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Toshiki Saito

Research Profile

Chemicals & Drugs

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Cell Lineage

Physiology

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Hematopoietic Stem Cells

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Publications

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J Kanda; C Mizumoto; Tatsuo Ichinohe; Hiroshi Kawabata; Toshiki Saito; Kouhei Yamashita; Tadakazu Kondo; Shunji Takakura; Satoshi Ichiyama; Takashi Uchiyama; Takayuki Ishikawa
Pretransplant serum ferritin and C-reactive protein as predictive factors for early bacterial infection after allogeneic hematopoietic cell transplantation.
J Kanda; Tatsuo Ichinohe; Toshiki Saito; K Yamashita; T Kondo; Takayuki Ishikawa; S Ichiyama; Takashi Uchiyama
Impact of discontinuing fluoroquinolone prophylaxis on early mortality after allogeneic marrow or peripheral blood SCT with myeloablative conditioning.
Yoichi Maekawa; Yoshiaki Minato; Chieko Ishifune; Takeshi Kurihara; Akiko Kitamura; Hidefumi Kojima; Hideo Yagita; Mamiko Sakata-Yanagimoto; Toshiki Saito; Ichiro Taniuchi; Shigeru Chiba; Saburo Sone; Koji Yasutomo
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.

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All Publications

2011: J Kanda; C Mizumoto; Tatsuo Ichinohe; Hiroshi Kawabata; Toshiki Saito; Kouhei Yamashita; Tadakazu Kondo; Shunji Takakura; Satoshi Ichiyama; Takashi Uchiyama; Takayuki Ishikawa
Pretransplant serum ferritin and C-reactive protein as predictive factors for early bacterial infection after allogeneic hematopoietic cell transplantation.
Bone marrow transplantation 2011;46(2):208-16.
2010: J Kanda; Tatsuo Ichinohe; Toshiki Saito; K Yamashita; T Kondo; Takayuki Ishikawa; S Ichiyama; Takashi Uchiyama
Impact of discontinuing fluoroquinolone prophylaxis on early mortality after allogeneic marrow or peripheral blood SCT with myeloablative conditioning.
Bone marrow transplantation 2010;45(8):1369-71.
2008: Yoichi Maekawa; Yoshiaki Minato; Chieko Ishifune; Takeshi Kurihara; Akiko Kitamura; Hidefumi Kojima; Hideo Yagita; Mamiko Sakata-Yanagimoto; Toshiki Saito; Ichiro Taniuchi; Shigeru Chiba; Saburo Sone; Koji Yasutomo
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.
Nature immunology 2008;9(10):1140-7.
2008: Mamiko Sakata-Yanagimoto; Etsuko Nakagami-Yamaguchi; Toshiki Saito; Keiki Kumano; Koji Yasutomo; Seishi Ogawa; Mineo Kurokawa; Shigeru Chiba
Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7839-44.
2008: Keiki Kumano; Shigeo Masuda; Masataka Sata; Toshiki Saito; Suk-Young Lee; Mamiko Sakata-Yanagimoto; Taisuke Tomita; Takeshi Iwatsubo; Hideaki Natsugari; Mineo Kurokawa; Seishi Ogawa; Shigeru Chiba
Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis.
Pigment cell & melanoma research 2008;21(1):70-8.
2005: Aleksandra Crcareva; Toshiki Saito; Atsushi Kunisato; Keiki Kumano; Takahiro Suzuki; Mamiko Sakata-Yanagimoto; Masahito Kawazu; Aleksandar Stojanovic; Mineo Kurokawa; Seishi Ogawa; Hisamaru Hirai; Shigeru Chiba
Hematopoietic stem cells expanded by fibroblast growth factor-1 are excellent targets for retrovirus-mediated gene delivery.
Experimental hematology 2005;33(12):1459-69.
2005: Sachiko Seo; Takashi Asai; Toshiki Saito; Takahiro Suzuki; Yasuyuki Morishita; Tetsuya Nakamoto; Motoshi Ichikawa; Go Yamamoto; Masahito Kawazu; Tetsuya Yamagata; Ryuichi Sakai; Kinuko Mitani; Seishi Ogawa; Mineo Kurokawa; Shigeru Chiba; Hisamaru Hirai
Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3492-501.
2005: Masahito Kawazu; Takashi Asai; Motoshi Ichikawa; Go Yamamoto; Toshiki Saito; Susumu Goyama; Kinuko Mitani; Kohei Miyazono; Shigeru Chiba; Seishi Ogawa; Mineo Kurokawa; Hisamaru Hirai
Functional domains of Runx1 are differentially required for CD4 repression, TCRbeta expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3526-33.
2004: Tetsuya Nakamoto; Akiko Shiratsuchi; Hideaki Oda; Keiichi Inoue; Tomoko Matsumura; Motoshi Ichikawa; Toshiki Saito; Sachiko Seo; Kazuhiro Maki; Takashi Asai; Takahiro Suzuki; Akira Hangaishi; Tetsuya Yamagata; Shinichi Aizawa; Masaki Noda; Yoshinobu Nakanishi; Hisamaru Hirai
Impaired spermatogenesis and male fertility defects in CIZ/Nmp4-disrupted mice.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(6):575-89.
2004: Atsushi Kunisato; Shigeru Chiba; Toshiki Saito; Keiki Kumano; Etsuko Nakagami-Yamaguchi; Tomoyuki Yamaguchi; Hisamaru Hirai
Stem cell leukemia protein directs hematopoietic stem cell fate.
Blood 2004;103(9):3336-41.
2004: Motoshi Ichikawa; Takashi Asai; Toshiki Saito; Sachiko Seo; Ieharu Yamazaki; Tetsuya Yamagata; Kinuko Mitani; Shigeru Chiba; Seishi Ogawa; Mineo Kurokawa; Hisamaru Hirai
AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.
Nature medicine 2004;10(3):299-304.
2003: Keiki Kumano; Shigeru Chiba; Atsushi Kunisato; Masataka Sata; Toshiki Saito; Etsuko Nakagami-Yamaguchi; Tomoyuki Yamaguchi; Shigeo Masuda; Kiyoshi Shimizu; Tokiharu Takahashi; Seishi Ogawa; Yoshio Hamada; Hisamaru Hirai
Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells.
Immunity 2003;18(5):699-711.
2003: Toshiki Saito; Shigeru Chiba; Motoshi Ichikawa; Atsushi Kunisato; Takashi Asai; Kiyoshi Shimizu; Tomoyuki Yamaguchi; Go Yamamoto; Sachiko Seo; Keiki Kumano; Etsuko Nakagami-Yamaguchi; Yoshio Hamada; Shinichi Aizawa; Hisamaru Hirai
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.
Immunity 2003;18(5):675-85.
2003: Atsushi Kunisato; Shigeru Chiba; Etsuko Nakagami-Yamaguchi; Keiki Kumano; Toshiki Saito; Shigeo Masuda; Tomoyuki Yamaguchi; Masatake Osawa; Ryoichiro Kageyama; Hiromitsu Nakauchi; Mitsuo Nishikawa; Hisamaru Hirai
HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo.
Blood 2003;101(5):1777-83.
2002: Shigeru Chiba; Akiko Saito; Seishi Ogawa; Kengo Takeuchi; K Kumano; S Seo; Takahiro Suzuki; Yuji Tanaka; Toshiki Saito; Koji Izutsu; Koichiro Yuji; S Masuda; Satoru Futami; Masamichi Nishida; G Suzuki; R P Gale; M Fukayama; Kazuhiko Maekawa; Hisamura Hirai
Transplantation for accidental acute high-dose total body neutron- and gamma-radiation exposure.
Bone marrow transplantation 2002;29(11):935-9.
2002: Kiyoshi Shimizu; Shigeru Chiba; Toshiki Saito; Keiki Kumano; Yoshio Hamada; Hisamaru Hirai
Functional diversity among Notch1, Notch2, and Notch3 receptors.
Biochemical and biophysical research communications 2002;291(4):775-9.
2002: Kunihisa Nakai; Yoshinobu Kanda; Shin Mineishi; Toshiki Saito; Mutsuko Ohnishi; Hironari Niiya; Aki Chizuka; Tsutomu Takeuchi; Hiroshi Matsubara; Masahiro Kami; Atsushi Makimoto; Ryuji Tanosaki; Hideo Kunitoh; Kensei Tobinai; Yoichi Takaue
Suspected delayed immune recovery against cytomegalovirus after reduced-intensity stem cell transplantation using anti-thymocyte globulin.
Bone marrow transplantation 2002;29(3):237-41.
2002: Kiyoshi Shimizu; Shigeru Chiba; Toshiki Saito; Tokiharu Takahashi; Keiki Kumano; Yoshio Hamada; Hisamaru Hirai
Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.
The EMBO journal 2002;21(3):294-302.
2001: Keiki Kumano; Shigeru Chiba; Kiyoshi Shimizu; Tetsuya Yamagata; Noriko Hosoya; Toshiki Saito; Tokiharu Takahashi; Yoshio Hamada; Hisamura Hirai
Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression.
Blood 2001;98(12):3283-9.
2001: Yoshinobu Kanda; Shin Mineishi; Toshiki Saito; Akiko Saito; S Yamada; Mutsuko Ohnishi; Aki Chizuka; Hironari Niiya; K Suenaga; Kunihisa Nakai; Tsutomu Takeuchi; Atsushi Makimoto; Ryuji Tanosaki; Masahiro Kami; Yuji Tanaka; S Fujita; Tsutomu Watanabe; Yukio Kobayashi; Kensei Tobinai; Yoichi Takaue
Long-term low-dose acyclovir against varicella-zoster virus reactivation after allogeneic hematopoietic stem cell transplantation.
Bone marrow transplantation 2001;28(7):689-92.
2001: Hironari Niiya; Yoshinobu Kanda; Toshiki Saito; Toshihiro Ohnishi; Sachiyo Kanai; Y Kawano; K Kamijo; A Iizuka; Kimikazu Yakushijin; K Ueda; Aki Chizuka; K Iijima; Mutsuko Ohnishi; Kunihisa Nakai; Atsushi Makimoto; Ryuji Tanosaki; Kensei Tobinai; H Wakasugi; Yoichi Takaue; Shin Mineishi
Early full donor myeloid chimerism after reduced-intensity stem cell transplantation using a combination of fludarabine and busulfan.
Haematologica 2001;86(10):1071-4.
2001: Kiyoshi Shimizu; Shigeru Chiba; Toshiki Saito; Keiki Kumano; Tokiharu Takahashi; Hisamura Hirai
Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation.
The Journal of biological chemistry 2001;276(28):25753-8.
2001: K Suenaga; Yoshinobu Kanda; Hironari Niiya; Kunihisa Nakai; Toshiki Saito; Akiko Saito; Mutsuko Ohnishi; Tsutomu Takeuchi; Ryuji Tanosaki; Atsushi Makimoto; S Miyawaki; Toshihiro Ohnishi; Sachiyo Kanai; Kensei Tobinai; Yoichi Takaue; Shin Mineishi
Successful application of nonmyeloablative transplantation for paroxysmal nocturnal hemoglobinuria.
Experimental hematology 2001;29(5):639-42.
2001: Yoshinobu Kanda; Shin Mineishi; Toshiki Saito; S Seo; Akiko Saito; K Suenaga; Mutsuko Ohnishi; Hironari Niiya; Kunihisa Nakai; Tsutomu Takeuchi; N Kawahigashi; N Shoji; T Ogasawara; Ryuji Tanosaki; Yukio Kobayashi; Kensei Tobinai; Masahiro Kami; S Mori; R Suzuki; Hideo Kunitoh; Yoichi Takaue
Pre-emptive therapy against cytomegalovirus (CMV) disease guided by CMV antigenemia assay after allogeneic hematopoietic stem cell transplantation: a single-center experience in Japan.
Bone marrow transplantation 2001;27(4):437-44.
2000: Kiyoshi Shimizu; Shigeru Chiba; Toshiki Saito; Keiki Kumano; Hisamura Hirai
Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.
Biochemical and biophysical research communications 2000;276(1):385-9.
2000: Kiyoshi Shimizu; Shigeru Chiba; Noriko Hosoya; Keiki Kumano; Toshiki Saito; Mineo Kurokawa; Yoshinobu Kanda; Yoshio Hamada; Hisamura Hirai
Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.
Molecular and cellular biology 2000;20(18):6913-22.
1999: Yoshinobu Kanda; Shigeru Chiba; Yuji Tanaka; Masahiro Kami; Toshiki Saito; Koji Izutsu; Takashi Asai; Koichiro Yuji; Seishi Ogawa; Hiroaki Honda; Kinuko Mitani; Kensuke Usuki; A Urabe; K Shirakawa; T Yatomi; N Nakamura; Yoshio Yazaki; Hisamura Hirai
Increased serum soluble Fas ligand associated with recurrent B-cell non-Hodgkin's lymphoma after autologous peripheral blood stem cell transplantation.
Leukemia & lymphoma 1999;34(5-6):625-8.
1999: Toshiki Saito; Tetsuya Yamagata; Tokiharu Takahashi; Hiroaki Honda; Hisamura Hirai
ICSAT overexpression is not sufficient to cause adult T-cell leukemia or multiple myeloma.
Biochemical and biophysical research communications 1999;260(2):329-31.
1999: Yoshinobu Kanda; Yuji Tanaka; Masahiro Kami; Toshiki Saito; Takashi Asai; Koji Izutsu; Koichiro Yuji; Seishi Ogawa; Hiroaki Honda; Kinuko Mitani; Shigeru Chiba; Yoshio Yazaki; Hisamura Hirai
TT virus in bone marrow transplant recipients.
Blood 1999;93(8):2485-90.
1999: Yoshinobu Kanda; Shigeru Chiba; Yuji Tanaka; Masahiro Kami; Toshiki Saito; Takashi Asai; Koji Izutsu; Koichiro Yuji; Seishi Ogawa; Hiroaki Honda; Kinuko Mitani; Yoshio Yazaki; Hisamura Hirai
TT virus in frequently transfused patients.
The American journal of medicine 1999;106(1):116-7.
1998: Yoshinobu Kanda; Yuji Tanaka; K Shirakawa; T Yatomi; N Nakamura; Masahiro Kami; Toshiki Saito; Koji Izutsu; Takashi Asai; Koichiro Yuji; Seishi Ogawa; Hiroaki Honda; Kinuko Mitani; Shigeru Chiba; Yoshio Yazaki; Hisamura Hirai
Increased soluble Fas-ligand in sera of bone marrow transplant recipients with acute graft-versus-host disease.
Bone marrow transplantation 1998;22(8):751-4.
1998: Shoichiro Miyatake; C Nakaseko; Hisashi Umemori; Tadashi Yamamoto; Toshiki Saito
Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).
Biochemical and biophysical research communications 1998;249(2):444-8.
1998: Masahiro Kami; Yoshinobu Kanda; M Sasaki; N Takeda; Yuji Tanaka; Toshiki Saito; Seishi Ogawa; Hiroaki Honda; Shigeru Chiba; Kinuko Mitani; Hisamura Hirai; Yoshio Yazaki
Phimosis as a manifestation of chronic graft-versus-host disease after allogeneic bone marrow transplantation.
Bone marrow transplantation 1998;21(7):721-3.
1998: Tokiharu Takahashi; Yoshinobu Kanda; M Mori; Toshiki Saito; Shigeru Chiba; Kinuko Mitani; Hisamura Hirai; Yoshio Yazaki
B cell lymphoma-associated hemophagocytic syndrome after PBSCT.
Bone marrow transplantation 1998;21(6):623-5.
1987: T Meshi; Yoshinori Watanabe; Toshiki Saito; A Sugimoto; Toyoki Maeda; Yasushi Okada
Function of the 30 kd protein of tobacco mosaic virus: involvement in cell-to-cell movement and dispensability for replication.
The EMBO journal 1987;6(9):2557-63.