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Kei Sakamoto

Research Profile

Chemicals & Drugs

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Physiology

Anatomy

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Gene Knock In Techniques

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Publications

TOP 3
Saifeldin N Shehata; Frank Sicheri; Benjamin E Turk; Elton Zeqiraj; Roger W Hunter; Hua Jane Lou; Eriko Ohta; Mark Peggie; Kei Sakamoto
Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.
Emma Henriksson; Helena A Jones; Nicholas Morrice; Kashyap Patel; Mark Peggie; Kei Sakamoto; Olga Göransson
The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes.
Simon A Hawley; Bruce E Kemp; Kirsty J Mustard; Mark W Peggie; Fiona A Ross; Kei Sakamoto; Jonathan D Schertzer; Gregory R Steinberg; Katherine J Walker; Darya Zibrova; Cyrille Chevtzoff; Morgan D Fullerton; Kevin A Green; D Grahame Hardie
The ancient drug salicylate directly activates AMP-activated protein kinase.

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All Publications

2012: Saifeldin N Shehata; Frank Sicheri; Benjamin E Turk; Elton Zeqiraj; Roger W Hunter; Hua Jane Lou; Eriko Ohta; Mark Peggie; Kei Sakamoto
Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.
Cellular signalling 2012;24(11):2085-94.
2012: Emma Henriksson; Helena A Jones; Nicholas Morrice; Kashyap Patel; Mark Peggie; Kei Sakamoto; Olga Göransson
The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes.
The Biochemical journal 2012;444(3):503-14.
2012: Simon A Hawley; Bruce E Kemp; Kirsty J Mustard; Mark W Peggie; Fiona A Ross; Kei Sakamoto; Jonathan D Schertzer; Gregory R Steinberg; Katherine J Walker; Darya Zibrova; Cyrille Chevtzoff; Morgan D Fullerton; Kevin A Green; D Grahame Hardie
The ancient drug salicylate directly activates AMP-activated protein kinase.
Science (New York, N.Y.) 2012;336(6083):918-22.
2011: Laura R Pearce; Eeva M Sommer; Kei Sakamoto; Stephan Wullschleger; Dario R Alessi
Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.
The Biochemical journal 2011;436(1):169-79.
2011: Amélie Gormand; Emma Henriksson; Kristoffer Ström; Thomas Elbenhardt Jensen; Kei Sakamoto; Olga Göransson
Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes.
Journal of cellular biochemistry 2011;112(5):1364-75.
2011: Charlotte J Green; D Grahame Hardie; Katherine Macrae; Kei Sakamoto; Sarah Fogarty; Harinder S Hundal
Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase.
The Biochemical journal 2011;435(2):463-74.
2011: Ciaran Richardson; Kei Sakamoto; Paola de los Heros; Maria Deak; David G Campbell; Alan R Prescott; Dario R Alessi
Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.
Journal of cell science 2011;124(Pt 5):789-800.
2011: Stephan Wullschleger; David H Wasserman; Alex Gray; Kei Sakamoto; Dario R Alessi
Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis.
The Biochemical journal 2011;434(2):265-74.
2011: Shuai Chen; David H Wasserman; Carol MacKintosh; Kei Sakamoto
Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.
Cell metabolism 2011;13(1):68-79.
2011: Stephan Wullschleger; Kei Sakamoto; Lana Johnstone; Suzanne Duce; Stewart Fleming; Dario R Alessi
How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance.
Disease models & mechanisms 2011;4(1):95-103.
2010: Michale Bouskila; Roger W Hunter; Adel F M Ibrahim; Lucie Delattre; Mark Peggie; Janna A van Diepen; Peter J Voshol; Jørgen Jensen; Kei Sakamoto
Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle.
Cell metabolism 2010;12(5):456-66.
2008: Mhairi C Towler; Sarah Fogarty; Simon A Hawley; David A Pan; David M A Martin; Nick A Morrice; Afshan McCarthy; María N Galardo; Silvina B Meroni; Selva B Cigorraga; Alan Ashworth; Kei Sakamoto; D Grahame Hardie
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.
The Biochemical journal 2008;416(1):1-14.
2008: Kei Sakamoto; Geoffrey D Holman
Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic.
American journal of physiology. Endocrinology and metabolism 2008;295(1):E29-37.
2008: Xu Huang; Stephan Wullschleger; Natalia Shpiro; Victoria A McGuire; Kei Sakamoto; Yvonne L Woods; Wendy McBurnie; Stewart Fleming; Dario R Alessi
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice.
The Biochemical journal 2008;412(2):211-21.
2008: Jose R Bayascas; Stephan Wullschleger; Kei Sakamoto; Juan M García-Martínez; Carol Clacher; David Komander; Daan M F van Aalten; Krishna M Boini; Florian Lang; Christopher Lipina; Lisa Logie; Calum Sutherland; John A Chudek; Janna A van Diepen; Peter J Voshol; John M Lucocq; Dario R Alessi
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
Molecular and cellular biology 2008;28(10):3258-72.
2008: Kei Sakamoto
Silencing metabolic disorders by novel SIRT1 activators.
Cell metabolism 2008;7(1):3-4.
2007: Olga Göransson; Andrew McBride; Simon A Hawley; Fiona A Ross; Natalia Shpiro; Marc Foretz; Benoit Viollet; D Grahame Hardie; Kei Sakamoto
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.
The Journal of biological chemistry 2007;282(45):32549-60.
2006: Nikolaos Dimopoulos; Maria Watson; Kei Sakamoto; Harinder S Hundal
Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells.
The Biochemical journal 2006;399(3):473-81.
2006: Jose Ramon Bayascas; Kei Sakamoto; Laura J Armit; J Simon C Arthur; Dario R Alessi
Evaluation of approaches to generation of tissue-specific knock-in mice.
The Journal of biological chemistry 2006;281(39):28772-81.
2006: D Grahame Hardie; Kei Sakamoto
AMPK: a key sensor of fuel and energy status in skeletal muscle.
Physiology (Bethesda, Md.) 2006;21():48-60.
2006: Dario R Alessi; Kei Sakamoto; Jose Ramon Bayascas
LKB1-dependent signaling pathways.
Annual review of biochemistry 2006;75():137-63.
2005: Sophie Turban; Victoria A Beardmore; Julia M Carr; Kei Sakamoto; Eric Hajduch; J Simon C Arthur; Harinder S Hundal
Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle.
Diabetes 2005;54(11):3161-8.
2005: Alfonso Mora; Kei Sakamoto; Edward J McManus; Dario R Alessi
Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart.
FEBS letters 2005;579(17):3632-8.
2005: Kei Sakamoto; Afshan McCarthy; Darrin Smith; Kevin A Green; D Grahame Hardie; Alan Ashworth; Dario R Alessi
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.
The EMBO journal 2005;24(10):1810-20.
2005: Edward J McManus; Kei Sakamoto; Laura J Armit; Leah Ronaldson; Natalia Shpiro; Rodolfo Marquez; Dario R Alessi
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis.
The EMBO journal 2005;24(8):1571-83.
2004: Kei Sakamoto; Olga Göransson; D Grahame Hardie; Dario R Alessi
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.
American journal of physiology. Endocrinology and metabolism 2004;287(2):E310-7.