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Hideki Sakahira

Research Profile

Chemicals & Drugs

Living Beings

Mouse

Concepts & Ideas

Physiology

Genes & Molecular Sequences

Amino Acid Sequences

Anatomy

Procedures

Cloning, Molecular

Phenomena

Protein Binding

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Publications

TOP 3
Gregor Schaffar; Peter Breuer; Raina Boteva; Christian Behrends; Nikolay Tzvetkov; Nadine Strippel; Hideki Sakahira; Katja Siegers; Manajit Hayer-Hartl; F Ulrich Hartl
Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation.
Hideki Sakahira; Peter Breuer; Manajit Hayer-Hartl; F Ulrich Hartl
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity.
Hideki Sakahira; Shigekazu Nagata
Co-translational folding of caspase-activated DNase with Hsp70, Hsp40, and inhibitor of caspase-activated DNase.

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All Publications

2004: Gregor Schaffar; Peter Breuer; Raina Boteva; Christian Behrends; Nikolay Tzvetkov; Nadine Strippel; Hideki Sakahira; Katja Siegers; Manajit Hayer-Hartl; F Ulrich Hartl
Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation.
Molecular cell 2004;15(1):95-105.
2002: Hideki Sakahira; Peter Breuer; Manajit Hayer-Hartl; F Ulrich Hartl
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99 Suppl 4():16412-8.
2002: Hideki Sakahira; Shigekazu Nagata
Co-translational folding of caspase-activated DNase with Hsp70, Hsp40, and inhibitor of caspase-activated DNase.
The Journal of biological chemistry 2002;277(5):3364-70.
2001: Hideki Sakahira; Y Takemura; Shigekazu Nagata
Enzymatic active site of caspase-activated DNase (CAD) and its inhibition by inhibitor of CAD.
Archives of biochemistry and biophysics 2001;388(1):91-9.
2001: T Otomo; Toshio Yamazaki; Koichi Uegaki; Hideki Sakahira; Shigekazu Nagata
[Structure and function of the CAD domains of caspase-activated DNase(CAD) and inhibitor of CAD].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2001;46(3):233-9.
2000: T Otomo; Hideki Sakahira; Koichi Uegaki; Shigekazu Nagata; Toshio Yamazaki
Structure of the heterodimeric complex between CAD domains of CAD and ICAD.
Nature structural biology 2000;7(8):658-62.
2000: Naomi Mukae; Hideki Yokoyama; T Yokokura; Yasuhiko Sakoyama; Hideki Sakahira; Shigekazu Nagata
Identification and developmental expression of inhibitor of caspase-activated DNase (ICAD) in Drosophila melanogaster.
The Journal of biological chemistry 2000;275(28):21402-8.
2000: Hideki Yokoyama; Naomi Mukae; Hideki Sakahira; K Okawa; Akihiro Iwamatsu; Shigekazu Nagata
A novel activation mechanism of caspase-activated DNase from Drosophila melanogaster.
The Journal of biological chemistry 2000;275(17):12978-86.
2000: Koichi Uegaki; T Otomo; Hideki Sakahira; M Shimizu; Noboru Yumoto; Yoshimasa Kyogoku; Shigekazu Nagata; Toshio Yamazaki
Structure of the CAD domain of caspase-activated DNase and interaction with the CAD domain of its inhibitor.
Journal of molecular biology 2000;297(5):1121-8.
2000: Hideki Sakahira; Akihiro Iwamatsu; Shigekazu Nagata
Specific chaperone-like activity of inhibitor of caspase-activated DNase for caspase-activated DNase.
The Journal of biological chemistry 2000;275(11):8091-6.
2000: Dorian McIlroy; M Tanaka; Hideki Sakahira; Hidehiro Fukuyama; M Suzuki; K Yamamura; Y Ohsawa; Y Uchiyama; Shigekazu Nagata
An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes.
Genes & development 2000;14(5):549-58.
1999: Dorian McIlroy; Hideki Sakahira; Robert Talanian; Shigekazu Nagata
Involvement of caspase 3-activated DNase in internucleosomal DNA cleavage induced by diverse apoptotic stimuli.
Oncogene 1999;18(31):4401-8.
1999: Kohki Kawane; Hidehiro Fukuyama; M Adachi; Hideki Sakahira; N G Copeland; D J Gilbert; N A Jenkin; Shigekazu Nagata
Structure and promoter analysis of murine CAD and ICAD genes.
Cell death and differentiation 1999;6(8):745-52.
1999: Hideki Sakahira; M Enari; Shigekazu Nagata
Functional differences of two forms of the inhibitor of caspase-activated DNase, ICAD-L, and ICAD-S.
The Journal of biological chemistry 1999;274(22):15740-4.
1999: Hideki Sakahira; M Enari; Y Ohsawa; Y Uchiyama; Shigekazu Nagata
Apoptotic nuclear morphological change without DNA fragmentation.
Current biology : CB 1999;9(10):543-6.
1998: Kumiko Samejima; Shigenobu Toné; Timothy J Kottke; M Enari; Hideki Sakahira; CA Cooke; F Durrieu; LM Martins; Shigekazu Nagata; Scott H Kaufmann; William C Earnshaw
Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution.
The Journal of cell biology 1998;143(1):225-39.
1998: Naomi Mukae; M Enari; Hideki Sakahira; Y Fukuda; Johji Inazawa; Hiroyuki Toh; Shigekazu Nagata
Molecular cloning and characterization of human caspase-activated DNase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9123-8.
1998: Hideki Sakahira; M Enari; Shigekazu Nagata
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis.
Nature 1998;391(6662):96-9.
1998: M Enari; Hideki Sakahira; Hideki Yokoyama; K Okawa; Akihiro Iwamatsu; Shigekazu Nagata
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD.
Nature 1998;391(6662):43-50.