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Noriko Sakaguchi

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Shimon Sakaguchi; Atsushi Tanaka; Satoshi Tanaka; Yoshinaga Ito; Shinji Maeda; Noriko Sakaguchi; Motomu Hashimoto
Thymus, innate immunity and autoimmune arthritis: interplay of gene and environment.
Satoshi Tanaka; Shinji Maeda; Motomu Hashimoto; Chihiro Fujimori; Yoshinaga Ito; Shin Teradaira; Keiji Hirota; Hiroyuki Yoshitomi; Tomoya Katakai; Akira Shimizu; Takashi Nomura; Noriko Sakaguchi; Shimon Sakaguchi
Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function.
Motomu Hashimoto; Keiji Hirota; Hiroyuki Yoshitomi; Shinji Maeda; Shin Teradaira; Shuji Akizuki; Paz Prieto-Martin; Takashi Nomura; Noriko Sakaguchi; Jörg Köhl; Birgitta Heyman; Minoru Takahashi; Teizo Fujita; Tsuneyo Mimori; Shimon Sakaguchi
Complement drives Th17 cell differentiation and triggers autoimmune arthritis.

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2011: Shimon Sakaguchi; Atsushi Tanaka; Satoshi Tanaka; Yoshinaga Ito; Shinji Maeda; Noriko Sakaguchi; Motomu Hashimoto
Thymus, innate immunity and autoimmune arthritis: interplay of gene and environment.
FEBS letters 2011;585(23):3633-9.
2010: Satoshi Tanaka; Shinji Maeda; Motomu Hashimoto; Chihiro Fujimori; Yoshinaga Ito; Shin Teradaira; Keiji Hirota; Hiroyuki Yoshitomi; Tomoya Katakai; Akira Shimizu; Takashi Nomura; Noriko Sakaguchi; Shimon Sakaguchi
Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2295-305.
2010: Motomu Hashimoto; Keiji Hirota; Hiroyuki Yoshitomi; Shinji Maeda; Shin Teradaira; Shuji Akizuki; Paz Prieto-Martin; Takashi Nomura; Noriko Sakaguchi; Jörg Köhl; Birgitta Heyman; Minoru Takahashi; Teizo Fujita; Tsuneyo Mimori; Shimon Sakaguchi
Complement drives Th17 cell differentiation and triggers autoimmune arthritis.
The Journal of experimental medicine 2010;207(6):1135-43.
2009: Yoshinaga Ito; Takashi Usui; Shio Kobayashi; Mikiko Iguchi-Hashimoto; Hiromu Ito; Hiroyuki Yoshitomi; Takashi Nakamura; Masakazu Shimizu; Daisuke Kawabata; Naoichiro Yukawa; Motomu Hashimoto; Noriko Sakaguchi; Shimon Sakaguchi; Hajime Yoshifuji; Takaki Nojima; Koichiro Ohmura; Takao Fujii; Tsuneyo Mimori
Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.
Arthritis and rheumatism 2009;60(8):2294-303.
2007: Keiji Hirota; Hiroyuki Yoshitomi; Motomu Hashimoto; Shinji Maeda; Shin Teradaira; Naoshi Sugimoto; Tomoyuki Yamaguchi; Takashi Nomura; Hiromu Ito; Takashi Nakamura; Noriko Sakaguchi; Shimon Sakaguchi
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.
The Journal of experimental medicine 2007;204(12):2803-12.
2007: Keiji Hirota; Motomu Hashimoto; Hiroyuki Yoshitomi; Satoshi Tanaka; Takashi Nomura; Tomoyuki Yamaguchi; Yoichiro Iwakura; Noriko Sakaguchi; Shimon Sakaguchi
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.
The Journal of experimental medicine 2007;204(1):41-7.
2006: Shimon Sakaguchi; Noriko Sakaguchi; Hiroyuki Yoshitomi; Hiroshi Hata; Takeshi Takahashi; Takashi Nomura
Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1.
Seminars in immunology 2006;18(4):199-206.
2005: Shimon Sakaguchi; Noriko Sakaguchi
Animal models of arthritis caused by systemic alteration of the immune system.
Current opinion in immunology 2005;17(6):589-94.
2005: Shimon Sakaguchi; Noriko Sakaguchi
Regulatory T cells in immunologic self-tolerance and autoimmune disease.
International reviews of immunology 2005;24(3-4):211-26.
2005: Hiroyuki Yoshitomi; Noriko Sakaguchi; Katsuya Kobayashi; Gordon D Brown; Tomoyuki Tagami; Toshiko Sakihama; Keiji Hirota; Satoshi Tanaka; Takashi Nomura; Ichiro Miki; Siamon Gordon; Shizuo Akira; Takashi Nakamura; Shimon Sakaguchi
A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice.
The Journal of experimental medicine 2005;201(6):949-60.
2004: Hiroshi Hata; Noriko Sakaguchi; Hiroyuki Yoshitomi; Yoichiro Iwakura; Kenji Sekikawa; Yoshiaki Azuma; Chieko Kanai; Eiko Moriizumi; Takashi Nomura; Takashi Nakamura; Shimon Sakaguchi
Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice.
The Journal of clinical investigation 2004;114(4):582-8.
2003: Noriko Sakaguchi; Takeshi Takahashi; Hiroshi Hata; Takashi Nomura; Tomoyuki Tagami; Sayuri Yamazaki; Toshiko Sakihama; Takaji Matsutani; Izumi Negishi; Syuichi Nakatsuru; Shimon Sakaguchi
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice.
Nature 2003;426(6965):454-60.
2003: Shimon Sakaguchi; Shohei Hori; Yoshinori Fukui; Takehiko Sasazuki; Noriko Sakaguchi; Takeshi Takahashi
Thymic generation and selection of CD25+CD4+ regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance.
Novartis Foundation symposium 2003;252():6-16; discussion 16-23, 106-14.
2001: Shimon Sakaguchi; Takeshi Takahashi; Sayuri Yamazaki; Y Kuniyasu; M Itoh; Noriko Sakaguchi; Jun Shimizu
Immunologic self tolerance maintained by T-cell-mediated control of self-reactive T cells: implications for autoimmunity and tumor immunity.
Microbes and infection / Institut Pasteur 2001;3(11):911-8.
2001: Shimon Sakaguchi; Noriko Sakaguchi; Jun Shimizu; Sayuri Yamazaki; Toshiko Sakihama; M Itoh; Y Kuniyasu; Takashi Nomura; M Toda; Takeshi Takahashi
Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance.
Immunological reviews 2001;182():18-32.
2000: Takeshi Takahashi; Tomoyuki Tagami; Sayuri Yamazaki; Toshimitsu Uede; Jun Shimizu; Noriko Sakaguchi; T W Mak; Shimon Sakaguchi
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.
The Journal of experimental medicine 2000;192(2):303-10.