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Rosa Sainz

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Isabel Quiros-Gonzalez; Rosa M Sainz; David Hevia; Juan Mayo
MnSOD drives neuroendocrine differentiation, androgen independence, and cell survival in prostate cancer cells.
Dun-Xian Tan; Rüdiger Hardeland; Lucien C Manchester; Sergio D Paredes; Ahmet Korkmaz; Rosa M Sainz; Juan Mayo; Lorena Fuentes; Russel J Reiter
The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness.
David Hevia; Juan Mayo; I Quiros; C Gomez-Cordoves; Rosa M Sainz
Monitoring intracellular melatonin levels in human prostate normal and cancer cells by HPLC.

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All Publications

2011: Isabel Quiros-Gonzalez; Rosa M Sainz; David Hevia; Juan Mayo
MnSOD drives neuroendocrine differentiation, androgen independence, and cell survival in prostate cancer cells.
Free radical biology & medicine 2011;50(4):525-36.
2010: Dun-Xian Tan; Rüdiger Hardeland; Lucien C Manchester; Sergio D Paredes; Ahmet Korkmaz; Rosa M Sainz; Juan Mayo; Lorena Fuentes; Russel J Reiter
The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness.
Biological reviews of the Cambridge Philosophical Society 2010;85(3):607-23.
2010: David Hevia; Juan Mayo; I Quiros; C Gomez-Cordoves; Rosa M Sainz
Monitoring intracellular melatonin levels in human prostate normal and cancer cells by HPLC.
Analytical and bioanalytical chemistry 2010;397(3):1235-44.
2010: David Hevia; C Botas; Rosa M Sainz; I Quiros; D Blanco; Dun-Xian Tan; C Gomez-Cordoves; Juan Mayo
Development and validation of new methods for the determination of melatonin and its oxidative metabolites by high performance liquid chromatography and capillary electrophoresis, using multivariate optimization.
Journal of chromatography. A 2010;1217(8):1368-74.
2009: Russel J Reiter; Dun-Xian Tan; Lucien C Manchester; Sergio D Paredes; Juan Mayo; Rosa M Sainz
Melatonin and reproduction revisited.
Biology of reproduction 2009;81(3):445-56.
2008: Rosa M Sainz; Russel J Reiter; Dun-Xian Tan; Francis Roldan; Mohan Natarajan; Isabel Quiros; David Hevia; Carmen Rodriguez; Juan Mayo
Critical role of glutathione in melatonin enhancement of tumor necrosis factor and ionizing radiation-induced apoptosis in prostate cancer cells in vitro.
Journal of pineal research 2008;45(3):258-70.
2008: David Hevia; Rosa M Sainz; Domingo Blanco; Isabel Quirós; Dun-Xian Tan; Carmen Rodríguez; Juan Mayo
Melatonin uptake in prostate cancer cells: intracellular transport versus simple passive diffusion.
Journal of pineal research 2008;45(3):247-57.
2008: Isabel Quiros; Juan Mayo; O Garcia-Suarez; David Hevia; Vanesa Martin; Carmen Rodríguez; Rosa M Sainz
Melatonin prevents glucocorticoid inhibition of cell proliferation and toxicity in hippocampal cells by reducing glucocorticoid receptor nuclear translocation.
The Journal of steroid biochemistry and molecular biology 2008;110(1-2):116-24.
2007: M P Carrera; Isaac Antolín; Vanesa Martín; Rosa M Sainz; Juan Mayo; Federico Herrera; Guillermo García-Santos; Carmen Rodríguez
Antioxidants do not prevent acrylonitrile-induced toxicity.
Toxicology letters 2007;169(3):236-44.
2005: Dun-Xian Tan; Lucien C Manchester; Rosa M Sainz; Juan Mayo; Josefa Leon-Lopez; Rüdiger Hardeland; Burkhard Poeggeler; Russel J Reiter
Interactions between melatonin and nicotinamide nucleotide: NADH preservation in cells and in cell-free systems by melatonin.
Journal of pineal research 2005;39(2):185-94.
2005: Juan Mayo; Rosa M Sainz; Dun-Xian Tan; Rüdiger Hardeland; Josefa Leon; Carmen Rodriguez; Russel J Reiter
Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages.
Journal of neuroimmunology 2005;165(1-2):139-49.
2005: Juan Mayo; Rosa M Sainz; Dun-Xian Tan; Isaac Antolín; Carmen Rodríguez; Russel J Reiter
Melatonin and Parkinson's disease.
Endocrine 2005;27(2):169-78.
2005: Dun-Xian Tan; Lucien C Manchester; Rosa M Sainz; Juan Mayo; Josefa León; Russel J Reiter
Physiological ischemia/reperfusion phenomena and their relation to endogenous melatonin production: a hypothesis.
Endocrine 2005;27(2):149-58.
2005: Rosa M Sainz; Juan Mayo; Dun-Xian Tan; Josefa León; Lucien C Manchester; Russel J Reiter
Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism.
The Prostate 2005;63(1):29-43.
2004: Federico Herrera; Juan Mayo; Vanesa Martín; Rosa M Sainz; Isaac Antolin; Carmen Rodriguez
Cytotoxicity and oncostatic activity of the thiazolidinedione derivative CGP 52608 on central nervous system cancer cells.
Cancer letters 2004;211(1):47-55.
2004: Josefa Leon-Lopez; Darío Acuña-Castroviejo; Rosa M Sainz; Juan Mayo; Dun-Xian Tan; Russel J Reiter
Melatonin and mitochondrial function.
Life sciences 2004;75(7):765-90.
2004: Russel J Reiter; Dun-Xian Tan; Eloisa Gitto; Rosa M Sainz; Juan Mayo; Josefa Leon-Lopez; Lucien C Manchester; Ertugrul Kilic; Ulkan Kilic
Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage.
Polish journal of pharmacology 2004;56(2):159-70.
2004: Carmen Rodriguez; Juan Mayo; Rosa M Sainz; Isaac Antolín; Federico Herrera; Vanesa Martín; Russel J Reiter
Regulation of antioxidant enzymes: a significant role for melatonin.
Journal of pineal research 2004;36(1):1-9.
2003: Rosa M Sainz; Juan Mayo; Russel J Reiter; D X Tan; C Rodriguez
Apoptosis in primary lymphoid organs with aging.
Microscopy research and technique 2003;62(6):524-39.
2003: Russel J Reiter; D-X Tan; Juan Mayo; Rosa M Sainz; J Leon; D Bandyopadhyay
Neurally-mediated and neurally-independent beneficial actions of melatonin in the gastrointestinal tract.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2003;54 Suppl 4():113-25.
2003: Rosa M Sainz; Juan Mayo; C Rodriguez; Dun-Xian Tan; Silvia Lopez-Burillo; Russel J Reiter
Melatonin and cell death: differential actions on apoptosis in normal and cancer cells.
Cellular and molecular life sciences : CMLS 2003;60(7):1407-26.
2003: Russel J Reiter; Rosa M Sainz; Silvia Lopez-Burillo; Juan Mayo; Lucien C Manchester; Dun-Xian Tan
Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke.
Annals of the New York Academy of Sciences 2003;993():35-47; discussion 48-53.
2003: Juan Mayo; Dun-Xian Tan; Rosa M Sainz; Silvia Lopez-Burillo; Russel J Reiter
Oxidative damage to catalase induced by peroxyl radicals: functional protection by melatonin and other antioxidants.
Free radical research 2003;37(5):543-53.
2003: Silvia López-Burillo; Dun-Xian Tan; Juan Mayo; Rosa M Sainz; Lucien C Manchester; Russel J Reiter
Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions.
Journal of pineal research 2003;34(4):269-77.
2003: Dun-Xian Tan; Rüdiger Hardeland; Lucien C Manchester; Burkhard Poeggeler; Silvia Lopez-Burillo; Juan Mayo; Rosa M Sainz; Russel J Reiter
Mechanistic and comparative studies of melatonin and classic antioxidants in terms of their interactions with the ABTS cation radical.
Journal of pineal research 2003;34(4):249-59.
2003: Juan Mayo; Dun-Xian Tan; Rosa M Sainz; Mohan Natarajan; Silvia Lopez-Burillo; Russel J Reiter
Protection against oxidative protein damage induced by metal-catalyzed reaction or alkylperoxyl radicals: comparative effects of melatonin and other antioxidants.
Biochimica et biophysica acta 2003;1620(1-3):139-50.
2003: Rosa M Sainz; Juan Mayo; Dun-Xian Tan; Silvia Lopez-Burillo; Mohan Natarajan; Russel J Reiter
Antioxidant activity of melatonin in Chinese hamster ovarian cells: changes in cellular proliferation and differentiation.
Biochemical and biophysical research communications 2003;302(3):625-34.
2003: Vanesa Martín; Rosa M Sainz; Juan Mayo; Isaac Antolín; Federico Herrera; Carmen Rodríguez
Daily rhythm of gene expression in rat superoxide dismutases.
Endocrine research 2003;29(1):83-95.
2003: Russel J Reiter; Dun-Xian Tan; Lucien C Manchester; Silvia Lopez-Burillo; Rosa M Sainz; Juan Mayo
Melatonin: detoxification of oxygen and nitrogen-based toxic reactants.
Advances in experimental medicine and biology 2003;527():539-48.
2003: Russel J Reiter; Dun-Xian Tan; Juan Mayo; Rosa M Sainz; Josefa Leon-Lopez; Zbigniew Czarnocki
Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
Acta biochimica Polonica 2003;50(4):1129-46.
2003: Dun-Xian Tan; Lucien C Manchester; Rüdiger Hardeland; Silvia Lopez-Burillo; Juan Mayo; Rosa M Sainz; Russel J Reiter
Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin.
Journal of pineal research 2003;34(1):75-8.
2002: Russel J Reiter; Dun-Xian Tan; Juan Mayo; Rosa M Sainz; Silvia Lopez-Burillo
Melatonin, longevity and health in the aged: an assessment.
Free radical research 2002;36(12):1323-9.
2002: Vanesa Martín; Rosa M Sainz; Isaac Antolín; Juan Mayo; Federico Herrera; Carmen Rodríguez
Several antioxidant pathways are involved in astrocyte protection by melatonin.
Journal of pineal research 2002;33(4):204-12.
2002: Juan Mayo; Rosa M Sainz; I Antoli; Federico Herrera; Vanesa Martin; Carmen Rodriguez
Melatonin regulation of antioxidant enzyme gene expression.
Cellular and molecular life sciences : CMLS 2002;59(10):1706-13.
2002: Russel J Reiter; Dun-Xian Tan; Rosa M Sainz; Juan Mayo; Silvia Lopez-Burillo
Melatonin: reducing the toxicity and increasing the efficacy of drugs.
The Journal of pharmacy and pharmacology 2002;54(10):1299-321.
2002: Isaac Antolín; Juan Mayo; Rosa M Sainz; María de los Angeles del Brío; Federico Herrera; Vanesa Martín; Carmen Rodríguez
Protective effect of melatonin in a chronic experimental model of Parkinson's disease.
Brain research 2002;943(2):163-73.
2002: Dun-Xian Tan; Russel J Reiter; Lucien C Manchester; Mei-ting Yan; Mamdouh El-Sawi; Rosa M Sainz; Juan Mayo; Ron Kohen; Mario Allegra; Rüdiger Hardeland
Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger.
Current topics in medicinal chemistry 2002;2(2):181-97.
2002: Russel J Reiter; Dun-Xian Tan; Rosa M Sainz; Juan Mayo
Melatonin protects the heart against both ischemia/reperfusion injury and chemotherapeutic drugs.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2002;16(1):5-6.
2001: Federico Herrera; Rosa M Sainz; Juan Mayo; Vanesa Martín; Isaac Antolín; Carmen Rodriguez
Glutamate induces oxidative stress not mediated by glutamate receptors or cystine transporters: protective effect of melatonin and other antioxidants.
Journal of pineal research 2001;31(4):356-62.
2001: Dun-Xian Tan; Lucien C Manchester; Susanne Burkhardt; Rosa M Sainz; Juan Mayo; R Kohen; E Shohami; Y S Huo; Rüdiger Hardeland; Russel J Reiter
N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(12):2294-6.
2000: Rosa M Sainz; Russel J Reiter; Juan Mayo; J Cabrera; Dun-Xian Tan; Wenbo Qi; JJ Garcia
Changes in lipid peroxidation during pregnancy and after delivery in rats: effect of pinealectomy.
Journal of reproduction and fertility 2000;119(1):143-9.
2000: J Cabrera; Russel J Reiter; Dun-Xian Tan; Wenbo Qi; Rosa M Sainz; Juan Mayo; JJ Garcia; S J Kim; Gamal H El-Sokkary
Melatonin reduces oxidative neurotoxicity due to quinolinic acid: in vitro and in vivo findings.
Neuropharmacology 2000;39(3):507-14.
1999: Wenbo Qi; Dun-Xian Tan; Russel J Reiter; S J Kim; Lucien C Manchester; J Cabrera; Rosa M Sainz; Juan Mayo
Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats.
Digestive diseases and sciences 1999;44(11):2257-62.
1999: Dun-Xian Tan; Lucien C Manchester; Russel J Reiter; WB Qi; M Zhang; Susan Weintraub; J Cabrera; Rosa M Sainz; Juan Mayo
Identification of highly elevated levels of melatonin in bone marrow: its origin and significance.
Biochimica et biophysica acta 1999;1472(1-2):206-14.
1999: Rosa M Sainz; Juan Mayo; Russel J Reiter; Isaac Antolin; Manuel M Esteban; Carmen Rodriguez
Melatonin regulates glucocorticoid receptor: an answer to its antiapoptotic action in thymus.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(12):1547-56.
1999: Juan Mayo; Rosa M Sainz; Isaac Antolín; Carmen Rodriguez
Ultrastructural confirmation of neuronal protection by melatonin against the neurotoxin 6-hydroxydopamine cell damage.
Brain research 1999;818(2):221-7.
1999: Russel J Reiter; J Cabrera; Rosa M Sainz; Juan Mayo; Lucien C Manchester; Dun-Xian Tan
Melatonin as a pharmacological agent against neuronal loss in experimental models of Huntington's disease, Alzheimer's disease and parkinsonism.
Annals of the New York Academy of Sciences 1999;890():471-85.
1999: Russel J Reiter; Dun-Xian Tan; J Cabrera; D D'Arpa; Rosa M Sainz; Juan Mayo; S Ramos
The oxidant/antioxidant network: role of melatonin.
Biological signals and receptors 1999;8(1-2):56-63.
1998: Juan Mayo; Rosa M Sainz; H Uría; Isaac Antolín; M M Estéban
Inhibition of cell proliferation: a mechanism likely to mediate the prevention of neuronal cell death by melatonin.
Journal of pineal research 1998;25(1):12-8.
1998: Juan Mayo; Rosa M Sainz; H Uria; Isaac Antolin; Manuel M Esteban; Carmen Rodriguez
Melatonin prevents apoptosis induced by 6-hydroxydopamine in neuronal cells: implications for Parkinson's disease.
Journal of pineal research 1998;24(3):179-92.
1996: Carmen Rodriguez; M Kotler; I Antolin; Rosa M Sainz; A Menendez-Pelaez
Regulation of the aminolevulinate synthase gene in the Syrian hamster Harderian gland: changes during development and circadian rhythm and role of some hormones.
Microscopy research and technique 1996;34(1):65-70.
1995: Rosa M Sainz; Juan Mayo; H Uría; M Kotler; Isaac Antolín; Carmen Rodriguez; A Menendez-Pelaez
The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytes.
Journal of pineal research 1995;19(4):178-88.
1993: A Menendez-Pelaez; Rosa M Sainz; Juan Mayo; M J Rodriguez-Colunga; J Vazquez-Rojo; I Antolin; M P Carbajo; D Tolivia
Mast cells in the Harderian gland of female Syrian hamsters during the estrous cycle and pregnancy: effects of the light/dark cycle.
Journal of reproductive immunology 1993;25(1):51-61.
1992: A Menendez-Pelaez; Juan Mayo; Rosa M Sainz; M Perez; I Antolin; D Tolivia
Development and hormonal regulation of mast cells in the Harderian gland of Syrian hamsters.
Anatomy and embryology 1992;186(1):91-7.