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Jeremy Saklatvala

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Fiona E Watt; Tonia L Vincent; Robin Wait; Athanasios Didangelos; Heba M Ismail; Matthew Peirce; Jeremy Saklatvala
Src and fibroblast growth factor 2 independently regulate signaling and gene expression induced by experimental injury to intact articular cartilage.
Annika Burleigh; Anastasios Chanalaris; Clare Driscoll; Matthew D Gardiner; Jeremy Saklatvala; Olga Boruc; Tonia L Vincent
Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.
Eugénie Joanny; Philip Kong; Jeremy Saklatvala; Qize Ding; Leyi Gong; Andrew R Clark
Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1.

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All Publications

2013: Fiona E Watt; Tonia L Vincent; Robin Wait; Athanasios Didangelos; Heba M Ismail; Matthew Peirce; Jeremy Saklatvala
Src and fibroblast growth factor 2 independently regulate signaling and gene expression induced by experimental injury to intact articular cartilage.
Arthritis and rheumatism 2013;65(2):397-407.
2012: Annika Burleigh; Anastasios Chanalaris; Clare Driscoll; Matthew D Gardiner; Jeremy Saklatvala; Olga Boruc; Tonia L Vincent
Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.
Arthritis and rheumatism 2012;64(7):2278-88.
2012: Eugénie Joanny; Philip Kong; Jeremy Saklatvala; Qize Ding; Leyi Gong; Andrew R Clark
Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1.
British journal of pharmacology 2012;165(4b):1124-36.
2012: Holger Buss; Katja Handschick; Nadine Jurrmann; Helmut Müller; Michael Naumann; Päivi M Ojala; Pirita Pekkonen; Jeremy Saklatvala; M Lienhard Schmitz; Robin Wait; Knut Beuerlein; Michael Kracht
Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression.
PloS one 2012;7(12):e51847.
2010: Francesco P Marchese; Anna Aubareda; Corina Tudor; Jeremy Saklatvala; Andrew R Clark; Jonathan L E Dean
MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment.
The Journal of biological chemistry 2010;285(36):27590-600.
2010: Carmen R Tchen; Joana R S Martins; Nasren Paktiawal; Roberta Perelli; Jeremy Saklatvala; Andrew R Clark
Glucocorticoid regulation of mouse and human dual specificity phosphatase 1 (DUSP1) genes: unusual cis-acting elements and unexpected evolutionary divergence.
The Journal of biological chemistry 2010;285(4):2642-52.
2009: Andrew R Clark; Jonathan L E Dean; Jeremy Saklatvala
The p38 MAPK pathway mediates both antiinflammatory and proinflammatory processes: comment on the article by Damjanov and the editorial by Genovese.
Arthritis and rheumatism 2009;60(11):3513-4.
2009: Shi-Lu Chia; Yasunobu Sawaji; Annika Burleigh; Celia McLean; Julia Inglis; Jeremy Saklatvala; Tonia L Vincent
Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.
Arthritis and rheumatism 2009;60(7):2019-27.
2009: Corina Tudor; Francesco P Marchese; Edward Hitti; Anna Aubareda; Lesley Rawlinson; Matthias Gaestel; Perry Blackshear; Andrew R Clark; Jeremy Saklatvala; Jonathan L E Dean
The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages.
FEBS letters 2009;583(12):1933-8.
2009: Andrew Clark; Jonathan Dean; Corina Tudor; Jeremy Saklatvala
Post-transcriptional gene regulation by MAP kinases via AU-rich elements.
Frontiers in bioscience : a journal and virtual library 2009;14():847-71.
2008: Yasunobu Sawaji; Judith Hynes; Tonia L Vincent; Jeremy Saklatvala
Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage.
Arthritis and rheumatism 2008;58(11):3498-509.
2008: Tonia L Vincent; Jeremy Saklatvala
Is the response of cartilage to injury relevant to osteoarthritis?
Arthritis and rheumatism 2008;58(5):1207-10.
2007: Susan Alexander; Fiona Watt; Yasunobu Sawaji; Monika Hermansson; Jeremy Saklatvala
Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.
Arthritis and rheumatism 2007;56(11):3715-25.
2007: Constantinos Brikos; Robin Wait; Shajna Begum; Luke A J O'Neill; Jeremy Saklatvala
Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components.
Molecular & cellular proteomics : MCP 2007;6(9):1551-9.
2007: T L Vincent; C J McLean; L E Full; David Peston; Jeremy Saklatvala
FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(7):752-63.
2007: Kate A Alford; Sarah Glennie; Bryony R Turrell; Lesley Rawlinson; Jeremy Saklatvala; Jonathan L E Dean
Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling.
The Journal of biological chemistry 2007;282(9):6232-41.
2007: Jeremy Saklatvala
Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis.
Current drug targets 2007;8(2):305-13.
2007: Matthew J Peirce; Jeremy Saklatvala; Andrew P Cope; Robin Wait
Mapping lymphocyte plasma membrane proteins: a proteomic approach.
Methods in molecular medicine 2007;136():361-7.
2007: Monika Hermansson; Jeremy Saklatvala; Robin Wait
Two-dimensional electrophoresis of proteins secreted from articular cartilage.
Methods in molecular medicine 2007;136():349-59.
2006: Sonya M Abraham; Toby Lawrence; Anna Kleiman; Paul Warden; Mino Medghalchi; Jan P Tuckermann; Jeremy Saklatvala; Andrew R Clark
Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.
The Journal of experimental medicine 2006;203(8):1883-9.
2006: T Vincent; Jeremy Saklatvala
Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage?
Biochemical Society transactions 2006;34(Pt 3):456-7.
2006: Matthew Brook; Carmen R Tchen; Tomas Santalucia; Joanne McIlrath; J Simon C Arthur; Jeremy Saklatvala; Andrew R Clark
Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways.
Molecular and cellular biology 2006;26(6):2408-18.
2005: Matthew J Peirce; Shajna Begum; Jeremy Saklatvala; Andrew P Cope; Robin Wait
Two-stage affinity purification for inducibly phosphorylated membrane proteins.
Proteomics 2005;5(9):2417-21.
2004: Monika Hermansson; Yasunobu Sawaji; Mark Bolton; Susan Alexander; Andrew Wallace; Shajna Begum; Robin Wait; Jeremy Saklatvala
Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.
The Journal of biological chemistry 2004;279(42):43514-21.
2004: Jonathan L E Dean; Gareth Sully; Andrew R Clark; Jeremy Saklatvala
The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.
Cellular signalling 2004;16(10):1113-21.
2004: Johann Gruber; Tonia L Vincent; Monika Hermansson; Mark Bolton; Robin Wait; Jeremy Saklatvala
Induction of interleukin-1 in articular cartilage by explantation and cutting.
Arthritis and rheumatism 2004;50(8):2539-46.
2004: Jeremy Saklatvala
The p38 MAP kinase pathway as a therapeutic target in inflammatory disease.
Current opinion in pharmacology 2004;4(4):372-7.
2004: Carmen R Tchen; Matthew Brook; Jeremy Saklatvala; Andrew R Clark
The stability of tristetraprolin mRNA is regulated by mitogen-activated protein kinase p38 and by tristetraprolin itself.
The Journal of biological chemistry 2004;279(31):32393-400.
2004: Tonia L Vincent; Monika Hermansson; Ulrich N Hansen; Andrew A Amis; Jeremy Saklatvala
Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded.
Arthritis and rheumatism 2004;50(2):526-33.
2004: Gareth Sully; Jonathan L E Dean; Robin Wait; Lesley Rawlinson; Tomas Santalucia; Jeremy Saklatvala; Andrew R Clark
Structural and functional dissection of a conserved destabilizing element of cyclo-oxygenase-2 mRNA: evidence against the involvement of AUF-1 [AU-rich element/poly(U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream-sequence-element-binding protein 1).
The Biochemical journal 2004;377(Pt 3):629-39.
2004: Jeremy Saklatvala; Hideaki Nagase
Report on the Molecular Approaches to Osteoarthritis Symposium, Imperial College London, UK, 18-20 April 2004.
Arthritis research & therapy 2004;6(5):203-7.
2004: Matthew J Peirce; Robin Wait; Shajna Begum; Jeremy Saklatvala; Andrew P Cope
Expression profiling of lymphocyte plasma membrane proteins.
Molecular & cellular proteomics : MCP 2004;3(1):56-65.
2003: Jonathan L E Dean; Simon J Sarsfield; Elizabeth Tsounakou; Jeremy Saklatvala
p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation.
The Journal of biological chemistry 2003;278(41):39470-6.
2003: Andrew R Clark; Jonathan L E Dean; Jeremy Saklatvala
Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38.
FEBS letters 2003;546(1):37-44.
2003: Jeremy Saklatvala; Jonathan Dean; Andrew Clark
Control of the expression of inflammatory response genes.
Biochemical Society symposium 2003;(70):95-106.
2003: Jeremy Saklatvala; Hideaki Nagase; Guy Salvesen
A tribute to Alan J. Barrett.
Biochemical Society symposium 2003;(70):ix-x.
2002: Michael Kracht; Jeremy Saklatvala
Transcriptional and post-transcriptional control of gene expression in inflammation.
Cytokine 2002;20(3):91-106.
2002: Marina Lasa; Sonya M Abraham; Christine Boucheron; Jeremy Saklatvala; Andrew R Clark
Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.
Molecular and cellular biology 2002;22(22):7802-11.
2002: Jonathan L E Dean; Gareth Sully; Robin Wait; Lesley Rawlinson; Andrew R Clark; Jeremy Saklatvala
Identification of a novel AU-rich-element-binding protein which is related to AUF1.
The Biochemical journal 2002;366(Pt 3):709-19.
2002: Tonia L Vincent; Monika Hermansson; Mark Bolton; Robin Wait; Jeremy Saklatvala
Basic FGF mediates an immediate response of articular cartilage to mechanical injury.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8259-64.
2002: Jeremy Saklatvala
Glucocorticoids: do we know how they work?
Arthritis research 2002;4(3):146-50.
2001: KR Mahtani; Matthew Brook; Jonathan L E Dean; Gareth Sully; Jeremy Saklatvala; Andrew R Clark
Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability.
Molecular and cellular biology 2001;21(19):6461-9.
2001: Marina Lasa; Matthew Brook; Jeremy Saklatvala; Andrew R Clark
Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38.
Molecular and cellular biology 2001;21(3):771-80.
2001: Jonathan L E Dean; Robin Wait; KR Mahtani; Gareth Sully; Andrew R Clark; Jeremy Saklatvala
The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR.
Molecular and cellular biology 2001;21(3):721-30.
2001: A Finch; W Davis; W G Carter; Jeremy Saklatvala
Analysis of mitogen-activated protein kinase pathways used by interleukin 1 in tissues in vivo: activation of hepatic c-Jun N-terminal kinases 1 and 2, and mitogen-activated protein kinase kinases 4 and 7.
The Biochemical journal 2001;353(Pt 2):275-81.
2000: Matthew Brook; Gareth Sully; Andrew R Clark; Jeremy Saklatvala
Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade.
FEBS letters 2000;483(1):57-61.
2000: Marina Lasa; KR Mahtani; A Finch; G Brewer; Jeremy Saklatvala; Andrew R Clark
Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade.
Molecular and cellular biology 2000;20(12):4265-74.
1999: Gillian W Cockerill; Jeremy Saklatvala; S H Ridley; Helen Yarwood; Norman E Miller; B Oral; S Nithyanathan; G Taylor; Dorian O Haskard
High-density lipoproteins differentially modulate cytokine-induced expression of E-selectin and cyclooxygenase-2.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(4):910-7.
1999: Jeremy Saklatvala; J Dean; A Finch
Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor.
Biochemical Society symposium 1999;64():63-77.
1999: Jonathan L E Dean; Matthew Brook; Andrew R Clark; Jeremy Saklatvala
p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes.
The Journal of biological chemistry 1999;274(1):264-9.
1998: S H Ridley; Jonathan L E Dean; Simon J Sarsfield; Matthew Brook; Andrew R Clark; Jeremy Saklatvala
A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA.
FEBS letters 1998;439(1-2):75-80.
1998: E Stylianou; Jeremy Saklatvala
Interleukin-1.
The international journal of biochemistry & cell biology 1998;30(10):1075-9.
1998: A Krause; Helmut Holtmann; S Eickemeier; Reinhard Winzen; Marta Szamel; Klaus Resch; Jeremy Saklatvala; Michael Kracht
Stress-activated protein kinase/Jun N-terminal kinase is required for interleukin (IL)-1-induced IL-6 and IL-8 gene expression in the human epidermal carcinoma cell line KB.
The Journal of biological chemistry 1998;273(37):23681-9.
1997: A Finch; P Holland; J Cooper; Jeremy Saklatvala; Michael Kracht
Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7.
FEBS letters 1997;418(1-2):144-8.
1997: François Guesdon; R J Waller; Jeremy Saklatvala
Specific detection of an interleukin 1- and tumour necrosis factor-activated beta-casein kinase in HeLa and KB cells.
Cytokine 1997;9(7):471-9.
1997: JB Crawley; Lesley Rawlinson; Ferdinand V Lali; T H Page; Jeremy Saklatvala; Brian M J Foxwell
T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation.
The Journal of biological chemistry 1997;272(23):15023-7.
1996: Jeremy Saklatvala; L Rawlinson; R J Waller; Simon J Sarsfield; J C Lee; L F Morton; Michael J Barnes; Richard W Farndale
Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue.
The Journal of biological chemistry 1996;271(12):6586-9.
1996: Jeremy Saklatvala; W Davis; François Guesdon
Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1336):151-7.
1995: François Guesdon; T Ikebe; E Stylianou; J Warwick-Davies; S Haskill; Jeremy Saklatvala
Interleukin 1-induced phosphorylation of MAD3, the major inhibitor of nuclear factor kappa B of HeLa cells. Interference in signalling by the proteinase inhibitors 3,4-dichloroisocoumarin and tosylphenylalanyl chloromethylketone.
The Biochemical journal 1995;307 ( Pt 1)():287-95.
1995: Jeremy Saklatvala
Intracellular signalling mechanisms of interleukin 1 and tumour necrosis factor: possible targets for therapy.
British medical bulletin 1995;51(2):402-18.
1994: François Guesdon; R J Waller; Jeremy Saklatvala
Specific activation of beta-casein kinase by the inflammatory cytokines interleukin 1 and tumour necrosis factor.
The Biochemical journal 1994;304 ( Pt 3)():761-8.
1994: M Kracht; O Truong; Nick Totty; M Shiroo; Jeremy Saklatvala
Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver.
The Journal of experimental medicine 1994;180(6):2017-25.
1994: Norman Freshney; L Rawlinson; François Guesdon; E Jones; S Cowley; J Hsuan; Jeremy Saklatvala
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.
Cell 1994;78(6):1039-49.
1994: M Kracht; M Shiroo; C J Marshall; J J Hsuan; Jeremy Saklatvala
Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669.
The Biochemical journal 1994;302 ( Pt 3)():897-905.
1994: H L Thompson; C J Marshall; Jeremy Saklatvala
Characterization of two different forms of mitogen-activated protein kinase kinase induced in polymorphonuclear leukocytes following stimulation by N-formylmethionyl-leucyl-phenylalanine or granulocyte-macrophage colony-stimulating factor.
The Journal of biological chemistry 1994;269(13):9486-92.
1993: Jeremy Saklatvala; L M Rawlinson; C J Marshall; M Kracht
Interleukin 1 and tumour necrosis factor activate the mitogen-activated protein (MAP) kinase kinase in cultured cells.
FEBS letters 1993;334(2):189-92.
1993: H L Thompson; M Shiroo; Jeremy Saklatvala
The chemotactic factor N-formylmethionyl-leucyl-phenylalanine activates microtubule-associated protein 2 (MAP) kinase and a MAP kinase kinase in polymorphonuclear leucocytes.
The Biochemical journal 1993;290 ( Pt 2)():483-8.
1993: François Guesdon; Norman Freshney; R J Waller; L Rawlinson; Jeremy Saklatvala
Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein.
The Journal of biological chemistry 1993;268(6):4236-43.
1992: E Stylianou; L A O'Neill; L Rawlinson; M R Edbrooke; P Woo; Jeremy Saklatvala
Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes.
The Journal of biological chemistry 1992;267(22):15836-41.
1992: L A O'Neill; T Ikebe; Simon J Sarsfield; Jeremy Saklatvala
The binding subunit of pertussis toxin inhibits IL-1 induction of IL-2 and prostaglandin production.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(2):474-9.
1992: Jeremy Saklatvala; François Guesdon
Interleukin 1 and tumor necrosis factor signal transduction mechanisms: potential targets for pharmacological control of inflammation.
The Journal of rheumatology. Supplement 1992;32():65-9; discussion 69-70.
1991: François Guesdon; Jeremy Saklatvala
Identification of a cytoplasmic protein kinase regulated by IL-1 that phosphorylates the small heat shock protein, hsp27.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(10):3402-7.
1991: Jeremy Saklatvala; P Kaur; François Guesdon
Phosphorylation of the small heat-shock protein is regulated by interleukin 1, tumour necrosis factor, growth factors, bradykinin and ATP.
The Biochemical journal 1991;277 ( Pt 3)():635-42.
1991: C D Richards; Joseph Rafferty; J J Reynolds; Jeremy Saklatvala
Porcine collagenase from synovial fibroblasts: cDNA sequence and modulation of expression of RNA in vitro by various cytokines.
Matrix (Stuttgart, Germany) 1991;11(3):161-7.
1991: Jeremy Saklatvala; François Guesdon
Interleukin 1 signal transduction.
Agents and actions. Supplements 1991;35():35-40.
1990: L A O'Neill; T A Bird; Jeremy Saklatvala
How does interleukin 1 activate cells? Interleukin 1 signal transduction.
Immunology today 1990;11(11):392-4.
1990: T A Bird; A Davies; S A Baldwin; Jeremy Saklatvala
Interleukin 1 stimulates hexose transport in fibroblasts by increasing the expression of glucose transporters.
The Journal of biological chemistry 1990;265(23):13578-83.
1990: L A O'Neill; T A Bird; A J Gearing; Jeremy Saklatvala
Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4).
The Journal of biological chemistry 1990;265(6):3146-52.
1990: T A Bird; Jeremy Saklatvala
Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.
The Journal of biological chemistry 1990;265(1):235-40.
1990: Jeremy Saklatvala; T A Bird; P Kaur; L A O'Neill
IL-1 signal transduction: evidence of activation of G protein and protein kinase.
Progress in clinical and biological research 1990;349():285-95.
1989: P Kaur; W J Welch; Jeremy Saklatvala
Interleukin 1 and tumour necrosis factor increase phosphorylation of the small heat shock protein. Effects in fibroblasts, Hep G2 and U937 cells.
FEBS letters 1989;258(2):269-73.
1989: T A Bird; Jeremy Saklatvala
IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(1):126-33.
1988: T A Bird; A J Gearing; Jeremy Saklatvala
Murine interleukin 1 receptor. Direct identification by ligand blotting and purification to homogeneity of an interleukin 1-binding glycoprotein.
The Journal of biological chemistry 1988;263(24):12063-9.
1988: T A Bird; A J Gearing; Jeremy Saklatvala
Studies on the murine interleukin-1 receptor.
Developments in biological standardization 1988;69():83-91.
1987: T A Bird; A J Gearing; Jeremy Saklatvala
Murine interleukin-1 receptor: differences in binding properties between fibroblastic and thymoma cells and evidence for a two-chain receptor model.
FEBS letters 1987;225(1-2):21-6.
1987: T A Bird; Jeremy Saklatvala
Studies on the fate of receptor-bound 125I-interleukin 1 beta in porcine synovial fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(1):92-7.
1986: T A Bird; Jeremy Saklatvala
Identification of a common class of high affinity receptors for both types of porcine interleukin-1 on connective tissue cells.
Nature 1986;324(6094):263-6.
1985: Jeremy Saklatvala; Simon J Sarsfield; Y Townsend
Pig interleukin 1. Purification of two immunologically different leukocyte proteins that cause cartilage resorption, lymphocyte activation, and fever.
The Journal of experimental medicine 1985;162(4):1208-22.
1984: Jeremy Saklatvala; L M Pilsworth; Simon J Sarsfield; Jelena Gavrilovic; J K Heath
Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein.
The Biochemical journal 1984;224(2):461-6.
1983: L M Pilsworth; Jeremy Saklatvala
The cartilage-resorbing protein catabolin is made by synovial fibroblasts and its production is increased by phorbol myristate acetate.
The Biochemical journal 1983;216(2):481-9.
1983: Jeremy Saklatvala; V A Curry; Simon J Sarsfield
Purification to homogeneity of pig leucocyte catabolin, a protein that causes cartilage resorption in vitro.
The Biochemical journal 1983;215(2):385-92.
1983: Jeremy Saklatvala; Simon J Sarsfield; L M Pilsworth
Characterization of proteins from human synovium and mononuclear leucocytes that induce resorption of cartilage proteoglycan in vitro.
The Biochemical journal 1983;209(2):337-44.
1982: Jeremy Saklatvala; Simon J Sarsfield
Lymphocytes induce resorption of cartilage by producing catabolin.
The Biochemical journal 1982;202(1):275-8.