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Ikuo Saiki

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
56
Azuma, Ichiro
42
Sakurai, Hiroaki
39
Koizumi, Keiichi
29
Murata, Jun
23
Murakami, Koji
19
Kadota, Shigetoshi
17
Yamaura, Takeshi
16
Tezuka, Yasuhiro
15
Banskota, Arjun
13
Fuse, Hideki
11
Tsukada, Kazuhiro
10
Nagakawa, Osamu
10
Hayakawa, Yoshihiro
10
Yoo, Yung Choon
9
Ogasawara, M

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Publications

TOP 3
Zaidi Syed Faisal Haider; Yamamoto Takeshi; Refaat Alaa; Ahmed Kanwal; Sakurai Hiroaki; Saiki Ikuo; Kondo Takashi; Usmanghani Khan; Kadowaki Makoto; Sugiyama Toshiro
Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells.
Nishimura Miki; Shin Myoung-Sook; Singhirunnusorn Pattama; Suzuki Shunsuke; Kawanishi Miho; Koizumi Keiichi; Saiki Ikuo; Sakurai Hiroaki
TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling.
Shin Myoung-Sook; Shinghirunnusorn Pattama; Sugishima Yumiko; Nishimura Miki; Suzuki Shunsuke; Koizumi Keiichi; Saiki Ikuo; Sakurai Hiroaki
Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1.

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2009: Zaidi Syed Faisal Haider; Yamamoto Takeshi; Refaat Alaa; Ahmed Kanwal; Sakurai Hiroaki; Saiki Ikuo; Kondo Takashi; Usmanghani Khan; Kadowaki Makoto; Sugiyama Toshiro
Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells.
Helicobacter 2009;14(6):588-95.
2009: Nishimura Miki; Shin Myoung-Sook; Singhirunnusorn Pattama; Suzuki Shunsuke; Kawanishi Miho; Koizumi Keiichi; Saiki Ikuo; Sakurai Hiroaki
TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling.
Molecular and cellular biology 2009;29(20):5529-39.
2009: Shin Myoung-Sook; Shinghirunnusorn Pattama; Sugishima Yumiko; Nishimura Miki; Suzuki Shunsuke; Koizumi Keiichi; Saiki Ikuo; Sakurai Hiroaki
Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1.
Biochimica et biophysica acta 2009;1793(7):1156-64.
2009: Saiki Ikuo; Yamazaki Mikako; Matsumoto Kinzo
[JSPS-NRCT Core university program on natural medicine in pharmaceutical sciences]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2009;129(4):387-91.
2009: Yasuda Kenji; Nagakawa Osamu; Akashi Takuya; Fujiuchi Yasuyoshi; Koizumi Keiichi; Komiya Akira; Saiki Ikuo; Fuse Hideki
Serum active hepatocyte growth factor (AHGF) in benign prostatic disease and prostate cancer.
The Prostate 2009;69(4):346-51.
2009: Tsunoda Satoshi; Sakurai Hiroaki; Saito Yurika; Ueno Yoko; Koizumi Keiichi; Saiki Ikuo
Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability.
The American journal of pathology 2009;174(2):671-83.
2009: Senda Kazutaka; Koizumi Keiichi; Prangsaengtong Orawin; Minami Takayuki; Suzuki Shunsuke; Takasaki Ichiro; Tabuchi Yoshiaki; Sakurai Hiroaki; Doki Yoshinori; Misaki Takuro; Saiki Ikuo
Inducible capillary formation in lymphatic endothelial cells by blocking lipid phosphate phosphatase-3 activity.
Lymphatic research and biology 2009;7(2):69-74.
2008: Matsumoto Chinami; Kojima Tetsuko; Ogawa Kazuo; Kamegai Satoshi; Oyama Takuya; Shibagaki Yukari; Kawasaki Tetsuo; Fujinaga Hiroshi; Takahashi Kozo; Hikiami Hiroaki; Goto Hirozo; Kiga Chizuru; Koizumi Keiichi; Sakurai Hiroaki; Muramoto Hiroshi; Shimada Yutaka; Yamamoto Masahiro; Terasawa Katsutoshi; Takeda Shuichi; Saiki Ikuo
A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine.
Evidence-based complementary and alternative medicine : eCAM 2008;5(4):463-74.
2008: Kiga Chizuru; Sakurai Hiroaki; Goto Hirozo; Hayashi Kazuko; Shimada Yutaka; Saiki Ikuo
Proteomic identification of haptoglobin as a stroke plasma biomarker in spontaneously hypertensive stroke-prone rats.
Life sciences 2008;83(17-18):625-31.
2008: Ueno Yoko; Sakurai Hiroaki; Tsunoda Satoshi; Choo Min-Kyung; Matsuo Mitsuhiro; Koizumi Keiichi; Saiki Ikuo
Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells.
International journal of cancer. Journal international du cancer 2008;123(2):340-7.
2008: Hashimoto Isaya; Koizumi Keiichi; Tatematsu Mikiko; Minami Takayuki; Cho Seiji; Takeno Nobuhiro; Nakashima Akitoshi; Sakurai Hiroaki; Saito Shigeru; Tsukada Kazuhiro; Saiki Ikuo
Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells.
European journal of cancer (Oxford, England : 1990) 2008;44(7):1022-9.
2008: Andoh Tsugunobu; Sugiyama Kenji; Fujita Masahide; Iida Yuko; Nojima Hiroshi; Saiki Ikuo; Kuraishi Yasushi
Pharmacological evaluation of morphine and non-opioid analgesic adjuvants in a mouse model of skin cancer pain.
Biological & pharmaceutical bulletin 2008;31(3):520-2.
2008: Choo Min-Kyung; Sakurai Hiroaki; Kim Dong-Hyun; Saiki Ikuo
A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells.
Oncology reports 2008;19(3):595-600.
2008: Akashi Takuya; Koizumi Keiichi; Tsuneyama Koichi; Saiki Ikuo; Takano Yasuo; Fuse Hideki
Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer.
Cancer science 2008;99(3):539-42.
2008: Fujita Masahide; Andoh Tsugunobu; Saiki Ikuo; Kuraishi Yasushi
Involvement of endothelin and ET(A) endothelin receptor in mechanical allodynia in mice given orthotopic melanoma inoculation.
Journal of pharmacological sciences 2008;106(2):257-63.
2007: Saitoh Yurika; Koizumi Keiichi; Sakurai Hiroaki; Minami Takayuki; Saiki Ikuo
RANKL-induced down-regulation of CX3CR1 via PI3K/Akt signaling pathway suppresses Fractalkine/CX3CL1-induced cellular responses in RAW264.7 cells.
Biochemical and biophysical research communications 2007;364(3):417-22.
2007: Koizumi Keiichi; Hojo Shozo; Akashi Takuya; Yasumoto Kazuo; Saiki Ikuo
Chemokine receptors in cancer metastasis and cancer cell-derived chemokines in host immune response.
Cancer science 2007;98(11):1652-8.
2007: Ogawa Kazuo; Kojima Tetsuko; Matsumoto Chinami; Kamegai Satoshi; Oyama Takuya; Shibagaki Yukari; Muramoto Hiroshi; Kawasaki Tetsuo; Fujinaga Hiroshi; Takahashi Kozo; Hikiami Hiroaki; Goto Hirozo; Kiga Chizuru; Koizumi Keiichi; Sakurai Hiroaki; Shimada Yutaka; Yamamoto Masahiro; Terasawa Katsutoshi; Takeda Shuichi; Saiki Ikuo
Identification of a predictive biomarker for the beneficial effect of a Kampo (Japanese traditional) medicine keishibukuryogan in rheumatoid arthritis patients.
Clinical biochemistry 2007;40(15):1113-21.
2007: Suzuki Shunsuke; Singhirunnusorn Pattama; Mori Akinori; Yamaoka Shoji; Kitajima Isao; Saiki Ikuo; Sakurai Hiroaki
Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB.
The Journal of biological chemistry 2007;282(35):25177-81.
2007: Matsuo Mitsuhiro; Yamada Sanae; Koizumi Keiichi; Sakurai Hiroaki; Saiki Ikuo
Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells.
European journal of cancer (Oxford, England : 1990) 2007;43(11):1748-54.
2007: Koizumi Keiichi; Kozawa Yoko; Ohashi Yasukata; Nakamura Eliane Shizuka; Aozuka Yasushi; Sakurai Hiroaki; Ichiki Katsuyuki; Doki Yoshinori; Misaki Takuro; Saiki Ikuo
CCL21 promotes the migration and adhesion of highly lymph node metastatic human non-small cell lung cancer Lu-99 in vitro.
Oncology reports 2007;17(6):1511-6.
2007: Matsuo Mitsuhiro; Sakurai Hiroaki; Koizumi Keiichi; Saiki Ikuo
Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells.
Cancer letters 2007;251(2):288-95.
2007: Hojo Shozo; Koizumi Keiichi; Tsuneyama Koichi; Arita Yoshihisa; Cui Zhengguo; Shinohara Kanna; Minami Takayuki; Hashimoto Isaya; Nakayama Takashi; Sakurai Hiroaki; Takano Yasuo; Yoshie Osamu; Tsukada Kazuhiro; Saiki Ikuo
High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer.
Cancer research 2007;67(10):4725-31.
2007: Singhirunnusorn Pattama; Ueno Yoko; Matsuo Mitsuhiro; Suzuki Shunsuke; Saiki Ikuo; Sakurai Hiroaki
Transient suppression of ligand-mediated activation of epidermal growth factor receptor by tumor necrosis factor-alpha through the TAK1-p38 signaling pathway.
The Journal of biological chemistry 2007;282(17):12698-706.
2006: Choo Min-Kyung; Kawasaki Noritaka; Singhirunnusorn Pattama; Koizumi Keiichi; Sato Shintaro; Akira Shizuo; Saiki Ikuo; Sakurai Hiroaki
Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.
Molecular cancer therapeutics 2006;5(12):2970-6.
2006: Mori Akinori; Sakurai Hiroaki; Choo Min-Kyung; Obi Ryosuke; Koizumi Keiichi; Yoshida Chiho; Shimada Yutaka; Saiki Ikuo
Severe pulmonary metastasis in obese and diabetic mice.
International journal of cancer. Journal international du cancer 2006;119(12):2760-7.
2006: Matsuo Mitsuhiro; Koizumi Keiichi; Yamada Sanae; Tomi Masatoshi; Takahashi Ri-ichi; Ueda Masatsugu; Terasaki Tetsuya; Obinata Masuo; Hosoya Ken-ichi; Ohtani Osamu; Saiki Ikuo
Establishment and characterization of conditionally immortalized endothelial cell lines from the thoracic duct and inferior vena cava of tsA58/EGFP double-transgenic rats.
Cell and tissue research 2006;326(3):749-58.
2006: Fukasawa Kazuteru; Fujii Hideji; Saitoh Yurika; Koizumi Keiichi; Aozuka Yasushi; Sekine Keiko; Yamada Masatoshi; Saiki Ikuo; Nishikawa Kiyohiro
Aminopeptidase N (APN/CD13) is selectively expressed in vascular endothelial cells and plays multiple roles in angiogenesis.
Cancer letters 2006;243(1):135-43.
2006: Choo Min-Kyung; Sakurai Hiroaki; Koizumi Keiichi; Saiki Ikuo
TAK1-mediated stress signaling pathways are essential for TNF-alpha-promoted pulmonary metastasis of murine colon cancer cells.
International journal of cancer. Journal international du cancer 2006;118(11):2758-64.
2006: Suzuki Shunsuke; Singhirunnusorn Pattama; Nakano Hiroyasu; Doi Takahiro; Saiki Ikuo; Sakurai Hiroaki
Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2.
FEBS letters 2006;580(13):3257-62.
2006: Ogawa Hirofumi; Gomi Tomoharu; Nishizawa Mikio; Hayakawa Yumiko; Endo Shunro; Hayashi Kyoko; Ochiai Hiroshi; Takusagawa Fusao; Pitot Henry C; Mori Hisashi; Sakurai Hiroaki; Koizumi Keiichi; Saiki Ikuo; Oda Hirofumi; Fujishita Takashi; Miwa Toshiro; Maruyama Muneharu; Kobayashi Masashi
Enzymatic and biochemical properties of a novel human serine dehydratase isoform.
Biochimica et biophysica acta 2006;1764(5):961-71.
2006: Saitoh Yurika; Koizumi Keiichi; Minami Takayuki; Sekine Keiko; Sakurai Hiroaki; Saiki Ikuo
A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells.
Biological & pharmaceutical bulletin 2006;29(4):709-12.
2006: Matsuo Mitsuhiro; Sakurai Hiroaki; Ueno Yoko; Ohtani Osamu; Saiki Ikuo
Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib.
Cancer science 2006;97(2):155-62.
2006: Nakamura Eliane Shizuka; Koizumi Keiichi; Kobayashi Mitsuo; Saitoh Yurika; Arita Yoshihisa; Nakayama Takashi; Sakurai Hiroaki; Yoshie Osamu; Saiki Ikuo
RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4.
Clinical & experimental metastasis 2006;23(1):9-18.
2005: Sakurai Hiroaki; Singhirunnusorn Pattama; Shimotabira Emi; Chino Atsushi; Suzuki Shunsuke; Koizumi Keiichi; Saiki Ikuo
TAK1-mediated transcriptional activation of CD28-responsive element and AP-1-binding site within the IL-2 promoter in Jurkat T cells.
FEBS letters 2005;579(29):6641-6.
2005: Choo Min-Kyung; Sakurai Hiroaki; Koizumi Keiichi; Saiki Ikuo
Stimulation of cultured colon 26 cells with TNF-alpha promotes lung metastasis through the extracellular signal-regulated kinase pathway.
Cancer letters 2005;230(1):47-56.
2005: Ueda Yasuji; Yamagishi Takehiro; Samata Kazunori; Hirayama Noriko; Aozuka Yasushi; Tanaka Makoto; Nakaike Shiro; Saiki Ikuo
Antitumor effects of synthetic VEGF-receptor binding antagonist, VGA1155.
Anticancer research 2005;25(6B):3973-7.
2005: Tega Eiji; Kiga Chizuru; Chino Atsushi; Sakurai Hiroaki; Koizumi Keiichi; Tani Tadato; Saiki Ikuo
A newly devised formulation for self-medication enhances interferon-gamma production and proliferation of splenic lymphocytes.
Biological & pharmaceutical bulletin 2005;28(10):1869-72.
2005: Kiga Chizuru; Nakagawa Takako; Koizumi Keiichi; Sakurai Hiroaki; Shibagaki Yukari; Ogawa Kazuo; Goto Hirozo; Saiki Ikuo
Expression patterns of plasma proteins in spontaneously diabetic rats after oral administration of a Kampo medicine, Hachimi-jio-gan, using SELDI ProteinChip platform.
Biological & pharmaceutical bulletin 2005;28(6):1031-7.
2005: Nagakawa Osamu; Junicho Akira; Akashi Takuya; Koizumi Keiichi; Matsuda Tadashi; Fuse Hideki; Saiki Ikuo
Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide stimulate interleukin-6 production in prostate cancer cells and prostatic epithelial cells.
Oncology reports 2005;13(6):1217-21.
2005: Lirdprapamongkol Kriengsak; Sakurai Hiroaki; Kawasaki Noritaka; Choo Min-Kyung; Saitoh Yurika; Aozuka Yasushi; Singhirunnusorn Pattama; Ruchirawat Somsak; Svasti Jisnuson; Saiki Ikuo
Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;25(1):57-65.
2005: Ueno Y; Sakurai H; Matsuo M; Choo M K; Koizumi K; Saiki I
Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib.
British journal of cancer 2005;92(9):1690-5.
2005: Chino Atsushi; Sakurai Hiroaki; Choo Min-Kyung; Koizumi Keiichi; Shimada Yutaka; Terasawa Katsutoshi; Saiki Ikuo
Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages.
International immunopharmacology 2005;5(5):871-82.
2005: Yoshioka Isaku; Tsuchiya Yasunori; Aozuka Yasushi; Onishi Yasuharu; Sakurai Hiroaki; Koizumi Keiichi; Tsukada Kazuhiro; Saiki Ikuo
Urinary trypsin inhibitor suppresses surgical stress-facilitated lung metastasis of murine colon 26-L5 carcinoma cells.
Anticancer research 2005;25(2A):815-20.
2005: Singhirunnusorn Pattama; Suzuki Shunsuke; Kawasaki Noritaka; Saiki Ikuo; Sakurai Hiroaki
Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.
The Journal of biological chemistry 2005;280(8):7359-68.
2004: Aozuka Yasushi; Koizumi Keiichi; Saitoh Yurika; Ueda Yasuji; Sakurai Hiroaki; Saiki Ikuo
Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice.
Cancer letters 2004;216(1):35-42.
2004: Nagakawa Osamu; Akashi Takuya; Hayakawa Yoshihiro; Junicho Akira; Koizumi Keiichi; Fujiuchi Yasuyoshi; Furuya Yuzo; Matsuda Tadashi; Fuse Hideki; Saiki Ikuo
Differential expression of integrin subunits in DU-145/AR prostate cancer cells.
Oncology reports 2004;12(4):837-41.
2004: Ueda Yasuji; Yamagishi Takehiro; Ikeya Hisao; Hirayama Noriko; Itokawa Takashi; Aozuka Yasushi; Samata Kazunori; Nakaike Shiro; Tanaka Makoto; Ono Mayumi; Saiki Ikuo
VGA1155, a novel binding antagonist of VEGF, inhibits angiogenesis in vitro and in vivo.
Anticancer research 2004;24(5A):3009-17.
2004: Majima Takami; Yamada Tomohiro; Tega Eiji; Sakurai Hiroaki; Saiki Ikuo; Tani Tadato
Pharmaceutical evaluation of liquorice before and after roasting in mice.
The Journal of pharmacy and pharmacology 2004;56(5):589-95.
2004: Saiki Ikuo
[Screening for inhibitors of tumor invasion into basement membranes]
Gan to kagaku ryoho. Cancer & chemotherapy 2004;31(4):512-7.
2004: Nakamura Eliane Shizuka; Koizumi Keiichi; Kobayashi Mitsuo; Saiki Ikuo
Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270.
Cancer science 2004;95(1):25-31.
2003: Ueda Jun-Ya; Tezuka Yasuhiro; Banskota Arjun H; Tran Quan Le; Tran Qui Kim; Saiki Ikuo; Kadota Shigetoshi
Constituents of the Vietnamese medicinal plant Streptocaulon juventas and their antiproliferative activity against the human HT-1080 fibrosarcoma cell line.
Journal of natural products 2003;66(11):1427-33.
2003: Ueda Yasuji; Yamagishi Takehiro; Samata Kazunori; Ikeya Hisao; Hirayama Noriko; Takashima Hajime; Nakaike Shiro; Tanaka Makoto; Saiki Ikuo
A novel low molecular weight antagonist of vascular endothelial growth factor receptor binding: VGA1155.
Molecular cancer therapeutics 2003;2(11):1105-11.
2003: Ueda Jun-Ya; Tezuka Yasuhiro; Banskota Arjun Hari; Tran Quan Le; Tran Qui Kim; Saiki Ikuo; Kadota Shigetoshi
Antiproliferative activity of cardenolides isolated from Streptocaulon juventas.
Biological & pharmaceutical bulletin 2003;26(10):1431-5.
2003: Nagakawa Osamu; Fujiuchi Yasuyoshi; Fuse Hideki; Saiki Ikuo
Differential effect of chromogranin A fragments on invasion and growth of prostate cancer cells in vitro.
Urology 2003;62(3):553-8.
2003: Sakurai Hiroaki; Suzuki Shunsuke; Kawasaki Noritaka; Nakano Hiroyasu; Okazaki Tatsuma; Chino Atsushi; Doi Takahiro; Saiki Ikuo
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.
The Journal of biological chemistry 2003;278(38):36916-23.
2003: Lee Soo Jin; Ohashi Yasukata; Sakurai Hiroaki; Saiki Ikuo
TAC-101 inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma.
Cancer letters 2003;198(2):169-77.
2003: Yamamoto Yutaka; Majima Takami; Saiki Ikuo; Tani Tadato
Pharmaceutical evaluation of Glycyrrhiza uralensis roots cultivated in eastern Nei-Meng-Gu of China.
Biological & pharmaceutical bulletin 2003;26(8):1144-9.
2003: Lee S J; Sakurai H; Oshima K; Kim S H; Saiki I
Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b.
European journal of cancer (Oxford, England : 1990) 2003;39(11):1632-41.
2003: Fujiuchi Yasuyoshi; Nagakawa Osamu; Murakami Koji; Fuse Hideki; Saiki Ikuo
Effect of hepatocyte growth factor on invasion of prostate cancer cell lines.
Oncology reports 2003;10(4):1001-6.
2003: Matsuo Mitsuhiro; Sakurai Hiroaki; Saiki Ikuo
ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, shows antimetastatic activity using a hepatocellular carcinoma model.
Molecular cancer therapeutics 2003;2(6):557-61.
2003: Tsuchiya Yasunori; Sawada Shigeaki; Yoshioka Isaku; Ohashi Yasukata; Matsuo Mitsuhiro; Harimaya Yuko; Tsukada Kazuhiro; Saiki Ikuo
Increased surgical stress promotes tumor metastasis.
Surgery 2003;133(5):547-55.
2003: Nagaoka Takema; Banskota Arjun H; Tezuka Yasuhiro; Harimaya Yuko; Koizumi Keiichi; Saiki Ikuo; Kadota Shigetoshi
Inhibitory effects of caffeic acid phenethyl ester analogues on experimental lung metastasis of murine colon 26-L5 carcinoma cells.
Biological & pharmaceutical bulletin 2003;26(5):638-41.
2003: Kuraishi Yasushi; Iida Yuko; Zhang Hong-Wei; Uehara Saori; Nojima Hiroshi; Murata Jun; Saiki Ikuo; Takahata Hiroki; Ouchi Hidekazu
Suppression by gabapentin of pain-related mechano-responses in mice given orthotopic tumor inoculation.
Biological & pharmaceutical bulletin 2003;26(4):550-2.
2003: Zhang Hong-Wei; Iida Yuko; Andoh Tsugunobu; Nojima Hiroshi; Murata Jun; Saiki Ikuo; Kuraishi Yasushi
Mechanical hypersensitivity and alterations in cutaneous nerve fibers in a mouse model of skin cancer pain.
Journal of pharmacological sciences 2003;91(2):167-70.
2003: Lee Soo Jin; Saiki Ikuo; Hayakawa Yoshihiro; Nunome Shinyu; Yamada Haruki; Kim Sung-Hoon
Antimetastatic and immunomodulating properties of a new herbal prescription, Bojung-bangam-tang.
International immunopharmacology 2003;3(2):147-57.
2003: Nakamura Eliane Shizuka; Koizumi Keiichi; Yamaura Takeshi; Saiki Ikuo
Anti-tumor angiogenic effect of a matrix metalloproteinase inhibitor MMI270.
Anticancer research 2003;23(1A):411-7.
2003: Ohashi Yasukata; Tsuchiya Yasunori; Koizumi Keiichi; Sakurai Hiroaki; Saiki Ikuo
Prevention of intrahepatic metastasis by curcumin in an orthotopic implantation model.
Oncology 2003;65(3):250-8.
2002: Harimaya Yuko; Koizumi Keiichi; Andoh Tsugunobu; Nojima Hiroshi; Kuraishi Yasushi; Saiki Ikuo
Potential ability of morphine to inhibit the adhesion, invasion and metastasis of metastatic colon 26-L5 carcinoma cells.
Cancer letters 2002;187(1-2):121-7.
2002: Nagaoka Takema; Banskota Arjun H; Tezuka Yasuhiro; Saiki Ikuo; Kadota Shigetoshi
Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-metastatic murine colon 26-L5 carcinoma cell line.
Bioorganic & medicinal chemistry 2002;10(10):3351-9.
2002: Hayakawa Yoshihiro; Takeda Kazuyoshi; Yagita Hideo; Smyth Mark J; Van Kaer Luc; Okumura Ko; Saiki Ikuo
IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide.
Blood 2002;100(5):1728-33.
2002: Ueda Jun-ya; Tezuka Yasuhiro; Banskota Arjun Hari; Le Tran Quan; Tran Qui Kim; Harimaya Yuko; Saiki Ikuo; Kadota Shigetoshi
Antiproliferative activity of Vietnamese medicinal plants.
Biological & pharmaceutical bulletin 2002;25(6):753-60.
2002: Koizumi Keiichi; Saiki Ikuo
[The group of adhesion molecules involved in the metastasis of the lung cancer mechanism]
Nippon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 5():97-102.
2002: Tran Quan Le; Adnyana I Ketut; Tezuka Yasuhiro; Harimaya Yuko; Saiki Ikuo; Kurashige Youichi; Tran Qui Kim; Kadota Shigetoshi
Hepatoprotective effect of majonoside R2, the major saponin from Vietnamese ginseng (Panax vietnamensis).
Planta medica 2002;68(5):402-6.
2002: Sasamura Takashi; Nakamura Shigenobu; Iida Yuko; Fujii Hideki; Murata Jun; Saiki Ikuo; Nojima Hiroshi; Kuraishi Yasushi
Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation.
European journal of pharmacology 2002;441(3):185-91.
2002: Sawada Shigeaki; Murakami Koji; Yamaura Takeshi; Mitani Noriyasu; Tsukada Kazuhiro; Saiki Ikuo
Therapeutic and analysis model of intrahepatic metastasis reflects clinical behavior of hepatocellular carcinoma.
Japanese journal of cancer research : Gann 2002;93(2):190-7.
2002: Nagakawa Osamu; Murata Jun; Junicho Akira; Matsuda Tadashi; Fujiuchi Yasuyoshi; Fuse Hideki; Saiki Ikuo
Vasoactive intestinal peptide (VIP) enhances the cell motility of androgen receptor-transfected DU-145 prostate cancer cells (DU-145/AR).
Cancer letters 2002;176(1):93-9.
2002: Tsuchiya Yasunori; Sawada Shigeaki; Tsukada Kazuhiro; Saiki Ikuo
A new pseudo-peptide of Arg-Gly-Asp (RGD) inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma.
International journal of oncology 2002;20(2):319-24.
2001: Muraishi Y; Mitani N; Fuse H; Saiki I
Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinoma.
Anticancer research 2001;21(6A):3845-52.
2001: Tran Q L; Tezuka Y; Banskota A H; Tran Q K; Saiki I; Kadota S
New spirostanol steroids and steroidal saponins from roots and rhizomes of Dracaena angustifolia and their antiproliferative activity.
Journal of natural products 2001;64(9):1127-32.
2001: Wu W; Murata J; Hayashi K; Yamaura T; Mitani N; Saiki I
Social isolation stress impairs the resistance of mice to experimental liver metastasis of murine colon 26-L5 carcinoma cells.
Biological & pharmaceutical bulletin 2001;24(7):772-6.
2001: Sawada S; Murakami K; Murata J; Tsukada K; Saiki I
Accumulation of extracellular matrix in the liver induces high metastatic potential of hepatocellular carcinoma to the lung.
International journal of oncology 2001;19(1):65-70.
2001: Hayakawa Y; Takeda K; Yagita H; Kakuta S; Iwakura Y; Van Kaer L; Saiki I; Okumura K
Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide.
European journal of immunology 2001;31(6):1720-7.
2001: Ali M S; Banskota A H; Tezuka Y; Saiki I; Kadota S
Antiproliferative activity of diarylheptanoids from the seeds of Alpinia blepharocalyx.
Biological & pharmaceutical bulletin 2001;24(5):525-8.
2001: Hayakawa Y; Takeda K; Yagita H; Van Kaer L; Saiki I; Okumura K
Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6012-8.
2001: Sawada S; Murakami K; Yamaura T; Sakamoto T; Ogawa K; Tsukada K; Saiki I
Intrahepatic metastasis by orthotopic implantation of a fragment of murine hepatoma and its related molecules.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2001;22(3):154-61.
2001: Mitani N; Murakami K; Yamaura T; Ikeda T; Saiki I
Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma.
Cancer letters 2001;165(1):35-42.
2001: Tatsumi T; Yamada T; Nagai H; Terasawa K; Tani T; Nunome S; Saiki I
A Kampo formulation: Byakko-ka-ninjin-to (Bai-Hu-Jia-Ren-Sheng-Tang) inhibits IgE-mediated triphasic skin reaction in mice: the role of its constituents in expression of the efficacy.
Biological & pharmaceutical bulletin 2001;24(3):284-90.
2001: Nagakawa O; Ogasawara M; Murata J; Fuse H; Saiki I
Effect of prostatic neuropeptides on migration of prostate cancer cell lines.
International journal of urology : official journal of the Japanese Urological Association 2001;8(2):65-70.
2000: Tezuka Y; Stampoulis P; Banskota A H; Awale S; Tran K Q; Saiki I; Kadota S
Constituents of the Vietnamese medicinal plant Orthosiphon stamineus.
Chemical & pharmaceutical bulletin 2000;48(11):1711-9.
2000: Muraishi Y; Mitani N; Yamaura T; Fuse H; Saiki I
Effect of interferon-alpha A/D in combination with the Japanese and Chinese traditional herbal medicine juzen-taiho-to on lung metastasis of murine renal cell carcinoma.
Anticancer research 2000;20(5A):2931-7.
2000: Yamaura T; Murakami K; Doki Y; Sugiyama S; Misaki T; Yamada Y; Saiki I
Solitary lung tumors and their spontaneous metastasis in athymic nude mice orthotopically implanted with human non-small cell lung cancer.
Neoplasia (New York, N.Y.) 2000;2(4):315-24.
2000: Ikeda T; Murakami K; Sakukaw R; Hayakawa Y; Saiki I
Characterization of a liver metastatic variant of murine K1735M2 melanoma cells.
In vivo (Athens, Greece) 2000;14(4):519-27.
2000: Nagakawa O; Murakami K; Yamaura T; Fujiuchi Y; Murata J; Fuse H; Saiki I
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) on prostate cancer cell lines.
Cancer letters 2000;155(2):173-9.
2000: Saiki I
A Kampo medicine "Juzen-taiho-to"--prevention of malignant progression and metastasis of tumor cells and the mechanism of action.
Biological & pharmaceutical bulletin 2000;23(6):677-88.
2000: Banskota A H; Tezuka Y; Adnyana I K; Xiong Q; Hase K; Tran K Q; Tanaka K; Saiki I; Kadota S
Hepatoprotective effect of Combretum quadrangulare and its constituents.
Biological & pharmaceutical bulletin 2000;23(4):456-60.
2000: Banskota A H; Tezuka Y; Tran K Q; Tanaka K; Saiki I; Kadota S
Methyl quadrangularates A-D and related triterpenes from Combretum quadrangulare.
Chemical & pharmaceutical bulletin 2000;48(4):496-504.
2000: Murakami K; Matsuura T; Hasumura S; Nagamori S; Yamada Y; Saiki I
Involvement of insulin-like growth factor binding protein-3 in the retinoic acid receptor-alpha-mediated inhibition of hepatocellular carcinoma cell proliferation.
Cancer letters 2000;151(1):63-70.
2000: Wu W; Yamaura T; Murakami K; Murata J; Matsumoto K; Watanabe H; Saiki I
Social isolation stress enhanced liver metastasis of murine colon 26-L5 carcinoma cells by suppressing immune responses in mice.
Life sciences 2000;66(19):1827-38.
2000: Satoh T; Tahara E; Yamada T; Watanabe C; Itoh T; Terasawa K; Nagai H; Saiki I
Differential effect of antiallergic drugs on IgE-mediated cutaneous reaction in passively sensitized mice.
Pharmacology 2000;60(2):97-104.
2000: Banskota A H; Tezuka Y; Tran K Q; Tanaka K; Saiki I; Kadota S
Thirteen novel cycloartane-type triterpenes from Combretum quadrangulare.
Journal of natural products 2000;63(1):57-64.
2000: Ichiki K; Mitani N; Doki Y; Hara H; Misaki T; Saiki I
Regulation of activator protein-1 activity in the mediastinal lymph node metastasis of lung cancer.
Clinical & experimental metastasis 2000;18(7):539-45.
2000: Wu W; Murata J; Murakami K; Yamaura T; Hayashi K; Saiki I
Social isolation stress augments angiogenesis induced by colon 26-L5 carcinoma cells in mice.
Clinical & experimental metastasis 2000;18(1):1-10.
1999: Gewali M B; Tezuka Y; Banskota A H; Ali M S; Saiki I; Dong H; Kadota S
Epicalyxin F and calyxin I: two novel antiproliferative diarylheptanoids from the seeds of Alpinia blepharocalyx.
Organic letters 1999;1(11):1733-6.
1999: Yamaura T; Doki Y; Murakami K; Saiki I
Model for mediastinal lymph node metastasis produced by orthotopic intrapulmonary implantation of lung cancer cells in mice.
Human cell : official journal of Human Cell Research Society 1999;12(4):197-204.
1999: Nagakawa O; Murakami K; Ogasawara M; Murata J; Fuse H; Saiki I
Effect of chromogranin A (pancreastatin) fragment on invasion of prostate cancer cells.
Cancer letters 1999;147(1-2):207-13.
1999: Tahara E; Satoh T; Toriizuka K; Nagai H; Nunome S; Shimada Y; Itoh T; Terasawa K; Saiki I
Effect of Shimotsu-to (a Kampo medicine, Si-Wu-Tang) and its constituents on triphasic skin reaction in passively sensitized mice.
Journal of ethnopharmacology 1999;68(1-3):219-28.
1999: Murakami K; Sakukawa R; Ikeda T; Matsuura T; Hasumura S; Nagamori S; Yamada Y; Saiki I
Invasiveness of hepatocellular carcinoma cell lines: contribution of membrane-type 1 matrix metalloproteinase.
Neoplasia (New York, N.Y.) 1999;1(5):424-30.
1999: Stampoulis P; Tezuka Y; Banskota A H; Tran K Q; Saiki I; Kadota S
Staminolactones A and B and norstaminol A: three highly oxygenated staminane-type diterpenes from Orthosiphon stamineus.
Organic letters 1999;1(9):1367-70.
1999: Wu W; Murakami K; Koketsu M; Yamada Y; Saiki I
Induction of apoptosis in human gastric adenocarcinoma cells by two novel organoselenium compounds, TS-2 and TS-6.
Anticancer research 1999;19(6B):5375-81.
1999: Murakami K; Yamaura T; Suda K; Ohie S; Shibata J; Toko T; Yamada Y; Saiki I
TAC-101 (4-[3,5-bis(trimethylsilyl)benzamido]benzoic acid) inhibits spontaneous mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma.
Japanese journal of cancer research : Gann 1999;90(11):1254-61.
1999: Murakami K; Sakukawa R; Sano M; Hashimoto A; Shibata J; Yamada Y; Saiki I
Inhibition of angiogenesis and intrahepatic growth of colon cancer by TAC-101.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2304-10.
1999: Saiki I; Yamaura T; Ohnishi Y; Hayakawa Y; Komatsu Y; Nunome S
HPLC analysis of juzen-taiho-to and its variant formulations and their antimetastatic efficacies.
Chemical & pharmaceutical bulletin 1999;47(8):1170-4.
1999: Ogasawara M; Murata J; Kamitani Y; Hayashi K; Saiki I
Inhibition by vasoactive intestinal polypeptide (VIP) of angiogenesis induced by murine Colon 26-L5 carcinoma cells metastasized in liver.
Clinical & experimental metastasis 1999;17(4):283-91.
1999: Murata J; Saiki I
[Tumor metastasis and cell adhesion molecules]
Gan to kagaku ryoho. Cancer & chemotherapy 1999;26(5):715-23.
1999: Doki Y; Murakami K; Yamaura T; Sugiyama S; Misaki T; Saiki I
Mediastinal lymph node metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in mice.
British journal of cancer 1999;79(7-8):1121-6.
1999: Murata J; Ayukawa K; Ogasawara M; Watanabe H; Saiki I
Induction of autocrine factor inhibiting cell motility from murine B16-BL6 melanoma cells by alpha-melanocyte stimulating hormone.
International journal of cancer. Journal international du cancer 1999;80(6):889-95.
1999: Watanabe C; Satoh T; Tahara E; Murakami K; Hayashi K; Hase K; Andoh T; Kuraishi Y; Kadota S; Nagai H; Saiki I
Inhibitory mechanisms of glycoprotein fraction derived from Miscanthus sinensis for the immediate phase response of an IgE-mediated cutaneous reaction.
Biological & pharmaceutical bulletin 1999;22(1):26-30.
1999: Wu W; Yamaura T; Murakami K; Ogasawara M; Hayashi K; Murata J; Saiki I
Involvement of TNF-alpha in enhancement of invasion and metastasis of colon 26-L5 carcinoma cells in mice by social isolation stress.
Oncology research 1999;11(10):461-9.
1998: Banskota A H; Tezuka Y; Phung L K; Tran K Q; Saiki I; Miwa Y; Taga T; Kadota S
Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare.
Bioorganic & medicinal chemistry letters 1998;8(24):3519-24.
1998: Nagakawa O; Ogasawara M; Fujii H; Murakami K; Murata J; Fuse H; Saiki I
Effect of prostatic neuropeptides on invasion and migration of PC-3 prostate cancer cells.
Cancer letters 1998;133(1):27-33.
1998: Ikeda T; Murakami K; Hayakawa Y; Fujii H; Ohkoshi M; Saiki I
Anti-invasive activity of synthetic serine protease inhibitors and its combined effect with a matrix metalloproteinase inhibitor.
Anticancer research 1998;18(6A):4259-65.
1998: Hayakawa Y; Fujii H; Hase K; Ohnishi Y; Sakukawa R; Kadota S; Namba T; Saiki I
Anti-metastatic and immunomodulating properties of the water extract from Celosia argentea seeds.
Biological & pharmaceutical bulletin 1998;21(11):1154-9.
1998: Murakami K; Matsuura T; Sano M; Hashimoto A; Yonekura K; Sakukawa R; Yamada Y; Saiki I
4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) inhibits the intrahepatic spread of hepatocellular carcinoma and prolongs the life-span of tumor-bearing animals.
Clinical & experimental metastasis 1998;16(7):633-43.
1998: Mishima T; Murata J; Toyoshima M; Fujii H; Nakajima M; Hayashi T; Kato T; Saiki I
Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis.
Clinical & experimental metastasis 1998;16(6):541-50.
1998: Onishi Y; Yamaura T; Tauchi K; Sakamoto T; Tsukada K; Nunome S; Komatsu Y; Saiki I
Expression of the anti-metastatic effect induced by Juzen-taiho-to is based on the content of Shimotsu-to constituents.
Biological & pharmaceutical bulletin 1998;21(7):761-5.
1998: Banskota A H; Tezuka Y; Prasain J K; Matsushige K; Saiki I; Kadota S
Chemical constituents of Brazilian propolis and their cytotoxic activities.
Journal of natural products 1998;61(7):896-900.
1998: Wakabayashi C; Murakami K; Hasegawa H; Murata J; Saiki I
An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells.
Biochemical and biophysical research communications 1998;246(3):725-30.
1998: Ohnishi Y; Fujii H; Hayakawa Y; Sakukawa R; Yamaura T; Sakamoto T; Tsukada K; Fujimaki M; Nunome S; Komatsu Y; Saiki I
Oral administration of a Kampo (Japanese herbal) medicine Juzen-taiho-to inhibits liver metastasis of colon 26-L5 carcinoma cells.
Japanese journal of cancer research : Gann 1998;89(2):206-13.
1998: Fujii H; Inobe M; Hayakawa Y; Kimura F; Murakami M; Onishi Y; Azuma I; Uede T; Saiki I
Vaccination with B7-1+ tumor and anti-adhesion therapy with RGD pseudo-peptide (FC-336) efficiently induce anti-metastatic effect.
Clinical & experimental metastasis 1998;16(2):141-8.
1998: Ohnishi Y; Fujii H; Murakami K; Sakamoto T; Tsukada K; Fujimaki M; Kojima M; Saiki I
A new pseudo-peptide analogue of the Arg-Gly-Asp (RGD) sequence inhibits liver metastasis of colon 26-L5 carcinoma cells.
Cancer letters 1998;124(2):157-63.
1998: Watanabe C; Hase K; Oku T; Koizumi F; Kadota S; Nagai H; Namba T; Saiki I
Effect of spikelets of Miscanthus sinensis on IgE-mediated biphasic cutaneous reaction in mice.
Planta medica 1998;64(1):12-7.
1998: Fujii H; Nishikawa N; Komazawa H; Suzuki M; Kojima M; Itoh I; Obata A; Ayukawa K; Azuma I; Saiki I
A new pseudo-peptide of Arg-Gly-Asp (RGD) with inhibitory effect on tumor metastasis and enzymatic degradation of extracellular matrix.
Clinical & experimental metastasis 1998;16(1):94-104.
1998: Ogasawara M; Murata J; Ayukawa K; Saiki I
Inhibitory effect of vasoactive intestinal polypeptide (VIP) on experimental liver metastasis by murine colon 26-L5 carcinoma cells.
Oncology research 1998;10(7):361-70.
1998: Sakukawa R; Murakami K; Ikeda T; Yamada Y; Saiki I
Effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) on the liver metastasis of colon 26-L5 carcinoma cells.
Oncology research 1998;10(6):287-93.
1998: Viroonchatapan E; Sato H; Ueno M; Adachi I; Murata J; Saiki I; Tazawa K; Horikoshi I
Microdialysis assessment of 5-fluorouracil release from thermosensitive magnetoliposomes induced by an electromagnetic field in tumor-bearing mice.
Journal of drug targeting 1998;5(5):379-90.
1997: Ogasawara M; Murata J; Ayukawa K; Saiki I
Differential effect of intestinal neuropeptides on invasion and migration of colon carcinoma cells in vitro.
Cancer letters 1997;119(1):125-30.
1997: Nakanishi K; Une Y; Saiki I; Haneda T; Okubo H; Tomioka N; Shimamura T; Kamiyama T; Matsushita M
[Clinicopathological study on early recurrent hepatoma and its treatment]
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24 Suppl 2():269-72.
1997: Saito K; Oku T; Ata N; Miyashiro H; Hattori M; Saiki I
A modified and convenient method for assessing tumor cell invasion and migration and its application to screening for inhibitors.
Biological & pharmaceutical bulletin 1997;20(4):345-8.
1997: Saiki I
[Screening for the inhibitors of tumor invasion into basement membranes]
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(2):187-95.
1997: Murata J; Ayukawa K; Ogasawara M; Fujii H; Saiki I
Alpha-melanocyte-stimulating hormone blocks invasion of reconstituted basement membrane (Matrigel) by murine B16 melanoma cells.
Invasion & metastasis 1997;17(2):82-93.
1997: Wakabayashi C; Hasegawa H; Murata J; Saiki I
In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration.
Oncology research 1997;9(8):411-7.
1997: Ohnishi Y; Sakamoto T; Fujii H; Kimura F; Murata J; Tazawa K; Fujimaki M; Sato Y; Kondo M; Une Y; Uchino J; Saiki I
Characterization of a liver metastatic variant of murine colon 26 carcinoma cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1997;18(2):113-22.
1996: Ohnishi Y; Fujii H; Kimura F; Mishima T; Murata J; Tazawa K; Fujimaki M; Okada F; Hosokawa M; Saiki I
Inhibitory effect of a traditional Chinese medicine, Juzen-taiho-to, on progressive growth of weakly malignant clone cells derived from murine fibrosarcoma.
Japanese journal of cancer research : Gann 1996;87(10):1039-44.
1996: Fujii H; Inobe M; Kimura F; Murata J; Murakami M; Onishi Y; Azuma I; Uede T; Saiki I
Vaccination of tumor cells transfected with the B7-1 (CD80) gene induces the anti-metastatic effect and tumor immunity in mice.
International journal of cancer. Journal international du cancer 1996;66(2):219-24.
1996: Saiki I; Koike C; Obata A; Fujii H; Murata J; Kiso M; Hasegawa A; Komazawa H; Tsukada H; Azuma I; Okada S; Oku N
Functional role of sialyl Lewis X and fibronectin-derived RGDS peptide analogue on tumor-cell arrest in lungs followed by extravasation.
International journal of cancer. Journal international du cancer 1996;65(6):833-9.
1996: Sato K; Yoo Y C; Matsuzawa K; Watanabe R; Saiki I; Tono-Oka S; Azuma I
Tolerance to the anti-metastatic effect of lipopolysaccharide against liver metastasis in mice.
International journal of cancer. Journal international du cancer 1996;66(1):98-103.
1996: Ata N; Oku T; Hattori M; Fujii H; Nakajima M; Saiki I
Inhibition by galloylglucose (GG6-10) of tumor invasion through extracellular matrix and gelatinase-mediated degradation of type IV collagens by metastatic tumor cells.
Oncology research 1996;8(12):503-11.
1996: Fujii H; Nishikawa N; Komazawa H; Orikasa A; Ono M; Itoh I; Murata J; Azuma I; Saiki I
Inhibition of tumor invasion and metastasis by peptidic mimetics of Arg-Gly Asp (RGD) derived from the cell recognition site of fibronectin.
Oncology research 1996;8(9):333-42.
1995: Fujii H; Komazawa H; Mori H; Kojima M; Itoh I; Murata J; Azuma I; Saiki I
Antimetastatic activities of synthetic Arg-Gly-Asp-Ser (RGDS) and Arg-Leu-Asp-Ser (RLDS) peptide analogues and their inhibitory mechanisms.
Biological & pharmaceutical bulletin 1995;18(12):1681-8.
1995: Mochizuki M; Yoo Y C; Matsuzawa K; Sato K; Saiki I; Tono-oka S; Samukawa K; Azuma I
Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng.
Biological & pharmaceutical bulletin 1995;18(9):1197-202.
1995: Sato K; Yoo Y C; Fukushima A; Saiki I; Takahashi T A; Fujihara M; Tono-Oka S; Azuma I
A novel synthetic lipid A analog with low endotoxicity, DT-5461, prevents lethal endotoxemia.
Infection and immunity 1995;63(8):2859-66.
1995: Sato K; Yoo Y C; Mochizuki M; Saiki I; Takahashi T A; Azuma I
Inhibition of tumor-induced angiogenesis by a synthetic lipid A analogue with low endotoxicity, DT-5461.
Japanese journal of cancer research : Gann 1995;86(4):374-82.
1995: Yoneda J; Saiki I; Igarashi Y; Kobayashi H; Fujii H; Ishizaki Y; Kimizuka F; Kato I; Azuma I
Role of the heparin-binding domain of chimeric peptides derived from fibronectin in cell spreading and motility.
Experimental cell research 1995;217(1):169-79.
1995: Komazawa H; Fujii H; Kojima M; Mori H; Ono M; Itoh I; Azuma I; Saiki I
Combination of anti-cell adhesive synthetic Arg-Gly-Asp-Ser analogue and anticancer drug doxorubicin heightens their original antimetastatic activities.
Oncology research 1995;7(7-8):341-51.
1994: Yoneda J; Saiki I; Kobayashi H; Fujii H; Ishizaki Y; Kato I; Kiso M; Hasegawa A; Azuma I
Inhibitory effect of recombinant fibronectin polypeptides on the adhesion of liver-metastatic lymphoma cells to hepatic sinusoidal endothelial cells and tumor invasion.
Japanese journal of cancer research : Gann 1994;85(7):723-34.
1994: Sato K; Mochizuki M; Saiki I; Yoo Y C; Samukawa K; Azuma I
Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2.
Biological & pharmaceutical bulletin 1994;17(5):635-9.
1994: Saiki I; Murata J; Yoneda J; Kobayashi H; Azuma I
Influence of fibroblasts on the invasion and migration of highly or weakly metastatic B16 melanoma cells.
International journal of cancer. Journal international du cancer 1994;56(6):867-73.
1994: Yoo Y C; Saiki I; Sato K; Azuma I
MDP-Lys(L18), a lipophilic derivative of muramyl dipeptide, inhibits the metastasis of haematogenous and non-haematogenous tumours in mice.
Vaccine 1994;12(2):175-60.
1994: Azuma I; Saiki I
Prevention of cancer metastasis in mice with fibronectin-related substances.
Princess Takamatsu symposia 1994;24():125-41.
1993: Komazawa H; Saiki I; Nishikawa N; Yoneda J; Yoo Y C; Kojima M; Ono M; Itoh I; Nishi N; Tokura S
Inhibition of tumor metastasis by Arg-Gly-Asp-Ser (RGDS) peptide conjugated with sulfated chitin derivative, SCM-chitin-RGDS.
Clinical & experimental metastasis 1993;11(6):482-91.
1993: Komazawa H; Saiki I; Aoki M; Kitaguchi H; Satoh H; Kojima M; Ono M; Itoh I; Azuma I
Synthetic Arg-Gly-Asp-Ser analogues of the cell recognition site of fibronectin that retain antimetastatic and anti-cell adhesive properties.
Biological & pharmaceutical bulletin 1993;16(10):997-1003.
1993: Saiki I; Yoneda J; Igarashi Y; Aoki M; Kusunose N; Ono K; Azuma I
Antimetastatic activity of polymeric RGDT peptides conjugated with poly(ethylene glycol).
Japanese journal of cancer research : Gann 1993;84(5):558-65.
1993: Saiki I; Fujii H; Yoneda J; Abe F; Nakajima M; Tsuruo T; Azuma I
Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation.
International journal of cancer. Journal international du cancer 1993;54(1):137-43.
1993: Saiki I; Yoneda J; Kobayashi H; Igarashi Y; Komazawa H; Ishizaki Y; Kato I; Azuma I
Antimetastatic effect by anti-adhesion therapy with cell-adhesive peptide of fibronectin in combination with anticancer drugs.
Japanese journal of cancer research : Gann 1993;84(3):326-35.
1992: Murata J; Saiki I; Yoneda J; Azuma I
Differences in chemotaxis to fibronectin in weakly and highly metastatic tumor cells.
Japanese journal of cancer research : Gann 1992;83(12):1327-33.
1992: Sato K; Saiki I; Yoo Y C; Igarashi Y; Kiso M; Hasegawa A; Azuma I
DT-5461, a new synthetic lipid A analogue, inhibits lung and liver metastasis of tumor in mice.
Japanese journal of cancer research : Gann 1992;83(10):1081-7.
1992: Saiki I; Sato K; Yoo Y C; Murata J; Yoneda J; Kiso M; Hasegawa A; Azuma I
Inhibition of tumor-induced angiogenesis by the administration of recombinant interferon-gamma followed by a synthetic lipid-A subunit analogue (GLA-60).
International journal of cancer. Journal international du cancer 1992;51(4):641-5.
1992: Yoneda J; Saiki I; Fujii H; Abe F; Kojima Y; Azuma I
Inhibition of tumor invasion and extracellular matrix degradation by ubenimex (bestatin).
Clinical & experimental metastasis 1992;10(1):49-59.
1992: Yoo Y C; Saiki I; Sato K; Azuma I
B30-MDP, a synthetic muramyl dipeptide derivative for tumour vaccination to enhance antitumour immunity and antimetastatic effect in mice.
Vaccine 1992;10(11):792-7.
1991: Saiki I; Naito S; Yoneda J; Azuma I; Price J E; Fidler I J
Characterization of the invasive and metastatic phenotype in human renal cell carcinoma.
Clinical & experimental metastasis 1991;9(6):551-66.
1991: Matsumoto Y; Saiki I; Makabe T; Yoneda J; Murata J; Kimizuka F; Ishizaki Y; Kato I; Azuma I
Inhibitory effect of antimetastatic fusion polypeptide of human fibronectin on tumor cell adhesion to extracellular matrices.
Japanese journal of cancer research : Gann 1991;82(10):1130-8.
1991: Saiki I; Matsumoto Y; Murata J; Makabe T; Yoneda J; Okuyama H; Kimizuka F; Ishizaki Y; Kato I; Azuma I
Recombinant fusion polypeptide with cell- and heparin-binding domains of fibronectin inhibits liver metastasis of L5178Y-ML25 lymphoma cells.
Japanese journal of cancer research : Gann 1991;82(10):1120-9.
1991: Saiki I; Makabe T; Yoneda J; Murata J; Ishizaki Y; Kimizuka F; Kato I; Azuma I
Inhibitory effect of fibronectin and its recombinant polypeptides on the adhesion of metastatic melanoma cells to laminin.
Japanese journal of cancer research : Gann 1991;82(10):1112-9.
1991: Matsumoto Y; Saiki I; Murata J; Okuyama H; Tamura M; Azuma I
Recombinant human granulocyte colony-stimulating factor inhibits the metastasis of hematogenous and non-hematogenous tumors in mice.
International journal of cancer. Journal international du cancer 1991;49(3):444-9.
1991: Murata J; Saiki I; Makabe T; Tsuta Y; Tokura S; Azuma I
Inhibition of tumor-induced angiogenesis by sulfated chitin derivatives.
Cancer research 1991;51(1):22-6.
1990: Saiki I; Murata J; Makabe T; Matsumoto Y; Ohdate Y; Kawase Y; Taguchi Y; Shimojo T; Kimizuka F; Kato I
Inhibition of lung metastasis by synthetic and recombinant fragments of human fibronectin with functional domains.
Japanese journal of cancer research : Gann 1990;81(10):1003-11.
1990: Makabe T; Saiki I; Murata J; Ohdate Y; Kawase Y; Taguchi Y; Shimojo T; Kimizuka F; Kato I; Azuma I
Modulation of haptotactic migration of metastatic melanoma cells by the interaction between heparin and heparin-binding domain of fibronectin.
The Journal of biological chemistry 1990;265(24):14270-6.
1990: Maeda H; Saiki I; Yamamoto N; Takahashi T; Sekiguchi S; Kiso M; Hasegawa A; Azuma I
Activation by synthetic lipid A subunit analogues (GLA compounds) of tumoricidal properties in human blood monocytes.
Vaccine 1990;8(3):237-42.
1990: Saiki I; Murata J; Nakajima M; Tokura S; Azuma I
Inhibition by sulfated chitin derivatives of invasion through extracellular matrix and enzymatic degradation by metastatic melanoma cells.
Cancer research 1990;50(12):3631-7.
1990: Saiki I; Murata J; Matsuno K; Ogawa R; Nishi N; Tokura S; Azuma I
Anti-metastatic and anti-invasive effects of polymeric Arg-Gly-Asp (RGD) peptide, poly(RGD), and its analogues.
Japanese journal of cancer research : Gann 1990;81(6-7):660-7.
1990: Saiki I; Murata J; Makabe T; Nishi N; Tokura S; Azuma I
Inhibition of tumor angiogenesis by a synthetic cell-adhesive polypeptide containing the Arg-Gly-Asp (RGD) sequence of fibronectin, poly(RGD).
Japanese journal of cancer research : Gann 1990;81(6-7):668-75.
1990: Murata J; Saiki I; Matsuno K; Tokura S; Azuma I
Inhibition of tumor cell arrest in lungs by antimetastatic chitin heparinoid.
Japanese journal of cancer research : Gann 1990;81(5):506-13.
1990: Watanabe K; Saiki I; Uraki Y; Tokura S; Azuma I
6-O-carboxymethyl-chitin (CM-chitin) as a drug carrier.
Chemical & pharmaceutical bulletin 1990;38(2):506-9.
1990: Saiki I; Maeda H; Murata J; Takahashi T; Sekiguchi S; Kiso M; Hasegawa A; Azuma I
Production of interleukin 1 from human monocytes stimulated by synthetic lipid A subunit analogues.
International journal of immunopharmacology 1990;12(3):297-305.
1989: Saiki I; Murata J; Iida J; Sakurai T; Nishi N; Matsuno K; Azuma I
Antimetastatic effects of synthetic polypeptides containing repeated structures of the cell adhesive Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) sequences.
British journal of cancer 1989;60(5):722-8.
1989: Saiki I; Murata J; Watanabe K; Fujii H; Abe F; Azuma I
Inhibition of tumor cell invasion by ubenimex (bestatin) in vitro.
Japanese journal of cancer research : Gann 1989;80(9):873-8.
1989: Murata J; Saiki I; Nishimura S; Nishi N; Tokura S; Azuma I
Inhibitory effect of chitin heparinoids on the lung metastasis of B16-BL6 melanoma.
Japanese journal of cancer research : Gann 1989;80(9):866-72.
1989: Murata J; Saiki I; Iida J; Azuma I; Kawahara H; Nishi N; Tokura S
Inhibition of tumour cell adhesion by anti-metastatic polypeptide containing a repetitive Arg-Gly-Asp sequence.
International journal of biological macromolecules 1989;11(4):226-32.
1989: Saiki I; Iida J; Murata J; Ogawa R; Nishi N; Sugimura K; Tokura S; Azuma I
Inhibition of the metastasis of murine malignant melanoma by synthetic polymeric peptides containing core sequences of cell-adhesive molecules.
Cancer research 1989;49(14):3815-22.
1989: Sakurai T; Saiki I; Ishida H; Takeda K; Azuma I
Lethal toxicity and adjuvant activities of synthetic TDM and its related compounds in mice.
Vaccine 1989;7(3):269-74.
1989: Maeda H; Saiki I; Ishida H; Kiso M; Hasegawa A; Azuma I
Adjuvant activities of synthetic lipid A subunit analogues and its conjugates with muramyl dipeptide derivatives.
Vaccine 1989;7(3):275-81.
1989: Iida J; Saiki I; Ishihara C; Azuma I
Prophylactic activity against Sendai virus infection and macrophage activation with lipophilic derivatives of N-acetylglucosaminylmuramyl tri- or tetrapeptides.
Vaccine 1989;7(3):225-8.
1989: Iida J; Saiki I; Ishihara C; Azuma I
Protective activity of recombinant cytokines against Sendai virus and herpes simplex virus (HSV) infections in mice.
Vaccine 1989;7(3):229-33.
1989: Saiki I; Murata J; Iida J; Nishi N; Sugimura K; Azuma I
The inhibition of murine lung metastasis by synthetic polypeptides [poly(arg-gly-asp) and poly(tyr-ile-gly-ser-arg)] with a core sequence of cell adhesion molecules.
British journal of cancer 1989;59(2):194-7.
1989: Saiki I; Iida J; Azuma I; Nishi N; Matsuno K
Biological activities of synthetic polypeptides containing a repetitive core sequence (Arg-Gly-Asp) of cell adhesion molecules.
International journal of biological macromolecules 1989;11(1):23-5.
1989: Iida J; Nishi N; Saiki I; Mizukoshi N; Ishihara C; Tokura S; Azuma I
Macrophage activation and host augmentation against Sendai or herpes simplex virus (HSV) infections with synthetic polypeptides in mice.
International journal of immunopharmacology 1989;11(3):249-58.
1989: Saiki I; Murata J; Saito S; Higashi N; Azuma I
Effect of systemic administration of mouse recombinant interferon-gamma on the lung tumor metastases in mice.
Molecular biotherapy 1989;1(5):261-7.
1989: Saiki I; Maeda H; Murata J; Yamamoto N; Kiso M; Hasegawa A; Azuma I
Antimetastatic effect of endogenous tumor necrosis factor induced by the treatment of recombinant interferon gamma followed by an analogue (GLA-60) to synthetic lipid A subunit.
Cancer immunology, immunotherapy : CII 1989;30(3):151-7.
1989: Saiki I; Maeda H; Sakurai T; Murata J; Iida J; Kiso M; Hasegawa A; Azuma I
Induction of an endogenous tumor necrosis factor in mice by murine recombinant interferon-gamma combined with a lipid A subunit analog (GLA-60) of low toxicity.
Cancer immunology, immunotherapy : CII 1989;29(2):101-8.
1988: Ishida H; Saiki I; Saito S; Hasegawa A; Kiso M; Azuma I
Regression of line-10 hepatocellular carcinoma by a less toxic cord factor analogue combined with L18-MDP or synthetic lipid A analogues.
Vaccine 1988;6(5):440-4.
1988: Azuma I; Saiki I; Iida J; Fukuda T; Kobayashi S
Immunological activities of multiprenylacetyl derivatives of muramyldipeptides.
Vaccine 1988;6(4):339-42.
1988: Saiki I; Saito S; Fujita C; Ishida H; Iida J; Murata J; Hasegawa A; Azuma I
Induction of tumoricidal macrophages and production of cytokines by synthetic muramyl dipeptide analogues.
Vaccine 1988;6(3):238-44.

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