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Nigel Birdsall

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Tatiana A Nenasheva; Marianne Neary; Nigel J M Birdsall; Ross A Breckenridge; Gregory I Mashanov; Justin E Molloy
Abundance, distribution, mobility and oligomeric state of M₂ muscarinic acetylcholine receptors in live cardiac muscle.
Daniel C-H Lin; Jian Luo; Kathy Nguyen; Nigel J M Birdsall; Sean P Brown; Michael Chen; Paul J Dransfield; Qi Guo; Jonathan Houze; Xian Yun Jiao; Thanh Tran; Marc Vimolratana; Yingcai Wang; Jane Zhang; Gayathri Swaminath
Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor.
Nigel J M Birdsall
Class A GPCR heterodimers: evidence from binding studies.

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All Publications

2013: Tatiana A Nenasheva; Marianne Neary; Nigel J M Birdsall; Ross A Breckenridge; Gregory I Mashanov; Justin E Molloy
Abundance, distribution, mobility and oligomeric state of M₂ muscarinic acetylcholine receptors in live cardiac muscle.
Journal of molecular and cellular cardiology 2013;57():129-36.
2012: Daniel C-H Lin; Jian Luo; Kathy Nguyen; Nigel J M Birdsall; Sean P Brown; Michael Chen; Paul J Dransfield; Qi Guo; Jonathan Houze; Xian Yun Jiao; Thanh Tran; Marc Vimolratana; Yingcai Wang; Jane Zhang; Gayathri Swaminath
Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor.
Molecular pharmacology 2012;82(5):843-59.
2010: Nigel J M Birdsall
Class A GPCR heterodimers: evidence from binding studies.
Trends in pharmacological sciences 2010;31(11):499-508.
2010: Neil Benson; Nelleke Snelder; Bart Ploeger; Carolyn Napier; Harriet Sale; Nigel J M Birdsall; Richard P Butt; Piet H van Der Graaf
Estimation of binding rate constants using a simultaneous mixed-effects method: application to monoamine transporter reuptake inhibitor reboxetine.
British journal of pharmacology 2010;160(2):389-98.
2010: Jonathan A Hern; Asma H Baig; Gregory I Mashanov; Berry Birdsall; John E T Corrie; Sebastian Lazareno; Justin E Molloy; Nigel J M Birdsall
Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2693-8.
2008: Carole Fruchart-Gaillard; Gilles Mourier; Catherine Marquer; Enrico A Stura; Nigel J M Birdsall; Denis Servent
Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and N-methylscopolamine-occupied states.
Molecular pharmacology 2008;74(6):1554-63.
2006: Anders A Jensen; Parviz Gharagozloo; Nigel J M Birdsall; Darius P Zlotos
Pharmacological characterisation of strychnine and brucine analogues at glycine and alpha7 nicotinic acetylcholine receptors.
European journal of pharmacology 2006;539(1-2):27-33.
2005: Christian Tränkle; Andreas Dittmann; Uwe Schulz; Oliver Weyand; Stefan Buller; Kirstin Jöhren; Eberhard Heller; Nigel J M Birdsall; Ulrike Holzgrabe; John Ellis; Hans-Dieter Höltje; Klaus Mohr
Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors.
Molecular pharmacology 2005;68(6):1597-610.
2005: Nigel J M Birdsall; Sebastian Lazareno
Allosterism at muscarinic receptors: ligands and mechanisms.
Mini reviews in medicinal chemistry 2005;5(6):523-43.
2004: Sebastian Lazareno; V Dolezal; Angela Popham; Nigel J M Birdsall
Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity.
Molecular pharmacology 2004;65(1):257-66.
2003: Christian Tränkle; Oliver Weyand; Uta Voigtländer; Anita Mynett; Sebastian Lazareno; Nigel J M Birdsall; Klaus Mohr
Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.
Molecular pharmacology 2003;64(1):180-90.
2003: Sebastian Lazareno; Angela Popham; Nigel J M Birdsall
Progress toward a high-affinity allosteric enhancer at muscarinic M1 receptors.
Journal of molecular neuroscience : MN 2003;20(3):363-7.
2002: Sebastian Lazareno; Angela Popham; Nigel J M Birdsall
Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors.
Molecular pharmacology 2002;62(6):1492-505.
2002: Sebastian Lazareno; Angela Popham; Nigel J M Birdsall
Towards a high-affinity allosteric enhancer at muscarinic M1 receptors.
Journal of molecular neuroscience : MN 2002;19(1-2):123-7.
2002: Parviz Gharagozloo; Sebastian Lazareno; Masao Miyauchi; Angela Popham; Nigel J M Birdsall
Substituted pentacyclic carbazolones as novel muscarinic allosteric agents: synthesis and structure-affinity and cooperativity relationships.
Journal of medicinal chemistry 2002;45(6):1259-74.
2001: Nigel J M Birdsall; Sebastian Lazareno; Angela Popham; José W Saldanha
Multiple allosteric sites on muscarinic receptors.
Life sciences 2001;68(22-23):2517-24.
2000: RA Leppik; Nigel J M Birdsall
Agonist binding and function at the human alpha(2A)-adrenoceptor: allosteric modulation by amilorides.
Molecular pharmacology 2000;58(5):1091-9.
2000: Sebastian Lazareno; Angela Popham; Nigel J M Birdsall
Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site.
Molecular pharmacology 2000;58(1):194-207.
2000: RA Leppik; Anita Mynett; Sebastian Lazareno; Nigel J M Birdsall
Allosteric interactions between the antagonist prazosin and amiloride analogs at the human alpha(1A)-adrenergic receptor.
Molecular pharmacology 2000;57(3):436-45.
2000: Sebastian Lazareno; Nigel J M Birdsall
Effects of contamination on radioligand binding parameters.
Trends in pharmacological sciences 2000;21(2):57-60.
1999: Nigel J M Birdsall; T Farries; Parviz Gharagozloo; S Kobayashi; Sebastian Lazareno; M Sugimoto
Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies.
Molecular pharmacology 1999;55(4):778-86.
1999: Parviz Gharagozloo; Sebastian Lazareno; Angela Popham; Nigel J M Birdsall
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
Journal of medicinal chemistry 1999;42(3):438-45.
1999: Sebastian Lazareno; B Birdsall; T Fukazawa; Parviz Gharagozloo; T Hashimoto; H Kuwano; Angela Popham; M Sugimoto; Nigel J M Birdsall
Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors.
Life sciences 1999;64(6-7):519-26.
1998: Sebastian Lazareno; Angela Popham; Nigel J M Birdsall
Muscarinic interactions of bisindolylmaleimide analogues.
European journal of pharmacology 1998;360(2-3):281-4.
1998: RA Leppik; Sebastian Lazareno; Anita Mynett; Nigel J M Birdsall
Characterization of the allosteric interactions between antagonists and amiloride analogues at the human alpha2A-adrenergic receptor.
Molecular pharmacology 1998;53(5):916-25.
1998: Sebastian Lazareno; Parviz Gharagozloo; D Kuonen; Angela Popham; Nigel J M Birdsall
Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies.
Molecular pharmacology 1998;53(3):573-89.
1997: Nigel J M Birdsall; Sebastian Lazareno
To what extent can binding studies allow the quantification of affinity and efficacy?
Annals of the New York Academy of Sciences 1997;812():41-7.
1997: Nigel J M Birdsall; T Farries; Parviz Gharagozloo; S Kobayashi; D Kuonen; Sebastian Lazareno; Angela Popham; M Sugimoto
Selective allosteric enhancement of the binding and actions of acetylcholine at muscarinic receptor subtypes.
Life sciences 1997;60(13-14):1047-52.
1996: F R Cohen; Sebastian Lazareno; Nigel J M Birdsall
The affinity of adenosine for the high- and low-affinity states of the human adenosine A1 receptor.
European journal of pharmacology 1996;309(1):111-4.
1996: F R Cohen; Sebastian Lazareno; Nigel J M Birdsall
The effects of saponin on the binding and functional properties of the human adenosine A1 receptor.
British journal of pharmacology 1996;117(7):1521-9.
1996: Nigel J M Birdsall; Sebastian Lazareno; H Matsui
Allosteric regulation of muscarinic receptors.
Progress in brain research 1996;109():147-51.
1995: Sebastian Lazareno; Nigel J M Birdsall
Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.
Molecular pharmacology 1995;48(2):362-78.
1995: Nigel J M Birdsall; F Cohen; Sebastian Lazareno; H Matsui
Allosteric regulation of G-protein-linked receptors.
Biochemical Society transactions 1995;23(1):108-11.
1995: H Matsui; Sebastian Lazareno; Nigel J M Birdsall
Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis.
Molecular pharmacology 1995;47(1):88-98.
1994: T A Spalding; Nigel J M Birdsall; CA Curtis; Edward C Hulme
Acetylcholine mustard labels the binding site aspartate in muscarinic acetylcholine receptors.
The Journal of biological chemistry 1994;269(6):4092-7.
1993: Sebastian Lazareno; Nigel J M Birdsall
Pharmacological characterization of acetylcholine-stimulated [35S]-GTP gamma S binding mediated by human muscarinic m1-m4 receptors: antagonist studies.
British journal of pharmacology 1993;109(4):1120-7.
1993: Sebastian Lazareno; Nigel J M Birdsall
Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng-Prusoff equations.
British journal of pharmacology 1993;109(4):1110-9.
1993: Sebastian Lazareno; Nigel J M Birdsall
Estimation of antagonist Kb from inhibition curves in functional experiments: alternatives to the Cheng-Prusoff equation.
Trends in pharmacological sciences 1993;14(6):237-9.
1993: Sebastian Lazareno; T Farries; Nigel J M Birdsall
Pharmacological characterization of guanine nucleotide exchange reactions in membranes from CHO cells stably transfected with human muscarinic receptors m1-m4.
Life sciences 1993;52(5-6):449-56.
1991: Nigel J M Birdsall
Wheel on the sweet smell of success.
Trends in pharmacological sciences 1991;12(8):283-5.
1991: E K Pedder; P Eveleigh; D Poyner; Edward C Hulme; Nigel J M Birdsall
Modulation of the structure-binding relationships of antagonists for muscarinic acetylcholine receptor subtypes.
British journal of pharmacology 1991;103(2):1561-7.
1991: Nigel J M Birdsall
Cloning and structure-function of the H2 histamine receptor.
Trends in pharmacological sciences 1991;12(1):9-10.
1990: N J Buckley; Edward C Hulme; Nigel J M Birdsall
Use of clonal cell lines in the analysis of neurotransmitter receptor mechanisms and function.
Biochimica et biophysica acta 1990;1055(1):43-53.
1990: Edward C Hulme; T A Spalding; CA Curtis; Nigel J M Birdsall; J E Corrie
Blockade of muscarinic receptors by alkylating agonist analogues.
Biochemical Society transactions 1990;18(3):440-1.
1990: Edward C Hulme; Nigel J M Birdsall; N J Buckley
Muscarinic receptor subtypes.
Annual review of pharmacology and toxicology 1990;30():633-73.
1989: Nigel J M Birdsall; S C Chan; P Eveleigh; E C Hulme; K W Miller
The modes of binding of ligands to cardiac muscarinic receptors.
Trends in pharmacological sciences 1989;Suppl():31-4.
1989: D R Poyner; Nigel J M Birdsall; C Curtis; P Eveleigh; Edward C Hulme; E K Pedder; M Wheatley
Binding and hydrodynamic properties of muscarinic receptor subtypes solubilized in 3-(3-cholamidopropyl)dimethylammonio-2-hydroxy-1-propanesulfonate.
Molecular pharmacology 1989;36(3):420-9.
1989: P Eveleigh; Edward C Hulme; C Schudt; Nigel J M Birdsall
The existence of stable enantiomers of telenzepine and their stereoselective interaction with muscarinic receptor subtypes.
Molecular pharmacology 1989;35(4):477-83.
1989: CA Curtis; M Wheatley; S Bansal; Nigel J M Birdsall; P Eveleigh; E K Pedder; D Poyner; Edward C Hulme
Propylbenzilylcholine mustard labels an acidic residue in transmembrane helix 3 of the muscarinic receptor.
The Journal of biological chemistry 1989;264(1):489-95.
1988: M Wheatley; E C Hulme; Nigel J M Birdsall; CA Curtis; P Eveleigh; E K Pedder; D Poyner
Peptide mapping studies on muscarinic receptors: receptor structure and location of the ligand binding site.
Trends in pharmacological sciences 1988;Suppl():19-24.
1988: Nigel J M Birdsall; CA Curtis; P Eveleigh; Edward C Hulme; E K Pedder; D Poyner; M Wheatley
Muscarinic receptor subtypes and the selectivity of agonists and antagonists.
Pharmacology 1988;37 Suppl 1():22-31.
1987: M Wheatley; Nigel J M Birdsall; C Curtis; P Eveleigh; E K Pedder; D Poyner; J M Stockton; Edward C Hulme
The structure and properties of the purified muscarinic acetylcholine receptor from rat forebrain.
Biochemical Society transactions 1987;15(1):113-6.
1987: Edward C Hulme; Nigel J M Birdsall; M Wheatley; C Curtis; E K Pedder; D Poyner; J M Stockton; P Eveleigh
Muscarinic acetylcholine receptors: structure, function subtypes and therapeutic perspectives.
Postgraduate medical journal 1987;63 Suppl 1():5-12.
1986: Nigel J M Birdsall; E C Hulme; M Keen
The binding of pirenzepine to digitonin-solubilized muscarinic acetylcholine receptors from the rat myocardium.
British journal of pharmacology 1986;87(2):307-16.
1986: Nigel J M Birdsall; Edward C Hulme; M Keen; E K Pedder; D Poyner; J M Stockton; M Wheatley
Soluble and membrane-bound muscarinic acetylcholine receptors.
Biochemical Society symposium 1986;52():23-32.
1985: Christopher P Berrie; Nigel J M Birdsall; H K Dadi; Edward C Hulme; R J Morris; J M Stockton; M Wheatley
Purification of the muscarinic acetylcholine receptor from rat forebrain.
Biochemical Society transactions 1985;13(6):1101-3.
1985: Christopher P Berrie; Nigel J M Birdsall; Edward C Hulme; M Keen; J M Stockton
Solubilization and characterization of high and low affinity pirenzepine binding sites from rat cerebral cortex.
British journal of pharmacology 1985;85(3):697-703.
1984: Christopher P Berrie; Nigel J M Birdsall; Edward C Hulme; M Keen; J M Stockton
Solubilization and characterization of guanine nucleotide-sensitive muscarinic agonist binding sites from rat myocardium.
British journal of pharmacology 1984;82(4):853-61.
1984: Christopher P Berrie; Nigel J M Birdsall; K Haga; T Haga; Edward C Hulme
Hydrodynamic properties of muscarinic acetylcholine receptors solubilized from rat forebrain.
British journal of pharmacology 1984;82(4):839-51.
1983: Edward C Hulme; Christopher P Berrie; Nigel J M Birdsall; M Jameson; J M Stockton
Regulation of muscarinic agonist binding by cations and guanine nucleotides.
European journal of pharmacology 1983;94(1-2):59-72.
1983: Nigel J M Birdsall; A S Burgen; Edward C Hulme; E H Wong
The effect of p-chloromercuribenzoate on structure-binding relationships of muscarinic receptors in the rat cerebral cortex.
British journal of pharmacology 1983;80(1):197-204.
1983: Nigel J M Birdsall; A S Burgen; Edward C Hulme; E H Wong
The effects of p-chloromercuribenzoate on muscarinic receptors in the cerebral cortex.
British journal of pharmacology 1983;80(1):187-96.
1983: J M Stockton; Nigel J M Birdsall; A S Burgen; Edward C Hulme
Modification of the binding properties of muscarinic receptors by gallamine.
Molecular pharmacology 1983;23(3):551-7.
1983: Nigel J M Birdsall; A S Burgen; Edward C Hulme; J M Stockton; Michael Zigmond
The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart.
British journal of pharmacology 1983;78(2):257-9.
1983: Edward C Hulme; Christopher P Berrie; T Haga; Nigel J M Birdsall; A S Burgen; J Stockton
Solubilisation and molecular characterisation of muscarinic acetylcholine receptors.
Journal of receptor research 1983;3(1-2):301-11.
1983: Nigel J M Birdsall; Edward C Hulme; J Stockton; A S Burgen; Christopher P Berrie; R Hammer; E H Wong; Michael Zigmond
Muscarinic receptor subclasses: evidence from binding studies.
Advances in biochemical psychopharmacology 1983;37():323-9.
1983: Nigel J M Birdsall; E C Hulme; J M Stockton
Muscarinic receptor subclasses: allosteric interactions.
Cold Spring Harbor symposia on quantitative biology 1983;48 Pt 1():53-6.
1982: E Bárány; Christopher P Berrie; Nigel J M Birdsall; A S Burgen; Edward C Hulme
The binding properties of the muscarinic receptors of the cynomolgus monkey ciliary body and the response to the induction of agonist subsensitivity.
British journal of pharmacology 1982;77(4):731-9.
1982: J Nargeot; H A Lester; Nigel J M Birdsall; J Stockton; N H Wassermann; Bernard F Erlanger
A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart.
The Journal of general physiology 1982;79(4):657-78.
1982: J Stockton; Nigel J M Birdsall; A S Burgen; Edward C Hulme
The theory, methods and relevance of muscarinic receptor binding studies.
Scandinavian journal of gastroenterology. Supplement 1982;72():43-7.
1982: K F Sewing; W Londong; Reinhold W Stockbrügger; B H Jaup; J Stockton; Nigel J M Birdsall; R Hammer; G Koelle; B W Heathcote; G Dotevall
Classification of antimuscarinic substances. Round table discussion.
Scandinavian journal of gastroenterology. Supplement 1982;72():265-73.
1981: J Coutinho-Netto; M Boyar; H F Bradford; Nigel J M Birdsall; Edward C Hulme
Acetylcholine release and muscarinic receptors in cortical synaptosomes from epileptic rats.
Experimental neurology 1981;74(3):837-46.
1981: A S Abdul-Ghani; M M Boyar; J Coutinho-Netto; H F Bradford; Christopher P Berrie; Edward C Hulme; Nigel J M Birdsall
Effect of tityus toxin and sensory stimulation on muscarinic cholinergic receptors in vivo.
Biochemical pharmacology 1981;30(19):2713-4.
1981: Edward C Hulme; Christopher P Berrie; Nigel J M Birdsall; A S Burgen
Two populations of binding sites for muscarinic antagonists in the rat heart.
European journal of pharmacology 1981;73(2-3):137-42.
1980: J W Wells; Nigel J M Birdsall; A S Burgen; Edward C Hulme
Competitive binding studies with multiple sites. Effects arising from depletion of the free radioligand.
Biochimica et biophysica acta 1980;632(3):464-9.
1980: Michael J Kuhar; Nigel J M Birdsall; A S Burgen; Edward C Hulme
Ontogeny of muscarinic receptors in rat brain.
Brain research 1980;184(2):375-83.
1980: Nigel J M Birdsall; A S Burgen; Edward C Hulme
The binding properties of muscarinic receptors in the brain of the frog (R. temporaria).
Brain research 1980;184(2):385-93.
1980: Nigel J M Birdsall; E C Hulme; A Burgen
The character of the muscarinic receptors in different regions of the rat brain.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1980;207(1166):1-12.
1980: R Hammer; Christopher P Berrie; Nigel J M Birdsall; A S Burgen; Edward C Hulme
Pirenzepine distinguishes between different subclasses of muscarinic receptors.
Nature 1980;283(5742):90-2.
1980: Nigel J M Birdsall; A S Burgen; Edward C Hulme; E H Wong
Effects of p-chloromercuribenzoate on muscarinic receptor binding in rat brain [proceedings].
British journal of pharmacology 1980;68(1):142P-143P.
1980: Nigel J M Birdsall; A S Burgen; R Hammer; Edward C Hulme; J Stockton
Pirenzepine--a ligand with original binding properties to muscarinic receptors.
Scandinavian journal of gastroenterology. Supplement 1980;66():1-4.
1980: Nigel J M Birdsall; Christopher P Berrie; A S Burgen; Edward C Hulme
Modulation of the binding properties of muscarinic receptors: evidence for receptor-effector coupling.
Advances in biochemical psychopharmacology 1980;21():107-16.