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Hideyuki Saito

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Yuichi Uwai; Risa Taniguchi; Hideyuki Motohashi; Hideyuki Saito; Masahiro Okuda; Ken-ichi Inui
Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3.
Naoshi Horiba; Satohiro Masuda; Ayako Takeuchi; Hideyuki Saito; Masahiro Okuda; Ken-Ichi Inui
Gene expression variance based on random sequencing in rat remnant kidney.
Kayoko Ashida; Toshiya Katsura; Hideyuki Saito; Ken-ichi Inui
Decreased activity and expression of intestinal oligopeptide transporter PEPT1 in rats with hyperthyroidism in vivo.

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2004: Yuichi Uwai; Risa Taniguchi; Hideyuki Motohashi; Hideyuki Saito; Masahiro Okuda; Ken-ichi Inui
Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3.
Drug metabolism and pharmacokinetics 2004;19(5):369-74.
2004: Naoshi Horiba; Satohiro Masuda; Ayako Takeuchi; Hideyuki Saito; Masahiro Okuda; Ken-Ichi Inui
Gene expression variance based on random sequencing in rat remnant kidney.
Kidney international 2004;66(1):29-45.
2004: Kayoko Ashida; Toshiya Katsura; Hideyuki Saito; Ken-ichi Inui
Decreased activity and expression of intestinal oligopeptide transporter PEPT1 in rats with hyperthyroidism in vivo.
Pharmaceutical research 2004;21(6):969-75.
2004: Nobuhiko Nakamura; Satohiro Masuda; Kazushige Takahashi; Hideyuki Saito; Masahiro Okuda; Ken-ichi Inui
Decreased expression of glucose and peptide transporters in rat remnant kidney.
Drug metabolism and pharmacokinetics 2004;19(1):41-7.
2004: Hiroaki Yamaguchi; Ikuko Yano; Hideyuki Saito; Ken-ichi Inui
Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats.
Pharmaceutical research 2004;21(2):330-8.
2004: Yuji Sakurai; Hideyuki Motohashi; Harumasa Ueo; Satohiro Masuda; Hideyuki Saito; Masahiro Okuda; Noriko Mori; Motokazu Matsuura; Toshio Doi; Atsushi Fukatsu; Osamu Ogawa; Ken-ichi Inui
Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases.
Pharmaceutical research 2004;21(1):61-7.
2004: Yuichi Uwai; Satohiro Masuda; Maki Goto; Hideyuki Motohashi; Hideyuki Saito; Masahiro Okuda; Eijirou Nakamura; Noriyuki Ito; Osamu Ogawa; Ken-ichi Inui
Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients.
Journal of human genetics 2004;49(1):40-5.
2003: Toshiaki Igarashi; Ikuko Yano; Hideyuki Saito; Ken-Ichi Inui
Decreased cyclosporin A concentrations in the absorption phase using microemulsion preconcentrate formulation in rats with cisplatin-induced acute renal failure.
Biological & pharmaceutical bulletin 2003;26(11):1591-5.
2003: Satohiro Masuda; Maki Goto; Tetsuya Kiuchi; Shinji Uemoto; Takaaki Kodawara; Hideyuki Saito; Koichi Tanaka; Ken-ichi Inui
Enhanced expression of enterocyte P-glycoprotein depresses cyclosporine bioavailability in a recipient of living donor liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2003;9(10):1108-13.
2003: Yasushi Habu; Ikuko Yano; Ayako Takeuchi; Hideyuki Saito; Masahiro Okuda; Atsushi Fukatsu; Ken-ichi Inui
Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1, rOAT3 and rOCT2.
Biochemical pharmacology 2003;66(6):1107-14.
2003: Miyako Okamura; Tomohiro Terada; Toshiya Katsura; Hideyuki Saito; Ken-ichi Inui
Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and beta-lactam antibiotics in human intestinal cell line Caco-2.
Pharmaceutical research 2003;20(9):1389-93.
2003: Maki Goto; Satohiro Masuda; Hideyuki Saito; Ken-ichi Inui
Decreased expression of P-glycoprotein during differentiation in the human intestinal cell line Caco-2.
Biochemical pharmacology 2003;66(1):163-70.
2003: Shuichi Ohnishi; Hideyuki Saito; Atsuko Fukada; Ken-ichi Inui
Distinct transport activity of tetraethylammonium from L-carnitine in rat renal brush-border membranes.
Biochimica et biophysica acta 2003;1609(2):218-24.
2003: Masahide Fukudo; Ikuko Yano; Sachio Fukatsu; Hideyuki Saito; Shinji Uemoto; Tetsuya Kiuchi; Koichi Tanaka; Ken-ichi Inui
Forecasting of blood tacrolimus concentrations based on the Bayesian method in adult patients receiving living-donor liver transplantation.
Clinical pharmacokinetics 2003;42(13):1161-78.
2002: Yasushi Habu; Ikuko Yano; Yukiya Hashimoto; Hideyuki Saito; Ken-ichi Inui
p-Aminohippurate transport at the apical membrane in the OK kidney epithelial cell line.
Pharmaceutical research 2002;19(12):1822-6.
2002: Mari Jiko; Ikuko Yano; Hiroko Wakasugi; Hideyuki Saito; Ken-ichi Inui
Evaluation of pharmacokinetic interaction between cyclosporin A and probucol in rats.
Pharmaceutical research 2002;19(9):1362-7.
2002: Atsuko Fukada; Hideyuki Saito; Ken-Ichi Inui
Transport mechanisms of nicotine across the human intestinal epithelial cell line Caco-2.
The Journal of pharmacology and experimental therapeutics 2002;302(2):532-8.
2002: Lin Ji; Satohiro Masuda; Hideyuki Saito; Ken-ichi Inui
Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy.
Kidney international 2002;62(2):514-24.
2002: Yumiko Urakami; Maiko Akazawa; Hideyuki Saito; Masahiro Okuda; Ken-Ichi Inui
cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
Journal of the American Society of Nephrology : JASN 2002;13(7):1703-10.
2002: Xiaoyue Pan; Tomohiro Terada; Megumi Irie; Hideyuki Saito; Ken-Ichi Inui
Diurnal rhythm of H+-peptide cotransporter in rat small intestine.
American journal of physiology. Gastrointestinal and liver physiology 2002;283(1):G57-64.
2002: Takaaki Kodawara; Satohiro Masuda; Hiroko Wakasugi; Yuichi Uwai; Takahiro Futami; Hideyuki Saito; Takaaki Abe; Ken-ichi Inu
Organic anion transporter oatp2-mediated interaction between digoxin and amiodarone in the rat liver.
Pharmaceutical research 2002;19(6):738-43.
2002: Masahiro Shimomura; Satohiro Masuda; Hideyuki Saito; Seisuke Sakamoto; Shinji Uemoto; Koichi Tanaka; Ken-ichi Inui
Roles of the jejunum and ileum in the first-pass effect as absorptive barriers for orally administered tacrolimus.
The Journal of surgical research 2002;103(2):215-22.
2002: Kayoko Ashida; Toshiya Katsura; Hideyuki Motohashi; Hideyuki Saito; Ken-Ichi Inui
Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(4):G617-23.
2002: Hiroaki Yamaguchi; Ikuko Yano; Hideyuki Saito; Ken-ichi Inui
Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo.
The Journal of pharmacology and experimental therapeutics 2002;300(3):1063-9.
2002: Atsuko Fukada; Hideyuki Saito; Yumiko Urakami; Masahiro Okuda; Ken-ichi Inui
Involvement of specific transport system of renal basolateral membranes in distribution of nicotine in rats.
Drug metabolism and pharmacokinetics 2002;17(6):554-60.
2002: Yuichi Uwai; Hideyuki Saito; Ken-Ichi Inui
Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone.
Drug metabolism and pharmacokinetics 2002;17(2):125-9.
2002: Hiromi Okabe; Ikuko Yano; Yukiya Hashimoto; Hideyuki Saito; Ken-ichi Inui
Evaluation of increased bioavailability of tacrolimus in rats with experimental renal dysfunction.
The Journal of pharmacy and pharmacology 2002;54(1):65-70.
2001: Kazushige Takahashi; Satohiro Masuda; Nobuhiko Nakamura; Hideyuki Saito; Takahiro Futami; Toshio Doi; Ken Inui
Upregulation of H(+)-peptide cotransporter PEPT2 in rat remnant kidney.
American journal of physiology. Renal physiology 2001;281(6):F1109-16.
2001: Hiroaki Yamaguchi; Ikuko Yano; Hideyuki Saito; Ken Inui
Transport characteristics of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2.
European journal of pharmacology 2001;431(3):297-303.
2001: Yumiko Urakami; Masahiro Okuda; Satohiro Masuda; M Akazawa; Hideyuki Saito; Ken Inui
Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules.
Pharmaceutical research 2001;18(11):1528-34.
2001: K Sawada; Tomohiro Terada; Hideyuki Saito; Ken Inui
Distinct transport characteristics of basolateral peptide transporters between MDCK and Caco-2 cells.
Pflügers Archiv : European journal of physiology 2001;443(1):31-7.
2001: Ayako Takeuchi; Satohiro Masuda; Hideyuki Saito; T Abe; Ken Inui
Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2.
The Journal of pharmacology and experimental therapeutics 2001;299(1):261-7.
2001: Sachio Fukatsu; Ikuko Yano; T Igarashi; Tohru Hashida; K Takayanagi; Hideyuki Saito; Shinji Uemoto; Tetsuya Kiuchi; Kiyoji Tanaka; Ken Inui; K Tanaka; K Inui
Population pharmacokinetics of tacrolimus in adult recipients receiving living-donor liver transplantation.
European journal of clinical pharmacology 2001;57(6-7):479-84.
2001: Ayako Takeuchi; Satohiro Masuda; Hideyuki Saito; Toshio Doi; Ken Inui
Role of kidney-specific organic anion transporters in the urinary excretion of methotrexate.
Kidney international 2001;60(3):1058-68.
2001: S Ohnishi; Hideyuki Saito; Atsuko Fukada; Ken Inui
Independent organic cation transport activity of Na(+)-L-carnitine cotransport system in LLC-PK(1) cells.
American journal of physiology. Renal physiology 2001;281(2):F273-9.
2001: Megumi Irie; Tomohiro Terada; K Sawada; Hideyuki Saito; Ken Inui
Recognition and transport characteristics of nonpeptidic compounds by basolateral peptide transporter in Caco-2 cells.
The Journal of pharmacology and experimental therapeutics 2001;298(2):711-7.
2001: Hideyuki Motohashi; Toshiya Katsura; Hideyuki Saito; Ken Inui
Effects of tacrolimus and cyclosporin A on peptide transporter PEPT1 in Caco-2 cells.
Pharmaceutical research 2001;18(5):713-7.
2001: Tohru Hashida; Satohiro Masuda; Shinji Uemoto; Hideyuki Saito; Kiyoji Tanaka; Ken Inui
Pharmacokinetic and prognostic significance of intestinal MDR1 expression in recipients of living-donor liver transplantation.
Clinical pharmacology and therapeutics 2001;69(5):308-16.
2000: Yuichi Uwai; Hideyuki Saito; Ken Inui
Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter.
European journal of pharmacology 2000;409(1):31-6.
2000: Tomohiro Terada; K Sawada; T Ito; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Functional expression of novel peptide transporter in renal basolateral membranes.
American journal of physiology. Renal physiology 2000;279(5):F851-7.
2000: Yuichi Uwai; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1.
The Journal of pharmacology and experimental therapeutics 2000;295(1):261-5.
2000: Tomohiro Terada; K Sawada; Megumi Irie; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Structural requirements for determining the substrate affinity of peptide transporters PEPT1 and PEPT2.
Pflügers Archiv : European journal of physiology 2000;440(5):679-84.
2000: Ken Inui; Satohiro Masuda; Hideyuki Saito
Cellular and molecular aspects of drug transport in the kidney.
Kidney international 2000;58(3):944-58.
2000: Yuichi Uwai; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1.
European journal of pharmacology 2000;398(2):193-7.
2000: Ayako Takeuchi; Satohiro Masuda; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Trans-stimulation effects of folic acid derivatives on methotrexate transport by rat renal organic anion transporter, OAT-K1.
The Journal of pharmacology and experimental therapeutics 2000;293(3):1034-9.
2000: Yumiko Urakami; Masahiro Okuda; Hideyuki Saito; Ken Inui
Hormonal regulation of organic cation transporter OCT2 expression in rat kidney.
FEBS letters 2000;473(2):173-6.
2000: T Terada; K Sawada; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2.
European journal of pharmacology 2000;392(1-2):11-7.
2000: Ken Inui; Tomohiro Terada; Satohiro Masuda; Hideyuki Saito
Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2000;15 Suppl 6():11-3.
2000: Tomohiro Terada; Hideyuki Saito; K Sawada; Yukiya Hashimoto; Ken Inui
N-terminal halves of rat H+/peptide transporters are responsible for their substrate recognition.
Pharmaceutical research 2000;17(1):15-20.
1999: Yumiko Urakami; N Nakamura; K Takahashi; Masahiro Okuda; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Gender differences in expression of organic cation transporter OCT2 in rat kidney.
FEBS letters 1999;461(3):339-42.
1999: K Sawada; Tomohiro Terada; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Effects of glibenclamide on glycylsarcosine transport by the rat peptide transporters PEPT1 and PEPT2.
British journal of pharmacology 1999;128(6):1159-64.
1999: K Sawada; Tomohiro Terada; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Recognition of L-amino acid ester compounds by rat peptide transporters PEPT1 and PEPT2.
The Journal of pharmacology and experimental therapeutics 1999;291(2):705-9.
1999: Satohiro Masuda; Ayako Takeuchi; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Functional analysis of rat renal organic anion transporter OAT-K1: bidirectional methotrexate transport in apical membrane.
FEBS letters 1999;459(1):128-32.
1999: H Mizuuchi; Toshiya Katsura; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Transport characteristics of diphenhydramine in human intestinal epithelial Caco-2 cells: contribution of pH-dependent transport system.
The Journal of pharmacology and experimental therapeutics 1999;290(1):388-92.
1999: Tomohiro Terada; K Sawada; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Functional characteristics of basolateral peptide transporter in the human intestinal cell line Caco-2.
The American journal of physiology 1999;276(6 Pt 1):G1435-41.
1999: Satohiro Masuda; K Ibaramoto; Ayako Takeuchi; Hideyuki Saito; Yukiya Hashimoto; Ken Inui
Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney.
Molecular pharmacology 1999;55(4):743-52.
1999: Masahiro Okuda; Yumiko Urakami; Hideyuki Saito; Ken Inui
Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes.
Biochimica et biophysica acta 1999;1417(2):224-31.
1998: Yumiko Urakami; Masahiro Okuda; Satohiro Masuda; Hideyuki Saito; Ken Inui
Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs.
The Journal of pharmacology and experimental therapeutics 1998;287(2):800-5.
1998: Kazushige Takahashi; Nobuhiko Nakamura; Tomohiro Terada; T Okano; Takahiro Futami; Hideyuki Saito; Ken Inui
Interaction of beta-lactam antibiotics with H+/peptide cotransporters in rat renal brush-border membranes.
The Journal of pharmacology and experimental therapeutics 1998;286(2):1037-42.
1998: K Takami; Hideyuki Saito; Masahiro Okuda; Makoto Takano; Ken Inui
Distinct characteristics of transcellular transport between nicotine and tetraethylammonium in LLC-PK1 cells.
The Journal of pharmacology and experimental therapeutics 1998;286(2):676-80.
1998: Tomohiro Terada; Hideyuki Saito; Ken Inui
Interaction of beta-lactam antibiotics with histidine residue of rat H+/peptide cotransporters, PEPT1 and PEPT2.
The Journal of biological chemistry 1998;273(10):5582-5.
1997: Satohiro Masuda; Hideyuki Saito; Ken Inui
Interactions of nonsteroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-K1.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1039-42.
1997: Tomohiro Terada; Hideyuki Saito; M Mukai; Ken Inui
Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells.
The American journal of physiology 1997;273(5 Pt 2):F706-11.
1997: Hideyuki Saito
[Drug transporters in renal tubules].
Seikagaku. The Journal of Japanese Biochemical Society 1997;69(9):1094-8.
1997: Hideyuki Saito
[Molecular and cell biological analyses for intestinal absorption and renal excretion of drugs].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1997;117(8):522-41.
1997: Tomohiro Terada; Hideyuki Saito; M Mukai; Ken Inui
Characterization of stably transfected kidney epithelial cell line expressing rat H+/peptide cotransporter PEPT1: localization of PEPT1 and transport of beta-lactam antibiotics.
The Journal of pharmacology and experimental therapeutics 1997;281(3):1415-21.
1997: Satohiro Masuda; Hideyuki Saito; H Nonoguchi; K Tomita; Ken Inui
mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules.
FEBS letters 1997;407(2):127-31.
1997: Masahiro Okuda; Yumiko Urakami; Satohiro Masuda; Hideyuki Saito; Ken Inui
Characterization of organic ion transporters involved in renal excretion of xenobiotics.
The Japanese journal of physiology 1997;47 Suppl 1():S58-9.