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Yoshiro Saito

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Keiko Maekawa; Yumiko Matsuzawa; Naoto Minamino; Mayumi Murayama; Hiroki Nakanishi; Tomoko Nishimaki-Mogami; Hiroshi Abe; Makoto Arita; Akiyoshi Hirayama; Kazutaka Ikeda; Masaki Ishikawa; Yuko Iwata; Tomoyoshi Soga; Shoko Sugawara; Ryo Taguchi; Yoko Tajima; Noriko Ueno; Shigeo Wakabayashi; Yoshiro Saito
Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy.
Nahoko Kaniwa; Yoshiro Saito
Pharmacogenomics of severe cutaneous adverse reactions.
Kiyoshi Fukuhara; Masaaki Kurihara; Keiko Maekawa; Shumpei Niida; Akiko Ohno; Haruhiro Okuda; Alato Okuno; Yosuke Ota; Yoshiro Saito; Yuya Senoo; Osamu Takikawa
NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers.

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All Publications

2013: Keiko Maekawa; Yumiko Matsuzawa; Naoto Minamino; Mayumi Murayama; Hiroki Nakanishi; Tomoko Nishimaki-Mogami; Hiroshi Abe; Makoto Arita; Akiyoshi Hirayama; Kazutaka Ikeda; Masaki Ishikawa; Yuko Iwata; Tomoyoshi Soga; Shoko Sugawara; Ryo Taguchi; Yoko Tajima; Noriko Ueno; Shigeo Wakabayashi; Yoshiro Saito
Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy.
Journal of molecular and cellular cardiology 2013;59():76-85.
2013: Nahoko Kaniwa; Yoshiro Saito
Pharmacogenomics of severe cutaneous adverse reactions.
Pharmacogenomics 2013;14(6):595-8.
2013: Kiyoshi Fukuhara; Masaaki Kurihara; Keiko Maekawa; Shumpei Niida; Akiko Ohno; Haruhiro Okuda; Alato Okuno; Yosuke Ota; Yoshiro Saito; Yuya Senoo; Osamu Takikawa
NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers.
Journal of clinical biochemistry and nutrition 2013;52(2):133-8.
2013: Masahiro Tohkin; M Ueta; M Abe; M Aihara; H Furuya; Ryuichi Hasegawa; H Ikeda; Zenro Ikezawa; Nahoko Kaniwa; S Kinoshita; Kouichi Kurose; Kayoko Matsunaga; M Muramatsu; J Nishikawa; Yoshiro Saito; Chie Sotozono; Emiko Sugiyama; Yukitoshi Takahashi
A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.
The pharmacogenomics journal 2013;13(1):60-9.
2013: Masaki Ishikawa; Keiko Maekawa; Mayumi Murayama; Yuya Senoo; Yoko Tajima; Yoshiro Saito
Plasma and serum from nonfasting men and women differ in their lipidomic profiles.
Biological & pharmaceutical bulletin 2013;36(4):682-5.
2012: Minoru Tada; Takashi Ura; Yasuhide Yamada; Teruhiko Yoshida; Takayuki Yoshino; Toshihiko Doi; Hiromi Fukushima-Uesaka; Nozomu Fuse; Tetsuya Hamaguchi; Akiko Ishii-Watabe; Nahoko Kaniwa; Ken Kato; Nana Kawasaki; Kouichi Kurose; Keiko Maekawa; Kei Muro; Takako Eguchi Nakajima; Atsushi Ohtsu; Haruhiro Okuda; Nagahiro Saijo; Miyuki Saito; Yoshiro Saito; Jun-Ichi Sawada; Yasuhiro Shimada; Takuo Suzuki; Yasuhiro Matsumura
Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant.
Immunogenetics 2012;64(12):869-77.
2012: Kouichi Kurose; Jun Nishikawa; Shinpei Nonen; Gaku Okugawa; Junichi Azuma; Ryuichi Hasegawa; Kazuyuki Hiratsuka; Kazuya Ishiwata; Masaki Kato; Toshihiko Kinoshita; Toru Kurosawa; Masataka Wakeno; Yoshiro Saito
Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression.
Psychiatry research 2012;198(3):424-9.
2012: Kouichi Kurose; Yoshiro Saito
[Pharmacogenomics for adverse drug reactions].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 6():18-24.
2012: Katsunori Segawa; Tatsuya Nakano; Yoshiro Saito
[Renewal of NIHS computer network system].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2012;(130):75-7.
2012: Chie Sudo; Katsunori Segawa; Tadaaki Hanatani; Keiko Maekawa; Kimie Sai; Yoshiro Saito
[Trends in drug-induced liver injury based on reports of adverse reactions to PMDA in Japan].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2012;(130):66-70.
2012: Kouichi Kurose; Keiko Maekawa; Jun Nishikawa; Tomoko Koizumi; Yoshiro Saito
Quality requirements for genomic DNA preparations and storage conditions for a high-density oligonucleotide microarray.
Biological & pharmaceutical bulletin 2012;35(10):1846-8.
2012: Yuichiro Azuma; Yasuhiro Fujiwara; Kojiro Hata; Akihiro Hirakawa; Yoshinori Makino; Norifumi Morikawa; Yasuaki Ryushima; Kimie Sai; Yoshiro Saito; Masahiro Tohkin; Ryoko Udagawa; Nobuaki Yokote; Hiroshi Yamamoto
Significant association between hand-foot syndrome and efficacy of capecitabine in patients with metastatic breast cancer.
Biological & pharmaceutical bulletin 2012;35(5):717-24.
2012: Keiko Maekawa; Jun Nishikawa; Nahoko Kaniwa; Tomoko Koizumi; Kouichi Kurose; Emiko Sugiyama; Masahiro Tohkin; Yoshiro Saito
Development of a rapid and inexpensive assay for detecting a surrogate genetic polymorphism of HLA-B*58:01: a partially predictive but useful biomarker for allopurinol-related Stevens-Johnson syndrome/toxic epidermal necrolysis in Japanese.
Drug metabolism and pharmacokinetics 2012;27(4):447-50.
2012: Kouichi Kurose; Emiko Sugiyama; Yoshiro Saito
Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: implications in the clinical trials for novel drug development.
Drug metabolism and pharmacokinetics 2012;27(1):9-54.
2011: Kimie Sai; Yoshiro Saito
Ethnic differences in the metabolism, toxicology and efficacy of three anticancer drugs.
Expert opinion on drug metabolism & toxicology 2011;7(8):967-88.
2011: Nobumitsu Hanioka; Kimiaki Matsumoto; Yoshiro Saito; Shizuo Narimatsu
Influence of CYP2C8*13 and CYP2C8*14 alleles on amiodarone N-deethylation.
Basic & clinical pharmacology & toxicology 2011;108(5):359-62.
2011: Yoshiro Saito
[Pharmacogenomic research for avoiding adverse reactions by anti-cancer drugs].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2011;131(2):239-46.
2011: Chie Sudo; Yu-ichiro Azuma; Nahoko Kaniwa; Keiko Maekawa; Kimie Sai; Yoshiro Saito
[Current movements of four serious adverse events induced by medicinal drugs based on spontaneous reports in Japan].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2011;(129):111-7.
2011: Yoshiro Saito; Noboru Yamamoto; Noriko Katori; Keiko Maekawa; Hiromi Fukushima-Uesaka; Daisuke Sugimoto; Kouichi Kurose; Kimie Sai; Nahoko Kaniwa; Jun-Ichi Sawada; Hideo Kunitoh; Yuichiro Ohe; Teruhiko Yoshida; Yasuhiro Matsumura; Nagahiro Saijo; Haruhiro Okuda; Tomohide Tamura
Genetic polymorphisms and haplotypes of por, encoding cytochrome p450 oxidoreductase, in a Japanese population.
Drug metabolism and pharmacokinetics 2011;26(1):107-16.
2010: Nahoko Kaniwa; Yoshiro Saito; Michiko Aihara; Kayoko Matsunaga; Masahiro Tohkin; Kouichi Kurose; Hirokazu Furuya; Yukitoshi Takahashi; Masaaki Muramatsu; Shigeru Kinoshita; Masamichi Abe; Hiroko Ikeda; Mariko Kashiwagi; Yixuan Song; Mayumi Ueta; Chie Sotozono; Zenro Ikezawa; Ryuichi Hasegawa
HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.
Epilepsia 2010;51(12):2461-5.
2010: Keiko Maekawa; Noriko Harakawa; Takuya Yoshimura; Su-Ryang Kim; Yoshiyuki Fujimura; Fumika Aohara; Kimie Sai; Noriko Katori; Masahiro Tohkin; Mikihiko Naito; Ryuichi Hasegawa; Haruhiro Okuda; Jun-ichi Sawada; Takuro Niwa; Yoshiro Saito
CYP3A4*16 and CYP3A4*18 alleles found in East Asians exhibit differential catalytic activities for seven CYP3A4 substrate drugs.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(12):2100-4.
2010: Yoshiro Saito; Kimie Sai; Jun-ichi Sawada
[Pharmacogenomics for adverse drug reactions].
Nihon rinsho. Japanese journal of clinical medicine 2010;68 Suppl 8():263-8.
2010: Kimie Sai; Yoshiro Saito; Naoko Tatewaki; Masakiyo Hosokawa; Nahoko Kaniwa; Tomoko Nishimaki-Mogami; Mikihiko Naito; Jun-Ichi Sawada; Kuniaki Shirao; Tetsuya Hamaguchi; Noboru Yamamoto; Hideo Kunitoh; Tomohide Tamura; Yasuhide Yamada; Yuichiro Ohe; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Yasuhiro Matsumura; Nagahiro Saijo; Haruhiro Okuda
Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients.
British journal of clinical pharmacology 2010;70(2):222-33.
2010: Emiko Sugiyama; Nahoko Kaniwa; Su-Ryang Kim; Ryuichi Hasegawa; Yoshiro Saito; Hideki Ueno; Takuji Okusaka; Masafumi Ikeda; Chigusa Morizane; Shunsuke Kondo; Noboru Yamamoto; Tomohide Tamura; Junji Furuse; Hiroshi Ishii; Teruhiko Yoshida; Nagahiro Saijo; Jun-Ichi Sawada
Population pharmacokinetics of gemcitabine and its metabolite in Japanese cancer patients: impact of genetic polymorphisms.
Clinical pharmacokinetics 2010;49(8):549-58.
2010: Nobumitsu Hanioka; Kimiaki Matsumoto; Yoshiro Saito; Shizuo Narimatsu
Functional characterization of CYP2C8.13 and CYP2C8.14: catalytic activities toward paclitaxel.
Basic & clinical pharmacology & toxicology 2010;107(1):565-9.
2010: Kimie Sai; Yoshiro Saito; Keiko Maekawa; Su-Ryang Kim; Nahoko Kaniwa; Tomoko Nishimaki-Mogami; Jun-ichi Sawada; Kuniaki Shirao; Tetsuya Hamaguchi; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Yasuhide Yamada; Tomohide Tamura; Teruhiko Yoshida; Yasuhiro Matsumura; Atsushi Ohtsu; Nagahiro Saijo; Hironobu Minami
Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients.
Cancer chemotherapy and pharmacology 2010;66(1):95-105.
2010: Akiko Ishii-Watabe; Yoshiro Saito; Takuo Suzuki; Minoru Tada; Maho Ukaji; Keiko Maekawa; Kouichi Kurose; Nahoko Kaniwa; Jun-ichi Sawada; Nana Kawasaki; Teruhide Yamaguchi; Takako Eguchi Nakajima; Ken Kato; Yasuhide Yamada; Yasuhiro Shimada; Teruhiko Yoshida; Takashi Ura; Miyuki Saito; Kei Muro; Toshihiko Doi; Nozomu Fuse; Takayuki Yoshino; Atsushi Ohtsu; Nagahiro Saijo; Tetsuya Hamaguchi; Haruhiro Okuda; Yasuhiro Matsumura
Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis.
Drug metabolism and pharmacokinetics 2010;25(6):578-87.
2010: Masahiro Tohkin; Akihiro Ishiguro; Nahoko Kaniwa; Yoshiro Saito; Kouichi Kurose; Ryuichi Hasegawa
Prediction of severe adverse drug reactions using pharmacogenetic biomarkers.
Drug metabolism and pharmacokinetics 2010;25(2):122-33.
2010: H Suzuki; Yoshiro Saito; Ichiro Oda; S Nonaka; Yukihiro Nakanishi
Feasibility of endoscopic mucosal resection for superficial pharyngeal cancer: a minimally invasive treatment.
Endoscopy 2010;42(1):1-7.
2009: Keiko Maekawa; Noriko Harakawa; Emiko Sugiyama; Masahiro Tohkin; Su-Ryang Kim; Nahoko Kaniwa; Noriko Katori; Ryuichi Hasegawa; Kazuki Yasuda; Kei Kamide; Toshiyuki Miyata; Yoshiro Saito; Jun-ichi Sawada
Substrate-dependent functional alterations of seven CYP2C9 variants found in Japanese subjects.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(9):1895-903.
2009: Yoshiro Saito; Jun-ichi Sawada
[Pharmacogenomics].
Nihon rinsho. Japanese journal of clinical medicine 2009;67(6):1175-9.
2009: Hiromi Fukushima-Uesaka; Yoshiro Saito; Keiko Maekawa; Kouichi Kurose; Emiko Sugiyama; Noriko Katori; Nahoko Kaniwa; Ryuichi Hasegawa; Tetsuya Hamaguchi; Takako Eguchi-Nakajima; Ken Kato; Yasuhide Yamada; Yasuhiro Shimada; Teruhiko Yoshida; Noboru Yamamoto; Hiroshi Nokihara; Hideo Kunitoh; Yuichiro Ohe; Tomohide Tamura; Takashi Ura; Miyuki Saito; Kei Muro; Toshihiko Doi; Nozomu Fuse; Takayuki Yoshino; Atsushi Ohtsu; Nagahiro Saijo; Yasuhiro Matsumura; Haruhiro Okuda; Jun-ichi Sawada
Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients.
Drug metabolism and pharmacokinetics 2009;24(6):565-74.
2009: Emiko Sugiyama; Su-Jun Lee; Sang Seop Lee; Woo-Young Kim; Su-Ryang Kim; Masahiro Tohkin; Ryuichi Hasegawa; Haruhiro Okuda; Manabu Kawamoto; Naoyuki Kamatani; Jun-Ichi Sawada; Nahoko Kaniwa; Yoshiro Saito; Jae-Gook Shin
Ethnic differences of two non-synonymous single nucleotide polymorphisms in CDA gene.
Drug metabolism and pharmacokinetics 2009;24(6):553-6.
2009: Su-Ryang Kim; Yoshiro Saito; Masaya Itoda; Keiko Maekawa; Manabu Kawamoto; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Genetic variations of the ABC transporter gene ABCB11 encoding the human bile salt export pump (BSEP) in a Japanese population.
Drug metabolism and pharmacokinetics 2009;24(3):277-81.
2009: Naoko Tatewaki; Keiko Maekawa; Noriko Katori; Kouichi Kurose; Nahoko Kaniwa; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Hiroshi Nokihara; Ikuo Sekine; Tomohide Tamura; Teruhiko Yoshida; Nagahiro Saijo; Yoshiro Saito; Jun-ichi Sawada
Genetic variations and haplotype structures of the glutathione S-transferase genes, GSTT1 and GSTM1, in a Japanese patient population.
Drug metabolism and pharmacokinetics 2009;24(1):118-26.
2008: Nahoko Kaniwa; Yoshiro Saito; Michiko Aihara; Kayoko Matsunaga; Masahiro Tohkin; Kouichi Kurose; Jun-ichi Sawada; Hirokazu Furuya; Yukitoshi Takahashi; Masaaki Muramatsu; Shigeru Kinoshita; Masamichi Abe; Hiroko Ikeda; Mariko Kashiwagi; Yixuan Song; Mayumi Ueta; Chie Sotozono; Zenro Ikezawa; Ryuichi Hasegawa
HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis.
Pharmacogenomics 2008;9(11):1617-22.
2008: Nobumitsu Hanioka; Yumi Tsuneto; Yoshiro Saito; Keiko Maekawa; Jun-Ichi Sawada; Shizuo Narimatsu
Influence of CYP2C19*18 and CYP2C19*19 alleles on omeprazole 5-hydroxylation: in vitro functional analysis of recombinant enzymes expressed in Saccharomyces cerevisiae.
Basic & clinical pharmacology & toxicology 2008;102(4):388-93.
2008: Su-Ryang Kim; Yoshiro Saito; Keiko Maekawa; Emiko Sugiyama; Nahoko Kaniwa; Hideki Ueno; Takuji Okusaka; Masafumi Ikeda; Chigusa Morizane; Noboru Yamamoto; Teruhiko Yoshida; Naoyuki Kamatani; Junji Furuse; Hiroshi Ishii; Nagahiro Saijo; Shogo Ozawa; Jun-Ichi Sawada
Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK).
Drug metabolism and pharmacokinetics 2008;23(5):379-84.
2008: Kimie Sai; Yoshiro Saito; Masaya Itoda; Hiromi Fukushima-Uesaka; Tomoko Nishimaki-Mogami; Shogo Ozawa; Keiko Maekawa; Kouichi Kurose; Nahoko Kaniwa; Manabu Kawamoto; Naoyuki Kamatani; Kuniaki Shirao; Tetsuya Hamaguchi; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Yasuhide Yamada; Tomohide Tamura; Teruhiko Yoshida; Hironobu Minami; Yasuhiro Matsumura; Atsushi Ohtsu; Nagahiro Saijo; Jun-ichi Sawada
Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population.
Drug metabolism and pharmacokinetics 2008;23(2):139-47.
2007: Maho Ukaji; Yoshiro Saito; Hiromi Fukushima-Uesaka; Keiko Maekawa; Noriko Katori; Nahoko Kaniwa; Teruhiko Yoshida; Hiroshi Nokihara; Ikuo Sekine; Hideo Kunitoh; Yuichiro Ohe; Noboru Yamamoto; Tomohide Tamura; Nagahiro Saijo; Jun-ichi Sawada
Genetic variations of VDR/NR1I1 encoding vitamin D receptor in a Japanese population.
Drug metabolism and pharmacokinetics 2007;22(6):462-7.
2007: Su-Ryang Kim; Yoshiro Saito; Kimie Sai; Kouichi Kurose; Keiko Maekawa; Nahoko Kaniwa; Shogo Ozawa; Naoyuki Kamatani; Kuniaki Shirao; Noboru Yamamoto; Tetsuya Hamaguchi; Hideo Kunitoh; Yuichiro Ohe; Yasuhide Yamada; Tomohide Tamura; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Nagahiro Saijo; Jun-ichi Sawada
Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B1*17 is more prevalent than *15.
Drug metabolism and pharmacokinetics 2007;22(6):456-61.
2007: Jun-ichi Sawada; Yoshiro Saito
[Prediction of adverse drug reactions based on genomic information].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 8():16-21.
2007: Su-Ryang Kim; Kimie Sai; Toshiko Tanaka-Kagawa; Hideto Jinno; Shogo Ozawa; Nahoko Kaniwa; Yoshiro Saito; Akira Akasawa; Kenji Matsumoto; Hirohisa Saito; Naoyuki Kamatani; Kuniaki Shirao; Noboru Yamamoto; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Nagahiro Saijo; Jun-ichi Sawada
Haplotypes and a novel defective allele of CES2 found in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1865-72.
2007: Yoshiro Saito; Noriko Katori; Akiko Soyama; Yukiko Nakajima; Takashi Yoshitani; Su-Ryang Kim; Hiromi Fukushima-Uesaka; Kouichi Kurose; Nahoko Kaniwa; Shogo Ozawa; Naoyuki Kamatani; Kazuo Komamura; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kenji Sugai; Narihiro Minami; Hideo Kimura; Yu-ichi Goto; Hironobu Minami; Teruhiko Yoshida; Hideo Kunitoh; Yuichiro Ohe; Noboru Yamamoto; Tomohide Tamura; Nagahiro Saijo; Jun-ichi Sawada
CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population.
Pharmacogenetics and genomics 2007;17(7):461-71.
2007: Hiromi Fukushima-Uesaka; Yoshiro Saito; Keiko Maekawa; Naoyuki Kamatani; Hiroshi Kajio; Nobuaki Kuzuya; Mitsuhiko Noda; Kazuki Yasuda; Jun-ichi Sawada
Genetic variations and haplotype structures of transcriptional factor Nrf2 and its cytosolic reservoir protein Keap1 in Japanese.
Drug metabolism and pharmacokinetics 2007;22(3):212-9.
2007: Hiromi Fukushima-Uesaka; Yoshiro Saito; Keiko Maekawa; Ryuichi Hasegawa; Kazuko Suzuki; Tatsuo Yanagawa; Hiroshi Kajio; Nobuaki Kuzuya; Mitsuhiko Noda; Kazuki Yasuda; Masahiro Tohkin; Jun-ichi Sawada
Genetic variations of the ABC transporter gene ABCC3 in a Japanese population.
Drug metabolism and pharmacokinetics 2007;22(2):129-35.
2007: Nobumitsu Hanioka; Yumi Tsuneto; Yoshiro Saito; T Sumada; Keiko Maekawa; Keita Saito; Jun-ichi Sawada; Shizuo Narimatsu
Functional characterization of two novel CYP2C19 variants (CYP2C19*18 and CYP2C19*19) found in a Japanese population.
Xenobiotica; the fate of foreign compounds in biological systems 2007;37(4):342-55.
2007: Hiromi Fukushima-Uesaka; Yoshiro Saito; Masahiro Tohkin; Keiko Maekawa; Ryuichi Hasegawa; Manabu Kawamoto; Naoyuki Kamatani; Kazuko Suzuki; Tatsuo Yanagawa; Hiroshi Kajio; Nobuaki Kuzuya; Kazuki Yasuda; Jun-ichi Sawada
Genetic variations and haplotype structures of the ABC transporter gene ABCC1 in a Japanese population.
Drug metabolism and pharmacokinetics 2007;22(1):48-60.
2007: Keiko Maekawa; Mayumi Saeki; Yoshiro Saito; Shogo Ozawa; Kouichi Kurose; Nahoko Kaniwa; Manabu Kawamoto; Naoyuki Kamatani; Ken Kato; Tetsuya Hamaguchi; Yasuhide Yamada; Kuniaki Shirao; Yasuhiro Shimada; Manabu Muto; Toshihiko Doi; Atsushi Ohtsu; Teruhiko Yoshida; Yasuhiro Matsumura; Nagahiro Saijo; Jun-ichi Sawada
Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences.
Journal of human genetics 2007;52(10):804-19.
2007: Emiko Sugiyama; Nahoko Kaniwa; Su-Ryang Kim; Ruri Kikura-Hanajiri; Ryuichi Hasegawa; Keiko Maekawa; Yoshiro Saito; Shogo Ozawa; Jun-ichi Sawada; Naoyuki Kamatani; Junji Furuse; Hiroshi Ishii; Teruhiko Yoshida; Hideki Ueno; Takuji Okusaka; Nagahiro Saijo
Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(1):32-42.
2006: Su-Ryang Kim; Shogo Ozawa; Yoshiro Saito; Kouichi Kurose; Nahoko Kaniwa; Naoyuki Kamatani; Tetsuya Hamaguchi; Kuniaki Shirao; Manabu Muto; Atsushi Ohtsu; Teruhiko Yoshida; Yasuhiro Matsumura; Nagahiro Saijo; Jun-ichi Sawada
Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS).
Drug metabolism and pharmacokinetics 2006;21(6):509-16.
2006: Akiko Soyama; Yoshiro Saito; Yasuo Ohno; Kazuo Komamura; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Shogo Ozawa; Jun-ichi Sawada
Diverse structures of chimeric CYP-REP7/6-containing CYP2D6 and a novel defective CYP2D6 haplotype harboring single-type *36 and CYP-REP7/6 in Japanese.
Drug metabolism and pharmacokinetics 2006;21(5):395-405.
2006: Kimie Sai; Masaya Itoda; Yoshiro Saito; Kouichi Kurose; Noriko Katori; Nahoko Kaniwa; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Hitonobu Tomoike; Shiro Kamakura; Masafumi Kitakaze; Toru Tamura; Noboru Yamamoto; Hideo Kunitoh; Yasuhide Yamada; Yuichiro Ohe; Yasuhiro Shimada; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Genetic variations and haplotype structures of the ABCB1 gene in a Japanese population: an expanded haplotype block covering the distal promoter region, and associated ethnic differences.
Annals of human genetics 2006;70(Pt 5):605-22.
2006: Hiromi Fukushima-Uesaka; Yoshiro Saito; Keiko Maekawa; Mayumi Saeki; Naoyuki Kamatani; Hiroshi Kajio; Nobuaki Kuzuya; Kazuki Yasuda; Jun-ichi Sawada
Novel genetic variations and haplotypes of hepatocyte nuclear factor 4alpha (HNF4A) found in Japanese type II diabetic patients.
Drug metabolism and pharmacokinetics 2006;21(4):337-46.
2006: Yukiko Nakajima; Takashi Yoshitani; Hiromi Fukushima-Uesaka; Yoshiro Saito; Nahoko Kaniwa; Kouichi Kurose; Shogo Ozawa; Nobuo Aoyagi; Naoyuki Kamatani; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Tomohide Tamura; Teruhiko Yoshida; Hironobu Minami; Nagahiro Saijo; Noriko Katori; Jun-ichi Sawada
Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer.
Clinical pharmacology and therapeutics 2006;80(2):179-91.
2006: Keiko Maekawa; Hiromi Fukushima-Uesaka; Masahiro Tohkin; Ryuichi Hasegawa; Hiroshi Kajio; Nobuaki Kuzuya; Kazuki Yasuda; Manabu Kawamoto; Naoyuki Kamatani; Kazuko Suzuki; Tatsuo Yanagawa; Yoshiro Saito; Jun-ichi Sawada
Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese.
Pharmacogenetics and genomics 2006;16(7):497-514.
2006: Su-Ryang Kim; Yoshiro Saito; Keiko Maekawa; Emiko Sugiyama; Nahoko Kaniwa; Hideki Ueno; Takuji Okusaka; Chigusa Morizane; Noboru Yamamoto; Masafumi Ikeda; Teruhiko Yoshida; Hironobu Minami; Junji Furuse; Hiroshi Ishii; Nagahiro Saijo; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleoside transporter 1 (hENT1).
Drug metabolism and pharmacokinetics 2006;21(3):248-56.
2006: Akiko Soyama; Yoshiro Saito; Takashi Kubo; Atsuko Miyajima; Yasuo Ohno; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Shogo Ozawa; Jun-ichi Sawada
Sequence-based analysis of the CYP2D6*36-CYP2D6*10 tandem-type arrangement, a major CYP2D6*10 haplotype in the Japanese population.
Drug metabolism and pharmacokinetics 2006;21(3):208-16.
2006: Nobumitsu Hanioka; Yoshihito Okumura; Yoshiro Saito; Hiroyuki Hichiya; Akiko Soyama; Keita Saito; Kazuyuki Ueno; Jun-ichi Sawada; Shizuo Narimatsu
Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: in vitro functional analysis of recombinant proteins expressed in Saccharomyces cerevisiae.
Biochemical pharmacology 2006;71(9):1386-95.
2006: Keiko Maekawa; Masaya Itoda; Kimie Sai; Yoshiro Saito; Nahoko Kaniwa; Kuniaki Shirao; Tetsuya Hamaguchi; Hideo Kunitoh; Noboru Yamamoto; Tomohide Tamura; Hironobu Minami; Kaoru Kubota; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population.
Drug metabolism and pharmacokinetics 2006;21(2):109-21.
2006: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Kimie Sai; Shogo Ozawa; Kouichi Kurose; Nahoko Kaniwa; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kuniaki Shirao; Toru Tamura; Noboru Yamamoto; Hideo Kunitoh; Tetsuya Hamaguchi; Teruhiko Yoshida; Kaoru Kubota; Atsushi Ohtsu; M Muto; Hironobu Minami; Nagahiro Saijo; Naoyuki Kamatani; Jun-ichi Sawada
Haplotype structures of the UGT1A gene complex in a Japanese population.
The pharmacogenomics journal 2006;6(1):63-75.
2005: Yoshiro Saito; Nobumitsu Hanioka; Keiko Maekawa; Takashi Isobe; Yumi Tsuneto; Ryosuke Nakamura; Akiko Soyama; Shogo Ozawa; Toshiko Tanaka-Kagawa; Hideto Jinno; Shizuo Narimatsu; Jun-ichi Sawada
Functional analysis of three CYP1A2 variants found in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(12):1905-10.
2005: Takashi Kubo; Su-Ryang Kim; Kimie Sai; Yoshiro Saito; Toshiharu Nakajima; Kenji Matsumoto; Hirohisa Saito; Kuniaki Shirao; Noboru Yamamoto; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Yasuo Ohno; Shogo Ozawa; Jun-ichi Sawada
Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2).
Drug metabolism and disposition: the biological fate of chemicals 2005;33(10):1482-7.
2005: Shinobu Ikeda; Kouichi Kurose; Hideto Jinno; Kimie Sai; Shogo Ozawa; Ryuichi Hasegawa; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Tomohide Tamura; Noboru Yamamoto; Hideo Kunitoh; Yasuhide Yamada; Yuichiro Ohe; Yasuhiro Shimada; Kuniaki Shirao; Kaoru Kubota; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Yoshiro Saito; Jun-ichi Sawada
Functional analysis of four naturally occurring variants of human constitutive androstane receptor.
Molecular genetics and metabolism 2005;86(1-2):314-9.
2005: Hiromi Fukushima-Uesaka; Yoshiro Saito; Keiko Maekawa; Shogo Ozawa; Ryuichi Hasegawa; Hiroshi Kajio; Nobuaki Kuzuya; Kazuki Yasuda; Manabu Kawamoto; Naoyuki Kamatani; Kazuko Suzuki; Tatsuo Yanagawa; Masahiro Tohkin; Jun-ichi Sawada
Genetic variations and haplotypes of CYP2C19 in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(4):300-7.
2005: Satoru Koyano; Yoshiro Saito; Hiromi Fukushima-Uesaka; Seiichi Ishida; Shogo Ozawa; Naoyuki Kamatani; Hironobu Minami; Atsushi Ohtsu; Tetsuya Hamaguchi; Kuniaki Shirao; Teruhiko Yoshida; Nagahiro Saijo; Hideto Jinno; Jun-ichi Sawada
Functional analysis of six human aryl hydrocarbon receptor variants in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1254-60.
2005: K Maekawa; Yoshiro Saito; Shogo Ozawa; S Adachi-Akahane; M Kawamoto; Kazuo Komamura; W Shimizu; K Ueno; Shiro Kamakura; Naoyuki Kamatani; Masafumi Kitakaze; Jun-ichi Sawada
Genetic polymorphisms and haplotypes of the human cardiac sodium channel alpha subunit gene (SCN5A) in Japanese and their association with arrhythmia.
Annals of human genetics 2005;69(Pt 4):413-28.
2005: Ryosuke Nakamura; Haruyo Okunuki; Seiichi Ishida; Yoshiro Saito; Reiko Teshima; Jun-ichi Sawada
Gene expression profiling of dexamethasone-treated RBL-2H3 cells: induction of anti-inflammatory molecules.
Immunology letters 2005;98(2):272-9.
2005: Hiroyuki Hichiya; Toshiko Tanaka-Kagawa; Akiko Soyama; Hideto Jinno; Satoru Koyano; Noriko Katori; Erika Matsushima; Shigehisa Uchiyama; Hiroshi Tokunaga; Hideo Kimura; Narihiro Minami; Masaaki Katoh; Kenji Sugai; Yu-ichi Goto; Tomohide Tamura; Noboru Yamamoto; Yuichiro Ohe; Hideo Kunitoh; Hiroshi Nokihara; Teruhiko Yoshida; Hironobu Minami; Nagahiro Saijo; Masanori Ando; Shogo Ozawa; Yoshiro Saito; Jun-ichi Sawada
Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(5):630-6.
2005: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Kimie Sai; Akiko Hachisuka; Nahoko Kaniwa; Shogo Ozawa; Manabu Kawamoto; Naoyuki Kamatani; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Jun-ichi Sawada
Genetic variations and haplotypes of UGT1A4 in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(2):144-51.
2005: Kan Yonemori; Hideki Ueno; Takuji Okusaka; Noboru Yamamoto; Masafumi Ikeda; Nagahiro Saijo; Teruhiko Yoshida; Hiroshi Ishii; Junji Furuse; Emiko Sugiyama; Su-Ryang Kim; Ruri Kikura-Hanajiri; Ryuichi Hasegawa; Yoshiro Saito; Shogo Ozawa; Nahoko Kaniwa; Jun-ichi Sawada
Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2620-4.
2005: Yukiko Nakajima; Yoshiro Saito; Kisho Shiseki; Hiromi Fukushima-Uesaka; Ryuichi Hasegawa; Shogo Ozawa; Kenji Sugai; Masaaki Katoh; Osamu Saitoh; Teiichi Ohnuma; Mitsuru Kawai; Taisuke Ohtsuki; Chieko Suzuki; Narihiro Minami; Hideo Kimura; Yu-ichi Goto; Naoyuki Kamatani; Nahoko Kaniwa; Jun-ichi Sawada
Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients.
European journal of clinical pharmacology 2005;61(1):25-34.
2005: Nahoko Kaniwa; Kouichi Kurose; Hideto Jinno; Toshiko Tanaka-Kagawa; Yoshiro Saito; Mayumi Saeki; Jun-ichi Sawada; Masahiro Tohkin; Ryuichi Hasegawa
Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel single nucleotide polymorphism 686C> T (P229L) found in an African-American.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(3):458-65.
2005: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Kimie Sai; Nahoko Kaniwa; Shogo Ozawa; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Naoyuki Kamatani; Jun-ichi Sawada
Genetic polymorphisms of UGT1A6 in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(1):85-90.
2005: Satoru Koyano; Yoshiro Saito; Kimie Sai; Kouichi Kurose; Shogo Ozawa; Toshiharu Nakajima; Kenji Matsumoto; Hirohisa Saito; Kuniaki Shirao; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Nagahiro Saijo; Jun-ichi Sawada
Novel genetic polymorphisms in the NR3C1 (glucocorticoid receptor) gene in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(1):79-84.
2005: Akiko Soyama; Yoshiro Saito; Nobumitsu Hanioka; Keiko Maekawa; Kazuo Komamura; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kazuyuki Ueno; Yu-ichi Goto; Hideo Kimura; Masaaki Katoh; Kenji Sugai; Osamu Saitoh; Mitsuru Kawai; Teiichi Ohnuma; Taisuke Ohtsuki; Chieko Suzuki; Narihiro Minami; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(1):24-33.
2005: Hideto Jinno; Nobumitsu Hanioka; Toshiko Tanaka-Kagawa; Yoshiro Saito; Shogo Ozawa; Jun-ichi Sawada
Transfection assays with allele-specific constructs: functional analysis of UDP-glucuronosyltransferase variants.
Methods in molecular biology (Clifton, N.J.) 2005;311():19-29.
2004: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Toshiko Tanaka-Kagawa; Akiko Ohno; Shogo Ozawa; Kazuyuki Ueno; Shiro Kamakura; Naoyuki Kamatani; Kazuo Komamura; Masafumi Kitakaze; Jun-ichi Sawada
Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(9):1048-54.
2004: Hiromi Fukushima-Uesaka; Kimie Sai; Keiko Maekawa; Satoru Koyano; Nahoko Kaniwa; Shogo Ozawa; Manabu Kawamoto; Naoyuki Kamatani; Kazuo Komamura; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kazuyuki Ueno; Hironobu Minami; Atsushi Ohtsu; Kuniaki Shirao; Teruhiko Yoshida; Nagahiro Saijo; Yoshiro Saito; Jun-ichi Sawada
Genetic variations of the AHR gene encoding aryl hydrocarbon receptor in a Japanese population.
Drug metabolism and pharmacokinetics 2004;19(4):320-6.
2004: Akiko Soyama; Takashi Kubo; Atsuko Miyajima; Yoshiro Saito; Kisho Shiseki; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Shogo Ozawa; Jun-ichi Sawada
Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene.
Drug metabolism and pharmacokinetics 2004;19(4):313-9.
2004: Masaya Itoda; Yoshiro Saito; Keiko Maekawa; Hiroyuki Hichiya; Kazuo Komamura; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kazuyuki Ueno; Shogo Ozawa; Jun-ichi Sawada
Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1).
Drug metabolism and pharmacokinetics 2004;19(4):308-12.
2004: Hiromi Fukushima-Uesaka; Keiko Maekawa; Shogo Ozawa; Kazuo Komamura; Kazuyuki Ueno; Masahiko Shibakawa; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Yoshiro Saito; Jun-ichi Sawada
Fourteen novel single nucleotide polymorphisms in the SLC22A2 gene encoding human organic cation transporter (OCT2).
Drug metabolism and pharmacokinetics 2004;19(3):239-44.
2004: Kimie Sai; Mayumi Saeki; Yoshiro Saito; Shogo Ozawa; Noriko Katori; Hideto Jinno; Ryuichi Hasegawa; Nahoko Kaniwa; Jun-ichi Sawada; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Yutaka Kitamura; Naoyuki Kamatani; Hironobu Minami; Atsushi Ohtsu; Kuniaki Shirao; Teruhiko Yoshida; Nagahiro Saijo
UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer.
Clinical pharmacology and therapeutics 2004;75(6):501-15.
2004: Shogo Ozawa; Akiko Soyama; Mayumi Saeki; Hiromi Fukushima-Uesaka; Masaya Itoda; Satoru Koyano; Kimie Sai; Yasuo Ohno; Yoshiro Saito; Jun-ichi Sawada
Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1.
Drug metabolism and pharmacokinetics 2004;19(2):83-95.
2004: Hideto Jinno; Toshiko Tanaka-Kagawa; Nobumitsu Hanioka; Seiich Ishida; Mayumi Saeki; Akiko Soyama; Masaya Itoda; Tetsuji Nishimura; Yoshiro Saito; Shogo Ozawa; Masanori Ando; Jun-ichi Sawada
Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver.
Molecular pharmacology 2004;65(3):496-502.
2004: Akiko Ohno; Yoshiro Saito; Nobumitsu Hanioka; Hideto Jinno; Mayumi Saeki; Masanori Ando; Shogo Ozawa; Jun-ichi Sawada
Involvement of human hepatic UGT1A1, UGT2B4, and UGT2B7 in the glucuronidation of carvedilol.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(2):235-9.
2004: Satoru Koyano; Kouichi Kurose; Yoshiro Saito; Shogo Ozawa; Ryuichi Hasegawa; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Toshiharu Nakajima; Kenji Matsumoto; Akira Akasawa; Hirohisa Saito; Jun-ichi Sawada
Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(1):149-54.
2004: Norie Murayama; Akiko Soyama; Yoshiro Saito; Yukiko Nakajima; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Hideo Kimura; Yu-ichi Goto; Osamu Saitoh; Masaaki Katoh; Teiichi Ohnuma; Mitsuru Kawai; Kenji Sugai; Taisuke Ohtsuki; Chieko Suzuki; Narihiro Minami; Shogo Ozawa; Jun-ichi Sawada
Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes.
The Journal of pharmacology and experimental therapeutics 2004;308(1):300-6.
2003: Kimie Sai; Nahoko Kaniwa; Masaya Itoda; Yoshiro Saito; Ryuichi Hasegawa; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Yutaka Kitamura; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan.
Pharmacogenetics 2003;13(12):741-57.
2003: Satoru Koyano; Yoshiro Saito; Michiyo Nagano; Keiko Maekawa; Yutaka Kikuchi; Norie Murayama; Tomofumi Fujino; Shogo Ozawa; Toshiharu Nakajima; Kenji Matsumoto; Hirohisa Saito; Jun-ichi Sawada
Functional analysis of three genetic polymorphisms in the glucocorticoid receptor gene.
The Journal of pharmacology and experimental therapeutics 2003;307(1):110-6.
2003: Hideto Jinno; Mayumi Saeki; Yoshiro Saito; Toshiko Tanaka-Kagawa; Nobumitsu Hanioka; Kimie Sai; Nahoko Kaniwa; Masanori Ando; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Shogo Ozawa; Jun-ichi Sawada
Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients.
The Journal of pharmacology and experimental therapeutics 2003;306(2):688-93.
2003: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Masahiro Tohkin; Kouichi Kurose; Nahoko Kaniwa; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Shogo Ozawa; Jun-ichi Sawada
Comprehensive UGT1A1 genotyping in a Japanese population by pyrosequencing.
Clinical chemistry 2003;49(7):1182-5.
2003: Mayumi Saeki; Yoshiro Saito; Takahiro Nakamura; Norie Murayama; Su-Ryang Kim; Shogo Ozawa; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Toshiharu Nakajima; Hirohisa Saito; Yutaka Kitamura; Naoyuki Kamatani; Jun-ichi Sawada
Single nucleotide polymorphisms and haplotype frequencies of CYP3A5 in a Japanese population.
Human mutation 2003;21(6):653.
2003: Hideto Jinno; Mayumi Saeki; Toshiko Tanaka-Kagawa; Nobumitsu Hanioka; Yoshiro Saito; Shogo Ozawa; Masanori Ando; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Jun-ichi Sawada
Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(5):528-32.
2003: Keiko Maekawa; Masaya Itoda; Nobumitsu Hanioka; Yoshiro Saito; Norie Murayama; Osamu Nakajima; Akiko Soyama; Seiichi Ishida; Shogo Ozawa; Masanori Ando; Jun-ichi Sawada
Non-synonymous single nucleotide alterations in the microsomal epoxide hydrolase gene and their functional effects.
Xenobiotica; the fate of foreign compounds in biological systems 2003;33(3):277-87.
2003: Michiyo Nagano; Takahiro Nakamura; Shogo Ozawa; Keiko Maekawa; Yoshiro Saito; Jun-ichi Sawada
Allele-specific long-range PCR/sequencing method for allelic assignment of multiple single nucleotide polymorphisms.
Journal of biochemical and biophysical methods 2003;55(1):1-9.
2003: Shinobu Ikeda; Kouichi Kurose; Shogo Ozawa; Kimie Sai; Ryuichi Hasegawa; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Toshiharu Nakajima; Kenji Matsumoto; Hirohisa Saito; Yu-Ichi Goto; Hideo Kimura; Masaaki Katoh; Kenji Sugai; Narihiro Minami; Kuniaki Shirao; Tomohide Tamura; Noboru Yamamoto; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Yoshiro Saito; Jun-ichi Sawada
Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population.
Drug metabolism and pharmacokinetics 2003;18(6):413-8.
2003: Su-Ryang Kim; Takahiro Nakamura; Yoshiro Saito; Kimie Sai; Toshiharu Nakajima; Hirohisa Saito; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Shogo Ozawa; Jun-ichi Sawada
Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2).
Drug metabolism and pharmacokinetics 2003;18(5):327-32.
2003: Masaya Itoda; Yoshiro Saito; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Hiroshi Suzuki; Yuichi Sugiyama; Shogo Ozawa; Jun-ichi Sawada
Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.
Drug metabolism and pharmacokinetics 2003;18(3):212-7.
2003: Kisho Shiseki; Masaya Itoda; Yoshiro Saito; Yukiko Nakajima; Keiko Maekawa; Hideo Kimura; Yu-ichi Goto; Osamu Saitoh; Masaaki Katoh; Teiichi Ohnuma; Mitsuru Kawai; Kenji Sugai; Taisuke Ohtsuki; Chieko Suzuki; Narihiro Minami; Shogo Ozawa; Jun-ichi Sawada
Five novel single nucleotide polymorphisms in the EPHX1 gene encoding microsomal epoxide hydrolase.
Drug metabolism and pharmacokinetics 2003;18(2):150-3.
2003: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Kimie Sai; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Shogo Ozawa; Jun-ichi Sawada
Three novel single nucleotide polymorphisms in UGT1A9.
Drug metabolism and pharmacokinetics 2003;18(2):146-9.
2003: Hideto Jinno; Toshiko Tanaka-Kagawa; Nobumitsu Hanioka; Mayumi Saeki; Seiichi Ishida; Tetsuji Nishimura; Masanori Ando; Yoshiro Saito; Shogo Ozawa; Jun-ichi Sawada
Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(1):108-13.
2002: Schuichi Koizumi; Yoshiro Saito; Ken Nakazawa; Kazuyuki Nakajima; Jun Ichi Sawada; Shinichi Kohsaka; Peter Illes; Kazuhide Inoue
Spatial and temporal aspects of Ca2+ signaling mediated by P2Y receptors in cultured rat hippocampal astrocytes.
Life sciences 2002;72(4-5):431-42.
2002: Ryosuke Nakamura; Seiichi Ishida; Shogo Ozawa; Yoshiro Saito; Haruyo Okunuki; Reiko Teshima; Jun-ichi Sawada
Gene expression profiling of Ca2+-atpase inhibitor DTBHQ and antigen-stimulated RBL-2H3 mast cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51(12):611-8.
2002: Akiko Soyama; Nobumitsu Hanioka; Yoshiro Saito; Norie Murayama; Masanori Ando; Shogo Ozawa; Jun-ichi Sawada
Amiodarone N-deethylation by CYP2C8 and its variants, CYP2C8*3 and CYP2C8 P404A.
Pharmacology & toxicology 2002;91(4):174-8.
2002: Michiyo Nagano; Takahiro Nakamura; Shingo Niimi; Tomofumi Fujino; Tetsuji Nishimura; Norie Murayama; Seiichi Ishida; Shogo Ozawa; Yoshiro Saito; Jun-ichi Sawada
Substitution of arginine for cysteine 643 of the glucocorticoid receptor reduces its steroid-binding affinity and transcriptional activity.
Cancer letters 2002;181(1):109-14.
2002: Nobumitsu Hanioka; Yoshiro Saito; Akiko Soyama; Masanori Ando; Shogo Ozawa; Jun-ichi Sawada
High-performance liquid chromatographic assay for amiodarone N-deethylation activity in human liver microsomes using solid-phase extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;774(1):105-13.
2002: Mayumi Saeki; Yoshiro Saito; Michiyo Nagano; Reiko Teshima; Shogo Ozawa; Jun-ichi Sawada
mRNA expression of multiple cytochrome p450 isozymes in four types of cultured skin cells.
International archives of allergy and immunology 2002;127(4):333-6.
2002: Masaya Itoda; Yoshiro Saito; Akiko Soyama; Mayumi Saeki; Norie Murayama; Seiichi Ishida; Kimie Sai; Michiyo Nagano; Hiroshi Suzuki; Yuichi Sugiyama; Shogo Ozawa; Jun-ichi Sawada Ji
Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: an association between single nucleotide polymorphisms in the 5'-untranslated region and exon 28.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(4):363-4.
2002: Masaya Itoda; Yoshiro Saito; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Shogo Ozawa; Jun-ichi Sawada
Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone.
Drug metabolism and pharmacokinetics 2002;17(6):566-71.
2002: Satoru Koyano; Kouichi Kurose; Shogo Ozawa; Mayumi Saeki; Yukiko Nakajima; Ryuichi Hasegawa; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Toshiharu Nakajima; Hirohisa Saito; Hideo Kimura; Yu-ichi Goto; Osamu Saitoh; Masaaki Katoh; Teiichi Ohnuma; Mitsuru Kawai; Kenji Sugai; Taisuke Ohtsuki; Chieko Suzuki; Narihiro Minami; Yoshiro Saito; Jun-ichi Sawada
Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations.
Drug metabolism and pharmacokinetics 2002;17(6):561-5.
2002: Mayumi Saeki; Shogo Ozawa; Yoshiro Saito; Hideto Jinno; Tetsuya Hamaguchi; Hiroshi Nokihara; Yasuhiro Shimada; Hideo Kunitoh; Noboru Yamamoto; Yuichiro Ohe; Yasuhide Yamada; Kuniaki Shirao; Manabu Muto; Kiyomi Mera; Koichi Goto; Hironobu Ohmatsu; Kaoru Kubota; Seiji Niho; Ryutaro Kakinuma; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Jun-ichi Sawada
Three novel single nucleotide polymorphisms in UGT1A10.
Drug metabolism and pharmacokinetics 2002;17(5):488-90.
2002: Akiko Soyama; Yoshiro Saito; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Shogo Ozawa; Jun-ichi Sawada
Novel single nucleotide polymorphisms in the CYP2D6 gene associated with CYP2D6*2 and/or CYP2D6*10 alleles.
Drug metabolism and pharmacokinetics 2002;17(5):475-8.
2002: Akiko Soyama; Yoshiro Saito; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Shogo Ozawa; Jun-ichi Sawada
Five novel single nucleotide polymorphisms in the CYP2C8 gene, one of which induces a frame-shift.
Drug metabolism and pharmacokinetics 2002;17(4):374-7.
2002: Seiichi Ishida; Akiko Soyama; Yoshiro Saito; Norie Murayama; Mayumi Saeki; Kimie Sai; Shogo Ozawa; Jun-ichi Sawada
Determination of CYP2D6 gene alleles by the CYP450 probe array using the Affymetrix GeneChip system: comparison with sequencing results.
Drug metabolism and pharmacokinetics 2002;17(2):157-60.
2002: Norie Murayama; Takahiro Nakamura; Mayumi Saeki; Akiko Soyama; Yoshiro Saito; Kimie Sai; Seiichi Ishida; Osamu Nakajima; Masaya Itoda; Yasuo Ohno; Shogo Ozawa; Jun-ichi Sawada
CYP3A4 gene polymorphisms influence testosterone 6beta-hydroxylation.
Drug metabolism and pharmacokinetics 2002;17(2):150-6.
2001: Akiko Soyama; Yoshiro Saito; Nobumitsu Hanioka; Norie Murayama; Osamu Nakajima; Noriko Katori; Seiichi Ishida; Kimie Sai; Shogo Ozawa; Jun-ichi Sawada
Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism.
Biological & pharmaceutical bulletin 2001;24(12):1427-30.
2001: Nobumitsu Hanioka; Shogo Ozawa; Hideto Jinno; Masanori Ando; Yoshiro Saito; Jun-ichi Sawada
Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin.
Xenobiotica; the fate of foreign compounds in biological systems 2001;31(10):687-99.
2001: Kayoko Takagi; Yoshiro Saito; Jun-ichi Sawada
Proteasome inhibitor enhances growth hormone-binding protein release.
Molecular and cellular endocrinology 2001;182(2):157-63.
2001: T Nakamura; Yoshiro Saito; Norie Murayama; M Saeki; Akiko Soyama; Kimie Sai; Shogo Ozawa; Jun-ichi Sawada
Apparent low frequency of sequence variability within the proximal promoter region of the cytochrome P450 (CYP) 3A5 gene in established cell lines from Japanese individuals.
Biological & pharmaceutical bulletin 2001;24(8):954-7.
2001: Kayoko Takagi; Yoshiro Saito; Jun-ichi Sawada
Proteasomes are involved in the constitutive degradation of growth hormone receptors.
Biological & pharmaceutical bulletin 2001;24(7):744-8.
1999: Kayoko Takagi; Yoshiro Saito; Osamu Nakajima; Jun-ichi Sawada
Characterization of an antagonist monoclonal antibody, GHBP116, specific for human growth hormone receptors.
Biological & pharmaceutical bulletin 1999;22(7):734-7.
1999: Yoshiro Saito; Kayoko Takagi; Reiko Teshima; H Ikebuchi; T Yamazaki; Jun-ichi Sawada
Role of ecto-kinase in phorbol ester-enhanced growth hormone-binding protein release from human IM-9 cells.
Molecular and cellular endocrinology 1999;152(1-2):65-72.
1999: Reiko Teshima; Jun-ichi Onose; Yoshiro Saito; H Ikebuchi; Seiichi Kitani; Jun-ichi Sawada
Casein kinase II-like ectokinase activity on RBL-2H3 cells.
Immunology letters 1999;68(2-3):369-74.
1998: Yoshiro Saito; Reiko Teshima; Kayoko Takagi; H Ikebuchi; T Yamazaki; Jun-ichi Sawada
Activation of protein kinase C alpha enhances human growth hormone-binding protein release.
Molecular and cellular endocrinology 1998;146(1-2):197-205.
1997: Reiko Teshima; Yoshiro Saito; H Ikebuchi; N Rajiva De Silva; Y Morita; M Nakanishi; Jun-ichi Sawada; Seiichi Kitani
Effect of an ectokinase inhibitor, K252b, on degranulation and Ca2+ signals of RBL-2H3 cells and human basophils.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):964-9.
1994: Yoshiro Saito; R Teshima; T Yamazaki; H Ikebuchi; Jun-ichi Sawada
Ligand-induced internalization and phosphorylation-dependent degradation of growth hormone receptor in human IM-9 cells.
Molecular and cellular endocrinology 1994;106(1-2):67-74.
1994: M Kawasaki; Masatake Toyoda; R Teshima; Jun-ichi Sawada; Yoshiro Saito
Effect of alpha-linolenic acid on the metabolism of omega-3 and omega-6 polyunsaturated fatty acids and histamine release in RBL-2H3 cells.
Biological & pharmaceutical bulletin 1994;17(10):1321-5.
1994: Y Ozaki; A Ohno; Yoshiro Saito; Motoyoshi Satake
Accelerative effect of shikonin, alkannin and acetylshikonin on the proliferation of granulation tissue in rats.
Biological & pharmaceutical bulletin 1994;17(8):1075-7.
1994: Yoshiro Saito; T Yamazaki; Kazuhiro Suzuki; H Ikebuchi; A Asakura; Y Ota; Jun-ichi Sawada; T Terao
Preparation of monoclonal antibodies for immunoblotting human growth hormone receptor and growth hormone-binding protein.
Biological & pharmaceutical bulletin 1994;17(7):983-6.
1990: Kazuhiro Suzuki; S Suzuki; Yoshiro Saito; H Ikebuchi; T Terao
Human growth hormone-stimulated growth of human cultured lymphocytes (IM-9) and its inhibition by phorbol diesters through down-regulation of the hormone receptors. Possible involvement of phosphorylation of a 55,000 molecular weight protein associated with the receptor in the down-regulation.
The Journal of biological chemistry 1990;265(19):11320-7.