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Isao Sakaida

Research Profile

Anatomy

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Liver Regeneration

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Takaharu Matsunaga; Jun Nishikawa; Takeshi Okamoto; Satoko Harima; Shinichi Hashimoto; Ryo Tanabe; Isao Sakaida
Effect of capsule placement with transnasal endoscopy.
Takuya Iwamoto; Takuro Hisanaga; Taro Takami; Shuji Terai; Shoko Watanabe; Naoki Yamamoto; Isao Sakaida
Bone-marrow-derived cells cultured in serum-free medium reduce liver fibrosis and improve liver function in carbon-tetrachloride-treated cirrhotic mice.
Mari Saito; Kouhei Sakai; Kohsuke Sasaki; Yutaka Suehiro; Kouichi Hamabe; Yuji Hinoda; Shu Kiyotoki; Akihiro Morishige; Munetaka Nakamura; Jun Nishikawa; Atsunori Oga; Toshiyuki Okada; Takeshi Okamoto; Isao Sakaida
Role of DNA methylation in the development of Epstein-Barr virus-associated gastric carcinoma.

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2013: Takaharu Matsunaga; Jun Nishikawa; Takeshi Okamoto; Satoko Harima; Shinichi Hashimoto; Ryo Tanabe; Isao Sakaida
Effect of capsule placement with transnasal endoscopy.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2013;25(2):156-9.
2013: Takuya Iwamoto; Takuro Hisanaga; Taro Takami; Shuji Terai; Shoko Watanabe; Naoki Yamamoto; Isao Sakaida
Bone-marrow-derived cells cultured in serum-free medium reduce liver fibrosis and improve liver function in carbon-tetrachloride-treated cirrhotic mice.
Cell and tissue research 2013;351(3):487-95.
2013: Mari Saito; Kouhei Sakai; Kohsuke Sasaki; Yutaka Suehiro; Kouichi Hamabe; Yuji Hinoda; Shu Kiyotoki; Akihiro Morishige; Munetaka Nakamura; Jun Nishikawa; Atsunori Oga; Toshiyuki Okada; Takeshi Okamoto; Isao Sakaida
Role of DNA methylation in the development of Epstein-Barr virus-associated gastric carcinoma.
Journal of medical virology 2013;85(1):121-7.
2012: Masako Tsuchiya; Takahiro Yamasaki; Isao Sakaida
Evaluation of a novel non-invasive (13) C-glucose breath test for the identification of diabetes mellitus in cirrhotic patients.
Hepatology research : the official journal of the Japan Society of Hepatology 2012;42(12):1196-201.
2012: Junichi Nishimura; Takeshi Okamoto; Ryou Tanabe; Atsushi Goto; Kouichi Hamabe; Shinichi Hashimoto; Takaharu Matsunaga; Munetaka Nakamura; Jun Nishikawa; Isao Sakaida
[A case of enteric muco-submucosal elongated polyp].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2012;109(11):1940-5.
2012: Munetaka Nakamura; Jun Nishikawa; Junichi Nishimura; Takeshi Okamoto; Mari Saito; Yuki Fukagawa; Atsushi Goto; Kouichi Hamabe; Shu Kiyotoki; Masaaki Satake; Yasuyuki Shirai; Isao Sakaida
Risk factors for delayed bleeding from endoscopic submucosal dissection of gastric neoplasms.
Scandinavian journal of gastroenterology 2012;47(8-9):1108-14.
2012: Ryo Tanabe; Toshikazu Gondo; Shingo Higaki; Isao Sakaida
Preoperative evaluation of early colorectal cancer using an ultrasound mini probe.
Hepato-gastroenterology 2012;59(118):1794-9.
2012: Shuji Terai; Isao Sakaida
[Autologous bone marrow cell infusion therapy to repair and regenerate liver].
Seikagaku. The Journal of Japanese Biochemical Society 2012;84(8):707-11.
2012: Taro Takami; Shuji Terai; Isao Sakaida
Advanced therapies using autologous bone marrow cells for chronic liver disease.
Discovery medicine 2012;14(74):7-12.
2012: Yasuhiro Kuramitsu; Seiji Kaino; Shomei Ryozawa; Isao Sakaida; Shigeyuki Suenaga; Kumiko Taba; Yufeng Wang; Kazuyuki Nakamura
Heat-shock protein 27 plays the key role in gemcitabine-resistance of pancreatic cancer cells.
Anticancer research 2012;32(6):2295-9.
2012: Takahiro Yamasaki; Junichi Zaitsu; Yohei Harima; Isao Hidaka; Tsuyoshi Ishikawa; Takuya Iwamoto; Masaki Maeda; Issei Saeki; Taro Takami; Haruko Tanimoto; Shuji Terai; Koichi Uchida; Yohei Urata; Yuhki Yamaguchi; Isao Sakaida
Effect of transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma.
Journal of gastroenterology 2012;47(6):715-22.
2012: Toshiyuki Oishi; Shuji Terai; Koichi Fujisawa; Shinya Kuwashiro; Toshihiko Matsumoto; Hiroshi Nishina; Isao Sakaida
Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model.
Biochemical and biophysical research communications 2012;422(1):22-7.
2012: Shuji Terai; Masako Tsuchiya; Koichi Uchida; Yohei Urata; Naoki Yamamoto; Takahiro Yamasaki; Yuichiro Yokoyama; Junichi Zaitsu; Koji Aoyama; Koichi Fujisawa; Isao Hidaka; Takuro Hisanaga; Tsuyoshi Ishikawa; Takuya Iwamoto; Masaki Maeda; Yoshio Marumoto; Toshihiko Matsumoto; Yuko Mizunaga; Kiwamu Okita; Kaoru Omori; Makoto Segawa; Taro Takami; Haruko Tanimoto; Isao Sakaida
Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy.
Journal of gastroenterology 2012;47(5):491-7.
2012: Tomoya Haraguchi; Kazuhito Itamoto; Hiroshi Nakazawa; Yasutaka Oda; Isao Sakaida; Ryo Takagishi; Kenji Tani; Shuji Terai; Naoki Yamamoto; Yasuho Taura
Therapeutic potential of canine bone marrow stromal cells (BMSCs) in the carbon tetrachloride (CCl4) induced chronic liver dysfunction mouse model.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2012;74(5):607-11.
2012: Tomoya Haraguchi; Kazuhito Itamoto; Masato Koga; Hiroshi Nakazawa; Yasutaka Oda; Isao Sakaida; Kenji Tani; Shuji Terai; Naoki Yamamoto; Yasuho Taura
Matrix metalloproteinases (MMPs) activity in cultured canine bone marrow stromal cells (BMSCs).
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2012;74(5):633-6.
2012: Takahiro Yamasaki; Isao Sakaida
Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma and future treatments for the poor responders.
Hepatology research : the official journal of the Japan Society of Hepatology 2012;42(4):340-8.
2012: Masaki Maeda; Taro Takami; Shuji Terai; Isao Sakaida
Autologous bone marrow cell infusions suppress tumor initiation in hepatocarcinogenic mice with liver cirrhosis.
Journal of gastroenterology and hepatology 2012;27 Suppl 2():104-11.
2012: Takuya Iwamoto; Yuko Mizunaga; Hiroshi Nishina; Kaoru Omori; Shuji Terai; Koichi Uchida; Naoki Yamamoto; Takahiro Yamasaki; Yasuhiko Fujii; Isao Sakaida
Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients.
Journal of gastroenterology 2012;47(3):300-12.
2012: Manabu Sen-Yo; Shigeyuki Suenaga; Toshiyuki Uekitani; Kanako Yoshida; Megumi Harano; Seiji Kaino; Isao Sakaida
Utility of the Anterior Oblique-Viewing Endoscope and the Double-Balloon Enteroscope for Endoscopic Retrograde Cholangiopancreatography in Patients with Billroth II Gastrectomy.
Gastroenterology research and practice 2012;2012():389269.
2012: Yuko Mizunaga; Hiroshi Nishina; Yusuke Fujita; Yoshihiko Hamamoto; Koh Shinoda; Shuji Terai; Koichi Uchida; Naoki Yamamoto; Takahiro Yamasaki; Isao Sakaida
Granulocyte colony-stimulating factor and interleukin-1β are important cytokines in repair of the cirrhotic liver after bone marrow cell infusion: comparison of humans and model mice.
Cell transplantation 2012;21(11):2363-75.
2011: Isao Sakaida
[Autologous bone marrow cell infusion therapy for liver cirrhosis--now and future].
Rinsho byori. The Japanese journal of clinical pathology 2011;59(12):1092-8.
2011: Yufeng Wang; Yuichiro Yokoyama; Norio Iizuka; Yasuhiro Kuramitsu; Masaaki Oka; Isao Sakaida; Motonari Takashima; Takao Tamesa; Kazuyuki Nakamura
Identification of four isoforms of aldolase B down-regulated in hepatocellular carcinoma tissues by means of two-dimensional Western blotting.
In vivo (Athens, Greece) 2011;25(6):881-6.
2011: Munetaka Nakamura; Jun Nishikawa; Takeshi Okamoto; Mari Saito; Kouichi Hamabe; Shu Kiyotoki; Isao Sakaida
Esophageal squamous papilloma with tentacular processes.
Gastrointestinal endoscopy 2011;74(5):1143-4.
2011: Takuro Hisanaga; Takuya Iwamoto; Toshifumi Matsuyama; Tomoaki Murata; Hiroshi Nishina; Taro Takami; Shuji Terai; Naoki Yamamoto; Isao Sakaida
TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion.
Cell and tissue research 2011;346(1):79-88.
2011: Yasuhiro Kuramitsu; Junko K Akada; Norio Iizuka; Masaaki Oka; Kiwamu Okita; Isao Sakaida; Motonari Takashima; Takao Tamesa; Toshifusa Toda; Yufeng Wang; Yuichiro Yokoyama; Kazuyuki Nakamura
Up-regulation of 42 kDa tubulin alpha-6 chain fragment in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus.
Anticancer research 2011;31(10):3331-6.
2011: Kanako Yoshida; Xiulian Zhang; Shomei Ryozawa; Isao Sakaida; Kumiko Taba; Seiji Kaino; Yasuhiro Kuramitsu; Kohei Murakami; Kazuyuki Nakamura
Proteomic differential display analysis for TS-1-resistant and -sensitive pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry.
Anticancer research 2011;31(6):2103-8.
2011: Toshiyuki Oishi; Shuji Terai; Takuya Iwamoto; Taro Takami; Naoki Yamamoto; Isao Sakaida
Splenectomy reduces fibrosis and preneoplastic lesions with increased triglycerides and essential fatty acids in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet.
Hepatology research : the official journal of the Japan Society of Hepatology 2011;41(5):463-74.
2011: Shinya Kuwashiro; Shuji Terai; Toshiyuki Oishi; Koichi Fujisawa; Toshihiko Matsumoto; Hiroshi Nishina; Isao Sakaida
Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation.
Cell and tissue research 2011;344(1):125-34.
2011: Megumi Harano; Shomei Ryozawa; Hirotoshi Iwano; Kumiko Taba; Manabu Sen-Yo; Isao Sakaida
Clinical impact of endoscopic papillectomy for benign-malignant borderline lesions of the major duodenal papilla.
Journal of hepato-biliary-pancreatic sciences 2011;18(2):190-4.
2011: Takahiro Yamasaki; Satoe Hamabe; Issei Saeki; Yohei Harima; Yuhki Yamaguchi; Koichi Uchida; Shuji Terai; Isao Sakaida
A novel transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma: a prospective randomized trial.
Journal of gastroenterology 2011;46(3):359-66.
2011: Norio Iizuka; Masaaki Oka; Isao Sakaida; Toyoki Moribe; Toshiaki Miura; Naoki Kimura; Shigeru Tamatsukuri; Hideo Ishitsuka; Koichi Uchida; Shuji Terai; Satoyoshi Yamashita; Kiwamu Okita; Koichiro Sakata; Yoshiyasu Karino; Joji Toyota; Eiji Ando; Tatsuya Ide; Michio Sata; Ryouichi Tsunedomi; Masahito Tsutsui; Michihisa Iida; Yoshihiro Tokuhisa; Kazuhiko Sakamoto; Takao Tamesa; Yusuke Fujita; Yoshihiko Hamamoto
Efficient detection of hepatocellular carcinoma by a hybrid blood test of epigenetic and classical protein markers.
Clinica chimica acta; international journal of clinical chemistry 2011;412(1-2):152-8.
2011: Taro Takami; Shuji Terai; Isao Sakaida
Novel findings for the development of drug therapy for various liver diseases: Current state and future prospects for our liver regeneration therapy using autologous bone marrow cells for decompensated liver cirrhosis patients.
Journal of pharmacological sciences 2011;115(3):274-8.
2011: Hirotoshi Iwano; Shomei Ryozawa; Noriko Ishigaki; Kumiko Taba; Manabu Senyo; Kanako Yoshida; Isao Sakaida
Unilateral versus bilateral drainage using self-expandable metallic stent for unresectable hilar biliary obstruction.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2011;23(1):43-8.
2011: Kumiko Taba; Yasuhiro Kuramitsu; Shomei Ryozawa; Kanako Yoshida; T Tanaka; Sayaka Mori-Iwamoto; Shin-ichiro Maehara; Yoshihiko Maehara; Isao Sakaida; Kazuyuki Nakamura
KNK437 downregulates heat shock protein 27 of pancreatic cancer cells and enhances the cytotoxic effect of gemcitabine.
Chemotherapy 2011;57(1):12-6.
2011: Shuji Terai; Isao Sakaida
Autologous bone marrow cell infusion therapy for liver cirrhosis patients.
Journal of hepato-biliary-pancreatic sciences 2011;18(1):23-5.
2010: Kazuo Hashimoto; Shingo Higaki; Makoto Nishiahi; Keiko Fujiwara; Toshikazu Gondo; Isao Sakaida
Does chromoendoscopy improve the colonoscopic adenoma detection rate?
Hepato-gastroenterology 2010;57(104):1399-404.
2010: Shu Kiyotoki; Jun Nishikawa; Masaaki Satake; Yuki Fukagawa; Yasuyuki Shirai; Kouichi Hamabe; Mari Saito; Takeshi Okamoto; Isao Sakaida
Usefulness of magnifying endoscopy with narrow-band imaging for determining gastric tumor margin.
Journal of gastroenterology and hepatology 2010;25(10):1636-41.
2010: Yasuhiro Kuramitsu; Kumiko Taba; Shomei Ryozawa; Kanako Yoshida; Xiulian Zhang; T Tanaka; Shin-Ichiro Maehara; Yoshihiro Maehara; Isao Sakaida; Kazuyuki Nakamura
Identification of up- and down-regulated proteins in gemcitabine-resistant pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry.
Anticancer research 2010;30(9):3367-72.
2010: Jun Nishikawa; Masaaki Satake; Kouichi Hamabe; Yuki Fukagawa; Yasuyuki Shirai; Shu Kiyotoki; Mari Saito; Takeshi Okamoto; Isao Sakaida
Fine-tuning the criteria for strip biopsy and endoscopic submucosal dissection improves the outcome of early gastric carcinoma treatment.
Journal of gastroenterology and hepatology 2010;25(9):1514-7.
2010: Kumiko Taba; Yasuhiro Kuramitsu; Shomei Ryozawa; Kanako Yoshida; Toshiyuki Tanaka; Shin-Ichiro Maehara; Yoshihiro Maehara; Isao Sakaida; Kazuyuki Nakamura
Heat-shock protein 27 is phosphorylated in gemcitabine-resistant pancreatic cancer cells.
Anticancer research 2010;30(7):2539-43.
2010: Shomei Ryozawa; Hirotoshi Iwano; Kumiko Taba; Manabu Senyo; Isao Sakaida
Successful retrieval of an impacted mechanical lithotripsy basket: a case report.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2010;22 Suppl 1():S111-3.
2010: Toshihiko Matsumoto; Shuji Terai; Toshiyuki Oishi; Shinya Kuwashiro; Koichi Fujisawa; Naoki Yamamoto; Yusuke Fujita; Yoshihiko Hamamoto; Makoto Furutani-Seiki; Hiroshi Nishina; Isao Sakaida
Medaka as a model for human nonalcoholic steatohepatitis.
Disease models & mechanisms 2010;3(7-8):431-40.
2010: Yohei Harima; Takahiro Yamasaki; Satoe Hamabe; Issei Saeki; Kohsuke Okita; Shuji Terai; Isao Sakaida
Effect of a late evening snack using branched-chain amino acid-enriched nutrients in patients undergoing hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma.
Hepatology research : the official journal of the Japan Society of Hepatology 2010;40(6):574-84.
2010: Toshiyuki Okada; Yutaka Suehiro; Koji Ueno; Shoko Mitomori; Sayaka Kaneko; Mitsuaki Nishioka; Naoko Okayama; Kouhei Sakai; Shingo Higaki; Shoichi Hazama; Hiroshi Hirata; Isao Sakaida; Masaaki Oka; Yuji Hinoda
TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer.
Genes, chromosomes & cancer 2010;49(5):452-62.
2010: Masahito Tsutsui; Norio Iizuka; Toyoki Moribe; Toshiaki Miura; Naoki Kimura; Shigeru Tamatsukuri; Hideo Ishitsuka; Yusuke Fujita; Yoshihiko Hamamoto; Ryouichi Tsunedomi; Michihisa Iida; Yoshihiro Tokuhisa; Kazuhiko Sakamoto; Takao Tamesa; Isao Sakaida; Masaaki Oka
Methylated cyclin D2 gene circulating in the blood as a prognosis predictor of hepatocellular carcinoma.
Clinica chimica acta; international journal of clinical chemistry 2010;411(7-8):516-20.
2010: Hideko Onoda; Kensaku Shimizu; Yasuo Washida; Naofumi Matsunaga; Shingo Higaki; Shinichi Hashimoto; Takaharu Matsunaga; Isao Sakaida
Usefulness of computed tomography enteroclysis in the intestinal tract.
Japanese journal of radiology 2010;28(3):193-8.
2010: Sayaka Iwamoto; Shomei Ryozawa; Hironori Yamamoto; Kumiko Taba; Noriko Ishigaki; Megumi Harano; Hirotoshi Iwano; Isao Sakaida
Double balloon endoscope facilitates endoscopic retrograde cholangiopancreatography in roux-en-y anastomosis patients.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2010;22(1):64-8.
2009: Shu Kiyotoki; Jun Nishikawa; Haruko Tanimoto; Mari Saito; Kouichi Hamabe; Takeshi Okamoto; Tetsuo Noguchi; Isao Sakaida
[A case of effective photodynamic therapy for local recurrence after definitive chemoradiotherapy for esophageal cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 2009;36(12):2055-7.
2009: Makoto Segawa; Isao Sakaida
Diagnosis and treatment of portal hypertension.
Hepatology research : the official journal of the Japan Society of Hepatology 2009;39(10):1039-43.
2009: Sayaka Mori-Iwamoto; Kumiko Taba; Yasuhiro Kuramitsu; Shomei Ryozawa; Toshiyuki Tanaka; Shin-ichiro Maehara; Yoshihiro Maehara; Kiwamu Okita; Kazuyuki Nakamura; Isao Sakaida
Interferon-gamma down-regulates heat shock protein 27 of pancreatic cancer cells and helps in the cytotoxic effect of gemcitabine.
Pancreas 2009;38(2):224-6.
2009: Satoe Takaki-Hamabe; Takahiro Yamasaki; Issei Saeki; Yohei Harima; Kohsuke Okita; Shuji Terai; Isao Sakaida
Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma: Is the addition of subcutaneous interferon-alpha-2b beneficial?
Hepatology research : the official journal of the Japan Society of Hepatology 2009;39(3):223-30.
2009: Noriko Ishigaki; Naoki Yamamoto; Haiyan Jin; Kouichi Uchida; Shuji Terai; Isao Sakaida
Continuos intravenous infusion of atrial natriuretic peptide (ANP) prevented liver fibrosis in rat.
Biochemical and biophysical research communications 2009;378(3):354-9.
2009: Shomei Ryozawa; Sayaka Iwamoto; Hirotoshi Iwano; Noriko Ishigaki; Kumiko Taba; Isao Sakaida
ERCP using double-balloon endoscopes in patients with Roux-en-Y anastomosis.
Journal of hepato-biliary-pancreatic surgery 2009;16(5):613-7.
2009: Keiko Korenaga; Masataka Korenaga; Matakazu Furukawa; Takahiro Yamasaki; Isao Sakaida
Usefulness of Sonazoid contrast-enhanced ultrasonography for hepatocellular carcinoma: comparison with pathological diagnosis and superparamagnetic iron oxide magnetic resonance images.
Journal of gastroenterology 2009;44(7):733-41.
2008: Shuji Terai; Isao Sakaida
Current status of autologous bone marrow cell infusion therapy for liver cirrhosis patients.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38 Suppl 1():S72-5.
2008: Michihisa Iida; Norio Iizuka; Isao Sakaida; Toyoki Moribe; Nozomi Fujita; Toshiaki Miura; Shigeru Tamatsukuri; Hideo Ishitsuka; Koichi Uchida; Shuji Terai; Yoshihiro Tokuhisa; Kazuhiko Sakamoto; Takao Tamesa; Takanobu Miyamoto; Yoshihiko Hamamoto; Masaaki Oka
Relation between serum levels of cell-free DNA and inflammation status in hepatitis C virus-related hepatocellular carcinoma.
Oncology reports 2008;20(4):761-5.
2008: Isao Sakaida
Autologous bone marrow cell infusion therapy for liver cirrhosis.
Journal of gastroenterology and hepatology 2008;23(9):1349-53.
2008: Mie Ando; Masataka Korenaga; Keisuke Hino; Masanori Ikeda; Nobuyuki Kato; Sohji Nishina; Isao Hidaka; Isao Sakaida
Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication.
Liver international : official journal of the International Association for the Study of the Liver 2008;28(8):1158-66.
2008: Ryu Shiraishi; Takahiro Yamasaki; Issei Saeki; Kohsuke Okita; Yuhki Yamaguchi; Koichi Uchida; Shuji Terai; Isao Sakaida
Pilot study of combination therapy with transcatheter arterial infusion chemotherapy using iodized oil and percutaneous radiofrequency ablation during occlusion of hepatic blood flow for hepatocellular carcinoma.
American journal of clinical oncology 2008;31(4):311-6.
2008: Yuki Fukagawa; Jun Nishikawa; Yasuhiro Kuramitsu; Dai Iwakiri; Kenzo Takada; Shousuke Imai; Masaaki Satake; Takeshi Okamoto; Masanori Fujimoto; Kiwamu Okita; Kazuyuki Nakamura; Isao Sakaida
Epstein-Barr virus upregulates phosphorylated heat shock protein 27 kDa in carcinoma cells using the phosphoinositide 3-kinase/Akt pathway.
Electrophoresis 2008;29(15):3192-200.
2008: Yasuyuki Shirai; Tomoharu Yoshida; Ryu Shiraishi; Takeshi Okamoto; Hiroki Nakamura; Toshiya Harada; Jun Nishikawa; Isao Sakaida
Prospective randomized study on the use of a computer-based endoscopic simulator for training in esophagogastroduodenoscopy.
Journal of gastroenterology and hepatology 2008;23(7 Pt 1):1046-50.
2008: Shinji Iwasaki; Hiromasa Ohira; Shuhei Nishiguchi; Mikio Zeniya; Shuichi Kaneko; Morikazu Onji; Hiromi Ishibashi; Isao Sakaida; Shigeki Kuriyama; Takafumi Ichida; Saburo Onishi; Gotaro Toda
The efficacy of ursodeoxycholic acid and bezafibrate combination therapy for primary biliary cirrhosis: A prospective, multicenter study.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(6):557-64.
2008: Sayaka Mori-Iwamoto; Yasuhiro Kuramitsu; Shomei Ryozawa; Kumiko Taba; Masanori Fujimoto; Kiwamu Okita; Kazuyuki Nakamura; Isao Sakaida
A proteomic profiling of gemcitabine resistance in pancreatic cancer cell lines.
Molecular medicine reports 2008;1(3):429-34.
2008: Toshiyuki Ooishi; Jun Nishikawa; Masaaki Satake; Yuki Fukagawa; Takeshi Okamoto; Isao Sakaida
Ulceration after arterial microcoil embolization.
Gastrointestinal endoscopy 2008;67(4):723; discussion 724.
2008: Yoshio Marumoto; Shuji Terai; Yohei Urata; Toshihiko Matsumoto; Yuko Mizunaga; Naoki Yamamoto; Haiyan Jin; Koichi Fujisawa; Tomoaki Murata; Koh Shinoda; Hiroshi Nishina; Isao Sakaida
Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver.
Biochemical and biophysical research communications 2008;367(3):546-52.
2008: Yuichiro Yokoyama; Yasuhiro Kuramitsu; Motonari Takashima; Masanori Fujimoto; Norio Iizuka; Shuji Terai; Kiwamu Okita; Isao Sakaida; Masaaki Oka; Deborah A Raynes; Vince Guerriero; Kazuyuki Nakamura
Increased expression of heat shock protein-binding protein 1 and heat shock protein 70 in human hepatocellular carcinoma tissues.
Molecular medicine reports 2008;1(2):197-201.
2008: Keiko Korenaga; Masaaki Korenaga; Koichi Uchida; Takahiro Yamasaki; Isao Sakaida
Effects of a late evening snack combined with alpha-glucosidase inhibitor on liver cirrhosis.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(11):1087-97.
2008: Sohji Nishina; Keisuke Hino; Masataka Korenaga; Chiara Vecchi; Antonello Pietrangelo; Yoichi Mizukami; Takakazu Furutani; Aya Sakai; Michiari Okuda; Isao Hidaka; Kiwamu Okita; Isao Sakaida
Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription.
Gastroenterology 2008;134(1):226-38.
2008: Yumiko Isobe-Harima; Shuji Terai; Izumi Miura; Makoto Segawa; Tomoaki Murata; Kazuhito Itamoto; Yasuho Taura; Koh Shinoda; Isao Sakaida
A new hepatic encephalopathy model to monitor the change of neural amino acids and astrocytes with behaviour disorder.
Liver international : official journal of the International Association for the Study of the Liver 2008;28(1):117-25.
2008: Kazuo Hashimoto; Yoshihisa Shimizu; Yutaka Suehiro; Naoko Okayama; Shinichi Hashimoto; Toshiyuki Okada; Mikako Hiura; Koji Ueno; Shoichi Hazama; Shingo Higaki; Yuichiro Hamanaka; Masaaki Oka; Isao Sakaida; Yuji Hinoda
Hypermethylation status of APC inversely correlates with the presence of submucosal invasion in laterally spreading colorectal tumors.
Molecular carcinogenesis 2008;47(1):1-8.
2007: Haiyan Jin; Naoki Yamamoto; Koichi Uchida; Shuji Terai; Isao Sakaida
Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet.
Biochemical and biophysical research communications 2007;364(4):801-7.
2007: Katsunori Harada; Shingo Higaki; Kazuo Hashimoto; Shinichi Hashimoto; Atsunori Oga; Toshikazu Gondo; Isao Sakaida
Study on the colonoscopic features of GVHD enteritis that developed after hematopoietic stem cell transplantation.
Hepato-gastroenterology 2007;54(80):2221-7.
2007: Sayaka Mori-Iwamoto; Yasuhiro Kuramitsu; Shomei Ryozawa; Kuniko Mikuria; Masanori Fujimoto; Shin-Ichiro Maehara; Yoshihiro Maehara; Kiwamu Okita; Kazuyuki Nakamura; Isao Sakaida
Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine.
International journal of oncology 2007;31(6):1345-50.
2007: Masaaki Satake; Jun Nishikawa; Yuki Fukagawa; Keiko Akashi; Takeshi Okamoto; Tomoharu Yoshida; Atsuyoshi Hirano; Noboru Maetani; Youzou Iida; Isao Sakaida
The long-term efficacy of Helicobacter pylori eradication therapy in patients with idiopathic thrombocytopenic purpura.
Journal of gastroenterology and hepatology 2007;22(12):2233-7.
2007: Y Tokuhisa; Norio Iizuka; Isao Sakaida; T Moribe; N Fujita; Toshiaki Miura; Shigeru Tamatsukuri; Hideo Ishitsuka; Koichi Uchida; Shuji Terai; Kazuhiko Sakamoto; Takao Tamesa; Masaaki Oka
Circulating cell-free DNA as a predictive marker for distant metastasis of hepatitis C virus-related hepatocellular carcinoma.
British journal of cancer 2007;97(10):1399-403.
2007: Kiwamu Okita; Fumie Kurokawa; Takahiro Yamasaki; Isao Sakaida
Screening of hepatocellular cancer: Japanese strategy.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37 Suppl 2():S142-5.
2007: Isao Hidaka; Keisuke Hino; Masataka Korenaga; Toshikazu Gondo; Sohji Nishina; Miye Ando; Michiari Okuda; Isao Sakaida
Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein.
Liver international : official journal of the International Association for the Study of the Liver 2007;27(6):845-53.
2007: Kunihiko Tajima; Shuji Terai; Taro Takami; Kotaro Kawaguchi; Kiwamu Okita; Isao Sakaida
Importance of inhibitor of DNA binding/differentiation 2 in hepatic stellate cell differentiation and proliferation.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37(8):647-55.
2007: Koji Aoyama; Masako Tsuchiya; Kenji Mori; Yoshitsugu Kubo; Kei Shiraishi; Eiki Sakaguchi; Satoyoshi Yamashita; Isao Sakaida
Effect of a late evening snack on outpatients with liver cirrhosis.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37(8):608-14.
2007: Yohei Urata; Kosuke Okita; Keiko Korenaga; Koichi Uchida; Takahiro Yamasaki; Isao Sakaida
The effect of supplementation with branched-chain amino acids in patients with liver cirrhosis.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37(7):510-6.
2007: Haiyan Jin; Shuji Terai; Isao Sakaida
The iron chelator deferoxamine causes activated hepatic stellate cells to become quiescent and to undergo apoptosis.
Journal of gastroenterology 2007;42(6):475-84.
2007: Katsunori Harada; Shingo Higaki; Ayaka Amano; Kazuo Hashimoto; Shinichi Hashimoto; Toshikazu Gondo; Isao Sakaida
A reduced COX-2 expression and a reduced number of pericryptal myofibroblasts are associated with depressed adenoma of the colon.
Oncology reports 2007;17(6):1353-8.
2007: Yumiko Isobe; Takahiro Yamasaki; Yuichirou Yokoyama; Fumie Kurokawa; Keisuke Hino; Isao Sakaida
Hepatocellular carcinoma developing six and a half years after a diagnosis of idiopathic portal hypertension.
Journal of gastroenterology 2007;42(5):407-9.
2007: Kuniko Mikuriya; Yasuhiro Kuramitsu; Shomei Ryozawa; Masanori Fujimoto; Sayaka Mori; Masaaki Oka; Kimikazu Hamano; Kiwamu Okita; Isao Sakaida; Kazuyuki Nakamura
Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry.
International journal of oncology 2007;30(4):849-55.
2007: Tsuyoshi Ishikawa; Shuji Terai; Yohei Urata; Yoshio Marumoto; Koji Aoyama; Tomoaki Murata; Yuko Mizunaga; Naoki Yamamoto; Hiroshi Nishina; Koh Shinoda; Isao Sakaida
Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice.
Cell and tissue research 2007;327(3):463-70.
2007: Shinichi Hashimoto; Shingo Higaki; Ayaka Amano; Katsunori Harada; Jun Nishikawa; Tomoharu Yoshida; Kiwamu Okita; Isao Sakaida
Relationship between molecular markers and endoscopic findings in laterally spreading tumors.
Journal of gastroenterology and hepatology 2007;22(1):30-6.
2006: Norio Iizuka; Isao Sakaida; Toyoki Moribe; Nozomi Fujita; Toshiaki Miura; Markus Stark; Shigeru Tamatsukuri; Hideo Ishitsuka; Koichi Uchida; Shuji Terai; Kazuhiko Sakamoto; Takao Tamesa; Masaaki Oka
Elevated levels of circulating cell-free DNA in the blood of patients with hepatitis C virus-associated hepatocellular carcinoma.
Anticancer research 2006;26(6C):4713-9.
2006: Shuji Terai; Tsuyoshi Ishikawa; Kaoru Omori; Koji Aoyama; Yoshio Marumoto; Yohei Urata; Yuichirou Yokoyama; Koichi Uchida; Takahiro Yamasaki; Yasuhiko Fujii; Kiwamu Okita; Isao Sakaida
Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy.
Stem cells (Dayton, Ohio) 2006;24(10):2292-8.
2006: Shingo Higaki; Kaori Nakano; Sachiko Onaka; Ayaka Amano; Yukari Tanioka; Katsunori Harada; Shinichi Hashimoto; Isao Sakaida; Kiwamu Okita
Clinical significance of measuring blood coagulation factor XIIIA regularly and continuously in patients with Crohn's disease.
Journal of gastroenterology and hepatology 2006;21(9):1407-11.
2006: Motonari Takashima; Yasuhiro Kuramitsu; Yuichiro Yokoyama; Norio Iizuka; Toshio Harada; Masanori Fujimoto; Isao Sakaida; Kiwamu Okita; Masaaki Oka; Kazuyuki Nakamura
Proteomic analysis of autoantibodies in patients with hepatocellular carcinoma.
Proteomics 2006;6(13):3894-900.
2006: Isao Sakaida
[Bone marrow cell as a source of hepatic stem cell].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2006;103(6):607-14.
2006: Masataka Korenaga; Koutaro Kawaguchi; Keiko Korenaga; Kouichi Uchida; Isao Sakaida
[Insulin sensitizer--anti-diabetic drugs, metformin and pioglitazone that can improve insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(6):1157-64.
2006: Takakazu Furutani; Keisuke Hino; Michiari Okuda; Toshikazu Gondo; Sohji Nishina; Akira Kitase; Masataka Korenaga; Shu-Yuan Xiao; Steven Weinman; Stanley M Lemon; Isao Sakaida; Kiwamu Okita
Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein.
Gastroenterology 2006;130(7):2087-98.
2006: Yasuhiro Kuramitsu; Toshio Harada; Motonari Takashima; Yuuichirou Yokoyama; Isao Hidaka; Norio Iizuka; Tosifusa Toda; Masanori Fujimoto; Xiulian Zhang; Isao Sakaida; Kiwamu Okita; Masaaki Oka; Kazuyuki Nakamura
Increased expression and phosphorylation of liver glutamine synthetase in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus.
Electrophoresis 2006;27(8):1651-8.
2006: Yuichiro Yokoyama; Shuji Terai; Tsuyoshi Ishikawa; Koji Aoyama; Yohei Urata; Yoshio Marumoto; Hiroshi Nishina; Kazuyuki Nakamura; Kiwamu Okita; Isao Sakaida
Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation.
Proteomics 2006;6(8):2564-70.
2006: Yuichiro Yokoyama; Yasuhiro Kuramitsu; Motonari Takashima; Norio Iizuka; Shuji Terai; Masaaki Oka; Kazuyuki Nakamura; Kiwamu Okita; Isao Sakaida
Protein level of apolipoprotein E increased in human hepatocellular carcinoma.
International journal of oncology 2006;28(3):625-31.
2006: Tsuyoshi Ishikawa; Shuji Terai; Yohei Urata; Yoshio Marumoto; Koji Aoyama; Isao Sakaida; Tomoaki Murata; Hiroshi Nishina; Koh Shinoda; Shunji Uchimura; Yoshihiko Hamamoto; Kiwamu Okita
Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes.
Cell and tissue research 2006;323(2):221-31.
2005: Isao Sakaida; Shuji Terai; Hiroshi Nishina; Kiwamu Okita
Development of cell therapy using autologous bone marrow cells for liver cirrhosis.
Medical molecular morphology 2005;38(4):197-202.
2005: Isao Sakaida; Kiwamu Okita
The role of oxidative stress in NASH and fatty liver model.
Hepatology research : the official journal of the Japan Society of Hepatology 2005;33(2):128-31.
2005: Jinhua Shen; Isao Sakaida; Koichi Uchida; Shuji Terai; Kiwamu Okita
Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells.
Life sciences 2005;77(13):1502-15.
2005: Isao Sakaida; Kotaro Kawaguchi; Teruaki Kimura; Fusako Tamura; Kiwamu Okita
D-Penicillamine improved laparoscopic and histological findings of the liver in a patient with Wilson's disease: 3-year follow-up after diagnosis of Coombs-negative hemolytic anemia of Wilson's disease.
Journal of gastroenterology 2005;40(6):646-51.
2005: Tsuyoshi Ishikawa; Takahiro Yamasaki; Yumiko Isobe; Isao Sakaida; Fumie Kurokawa; Kiwamu Okita; Teruaki Kimura
Rupture of peritoneal metastatic tumor that developed due to needle-tract implantation of hepatocellular carcinoma.
Journal of gastroenterology 2005;40(5):547-8.
2005: Taro Takami; Shuji Terai; Yuichiro Yokoyama; Haruko Tanimoto; Kunihiko Tajima; Koichi Uchida; Takahiro Yamasaki; Isao Sakaida; Hiroshi Nishina; Snorri S Thorgeirsson; Kiwamu Okita
Human homologue of maid is a useful marker protein in hepatocarcinogenesis.
Gastroenterology 2005;128(5):1369-80.
2005: Haiyan Jin; Isao Sakaida; Masako Tsuchiya; Kiwamu Okita
Herbal medicine Rhei rhizome prevents liver fibrosis in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet.
Life sciences 2005;76(24):2805-16.
2005: Isao Sakaida; Shuji Terai; Kiwamu Okita
Use of bone marrow cells for the development of cellular therapy in liver diseases.
Hepatology research : the official journal of the Japan Society of Hepatology 2005;31(4):195-6.
2005: Isao Sakaida; Teruaki Kimura; Takahiro Yamasaki; Yohei Fukumoto; Keisuke Watanabe; Muneo Aoyama; Kiwamu Okita
Cytochrome c is a possible new marker for fulminant hepatitis in humans.
Journal of gastroenterology 2005;40(2):179-85.
2005: Takahiro Yamasaki; Teruaki Kimura; Fumie Kurokawa; Koji Aoyama; Tsuyoshi Ishikawa; Kunihiko Tajima; Yuichiro Yokoyama; Taro Takami; Kaoru Omori; Kotaro Kawaguchi; Masako Tsuchiya; Shuji Terai; Isao Sakaida; Kiwamu Okita
Percutaneous radiofrequency ablation with cooled electrodes combined with hepatic arterial balloon occlusion in hepatocellular carcinoma.
Journal of gastroenterology 2005;40(2):171-8.
2005: Masako Tsuchiya; Isao Sakaida; Mariko Okamoto; Kiwamu Okita
The effect of a late evening snack in patients with liver cirrhosis.
Hepatology research : the official journal of the Japan Society of Hepatology 2005;31(2):95-103.
2005: Shuji Terai; Isao Sakaida; Hiroshi Nishina; Kiwamu Okita
Lesson from the GFP/CCl4 model--translational research project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis.
Journal of hepato-biliary-pancreatic surgery 2005;12(3):203-7.
2005: Takahiro Yamasaki; Teruaki Kimura; Fumie Kurokawa; Koji Aoyama; Tsuyoshi Ishikawa; Kunihiko Tajima; Yuichiro Yokoyama; Taro Takami; Kaoru Omori; Kotaro Kawaguchi; Masako Tsuchiya; Shuji Terai; Isao Sakaida; Kiwamu Okita
Prognostic factors in patients with advanced hepatocellular carcinoma receiving hepatic arterial infusion chemotherapy.
Journal of gastroenterology 2005;40(1):70-8.
2004: Kaoru Omori; Shuji Terai; Tsuyoshi Ishikawa; Koji Aoyama; Isao Sakaida; Hiroshi Nishina; Koh Shinoda; Shunji Uchimura; Yoshihiko Hamamoto; Kiwamu Okita
Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self-organizing-map-based gene expression.
FEBS letters 2004;578(1-2):10-20.
2004: Isao Sakaida; Shuji Terai; Naoki Yamamoto; Koji Aoyama; Tsuyoshi Ishikawa; Hiroshi Nishina; Kiwamu Okita
Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice.
Hepatology (Baltimore, Md.) 2004;40(6):1304-11.
2004: Eiki Sakaguchi; Isao Sakaida; Kiwamu Okita
[Th1/Th2 balance in HCV-related liver cirrhosis and the effect of TGF-beta on Th1 response: possible implications for the development of hepatoma].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 7(Pt 1):175-8.
2004: Yuichiro Yokoyama; Yasuhiro Kuramitsu; Motonari Takashima; Norio Iizuka; Toshifusa Toda; Shuji Terai; Isao Sakaida; Masaaki Oka; Kazuyuki Nakamura; Kiwamu Okita
Proteomic profiling of proteins decreased in hepatocellular carcinoma from patients infected with hepatitis C virus.
Proteomics 2004;4(7):2111-6.
2004: Isao Sakaida; Koji Hironaka; Teruaki Kimura; Shuji Terai; Takahiro Yamasaki; Kiwamu Okita
Herbal medicine Sho-saiko-to (TJ-9) increases expression matrix metalloproteinases (MMPs) with reduced expression of tissue inhibitor of metalloproteinases (TIMPs) in rat stellate cell.
Life sciences 2004;74(18):2251-63.
2004: Kotaro Kawaguchi; Isao Sakaida; Masako Tsuchiya; Kaoru Omori; Taro Takami; Kiwamu Okita
Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet.
Biochemical and biophysical research communications 2004;315(1):187-95.
2004: Naoki Yamamoto; Shuji Terai; Shinya Ohata; Tomomi Watanabe; Kaoru Omori; Koh Shinoda; Koji Miyamoto; Toshiaki Katada; Isao Sakaida; Hiroshi Nishina; Kiwamu Okita
A subpopulation of bone marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver.
Biochemical and biophysical research communications 2004;313(4):1110-8.
2004: Sayaka Mori; Takahiro Yamasaki; Isao Sakaida; Taro Takami; Eiki Sakaguchi; Teruaki Kimura; Fumie Kurokawa; Shiro Maeyama; Kiwamu Okita
Hepatocellular carcinoma with nonalcoholic steatohepatitis.
Journal of gastroenterology 2004;39(4):391-6.
2003: Motonari Takashima; Yasuhiro Kuramitsu; Yuuichiro Yokoyama; Norio Iizuka; Toshifusa Toda; Isao Sakaida; Kiwamu Okita; Masaaki Oka; Kazuyuki Nakamura
Proteomic profiling of heat shock protein 70 family members as biomarkers for hepatitis C virus-related hepatocellular carcinoma.
Proteomics 2003;3(12):2487-93.
2003: Shuji Terai; Isao Sakaida; Naoki Yamamoto; Kaoru Omori; Tomomi Watanabe; Shinya Ohata; Toshiaki Katada; Koji Miyamoto; Koh Shinoda; Hiroshi Nishina; Kiwamu Okita
An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes.
Journal of biochemistry 2003;134(4):551-8.
2003: Isao Sakaida; Shen Jinhua; Koichi Uchida; Shuji Terai; Kiwamu Okita
Leptin receptor-deficient Zucker (fa/fa) rat retards the development of pig serum-induced liver fibrosis with Kupffer cell dysfunction.
Life sciences 2003;73(19):2491-501.
2003: Isao Sakaida; Masako Tsuchiya; Kotarou Kawaguchi; Teruaki Kimura; Shuji Terai; Kiwamu Okita
Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet.
Journal of hepatology 2003;38(6):762-9.
2003: Isao Sakaida; Koji Hironaka; Shuji Terai; Kiwamu Okita
Gadolinium chloride reverses dimethylnitrosamine (DMN)-induced rat liver fibrosis with increased matrix metalloproteinases (MMPs) of Kupffer cells.
Life sciences 2003;72(8):943-59.
2002: Shuji Terai; Naoki Yamamoto; Kaoru Omori; Isao Sakaida; Kiwamu Okita
A new cell therapy using bone marrow cells to repair damaged liver.
Journal of gastroenterology 2002;37 Suppl 14():162-3.
2002: Hitoshi Shirahashi; Isao Sakaida; Shuji Terai; Koji Hironaka; Noriyoshi Kusano; Kiwamu Okita
Ubiquitin is a possible new predictive marker for the recurrence of human hepatocellular carcinoma.
Liver 2002;22(5):413-8.
2002: Akiko Akazawa; Isao Sakaida; Shingo Higaki; Yoshitsugu Kubo; Koichi Uchida; Kiwamu Okita
Increased expression of tumor necrosis factor-alpha messenger RNA in the intestinal mucosa of inflammatory bowel disease, particularly in patients with disease in the inactive phase.
Journal of gastroenterology 2002;37(5):345-53.
2002: Kiwamu Okita; Isao Sakaida; Keisuke Hino
Current strategies for chemoprevention of hepatocellular carcinoma.
Oncology 2002;62 Suppl 1():24-8.
2001: Eiki Sakaguchi; Kozo Kayano; M Segawa; M Aoyagi; Isao Sakaida; Kiwamu Okita
[Th1/Th2 imbalance in HCV-related liver cirrhosis].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(7):1259-63.
2001: M Masuhara; T Yagawa; M Aoyagi; C Suzuki; Eiki Sakaguchi; M Segawa; Koji Hironaka; Kozo Kayano; Fusako Tamura; M Seguchi; Y Soejima; F Murakami; Isao Sakaida; A Tateishi; Y Fukumoto; Kiwamu Okita
HBV-related fulminant hepatic failure: successful intensive medical therapy in a candidate for liver transplantation.
Journal of gastroenterology 2001;36(5):350-3.
2001: C Suzuki; Kozo Kayano; Kazushige Uchida; Isao Sakaida; Kiwamu Okita
Characteristics of the cell proliferation profile of activated rat hepatic stellate cells in vitro in contrast to their fibrogenesis activity.
Journal of gastroenterology 2001;36(5):322-9.
2000: Kozo Kayano; Eiki Sakaguchi; Isao Sakaida; Kiwamu Okita
[Cytokines and liver fibrosis].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2000;23(6):611-2.
2000: Kazushige Uchida; Isao Sakaida; Koji Hironaka; Kozo Kayano; Kiwamu Okita
Preventive effect of FK 506 (tacrolimus hydrate) on experimentally induced acute liver injury in rats.
Digestive diseases and sciences 2000;45(10):1996-2001.
2000: Koji Hironaka; Isao Sakaida; Kazushige Uchida; Kiwamu Okita
Correlation between stellate cell activation and serum fibrosis markers in choline-deficient L-amino acid-defined diet-induced rat liver fibrosis.
Digestive diseases and sciences 2000;45(10):1935-43.
2000: Isao Sakaida; Koji Hironaka; Kazushige Uchida; Kiwamu Okita
Loss of inhibitory growth regulation by TGF-beta1 in preneoplastic lesions in rat liver.
Digestive diseases and sciences 2000;45(2):325-33.
2000: Koji Hironaka; Isao Sakaida; Y Matsumura; Seiji Kaino; Koji Miyamoto; Kiwamu Okita
Enhanced interstitial collagenase (matrix metalloproteinase-13) production of Kupffer cell by gadolinium chloride prevents pig serum-induced rat liver fibrosis.
Biochemical and biophysical research communications 2000;267(1):290-5.
2000: K Tanigawa; Isao Sakaida; M Masuhara; M Hagiya; Kiwamu Okita
Augmenter of liver regeneration (ALR) may promote liver regeneration by reducing natural killer (NK) cell activity in human liver diseases.
Journal of gastroenterology 2000;35(2):112-9.
1999: Isao Sakaida; Kazushige Uchida; Koji Hironaka; Kiwamu Okita
Prolyl 4-hydroxylase inhibitor (HOE 077) prevents TIMP-1 gene expression in rat liver fibrosis.
Journal of gastroenterology 1999;34(3):376-7.
1999: Isao Sakaida; Koji Hironaka; Kazushige Uchida; Kiwamu Okita
Iron chelator deferoxamine reduces preneoplastic lesions in liver induced by choline-deficient L-amino acid-defined diet in rats.
Digestive diseases and sciences 1999;44(3):560-9.
1999: Isao Sakaida; A Nagatomi; Koji Hironaka; K Uchida; Kiwamu Okita
Quantitative analysis of liver fibrosis and stellate cell changes in patients with chronic hepatitis C after interferon therapy.
The American journal of gastroenterology 1999;94(2):489-96.
1998: Isao Sakaida; Koji Hironaka; Kazushige Uchida; C Suzuki; Kozo Kayano; Kiwamu Okita
Fibrosis accelerates the development of enzyme-altered lesions in the rat liver.
Hepatology (Baltimore, Md.) 1998;28(5):1247-52.
1998: Kozo Kayano; Isao Sakaida; Kazushige Uchida; Kiwamu Okita
Inhibitory effects of the herbal medicine Sho-saiko-to (TJ-9) on cell proliferation and procollagen gene expressions in cultured rat hepatic stellate cells.
Journal of hepatology 1998;29(4):642-9.
1998: Fusako Tamura; A Masuhara; Isao Sakaida; E Fukumoto; T Nakamura; Kiwamu Okita
FK506 promotes liver regeneration by suppressing natural killer cell activity.
Journal of gastroenterology and hepatology 1998;13(7):703-8.
1998: K Takenaka; Isao Sakaida; M Yasunaga; Kiwamu Okita
Ultrastructural study of development of hepatic necrosis induced by TNF-alpha and D-galactosamine.
Digestive diseases and sciences 1998;43(4):887-92.
1998: Isao Sakaida; Kazushige Uchida; Y Matsumura; Kiwamu Okita
Interferon gamma treatment prevents procollagen gene expression without affecting transforming growth factor-beta1 expression in pig serum-induced rat liver fibrosis in vivo.
Journal of hepatology 1998;28(3):471-9.
1998: Isao Sakaida; Y Matsumura; S Akiyama; K Hayashi; A Ishige; Kiwamu Okita
Herbal medicine Sho-saiko-to (TJ-9) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet.
Journal of hepatology 1998;28(2):298-306.
1997: Y Matsumura; Isao Sakaida; Kazushige Uchida; Teruaki Kimura; T Ishihara; Kiwamu Okita
Prolyl 4-hydroxylase inhibitor (HOE 077) inhibits pig serum-induced rat liver fibrosis by preventing stellate cell activation.
Journal of hepatology 1997;27(1):185-92.
1997: S Wasaki; Isao Sakaida; Kazushige Uchida; T Kimura; Kozo Kayano; Kiwamu Okita
Preventive effect of cyclosporin A on experimentally induced acute liver injury in rats.
Liver 1997;17(2):107-14.
1997: A Nagatomi; Isao Sakaida; Y Matsumura; Kiwamu Okita
Cytoprotection by glycine against hypoxia-induced injury in cultured hepatocytes.
Liver 1997;17(2):57-62.
1997: T Kimura; Isao Sakaida; Shuji Terai; Y Matsumura; Koichi Uchida; Kiwamu Okita
Inhibition of tumor necrosis factor-alpha production retards liver regeneration after partial hepatectomy in rats.
Biochemical and biophysical research communications 1997;231(3):557-60.
1996: Isao Sakaida; A Nagatomi; Kiwamu Okita
Protection by glycine against chemical ischemia produced by cyanide in cultured hepatocytes.
Journal of gastroenterology 1996;31(5):684-90.
1996: M Masuhara; M Yasunaga; K Tanigawa; F Tamura; S Yamashita; Isao Sakaida; Kiwamu Okita
Expression of hepatocyte growth factor, transforming growth factor alpha, and transforming growth factor beta 1 messenger RNA in various human liver diseases and correlation with hepatocyte proliferation.
Hepatology (Baltimore, Md.) 1996;24(2):323-9.
1996: Isao Sakaida; Y Matsumura; M Kubota; Kozo Kayano; K Takenaka; Kiwamu Okita
The prolyl 4-hydroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expression in rat liver fibrosis induced by choline-deficient L-amino acid-defined diet.
Hepatology (Baltimore, Md.) 1996;23(4):755-63.
1995: Kozo Kayano; Isao Sakaida; M Kubota; M Yasunaga; Kiwamu Okita
Functional differences between activated and normal rat liver macrophages: LPS uptake capacity by flow cytometric analysis in contrast with TNF-alpha release.
Liver 1995;15(5):253-9.
1995: S Wasaki; Isao Sakaida; A Nagatomi; Y Matsumura; M Yasunaga; Kiwamu Okita
The effect of E3330 on active oxygen generation by isolated hepatic macrophages in rats.
Journal of gastroenterology 1995;30(2):273-4.
1995: Isao Sakaida; Kiwamu Okita
New prolyl 4-hydroxylase inhibitor reduces procollagen gene expression and enzyme-altered lesions in rat liver cirrhosis.
Journal of gastroenterology and hepatology 1995;10 Suppl 1():S63-4.
1995: Isao Sakaida; Kozo Kayano; S Wasaki; A Nagatomi; Y Matsumura; Kiwamu Okita
Protection against acetaminophen-induced liver injury in vivo by an iron chelator, deferoxamine.
Scandinavian journal of gastroenterology 1995;30(1):61-7.
1994: Isao Sakaida; M Kubota; Kozo Kayano; K Takenaka; Kazuhiro J Mori; Kiwamu Okita
Prevention of fibrosis reduces enzyme-altered lesions in the rat liver.
Carcinogenesis 1994;15(10):2201-6.
1992: Isao Sakaida; Kozo Kayano; M Kubota; Kazuhiro J Mori; K Takenaka; M Yasunaga; Kiwamu Okita
Protective effect of deferoxamine for acetaminophen induced liver injury.
Gastroenterologia Japonica 1992;27(3):426.
1992: Kozo Kayano; M Yasunaga; M Kubota; K Takenaka; Kazuhiro J Mori; A Yamashita; Y Kubo; Isao Sakaida; Kiwamu Okita; K Sanuki
Detection of proliferating hepatocytes by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) in patients with acute hepatic failure.
Liver 1992;12(3):132-6.