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Masao Saitoh

Research Profile

Chemicals & Drugs

Physiology

Anatomy

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Publications

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K Horiguchi; A Inoue; S Inoue; D Koinuma; Keiji Miyazawa; Kohei Miyazono; K Sakamoto; Kentaro Semba; A Yamaguchi; H Fujii; Masao Saitoh
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.
Kana Horiguchi; Masao Saitoh
[Encounter of cancer cells with bone. Epithelial-mesenchymal transition in cancer].
Takuya Shirakihara; Kana Horiguchi; Keiji Miyazawa; Shogo Ehata; Tatsuhiro Shibata; Ikuo Morita; Kohei Miyazono; Masao Saitoh
TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition.

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All Publications

2012: K Horiguchi; A Inoue; S Inoue; D Koinuma; Keiji Miyazawa; Kohei Miyazono; K Sakamoto; Kentaro Semba; A Yamaguchi; H Fujii; Masao Saitoh
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.
Oncogene 2012;31(26):3190-201.
2011: Kana Horiguchi; Masao Saitoh
[Encounter of cancer cells with bone. Epithelial-mesenchymal transition in cancer].
Clinical calcium 2011;21(3):405-10.
2011: Takuya Shirakihara; Kana Horiguchi; Keiji Miyazawa; Shogo Ehata; Tatsuhiro Shibata; Ikuo Morita; Kohei Miyazono; Masao Saitoh
TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition.
The EMBO journal 2011;30(4):783-95.
2010: Anna Mizutani; Masao Saitoh; Takeshi Imamura; Keiji Miyazawa; Kohei Miyazono
Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling.
Journal of biochemistry 2010;148(6):733-41.
2010: Motoko Nagata; Shinji Nagata; Keiko Yuki; Kazunobu Isogaya; Masao Saitoh; Kohei Miyazono; Keiji Miyazawa
Identification of a phosphorylation site in c-Ski as serine 515.
Journal of biochemistry 2010;148(4):423-7.
2009: Masao Saitoh; Takuya Shirakihara; Kohei Miyazono
Regulation of the stability of cell surface E-cadherin by the proteasome.
Biochemical and biophysical research communications 2009;381(4):560-5.
2009: Roy-Akira Saito; Tetsuro Watabe; Kana Horiguchi; Tadashi Kohyama; Masao Saitoh; Takahide Nagase; Kohei Miyazono
Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells.
Cancer research 2009;69(7):2783-91.
2009: Kana Horiguchi; Takuya Shirakihara; Ayako Nakano; Takeshi Imamura; Kohei Miyazono; Masao Saitoh
Role of Ras signaling in the induction of snail by transforming growth factor-beta.
The Journal of biological chemistry 2009;284(1):245-53.
2007: Go Fujino; Takuya Noguchi; Atsushi Matsuzawa; Shota Yamauchi; Masao Saitoh; Kohsuke Takeda; Hidenori Ichijo
Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1.
Molecular and cellular biology 2007;27(23):8152-63.
2007: Shogo Ehata; Aki Hanyu; Makoto Hayashi; Hiroyuki Aburatani; Yukio Kato; Makoto Fujime; Masao Saitoh; Keiji Miyazawa; Takeshi Imamura; Kohei Miyazono
Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1.
Cancer research 2007;67(20):9694-703.
2007: Takuya Shirakihara; Masao Saitoh; Kohei Miyazono
Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta.
Molecular biology of the cell 2007;18(9):3533-44.
2007: Yoshiko Nagano; Konstantinos J Mavrakis; Kian Leong Lee; Tomoko Fujii; Daizo Koinuma; Hitoshi Sase; Keiko Yuki; Kazunobu Isogaya; Masao Saitoh; Takeshi Imamura; Vasso Episkopou; Kohei Miyazono; Keiji Miyazawa
Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling.
The Journal of biological chemistry 2007;282(28):20492-501.
2007: Kohsuke Takeda; Rieko Shimozono; Takuya Noguchi; Tsuyoshi Umeda; Yoshifumi Morimoto; Isao Naguro; Kei Tobiume; Masao Saitoh; Atsushi Matsuzawa; Hidenori Ichijo
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
The Journal of biological chemistry 2007;282(10):7522-31.
2007: Norihiko Kobayashi; Kouichiro Goto; Kana Horiguchi; Motoko Nagata; Mikiko Kawata; Keiji Miyazawa; Masao Saitoh; Kohei Miyazono
c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(3):375-85.
2006: Motoko Nagata; Kouichiro Goto; Shogo Ehata; Norihiko Kobayashi; Masao Saitoh; Hiroyuki Miyoshi; Takeshi Imamura; Keiji Miyazawa; Kohei Miyazono
Nuclear and cytoplasmic c-Ski differently modulate cellular functions.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(11):1267-80.
2006: N Fukuda; Masao Saitoh; Noriko Kobayashi; Kohei Miyazono
Execution of BMP-4-induced apoptosis by p53-dependent ER dysfunction in myeloma and B-cell hybridoma cells.
Oncogene 2006;25(25):3509-17.
2005: Masayoshi Tojo; Yoshio Hamashima; Aki Hanyu; Tetsuya Kajimoto; Masao Saitoh; Kohei Miyazono; Manabu Node; Takeshi Imamura
The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta.
Cancer science 2005;96(11):791-800.
2004: Miki Kondo; E Cubillo; Kei Tobiume; T Shirakihara; N Fukuda; H Suzuki; Kiyoshi Shimizu; K Takehara; A Cano; Masao Saitoh; Kohei Miyazono
A role for Id in the regulation of TGF-beta-induced epithelial-mesenchymal transdifferentiation.
Cell death and differentiation 2004;11(10):1092-101.
2004: Akiyoshi Komuro; Takeshi Imamura; Masao Saitoh; Yoko Yoshida; Takao Yamori; Kohei Miyazono; Keiji Miyazawa
Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).
Oncogene 2004;23(41):6914-23.
2003: Daizo Koinuma; Masahiko Shinozaki; Akiyoshi Komuro; Kouichiro Goto; Masao Saitoh; Aki Hanyu; Masahito Ebina; Toshihiro Nukiwa; Keiji Miyazawa; Takeshi Imamura; Kohei Miyazono
Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7.
The EMBO journal 2003;22(24):6458-70.
2003: Shigeo Matsuyama; Manabu Iwadate; Miki Kondo; Masao Saitoh; Aki Hanyu; Kiyoshi Shimizu; Hiroyuki Aburatani; Hiromu K Mishima; Takeshi Imamura; Kohei Miyazono; Keiji Miyazawa
SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.
Cancer research 2003;63(22):7791-8.
2002: Kei Tobiume; Masao Saitoh; Hidenori Ichijo
Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer.
Journal of cellular physiology 2002;191(1):95-104.
2001: K Morita; Masao Saitoh; Kei Tobiume; H Matsuura; S Enomoto; Hideki Nishitoh; Hidenori Ichijo
Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.
The EMBO journal 2001;20(21):6028-36.
2001: Y Sawada; K Nakamura; K Doi; Kiyoshi Takeda; Kei Tobiume; Masao Saitoh; K Morita; I Komuro; K De Vos; M Sheetz; Hidenori Ichijo
Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase.
Journal of cell science 2001;114(Pt 6):1221-7.
2000: Y Mochida; Kiyoshi Takeda; Masao Saitoh; Hideki Nishitoh; T Amagasa; Jun Ninomiya-Tsuji; K Matsumoto; Hidenori Ichijo
ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction.
The Journal of biological chemistry 2000;275(42):32747-52.
1998: Hideki Nishitoh; Masao Saitoh; Y Mochida; Kiyoshi Takeda; H Nakano; M Rothe; Kohei Miyazono; Hidenori Ichijo
ASK1 is essential for JNK/SAPK activation by TRAF2.
Molecular cell 1998;2(3):389-95.
1998: Kiyoshi Takeda; Hidenori Ichijo; M Fujii; Y Mochida; Masao Saitoh; Hideki Nishitoh; TK Sampath; Kohei Miyazono
Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.
The Journal of biological chemistry 1998;273(27):17079-85.
1998: Masao Saitoh; Hideki Nishitoh; M Fujii; Kiyoshi Takeda; Kei Tobiume; Y Sawada; M Kawabata; Kohei Miyazono; Hidenori Ichijo
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.
The EMBO journal 1998;17(9):2596-606.
1997: Hidenori Ichijo; E Nishida; K Irie; Peter ten Dijke; Masao Saitoh; T Moriguchi; M Takagi; K Matsumoto; Kohei Miyazono; Y Gotoh
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.
Science (New York, N.Y.) 1997;275(5296):90-4.
1996: T Okadome; E Oeda; Masao Saitoh; Hidenori Ichijo; H L Moses; Kohei Miyazono; M Kawabata
Characterization of the interaction of FKBP12 with the transforming growth factor-beta type I receptor in vivo.
The Journal of biological chemistry 1996;271(36):21687-90.
1996: Masao Saitoh; Hideki Nishitoh; T Amagasa; Kohei Miyazono; M Takagi; Hidenori Ichijo
Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta.
The Journal of biological chemistry 1996;271(5):2769-75.