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Naoki Sakane

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Akihiro Kamikawa; Tatsuya Ishii; Kohei Shimada; Kennedy Makondo; Osamu Inanami; Naoki Sakane; Toshihide Yoshida; Masayuki Saito; Kazuhiro Kimura
Proinsulin C-peptide abrogates type-1 diabetes-induced increase of renal endothelial nitric oxide synthase in rats.
Akinori Kogure; Naoki Sakane; Yasuto Takakura; Tsunekazu Umekawa; Keiji Yoshioka; Hoyoku Nishino; Takayuki Yamamoto; Teruo Kawada; Toshikazu Yoshikawa; Toshihide Yoshida
Effects of caffeine on the uncoupling protein family in obese yellow KK mice.
Y Nakamura; I Nagase; A Asano; N Sasaki; Toshihide Yoshida; Tsunekazu Umekawa; Naoki Sakane; M Saito
Beta 3-adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse.

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All Publications

2008: Akihiro Kamikawa; Tatsuya Ishii; Kohei Shimada; Kennedy Makondo; Osamu Inanami; Naoki Sakane; Toshihide Yoshida; Masayuki Saito; Kazuhiro Kimura
Proinsulin C-peptide abrogates type-1 diabetes-induced increase of renal endothelial nitric oxide synthase in rats.
Diabetes/metabolism research and reviews 2008;24(4):331-8.
2002: Akinori Kogure; Naoki Sakane; Yasuto Takakura; Tsunekazu Umekawa; Keiji Yoshioka; Hoyoku Nishino; Takayuki Yamamoto; Teruo Kawada; Toshikazu Yoshikawa; Toshihide Yoshida
Effects of caffeine on the uncoupling protein family in obese yellow KK mice.
Clinical and experimental pharmacology & physiology 2002;29(5-6):391-4.
2001: Y Nakamura; I Nagase; A Asano; N Sasaki; Toshihide Yoshida; Tsunekazu Umekawa; Naoki Sakane; M Saito
Beta 3-adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2001;63(3):309-14.
2001: Toshihide Yoshida; Yasuto Takakura; Naoki Sakane
[The relationship between beta 3-adrenoceptor and regulation of body fat mass, and food intake].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(3):437-42.
1999: Toshihide Yoshida; Naoki Sakane; Tsunekazu Umekawa; Akinori Kogure; M Kondo; K Kumamoto; Teruo Kawada; I Nagase; M Saito
Nicotine induces uncoupling protein 1 in white adipose tissue of obese mice.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999;23(6):570-5.
1999: Tsunekazu Umekawa; Toshihide Yoshida; Naoki Sakane; Akinori Kogure; M Kondo; H Honjyo
Trp64Arg mutation of beta3-adrenoceptor gene deteriorates lipolysis induced by beta3-adrenoceptor agonist in human omental adipocytes.
Diabetes 1999;48(1):117-20.
1998: Naoki Sakane; T Yoshida; K Yoshioka; Y Nakamura; Tsunekazu Umekawa; Akinori Kogure; Y Takakura; M Kondo
Trp64Arg mutation of beta3-adrenoceptor gene is associated with diabetic nephropathy in Type II diabetes mellitus.
Diabetologia 1998;41(12):1533-4.
1998: Akinori Kogure; T Yoshida; Naoki Sakane; Tsunekazu Umekawa; Y Takakura; M Kondo
Synergic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on weight loss in obese Japanese.
Diabetologia 1998;41(11):1399.
1998: Naoki Sakane; Toshihide Yoshida; Tsunekazu Umekawa; Akinori Kogure; M Kondo; Y Nakamura; Y Sasaki; A Asano; M Saito
Acute and chronic regulation of ob mRNA levels by beta3-adrenoceptor agonists in obese Yellow KK mice.
Endocrine journal 1998;45(5):647-51.
1998: Naoki Sakane; T Yoshida; K Yoshioka; Tsunekazu Umekawa; Akinori Kogure; M Kondo
Trp64Arg mutation of beta3-adrenergic receptor and non-insulin dependent diabetes mellitus.
Internal medicine (Tokyo, Japan) 1998;37(3):345.
1998: Naoki Sakane; T Yoshida; Akinori Kogure; M Kondo
Different effects of acarbose and voglibose on serum 1,5-anhydroglucitol concentrations.
Diabetes care 1998;21(3):465-6.
1998: Toshihide Yoshida; Tsunekazu Umekawa; K Kumamoto; Naoki Sakane; Akinori Kogure; M Kondo; Y Wakabayashi; Teruo Kawada; I Nagase; M Saito
beta 3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers.
The American journal of physiology 1998;274(3 Pt 1):E469-75.
1997: Naoki Sakane; Toshihide Yoshida; Tsunekazu Umekawa; Akinori Kogure; Yasuto Takakura; M Kondo
Effects of Trp64Arg mutation in the beta 3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients.
Diabetes care 1997;20(12):1887-90.
1997: Naoki Sakane; Toshihide Yoshida; K Yoshioka; Y Nakamura; Tsunekazu Umekawa; Akinori Kogure; Yasuto Takakura; M Kondo
Beta 3-adrenoreceptor gene polymorphism: a newly identified risk factor for proliferative retinopathy in NIDDM patients.
Diabetes 1997;46(10):1633-6.
1997: Naoki Sakane; Toshihide Yoshida; A Shimatsu; Tsunekazu Umekawa; M Kondo
Octreotide and bromocriptine suppress thyroid hormone levels and thyroid nodule in an acromegalic patient with nontoxic autonomous goiter.
Endocrine journal 1997;44(2):305-10.
1997: Tsunekazu Umekawa; Toshihide Yoshida; Naoki Sakane; M Saito; K Kumamoto; M Kondo
Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat.
European journal of endocrinology / European Federation of Endocrine Societies 1997;136(4):429-37.
1997: Tsunekazu Umekawa; Toshihide Yoshida; Naoki Sakane; M Kondo
Effect of CL316,243, a highly specific beta(3)-adrenoceptor agonist, on lipolysis of epididymal, mesenteric and subcutaneous adipocytes in rats.
Endocrine journal 1997;44(1):181-5.
1997: Naoki Sakane; Toshihide Yoshida; Tsunekazu Umekawa; M Kondo; Y Sakai; T Takahashi
Beta 3-adrenergic-receptor polymorphism: a genetic marker for visceral fat obesity and the insulin resistance syndrome.
Diabetologia 1997;40(2):200-4.
1996: T Umekawa; T Yoshida; Naoki Sakane; M Kondo
A case of Sheehan's syndrome with delirium.
Psychiatry and clinical neurosciences 1996;50(6):327-30.
1996: Naoki Sakane; Toshihide Yoshida; K Yoshioka; Tsunekazu Umekawa; Yasuto Takakura; Akinori Kogure; M Kondo
Genetic variation in the beta 3-adrenergic receptor in Japanese NIDDM patients.
Diabetes care 1996;19(9):1034-5.
1996: Tsunekazu Umekawa; Toshihide Yoshida; Naoki Sakane; M Kondo
Effect of CL316,243, a highly specific beta 3-adrenoceptor agonist, on lipolysis of human and rat adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(8):394-6.
1996: I Nagase; Toshihide Yoshida; K Kumamoto; Tsunekazu Umekawa; Naoki Sakane; H Nikami; T Kawada; M Saito
Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist.
The Journal of clinical investigation 1996;97(12):2898-904.
1996: Toshihide Yoshida; Tsunekazu Umekawa; Y Wakabayashi; K Yoshimoto; Naoki Sakane; M Kondo
Anti-obesity and anti-diabetic effects of mazindol in yellow KK mice: its activating effect on brown adipose tissue thermogenesis.
Clinical and experimental pharmacology & physiology 1996;23(6-7):476-82.
1996: Toshihide Yoshida; Tsunekazu Umekawa; Naoki Sakane; K Yoshimoto; M Kondo
Effect of CL316,243, a highly specific beta3-adrenoceptor agonist, on sympathetic nervous system activity in mice.
Metabolism: clinical and experimental 1996;45(6):787-91.
1996: Naoki Sakane; Toshihide Yoshida; Tsunekazu Umekawa; R Miyazaki; M Kondo
Nephrogenic diabetes insipidus induced by lobenzarit disodium treatment in patients with rheumatoid arthritis.
Internal medicine (Tokyo, Japan) 1996;35(2):119-22.
1996: Toshihide Yoshida; A Shimatsu; Naoki Sakane; N Hizuka; R Horikawa; T Tanaka
Growth hormone (GH) secretory dynamics in a case of acromegalic gigantism associated with hyperprolactinemia: nonpulsatile secretion of GH may induce elevated insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 levels.
The Journal of clinical endocrinology and metabolism 1996;81(1):310-3.
1995: Toshihide Yoshida; Naoki Sakane; Y Wakabayashi; Tsunekazu Umekawa; M Kondo
Thermogenic, anti-obesity effects of bofu-tsusho-san in MSG-obese mice.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1995;19(10):717-22.
1995: Naoki Sakane; T Yoshida; T Umekawa; M Kondo; Y Nagoshi
A case of primary hyperparathyroidism that had been treated under a diagnosis of depression for 10 years.
Psychiatry and clinical neurosciences 1995;49(2):147-9.
1995: R Miyazaki; Toshihide Yoshida; Naoki Sakane; T Yasuda; Tsunekazu Umekawa; M Kondo; A Shimatsu; N Hizuka; T Sano
Acromegalic gigantism with low serum level of growth hormone and elevated serum insulin-like growth factor-I.
Internal medicine (Tokyo, Japan) 1995;34(3):183-7.
1995: Toshihide Yoshida; K Yoshioka; Naoki Sakane; Tsunekazu Umekawa; M Kondo
Probucol prevents the progression of fatty liver in MSG obese mice.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1995;103(2):119-22.
1994: Toshihide Yoshida; K Yoshioka; N Hiraoka; Tsunekazu Umekawa; Naoki Sakane; M Kondo
Effect of CL 316,243, a novel beta 3-adrenoceptor agonist, on insulin secretion in perfused mouse pancreas.
Endocrine journal 1994;41(6):671-5.
1994: Toshihide Yoshida; Tsunekazu Umekawa; Y Wakabayashi; Naoki Sakane; M Kondo
Mechanism of anti-obesity action of benidipine hydrochloride in mice.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1994;18(11):776-9.
1994: Toshihide Yoshida; Naoki Sakane; Y Wakabayashi; Tsunekazu Umekawa; M Kondo
Anti-obesity effect of CL 316,243, a highly specific beta 3-adrenoceptor agonist, in mice with monosodium-L-glutamate-induced obesity.
European journal of endocrinology / European Federation of Endocrine Societies 1994;131(1):97-102.
1994: Toshihide Yoshida; Naoki Sakane; Tsunekazu Umekawa; M Kondo
Relationship between basal metabolic rate, thermogenic response to caffeine, and body weight loss following combined low calorie and exercise treatment in obese women.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1994;18(5):345-50.
1994: Toshihide Yoshida; Naoki Sakane; Y Wakabayashi; K Yoshioka; Tsunekazu Umekawa; M Kondo
The alpha/beta-adrenergic receptor blocker arotinolol activates the thermogenesis of brown adipose tissue in monosodium-L-glutamate-induced obese mice.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1994;18(5):339-43.
1994: Toshihide Yoshida; Naoki Sakane; Y Wakabayashi; Tsunekazu Umekawa; M Kondo
Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist, in yellow KK mice.
Life sciences 1994;54(7):491-8.
1994: Toshihide Yoshida; Naoki Sakane; Tsunekazu Umekawa; M Kondo
Effect of nicotine on sympathetic nervous system activity of mice subjected to immobilization stress.
Physiology & behavior 1994;55(1):53-7.
1994: Toshihide Yoshida; Naoki Sakane; Tsunekazu Umekawa; K Yoshioka; M Kondo; Y Wakabayashi
Usefulness of mazindol in combined diet therapy consisting of a low-calorie diet and Optifast in severely obese women.
International journal of clinical pharmacology research 1994;14(4):125-32.
1992: K Hashiramoto; T Yoshida; Naoki Sakane; M Kondo; I Kitagawa; H Honjo
A case of testicular feminization syndrome with bulimia nervosa.
The Japanese journal of psychiatry and neurology 1992;46(1):107-12.