; Sawada Jun-ichi
Genetic variations and haplotypes of UGT1A4 in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(2):144-51.
2005: Atagi Shinji; Kawahara Masaaki; Tamura Tomohide; Noda Kazumasa; Watanabe Koshiro; Yokoyama Akira; Sugiura Takahiko; Senba Hiroshi; Ishikura Satoshi; Ikeda Hiroshi; Ishizuka Naoki; Saijo Nagahiro;
Standard thoracic radiotherapy with or without concurrent daily low-dose carboplatin in elderly patients with locally advanced non-small cell lung cancer: a phase III trial of the Japan Clinical Oncology Group (JCOG9812).
Japanese journal of clinical oncology 2005;35(4):195-201.
2005: Yonemori Kan; Ueno Hideki; Okusaka Takuji; Yamamoto Noboru; Ikeda Masafumi; Saijo Nagahiro; Yoshida Teruhiko; Ishii Hiroshi; Furuse Junji; Sugiyama Emiko; Kim Su-Ryang; Kikura-Hanajiri Ruri; Hasegawa Ryuichi; Saito Yoshiro; Ozawa Shogo; Kaniwa Nahoko; Sawada Jun-Ichi
Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2620-4.
2005: Ohe Y; Negoro S; Matsui K; Nakagawa K; Sugiura T; Takada Y; Nishiwaki Y; Yokota S; Kawahara M; Saijo N; Fukuoka M; Ariyoshi Y
Phase I-II study of amrubicin and cisplatin in previously untreated patients with extensive-stage small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16(3):430-6.
2005: Saeki Mayumi; Saito Yoshiro; Jinno Hideto; Sai Kimie; Kaniwa Nahoko; Ozawa Shogo; Komamura Kazuo; Kotake Takeshi; Morishita Hideki; Kamakura Shiro; Kitakaze Masafumi; Tomoike Hitonobu; Shirao Kuniaki; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Kamatani Naoyuki; Sawada Jun-ichi
Genetic polymorphisms of UGT1A6 in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(1):85-90.
2005: Koyano Satoru; Saito Yoshiro; Sai Kimie; Kurose Kouichi; Ozawa Shogo; Nakajima Toshiharu; Matsumoto Kenji; Saito Hirohisa; Shirao Kuniaki; Yoshida Teruhiko; Minami Hironobu; Ohtsu Atsushi; Saijo Nagahiro; Sawada Jun-ichi
Novel genetic polymorphisms in the NR3C1 (glucocorticoid receptor) gene in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(1):79-84.
2005: Yamamoto Noboru; Tamura Tomohide; Murakami Haruyasu; Shimoyama Tatsu; Nokihara Hiroshi; Ueda Yutaka; Sekine Ikuo; Kunitoh Hideo; Ohe Yuichiro; Kodama Tetsuro; Shimizu Mikiko; Nishio Kazuto; Ishizuka Naoki; Saijo Nagahiro
Randomized pharmacokinetic and pharmacodynamic study of docetaxel: dosing based on body-surface area compared with individualized dosing based on cytochrome P450 activity estimated using a urinary metabolite of exogenous cortisol.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(6):1061-9.
2005: Horiike Atsushi; Saijo Nagahiro
Small-cell lung cancer: current therapy and novel agents.
Oncology (Williston Park, N.Y.) 2005;19(1):47-52; discussion 52, 54-8.
2005: Akaza Hideyuki; Tsuruo Takashi; Saijo Nagahiro; Sone Saburo; Isonishi Seiji; Ohashi Yasuo; Sobue Tomotaka; Yamanaka Hidetoshi; Fukuda Mamoru; Maruyama Masakazu; Eguchi Kenji; Ito Kazuto; Smith Mark; Milsted Bob
[Cancer screening]
Gan to kagaku ryoho. Cancer & chemotherapy 2005;32(1):125-34.
2004: Arao Tokuzo; Fukumoto Hisao; Takeda Masayuki; Tamura Tomohide; Saijo Nagahiro; Nishio Kazuto
Small in-frame deletion in the epidermal growth factor receptor as a target for ZD6474.
Cancer research 2004;64(24):9101-4.
2004: Taguchi Fumiko; Koh Yasuhiro; Koizumi Fumiaki; Tamura Tomohide; Saijo Nagahiro; Nishio Kazuto
Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib ("Iressa")-sensitive and resistant xenograft models.
Cancer science 2004;95(12):984-9.
2004: Saijo Nagahiro
What are the reasons for negative phase III trials of molecular-target-based drugs?
Cancer science 2004;95(10):772-6.
2004: Park Jong-Kook; Lee Sang-Hak; Kang Jin-Hyoung; Nishio Kazuto; Saijo Nagahiro; Kuh Hyo-Jeong
Synergistic interaction between gefitinib (Iressa, ZD1839) and paclitaxel against human gastric carcinoma cells.
Anti-cancer drugs 2004;15(8):809-18.
2004: Fukushima-Uesaka Hiromi; Sai Kimie; Maekawa Keiko; Koyano Satoru; Kaniwa Nahoko; Ozawa Shogo; Kawamoto Manabu; Kamatani Naoyuki; Komamura Kazuo; Kamakura Shiro; Kitakaze Masafumi; Tomoike Hitonobu; Ueno Kazuyuki; Minami Hironobu; Ohtsu Atsushi; Shirao Kuniaki; Yoshida Teruhiko; Saijo Nagahiro; Saito Yoshiro; Sawada Jun-ichi
Genetic variations of the AHR gene encoding aryl hydrocarbon receptor in a Japanese population.
Drug metabolism and pharmacokinetics 2004;19(4):320-6.
2004: Sekine Ikuo; Noda Kazumasa; Oshita Fumihiro; Yamada Kouzou; Tanaka Manabu; Yamashita Kosuke; Nokihara Hiroshi; Yamamoto Noboru; Kunitoh Hideo; Ohe Yuichiro; Tamura Tomohide; Kodama Tetsuro; Sumi Minako; Saijo Nagahiro
Phase I study of cisplatin, vinorelbine, and concurrent thoracic radiotherapy for unresectable stage III non-small cell lung cancer.
Cancer science 2004;95(8):691-5.
2004: Goto K; Sekine I; Nishiwaki Y; Kakinuma R; Kubota K; Matsumoto T; Ohmatsu H; Niho S; Kodama T; Shinkai T; Tamura T; Ohe Y; Kunitoh H; Yamamoto N; Nokihara H; Yoshida K; Sugiura T; Matsui K; Saijo N
Multi-institutional phase II trial of irinotecan, cisplatin, and etoposide for sensitive relapsed small-cell lung cancer.
British journal of cancer 2004;91(4):659-65.
2004: Fujisaka Yasuhito; Saijo Nagahiro
[International estimation of molecular target drug]
Nippon rinsho. Japanese journal of clinical medicine 2004;62(7):1225-31.
2004: Minami Hironobu; Ohe Yuichi; Niho Seiji; Goto Koichi; Ohmatsu Hironobu; Kubota Kaoru; Kakinuma Ryutaro; Nishiwaki Yutaka; Nokihara Hiroshi; Sekine Ikuo; Saijo Nagahiro; Hanada Kazuhiko; Ogata Hiroyasu
Comparison of pharmacokinetics and pharmacodynamics of docetaxel and Cisplatin in elderly and non-elderly patients: why is toxicity increased in elderly patients?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(14):2901-8.
2004: Takano Toshimi; Ohe Yuichiro; Kusumoto Masahiko; Tateishi Ukihide; Yamamoto Seiichiro; Nokihara Hiroshi; Yamamoto Noboru; Sekine Ikuo; Kunitoh Hideo; Tamura Tomohide; Kodama Tetsuro; Saijo Nagahiro
Risk factors for interstitial lung disease and predictive factors for tumor response in patients with advanced non-small cell lung cancer treated with gefitinib.
Lung cancer (Amsterdam, Netherlands) 2004;45(1):93-104.
2004: Saijo Nagahiro; Horiike Atsushi
Topoisomerase I inhibitors in small-cell lung cancer. The Japanese experience.
Oncology (Williston Park, N.Y.) 2004;18(7 Suppl 4):11-6.
2004: Sai Kimie; Saeki Mayumi; Saito Yoshiro; Ozawa Shogo; Katori Noriko; Jinno Hideto; Hasegawa Ryuichi; Kaniwa Nahoko; Sawada Jun-ichi; Komamura Kazuo; Ueno Kazuyuki; Kamakura Shiro; Kitakaze Masafumi; Kitamura Yutaka; Kamatani Naoyuki; Minami Hironobu; Ohtsu Atsushi; Shirao Kuniaki; Yoshida Teruhiko; Saijo Nagahiro
UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer.
Clinical pharmacology and therapeutics 2004;75(6):501-15.
2004: Sekine Ikuo; Yamamoto Noboru; Kunitoh Hideo; Ohe Yuichiro; Tamura Tomohide; Kodama Tetsuro; Saijo Nagahiro
Treatment of small cell lung cancer in the elderly based on a critical literature review of clinical trials.
Cancer treatment reviews 2004;30(4):359-68.
2004: Akaza Hideyuki; Nakagawa Masayuki; Tsuruo Takashi; Saijo Nagahiro; Sone Saburo; Yamamoto Nobuyuki; Kakeji Yoshihiro; Nakamura Seigo; Kurebayashi Junichi; Isonishi Seiji; Ohashi Yasuo; Blackledge George; Carmichael James
[Anti angiogenesis]
Gan to kagaku ryoho. Cancer & chemotherapy 2004;31(4):647-55.
2004: Sekine I; Nokihara H; Horiike A; Yamamoto N; Kunitoh H; Ohe Y; Tamura T; Kodama T; Saijo N
Phase I study of cisplatin analogue nedaplatin (254-S) and paclitaxel in patients with unresectable squamous cell carcinoma.
British journal of cancer 2004;90(6):1125-8.
2004: Taguchi Fumiko; Kusaba Hitoshi; Asai Akira; Iwamoto Yasuo; Yano Keiichi; Nakano Hirofumi; Mizukami Tamio; Saijo Nagahiro; Kato Harubumi; Nishio Kazuto
hnRNP L enhances sensitivity of the cells to KW-2189.
International journal of cancer. Journal international du cancer 2004;108(5):679-85.
2004: Akaza Hideyuki; Ichikawa Tomohiko; Tsuruo Takashi; Shimada Yasuhiro; Moriwaki Hisataka; Mori Masaki; Noguchi Shinzaburo; Nakamura Seigo; Saijo Nagahiro; Sone Saburo; Isonishi Seiji; Ohashi Yasuo; Hinotsu Shiro; von Euler Mikael; Blackedge George
[Molecule based diagnosis]
Gan to kagaku ryoho. Cancer & chemotherapy 2004;31(1):125-33.
2004: Ohe Y; Niho S; Kakinuma R; Kubota K; Ohmatsu H; Goto K; Nokihara H; Kunitoh H; Saijo N; Aono H; Watanabe K; Tango M; Yokoyama A; Nishiwaki Y
A phase II study of cisplatin and docetaxel administered as three consecutive weekly infusions for advanced non-small-cell lung cancer in elderly patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(1):45-50.
2004: Koizumi Fumiaki; Kanzawa Fumihiko; Ueda Yutaka; Koh Yasuhiro; Tsukiyama Shoji; Taguchi Fumiko; Tamura Tomohide; Saijo Nagahiro; Nishio Kazuto
Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ("Iressa") and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells.
International journal of cancer. Journal international du cancer 2004;108(3):464-72.
2003: Watanabe Hirokazu; Yamamoto Noboru; Tamura Tomohide; Shimoyama Tatsu; Hotta Katsuyuki; Inoue Akira; Sawada Masahiro; Akiyama Yoshiko; Kusaba Hitoshi; Nokihara Hiroshi; Sekine Ikuo; Kunitoh Hideo; Ohe Yuichiro; Kodama Tetsuro; Saijo Nagahiro
Study of paclitaxel and dose escalation of cisplatin in patients with advanced non-small cell lung cancer.
Japanese journal of clinical oncology 2003;33(12):626-30.
2003: Saijo N
Progress in treatment of small-cell lung cancer: role of CPT-11.
British journal of cancer 2003;89(12):2178-83.
2003: Sai Kimie; Kaniwa Nahoko; Itoda Masaya; Saito Yoshiro; Hasegawa Ryuichi; Komamura Kazuo; Ueno Kazuyuki; Kamakura Shiro; Kitakaze Masafumi; Shirao Kuniaki; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Kitamura Yutaka; Kamatani Naoyuki; Ozawa Shogo; Sawada Jun-Ichi
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan.
Pharmacogenetics 2003;13(12):741-57.
2003: Watanabe Hirokazu; Yamamoto Seiichiro; Kunitoh Hideo; Sekine Ikuo; Yamamoto Noboru; Ohe Yuichiro; Tamura Tomohide; Kodama Tetsuro; Sugimura Kazuro; Saijo Nagahiro
Tumor response to chemotherapy: the validity and reproducibility of RECIST guidelines in NSCLC patients.
Cancer science 2003;94(11):1015-20.
2003: Ando Yuichi; Ohtsu Tomoko; Ando Masahiko; Ohyanagi Fumiyoshi; Nagashima Fumio; Narabayashi Masaru; Saijo Nagahiro; Sasaki Yasutsuna
Re: Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001.
Journal of the National Cancer Institute 2003;95(21):1638-40.
2003: Takano Toshimi; Saijo Nagahiro
[Doctor-initiated clinical trials and the revised pharmaceutical affairs law]
Gan to kagaku ryoho. Cancer & chemotherapy 2003;30(10):1391-7.
2003: Nakamura Yoichi; Kunitoh Hideo; Kubota Kaoru; Sekine Ikuo; Yamamoto Noboru; Tamura Tomohide; Kodama Tetsuro; Saijo Nagahiro
Retrospective analysis of safety and efficacy of low-dose docetaxel 60 mg/m2 in advanced non-small cell lung cancer patients previously treated with platinum-based chemotherapy.
American journal of clinical oncology 2003;26(5):459-64.
2003: Yamanaka Ryuya; Akutagawa Shigeru; Taguchi Fumiko; Yajima Naoki; Tsuchiya Naoto; Uzuka Takeo; Morii Ken; Takahashi Hideaki; Tanaka Ryuichi; Saijo Nagahiro; Nishio Kazuto
Selection of surrogate marker genes in primary central nervous system lymphomas for radio-chemotherapy by DNA array analysis of gene expression profiles.
International journal of oncology 2003;23(4):913-23.
2003: Natsume Tsugitaka; Watanabe Jun-ichi; Koh Yasuhiro; Fujio Nami; Ohe Yuichiro; Horiuchi Toshi; Saijo Nagahiro; Nishio Kazuto; Kobayashi Motohiro
Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo.
Cancer science 2003;94(9):826-33.
2003: Saijo Nagahiro; Nishio Kazuto; Tamura Tomohide
Translational and clinical studies of target-based cancer therapy.
International journal of clinical oncology / Japan Society of Clinical Oncology 2003;8(4):187-92.
2003: Ohe Yuichiro; Ishizuka Naoki; Tamura Tomohide; Sekine Ikuo; Nishiwaki Yutaka; Saijo Nagahiro;
Long-term follow-up of patients with unresectable locally advanced non-small cell lung cancer treated with chemoradiotherapy: a retrospective analysis of the data from the Japan Clinical Oncology Group trials (JCOG0003A).
Cancer science 2003;94(8):729-34.
2003: Jinno Hideto; Saeki Mayumi; Saito Yoshiro; Tanaka-Kagawa Toshiko; Hanioka Nobumitsu; Sai Kimie; Kaniwa Nahoko; Ando Masanori; Shirao Kuniaki; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Ozawa Shogo; Sawada Jun-ichi
Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients.
The Journal of pharmacology and experimental therapeutics 2003;306(2):688-93.
2003: Saijo Nagahiro; Tamura Tomohide; Nishio Kazuto
Strategy for the development of novel anticancer drugs.
Cancer chemotherapy and pharmacology 2003;52 Suppl 1():S97-101.
2003: Tsunoda Takuya; Koh Yasuhiro; Koizumi Fumiaki; Tsukiyama Shoji; Ueda Hiroshi; Taguchi Fumiko; Yamaue Hiroki; Saijo Nagahiro; Nishio Kazuto
Differential gene expression profiles and identification of the genes relevant to clinicopathologic factors in colorectal cancer selected by cDNA array method in combination with principal component analysis.
International journal of oncology 2003;23(1):49-59.
2003: Shimizu Toshio; Saijo Nagahiro
[Common toxicity criteria: version 2.0, an improved reference for grading the adverse reaction of cancer treatment]
Nippon rinsho. Japanese journal of clinical medicine 2003;61(6):937-42.
2003: Kanzawa F; Akiyama Y; Saijo N; Nishio K
In vitro effects of combinations of cis-amminedichloro (2-methylpyridine) platinum (II) (ZD0473) with other novel anticancer drugs on the growth of SBC-3, a human small cell lung cancer cell line.
Lung cancer (Amsterdam, Netherlands) 2003;40(3):325-32.
2003: Sekine I; Nishiwaki Y; Noda K; Kudoh S; Fukuoka M; Mori K; Negoro S; Yokoyama A; Matsui K; Ohsaki Y; Nakano T; Saijo N;
Randomized phase II study of cisplatin, irinotecan and etoposide combinations administered weekly or every 4 weeks for extensive small-cell lung cancer (JCOG9902-DI).
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2003;14(5):709-14.
2003: Jinno Hideto; Saeki Mayumi; Tanaka-Kagawa Toshiko; Hanioka Nobumitsu; Saito Yoshiro; Ozawa Shogo; Ando Masanori; Shirao Kuniaki; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Sawada Jun-Ichi
Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(5):528-32.
2003: Akaza Hideyuki; Fukuoka Masahiro; Ohtsu Atsushi; Usami Michiyuki; Ikeda Tadashi; Aiba Keisuke; Isonishi Seiji; Ohashi Yasuo; Saijo Nagahiro; Sone Saburo; Tsukagoshi Shigeru; Tsuruo Takashi; Kato Masuhiro; Mikami Osamu; Dong Rui-Ping; von Euler Mikael; Blackledge George; Stribling Don
[Globalization of clinical trials]
Gan to kagaku ryoho. Cancer & chemotherapy 2003;30(4):555-65.
2003: Sekine I; Nishiwaki Y; Kakinuma R; Kubota K; Hojo F; Matsumoto T; Ohmatsu H; Goto K; Kodama T; Eguchi K; Shinkai T; Tamura T; Ohe Y; Kunitoh H; Yoshimura K; Saijo N
Phase I/II trial of weekly cisplatin, etoposide, and irinotecan chemotherapy for metastatic lung cancer: JCOG 9507.
British journal of cancer 2003;88(6):808-13.
2003: Usuda Jitsuo; Inomata Motoko; Fukumoto Hisao; Iwamoto Yasuo; Suzuki Toshihiro; Kuh Hyo-Jeong; Fukuoka Kazuya; Kato Harubumi; Saijo Nagahiro; Nishio Kazuto
Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells.
International journal of oncology 2003;22(1):81-6.
2003: Ikeda Shinobu; Kurose Kouichi; Ozawa Shogo; Sai Kimie; Hasegawa Ryuichi; Komamura Kazuo; Ueno Kazuyuki; Kamakura Shiro; Kitakaze Masafumi; Tomoike Hitonobu; Nakajima Toshiharu; Matsumoto Kenji; Saito Hirohisa; Goto Yu-Ichi; Kimura Hideo; Katoh Masaaki; Sugai Kenji; Minami Narihiro; Shirao Kuniaki; Tamura Tomohide; Yamamoto Noboru; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Saito Yoshiro; Sawada Jun-Ichi
Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population.
Drug metabolism and pharmacokinetics 2003;18(6):413-8.
2003: Kim Su-Ryang; Nakamura Takahiro; Saito Yoshiro; Sai Kimie; Nakajima Toshiharu; Saito Hirohisa; Shirao Kuniaki; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Ozawa Shogo; Sawada Jun-ichi
Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2).
Drug metabolism and pharmacokinetics 2003;18(5):327-32.
2003: Itoda Masaya; Saito Yoshiro; Shirao Kuniaki; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Suzuki Hiroshi; Sugiyama Yuichi; Ozawa Shogo; Sawada Jun-ichi
Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.
Drug metabolism and pharmacokinetics 2003;18(3):212-7.
2003: Saeki Mayumi; Saito Yoshiro; Jinno Hideto; Sai Kimie; Komamura Kazuo; Ueno Kazuyuki; Kamakura Shiro; Kitakaze Masafumi; Shirao Kuniaki; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Ozawa Shogo; Sawada Jun-ichi
Three novel single nucleotide polymorphisms in UGT1A9.
Drug metabolism and pharmacokinetics 2003;18(2):146-9.
2002: Murakami H; Tamura T; Yamada Y; Yamamoto N; Ueda Y; Shimoyama T; Saijo N
ZD0473 pharmacokinetics in Japanese patients: a Phase I dose-escalation study.
European journal of cancer (Oxford, England : 1990) 2002;38 Suppl 8():S1-5.
2002: Saijo Nagahiro
[Medical oncology in Japan]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2002;91(11):3143-6.
2002: Akaza Hideyuki; Ohashi Yasuo; Shimada Yasuhiro; Ikeda Tadashi; Saijo Nagahiro; Isonishi Seiji; Hirao Yoshihiko; Tsuruo Takashi; Tsukagoshi Shigeru; Sone Saburo; Nakamura Seigo; Kato Masuhiro; Mikami Osamu; von Euler Mikael; Blackledge George; Milsted Bob; Vose Brent
[Post launch studies]
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29(11):2037-48.
2002: Inoue Akira; Kunitoh Hideo; Mori Kiyoshi; Nukiwa Tohishiro; Fukuoka Masahiro; Saijo Nagahiro
Phase I trial of weekly docetaxel in elderly patients with non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2002;38(2):205-9.
2002: Saijo Nagahiro
Translational study in cancer research.
Internal medicine (Tokyo, Japan) 2002;41(10):770-3.
2002: Kawamura-Akiyama Yoshiko; Kusaba Hitoshi; Kanzawa Fumihiko; Tamura Tomohide; Saijo Nagahiro; Nishio Kazuto
Non-cross resistance of ZD0473 in acquired cisplatin-resistant lung cancer cell lines.
Lung cancer (Amsterdam, Netherlands) 2002;38(1):43-50.
2002: Sekine I; Yamamoto N; Kunitoh H; Ohe Y; Tamura T; Kodama T; Saijo N
Relationship between objective responses in phase I trials and potential efficacy of non-specific cytotoxic investigational new drugs.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13(8):1300-6.
2002: Takada Minoru; Fukuoka Masahiro; Kawahara Masaaki; Sugiura Takahiko; Yokoyama Akira; Yokota Soichiro; Nishiwaki Yutaka; Watanabe Koshiro; Noda Kazumasa; Tamura Tomohide; Fukuda Haruhiko; Saijo Nagahiro
Phase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small-cell lung cancer: results of the Japan Clinical Oncology Group Study 9104.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(14):3054-60.
2002: Ohira Tatsuo; Akutagawa Shigeru; Usuda Jitsuo; Nakamura Takashi; Hirano Takashi; Tsuboi Masahiro; Nishio Kazuto; Taguchi Fumiko; Ikeda Norihido; Nakamura Haruhiko; Konaka Chimori; Saijo Nagahiro; Kato Harubumi
Up-regulated gene expression of angiogenesis factors in post-chemotherapeutic lung cancer tissues determined by cDNA macroarray.
Oncology reports 2002;9(4):723-8.
2002: Ohe Yuichiro; Saijo Nagahiro
Results of recent Japanese clinical trials in lung cancer.
Clinical lung cancer 2002;3(4):243-8.
2002: Fujisaka Yasuhito; Saijo Nagahiro
[Growth factor induced signal transduction in lung cancer]
Nippon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 5():83-8.
2002: Kishi Yukiko; Saijo Nagahiro
[Strategy of therapy for lung cancer]
Nippon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 5():305-8.
2002: Naruse Ichiro; Fukumoto Hisao; Saijo Nagahiro; Nishio Kazuto
Enhanced anti-tumor effect of trastuzumab in combination with cisplatin.
Japanese journal of cancer research : Gann 2002;93(5):574-81.
2002: Fukuoka Kazuya; Arioka Hitoshi; Iwamoto Yasuo; Fukumoto Hisao; Kurokawa Hirokazu; Ishida Tomoyuki; Tomonari Akira; Suzuki Toshihiro; Usuda Jitsuo; Kanzawa Fumihiko; Kimura Hiroshi; Saijo Nagahiro; Nishio Kazuto
Mechanism of vinorelbine-induced radiosensitization of human small cell lung cancer cells.
Cancer chemotherapy and pharmacology 2002;49(5):385-90.
2002: Takahashi Fumiyuki; Akutagawa Shigeru; Fukumoto Hisao; Tsukiyama Shoji; Ohe Yuichiro; Takahashi Kazuhisa; Fukuchi Yoshinosuke; Saijo Nagahiro; Nishio Kazuto
Osteopontin induces angiogenesis of murine neuroblastoma cells in mice.
International journal of cancer. Journal international du cancer 2002;98(5):707-12.
2002: Naruse Ichiro; Ohmori Tohru; Ao Yoko; Fukumoto Hisao; Kuroki Toshio; Mori Masatomo; Saijo Nagahiro; Nishio Kazuto
Antitumor activity of the selective epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) Iressa (ZD1839) in an EGFR-expressing multidrug-resistant cell line in vitro and in vivo.
International journal of cancer. Journal international du cancer 2002;98(2):310-5.
2002: Koh Yasuhiro; Tsunoda Takuya; Iwahashi Makoto; Yamaue Hiroki; Ishimoto Kiwao; Tanimura Hiroshi; Fukumoto Hisao; Nakamura Takashi; Tatsumi Yasuaki; Shimizu Mikiko; Saijo Nagahiro; Nishio Kazuto
Decreased expression of alpha2,8 sialyltransferase and increased expression of beta1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers.
Experimental biology and medicine (Maywood, N.J.) 2002;227(3):196-200.
2002: Kusaba Hitoshi; Tamura Tomohide; Shimoyama Tatsu; Hotta Katsuyuki; Inoue Akira; Nokihara Hiroshi; Ueda Yutaka; Akiyama Yoshiko; Yamamoto Noboru; Sekine Ikuo; Kunitoh Hideo; Ohe Yuichiro; Kodama Tetsuro; Saijo Nagahiro
Phase I/II study of 3-week cycle cisplatin-gemcitabine in advanced non-small cell lung cancer.
Japanese journal of clinical oncology 2002;32(2):43-7.
2002: Kato Yasufumi; Saijo Nagahiro
[Developed new agents for lung cancer]
Nippon Geka Gakkai zasshi 2002;103(2):218-23.
2002: Akaza Hideyuki; Aiba Keisuke; Isonishi Seiji; Ikeda Tadashi; Ohashi Yasuo; Kawai Koji; Saijo Nagahiro; Saeki Toshiaki; Sone Saburo; Tsukagoshi Shigeru; Tsuruo Takashi; Boku Narikazu; Kato Masuhiro; Mikami Osamu; Blackledge George; Stribling Don
[Globalization of anti-cancer therapies]
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29(2):205-14.
2002: Sekine Ikuo; Nishiwaki Yutaka; Ogino Takashi; Yokoyama Akira; Saito Mari; Mori Kiyoshi; Tsukiyama Iwao; Tsuchiya Satoshi; Hayakawa Kazushige; Yoshimura Kimio; Ishizuka Naoki; Saijo Nagahiro
Phase II study of twice-daily high-dose thoracic radiotherapy alternating with cisplatin and vindesine for unresectable stage III non-small-cell lung cancer: Japan Clinical Oncology Group Study 9306.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(3):797-803.
2002: Natsume Tsugitaka; Koh Yasuhiro; Kobayashi Motohiro; Fukumoto Hisao; Takahashi Fumiyuki; Nakamura Takashi; Ohe Yuichiro; Saijo Nagahiro; Nishio Kazuto
Enhanced antitumor activities of TZT-1027 against TNF-alpha or IL-6 secreting Lewis lung carcinoma in vivo.
Cancer chemotherapy and pharmacology 2002;49(1):35-47.
2002: Noda Kazumasa; Nishiwaki Yutaka; Kawahara Masaaki; Negoro Shunichi; Sugiura Takahiko; Yokoyama Akira; Fukuoka Masahiro; Mori Kiyoshi; Watanabe Koshiro; Tamura Tomohide; Yamamoto Seiichiro; Saijo Nagahiro;
Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer.
The New England journal of medicine 2002;346(2):85-91.
2002: Saeki Mayumi; Ozawa Shogo; Saito Yoshiro; Jinno Hideto; Hamaguchi Tetsuya; Nokihara Hiroshi; Shimada Yasuhiro; Kunitoh Hideo; Yamamoto Noboru; Ohe Yuichiro; Yamada Yasuhide; Shirao Kuniaki; Muto Manabu; Mera Kiyomi; Goto Koichi; Ohmatsu Hironobu; Kubota Kaoru; Niho Seiji; Kakinuma Ryutaro; Minami Hironobu; Ohtsu Atsushi; Yoshida Teruhiko; Saijo Nagahiro; Sawada Jun-ichi
Three novel single nucleotide polymorphisms in UGT1A10.
Drug metabolism and pharmacokinetics 2002;17(5):488-90.
2002: Yoshino Keiichi; Takahashi Y; Nakajima Toshifusa; Yoshida Shigeaki; Saijo Nagahiro; Maehara Yoshihiko; Sakata Yu; Yamagishi Hisakazu; Takeshita Kimiya; Ono Hiroyuki; Kitagawa Yuko; Kitano Seigo
Meeting report of the 74th Congress of the Japanese Gastric Cancer Association.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2002;5(4):185-93.
2001: Hotta K; Sekine I; Tamura T; Sawada M; Watanabe H; Kusaba H; Akiyama Y; Inoue A; Shimoyama T; Nokihara H; Ueda Y; Yamamoto N; Kunitoh H; Ohe Y; Kodama T; Saijo N
A phase I/II study of cisplatin and vinorelbine chemotherapy in patients with advanced non-small cell lung cancer.
Japanese journal of clinical oncology 2001;31(12):596-600.
2001: Fukuoka K; Arioka H; Iwamoto Y; Fukumoto H; Kurokawa H; Ishida T; Tomonari A; Suzuki T; Usuda J; Kanzawa F; Saijo N; Nishio K
Mechanism of the radiosensitization induced by vinorelbine in human non-small cell lung cancer cells.
Lung cancer (Amsterdam, Netherlands) 2001;34(3):451-60.
2001: Yoshida M; Feng W; Nishio K; Takahashi M; Heike Y; Saijo N; Wakasugi H; Ikekawa T
Antitumor action of the PKC activator gnidimacrin through cdk2 inhibition.
International journal of cancer. Journal international du cancer 2001;94(3):348-52.
2001: Akiyama Y; Ohe Y; Tamura T; Sawada M; Inoue A; Kusaba H; Yamamoto N; Sekine I; Kunitoh H; Kodama T; Saijo N
A dose escalation study of paclitaxel and carboplatin in untreated Japanese patients with advanced non-small cell lung cancer.
Japanese journal of clinical oncology 2001;31(10):482-7.
2001: Matsumoto K; Saijo N
[Issues in cancer treatments--EBM, individuation, and standardization]
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(10):1323-30.
2001: Kunitoh H; Akiyama Y; Kusaba H; Yamamoto N; Sekine I; Ohe Y; Kubota K; Tamura T; Shinkai T; Kodama T; Goto K; Niho S; Nishiwaki Y; Saijo N
A phase I/II trial of cisplatin, docetaxel and ifosfamide in advanced or recurrent non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2001;33(2-3):259-65.
2001: Usuda J; Okunaka T; Furukawa K; Tsuchida T; Kuroiwa Y; Ohe Y; Saijo N; Nishio K; Konaka C; Kato H
Increased cytotoxic effects of photodynamic therapy in IL-6 gene transfected cells via enhanced apoptosis.
International journal of cancer. Journal international du cancer 2001;93(4):475-80.
2001: Inoue A; Saijo N
Recent advances in the chemotherapy of non-small cell lung cancer.
Japanese journal of clinical oncology 2001;31(7):299-304.
2001: Tatsumi Y; Arioka H; Ikeda S; Fukumoto H; Miyamoto K; Fukuoka K; Ohe Y; Saijo N; Nishio K
Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6.
Japanese journal of cancer research : Gann 2001;92(7):768-77.
2001: Nakamura T; Koizumi F; Kaneko N; Tamura T; Chiwaki F; Koh Y; Akutagawa S; Saijo N; Nishio K
Reversal of cisplatin resistance by the 1,4-benzothiazepine derivative, JTV-519.
Japanese journal of cancer research : Gann 2001;92(6):597-602.
2001: Sekine I; Saijo N
Growth-stimulating pathways in lung cancer: implications for targets of therapy.
Clinical lung cancer 2001;2(4):299-306; discussion 307.
2001: Akaza H; Saijo N; Aiba K; Isonishi S; Ohashi Y; Kawai K; Konishi T; Saeki T; Sone S; Tsukagoshi S; Tsuruo T; Noguchi S; Miki T; Mikami O; Smith M; Hoctin-Boes G; Stribling D
[Platinum compounds in cancer therapy--past, present, and future]
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(5):625-35.
2001: Ueda Y; Saijo N
[Signal transduction inhibitor]
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(5):591-600.
2001: Shimizu M; Tamura T; Yamada Y; Akiyama Y; Saijo N; Nishio K
CPT-11 alters the circadian rhythm of dihydropyrimidine dehydrogenase mRNA in mouse liver.
Japanese journal of cancer research : Gann 2001;92(5):554-61.
2001: Nishio K; Nakamura T; Koh Y; Kanzawa F; Tamura T; Saijo N
Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cells.
Cancer 2001;91(8):1494-9.
2001: Ohe Y; Niho S; Kakinuma R; Kubota K; Matsumoto T; Ohmatsu H; Goto K; Kunitoh H; Saijo N; Nishiwaki Y
Phase I studies of cisplatin and docetaxel administered by three consecutive weekly infusions for advanced non-small cell lung cancer in elderly and non-elderly patients.
Japanese journal of clinical oncology 2001;31(3):100-6.
2001: Ohe Y; Saijo N
Topoisomerase I targeting agents in small-cell lung cancer.
Current oncology reports 2001;3(2):170-8.
2001: Inoue A; Kunitoh H; Sekine I; Sumi M; Tokuuye K; Saijo N
Radiation pneumonitis in lung cancer patients: a retrospective study of risk factors and the long-term prognosis.
International journal of radiation oncology, biology, physics 2001;49(3):649-55.
2001: Tsunoda T; Nakamura T; Ishimoto K; Yamaue H; Tanimura H; Saijo N; Nishio K
Upregulated expression of angiogenesis genes and down regulation of cell cycle genes in human colorectal cancer tissue determined by cDNA macroarray.
Anticancer research 2001;21(1A):137-43.
2001: Kanzawa F; Koizumi F; Koh Y; Nakamura T; Tatsumi Y; Fukumoto H; Saijo N; Yoshioka T; Nishio K
In vitro synergistic interactions between the cisplatin analogue nedaplatin and the DNA topoisomerase I inhibitor irinotecan and the mechanism of this interaction.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(1):202-9.
2001: Natsume T; Nakamura T; Koh Y; Kobayashi M; Saijo N; Nishio K
Gene expression profiling of exposure to TZT-1027, a novel microtubule-interfering agent, in non-small cell lung cancer PC-14 cells and astrocytes.
Investigational new drugs 2001;19(4):293-302.
2001: Fukuoka K; Usuda J; Iwamoto Y; Fukumoto H; Nakamura T; Yoneda T; Narita N; Saijo N; Nishio K
Mechanisms of action of the novel sulfonamide anticancer agent E7070 on cell cycle progression in human non-small cell lung cancer cells.
Investigational new drugs 2001;19(3):219-27.
2000: Kuh H J; Nakagawa S; Usuda J; Yamaoka K; Saijo N; Nishio K
A computational model for quantitative analysis of cell cycle arrest and its contribution to overall growth inhibition by anticancer agents.
Japanese journal of cancer research : Gann 2000;91(12):1303-13.
2000: Fukuoka K; Yamagishi T; Ichihara T; Nakaike S; Iguchi K; Yamada Y; Fukumoto H; Yoneda T; Samata K; Ikeya H; Nanaumi K; Hirayama N; Narita N; Saijo N; Nishio K
Mechanism of action of aragusterol a (YTA0040), a potent anti-tumor marine steroid targeting the G(1) phase of the cell cycle.
International journal of cancer. Journal international du cancer 2000;88(5):810-9.
2000: Fujishiro M; Shinkai T; Fukuda M; Tamura T; Ohe Y; Kunitoh H; Nishiwaki Y; Sekine I; Fukuda H; Saijo N
Phase I study of a weekly infusion of irinotecan hydrochloride (CPT-11) and a 14-day continuous infusion of etoposide in patients with lung cancer: JCOG trial 9408.
Japanese journal of clinical oncology 2000;30(11):487-93.
2000: Murakami H; Ohe Y; Saijo N
[The strategy of combination phase I/II study]
Gan to kagaku ryoho. Cancer & chemotherapy 2000;27(13):2151-4.
2000: Sekine I; Matsuda T; Saisho T; Watanabe H; Yamamoto N; Kunitoh H; Ohe Y; Tamura T; Kodama T; Saijo N
Bacterial meningitis observed in a phase I trial of vinorelbine, cisplatin and thoracic radiotherapy for non-small cell lung cancer: report of a case and discussion on dose-limiting toxicity.
Japanese journal of clinical oncology 2000;30(9):401-5.
2000: Ohe Y; Saijo N
[The role of the Japan Clinical Oncology Group]
Gan to kagaku ryoho. Cancer & chemotherapy 2000;27(8):1127-32.
2000: Yamamoto N; Tamura T; Kamiya Y; Sekine I; Kunitoh H; Saijo N
Correlation between docetaxel clearance and estimated cytochrome P450 activity by urinary metabolite of exogenous cortisol.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(11):2301-8.
2000: Watanabe T; Shimizu C; Katsumata N; Saijo N
[Trastuzumab for treatment of advanced breast cancers]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl():340-4.
2000: Watanabe T; Katsumata N; Saijo N
[Treatment guideline for advanced or recurrent breast cancer]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl():237-45.
2000: Fukuoka K; Nishio K; Fukumoto H; Arioka H; Kurokawa H; Ishida T; Iwamoto Y; Tomonari A; Suzuki T; Usuda J; Narita N; Saijo N
Ectopic p16(ink4) expression enhances CPT-11-induced apoptosis through increased delay in S-phase progression in human non-small-cell-lung-cancer cells.
International journal of cancer. Journal international du cancer 2000;86(2):197-203.
2000: Suzuki T; Sasaki H; Kuh H J; Agui M; Tatsumi Y; Tanabe S; Terada M; Saijo N; Nishio K
Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts.
Gene 2000;242(1-2):167-73.
2000: Watanabe H; Saijo N
[Evidence based chemotherapy for lung cancer]
Gan to kagaku ryoho. Cancer & chemotherapy 2000;27(1):30-43.
2000: Usuda J; Saijo N; Fukuoka K; Fukumoto H; Kuh H J; Nakamura T; Koh Y; Suzuki T; Koizumi F; Tamura T; Kato H; Nishio K
Molecular determinants of UCN-01-induced growth inhibition in human lung cancer cells.
International journal of cancer. Journal international du cancer 2000;85(2):275-80.
2000: Nakamura Y; Sekine I; Furuse K; Saijo N
Retrospective comparison of toxicity and efficacy in phase II trials of 3-h infusions of paclitaxel for patients 70 years of age or older and patients under 70 years of age.
Cancer chemotherapy and pharmacology 2000;46(2):114-8.
2000: Saijo N; Tamura T; Nishio K
Problems in the development of target-based drugs.
Cancer chemotherapy and pharmacology 2000;46 Suppl():S43-5.
1999: Kunitoh H; Sekine I; Kubota K; Tamura T; Shinkai T; Kodama T; Saijo N; Naruke T; Yamaguchi N
Histologic types of lung carcinoma and related family history of anatomic sites and histologic types of cancers.
Cancer 1999;86(7):1182-8.
1999: Fukumoto H; Nishio K; Ohta S; Hanai N; Fukuoka K; Ohe Y; Sugihara K; Kodama T; Saijo N
Effect of a chimeric anti-ganglioside GM2 antibody on ganglioside GM2-expressing human solid tumors in vivo.
International journal of cancer. Journal international du cancer 1999;82(5):759-64.
1999: Nishio K; Nakamura T; Koh Y; Suzuki T; Fukumoto H; Saijo N
Drug resistance in lung cancer.
Current opinion in oncology 1999;11(2):109-15.
1999: Nishio K; Fukuoka K; Fukumoto H; Sunami T; Iwamoto Y; Suzuki T; Usuda J; Saijo N
Mitogen-activated protein kinase antisense oligonucleotide inhibits the growth of human lung cancer cells.
International journal of oncology 1999;14(3):461-9.
1999: Arioka H; Nishio K; Ishida T; Fukumoto H; Fukuoka K; Nomoto T; Kurokawa H; Yokote H; Abe S; Saijo N
Enhancement of cisplatin sensitivity in high mobility group 2 cDNA-transfected human lung cancer cells.
Japanese journal of cancer research : Gann 1999;90(1):108-15.
1999: Kurokawa H; Nishio K; Fukumoto H; Tomonari A; Suzuki T; Saijo N
Alteration of caspase-3 (CPP32/Yama/apopain) in wild-type MCF-7, breast cancer cells.
Oncology reports 1999;6(1):33-7.
1999: Fukumoto H; Tamura T; Kamiya Y; Usuda J; Suzuki T; Kanzawa F; Kuh H J; Ohe Y; Saijo N; Nishio K
Activation-induced apoptosis of peripheral lymphocytes treated with 7-hydroxystaurosporine, UCN-01.
Investigational new drugs 1999;17(4):335-41.
1999: Sunami T; Nishio K; Kanzawa F; Fukuoka K; Kudoh S; Yoshikawa J; Saijo N
Combination effects of TAS-103, a novel dual topoisomerase I and II inhibitor, with other anticancer agents on human small cell lung cancer cells.
Cancer chemotherapy and pharmacology 1999;43(5):394-401.
1999: Kanzawa F; Nishio K; Fukuoka K; Sunami T; Saijo N
In vitro interactions of a new derivative of spicamycin, KRN5500, and other anticancer drugs using a three-dimensional model.
Cancer chemotherapy and pharmacology 1999;43(5):353-63.
1998: Yokote H; Nishio K; Arioka H; Kurokawa H; Fukuoka K; Fukumoto H; Ishida T; Terada T; Itakura T; Saijo N
The C-terminal domain of p53 catalyzes DNA-renaturation and strand exchange toward annealing between intact ssDNAs and toward eliminating damaged ssDNA from duplex formation through preferential recognition of damaged DNA by a duocarmycin.
Mutation research 1998;409(3):147-62.
1998: Nomoto T; Nishio K; Ishida T; Mori M; Saijo N
Characterization of a human small-cell lung cancer cell line resistant to a new water-soluble camptothecin derivative, DX-8951f.
Japanese journal of cancer research : Gann 1998;89(11):1179-86.
1998: Naruse I; Heike Y; Hama S; Mori M; Saijo N
High concentrations of recombinant adenovirus expressing p16 gene induces apoptosis in lung cancer cell lines.
Anticancer research 1998;18(6A):4275-82.
1998: Minami H; Sasaki Y; Saijo N; Ohtsu T; Fujii H; Igarashi T; Itoh K
Indirect-response model for the time course of leukopenia with anticancer drugs.
Clinical pharmacology and therapeutics 1998;64(5):511-21.
1998: Sekine I; Kubota K; Nishiwaki Y; Sasaki Y; Tamura T; Saijo N
Response rate as an endpoint for evaluating new cytotoxic agents in phase II trials of non-small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9(10):1079-84.
1998: Iwamoto Y; Nishio K; Fukumoto H; Yoshimatsu K; Yamakido M; Saijo N
Preferential binding of E7010 to murine beta 3-tubulin and decreased beta 3-tubulin in E7010-resistant cell lines.
Japanese journal of cancer research : Gann 1998;89(9):954-62.
1998: Sekine I; Fukuda H; Kunitoh H; Saijo N
Cancer chemotherapy in the elderly.
Japanese journal of clinical oncology 1998;28(8):463-73.
1998: Yoshida M; Yokokura H; Hidaka H; Ikekawa T; Saijo N
Mechanism of antitumor action of PKC activator, gnidimacrin.
International journal of cancer. Journal international du cancer 1998;77(2):243-50.
1998: Hama S; Heike Y; Naruse I; Takahashi M; Yoshioka H; Arita K; Kurisu K; Goldman C K; Curiel D T; Saijo N
Adenovirus-mediated p16 gene transfer prevents drug-induced cell death through G1 arrest in human glioma cells.
International journal of cancer. Journal international du cancer 1998;77(1):47-54.
1998: Fukuoka K; Narita N; Saijo N
Increased expression of sialyl Lewis(x) antigen is associated with distant metastasis in lung cancer patients: immunohistochemical study on bronchofiberscopic biopsy specimens.
Lung cancer (Amsterdam, Netherlands) 1998;20(2):109-16.
1998: Kunitoh H; Saijo N; Furuse K; Noda K; Ogawa M
Neuromuscular toxicities of paclitaxel 210 mg m(-2) by 3-hour infusion.
British journal of cancer 1998;77(10):1686-8.
1998: Kasai T; Ohe Y; Nishio K; Kunitoh H; Tamura T; Sekine I; Kubota K; Yamamoto N; Nakamura Y; Shinkai T; Kodama T; Saijo N
Factors that influence the eligibility of cases for inclusion in clinical trials. The Lung Cancer Chemotherapy Study Group of the Japan Clinical Oncology Group.
Japanese journal of clinical oncology 1998;28(3):214-21.
1998: Saijo N
[Academism and commercialism with development of new anticancer agents]
Gan to kagaku ryoho. Cancer & chemotherapy 1998;25(2):282-6.
1998: Saijo N
New chemotherapeutic agents for the treatment of non-small cell lung cancer: the Japanese experience.
Chest 1998;113(1 Suppl):17S-23S.
1997: Heike Y; Takahashi M; Ohira T; Naruse I; Hama S; Ohe Y; Kasai T; Fukumoto H; Olsen K J; Podack E E; Saijo N
Genetic immunotherapy by intrapleural, intraperitoneal and subcutaneous injection of IL-2 gene-modified Lewis lung carcinoma cells.
International journal of cancer. Journal international du cancer 1997;73(6):844-9.
1997: Ogasawara H; Nishio K; Ishida T; Arioka H; Fukuoka K; Saijo N
In vitro enhancement of antitumor activity of a water-soluble duocarmycin derivative, KW-2189, by caffeine-mediated DNA-repair inhibition in human lung cancer cells.
Japanese journal of cancer research : Gann 1997;88(11):1033-7.
1997: Fukuoka K; Adachi J; Nishio K; Arioka H; Kurokawa H; Fukumoto H; Ishida T; Nomoto T; Yokote H; Tomonari A; Narita N; Yokota J; Saijo N
p16INK4 expression is associated with the increased sensitivity of human non-small cell lung cancer cells to DNA topoisomerase I inhibitors.
Japanese journal of cancer research : Gann 1997;88(10):1009-16.
1997: Naruse I; Saijo N
[International consensus for lung cancer treatment]
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24 Suppl 3():451-9.
1997: Suzuki T; Nishio K; Sasaki H; Kurokawa H; Saito-Ohara F; Ikeuchi T; Tanabe S; Terada M; Saijo N
cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line.
Biochemical and biophysical research communications 1997;238(3):790-4.
1997: Ishida T; Nishio K; Kurokawa H; Arioka H; Fukumoto H; Fukuoka K; Nomoto T; Yokote H; Hasegawa S; Saijo N
Circumvention of glutathione-mediated mitomycin C resistance by a novel mitomycin C analogue, KW-2149.
International journal of cancer. Journal international du cancer 1997;72(5):865-70.
1997: Fukuoka K; Saijo N
[Antimitotic agents]
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(11):1519-25.
1997: Yamamoto N; Tamura T; Nishiwaki Y; Kurita Y; Kawakami Y; Abe S; Nakabayashi T; Suzuki S; Matsuda T; Hayashi I; Takahashi T; Saijo N
Limited sampling model for the area under the concentration versus time curve of irinotecan and its application to a multicentric phase II trial.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(7):1087-92.
1997: Tomonari A; Nishio K; Kurokawa H; Fukumoto H; Fukuoka K; Iwamoto Y; Usuda J; Suzuki T; Itakura M; Saijo N
Proximal 5'-flanking sequence of the human gamma-glutamylcysteine synthetase heavy subunit gene is involved in cisplatin-induced transcriptional up-regulation in a lung cancer cell line SBC-3.
Biochemical and biophysical research communications 1997;236(3):616-21.
1997: Fukumoto H; Nishio M; Nishio K; Heike Y; Arioka H; Kurokawa H; Ishida T; Fukuoka K; Nomoto T; Ohe Y; Saijo N
Interferon-gamma-inducing factor gene transfection into Lewis lung carcinoma cells reduces tumorigenicity in vivo.
Japanese journal of cancer research : Gann 1997;88(5):501-5.
1997: Hama S; Sadatomo T; Yoshioka H; Kurisu K; Tahara E; Naruse I; Heike Y; Saijo N
Transformation of human glioma cell lines with the p16 gene inhibits cell proliferation.
Anticancer research 1997;17(3C):1933-8.
1997: Hama S; Kurisu K; Saijo N
[Cyclosporine as drug resistance modifiers; mechanism and clinical investigation]
Nippon rinsho. Japanese journal of clinical medicine 1997;55(5):1103-10.
1997: Kanzawa F; Nishio K; Fukuoka K; Fukuda M; Kunimoto T; Saijo N
Evaluation of synergism by a novel three-dimensional model for the combined action of cisplatin and etoposide on the growth of a human small-cell lung-cancer cell line, SBC-3.
International journal of cancer. Journal international du cancer 1997;71(3):311-9.
1997: Kanzawa F; Saijo N
In vitro interaction between gemcitabine and other anticancer drugs using a novel three-dimensional model.
Seminars in oncology 1997;24(2 Suppl 7):S7-8-S7-16.
1997: Tomonari A; Nishio K; Kurokawa H; Arioka H; Ishida T; Fukumoto H; Fukuoka K; Nomoto T; Iwamoto Y; Heike Y; Itakura M; Saijo N
Identification of cis-acting DNA elements of the human gamma-glutamylcysteine synthetase heavy subunit gene.
Biochemical and biophysical research communications 1997;232(2):522-7.
1997: Kurokawa H; Nishio K; Ishida T; Arioka H; Fukuoka K; Nomoto T; Fukumoto H; Yokote H; Saijo N
Effect of glutathione depletion on cisplatin resistance in cancer cells transfected with the gamma-glutamylcysteine synthetase gene.
Japanese journal of cancer research : Gann 1997;88(2):108-10.
1997: Nishio K; Kurokawa H; Ishida T; Fukuoka K; Saijo N
[gamma-Glutamylcysteine synthetase and chemosensitivity]
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(4):418-23.
1997: Okusaka T; Eguchi K; Kasai T; Kurata T; Yamamoto N; Ohe Y; Tamura T; Shinkai T; Saijo N
Serum levels of pro-gastrin-releasing peptide for follow-up of patients with small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(1):123-7.
1997: Yamamoto N; Tamura T; Ohe Y; Oshita F; Kasai T; Kurata T; Shinkai T; Eguchi K; Saijo N
Chronopharmacology of etoposide given by low dose prolonged infusion in lung cancer patients.
Anticancer research 1997;17(1B):669-72.
1997: Nishio K; Arioka H; Saijo N
[Apoptosis and chemosensitivity]
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(2):216-21.
1997: Oshita F; Noda K; Nishiwaki Y; Fujita A; Kurita Y; Nakabayashi T; Tobise K; Abe S; Suzuki S; Hayashi I; Kawakami Y; Matsuda T; Tsuchiya S; Takahashi S; Tamura T; Saijo N
Phase II study of irinotecan and etoposide in patients with metastatic non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(1):304-9.
1997: Kanzawa F; Nishio K; Ishida T; Fukuda M; Kurokawa H; Fukumoto H; Nomoto Y; Fukuoka K; Bojanowski K; Saijo N
Anti-tumour activities of a new benzo[c]phenanthridine agent, 2,3-(methylenedioxy)-5-methyl-7-hydroxy-8-methoxybenzo[c]phena nthridini um hydrogensulphate dihydrate (NK109), against several drug-resistant human tumour cell lines.
British journal of cancer 1997;76(5):571-81.
1997: Saijo N
Chemotherapy: the more the better? Overview.
Cancer chemotherapy and pharmacology 1997;40 Suppl():S100-6.
1997: Arioka H; Nishio K; Heike Y; Abe S; Saijo N
In vitro and in vivo modulation by rhizoxin of non-P-glycoprotein-mediated vindesine resistance.
Journal of cancer research and clinical oncology 1997;123(4):195-200.
1996: Saijo N
Clinical trials of irinotecan hydrochloride (CPT, campto injection, topotecin injection) in Japan.
Annals of the New York Academy of Sciences 1996;803():292-305.
1996: Nishio K; Ishida T; Arioka H; Kurokawa H; Fukuoka K; Nomoto T; Fukumoto H; Yokote H; Saijo N
Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines.
Anticancer research 1996;16(6B):3387-95.
1996: Fukuda M; Inomata M; Nishio K; Fukuoka K; Kanzawa F; Arioka H; Ishida T; Fukumoto H; Kurokawa H; Oka M; Saijo N
A topoisomerase II inhibitor, NK109, induces DNA single- and double-strand breaks and apoptosis.
Japanese journal of cancer research : Gann 1996;87(10):1086-91.
1996: Ohira T; Nishio K; Kanzawa F; Ishida T; Ohe Y; Arioka H; Funayama Y; Ogasawara H; Kato H; Saijo N
Hypersensitivity of NIH3T3 cells transformed by H-ras gene to DNA-topoisomerase-I inhibitors.
International journal of cancer. Journal international du cancer 1996;67(5):702-8.
1996: Fukumoto H; Nishio K; Ohta S; Hanai N; Saijo N
Reversal of adriamycin resistance with chimeric anti-ganglioside GM2 antibody.
International journal of cancer. Journal international du cancer 1996;67(5):676-80.
1996: Fukumoto H; Saijo N
[Selection of drugs for chemotherapy based on drug resistance marker]
Nippon rinsho. Japanese journal of clinical medicine 1996;54(6):1680-4.
1996: Yoshida M; Feng W; Saijo N; Ikekawa T
Antitumor activity of daphnane-type diterpene gnidimacrin isolated from Stellera chamaejasme L.
International journal of cancer. Journal international du cancer 1996;66(2):268-73.
1996: Katsumata N; Eguchi K; Fukuda M; Yamamoto N; Ohe Y; Oshita F; Tamura T; Shinkai T; Saijo N
Serum levels of cytokines in patients with untreated primary lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(3):553-9.
1996: Fukuda M; Nishio K; Kanzawa F; Ogasawara H; Ishida T; Arioka H; Bojanowski K; Oka M; Saijo N
Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38, in human small cell lung cancer cells.
Cancer research 1996;56(4):789-93.
1996: Funayama Y; Nishio K; Wakabayashi K; Nagao M; Shimoi K; Ohira T; Hasegawa S; Saijo N
Effects of beta- and gamma-carboline derivatives of DNA topoisomerase activities.
Mutation research 1996;349(2):183-91.
1996: Ohira T; Nishio K; Ohe Y; Arioka H; Nishio M; Funayama Y; Ogasawara H; Fukuda M; Yazawa K; Kato H; Saijo N
Improvement by eicosanoids in cancer cachexia induced by LLC-IL6 transplantation.
Journal of cancer research and clinical oncology 1996;122(12):711-5.
1996: Saijo N; Nishio K; Ohta S; Arioka H; Funayama Y; Fukuoka K; Kurokawa H; Nomoto T; Ishida T; Yamamoto N; Tamura T; Shinkai T; Eguchi K; Ohe Y; Kunito H; Ohtsu T; Sasaki Y
Progress in preclinical and clinical studies for the development of new anticancer drugs in Japan, with emphasis on taxanes.
Cancer chemotherapy and pharmacology 1996;38 Suppl():S11-5.
1995: Kasai T; Saijo N
[Can improvement in therapy decrease the rate of death due to lung cancer?]
Nihon Kyobu Shikkan Gakkai zasshi 1995;33 Suppl():17-23.
1995: Oshita F; Kurata T; Kasai T; Fakuda M; Yamamoto N; Ohe Y; Tamura T; Eguchi K; Shinkai T; Saijo N
Prospective evaluation of the feasibility of cisplatin-based chemotherapy for elderly lung cancer patients with normal organ functions.
Japanese journal of cancer research : Gann 1995;86(12):1198-202.
1995: Saijo N; Nishio K; Takeda Y; Arioka H; Ishida T; Nomoto T; Fukuoka K; Kurokawa H; Fukumoto H
Phorbol ester and okadaic acid-resistant cells: the crossroads of signal transduction and drug resistance.
The American journal of medicine 1995;99(6A):35S-39S.
1995: Nishio K; Arioka H; Ishida T; Fukumoto H; Kurokawa H; Sata M; Ohata M; Saijo N
Enhanced interaction between tubulin and microtubule-associated protein 2 via inhibition of MAP kinase and CDC2 kinase by paclitaxel.
International journal of cancer. Journal international du cancer 1995;63(5):688-93.
1995: Kurokawa H; Ishida T; Nishio K; Arioka H; Sata M; Fukumoto H; Miura M; Saijo N
Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance.
Biochemical and biophysical research communications 1995;216(1):258-64.
1995: Nomoto T; Nishio K; Saijo N
[Cell cycle regulation by anticancer agent]
Gan to kagaku ryoho. Cancer & chemotherapy 1995;22(12):1719-23.
1995: Kanzawa F; Nishio K; Kubota N; Saijo N
Antitumor activities of a new indolocarbazole substance, NB-506, and establishment of NB-506-resistant cell lines, SBC-3/NB.
Cancer research 1995;55(13):2806-13.
1995: Oshita F; Yamamoto N; Fukuda M; Ohe Y; Tamura T; Eguchi K; Shinkai T; Saijo N
Correlation of therapeutic outcome in non-small cell lung cancer and DNA damage assayed by polymerase chain reaction in leukocytes damaged in vitro.
Cancer research 1995;55(11):2334-7.
1995: Fukuda M; Ohe Y; Kanzawa F; Oka M; Hara K; Saijo N
Evaluation of novel platinum complexes, inhibitors of topoisomerase I and II in non-small cell lung cancer (NSCLC) sublines resistant to cisplatin.
Anticancer research 1995;15(2):393-8.
1995: Saijo N
[Strategies for the overcoming of drug resistance]
Gan to kagaku ryoho. Cancer & chemotherapy 1995;22(3):371-81.
1995: Ogasawara H; Nishio K; Kanzawa F; Lee Y S; Funayama Y; Ohira T; Kuraishi Y; Isogai Y; Saijo N
Intracellular carboxyl esterase activity is a determinant of cellular sensitivity to the antineoplastic agent KW-2189 in cell lines resistant to cisplatin and CPT-11.
Japanese journal of cancer research : Gann 1995;86(1):124-9.
1995: Heike Y; Takahashi M; Ohira T; Arioka H; Funayama Y; Nishio K; Ogasawara H; Saijo N
In vivo screening models of cisplatin-resistant human lung cancer cell lines using SCID mice.
Cancer chemotherapy and pharmacology 1995;35(3):200-4.
1995: Inomata M; Saijo N; Kawashima K; Kaneko A; Fujiwara Y; Kunikane H; Tanaka Y
Induction of apoptosis in cultured retinoblastoma cells by the protein phosphatase inhibitor, okadaic acid.
Journal of cancer research and clinical oncology 1995;121(12):729-38.
1994: Nishio K; Miura K; Ohira T; Heike Y; Saijo N
Genistein, a tyrosine kinase inhibitor, decreased the affinity of p56lck to beta-chain of interleukin-2 receptor in human natural killer (NK)-rich cells and decreased NK-mediated cytotoxicity.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;207(2):227-33.
1994: Kondo H; Kanzawa F; Nishio K; Saito S; Saijo N
In vitro and in vivo effects of cisplatin and etoposide in combination on small cell lung cancer cell lines.
Japanese journal of cancer research : Gann 1994;85(10):1050-6.
1994: Koga H; Eguchi K; Shinkai T; Tamura T; Ohe Y; Oshita F; Saijo N; Kondo H; Oki K; Okura H
Preliminary evaluation of the new tumor marker, CYFRA 21-1, in lung cancer patients.
Japanese journal of clinical oncology 1994;24(5):263-8.
1994: Bojanowski K; Nishio K; Fukuda M; Larsen A K; Saijo N
Effect of suramin on p34cdc2 kinase in vitro and in extracts from human H69 cells: evidence for a double mechanism of action.
Biochemical and biophysical research communications 1994;203(3):1574-80.
1994: Takeda Y; Nishio K; Kubota N; Miura K; Morikage T; Ohmori T; Kudoh S; Niitani H; Saijo N
Establishment of a human small-cell lung-cancer subline resistant to okadaic acid.
International journal of cancer. Journal international du cancer 1994;58(6):882-90.
1994: Ogasawara H; Nishio K; Takeda Y; Ohmori T; Kubota N; Funayama Y; Ohira T; Kuraishi Y; Isogai Y; Saijo N
A novel antitumor antibiotic, KW-2189 is activated by carboxyl esterase and induces DNA strand breaks in human small cell lung cancer cells.
Japanese journal of cancer research : Gann 1994;85(4):418-25.
1994: Takeda Y; Nishio K; Niitani H; Saijo N
Reversal of multidrug resistance by tyrosine-kinase inhibitors in a non-P-glycoprotein-mediated multidrug-resistant cell line.
International journal of cancer. Journal international du cancer 1994;57(2):229-39.
1994: Ohta S; Nishio K; Kubota N; Ohmori T; Funayama Y; Ohira T; Nakajima H; Adachi M; Saijo N
Characterization of a taxol-resistant human small-cell lung cancer cell line.
Japanese journal of cancer research : Gann 1994;85(3):290-7.
1994: Okamoto-Kubo S; Nishio K; Heike Y; Yoshida M; Ohmori T; Saijo N
Apoptosis induced by etoposide in small-cell lung cancer cell lines.
Cancer chemotherapy and pharmacology 1994;33(5):385-90.
1994: Inomata M; Kaneko A; Saijo N; Tokura S
Culture of retinoblastoma cells from clinical specimens: growth-promoting effect of 2-mercaptoethanol.
Journal of cancer research and clinical oncology 1994;120(3):149-55.
1994: Saijo N; Nishio K; Kubota N; Kanzawa F; Shinkai T; Karato A; Sasaki Y; Eguchi K; Tamura T; Ohe Y
7-Ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy camptothecin: mechanism of resistance and clinical trials.
Cancer chemotherapy and pharmacology 1994;34 Suppl():S112-7.
1994: Kubota N; Nishio K; Takeda Y; Ohmori T; Funayama Y; Ogasawara H; Ohira T; Kunikane H; Terashima Y; Saijo N
Characterization of an etoposide-resistant human ovarian cancer cell line.
Cancer chemotherapy and pharmacology 1994;34(3):183-90.
1993: Shinkai T; Saijo N
[Phase II clinical trials in patients with lung cancer]
Nihon Kyobu Shikkan Gakkai zasshi 1993;31 Suppl():232-44.
1993: Funayama Y; Nishio K; Takeda Y; Kubota N; Ohira T; Ohmori T; Ohta S; Ogasawara H; Hasegawa S; Saijo N
Suramin inhibits the phosphorylation and catalytic activity of DNA topoisomerase II in human lung cancer cells.
Anticancer research 1993;13(6A):1981-8.
1993: Morikage T; Ohmori T; Nishio K; Fujiwara Y; Takeda Y; Saijo N
Modulation of cisplatin sensitivity and accumulation by amphotericin B in cisplatin-resistant human lung cancer cell lines.
Cancer research 1993;53(14):3302-7.
1993: Ohta S; Krishan A; Nishio K; Ohmori T; Kunikane H; Inomata M; Takahashi T; Saijo N
Effect of taxol on vinblastine sulfate-induced crystallization of tubulin.
Anticancer research 1993;13(4):873-7.
1993: Nishio K; Morikage T; Ohmori T; Kubota N; Takeda Y; Ohta S; Yazawa K; Saijo N
Novel water-soluble derivatives of docosahexaenoic acid increase diacylglycerol production mediated by phosphatidylcholine-specific phospholipase C.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1993;203(2):200-8.
1993: Kojima A; Shinkai T; Saijo N
Cytogenetic effects of CPT-11 and its active metabolite, SN-38 on human lymphocytes.
Japanese journal of clinical oncology 1993;23(2):116-22.
1993: Ohe Y; Podack E R; Olsen K J; Miyahara Y; Ohira T; Miura K; Nishio K; Saijo N
Combination effect of vaccination with IL2 and IL4 cDNA transfected cells on the induction of a therapeutic immune response against Lewis lung carcinoma cells.
International journal of cancer. Journal international du cancer 1993;53(3):432-7.
1993: Ohmori T; Morikage T; Sugimoto Y; Fujiwara Y; Kasahara K; Nishio K; Ohta S; Sasaki Y; Takahashi T; Saijo N
The mechanism of the difference in cellular uptake of platinum derivatives in non-small cell lung cancer cell line (PC-14) and its cisplatin-resistant subline (PC-14/CDDP).
Japanese journal of cancer research : Gann 1993;84(1):83-92.
1992: Miya T; Sasaki Y; Karato A; Saijo N
Pharmacokinetic study of mitomycin C with emphasis on the influence of aging.
Japanese journal of cancer research : Gann 1992;83(12):1382-5.
1992: Ohira T; Ohe Y; Saijo N
[Induction of tumor immunity by cytokine cDNA transfected Lewis lung carcinoma]
Nihon Kyobu Shikkan Gakkai zasshi 1992;30 Suppl():48-51.
1992: Okamoto H; Saijo N; Shinkai T; Eguchi K; Sasaki Y; Tamura T; Ohe Y; Kojima A; Kunikane H; Karato A
Chemotherapy-induced anemia in patients with primary lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1992;3(10):819-24.
1992: Yoshida M; Tanaka Y; Eguchi T; Ikekawa N; Saijo N
Effect of hexafluoro-1,25-dihydroxyvitamin D3 and sodium butyrate combination on differentiation and proliferation of HL-60 leukemia cells.
Anticancer research 1992;12(6B):1947-52.
1992: Kubota N; Kanzawa F; Nishio K; Takeda Y; Ohmori T; Fujiwara Y; Terashima Y; Saijo N
Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line.
Biochemical and biophysical research communications 1992;188(2):571-7.
1992: Nishio K; Morikage T; Kubota N; Ohmori T; Takeda Y; Fujiwara Y; Miki K; Abe K; Saijo N
Alteration of type II regulatory subunit of cAMP-dependent protein kinase in human cisplatin-resistant cells as a basis of collateral sensitivity to 8-chloro-cAMP.
Japanese journal of cancer research : Gann 1992;83(7):754-60.
1992: Sugimoto Y; Ohe Y; Nishio K; Ohmori T; Morikage T; Fujiwara Y; Saijo N
Mechanisms of collateral sensitivity to fluorouracil of a cis-diamminedichloroplatinum(II)-resistant human non-small lung cancer cell line.
British journal of cancer 1992;65(6):857-64.
1992: Nishio K; Sugimoto Y; Fujiwara Y; Ohmori T; Morikage T; Takeda Y; Ohata M; Saijo N
Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by cis-diamminedichloroplatinum(II).
The Journal of clinical investigation 1992;89(5):1622-8.
1992: Kondo H; Shigekiyo T; Kojima A; Saito S; Saijo N
Acquired factor VIII inhibitor in a patient with adenocarcinoma of the lung.
Japanese journal of clinical oncology 1992;22(1):49-53.
1992: Nishio K; Sugimoto Y; Kasahara K; Fujiwara Y; Nishiwaki S; Fujiki H; Ohata M; Saijo N
Increased phosphorylation of nuclear phosphoproteins in human lung-cancer cells resistant to cis-diamminedichloroplatinum (II).
International journal of cancer. Journal international du cancer 1992;50(3):438-42.
1992: Kasahara K; Fujiwara Y; Sugimoto Y; Nishio K; Tamura T; Matsuda T; Saijo N
Determinants of response to the DNA topoisomerase II inhibitors doxorubicin and etoposide in human lung cancer cell lines.
Journal of the National Cancer Institute 1992;84(2):113-8.
1992: Minato K; Manabe T; Okuyama N; Sasaki Y; Nakagawa K; Saijo N
Differences in cellular proteins between high and low metastatic potential sublines from the methylcholanthrene-induced rat fibrosarcoma cell line.
Oncology 1992;49(2):143-6.
1992: Oshita F; Fujiwara Y; Saijo N
Radiation sensitivities in various anticancer-drug-resistant human lung cancer cell lines and mechanism of radiation cross-resistance in a cisplatin-resistant cell line.
Journal of cancer research and clinical oncology 1992;119(1):28-34.
1992: Sugimoto Y; Ohe Y; Nishio K; Ohmori T; Fujiwara Y; Saijo N
In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines.
Cancer chemotherapy and pharmacology 1992;30(6):417-22.
1992: Saijo N
Combined modality therapy for small cell lung cancer.
Oncology 1992;49 Suppl 1():2-9; discussion 10.
1992: Kubo S; Matsutani M; Nakagawa K; Ogura T; Esumi H; Saijo N
Participation of poly(ADP-ribose) polymerase in the drug sensitivity in human lung cancer cell lines.
Journal of cancer research and clinical oncology 1992;118(4):244-8.
1991: Oshita F; Tamura T; Okamoto H; Miya T; Kojima A; Ohe Y; Sasaki Y; Eguchi K; Shinkai T; Saijo N
The frequency and management of infectious episodes and sepsis in small cell lung cancer patients receiving intensive chemotherapy with granulocyte-colony stimulating factor.
Japanese journal of clinical oncology 1991;21(5):353-9.
1991: Morikage T; Bungo M; Inomata M; Yoshida M; Ohmori T; Fujiwara Y; Nishio K; Saijo N
Reversal of cisplatin resistance with amphotericin B in a non-small cell lung cancer cell line.
Japanese journal of cancer research : Gann 1991;82(6):747-51.
1991: Kasahara K; Fujiwara Y; Nishio K; Ohmori T; Sugimoto Y; Komiya K; Matsuda T; Saijo N
Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin.
Cancer research 1991;51(12):3237-42.
1991: Sasaki Y; Amano T; Morita M; Shinkai T; Eguchi K; Tamura T; Ohe Y; Kojima A; Saijo N
Phase I study and pharmacological analysis of cis-diammine(glycolato)platinum (254-S; NSC 375101D) administered by 5-day continuous intravenous infusion.
Cancer research 1991;51(5):1472-7.
1991: Niimi S; Nakagawa K; Yokota J; Tsunokawa Y; Nishio K; Terashima Y; Shibuya M; Terada M; Saijo N
Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and/or c-H-ras genes.
British journal of cancer 1991;63(2):237-41.
1991: Oshita F; Shinkai T; Miya T; Kojima A; Ohe Y; Tamura T; Sasaki Y; Eguchi K; Saijo N
[The relation between myelotoxicity and performance status or aging in chemotherapy of non-small cell lung cancer]
Nihon Kyobu Shikkan Gakkai zasshi 1991;29(2):231-8.
1991: Yamada K; Saijo N; Kojima A; Ohe Y; Tamura T; Sasaki Y; Eguchi K; Shinkai T; Goya T; Kondou H
A retrospective analysis of patients receiving surgery after chemotherapy for small cell lung cancer.
Japanese journal of clinical oncology 1991;21(1):39-45.
1991: Soejima Y; Shen W M; Minato K; Nishio K; Sugimoto Y; Fujiwara Y; Tamura T; Hara K; Saijo N
The development of a treatment model for lymph node metastasis in nude mice transplanted with rat fibrosarcoma clone A.
Invasion & metastasis 1991;11(3):174-80.
1991: Kojima A; Ikeuchi T; Inomata M; Shinkai T; Ishihara K; Noguchi M; Saijo N
Y/6 chromosome translocation in a male with triple primary cancers involving the breast.
Journal of cancer research and clinical oncology 1991;117(5):479-83.
1991: Sasaki Y; Shinkai T; Eguchi K; Tamura T; Ohe Y; Ohmori T; Saijo N
Prediction of the antitumor activity of new platinum analogs based on their ex vivo pharmacodynamics as determined by bioassay.
Cancer chemotherapy and pharmacology 1991;27(4):263-70.
1991: Shinkai T; Eguchi K; Sasaki Y; Tamura T; Ohe Y; Kojima A; Oshita F; Saijo N
A randomised clinical trial of vindesine plus cisplatin versus mitomycin plus vindesine and cisplatin in advanced non-small cell lung cancer.
European journal of cancer (Oxford, England : 1990) 1991;27(5):571-5.
1990: Fujiwara Y; Kasahara K; Sugimoto Y; Nishio K; Ohmori T; Saijo N
Detection of proteins that recognize platinum-modified DNA using gel mobility shift assay.
Japanese journal of cancer research : Gann 1990;81(12):1210-3.
1990: Nishio K; Sugimoto Y; Nakagawa K; Niimi S; Fujiwara Y; Bungo M; Kasahara K; Fujiki H; Saijo N
Cross-resistance to tumour promoters in human cancer cell lines resistant to adriamycin or cisplatin.
British journal of cancer 1990;62(3):415-9.
1990: Fukuda M; Sasaki Y; Morita M; Tsuchiya R; Matsuno Y; Noguchi M; Saijo N
Large cell carcinoma of the lung secreting human chorionic gonadotropin which responded to combination chemotherapy: case report.
Japanese journal of clinical oncology 1990;20(3):299-305.
1990: Kanzawa F; Sugimoto Y; Minato K; Kasahara K; Bungo M; Nakagawa K; Fujiwara Y; Liu L F; Saijo N
Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: characterization and mechanism of resistance.
Cancer research 1990;50(18):5919-24.
1990: Fukuda M; Sasaki Y; Sakamoto M; Noguchi M; Saijo N
Primary lung cancer in an 18-year-old boy: case report.
Japanese journal of clinical oncology 1990;20(2):177-81.
1990: Bungo M; Fujiwara Y; Kasahara K; Nakagawa K; Ohe Y; Sasaki Y; Irino S; Saijo N
Decreased accumulation as a mechanism of resistance to cis-diamminedichloroplatinum(II) in human non-small cell lung cancer cell lines: relation to DNA damage and repair.
Cancer research 1990;50(9):2549-53.
1990: Fujiwara Y; Sugimoto Y; Kasahara K; Bungo M; Yamakido M; Tew K D; Saijo N
Determinants of drug response in a cisplatin-resistant human lung cancer cell line.
Japanese journal of cancer research : Gann 1990;81(5):527-35.
1990: Nakagawa K; Saijo N; Tsuchida S; Sakai M; Tsunokawa Y; Yokota J; Muramatsu M; Sato K; Terada M; Tew K D
Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.
The Journal of biological chemistry 1990;265(8):4296-301.
1990: Bungo M; Nakagawa K; Saijo N
[A mechanism of cisplatin resistance in a cisplatin resistant lung cancer cell line]
Gan to kagaku ryoho. Cancer & chemotherapy 1990;17(3 Pt 2):515-6.
1990: Fukuda M; Shinkai T; Eguchi K; Sasaki Y; Tamura T; Ohe Y; Kojima A; Oshita F; Hara K; Saijo N
Phase II study of (glycolate-O,O') diammineplatinum(II), a novel platinum complex, in the treatment of non-small-cell lung cancer.
Cancer chemotherapy and pharmacology 1990;26(6):393-6.
1990: Minato K; Kanzawa F; Nishio K; Nakagawa K; Fujiwara Y; Saijo N
Characterization of an etoposide-resistant human small-cell lung cancer cell line.
Cancer chemotherapy and pharmacology 1990;26(5):313-7.
1990: Sakurai M; Iigo M; Sasaki Y; Nakagawa K; Fujiwara Y; Tamura T; Ohe Y; Bungo M; Saijo N
Lack of correlation between interferon levels induced by polyribonucleotides and their antimetastatic effect.
Oncology 1990;47(3):251-6.
1989: Shinkai T; Saijo N; Eguchi K; Sasaki Y; Tamura T; Fujiwara Y; Kojima A; Nakagawa K; Minato K; Nakajima T
Serial measurement of sister chromatid exchanges in the peripheral lymphocytes of patients with lung cancer receiving chemotherapy in relation to bone marrow toxicity.
Japanese journal of cancer research : Gann 1989;80(8):783-6.
1989: Ohe Y; Nakagawa K; Fujiwara Y; Sasaki Y; Minato K; Bungo M; Niimi S; Horichi N; Fukuda M; Saijo N
In vitro evaluation of the new anticancer agents KT6149, MX-2, SM5887, menogaril, and liblomycin using cisplatin- or adriamycin-resistant human cancer cell lines.
Cancer research 1989;49(15):4098-102.
1989: Shinkai T; Saijo N; Eguchi K; Sasaki Y; Tamura T; Fujiwara Y; Mae M; Fukuda M; Ohe Y; Sasaki S
Control of cisplatin-induced delayed emesis with metoclopramide and dexamethasone: a randomized controlled trial.
Japanese journal of clinical oncology 1989;19(1):40-4.
1989: Ohsaki Y; Ohe Y; Niimi S; Nakagawa K; Minato K; Bungo M; Sasaki Y; Horichi N; Eguchi K; Saijo N
[Effects of recombinant human colony stimulating factor (rh-CSFs) on colony formation of lung cancer cell lines]
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(3 Pt 1):431-3.
1989: Tamura T; Shinkai T; Eguchi K; Sasaki Y; Fujiwara Y; Fukuda M; Ohe Y; Nakagawa K; Minato K; Saijo N
Phase II study of carboplatin in non-small cell lung cancer.
Japanese journal of clinical oncology 1989;19(1):51-5.
1989: Ohtsu A; Sasaki Y; Tamura T; Fujiwara Y; Ohe Y; Minato K; Nakagawa K; Bungo M; Saijo N
Inhibition of colony formation of drug-resistant human tumor cell lines by combinations of interleukin-2-activated killer cells and antitumor drugs.
Japanese journal of cancer research : Gann 1989;80(3):265-70.
1989: Tamura T; Sasaki Y; Shinkai T; Eguchi K; Sakurai M; Fujiwara Y; Nakagawa K; Minato K; Bungo M; Saijo N
Phase I study of combination therapy with interleukin 2 and beta-interferon in patients with advanced malignancy.
Cancer research 1989;49(3):730-5.
1988: Ozaki A; Nakano H; Minato K; Nakagawa K; Sasaki Y; Saijo N
The difference in surface phenotypes between cytotoxic lymphocytes induced in vivo by systemic administration of human recombinant interleukin-2 and lymphokine activated killer cells induced in vitro.
European journal of cancer & clinical oncology 1988;24(6):1055-60.
1988: Kanzawa F; Matsushima Y; Nakano H; Nakagawa K; Takahashi H; Sasaki Y; Saijo N
Antitumor activity of a new platinum compound (glycolate-o,o') diammineplatinum (II) (254-S), against non-small cell lung carcinoma grown in a human tumor clonogenic assay system.
Anticancer research 1988;8(3):323-7.
1988: Ishihara J; Saijo N; Kanzawa F; Matsushima Y; Sasaki Y; Takahashi H; Nakano H; Nakagawa K; Hong W S; Hoshi A
Augmentation of colony formation of cultured cell lines by pleural effusion from patients with lung cancer.
European journal of cancer & clinical oncology 1988;24(3):497-8.
1988: Hong W S; Saijo N; Sasaki Y; Minato K; Nakano H; Nakagawa K; Fujiwara Y; Nomura K; Twentyman P R
Establishment and characterization of cisplatin-resistant sublines of human lung cancer cell lines.
International journal of cancer. Journal international du cancer 1988;41(3):462-7.
1988: Tamura T; Saijo N; Shinkai T; Eguchi K; Sasaki Y; Sakurai M; Fujiwara Y; Nakano H; Nakagawa K; Minato K
Phase II study of carboplatin in small cell lung cancer.
Japanese journal of clinical oncology 1988;18(1):27-32.
1988: Sano T; Saijo N; Sasaki Y; Shinkai T; Eguchi K; Tamura T; Sakurai M; Takahashi H; Nakano H; Nakagawa K
Three schedules of recombinant human interleukin-2 in the treatment of malignancy: side effects and immunologic effects in relation to serum level.
Japanese journal of cancer research : Gann 1988;79(1):131-43.
1988: Shinkai T; Saijo N; Eguchi K; Sasaki Y; Tamura T; Sakurai M; Suga J; Nakano H; Nakagawa K; Hong W S
Cytogenetic effect of carboplatin on human lymphocytes.
Cancer chemotherapy and pharmacology 1988;21(3):203-7.
1988: Sakurai M; Iigo M; Tamura T; Otsu A; Sasaki Y; Nakano H; Nakagawa K; Minato K; Ohe Y; Saijo N
Comparative study of the antitumor effect of two types of murine recombinant interferons, (beta) and (gamma), against B16-F10 melanoma.
Cancer immunology, immunotherapy : CII 1988;26(2):109-13.
1988: Horiuchi N; Nakagawa K; Sasaki Y; Minato K; Fujiwara Y; Nezu K; Ohe Y; Saijo N
In vitro antitumor activity of mitomycin C derivative (RM-49) and new anticancer antibiotics (FK973) against lung cancer cell lines determined by tetrazolium dye (MTT) assay.
Cancer chemotherapy and pharmacology 1988;22(3):246-50.
1987: Sasaki Y; Kanzawa F; Takahashi H; Matsushima Y; Nakano H; Nakagawa K; Hong W S; Minato K; Fujiwara Y; Saijo N
In vitro antitumor effect of recombinant human tumor necrotizing factor on cultured human cancer cell lines and freshly isolated lung cancer cells by the human tumor clonogenic assay.
Investigational new drugs 1987;5(4):353-9.
1987: Taitou H; Sakurai M; Tamura T; Sasaki Y; Eguchi K; Shinkai T; Ookura H; Saijo N
[The changes in serum neuron-specific enolase in patients with small cell lung cancer]
Gan to kagaku ryoho. Cancer & chemotherapy 1987;14(11):3046-9.
1987: Nino S; Umehara H; Inoue I; Tamura T; Sasaki Y; Sakurai M; Shinkai T; Eguchi K; Saijo N; Suemasu K
[A randomized controlled trial of acute and delayed cisplatin-induced emesis with metoclopramide, dexamethasone and prochlorperazine]
Gan to kagaku ryoho. Cancer & chemotherapy 1987;14(10):2881-4.
1987: Kanzawa F; Matsushima Y; Chiang C D; Nakano H; Nakagawa K; Takahashi H; Sasaki Y; Saijo N
Comparative studies of pulse and continuous exposure in human tumor clonogenic assay.
Journal of pharmacobio-dynamics 1987;10(9):449-51.
1987: Sasaki Y; Ohta T; Tamura T; Eguchi K; Shinkai T; Noguchi M; Saijo N
A case report of pulmonary adenocarcinoma responding to (glycolato-0,0') diammineplatinum (II), a new platinum complex.
Japanese journal of clinical oncology 1987;17(3):285-90.
1987: Taguchi J; Saijo N; Miura K; Shinkai T; Eguchi K; Sasaki Y; Tamura T; Sakurai M; Minato K; Fujiwara Y
Prediction of hematologic toxicity of carboplatin by creatinine clearance rate.
Japanese journal of cancer research : Gann 1987;78(9):977-82.
1987: Nakano H; Saijo N; Sasaki Y; Takahashi H; Nakagwa K; Hong W S; Kanzawa F; Matsushima Y; Morikawa H; Sakurai M
[In vitro drug sensitivity test]
Gan to kagaku ryoho. Cancer & chemotherapy 1987;14(5 Pt 2):1620-8.
1987: Kanzawa F; Matsushima Y; Hamburger A W; Ishihara J; Sasaki Y; Shimizu E; Eguchi K; Shinkai T; Saijo N; Miyazawa N
Human tumor clonogenic assay for carcinoma of the lung. II. Factors that influence colony formation in soft agar.
Oncology 1987;44(3):150-5.
1987: Ishihara J; Saijo N; Sasaki Y; Nakano H; Ozaki A; Takahashi H; Sakurai M; Nakagawa K; Iigo M; Kanzawa F
The different effects of recombinant human tumor necrosis factor on rat fibrosarcoma sublines.
Cancer immunology, immunotherapy : CII 1987;24(3):185-9.
1986: Kanzawa F; Matsushima Y; Ishihara J; Shimizu E; Sasaki Y; Eguchi K; Shinkai T; Saijo N; Miyazawa N; Hamburger A W
In vitro chemosensitivity patterns of carcinoma of the lung in human tumor clonogenic assay.
Journal of pharmacobio-dynamics 1986;9(9):715-21.
1986: Sasaki Y; Saijo N; Lee Y C; Takahashi H; Ishihara J; Sakurai M; Sano T; Nakano H; Kanzawa F; Hoshi A
A bioassay of cisplatin by human tumor clonogenic assay.
Japanese journal of cancer research : Gann 1986;77(5):494-501.
1986: Saijo N; Ozaki A; Sakurai M; Ishihara J; Takahashi H; Sasaki Y; Hoshi A; Hamburger A W
Reduction of pulmonary metastases of B16 melanoma by human recombinant interleukin 2 and lymphokine-activated killer cells in immunosuppressed C57BL/6 mice receiving anticancer agent.
Japanese journal of cancer research : Gann 1986;77(5):487-93.
1986: Futami H; Saijo N; Sasaki Y; Sakurai M; Nomori H; Takahashi H; Ishihara J; Hoshi A; Koyama K; Hamburger A W
Differences of host immune response and of sensitivity to chemotherapeutic agents between two clones of rat fibrosarcoma with different metastatic potential.
Japanese journal of cancer research : Gann 1986;77(5):480-6.
1986: Fujita J; Saijo N; Sasaki Y; Futami H; Ishihara J; Takahashi H; Hoshi A; Hamburger A W
Detection of cytotoxicity of freshly obtained lymphocytes and of lymphocytes activated with recombinant interleukin II (rIL-2) against lung cancer cell lines by human tumor clonogenic assay (HTCA).
European journal of cancer & clinical oncology 1986;22(4):445-50.
1986: Saijo N; Ozaki A; Ishihara J; Sakurai M; Sasaki Y; Takahashi H; Sano T; Hoshi A
[Strategy of cancer treatment using human recombinant interleukin 2 and lymphokine activated killer cells]
Gan to kagaku ryoho. Cancer & chemotherapy 1986;13(4 Pt 2):1290-7.
1986: Lee Y C; Saijo N; Sasaki Y; Takahashi H; Sakurai M; Ishihara J; Sano T; Hoshi A; Chen K M; Hamburger A W
Antitumor effect of two-drug simultaneous or sequential use of cisplatin, vindesine or etoposide on human pulmonary adenocarcinoma cell lines in tumor clonogenic assay.
Japanese journal of cancer research : Gann 1986;77(3):312-8.
1985: Lee Y C; Saijo N; Sasaki Y; Takahashi H; Sakurai M; Ishihara J; Hoshi A; Chen K M; Hamburger A W
Clonogenic patterns of human pulmonary adenocarcinoma cell lines (PC-9, PC-13 and PC-14) and how they influence the results of test for chemosensitivity to cisplatin in the human tumor clonogenic assay.
Japanese journal of clinical oncology 1985;15(4):637-44.
1985: Kanzawa F; Matsushima Y; Ishihara J; Shimizu E; Sasaki Y; Saijo N; Miyazawa N
The use of human tumor clonogenic assay in predicting combination effect of cisplatin plus vindesine in carcinoma of the lung.
Journal of pharmacobio-dynamics 1985;8(10):885-8.
1985: Fujita J; Saijo N; Eguchi K; Shinkai T; Tominaga K; Sasaki Y; Futami H; Sakurai M; Ishihara J; Takahashi H
Phase II study of vindesine in patients with non-small cell lung cancer.
Japanese journal of cancer research : Gann 1985;76(9):902-5.
1985: Fujita J; Saijo N; Eguchi K; Shinkai T; Tominaga K; Sasaki Y; Sakurai M; Futami H; Ishihara J; Takahashi H
Preliminary phase II study of adriamycin (ADM) in patients with non-small cell lung cancer (NSCLC).
Japanese journal of clinical oncology 1985;15(2):365-8.

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