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Olli Saksela

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Anatomy

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Miao Yin; Tiina Jahkola; Olli Saksela; Johanna Soikkeli; Susanna Virolainen; Erkki Hölttä
TGF-β signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells.
Pirjo Nummela; Olli Saksela; Johanna Soikkeli; Pirjo Laakkonen; Johanna Lammi; Erkki Hölttä
Transforming growth factor beta-induced (TGFBI) is an anti-adhesive protein regulating the invasive growth of melanoma cells.
Pilvi Maliniemi; Kirsi Niiranen; Kristian Ovaska; Emilia Carlsson; Sampsa Hautaniemi; Leila Jeskanen; Anna Kaukola; Olli Saksela; Annamari Ranki
NAV3 copy number changes and target genes in basal and squamous cell cancers.

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All Publications

2012: Miao Yin; Tiina Jahkola; Olli Saksela; Johanna Soikkeli; Susanna Virolainen; Erkki Hölttä
TGF-β signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells.
The American journal of pathology 2012;181(6):2202-16.
2012: Pirjo Nummela; Olli Saksela; Johanna Soikkeli; Pirjo Laakkonen; Johanna Lammi; Erkki Hölttä
Transforming growth factor beta-induced (TGFBI) is an anti-adhesive protein regulating the invasive growth of melanoma cells.
The American journal of pathology 2012;180(4):1663-74.
2011: Pilvi Maliniemi; Kirsi Niiranen; Kristian Ovaska; Emilia Carlsson; Sampsa Hautaniemi; Leila Jeskanen; Anna Kaukola; Olli Saksela; Annamari Ranki
NAV3 copy number changes and target genes in basal and squamous cell cancers.
Experimental dermatology 2011;20(11):926-31.
2010: Johanna Soikkeli; Piotr Podlasz; Miao Yin; Pirjo Nummela; Tiina Jahkola; Susanna Virolainen; Leena Anneli Krogerus; Päivi Heikkilä; Karl von Smitten; Olli Saksela; Erkki Hölttä
Metastatic outgrowth encompasses COL-I, FN1, and POSTN up-regulation and assembly to fibrillar networks regulating cell adhesion, migration, and growth.
The American journal of pathology 2010;177(1):387-403.
2007: Pia Vahteristo; Antti Kokko; Olli Saksela; Kristiina Aittomäki; Lauri A Aaltonen
Blood-derived gene-expression profiling in unravelling susceptibility to recessive disease.
Journal of medical genetics 2007;44(11):718-20.
2007: J Soikkeli; M Lukk; Pirjo Nummela; Susanna Virolainen; Tiina Jahkola; R Katainen; L Harju; Esko Ukkonen; Olli Saksela; Erkki Hölttä
Systematic search for the best gene expression markers for melanoma micrometastasis detection.
The Journal of pathology 2007;213(2):180-9.
2006: Essi Kääriäinen; Pirjo Nummela; J Soikkeli; M Yin; M Lukk; Tiina Jahkola; Susanna Virolainen; Ari Ora; Esko Ukkonen; Olli Saksela; Erkki Hölttä
Switch to an invasive growth phase in melanoma is associated with tenascin-C, fibronectin, and procollagen-I forming specific channel structures for invasion.
The Journal of pathology 2006;210(2):181-91.
2005: Tiina Kuivanen; Katja Ahokas; Susanna Virolainen; Tiina Jahkola; Erkki Hölttä; Olli Saksela; Ulpu Saarialho-Kere
MMP-21 is upregulated at early stages of melanoma progression but disappears with more aggressive phenotype.
Virchows Archiv : an international journal of pathology 2005;447(6):954-60.
2005: Maria von Willebrand; Klaus Köhler; Tuomo Alanko; Marikki Laiho; Olli Saksela
FGF-2 blocks TGF-beta1-mediated suppression of Bcl-2 in normal melanocytes.
Experimental dermatology 2005;14(3):202-8.
2002: Tiina Jahkola; Susanna Virolainen; Esa Leppänen; Sinikka Suominen; Micaela Hernberg; Marjo Hahka-Kemppinen; Olli Saksela
[Sentinel lymph node biopsy in patients with cutaneous melanoma].
Duodecim; lääketieteellinen aikakauskirja 2002;118(22):2289-94.
2000: Tuomo Alanko; Olli Saksela
Transforming growth factor beta1 induces apoptosis in normal melanocytes but not in nevus cells grown in type I collagen gel.
The Journal of investigative dermatology 2000;115(2):286-91.
1999: Tuomo Alanko; M Rosenberg; Olli Saksela
FGF expression allows nevus cells to survive in three-dimensional collagen gel under conditions that induce apoptosis in normal human melanocytes.
The Journal of investigative dermatology 1999;113(1):111-6.
1998: Arun C Bhowmik; Hannu Paimela; T Joutsi; Tuomo Alanko; Timo Paavonen; Olli Saksela; Eero Kivilaakso
Induction of proliferation in isolated guinea pig gastric epithelium during restitution after superficial injury.
Digestive diseases and sciences 1998;43(7):1507-12.
1998: V Joukov; V Kumar; Timo Sorsa; Elena Arighi; HA Weich; Olli Saksela; Kari Alitalo
A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities.
The Journal of biological chemistry 1998;273(12):6599-602.
1997: Merja I Auvinen; A Laine; A Paasinen-Sohns; Aapo T Kangas; Lauri Kangas; Olli Saksela; Leif C Andersson; Erkki Hölttä
Human ornithine decarboxylase-overproducing NIH3T3 cells induce rapidly growing, highly vascularized tumors in nude mice.
Cancer research 1997;57(14):3016-25.
1997: V Joukov; Timo Sorsa; V Kumar; Michael Jeltsch; L Claesson-Welsh; Y Cao; Olli Saksela; Nisse Kalkkinen; Kari Alitalo
Proteolytic processing regulates receptor specificity and activity of VEGF-C.
The EMBO journal 1997;16(13):3898-911.
1996: Tuomo Alanko; J Tienari; Eero Lehtonen; Olli Saksela
FGF-2 inhibits apoptosis in human teratocarcinoma cells during differentiation on collagen substratum.
Experimental cell research 1996;228(2):306-12.
1996: V Joukov; K Pajusola; A Kaipainen; D Chilov; I Lahtinen; E Kukk; Olli Saksela; N Kalkkinen; Kari Alitalo
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.
The EMBO journal 1996;15(7):1751.
1996: V Joukov; K Pajusola; A Kaipainen; D Chilov; I Lahtinen; E Kukk; Olli Saksela; N Kalkkinen; Kari Alitalo
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.
The EMBO journal 1996;15(2):290-98.
1995: J Tienari; Tuomo Alanko; Olli Saksela; M Vesterinen; Eero Lehtonen
Fibroblast growth factor-mediated stimulation of differentiating teratocarcinoma cells: evidence for paracrine growth regulation.
Differentiation; research in biological diversity 1995;59(3):193-9.
1995: S Murtomäki; E Trenkner; Jerry Wright; Olli Saksela; Päivi Liesi
Increased proteolytic activity of the granule neurons may contribute to neuronal death in the weaver mouse cerebellum.
Developmental biology 1995;168(2):635-48.
1994: L Pertovaara; A Kaipainen; Tuija Mustonen; Arto Orpana; N Ferrara; Olli Saksela; Kari Alitalo
Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.
The Journal of biological chemistry 1994;269(9):6271-4.
1994: J Tienari; L Pertovaara; Olli Saksela; Eero Lehtonen; T Vartio
Increased expression of the matrix metalloproteinase 2 in differentiating Tera 2 human embryonal carcinoma cells.
International journal of cancer. Journal international du cancer 1994;56(2):219-23.
1994: Tuomo Alanko; J Tienari; Eero Lehtonen; Olli Saksela
Development of FGF-dependency in human embryonic carcinoma cells after retinoic acid-induced differentiation.
Developmental biology 1994;161(1):141-53.
1993: L Pertovaara; J Tienari; S Vainikka; J Partanen; Olli Saksela; Eero Lehtonen; Kari Alitalo
Modulation of fibroblast growth factor receptor expression and signalling during retinoic acid-induced differentiation of Tera-2 teratocarcinoma cells.
Biochemical and biophysical research communications 1993;191(1):149-56.
1993: L Pertovaara; Olli Saksela; Kari Alitalo
Enhanced bFGF gene expression in response to transforming growth factor-beta stimulation of AKR-2B cells.
Growth factors (Chur, Switzerland) 1993;9(1):81-6.
1992: P Kuusela; Måns Ullberg; Olli Saksela; Göran Kronvall
Tissue-type plasminogen activator-mediated activation of plasminogen on the surface of group A, C, and G streptococci.
Infection and immunity 1992;60(1):196-201.
1992: P Kuusela; Måns Ullberg; Göran Kronvall; Timo M T Tervo; Ahti Tarkkanen; Olli Saksela
Surface-associated activation of plasminogen on gram-positive bacteria. Effect of plasmin on the adherence of Staphylococcus aureus.
Acta ophthalmologica. Supplement 1992;(202):42-6.
1991: J Tienari; Tuomo Alanko; Eero Lehtonen; Olli Saksela
The expression and localization of urokinase-type plasminogen activator and its type 1 inhibitor are regulated by retinoic acid and fibroblast growth factor in human teratocarcinoma cells.
Cell regulation 1991;2(4):285-97.
1991: Erkki Koivunen; Olli Saksela; O Itkonen; S Osman; M L Huhtala; Ulf-Hakan Stenman
Human colon carcinoma, fibrosarcoma and leukemia cell lines produce tumor-associated trypsinogen.
International journal of cancer. Journal international du cancer 1991;47(4):592-6.
1990: P Kuusela; Olli Saksela
Binding and activation of plasminogen at the surface of Staphylococcus aureus. Increase in affinity after conversion to the Lys form of the ligand.
European journal of biochemistry / FEBS 1990;193(3):759-65.
1990: Olli Saksela; Marikki Laiho
[Growth factors and the extracellular matrix].
Duodecim; lääketieteellinen aikakauskirja 1990;106(3):297-306.
1987: Marikki Laiho; Olli Saksela; Jorma Keski-Oja
Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase.
The Journal of biological chemistry 1987;262(36):17467-74.
1987: L R Lund; A Riccio; P A Andreasen; L S Nielsen; P Kristensen; Marikki Laiho; Olli Saksela; F Blasi; K Danø
Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts.
The EMBO journal 1987;6(5):1281-6.
1986: Marikki Laiho; Olli Saksela; P A Andreasen; Jorma Keski-Oja
Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.
The Journal of cell biology 1986;103(6 Pt 1):2403-10.
1986: Marikki Laiho; Olli Saksela; Jorma Keski-Oja
Transforming growth factor beta alters plasminogen activator activity in human skin fibroblasts.
Experimental cell research 1986;164(2):399-407.
1985: Olli Saksela; Marikki Laiho; Jorma Keski-Oja
Regulation of plasminogen activator activity in human fibroblastic cells by fibrosarcoma cell-derived factors.
Cancer research 1985;45(5):2314-9.