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Toshiyuki Sakai

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Motoki Watanabe; Mayumi Yogosawa; Yoshihiro Sowa; Toshiyuki Sakai
Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells.
Takashi Yoshioka; Jo Kitawaki; Takeshi Yamada; Shingo Yogosawa; Toshiyuki Sakai
Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS.
Masahide Shinnoh; Takeshi Yamada; Takashi Yasuda; Sae Yoshikawa; Mano Horinaka; Tsuneharu Miki; Mie Morita; Toshiyuki Sakai
Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8.

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2013: Motoki Watanabe; Mayumi Yogosawa; Yoshihiro Sowa; Toshiyuki Sakai
Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells.
Cancer science 2013;104(6):687-93.
2013: Takashi Yoshioka; Jo Kitawaki; Takeshi Yamada; Shingo Yogosawa; Toshiyuki Sakai
Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS.
Gynecologic oncology 2013;129(2):425-32.
2013: Masahide Shinnoh; Takeshi Yamada; Takashi Yasuda; Sae Yoshikawa; Mano Horinaka; Tsuneharu Miki; Mie Morita; Toshiyuki Sakai
Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8.
International journal of oncology 2013;42(3):903-11.
2013: Makoto Koyama; Toshiaki Hitomi; Masami Ichikawa; Yosuke Iizumi; Yoshihiro Sowa; Tomoyuki Taniguchi; Motoki Watanabe; Toshiyuki Sakai
Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction.
Oncology reports 2013;29(2):779-84.
2013: Masakatsu Oishi; Wakana Goi; Yosuke Iizumi; Tsuneharu Miki; Tomoyuki Taniguchi; Toshiyuki Sakai
Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2.
PloS one 2013;8(2):e55922.
2012: Shingo Yogosawa; Qi Sun; Kaori Takizawa; Yasumasa Yamada; Shusuke Yasuda; Toshiyuki Sakai
Dehydrozingerone, a structural analogue of curcumin, induces cell-cycle arrest at the G2/M phase and accumulates intracellular ROS in HT-29 human colon cancer cells.
Journal of natural products 2012;75(12):2088-93.
2012: Mitsuhiro Tomosugi; Shusuke Yasuda; Haruna Ikawa; Makoto Koyama; Yoshihiro Sowa; Ryoichi Tanaka; Hein te Riele; Toshiyuki Sakai
Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor.
Cancer science 2012;103(12):2139-43.
2012: Yoshihiro Sowa; Toshiyuki Sakai
[Ras/Raf/MEK/ERK cascade].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():63-6.
2012: Hiroya Taniguchi; Miki Wakada; Kimihiro Yano; Shusuke Yasuda; Tatsushi Yoshida; Ahmed E Goda; Mano Horinaka; Toshiyuki Sakai
Targeting the Glyoxalase pathway enhances TRAIL efficacy in cancer cells by downregulating the expression of antiapoptotic molecules.
Molecular cancer therapeutics 2012;11(10):2294-300.
2012: Jun Fujiwara; Mano Horinaka; Makoto Koyama; Tsuneharu Miki; Yoshihiro Sowa; Miki Wakada; Toshiyuki Sakai
The anti-obesity drug orlistat promotes sensitivity to TRAIL by two different pathways in hormone-refractory prostate cancer cells.
International journal of oncology 2012;40(5):1483-91.
2012: Yasuyuki Izutani; Yoshihiro Sowa; Shingo Yogosawa; Toshiyuki Sakai
Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the phosphatidylinositol 3-kinase signaling pathway in human colon cancer cells.
International journal of oncology 2012;40(3):816-24.
2012: Mano Horinaka; Susumu Nakata; Takumi Shiraishi; Mitsuhiro Tomosugi; Miki Wakada; Tatsushi Yoshida; Sae Yoshikawa; Toshiyuki Sakai
Aclarubicin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis through death receptor 5 upregulation.
Cancer science 2012;103(2):282-7.
2012: Chaitali Tophkhane; Shi-He Yang; Shingo Yogosawa; Shrikant Anant; Susan Edgerton; Yunbo Jiang; Wan-Guo Liu; Zhikun Ma; Toshiyuki Sakai; Dharmalingam Subramaniam; Ann Thor; Xiaohe Yang
p53 inactivation upregulates p73 expression through E2F-1 mediated transcription.
PloS one 2012;7(8):e43564.
2011: Takayuki Yamaguchi; Reina Kakefuda; Nobuyuki Tajima; Yoshihiro Sowa; Toshiyuki Sakai
Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo.
International journal of oncology 2011;39(1):23-31.
2011: Kimihiro Yano; Mano Horinaka; Tatsushi Yoshida; Takashi Yasuda; Hiroya Taniguchi; Ahmed E Goda; Miki Wakada; Sae Yoshikawa; Terukazu Nakamura; Akihiro Kawauchi; Tsuneharu Miki; Toshiyuki Sakai
Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells.
International journal of oncology 2011;38(2):365-74.
2011: Toshiyuki Sakai
["Molecular-targeting prevention" of cancer. The theory and its possibilities].
Nihon eiseigaku zasshi. Japanese journal of hygiene 2011;66(1):3-12.
2010: Taka-Aki Matsui; Hiroaki Murata; Yoshihiro Sowa; Tomoya Sakabe; Kazutaka Koto; Naoyuki Horie; Yoshiro Tsuji; Toshiyuki Sakai; Toshikazu Kubo
A novel MEK1/2 inhibitor induces G1/S cell cycle arrest in human fibrosarcoma cells.
Oncology reports 2010;24(2):329-33.
2010: Tatsushi Yoshida; Mano Horinaka; Toshiyuki Sakai
"Combination-oriented molecular-targeting prevention" of cancer: a model involving the combination of TRAIL and a DR5 inducer.
Environmental health and preventive medicine 2010;15(4):203-10.
2010: Makoto Koyama; Yasuyuki Izutani; Ahmed E Goda; Taka-aki Matsui; Mano Horinaka; Mitsuhiro Tomosugi; Jun Fujiwara; Yoshitaka Nakamura; Miki Wakada; Shingo Yogosawa; Yoshihiro Sowa; Toshiyuki Sakai
Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(8):2320-32.
2010: Shusuke Yasuda; Shingo Yogosawa; Yasuyuki Izutani; Yoshitaka Nakamura; Hirotsuna Watanabe; Toshiyuki Sakai
Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells.
Molecular nutrition & food research 2010;54(4):559-65.
2010: Hiroyuki Kikuchi; Takashi Ohtsuki; Takashi Koyano; Thaworn Kowithayakorn; Toshiyuki Sakai; Masami Ishibashi
Activity of mangosteen xanthones and teleocidin a-2 in death receptor expression enhancement and tumor necrosis factor related apoptosis-inducing ligand assays.
Journal of natural products 2010;73(3):452-5.
2010: Hitoji Uchiyama; Yoshihiro Sowa; Miki Wakada; Mayumi Yogosawa; Ryoko Nakanishi; Mano Horinaka; Chihiro Shimazaki; Masafumi Taniwaki; Toshiyuki Sakai
Cyclin-dependent kinase inhibitor SU9516 enhances sensitivity to methotrexate in human T-cell leukemia Jurkat cells.
Cancer science 2010;101(3):728-34.
2010: Mano Horinaka; Tatsushi Yoshida; Atsuko Kishi; Kaoru Akatani; Takashi Yasuda; Junji Kouhara; Miki Wakada; Toshiyuki Sakai
Lactobacillus strains induce TRAIL production and facilitate natural killer activity against cancer cells.
FEBS letters 2010;584(3):577-82.
2009: Satoshi Nakayama; Yasuhiro Torikoshi; Takeshi Takahashi; Tomokazu Yoshida; Tamotsu Sudo; Tomoko Matsushima; Yuko Kawasaki; Aya Katayama; Keigo Gohda; Gabriel N Hortobagyi; Shinzaburo Noguchi; Toshiyuki Sakai; Hideki Ishihara; Naoto T Ueno
Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells.
Breast cancer research : BCR 2009;11(1):R12.
2009: Hideki Ishikawa; Tomiyo Nakamura; Atsuko Kawano; Nobuhisa Gondo; Toshiyuki Sakai
Chemoprevention of colorectal cancer in Japan: a brief introduction to current clinical trials.
Journal of gastroenterology 2009;44 Suppl 19():77-81.
2008: Hiroya Taniguchi; Tatsushi Yoshida; Mano Horinaka; Takashi Yasuda; Ahmed E Goda; Masako Konishi; Miki Wakada; Keisho Kataoka; Toshikazu Yoshikawa; Toshiyuki Sakai
Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells.
Cancer research 2008;68(21):8918-27.
2008: Tatsushi Yoshida; Masako Konishi; Mano Horinaka; Takashi Yasuda; Ahmed E Goda; Hiroya Taniguchi; Kimihiro Yano; Miki Wakada; Toshiyuki Sakai
Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis.
Biochemical and biophysical research communications 2008;375(1):129-33.
2008: Tatsushi Yoshida; Mano Horinaka; Mami Takara; Mayuko Tsuchihashi; Nobuhiro Mukai; Miki Wakada; Toshiyuki Sakai
Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells.
Environmental health and preventive medicine 2008;13(5):281-7.
2008: A E Goda; Tatsushi Yoshida; Mano Horinaka; T Yasuda; Takumi Shiraishi; Miki Wakada; Toshiyuki Sakai
Mechanisms of enhancement of TRAIL tumoricidal activity against human cancer cells of different origin by dipyridamole.
Oncogene 2008;27(24):3435-45.
2008: Koichi Takagi; Yoshihiro Sowa; Ozgur Muhammer Cevik; Ryoko Nakanishi; Toshiyuki Sakai
CDK inhibitor enhances the sensitivity to 5-fluorouracil in colorectal cancer cells.
International journal of oncology 2008;32(5):1105-10.
2008: Youichirou Matsuzaki; Makoto Koyama; Toshiaki Hitomi; Tomoya Yokota; Mayumi Kawanaka; Akiyoshi Nishikawa; Doris Germain; Toshiyuki Sakai
Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression.
Oncology reports 2008;19(3):721-7.
2007: Taka-Aki Matsui; Hiroaki Murata; Tomoya Sakabe; Yoshihiro Sowa; Naoyuki Horie; Ryoko Nakanishi; Toshiyuki Sakai; Toshikazu Kubo
Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.
Oncology reports 2007;18(5):1263-8.
2007: Tatsushi Yoshida; Takumi Shiraishi; Mano Horinaka; Miki Wakada; Toshiyuki Sakai
Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin.
Oncology reports 2007;18(5):1239-42.
2007: Takayuki Yamaguchi; Takayuki Yoshida; Reina Kurachi; Junya Kakegawa; Yoshikazu Hori; Toyomichi Nanayama; Kazuhide Hayakawa; Hiroyuki Abe; Koichi Takagi; Youichirou Matsuzaki; Makoto Koyama; Shingo Yogosawa; Yoshihiro Sowa; Takao Yamori; Nobuyuki Tajima; Toshiyuki Sakai
Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor.
Cancer science 2007;98(11):1809-16.
2007: Taka-aki Matsui; Yoshihiro Sowa; Hiroaki Murata; Koichi Takagi; Ryoko Nakanishi; Shunji Aoki; Masayuki Yoshikawa; Motomasa Kobayashi; Tomoya Sakabe; Toshikazu Kubo; Toshiyuki Sakai
The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line.
International journal of oncology 2007;31(4):915-22.
2007: Tatsushi Yoshida; Takumi Shiraishi; Mano Horinaka; Susumu Nakata; Takashi Yasuda; Ahmed E Goda; Miki Wakada; Yoichi Mizutani; Tsuneharu Miki; Akiyoshi Nishikawa; Toshiyuki Sakai
Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis.
Cancer science 2007;98(9):1417-23.
2007: Tomoya Yokota; Youichirou Matsuzaki; Makoto Koyama; Toshiaki Hitomi; Mayumi Kawanaka; Masako Enoki-Konishi; Yusuke Okuyama; Junko Takayasu; Hoyoku Nishino; Akiyoshi Nishikawa; Toshihiko Osawa; Toshiyuki Sakai
Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells.
Cancer science 2007;98(9):1447-53.
2007: Tatsushi Yoshida; Takashi Maoka; Swadesh K Das; Kazuki Kanazawa; Mano Horinaka; Miki Wakada; Yoshiko Satomi; Hoyoku Nishino; Toshiyuki Sakai
Halocynthiaxanthin and peridinin sensitize colon cancer cell lines to tumor necrosis factor-related apoptosis-inducing ligand.
Molecular cancer research : MCR 2007;5(6):615-25.
2007: Makoto Koyama; Youichirou Matsuzaki; Shingo Yogosawa; Toshiaki Hitomi; Mayumi Kawanaka; Toshiyuki Sakai
ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway.
Molecular cancer therapeutics 2007;6(5):1579-87.
2007: Toshiaki Hitomi; Youichirou Matsuzaki; Shusuke Yasuda; Mayumi Kawanaka; Shingo Yogosawa; Makoto Koyama; Dean Tantin; Toshiyuki Sakai
Oct-1 is involved in the transcriptional repression of the p15(INK4b) gene.
FEBS letters 2007;581(6):1087-92.
2007: Junji Kouhara; Tatsushi Yoshida; Susumu Nakata; Mano Horinaka; Miki Wakada; Yuji Ueda; Hisakazu Yamagishi; Toshiyuki Sakai
Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines.
International journal of oncology 2007;30(3):679-87.
2006: Taka-aki Matsui; Yoshihiro Sowa; Tatsushi Yoshida; Hiroaki Murata; Mano Horinaka; Miki Wakada; Ryoko Nakanishi; Tomoya Sakabe; Toshikazu Kubo; Toshiyuki Sakai
Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells.
Carcinogenesis 2006;27(9):1768-77.
2006: Susumu Nakata; Tatsushi Yoshida; Takumi Shiraishi; Mano Horinaka; Junji Kouhara; Miki Wakada; Toshiyuki Sakai
15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis.
Molecular cancer therapeutics 2006;5(7):1827-35.
2006: Moriatsu Izumi; Shingo Yogosawa; Shunji Aoki; Hirotsuna Watanabe; Jun Kamiyama; Yoshinori Takahara; Yoshihiro Sowa; Motomasa Kobayashi; Hajime Hosoi; Tohru Sugimoto; Toshiyuki Sakai
A novel synthetic drug, LB-18, closely related to lembehyne-A derived from a marine sponge, induces caspase-independent cell death to human neuroblastoma cells.
International journal of oncology 2006;29(1):169-73.
2006: Mano Horinaka; Tatsushi Yoshida; Takumi Shiraishi; Susumu Nakata; Miki Wakada; Toshiyuki Sakai
The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand.
Molecular cancer therapeutics 2006;5(4):945-51.
2006: Yoshinori Takahara; Shingo Yogosawa; Sakiko Maruyama; Noriko Watanabe; Hirofumi Yokoyama; Kazuteru Fukasawa; Yoshikazu Sukenaga; Jun Kamiyama; Moriatsu Izumi; Miki Wakada; Helin Zhang; Kaname Yoshizawa; Shigeyuki Kawa; Toshio Nikaido; Toshiyuki Sakai
Lysocellin, a metabolite of the novel drug 'alopestatin', induces G1 arrest and prevents cytotoxicity induced by etoposide.
International journal of oncology 2006;28(4):823-9.
2005: Mano Horinaka; Tatsushi Yoshida; Takumi Shiraishi; Susumu Nakata; Miki Wakada; Ryoko Nakanishi; Hoyoku Nishino; Hiroshi Matsui; Toshiyuki Sakai
Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells.
Oncogene 2005;24(48):7180-9.
2005: Tatsushi Yoshida; Ayaka Maeda; Mano Horinaka; Takumi Shiraishi; Susumu Nakata; Miki Wakada; Shingo Yogosawa; Toshiyuki Sakai
Quercetin induces gadd45 expression through a p53-independent pathway.
Oncology reports 2005;14(5):1299-303.
2005: Hideki Ishihara; Tomokazu Yoshida; Yuko Kawasaki; Hironori Kobayashi; Masatoshi Yamasaki; Satoshi Nakayama; Erika Miki; Kei-Ichiro Shohmi; Tomoko Matsushima; Sachiyo Tada; Yasuhiro Torikoshi; Masakatsu Morita; Shigeyuki Tamura; Yoko Hino; Jun Kamiyama; Yoshihiro Sowa; Yasunari Tsuchihashi; Hisakazu Yamagishi; Toshiyuki Sakai
A new cancer diagnostic system based on a CDK profiling technology.
Biochimica et biophysica acta 2005;1741(3):226-33.
2005: Mano Horinaka; Tatsushi Yoshida; Takumi Shiraishi; Susumu Nakata; Miki Wakada; Ryoko Nakanishi; Hoyoku Nishino; Toshiyuki Sakai
The combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells.
Biochemical and biophysical research communications 2005;333(3):833-8.
2005: Youichirou Matsuzaki; Makoto Koyama; Toshiaki Hitomi; Yuuki Takaoka; Mayumi Kawanaka; Toshiyuki Sakai
15-deoxy-Delta12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor.
International journal of oncology 2005;27(2):497-503.
2005: Takumi Shiraishi; Tatsushi Yoshida; Susumu Nakata; Mano Horinaka; Miki Wakada; Yoichi Mizutani; Tsuneharu Miki; Toshiyuki Sakai
Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells.
Cancer research 2005;65(14):6364-70.
2005: Tatsushi Yoshida; Takumi Shiraishi; Susumu Nakata; Mano Horinaka; Miki Wakada; Yoichi Mizutani; Tsuneharu Miki; Toshiyuki Sakai
Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein.
Cancer research 2005;65(13):5662-7.
2005: Taishi Maeda; Yasuo Nagaoka; Yuki Kawai; Nobumasa Takagaki; Chikako Yasuda; Shingo Yogosawa; Yoshihiro Sowa; Toshiyuki Sakai; Shinichi Uesato
Inhibitory effects of cancer cell proliferation by novel histone deacetylase inhibitors involve p21/WAF1 induction and G2/M arrest.
Biological & pharmaceutical bulletin 2005;28(5):849-53.
2005: Takumi Shiraishi; Tatsushi Yoshida; Susumu Nakata; Mano Horinaka; Miki Wakada; Yoichi Mizutani; Tsuneharu Miki; Toshiyuki Sakai
Differential response at the hGABP/E4TF1 site of retinoblastoma gene promoter in human testicular seminoma cells.
Oncology reports 2005;13(5):871-4.
2005: Youichirou Matsuzaki; Toshiyuki Sakai
INK4 Family -A promising target for 'gene-regulating chemoprevention' and 'molecular-targeting prevention' of cancer.
Environmental health and preventive medicine 2005;10(2):72-7.
2005: Nobumasa Takagaki; Yoshihiro Sowa; Teruki Oki; Ryoko Nakanishi; Shingo Yogosawa; Toshiyuki Sakai
Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway.
International journal of oncology 2005;26(1):185-9.
2004: Teruki Oki; Yoshihiro Sowa; Tohru Hirose; Nobumasa Takagaki; Mano Horinaka; Ryoko Nakanishi; Chikako Yasuda; Tatsushi Yoshida; Motohiro Kanazawa; Yoshiko Satomi; Hoyoku Nishino; Tsuneharu Miki; Toshiyuki Sakai
Genistein induces Gadd45 gene and G2/M cell cycle arrest in the DU145 human prostate cancer cell line.
FEBS letters 2004;577(1-2):55-9.
2004: Youichirou Matsuzaki; Makoto Koyama; Toshiaki Hitomi; Mayumi Kawanaka; Toshiyuki Sakai
Indole-3-carbinol activates the cyclin-dependent kinase inhibitor p15(INK4b) gene.
FEBS letters 2004;576(1-2):137-40.
2004: Tomoya Yokota; Youichirou Matsuzaki; Toshiyuki Sakai
Trichostatin A activates p18INK4c gene: differential activation and cooperation with p19INK4d gene.
FEBS letters 2004;574(1-3):171-5.
2004: Susumu Nakata; Tatsushi Yoshida; Mano Horinaka; Takumi Shiraishi; Miki Wakada; Toshiyuki Sakai
Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells.
Oncogene 2004;23(37):6261-71.
2004: Tomoya Yokota; Youichirou Matsuzaki; Kazuhiro Miyazawa; Frederique Zindy; Martine F Roussel; Toshiyuki Sakai
Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter.
Oncogene 2004;23(31):5340-9.
2004: Youichirou Matsuzaki; Yuuki Takaoka; Toshiaki Hitomi; Hoyoku Nishino; Toshiyuki Sakai
Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c).
Oncogene 2004;23(31):5409-14.
2004: Tatsushi Yoshida; Toshiyuki Sakai
Promoter of TRAIL-R2 gene.
Vitamins and hormones 2004;67():35-49.
2003: Toshiaki Hitomi; Youichirou Matsuzaki; Tomoya Yokota; Yuuki Takaoka; Toshiyuki Sakai
p15(INK4b) in HDAC inhibitor-induced growth arrest.
FEBS letters 2003;554(3):347-50.
2003: Shoichi Saito; Senye Takahashi; Nobumasa Takagaki; Tohru Hirose; Toshiyuki Sakai
15-Deoxy-Delta(12,14)-prostaglandin J2 induces apoptosis through activation of the CHOP gene in HeLa cells.
Biochemical and biophysical research communications 2003;311(1):17-23.
2003: Youichirou Matsuzaki; Yoshihiro Sowa; Tohru Hirose; Tomoya Yokota; Toshiyuki Sakai
Histone deacetylase inhibitors -Promising agents for 'gene-regulating chemoprevention' and 'molecular-targeting prevention' of cancer-.
Environmental health and preventive medicine 2003;8(5):157-60.
2003: Tohru Hirose; Yoshihiro Sowa; Senye Takahashi; Shoichi Saito; Chikako Yasuda; Nobuaki Shindo; Kiyoshi Furuichi; Toshiyuki Sakai
p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y.
Oncogene 2003;22(49):7762-73.
2003: Yoshihiro Sowa; Toshiyuki Sakai
[Gene-regulating chemoprevention against cancer--as a model for "molecular-targeting prevention" of cancer].
Nihon eiseigaku zasshi. Japanese journal of hygiene 2003;58(2):267-74.
2002: Youichirou Matsuzaki; Kazuhiro Miyazawa; Tomoya Yokota; Toshiaki Hitomi; Hisakazu Yamagishi; Toshiyuki Sakai
Molecular cloning and characterization of the human p19(INK4d) gene promoter.
FEBS letters 2002;517(1-3):272-6.
2002: Ayaka Maeda; Tatsushi Yoshida; Katsuyuki Kusuzaki; Toshiyuki Sakai
The characterization of the human Siah-1 promoter(1).
FEBS letters 2002;512(1-3):223-6.
2002: Yoshizumi Matsukawa; Hoyoku Nishino; Mitsunori Yoshida; Hiroyuki Sugihara; Kanade Katsura; Tetsurou Takamatsu; Junichi Okuzumi; Katsuhiko Matsumoto; Fumiko Sato-Nishimori; Toshiyuki Sakai
Quercetin enhances tumorigenicity induced by N-ethyl-N'-nitro-N-nitrosoguanidine in the duodenum of mice.
Environmental health and preventive medicine 2002;6(4):235-9.
2001: T Yoshida; A Maeda; N Tani; Toshiyuki Sakai
Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL-R2 gene.
FEBS letters 2001;507(3):381-5.
2001: N Kanemitsu; MV Kato; F Bai; T Miki; T Inoue; Toshiyuki Sakai
Correlation between induction of the mac25 gene and anti-proliferative effects of 1alpha,25(OH)2-D3 on breast cancer and leukemic cells.
International journal of molecular medicine 2001;7(5):515-20.
2001: K Onishi; M V Kato; F Bai; Toshiyuki Sakai
SMRT as a T3SF-binding protein.
International journal of oncology 2001;18(5):985-9.
2001: Senye Takahashi; S Saito; N Ohtani; Toshiyuki Sakai
Involvement of the Oct-1 regulatory element of the gadd45 promoter in the p53-independent response to ultraviolet irradiation.
Cancer research 2001;61(3):1187-95.
2000: N Kanemitsu; MV Kato; T Miki; S Komatsu; Y Okazaki; Y Hayashizaki; Toshiyuki Sakai
Characterization of the promoter of the murine mac25 gene.
Biochemical and biophysical research communications 2000;279(1):251-7.
2000: Yoshihiro Sowa; Toshiyuki Sakai
Butyrate as a model for "gene-regulating chemoprevention and chemotherapy.".
BioFactors (Oxford, England) 2000;12(1-4):283-7.
1999: T Inoue; J Kamiyama; Toshiyuki Sakai
Sp1 and NF-Y synergistically mediate the effect of vitamin D(3) in the p27(Kip1) gene promoter that lacks vitamin D response elements.
The Journal of biological chemistry 1999;274(45):32309-17.
1999: Y Ding; T Inoue; J Kamiyama; Y Tamura; N Ohtani-Fujita; E Igata; Toshiyuki Sakai
Molecular cloning and functional characterization of the upstream promoter region of the human p73 gene.
DNA research : an international journal for rapid publication of reports on genes and genomes 1999;6(5):347-51.
1999: E Igata; T Inoue; N Ohtani-Fujita; Yoshihiro Sowa; Y Tsujimoto; Toshiyuki Sakai
Molecular cloning and functional analysis of the murine bax gene promoter.
Gene 1999;238(2):407-15.
1999: Yoshihiro Sowa; T Orita; S Minamikawa-Hiranabe; T Mizuno; H Nomura; Toshiyuki Sakai
Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor.
Cancer research 1999;59(17):4266-70.
1999: J Kamiyama; T Inoue; N Ohtani-Fujita; S Minami; Hisakazu Yamagishi; Toshiyuki Sakai
The ubiquitous transcription factor NF-Y positively regulates the transcription of human p27Kip1 through a CCAAT box located in the 5-upstream region of the p27Kip1 gene.
FEBS letters 1999;455(3):281-5.
1999: Yoshihiro Sowa; T Orita; S Hiranabe-Minamikawa; K Nakano; T Mizuno; H Nomura; Toshiyuki Sakai
Histone deacetylase inhibitor activates the p21/WAF1/Cip1 gene promoter through the Sp1 sites.
Annals of the New York Academy of Sciences 1999;886():195-9.
1999: T Fujita; N Ohtani-Fujita; Toshiyuki Sakai; JM Rapaport; Thaddeus P Dryja; M V Kato; K Ishizaki; M S Sasaki; Y Hotta; K Maeda; S Kinoshita; Y Ohnishi; K Minoda
Low frequency of oncogenic mutations in the core promoter region of the RB1 gene.
Human mutation 1999;13(5):410-1.
1999: Y Ding; Y Matsukawa; N OhtaniFujita; D Kato; S Dao; T Fujii; Yuji Naito; Toshikazu Yoshikawa; Toshiyuki Sakai; G A Rosenthal
Growth inhibition of A549 human lung adenocarcinoma cells by L-canavanine is associated with p21/WAF1 induction.
Japanese journal of cancer research : Gann 1999;90(1):69-74.
1998: N Ohtani-Fujita; S Minami; S Mimaki; S Dao; Toshiyuki Sakai
p53-Independent activation of the gadd45 promoter by Delta12-prostaglandin J2.
Biochemical and biophysical research communications 1998;251(2):648-52.
1998: F Bai; T Matsui; N Ohtani-Fujita; Y Matsukawa; Y Ding; Toshiyuki Sakai
Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G1 phase arrest in A549 lung adenocarcinoma cells.
FEBS letters 1998;437(1-2):61-4.
1998: Y Tamura; M Sugimoto; K Ohnishi; Toshiyuki Sakai; Eiji Hara
Differential activity of a variant form of the human Id-1 protein generated by alternative splicing.
FEBS letters 1998;436(2):169-73.
1998: T Matsumoto; N Ohtani-Fujita; Yoshihiro Sowa; F Bai; T Nikaido; T Tamaki; Toshiyuki Sakai
Cell cycle-dependent modulation of promoter activities of RB and WAF1/Cip1 genes.
Japanese journal of cancer research : Gann 1998;89(6):626-33.
1998: K Nakano; Hisakazu Yamagishi; T Oka; Toshiyuki Sakai
[A novel approach for cancer chemoprevention referred to as "gene-regulating chemoprevention"].
Nihon Geka Gakkai zasshi 1998;99(6):373-8.
1998: D Kato; K Miyazawa; Margarida Ruas; Maria Starborg; I Wada; T Oka; Toshiyuki Sakai; Gordon Peters; Eiji Hara
Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts.
FEBS letters 1998;427(2):203-8.
1997: Yoshihiro Sowa; T Orita; S Minamikawa; K Nakano; T Mizuno; H Nomura; Toshiyuki Sakai
Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites.
Biochemical and biophysical research communications 1997;241(1):142-50.
1997: N Ohtani-Fujita; Thaddeus P Dryja; JM Rapaport; T Fujita; S Matsumura; K Ozasa; Y Watanabe; K Hayashi; K Maeda; S Kinoshita; T Matsumura; Y Ohnishi; Y Hotta; R Takahashi; M V Kato; K Ishizaki; M S Sasaki; B Horsthemke; K Minoda; Toshiyuki Sakai
Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma.
Cancer genetics and cytogenetics 1997;98(1):43-9.
1997: K Nakano; T Mizuno; Yoshihiro Sowa; T Orita; T Yoshino; Y Okuyama; T Fujita; N Ohtani-Fujita; Y Matsukawa; T Tokino; Hisakazu Yamagishi; T Oka; H Nomura; Toshiyuki Sakai
Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line.
The Journal of biological chemistry 1997;272(35):22199-206.
1997: Yoshihiro Sowa; Y Shiio; T Fujita; T Matsumoto; Y Okuyama; D Kato; J Inoue; J Sawada; Masahide Goto; H Watanabe; H Handa; Toshiyuki Sakai
Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1.
Cancer research 1997;57(15):3145-8.
1997: S Minami; N Ohtani-Fujita; E Igata; T Tamaki; Toshiyuki Sakai
Molecular cloning and characterization of the human p27Kip1 gene promoter.
FEBS letters 1997;411(1):1-6.
1997: Y Matsukawa; H Nishino; Y Okuyama; T Matsui; T Matsumoto; S Matsumura; Y Shimizu; Yoshihiro Sowa; Toshiyuki Sakai
Effects of quercetin and/or restraint stress on formation of aberrant crypt foci induced by azoxymethane in rat colons.
Oncology 1997;54(2):118-21.
1997: Yuji Naito; Toshikazu Yoshikawa; T Fujii; Yoshio Boku; N Yagi; S Dao; Norimasa Yoshida; M Kondo; H Matsui; N Ohtani-Fujita; Toshiyuki Sakai
Monochloramine-induced cell growth inhibition and apoptosis in a rat gastric mucosal cell line.
Journal of clinical gastroenterology 1997;25 Suppl 1():S179-85.
1996: Y Okuyama; Yoshihiro Sowa; T Fujita; T Mizuno; H Nomura; T Nikaido; T Endo; Toshiyuki Sakai
ATF site of human RB gene promoter is a responsive element of myogenic differentiation.
FEBS letters 1996;397(2-3):219-24.
1996: T Fujita; N Ohtani-Fujita; Toshiyuki Sakai
Identification of an RB-responsive region in the 5' untranslated region of the RB gene.
Cancer letters 1996;101(2):149-57.
1996: Toshiyuki Sakai
[Molecular cancer epidemiology--the present status and future possibilities].
Nihon eiseigaku zasshi. Japanese journal of hygiene 1996;50(6):1036-46.
1994: F Sato; Y Matsukawa; K Matsumoto; H Nishino; Toshiyuki Sakai
Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells.
Biochemical and biophysical research communications 1994;204(2):578-84.
1994: E Savoysky; T Mizuno; Yoshihiro Sowa; H Watanabe; J Sawada; H Nomura; Y Ohsugi; H Handa; Toshiyuki Sakai
The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family.
Oncogene 1994;9(7):1839-46.
1994: N Ohtani-Fujita; T Fujita; R Takahashi; Paul D Robbins; Thaddeus P Dryja; Toshiyuki Sakai
A silencer element in the retinoblastoma tumor-suppressor gene.
Oncogene 1994;9(6):1703-11.
1993: N Ohtani-Fujita; T Fujita; A Aoike; N E Osifchin; Paul D Robbins; Toshiyuki Sakai
CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene.
Oncogene 1993;8(4):1063-7.
1993: Y Matsukawa; N Marui; Toshiyuki Sakai; Y Satomi; M Yoshida; K Matsumoto; H Nishino; A Aoike
Genistein arrests cell cycle progression at G2-M.
Cancer research 1993;53(6):1328-31.
1991: N Marui; H Nishino; Toshiyuki Sakai; A Aoike; K Kawai; M Fukushima
Delta 12-prostaglandin J2 mimics heat shock in inducing cell cycle arrest at G1 phase.
Biochemical and biophysical research communications 1991;179(3):1662-9.
1990: Nobuko Hosokawa; Kazunori Hirayoshi; A Nakai; Y Hosokawa; N Marui; M Yoshida; Toshiyuki Sakai; H Nishino; A Aoike; K Kawai
Flavonoids inhibit the expression of heat shock proteins.
Cell structure and function 1990;15(6):393-401.
1990: N Marui; Toshiyuki Sakai; Nobuko Hosokawa; M Yoshida; A Aoike; K Kawai; H Nishino; M Fukushima
N-myc suppression and cell cycle arrest at G1 phase by prostaglandins.
FEBS letters 1990;270(1-2):15-8.
1990: Nobuko Hosokawa; Y Hosokawa; Toshiyuki Sakai; M Yoshida; N Marui; H Nishino; K Kawai; A Aoike
Inhibitory effect of quercetin on the synthesis of a possibly cell-cycle-related 17-kDa protein, in human colon cancer cells.
International journal of cancer. Journal international du cancer 1990;45(6):1119-24.
1990: M Yoshida; Toshiyuki Sakai; Nobuko Hosokawa; N Marui; K Matsumoto; A Fujioka; H Nishino; A Aoike
The effect of quercetin on cell cycle progression and growth of human gastric cancer cells.
FEBS letters 1990;260(1):10-3.
1989: Toshiyuki Sakai; A Aoike; N Marui; K Kawai; H Nishino; M Fukushima
Protection by cycloheximide against cytotoxicity induced by vincristine, colchicine, or delta 12-prostaglandin J2 on human osteosarcoma cells.
Cancer research 1989;49(5):1193-6.