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Thomas Sakmar

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
17
Siebert, Friedrich
11
Kazmi, Manija
10
Smith, Steven
10
Seibert, Christoph
10
Fahmy, Karim
8
Khorana, Gobind
7
Marin, Ethan
7
Huber, Thomas
7
Yan, Elsa
7
Unson, Cecilia
6
Szundi, Istvan
6
Han, M
6
Lewis, James
6
Kliger, David
6
Mathies, Richard

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Publications

TOP 3
Kapoor Neeraj; Menon Santosh T; Chauhan Radha; Sachdev Pallavi; Sakmar Thomas P
Structural evidence for a sequential release mechanism for activation of heterotrimeric g proteins.
Ye Shixin; Huber Thomas; Vogel Reiner; Sakmar Thomas P
FTIR analysis of GPCR activation using azido probes.
Ahuja Shivani; Hornak Viktor; Yan Elsa C Y; Syrett Natalie; Goncalves Joseph A; Hirshfeld Amiram; Ziliox Martine; Sakmar Thomas P; Sheves Mordechai; Reeves Philip J; Smith Steven O; Eilers Markus
Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation.

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All Publications

2009: Kapoor Neeraj; Menon Santosh T; Chauhan Radha; Sachdev Pallavi; Sakmar Thomas P
Structural evidence for a sequential release mechanism for activation of heterotrimeric g proteins.
Journal of molecular biology 2009;393(4):882-97.
2009: Ye Shixin; Huber Thomas; Vogel Reiner; Sakmar Thomas P
FTIR analysis of GPCR activation using azido probes.
Nature chemical biology 2009;5(6):397-9.
2009: Ahuja Shivani; Hornak Viktor; Yan Elsa C Y; Syrett Natalie; Goncalves Joseph A; Hirshfeld Amiram; Ziliox Martine; Sakmar Thomas P; Sheves Mordechai; Reeves Philip J; Smith Steven O; Eilers Markus
Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation.
Nature structural & molecular biology 2009;16(2):168-75.
2008: Seibert Christoph; Veldkamp Christopher T; Peterson Francis C; Chait Brian T; Volkman Brian F; Sakmar Thomas P
Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases.
Biochemistry 2008;47(43):11251-62.
2008: Huber Thomas; Menon Santosh; Sakmar Thomas P
Structural basis for ligand binding and specificity in adrenergic receptors: implications for GPCR-targeted drug discovery.
Biochemistry 2008;47(42):11013-23.
2008: Vogel Reiner; Mahalingam Mohana; Lüdeke Steffen; Huber Thomas; Siebert Friedrich; Sakmar Thomas P
Functional role of the "ionic lock"--an interhelical hydrogen-bond network in family A heptahelical receptors.
Journal of molecular biology 2008;380(4):648-55.
2008: Huber Thomas; Sakmar Thomas P
Rhodopsin's active state is frozen like a DEER in the headlights.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(21):7343-4.
2008: Banerjee Sourabh; Huber Thomas; Sakmar Thomas P
Rapid incorporation of functional rhodopsin into nanoscale apolipoprotein bound bilayer (NABB) particles.
Journal of molecular biology 2008;377(4):1067-81.
2008: Louis Matthieu; Huber Thomas; Benton Richard; Sakmar Thomas P; Vosshall Leslie B
Bilateral olfactory sensory input enhances chemotaxis behavior.
Nature neuroscience 2008;11(2):187-99.
2008: Ye Shixin; Köhrer Caroline; Huber Thomas; Kazmi Manija; Sachdev Pallavi; Yan Elsa C Y; Bhagat Aditi; RajBhandary Uttam L; Sakmar Thomas P
Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis.
The Journal of biological chemistry 2008;283(3):1525-33.
2008: Veldkamp Christopher T; Seibert Christoph; Peterson Francis C; De la Cruz Norberto B; Haugner John C; Basnet Harihar; Sakmar Thomas P; Volkman Brian F
Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12.
Science signaling 2008;1(37):ra4.
2008: Seibert Christoph; Sakmar Thomas P
Toward a framework for sulfoproteomics: Synthesis and characterization of sulfotyrosine-containing peptides.
Biopolymers 2008;90(3):459-77.
2007: Janz Jay M; Sakmar Thomas P; Min K Christopher
A novel interaction between atrophin-interacting protein 4 and beta-p21-activated kinase-interactive exchange factor is mediated by an SH3 domain.
The Journal of biological chemistry 2007;282(39):28893-903.
2007: Periole Xavier; Huber Thomas; Marrink Siewert-Jan; Sakmar Thomas P
G protein-coupled receptors self-assemble in dynamics simulations of model bilayers.
Journal of the American Chemical Society 2007;129(33):10126-32.
2007: Sachdev Pallavi; Menon Santosh; Kastner David B; Chuang Jen-Zen; Yeh Ting-Yu; Conde Cecilia; Caceres Alfredo; Sung Ching-Hwa; Sakmar Thomas P
G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth.
The EMBO journal 2007;26(11):2621-32.
2007: Vogel Reiner; Sakmar Thomas P; Sheves Mordechai; Siebert Friedrich
Coupling of protonation switches during rhodopsin activation.
Photochemistry and photobiology 2007;83(2):286-92.
2006: Botelho Ana Vitória; Huber Thomas; Sakmar Thomas P; Brown Michael F
Curvature and hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes.
Biophysical journal 2006;91(12):4464-77.
2006: Vogel Reiner; Siebert Friedrich; Yan Elsa C Y; Sakmar Thomas P; Hirshfeld Amiram; Sheves Mordechai
Modulating rhodopsin receptor activation by altering the pKa of the retinal Schiff base.
Journal of the American Chemical Society 2006;128(32):10503-12.
2006: Sakmar Thomas P
Timing is everything: Direct measurement of retinol production in cones and rods.
The Journal of general physiology 2006;128(2):147-8.
2006: Veldkamp Christopher T; Seibert Christoph; Peterson Francis C; Sakmar Thomas P; Volkman Brian F
Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12).
Journal of molecular biology 2006;359(5):1400-9.
2006: Lewis James W; Szundi Istvan; Kazmi Manija A; Sakmar Thomas P; Kliger David S
Proton movement and photointermediate kinetics in rhodopsin mutants.
Biochemistry 2006;45(17):5430-9.
2006: Seibert Christoph; Ying Weiwen; Gavrilov Svetlana; Tsamis Fotini; Kuhmann Shawn E; Palani Anandan; Tagat Jayaram R; Clader John W; McCombie Stuart W; Baroudy Bahige M; Smith Steven O; Dragic Tatjana; Moore John P; Sakmar Thomas P
Interaction of small molecule inhibitors of HIV-1 entry with CCR5.
Virology 2006;349(1):41-54.
2006: Hoelz André; Janz Jay M; Lawrie Steven D; Corwin Brian; Lee Adrian; Sakmar Thomas P
Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2.
Journal of molecular biology 2006;358(2):509-22.
2006: Su Chih-Ying; Luo Dong-Gen; Terakita Akihisa; Shichida Yoshinori; Liao Hsi-Wen; Kazmi Manija A; Sakmar Thomas P; Yau King-Wai
Parietal-eye phototransduction components and their potential evolutionary implications.
Science (New York, N.Y.) 2006;311(5767):1617-21.
2006: Vogel Reiner; Lüdeke Steffen; Siebert Friedrich; Sakmar Thomas P; Hirshfeld Amiram; Sheves Mordechai
Agonists and partial agonists of rhodopsin: retinal polyene methylation affects receptor activation.
Biochemistry 2006;45(6):1640-52.
2005: Lüdeke Steffen; Beck Mareike; Yan Elsa C Y; Sakmar Thomas P; Siebert Friedrich; Vogel Reiner
The role of Glu181 in the photoactivation of rhodopsin.
Journal of molecular biology 2005;353(2):345-56.
2004: Lewis James W; Szundi Istvan; Kazmi Manija A; Sakmar Thomas P; Kliger David S
Time-resolved photointermediate changes in rhodopsin glutamic acid 181 mutants.
Biochemistry 2004;43(39):12614-21.
2004: Yan Elsa C Y; Ganim Ziad; Kazmi Manija A; Chang Belinda S W; Sakmar Thomas P; Mathies Richard A
Resonance Raman analysis of the mechanism of energy storage and chromophore distortion in the primary visual photoproduct.
Biochemistry 2004;43(34):10867-76.
2004: Billick Erika; Seibert Christoph; Pugach Pavel; Ketas Tom; Trkola Alexandra; Endres Michael J; Murgolo Nicholas J; Coates Elizabeth; Reyes Gregory R; Baroudy Bahige M; Sakmar Thomas P; Moore John P; Kuhmann Shawn E
The differential sensitivity of human and rhesus macaque CCR5 to small-molecule inhibitors of human immunodeficiency virus type 1 entry is explained by a single amino acid difference and suggests a mechanism of action for these inhibitors.
Journal of virology 2004;78(8):4134-44.
2004: Seibert Christoph; Sakmar Thomas P
Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs.
Current pharmaceutical design 2004;10(17):2041-62.
2003: Yan Elsa C Y; Kazmi Manija A; Ganim Ziad; Hou Jian-Min; Pan Douhai; Chang Belinda S W; Sakmar Thomas P; Mathies Richard A
Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9262-7.
2003: Tsamis Fotini; Gavrilov Svetlana; Kajumo Francis; Seibert Christoph; Kuhmann Shawn; Ketas Tom; Trkola Alexandra; Palani Anadan; Clader John W; Tagat Jayaram R; McCombie Stuart; Baroudy Bahige; Moore John P; Sakmar Thomas P; Dragic Tatjana
Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.
Journal of virology 2003;77(9):5201-8.
2002: Unson Cecilia G; Wu Cui-Rong; Jiang Youwei; Yoo Barney; Cheung Connie; Sakmar Thomas P; Merrifield R B
Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling.
Biochemistry 2002;41(39):11795-803.
2002: Chang Belinda S W; Jönsson Karolina; Kazmi Manija A; Donoghue Michael J; Sakmar Thomas P
Recreating a functional ancestral archosaur visual pigment.
Molecular biology and evolution 2002;19(9):1483-9.
2002: Seibert Christoph; Cadene Martine; Sanfiz Anthony; Chait Brian T; Sakmar Thomas P
Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11031-6.
2002: De Soma; Sakmar Thomas P
Interaction of A2E with model membranes. Implications to the pathogenesis of age-related macular degeneration.
The Journal of general physiology 2002;120(2):147-57.
2002: Krishna A Gopala; Menon Santosh T; Terry Tracy J; Sakmar Thomas P
Evidence that helix 8 of rhodopsin acts as a membrane-dependent conformational switch.
Biochemistry 2002;41(26):8298-309.
2002: Marin Ethan P; Krishna A Gopala; Sakmar Thomas P
Disruption of the alpha5 helix of transducin impairs rhodopsin-catalyzed nucleotide exchange.
Biochemistry 2002;41(22):6988-94.
2002: Sakmar Thomas P
Structure of rhodopsin and the superfamily of seven-helical receptors: the same and not the same.
Current opinion in cell biology 2002;14(2):189-95.
2002: Yan Elsa C Y; Kazmi Manija A; De Soma; Chang Belinda S W; Seibert Christoph; Marin Ethan P; Mathies Richard A; Sakmar Thomas P
Function of extracellular loop 2 in rhodopsin: glutamic acid 181 modulates stability and absorption wavelength of metarhodopsin II.
Biochemistry 2002;41(11):3620-7.
2002: Sakmar Thomas P; Menon Santosh T; Marin Ethan P; Awad Elias S
Rhodopsin: insights from recent structural studies.
Annual review of biophysics and biomolecular structure 2002;31():443-84.
2002: Chang Belinda S; Kazmi Manija A; Sakmar Thomas P
Synthetic gene technology: applications to ancestral gene reconstruction and structure-function studies of receptors.
Methods in enzymology 2002;343():274-94.
2001: Menon S T; Han M; Sakmar T P
Rhodopsin: structural basis of molecular physiology.
Physiological reviews 2001;81(4):1659-88.
2001: Jiang Y; Cypess A M; Muse E D; Wu C R; Unson C G; Merrifield R B; Sakmar T P
Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10102-7.
2001: Marin E P; Krishna A G; Sakmar T P
Rapid activation of transducin by mutations distant from the nucleotide-binding site: evidence for a mechanistic model of receptor-catalyzed nucleotide exchange by G proteins.
The Journal of biological chemistry 2001;276(29):27400-5.
2001: Marin E P; Krishna A G; Archambault V; Simuni E; Fu W Y; Sakmar T P
The function of interdomain interactions in controlling nucleotide exchange rates in transducin.
The Journal of biological chemistry 2001;276(26):23873-80.
2000: Isele J; Sakmar T P; Siebert F
Rhodopsin activation affects the environment of specific neighboring phospholipids: an FTIR spectroscopic study.
Biophysical journal 2000;79(6):3063-71.
2000: Min K C; Gravina S A; Sakmar T P
Reconstitution of the vertebrate visual cascade using recombinant heterotrimeric transducin purified from Sf9 cells.
Protein expression and purification 2000;20(3):514-26.
2000: Fahmy K; Sakmar T P; Siebert F
Transducin-dependent protonation of glutamic acid 134 in rhodopsin.
Biochemistry 2000;39(34):10607-12.
2000: Unson C G; Wu C R; Sakmar T P; Merrifield R B
Selective stabilization of the high affinity binding conformation of glucagon receptor by the long splice variant of Galpha(s).
The Journal of biological chemistry 2000;275(28):21631-8.
2000: Cormier E G; Persuh M; Thompson D A; Lin S W; Sakmar T P; Olson W C; Dragic T
Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5762-7.
2000: Dragic T; Trkola A; Thompson D A; Cormier E G; Kajumo F A; Maxwell E; Lin S W; Ying W; Smith S O; Sakmar T P; Moore J P
A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5639-44.
2000: Kazmi M A; Snyder L A; Cypess A M; Graber S G; Sakmar T P
Selective reconstitution of human D4 dopamine receptor variants with Gi alpha subtypes.
Biochemistry 2000;39(13):3734-44.
2000: Lewis J W; Szundi I; Fu W Y; Sakmar T P; Kliger D S
pH dependence of photolysis intermediates in the photoactivation of rhodopsin mutant E113Q.
Biochemistry 2000;39(3):599-606.
2000: Ernst O P; Meyer C K; Marin E P; Henklein P; Fu W Y; Sakmar T P; Hofmann K P
Mutation of the fourth cytoplasmic loop of rhodopsin affects binding of transducin and peptides derived from the carboxyl-terminal sequences of transducin alpha and gamma subunits.
The Journal of biological chemistry 2000;275(3):1937-43.
2000: Marin E P; Krishna A G; Zvyaga T A; Isele J; Siebert F; Sakmar T P
The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction.
The Journal of biological chemistry 2000;275(3):1930-6.
2000: Han M; Sakmar T P
Assays for activation of recombinant expressed opsins by all-trans-retinals.
Methods in enzymology 2000;315():251-67.
2000: Fahmy K; Sakmar T P; Siebert F
Structural determinants of active state conformation of rhodopsin: molecular biophysics approaches.
Methods in enzymology 2000;315():178-96.
2000: Lin S W; Han M; Sakmar T P
Analysis of functional microdomains of rhodopsin.
Methods in enzymology 2000;315():116-30.
1999: Simpson M M; Ballesteros J A; Chiappa V; Chen J; Suehiro M; Hartman D S; Godel T; Snyder L A; Sakmar T P; Javitch J A
Dopamine D4/D2 receptor selectivity is determined by A divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments.
Molecular pharmacology 1999;56(6):1116-26.
1999: Sakmar T P
Rhodopsin early receptor potential revisited.
Biophysical journal 1999;77(3):1189-91.
1999: Kochendoerfer G G; Lin S W; Sakmar T P; Mathies R A
How color visual pigments are tuned.
Trends in biochemical sciences 1999;24(8):300-5.
1999: Cypess A M; Unson C G; Wu C R; Sakmar T P
Two cytoplasmic loops of the glucagon receptor are required to elevate cAMP or intracellular calcium.
The Journal of biological chemistry 1999;274(27):19455-64.
1999: Lin S W; Sakmar T P
Colour tuning mechanisms of visual pigments.
Novartis Foundation symposium 1999;224():124-35; discussion 135-41, 181-90.
1998: Beck M; Siebert F; Sakmar T P
Evidence for the specific interaction of a lipid molecule with rhodopsin which is altered in the transition to the active state metarhodopsin II.
FEBS letters 1998;436(3):304-8.
1998: Lin S W; Kochendoerfer G G; Carroll K S; Wang D; Mathies R A; Sakmar T P
Mechanisms of spectral tuning in blue cone visual pigments. Visible and raman spectroscopy of blue-shifted rhodopsin mutants.
The Journal of biological chemistry 1998;273(38):24583-91.
1998: Han M; Smith S O; Sakmar T P
Constitutive activation of opsin by mutation of methionine 257 on transmembrane helix 6.
Biochemistry 1998;37(22):8253-61.
1998: Beck M; Sakmar T P; Siebert F
Spectroscopic evidence for interaction between transmembrane helices 3 and 5 in rhodopsin.
Biochemistry 1998;37(20):7630-9.
1998: Donzella G A; Schols D; Lin S W; Esté J A; Nagashima K A; Maddon P J; Allaway G P; Sakmar T P; Henson G; De Clercq E; Moore J P
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.
Nature medicine 1998;4(1):72-7.
1998: Han M; Groesbeek M; Smith S O; Sakmar T P
Role of the C9 methyl group in rhodopsin activation: characterization of mutant opsins with the artificial chromophore 11-cis-9-demethylretinal.
Biochemistry 1998;37(2):538-45.
1998: Dragic T; Trkola A; Lin S W; Nagashima K A; Kajumo F; Zhao L; Olson W C; Wu L; Mackay C R; Allaway G P; Sakmar T P; Moore J P; Maddon P J
Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry.
Journal of virology 1998;72(1):279-85.
1998: Sakmar T P
Rhodopsin: a prototypical G protein-coupled receptor.
Progress in nucleic acid research and molecular biology 1998;59():1-34.
1997: Han M; Groesbeek M; Sakmar T P; Smith S O
The C9 methyl group of retinal interacts with glycine-121 in rhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13442-7.
1997: Jäger S; Han M; Lewis J W; Szundi I; Sakmar T P; Kliger D S
Properties of early photolysis intermediates of rhodopsin are affected by glycine 121 and phenylalanine 261.
Biochemistry 1997;36(39):11804-10.
1997: Han M; Lou J; Nakanishi K; Sakmar T P; Smith S O
Partial agonist activity of 11-cis-retinal in rhodopsin mutants.
The Journal of biological chemistry 1997;272(37):23081-5.
1997: Jäger S; Lewis J W; Zvyaga T A; Szundi I; Sakmar T P; Kliger D S
Chromophore structural changes in rhodopsin from nanoseconds to microseconds following pigment photolysis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8557-62.
1997: Shieh T; Han M; Sakmar T P; Smith S O
The steric trigger in rhodopsin activation.
Journal of molecular biology 1997;269(3):373-84.
1997: Kazmi M A; Sakmar T P; Ostrer H
Mutation of a conserved cysteine in the X-linked cone opsins causes color vision deficiencies by disrupting protein folding and stability.
Investigative ophthalmology & visual science 1997;38(6):1074-81.
1997: Jäger S; Lewis J W; Zvyaga T A; Szundi I; Sakmar T P; Kliger D S
Time-resolved spectroscopy of the early photolysis intermediates of rhodopsin Schiff base counterion mutants.
Biochemistry 1997;36(8):1999-2009.
1996: Han M; Lin S W; Minkova M; Smith S O; Sakmar T P
Functional interaction of transmembrane helices 3 and 6 in rhodopsin. Replacement of phenylalanine 261 by alanine causes reversion of phenotype of a glycine 121 replacement mutant.
The Journal of biological chemistry 1996;271(50):32337-42.
1996: Han M; Lin S W; Smith S O; Sakmar T P
The effects of amino acid replacements of glycine 121 on transmembrane helix 3 of rhodopsin.
The Journal of biological chemistry 1996;271(50):32330-6.
1996: Fahmy K; Zvyaga T A; Sakmar T P; Siebert F
Spectroscopic evidence for altered chromophore--protein interactions in low-temperature photoproducts of the visual pigment responsible for congenital night blindness.
Biochemistry 1996;35(47):15065-73.
1996: Sheikh S P; Zvyaga T A; Lichtarge O; Sakmar T P; Bourne H R
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.
Nature 1996;383(6598):347-50.
1996: Lin S W; Sakmar T P
Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state.
Biochemistry 1996;35(34):11149-59.
1996: Zvyaga T A; Fahmy K; Siebert F; Sakmar T P
Characterization of the mutant visual pigment responsible for congenital night blindness: a biochemical and Fourier-transform infrared spectroscopy study.
Biochemistry 1996;35(23):7536-45.
1996: Unson C G; Cypess A M; Wu C R; Goldsmith P K; Merrifield R B; Sakmar T P
Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):310-5.
1995: Unson C G; Cypess A M; Kim H N; Goldsmith P K; Carruthers C J; Merrifield R B; Sakmar T P
Characterization of deletion and truncation mutants of the rat glucagon receptor. Seven transmembrane segments are necessary for receptor transport to the plasma membrane and glucagon binding.
The Journal of biological chemistry 1995;270(46):27720-7.
1995: Fahmy K; Siebert F; Sakmar T P
Photoactivated state of rhodopsin and how it can form.
Biophysical chemistry 1995;56(1-2):171-81.
1995: Garcia P D; Onrust R; Bell S M; Sakmar T P; Bourne H R
Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells.
The EMBO journal 1995;14(18):4460-9.
1995: Ernst O P; Hofmann K P; Sakmar T P
Characterization of rhodopsin mutants that bind transducin but fail to induce GTP nucleotide uptake. Classification of mutant pigments by fluorescence, nucleotide release, and flash-induced light-scattering assays.
The Journal of biological chemistry 1995;270(18):10580-6.
1994: Carruthers C J; Unson C G; Kim H N; Sakmar T P
Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding.
The Journal of biological chemistry 1994;269(46):29321-8.
1994: Fahmy K; Siebert F; Sakmar T P
A mutant rhodopsin photoproduct with a protonated Schiff base displays an active-state conformation: a Fourier-transform infrared spectroscopy study.
Biochemistry 1994;33(46):13700-5.
1994: Arnis S; Fahmy K; Hofmann K P; Sakmar T P
A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin.
The Journal of biological chemistry 1994;269(39):23879-81.
1994: Jäger F; Fahmy K; Sakmar T P; Siebert F
Identification of glutamic acid 113 as the Schiff base proton acceptor in the metarhodopsin II photointermediate of rhodopsin.
Biochemistry 1994;33(36):10878-82.
1994: Zvyaga T A; Fahmy K; Sakmar T P
Characterization of rhodopsin-transducin interaction: a mutant rhodopsin photoproduct with a protonated Schiff base activates transducin.
Biochemistry 1994;33(32):9753-61.
1993: Fahmy K; Jäger F; Beck M; Zvyaga T A; Sakmar T P; Siebert F
Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10206-10.
1993: Fahmy K; Sakmar T P
Light-dependent transducin activation by an ultraviolet-absorbing rhodopsin mutant.
Biochemistry 1993;32(35):9165-71.
1993: Fahmy K; Sakmar T P
Regulation of the rhodopsin-transducin interaction by a highly conserved carboxylic acid group.
Biochemistry 1993;32(28):7229-36.
1993: Min K C; Zvyaga T A; Cypess A M; Sakmar T P
Characterization of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Mutations on the cytoplasmic surface affect transducin activation.
The Journal of biological chemistry 1993;268(13):9400-4.
1993: Zvyaga T A; Min K C; Beck M; Sakmar T P
Movement of the retinylidene Schiff base counterion in rhodopsin by one helix turn reverses the pH dependence of the metarhodopsin I to metarhodopsin II transition.
The Journal of biological chemistry 1993;268(7):4661-7.
1992: Franke R R; Sakmar T P; Graham R M; Khorana H G
Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin.
The Journal of biological chemistry 1992;267(21):14767-74.
1992: Lin S W; Sakmar T P; Franke R R; Khorana H G; Mathies R A
Resonance Raman microprobe spectroscopy of rhodopsin mutants: effect of substitutions in the third transmembrane helix.
Biochemistry 1992;31(22):5105-11.
1992: Chan T; Lee M; Sakmar T P
Introduction of hydroxyl-bearing amino acids causes bathochromic spectral shifts in rhodopsin. Amino acid substitutions responsible for red-green color pigment spectral tuning.
The Journal of biological chemistry 1992;267(14):9478-80.
1991: Sakmar T P; Franke R R; Khorana H G
The role of the retinylidene Schiff base counterion in rhodopsin in determining wavelength absorbance and Schiff base pKa.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3079-83.
1990: Franke R R; König B; Sakmar T P; Khorana H G; Hofmann K P
Rhodopsin mutants that bind but fail to activate transducin.
Science (New York, N.Y.) 1990;250(4977):123-5.
1989: Sakmar T P; Franke R R; Khorana H G
Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8309-13.
1988: Karnik S S; Sakmar T P; Chen H B; Khorana H G
Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8459-63.
1988: Sakmar T P; Khorana H G
Total synthesis and expression of a gene for the alpha-subunit of bovine rod outer segment guanine nucleotide-binding protein (transducin).
Nucleic acids research 1988;16(14A):6361-72.
1988: Franke R R; Sakmar T P; Oprian D D; Khorana H G
A single amino acid substitution in rhodopsin (lysine 248----leucine) prevents activation of transducin.
The Journal of biological chemistry 1988;263(5):2119-22.

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