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Shin-ichiroh Saitoh

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Shin-ichiroh Saitoh; Kensuke Miyake
Regulatory molecules required for nucleotide-sensing Toll-like receptors.
Samia Shawkat; Risuke Karima; Tadashi Tojo; Hisashi Tadakuma; Shin-ichiroh Saitoh; Sachiko Akashi-Takamura; Kensuke Miyake; Takashi Funatsu; Kouji Matsushima
Visualization of the molecular dynamics of lipopolysaccharide on the plasma membrane of murine macrophages by total internal reflection fluorescence microscopy.
Fumi Matsumoto; Shin-ichiroh Saitoh; Ryutaroh Fukui; Toshihiko Kobayashi; Natsuko Tanimura; Kazunori Konno; Yutaka Kusumoto; Sachiko Akashi-Takamura; Kensuke Miyake
Cathepsins are required for Toll-like receptor 9 responses.

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All Publications

2009: Shin-ichiroh Saitoh; Kensuke Miyake
Regulatory molecules required for nucleotide-sensing Toll-like receptors.
Immunological reviews 2009;227(1):32-43.
2008: Samia Shawkat; Risuke Karima; Tadashi Tojo; Hisashi Tadakuma; Shin-ichiroh Saitoh; Sachiko Akashi-Takamura; Kensuke Miyake; Takashi Funatsu; Kouji Matsushima
Visualization of the molecular dynamics of lipopolysaccharide on the plasma membrane of murine macrophages by total internal reflection fluorescence microscopy.
The Journal of biological chemistry 2008;283(34):22962-71.
2008: Fumi Matsumoto; Shin-ichiroh Saitoh; Ryutaroh Fukui; Toshihiko Kobayashi; Natsuko Tanimura; Kazunori Konno; Yutaka Kusumoto; Sachiko Akashi-Takamura; Kensuke Miyake
Cathepsins are required for Toll-like receptor 9 responses.
Biochemical and biophysical research communications 2008;367(3):693-9.
2007: Koichiro Takahashi; Takuma Shibata; Sachiko Akashi-Takamura; Takashi Kiyokawa; Yasutaka Wakabayashi; Natsuko Tanimura; Toshihiko Kobayashi; Fumi Matsumoto; Ryutaro Fukui; Taku Kouro; Yoshinori Nagai; Kiyoshi Takatsu; Shin-ichiroh Saitoh; Kensuke Miyake
A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses.
The Journal of experimental medicine 2007;204(12):2963-76.
2006: Naoko Tsuneyoshi; Jun Kohara; Uleng Bahrun; Shin-ichiroh Saitoh; Sachiko Akashi; Jean-François Gauchat; Masao Kimoto; Kenji Fukudome
Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomerization of TLR4 required for signal transduction.
Cellular immunology 2006;244(1):57-64.
2006: Yasutaka Wakabayashi; Makiko Kobayashi; Sachiko Akashi-Takamura; Natsuko Tanimura; Kazunori Konno; Koichiro Takahashi; Takashi Ishii; Taketoshi Mizutani; Hideo Iba; Taku Kouro; Satoshi Takaki; Kiyoshi Takatsu; Yoshiya Oda; Yasushi Ishihama; Shin-ichiroh Saitoh; Kensuke Miyake
A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1772-9.
2006: Makiko Kobayashi; Shin-ichiroh Saitoh; Natsuko Tanimura; Koichiro Takahashi; Kiyoshi Kawasaki; Masahiro Nishijima; Yukari Fujimoto; Koichi Fukase; Sachiko Akashi-Takamura; Kensuke Miyake
Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6211-8.
2006: Sachiko Akashi-Takamura; Takahisa Furuta; Koichiro Takahashi; Natsuko Tanimura; Yutaka Kusumoto; Toshihiko Kobayashi; Shin-ichiroh Saitoh; Yoshiyuki Adachi; Takahiro Doi; Kensuke Miyake
Agonistic antibody to TLR4/MD-2 protects mice from acute lethal hepatitis induced by TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4244-51.
2006: Natsuko Tanimura; Shin-ichiroh Saitoh; Sunao Kawano; Atsushi Kosugi; Kensuke Miyake
Palmitoylation of LAT contributes to its subcellular localization and stability.
Biochemical and biophysical research communications 2006;341(4):1177-83.
2006: Kazunori Konno; Yasutaka Wakabayashi; Sachiko Akashi-Takamura; Takashi Ishii; Makiko Kobayashi; Koichiro Takahashi; Yutaka Kusumoto; Shin-ichiroh Saitoh; Yasuyuki Yoshizawa; Kensuke Miyake
A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression.
Biochemical and biophysical research communications 2006;339(4):1076-82.
2006: Shin-ichiroh Saitoh; Kensuke Miyake
Mechanism regulating cell surface expression and activation of Toll-like receptor 4.
Chemical record (New York, N.Y.) 2006;6(6):311-9.
2005: Yoshinori Nagai; Toshihiko Kobayashi; Yuji Motoi; Kohtaroh Ishiguro; Sachiko Akashi; Shin-ichiroh Saitoh; Yutaka Kusumoto; Tsuneyasu Kaisho; Shizuo Akira; Mitsuru Matsumoto; Kiyoshi Takatsu; Kensuke Miyake
The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7043-9.
2004: Shin-ichiroh Saitoh; Sachiko Akashi; Takenao Yamada; Natsuko Tanimura; Makiko Kobayashi; Kazunori Konno; Fumi Matsumoto; Koichi Fukase; Shoichi Kusumoto; Yoshinori Nagai; Yutaka Kusumoto; Atsushi Kosugi; Kensuke Miyake
Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization.
International immunology 2004;16(7):961-9.
2004: Shin-ichiroh Saitoh; Sachiko Akashi; Takenao Yamada; Natsuko Tanimura; Fumi Matsumoto; Koichi Fukase; Shoichi Kusumoto; Atsushi Kosugi; Kensuke Miyake
Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling.
Journal of endotoxin research 2004;10(4):257-60.
2003: Sachiko Akashi; Shin-ichiroh Saitoh; Yasutaka Wakabayashi; Takane Kikuchi; Noriaki Takamura; Yoshinori Nagai; Yutaka Kusumoto; Koichi Fukase; Shoichi Kusumoto; Yoshiyuki Adachi; Atsushi Kosugi; Kensuke Miyake
Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14.
The Journal of experimental medicine 2003;198(7):1035-42.
2003: Shin-ichiroh Saitoh; Sandra Odom; Gregorio Gomez; Connie L Sommers; Howard A Young; Juan Rivera; Lawrence E Samelson
The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation.
The Journal of experimental medicine 2003;198(5):831-43.
2002: Shin-ichiroh Saitoh; Masakazu Nagafuku; Atsushi Kosugi
[T cell membrane raft domains: its function in T cell activation].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2002;47(16 Suppl):2234-41.
2001: Atsushi Kosugi; Fumie Hayashi; Douglas R Liddicoat; Koubun Yasuda; Shin-ichiroh Saitoh; Toshiyuki Hamaoka
A pivotal role of cysteine 3 of Lck tyrosine kinase for localization to glycolipid-enriched microdomains and T cell activation.
Immunology letters 2001;76(2):133-8.
2000: Koubun Yasuda; Atsushi Kosugi; Fumie Hayashi; Shin-ichiroh Saitoh; Masakazu Nagafuku; Yasuo Mori; Masato Ogata; Toshiyuki Hamaoka
Serine 6 of Lck tyrosine kinase: a critical site for Lck myristoylation, membrane localization, and function in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3226-31.
2000: Shin-ichiroh Saitoh; Ramachandran Arudchandran; Timothy Scott Manetz; W Zhang; Connie L Sommers; Paul E Love; Juan Rivera; Lawrence E Samelson
LAT is essential for Fc(epsilon)RI-mediated mast cell activation.
Immunity 2000;12(5):525-35.
1999: Atsushi Kosugi; Shin-ichiroh Saitoh; S Noda; Koubun Yasuda; Fumie Hayashi; M Ogata; Toshiyuki Hamaoka
Translocation of tyrosine-phosphorylated TCRzeta chain to glycolipid-enriched membrane domains upon T cell activation.
International immunology 1999;11(9):1395-401.